INDRA Results

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databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
IL1B affects IL1R1
5 1 34 | 32 5
IL1B binds IL1R1.
1 17 | 32 5
IL1B binds IL1R1. 51 / 51
1 17 | 28 5
sparser
"Because mice deficient in the IL-1R cannot respond to IL-1, this result demonstrated that either IL-1a or IL-1b, both of which bind to the IL-1R, contributed to acute pathology after rVSV immunization."
23056330
sparser
"IL-1B and IL-1A are encoded by distinct genes and bind both to IL-1R1, found on nearly every cell and IL-1R2 ( xref )."
29760166
sparser
"Interleukin-1α (IL1α) and interleukin-1β (IL1β) both bind to IL-1R1 to initiate cell signaling."
31170999
sparser
"IL1R2 (2q11): Interleukin 1 receptor, type II binds IL1a, IL1b and IL1R1, inhibiting the activity of these ligands."
21297633
sparser
"The binding of IL-1alpha or IL-1beta to IL1R is an early step in IL-1 signal transduction and blocking this interaction may therefore be a useful target for the development of new drugs."
9062193
sparser
"Herein, we describe in vitro and in vivo nonclinical Investigational New Drug (IND)-enabling studies of EBI-005, a novel protein chimera of IL-1β and IL-1 receptor antagonist (IL-1Ra or anakinra) that potently binds IL-1R1 and blocks signaling."
28727604
sparser
"Of the three forms of IL-1, soluble type II IL-1R binds IL-1 beta with highest affinity and also selectively inhibits IL-1 beta activity."
7989776
sparser
"IL-1RI binds IL-1α, IL-1β and IL-1R antagonist (IL-1Ra)."
23994464
sparser
"These residues are poorly conserved in the deduced sequences encoding halibut and other teleost IL-1β [ xref – xref ], indicating the involvement of other amino acids in the interaction between fish IL-1β and IL-1Rs."
21643951
sparser
"IL-1R1, which binds to both IL-1α and IL-1β, can be detected in a variety of cell types, whereas the IL-1R2 is found on the cell surface of type B lymphocytes, neutrophils and macrophage, and binds with IL-1β with higher affinity[ xref ]."
24006091
sparser
"In contrast, IL-1Ra acts as an antagonist of IL-1R1, preventing the binding of IL-1α and IL-1β with IL-1R1, respectively."
27294501
sparser
"Binding of IL-1R1 with IL-1α or IL-1β leads to subsequent recruitment of IL-1RAcP at the cell membrane [ xref ] and downstream cytosolic NF-κB activation."
25706624
sparser
"IL-1ra is a cytokine produced by monocytes, macrophages, and dendritic cells, which prevents the binding of IL-1α as well as IL-1β to IL-1R1 by competitively blocking IL-1RI receptors [ xref , xref ]."
32384874
sparser
"Both IL-1α and IL-1β bind to IL-1R1 and form an activating complex with the signaling chain IL-1R3."
28642703
sparser
"Both IL-1α and IL-1β bind to same IL-1R, and bone marrow-derived macrophages produced both IL-1α and IL-1β in response to LCWE in vitro ( xref )."
26941015
sparser
"Although both IL-1α and IL-1β can interact with IL-1R1 to induce downstream transcription of inflammatory genes, they show considerable differences in their localization, regulation, and function."
28706254
sparser
"Following binding of IL-1α or IL-1β to the type I IL-1R, a second protein, the IL-1 receptor accessory protein (AcP), is recruited to the complex (Greenfeder et al., 1995) ."
12530978
sparser
"Because mice deficient in the IL-1R cannot respond to IL-1, this result demonstrated that either IL-1α or IL-1β, both of which bind to the IL-1R, contributed to acute pathology after rVSV immunization."
23056330
sparser
"IL-1α and IL-1β bind to IL-1R1 complexed to the IL-1 receptor accessory protein and induce similar physiological effects."
25764208
sparser
"Once extracellular, IL-1α and mature IL-1β bind to the IL-1R1 to initiate downstream signalling in a range of cell types [ xref ]."
27001429
sparser
"Saturation binding analysis indicates an equilibrium dissociation constant (KD) of 350 pM for the binding of IL-1R-IgG to its ligand, IL-1 beta."
7997246
sparser
"However, unexpectedly, the IL-1β-induced interaction between IL-1R and IL-1RAcP was unaffected in cells pretreated with brazilin ( Fig. 6 A, top left panel, fourth to sixth rows), indicating that down-regulation of IL-1β responsiveness by brazilin is independent of the heterodimerization between IL-1R and IL-1AcP."
24735611
sparser
"A model for the interaction of the extracellular parts of type I IL-1R and IL-1RAcP with IL-1β was proposed [68] ."
12421671
omnipath
No evidence text available
20959797
omnipath
No evidence text available
24332029
sparser
"Downstream of IL-1β activation, pharmacological inhibition of IL-1R with anakinra resulted in decreased TAA formation similar to IL-1β and IL-1R knockout mice."
25200056
biogrid
No evidence text available
7878046
sparser
"A model of IL-1RAcP was calculated on the basis of alignment of primary sequence and secondary structure with IL-1R, and then modeled on the crystal structure of IL-1R bound to IL-1β ."
11418113
sparser
"Binding of IL-1β to the IL-1R1 induces formation of a signaling complex with the IL-1 receptor accessory protein, which are both members of the Toll-like receptor family of proteins [ xref , xref ]."
22546005
reach
"Previous studies reported that IL1beta and TNFalpha exert toxic effects by binding to their cognate receptors, IL1-R1 and TNFR1, respectively, triggering downstream signaling pathways that activate transcription factors, such as NFkappaB or AP1 which in turn lead to the production of NO and ROS."
19526281
reach
"In addition, IL-1beta interaction with IL-1R1 on ECs induces migration of the cells and tube formation, mainly via activation of p38-mitogen-activated protein kinase (MAPK) and MAPK activated protein kinase 2."
24734023
sparser
"Microglia-derived IL-1β also binds to IL-1R1 on the abluminal endothelial surface, causing BMEC to release signals that further increase microglial IL-1β production and also trigger IL-6 and prostaglandin synthesis."
28668091
sparser
"The ability of Vhp19 to interfere with IL-1β binding to IL-1R was assessed and compared to inhibition of IL-1β biological activity."
11418113
reach
"The affinity of IL-1R2 for IL-1beta is 10 -10 M, while its affinity for IL-1alpha is 100 times less at 10 -8 M. IL-1R1 binds IL-1alpha at 10 -10 M, but binds IL-1beta at 10 -9 M."
23195532
reach
"The major IL-1 family members are IL-1 alpha (IL-1alpha) and IL-1 beta (IL-1beta), both of which bind to the cell surface IL-1 Receptor 1 (IL-1R1) 16."
30324661
reach
"When IL-1beta binds to IL-1R, the RhoGDI becomes phosphorylated by mechanisms that are not entirely clear and releases Rac1-GDP."
24555469
omnipath
No evidence text available
62193
omnipath
No evidence text available
9062193
omnipath
No evidence text available
9820540
omnipath
No evidence text available
9062193
omnipath
No evidence text available
8142597
omnipath
No evidence text available
62193
omnipath
No evidence text available
9062193
omnipath
No evidence text available
9820540
omnipath
No evidence text available
7878046
omnipath
No evidence text available
9062193
omnipath
No evidence text available
9062193
omnipath
No evidence text available
17145710
omnipath
No evidence text available
9062193
omnipath
No evidence text available
23331499
omnipath
No evidence text available
9062193
IL1B binds IL1R1 and IL1RN. 3 / 3
| 3
sparser
"The type I IL-1R binds IL-1α, IL-1β and the receptor antagonist IL-1Ra (reviewed in Ref. [65] )."
12421671
sparser
"In addition, IL-1R1 can be released into the extracellular space where, in its soluble form (sIL-1R1), it can also function as a soluble decoy receptor and prevent the binding of IL-1α, IL-1β, and IL-1Ra to membrane IL-1R1 ( xref )."
28588486
sparser
"On the mRNA level of MSC, we found IL1RN, which binds to IL1R on the cell surface with subsequent inhibition of the IL1beta signaling pathway, to be upregulated from a low basal level of expression upon stimulation with the PTC (318-fold) or IL1beta (107-fold) and to remain unchanged after stimulation with IL6, IL8, C3a and C5a in concentrations used in the “cocktail” ( xref )."
25562599
TLR4 binds IL1B and IL1R1. 1 / 1
| 1
sparser
"IL-1β or LPS binding to IL-1R or TLR4, respectively, results in the rapid association of the adaptor molecule Myd88 with the receptors and subsequent recruitment of the kinases IRAK1 and IRAK4. xref Activation and phosphorylation of IRAK kinases leads to the recruitment of the E3 ubiquitin ligase TRAF6 which undergoes K63-linked autoubiquitination and serves as a scaffold to recruit TAK1 and IKK kinases through binding to TAB2/3 and NEMO, respectively. xref TAK1 is subsequently activated and triggers IKK/NF-κB and mitogen-activated protein kinase/c-Jun N-terminal kinase activation. xref "
22343828
IL1B activates IL1R1.
5 17 |
IL1B activates IL1R1. 15 / 15
15 |
omnipath
No evidence text available
62193
omnipath
No evidence text available
9062193
omnipath
No evidence text available
9820540
omnipath
No evidence text available
9062193
omnipath
No evidence text available
8142597
omnipath
No evidence text available
62193
omnipath
No evidence text available
9062193
omnipath
No evidence text available
9820540
omnipath
No evidence text available
7878046
omnipath
No evidence text available
9062193
omnipath
No evidence text available
9062193
omnipath
No evidence text available
17145710
omnipath
No evidence text available
9062193
omnipath
No evidence text available
23331499
omnipath
No evidence text available
9062193
IL1B activates IL1R1. 5 / 5
5 |
bel
"The IL-1 family of receptors is comprised of ten distinct but related gene products. The receptors are indicated by the term IL-1 receptor (IL-1R) followed by a numeral, assigned chronologically by discovery, for example, IL-1R1, IL-1R2, IL-1R3, etc. The ligand binding chain for IL-1α and IL-1β is IL-1R1 and the accessory chain is IL-1R3."
bel
"After IL-1 binds to IL-1RI, an IL-1RAcP is recruited to form a high affinity IL-1R1-IL-1RAcP heterodimeric receptor, which initiates the downstream signaling cascade."
21776333
bel
"After IL-1 binds to IL-1RI, an IL-1RAcP is recruited to form a high affinity IL-1R1-IL-1RAcP heterodimeric receptor, which initiates the downstream signaling cascade."
21776333
bel
"Furthermore, IL-18R at least partly shares the signal transducing system with IL-1R. Thus, the IL-18-IL-18R system has a striking similarity to the IL-1-IL-1R system. From entrez gene summary of IL1R1: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses."
10653850
bel
"Furthermore, IL-18R at least partly shares the signal transducing system with IL-1R. Thus, the IL-18-IL-18R system has a striking similarity to the IL-1-IL-1R system. From entrez gene summary of IL1R1: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses."
10653850
IL1B activates IL1R1 bound to IL1RAP. 2 / 2
2 |
omnipath
No evidence text available
20959797
omnipath
No evidence text available
24332029
THBS1 affects CD47
16 | 40 8
THBS1 binds CD47.
8 | 40 8
THBS1 binds CD47. 54 / 54
8 | 39 7
sparser
"Binding of CD47 to other ligands such as integrins, TSP-1 and TSP-1-derived peptides, also involves the IgV domain of CD47 [ xref ]."
32421049
sparser
"In addition, TSP-1 can also bind to different integrins, CD47 and heparan sulfated proteoglycans [ xref ]."
25258675
sparser
"TSP-1 and its potential membrane receptors, e.g. alphaIIbbeta3 integrin, CD36 and CD47, concomitantly associated with the actin cytoskeleton."
11964147
sparser
"These results unveil an autocrine mechanism of calreticulin-thrombospondin-1-CD47 interaction for the control of T cell motility and migration within three-dimensional extracellular matrix substrata."
15634883
reach
"Previous work XREF_BIBR has shown that TNF-alpha up-regulates the TSP1, CD36, and CD47 complex in cultured myoblasts and that the TSP1-CD36-CD47 was up-regulated in sIBM."
21855683
sparser
"The increase in capillarity may be associated by changes in the interaction between VEGF-A, TSP-1, and CD47."
23252598
sparser
"Additional studies are required to investigate the signaling mechanism of (−)-epicatechin on the VEGF-A-TSP-1-CD47 interaction as well as determine the prolonged effects upon cessation."
23252598
sparser
"To date we have validated TSP1 antibodies that block TSP1 binding to CD47, CD47 antibodies that block TSP1 binding, and antisense approaches that suppress CD47 expression [ xref , xref – xref ]."
22685691
sparser
"Finally, results show that TSP-1 utilizes cell surface receptors CD36 and CD47 to augment chemotaxis, but DBP does not bind to TSP-1, CD36 or CD47."
22014686
sparser
"Furthermore, this paper also reveals that DBP does not bind to TSP-1, CD36 or CD47 ( xref ) and that TSP-1 utilizes these cell surface receptors to augment chemotaxis to C5a ( xref – xref )."
22014686
sparser
"TSP-1 binds CD47 to inhibit the release of interleukin (IL)-2 ."
23664438
sparser
"Ligation of CD47 by extracellular thrombospondin-1 is associated with down-regulation of IL-12 production by antigen-presenting cells [ xref ], and inhibits human naive T cell differentiation to Th1 cells but not to Th2 cells [ xref ]."
26095930
sparser
"The COOH-terminal domain of TSP-1 binds to CD47, also known as integrin-associated protein [ xref ]."
22811904
sparser
"The COOH-terminal domain of TSP-1 binds to CD47, also known as integrin-associated protein. [ xref ] This domain also interacts with integrins such as β 1 and β v6 integrins and actively binds to proteoglycans allowing cell adhesion and spreading [ xref ]."
21765615
sparser
"Because CD47 is known to associate laterally with other signaling receptors, including VEGFR2, and TSP1 binding to CD47 inhibits VEGFR2 signaling by dissociating CD47 xref , we hypothesized that interaction of CD47 with the CD14 complex might similarly modulate signal one."
26813769
sparser
"TSP-1 and SIRP-α bind CD47 IgV loop xref and TSP-1 can inhibit SIRP-α-Fc binding to CD47 expressing-Jurkat cells xref ."
22870271
sparser
"The binding of CD47 to either SIRPα or TSP1 provides two anticancer strategies."
25734483
sparser
"Given recent insights into the physiological functions of CD47, potential side effects of therapeutic CD47-antibodies such as B6H12, which inhibits both CD47-SIRP and CD47-TSP1 interactions, include altered blood pressure [ xref ], hemolytic anemia, and prothrombotic or antithrombotic activities [ xref , xref ]."
23101472
sparser
"Interestingly, both TSP-1 and SIRPα are interacting with CD47 during synaptogenesis xref , xref , xref , xref , which means that other mechanisms appear to be involved in CD47-dependent regulation of the type of nerve fiber growth investigated in the present study."
23049778
sparser
"Notably, the widely used CD47 blocking antibody B6H12 inhibits binding of both SIRPα and TSP1 to cell surface CD47 ( xref )."
25708195
sparser
"However, CD47 modified nanoparticles showed a prominent anti-phagocytosis property in M1 cells that may in part be due to the complex signalling interactions of CD47 with SIRPα and TSP-1."
27197045
sparser
"One approach to avoid these shortcomings is to identify and develop small molecule molecular probes and pretherapeutic agents that would (1) selectively target SIRPα or TSP1 interactions with CD47, (2) provide a route to optimize pharmacokinetics, reduce on-target toxicity and maximize tissue penetration, and (3) allow more flexible routes of administration."
31276567
sparser
"This data is consistent with competitive binding of TSP1 and SIRPα to a single site on CD47, steric inhibition of binding to distinct but proximal sites, or allosteric inhibition ( xref )."
25708195
sparser
"Thus, we propose that treatment of tumor-bearing animals with CD47 blocking antibodies, which are known to inhibit both SIRPα and TSP1 binding to CD47, could directly modulate adaptive as well as innate anti-tumor immunity."
25297630
sparser
"Indeed, CD47 antibody targeting may affect NO pathway modulation and subsequent angiogenesis regulation, since a commonly used CD47-blocking antibody (clone B6H12) was previously shown to concomitantly disrupt both TSP-1:CD47 and CD47:SIRPα interactions ( xref )."
26578962
sparser
"TSP1 can also interact with integrin-bound fibrinogen, which may further increase clustering between IAP and αIIb/β3."
11007943
sparser
"These activities are mediated, at least in part, by interactions of TSP1 with CD47 and HSPGs on T cells (this study; xref )."
11980922
sparser
"We discussed herein the interactions of TSP-1 with well-known partners such as CD36, CD47, NO, and TGF β 1."
21765615
sparser
"Conversely, the Ca1 domain does not interact with the TSP-1 receptors CD36 and CD47, excluding their involvement in the potentiation of PDGF."
26992552
sparser
"The C-terminal domain of TSP1 binds the cell surface receptors CD36 (glycoprotein IV) and CD47 (Integrin Associated Protein, IAP, or Rh-related antigen), and both receptors have anti-angiogenic effects."
23799952
sparser
"Nevertheless, some putative side-effects of using TAX2 as an anti-cancer agent still need to be explored, particularly as TSP-1 interaction with CD47 and/or CD36 is also known to modulate platelet aggregation ( xref )."
26578962
sparser
"In endothelial cells, TSP-1 can bind to CD36 and CD47 through its type-1 repeats and carboxyl-terminal domain to inhibit cell proliferation and promote anti-angiogenic events xref , xref ."
26273699
sparser
"Through its original mechanism of action which supposes concomitant disruption of TSP-1:CD47 interaction and enhancement of CD36 activation by TSP-1, TAX2 may inhibit tumor progression while limiting many of the undesired side effects of broadly inhibiting important physiological functions of CD47."
26578962
sparser
"Inhibition of TSP-1 binding to either CD36 or CD47 using peptide mimics of the binding sites was investigated next."
22014686
sparser
"This might be of utmost importance for the contributions of endothelial cell-mediated angiogenesis following TSP-1 binding to CD36 and CD47."
23350987
sparser
"We studied two peptides interacting with CD36, CSVTCG and GDGV(dI)TRIR [11,16] and 4N1-1, one of the two CD47 binding sites of TSP-1 [15] ."
15927849
sparser
"These results indicate that that TSP-1 cell surface binding to CD36 and CD47 is essential for chemotaxis enhancement, and suggest that CD36 may be the more important of the TSP-1 receptors for enhancing chemotaxis to C5a."
22014686
reach
"This anti-angiogenic activity results in part from the ability of physiological concentrations of TSP1 binding to CD47 to control NO signaling, which is necessary for signaling by several pro angiogenic factors [XREF_BIBR]."
22685691
sparser
"Otherwise, TSP-1 binding to CD47 also inhibits differentiation of naïve T cells into Th1 ( xref ), whereas Tregs formation is induced by promoting Foxp3 transcription factor expression ( xref ; xref )."
26578962
reach
"We have previously identified TAX2 peptide as an orthosteric antagonist for thrombospondin-1 (TSP-1) interaction with the cell-surface receptor CD47."
27842053
reach
"56 It would be interesting to investigate the effect of CD47 blockade on the antitumour capabilities of T cells, as previous studies have suggested that CD47 negatively regulates the differentiation of Th1 CD4 + T cells 195 and interacts with TSP-1 to inhibit T cell proliferation."
31462760
reach
"For example, B6H12 inhibits binding of TSP1 to human CD47, and TSP1 binding to CD47 inhibits NO signaling in vascular endothelial cells."
25708195
sparser
"Thus, we sought to identify an innovative selective antagonist for TSP-1:CD47 interaction."
26046793
sparser
"TSP1 binding to CD47 has global functional consequences by inhibiting endothelial nitric oxide (NO) production, controlling vascular tone, and maintaining systemic hemodynamics and cardiac dynamics in stressful conditions [ xref , xref , xref , xref ]."
28714932
reach
"The rule for TSP1 binding to CD47 is illustrated in Figure XREF_FIG."
28220078
reach
"The binding of CD47 to either SIRPalpha or TSP1 provides two anticancer strategies."
25734483
omnipath
No evidence text available
11980922
omnipath
No evidence text available
10397731
omnipath
No evidence text available
8550562
omnipath
No evidence text available
9169439
omnipath
No evidence text available
10397731
omnipath
No evidence text available
11980922
omnipath
No evidence text available
8550562
omnipath
No evidence text available
9169439
THBS1 binds THBS1 and CD47. 1 / 1
| 1
sparser
"Some studies demonstrate increased angiogenesis associated with TSP-1 overexpression (reviewed in [ xref ]), which could be due to the TSP1-dependent CD47 ligation, which may increase the motility and invasiveness of the tumor cells [ xref ]."
18855619
THBS1 binds CD47 and CD47. 1 / 1
| 1
reach
"In chondrocytes, a TSP, CD47, and IAP complex may associate with alpha5beta1 integrin to modulate alterations in integrin affinity and avidity state critical in the mechanotransduction process."
18186923
THBS1 activates CD47.
8 |
THBS1 activates CD47. 8 / 8
8 |
omnipath
No evidence text available
11980922
omnipath
No evidence text available
10397731
omnipath
No evidence text available
8550562
omnipath
No evidence text available
9169439
omnipath
No evidence text available
10397731
omnipath
No evidence text available
11980922
omnipath
No evidence text available
8550562
omnipath
No evidence text available
9169439
CD44 affects BSG
| 24 1
BSG binds CD44. 25 / 25
| 24 1
sparser
"Hyaluronan interacts with BCRP, extracellular matrix metalloproteinase inducer, and CD44 (the hyaluronan receptor, a stem cell marker often associated with breast cancer)."
22248732
sparser
"Following CD44 knock down, the reduction in CD44 expression was also associated with a concomitant reduction in the levels of expression of CD147, MCT4 and MRP2 ( xref )."
22870202
sparser
"Several studies have demonstrated close association of CD147 and CD44."
23178078
sparser
"CD44 and CD147 are associated with cancer metastasis and progression."
22870202
sparser
"It has also been shown that CD44 forms complexes with CD147 at the cell surface of cancer cell lines [ xref , xref ], which is indicative of the pivotal and complex role CD147 plays in KRas-driven tumors."
29899869
sparser
"oHA induce PTEN expression ( xref ), inhibit CD44 clustering on the plasma membrane, and block the interaction of CD44 with Emmprin, which is elevated in a variety of carcinomas (see Chapter 12)."
25081525
reach
"CD44 can bind EMMPRIN as well as MCT1 and MCT4 on the cell surface."
29419744
sparser
"It is reported that EMMPRIN associated with hyaluronan and CD44 enhances lactate efflux, resulting in promoting cell proliferation ( xref )."
21665938
sparser
"Perturbation of hyaluronan- CD44 interaction or down-regulation of emmprin destabilize or inhibit assembly of MCT1 and MCT4 complexes in the plasma membrane and, consequently, suppress lactate efflux."
19176383
sparser
"In contrast, internalized CD44, CD98 and CD147 were predominantly associated with endosomal tubules and vesicles that were devoid of EEA1 ( xref )."
19302270
sparser
"Meanwhile, CD147 has been reported to form a complex with integrinβ to activate PI3K/Akt pathway and then reprogram lipid metabolism through Akt/mTOR/SREBP1 signaling in HCC. xref , xref As a cancer-associated biomarker for detection and an effective target for treatment, CD147 also forms complexes with CD44 and EGFR to induces EGFR downstream signaling (ERK, pSTAT3) in breast cancer and pancreatic cancer. xref , xref Also, loss of TIP30 can improve EGFR activity in various tumors and Tip30 knockout in primary hepatocytes of mouse leads to trapping of EGF-EGFR complex, which contributes to prolonged EGFR signaling. xref , xref , xref , xref Considering both TIP30 and CD147 could regulate EGFR related signaling, it would be interesting to figure out whether downregulated TIP30 expression may synergistically act with increased CD147 expression in HCC in future research."
28604762
sparser
"In a more recent study, we demonstrated that CD147 is also associated with EGFR and CD44 in similar lipid domains and that CD147 induces invasiveness via up-regulation of EGFR-Ras-ERK and hyaluronan-CD44 signaling as well as MT1-MMP expression (Grass et al, unpublished data)."
23178078
sparser
"Additionally, we observed that CD147-mediated MT1-MMP-dependent invadopodia activity was partially dependent on CD44–hyaluronan interactions that facilitated CD44–EGFR–CD147 heterocomplex formation in lipid rafts, which resulted in Ras-ERK (extracellular signal regulated kinase) signalling."
26604323
sparser
"We also found that oncogenic Ras regulates CD147 expression, hyaluronan synthesis, and formation of CD147-CD44-EGFR complexes, thus forming a positive feedback loop that may amplify invasiveness."
23888049
sparser
"Furthermore, CD147 promotes assembly of signaling complexes containing CD147, CD44, and EGFR in lipid raftlike domains."
23888049
sparser
"As CD147 expression was significantly associated with the expression of PTTG and CD44v6, patients were divided into subgroups according to the combined expression of these EMT-associated markers to detect whether the prediction of ESSC prognosis was more accurate."
29435035
sparser
"In order to assess the association of CD147 and CD44 to MCT expression in tumours, we searched for associations among expressions of these proteins (Tables xref and xref )."
20454640
sparser
"The association of CD44 and CD147 with MCT transporter proteins has been documented for different cancers xref , xref , xref – xref ."
22870202
sparser
"Emmprin and CD44 also interact with various multidrug transporters of the ABC family and monocarboxylate transporters associated with resistance to cancer therapies."
18490190
sparser
"We find that CD44 forms complexes with MCT1, MCT4, and emmprin at the surface of human breast carcinoma cells and that these interactions most likely involve a variant form of CD44."
19176383
sparser
"In summary, we have shown here that both CD44 and emmprin interact with MCT1 and MCT4 at the plasma membrane of malignant breast carcinoma cells."
19176383
sparser
"CD147 and CD44 have been associated to MCT1 and MCT4 in different tumor types."
26993058
sparser
"Interaction of CD44 with emmprin, MCT1, and MCT4."
19176383
sparser
"CD44 can bind EMMPRIN as well as MCT1 and MCT4 on the cell surface."
29419744
sparser
"Similarly Hao et al . [ xref ] showed that CD44 and CD147 are also associated with metastatic PCa that has the potential to alter the tumor microenvironment."
23708103
ADAM15 affects ITGB3
1 6 | 15
ADAM15 binds ITGB3.
1 3 | 15
ADAM15 binds ITGB3. 17 / 17
3 | 14
sparser
"For instance, KTS disintegrins bind to αlβ1 integrins, while RGD disintegrins bind to αIIbβ3, αvβ3, and αvβ5."
22192732
sparser
"Aggrastat® (tirofiban) is based on the distance separating the side chains of Arg and Asp in the RGD motif of echistatin, a disintegrin from Echis carinatus , wich binds to αIIbβ3 and αvβ3."
26031306
sparser
"One such motif is the Arg-Gly-Asp (RGD) sequence in the C-terminal eleventh Ca 2+ -binding loop that binds the integrins αIIbβ3 and αvβ3 [6–8] ."
9858782
sparser
"In a similar manner, hantavirus also induced platelet activation and clearance by binding to platelet surface integrins αvβ3 and αIIbβ3 (Gavrilovskaya et al. 2010)."
| PMC
omnipath
No evidence text available
9516430
omnipath
No evidence text available
9914169
omnipath
No evidence text available
9516430
sparser
"The major structural changes are highlighted when the WT and mutant forms of both αIIbβ3 and αvβ3 are superimposed ( xref )."
24236036
sparser
"Although interactions between Adam12 and its integrin substrates were negatively correlated with tumor growth rate, interactions involving Adam15 and Integrin beta 3 ( Itgb3 ) were positively correlated with tumor growth rate."
30404002
sparser
"However, a significant difference was observed when binding to both platelet-derived αIIbβ3 and αvβ3 was analysed (b)."
27283740
sparser
"As shown in Fig. 2 A, 7E3 was shown to be capable of binding to platelet αIIbβ3 and endothelial αvβ3."
18312855
sparser
"MMRN1 is known to bind αvβ3, αIIbβ3 and other unidentified receptors on the platelet membrane [ xref ]."
24219705
sparser
"In fact, one antigen 5 family member (e.g., tablysin-15) has been recently described as a platelet and angiogenesis inhibitor through interaction with αIIbβ3 and αvβ3 [ xref ], and to bind leukotrienes [ xref ]."
22778902
sparser
"A 50-kDa protein physically associated with αIIbβ3 and αvβ3 was isolated some years ago [39] ."
11007943
sparser
"The narrow integrin-binding specificity of FNfn10-3JCLI4 can be contrasted with the more broad integrin-binding profile that is exhibited by disintegrins such as eristostatin and kistrin, which bind to both αIIbβ3 and αvβ3."
12595259
sparser
"Integrin β3 forms only two α-β heterodimers, αvβ3 and αIIbβ3, both of which are receptors for vitronectin [ xref ]."
26384307
sparser
"Most of them have the RGD sequence, such as accutin from Agkistrodon acutus and triflavin from Trimeresurus flavoviridis that binds to αvβ3 and αIIβ3 or rhodostomin (also known as kistrin) from Calloselasma rhodostoma ; this last one binds to αvβ3, αIIbβ3, and αvβ5."
26031306
CD47 binds ADAM15 and ITGB3. 1 / 1
| 1
sparser
"Further studies demonstrated that there was a relatively stable interaction between CD47 and αIIbβ3 or αvβ3 on platelets 7 , αvβ3 on melanoma cells 8 and ovarian carcinoma cells 9,10 , and α2β1 on smooth muscle cells 11 and platelets 12 ."
11306274
ADAM15 binds ITGAV and ITGB3. 1 / 1
1 |
hprd
No evidence text available
11882657
ADAM15 activates ITGB3.
3 |
ADAM15 activates ITGB3. 3 / 3
3 |
omnipath
No evidence text available
9516430
omnipath
No evidence text available
9914169
omnipath
No evidence text available
9516430
THBS1 affects LRP1
1 4 | 7 9
THBS1 binds LRP1. 21 / 21
1 4 | 7 9
sparser
"If cell surface LRP1 is protected by an MMP/ADAM inhibitor, and TSP-1 transport to the cell surface simultaneously is stimulated by cell contact with β1 and β2 integrin ligands, TSP-1 associates heavily with LRP1 ( xref )."
29774033
sparser
"For example, a pro-migratory signal is generated when LRP1 binds and internalizes the complex of cell surface calreticulin and thrombospondin-1 in coronary artery endothelial cells ( xref , xref )."
19549899
sparser
"The N-terminal domain of TSP1 binds to the calreticulin-LRP1 receptor co-complex to signal down-regulation of cell adhesion and increased cell motility through focal adhesion disassembly."
18653767
sparser
"Moreover, the CRT mutations could also affect CRT binding to LRP1, thereby, disrupting the formation of the TSP1-CRT-LRP1 ternary complex for signaling the cellular activities ( xref )."
21142150
reach
"Formation of the ANXA6, LRP1, and TSP1 complex was restricted to cancer associated fibroblasts (CAFs) and required physiopathologic culture conditions that improved tumor cell survival and migration."
27701147
reach
"Increased PDA aggressiveness was dependent on tumor cell mediated uptake of CAF derived ANXA6+ EVs carrying the ANXA6, LRP1, and TSP1 complex."
27701147
sparser
"In addition, the TSP1 domain of CCN2 binds to LRP1, which acts as a co-repressor of the Frizzled receptor and downregulates Wnt signaling [ xref , xref ]."
26395334
reach
"This is because TSP1, even when bound to VEGF, can bind to LRP1, increasing the number of anti-angiogenic receptor complexes, despite having a limited effect on the percentage of free or receptor bound VEGF."
28713587
reach
"Further, high affinity binding of TSP-1 to LRP likely results from the trimeric structure of TSP-1."
9045712
sparser
"Solid-phase binding assays confirmed that LRP bound to TSP1 and that the interaction was of high affinity (Kd = 5 nM)."
7775583
reach
"Although the NH 2 -terminal heparin binding domain of TSP binds LRP, and LRP mediates the endocytic degradation of TSP1 and 2, our analyses failed to demonstrate binding between LRP and the hep I sequence from the NH 2 -terminal heparin binding domain of TSP."
12821648
hprd
No evidence text available
9045712
reach
"This is because TSP1 binding to LRP1 leads to internalization, removing TSP1 from the tissue and influencing its availability to bind to other species."
28713587
reach
"Thus, LRP1 can bind, internalize, and degrade TSP1 through LRP1 binding to the NTD of TSP1."
18626063
reach
"For example, a pro migratory signal is generated when LRP1 binds and internalizes the complex of cell surface calreticulin and thrombospondin-1 in coronary artery endothelial cells."
19549899
reach
"These results indicate that TSP-1 binding to LRP-1 does not require prior or concomitant interaction with cell surface HSPG but suggest subsequent endocytosis requires high-affinity heparin binding."
14991768
sparser
"More importantly, the use of a system of astrocyte-neurons co-cultures indicated that astrocytes activated upon uPA/uPAR binding release thrombosponin-1 (TSP-1), and that the interaction between astrocytic TSP-1 and synaptic LRP1 promotes synaptic recovery in neurons that have suffered a hypoxic injury [ xref ]."
30417161
omnipath
No evidence text available
14991768
omnipath
No evidence text available
9045712
omnipath
No evidence text available
15
omnipath
No evidence text available
9045712
IL1RN affects IL1R1
18 | 3
IL1RN binds IL1R1.
9 | 3
IL1R1 binds IL1RN. 9 / 9
9 |
omnipath
No evidence text available
11641511
omnipath
No evidence text available
9062194
omnipath
No evidence text available
11641511
omnipath
No evidence text available
9062194
omnipath
No evidence text available
20959797
omnipath
No evidence text available
24332029
omnipath
No evidence text available
8142597
omnipath
No evidence text available
11641511
omnipath
No evidence text available
91
IL1B binds IL1R1 and IL1RN. 3 / 3
| 3
sparser
"The type I IL-1R binds IL-1α, IL-1β and the receptor antagonist IL-1Ra (reviewed in Ref. [65] )."
12421671
sparser
"In addition, IL-1R1 can be released into the extracellular space where, in its soluble form (sIL-1R1), it can also function as a soluble decoy receptor and prevent the binding of IL-1α, IL-1β, and IL-1Ra to membrane IL-1R1 ( xref )."
28588486
sparser
"On the mRNA level of MSC, we found IL1RN, which binds to IL1R on the cell surface with subsequent inhibition of the IL1beta signaling pathway, to be upregulated from a low basal level of expression upon stimulation with the PTC (318-fold) or IL1beta (107-fold) and to remain unchanged after stimulation with IL6, IL8, C3a and C5a in concentrations used in the “cocktail” ( xref )."
25562599
IL1RN inhibits IL1R1.
9 |
IL1RN inhibits IL1R1. 9 / 9
9 |
omnipath
No evidence text available
11641511
omnipath
No evidence text available
9062194
omnipath
No evidence text available
11641511
omnipath
No evidence text available
9062194
omnipath
No evidence text available
20959797
omnipath
No evidence text available
24332029
omnipath
No evidence text available
8142597
omnipath
No evidence text available
11641511
omnipath
No evidence text available
91
GRN affects TNFRSF1A
1 | 15 4
GRN binds TNFRSF1A.
| 14 4
TNFRSF1A binds GRN. 18 / 18
| 14 4
sparser
"TNFR 1 binding to PGRN’s F-A-C domain prevents the activation of the NF-KB pathway by TNFα and the resultant chondroprotective inhibition of the degradation of COMP by ADAMTS-7."
24389211
reach
"Based on the confirmation of PGRN binding to TNFR1 and TNFR2 in HeLa cells, we demonstrated that TNFR2 was needed for PGRN stimulated mTOR signaling in cervical cancer cells."
27517315
sparser
"PGRN binds to TNFR1 and activates ERK and PI3K/AKT pathways to competitively inhibit TNF-α activated NF-κB inflammatory pathway [ xref , xref , xref , xref , xref ]."
30733059
reach
"Importantly, PGRN directly binds to TNFR1 and TNFR2 in many cell types XREF_BIBR XREF_BIBR XREF_BIBR, here, we also found that TNF induced CXCL9 and CXCL10 depends on TNFR1, and PGRN 's inhibitory effect upon CXCL10 and CXCL10 is mainly mediated through TNFR1 (XREF_FIG)."
26892362
sparser
"PGRN binds to TNFR1 with binding affinity comparable to that of TNFα, and binds to TNFR2 with much higher affinity than TNFα xref ."
27527809
reach
"Furthermore, treatment of mice with TNF receptor (TNFR) -1 blocking peptide-Fc, a TNFR1 blocking peptide-Fc fusion protein to competitively block the interaction of PGRN and TNFR1, resulted in the restoration of systemic insulin sensitivity and the recovery of autophagy and insulin signaling in liver."
25664864
reach
"It was reported that PGRN can competitively bind to TNFR1 and TNFR2 and prevents TNFalpha mediated inflammation XREF_BIBR."
26853108
sparser
"This result revealed that in the interaction between PGRN and TNFR1, the CRD3 domain of TNFR1 was the determinant for the binding, whereas CRD2 played an important role in enhancing this binding to a substantial degree."
24070898
sparser
"Surface plasmon resonance analysis revealed that PGRN bound to both TNFRI and TNFRII and with greater affinity than TNF to TNFRII xref , xref ."
27428882
sparser
"The binding of PGRN with TNFR1 and TNFR2 in HeLa cells was confirmed by Co-immunoprecipitation (Co-IP) assays (Figure xref )."
27517315
sparser
"As summarized in xref , the successful demonstration of the binding of PGRN to TNFR1 and TNFR2 in surface plasmon resonance is highly dependent upon the chips used."
24070898
sparser
"However, despite the strong affinities of the PGRN–TNFR1 and PGRN–TNFR2 interactions, excessive high concentrations of PGRN (75,000 ng/ml = 833 nM) were required to see inhibitory effects on binding of sTNF to TNFR1 and TNFR2 and this although TNF receptor activities were inhibited at much lower PGRN concentrations (Table xref )."
29740434
sparser
"PGRN binds both TNFR1 (which is broadly expressed) and TNFR2 (which is primarily expressed by leukocytes) in a dose-dependent manner ( xref )."
21892758
sparser
"The unexpected interaction between progranulin (PGRN) and both TNFRI and TNFRII is particularly interesting in the context of arthritis‐associated bone pathology."
27428882
sparser
"Importantly, PGRN directly binds to TNFR1 and TNFR2 in many cell types xref xref xref , here, we also found that TNF-induced CXCL9 and CXCL10 depends on TNFR1, and PGRN’s inhibitory effect upon CXCL10 and CXCL10 is mainly mediated through TNFR1 ( xref )."
26892362
sparser
"TNF-α-mediated activation of NF-κB signalling pathway is known to play an important role in the pathogenesis of OA. xref The finding that PGRN directly binds to TNFR1 and TNFR2, and prevents TNF-mediated inflammation in various conditions xref xref xref has been independently confirmed by several laboratories. xref xref xref – xref Additionally, this finding was further confirmed and extended by the recent report that PGRN directly bound to TNFRSF25 (DR3) and inhibited TNF-like ligand 1A (TL1A) activity. xref PGRN binds to TNFR2 with higher binding affinity than to TNFR1, xref xref and TNFR2 has been demonstrated to be critical for PGRN activities."
25169730
sparser
"Recently, two other groups independently reproduced the binding of PGRN to TNFR1 and TNFR2, and inhibitory effect of this binding on TNF-α-induced effects [ xref , xref ]."
24321127
sparser
"Our results obtained in highly sensitive cellular binding studies with two commercially available PGRN samples and GpL-tagged and untagged PGRN containing cell culture SNs also gave no evidence for high affinity and/or competitive PGRN binding to TNFR1 and TNFR2."
29740434
GRN inhibits TNFRSF1A.
1 | 1
GRN inhibits TNFRSF1A. 2 / 2
1 | 1
sparser
"This hyperphosphorylation prevents direct inhibition of TNFR1, TNFR2 and DR3 by PGRN, alters the conversion of PGRN, and is strongly associated with the occurrence of neutralizing, proinflammatory PGRN-antibodies, indicating immunogenicity of this alternative secondary modification."
26005049
signor
"Collectively, these findings demonstrate that pgrn is a ligand of tnfr, an antagonist of tnf signaling, and plays a critical role in the pathogenesis of inflammatory arthritis in mice."
21393509
MMP13 affects LRP1
8 | 6 5
MMP13 binds LRP1.
4 | 6 5
LRP1 binds MMP13. 15 / 15
4 | 6 5
reach
"Furthermore, competition studies on the MMP-13 binding to LRP1 showed that the addition of neither MMP-1 nor MMP-13-13-1 inhibits the MMP-13 binding to LRP1, whereas Hpx MMP-13 and MMP-1-1-13 similarly inhibited the binding in a dose dependent manner (XREF_FIG D), supporting our conclusion described above."
27084377
reach
"We also show here that MMP-13 directly binds to LRP1 via its hemopexin (Hpx) domain (Hpx MMP-13) and its binding clusters in LRP1 have been determined."
27084377
sparser
"LRP1 was associated with the function of MMP-13 in the physiological turnover of the ECM [ xref ]."
29126436
reach
"Interestingly, MMP-13 bound LRP-1 via its haemopexin domain at a site distinct to ADAMTS-5, ADAMTS-4 and TIMP3, which permits co-endocytosis with these proteins 101."
30828429
sparser
"Both MMP-13 and Hpx MMP-13 bound to immobilized LRP1 with K D , app values of 3.8 nM and 2.7 nM, respectively ( xref C and xref ), suggesting that Hpx MMP-13 is essential for the interaction with LRP1."
27084377
sparser
"MMP-13 directly binds to LRP1 via its Hpx domain."
27084377
reach
"2.4 Effect of heparin on the binding of MMP-13 to LRP1."
27084377
sparser
"For example, low-density lipoprotein receptor-related protein 1 (LRP1) binds both pro- and activated MMP-13, and is a key modulator of the extracellular levels of MMP-13."
29126436
reach
"2.5 Binding of MMP-13 to LRP1 ligand binding clusters."
27084377
sparser
"Furthermore, competition studies on the MMP-13 binding to LRP1 showed that the addition of neither MMP-1 nor MMP-13-13-1 inhibits the MMP-13 binding to LRP1, whereas Hpx MMP-13 and MMP-1-1-13 similarly inhibited the binding in a dose-dependent manner ( xref D), supporting our conclusion described above."
27084377
omnipath
No evidence text available
10514490
omnipath
No evidence text available
10514495
omnipath
No evidence text available
10514495
omnipath
No evidence text available
10514495
sparser
"We also show here that MMP-13 directly binds to LRP1 via its hemopexin (Hpx) domain (Hpx MMP-13 ) and its binding clusters in LRP1 have been determined."
27084377
MMP13 activates LRP1.
4 |
MMP13 activates LRP1. 4 / 4
4 |
omnipath
No evidence text available
10514490
omnipath
No evidence text available
10514495
omnipath
No evidence text available
10514495
omnipath
No evidence text available
10514495
IL1B affects TLR4
3 | 10 6
IL1B binds TLR4.
| 10 6
TLR4 binds IL1B. 15 / 15
| 9 6
sparser
"Although HMGB1 has been shown to stimulate pro-inflammatory cytokine production xref , xref , xref , it is unlikely that HMGB1 interacts with TLR4 to promote IL-1β production and cell death in our system."
22563435
sparser
"Functional studies revealed that this NFKBIA rs2233406 genotype was associated with elevated TLR4-mediated IL-1β production."
28428267
sparser
"The second principal component indicates that the high expression of TLR-4 was associated with high expression of pro-inflammatory cytokines TNF-α and IL-1β ."
29118977
reach
"The gram negative bacterial cell wall component LPS and IL-1beta, which bind to Toll Like Receptor 4 (TLR4) and the IL-1 Type-I receptor (IL-1RI), respectively, play a pivotal role in this process."
21029443
sparser
"The gram-negative bacterial cell wall component LPS and IL-1β, which bind to Toll-Like Receptor 4 (TLR4) and the IL-1 Type-I receptor (IL-1RI), respectively, play a pivotal role in this process."
21029443
reach
"Our results also propose that IL-1beta may bind to TLR4, in addition to its cognate receptor IL-1R1, to exert its inflammatory effects in microglia, which is a novel finding and needs to be further explored."
26838598
sparser
"Our results also propose that IL-1β may bind to TLR4, in addition to its cognate receptor IL-1R1, to exert its inflammatory effects in microglia, which is a novel finding and needs to be further explored."
26838598
reach
"The association between precancerous gastric lesions and serum pepsinogens, serum gastrin, vascular endothelial growth factor, serum interleukin-1 Beta, serum toll like receptor-4 levels and Helicobacter pylori Cag A status."
23137754
reach
"The four SNPs that had significant single SNP associations with either IL-1alpha (IL-1RAP rs6444435) or IL-1beta (IL-1R2 - rs4851527 and rs4851531, IL-1RAP - rs6765375) in AA were tested for interaction effects with the two SNPs in TLR4 (rs1554973 and rs7856729) that were associated with IL-1alpha and IL-1beta in European Americans in a previous study."
21704385
reach
"6 Binding of IL-1beta to IL-1R or LPS to TLR4 causes recruitment of adopter proteins such as MyD88, IRAK, and TRAF6 to the receptor."
22833096
reach
"The aim of this study was to investigate the association between serum pepsinogens, serum gastrin, serum vascular endothelial growth factor, serum interleukin-1 Beta, serum toll like receptor-4 levels and Helicobacter pylori Cag A status in patients with various gastric precancerous lesions."
23137754
sparser
"The four SNPs that had significant single SNP associations with either IL-1α (IL-1RAP rs6444435) or IL-1β (IL-1R2 – rs4851527 and rs4851531, IL-1RAP – rs6765375) in AA were tested for interaction effects with the two SNPs in TLR4 (rs1554973 and rs7856729) that were associated with IL-1α and IL-1β in European Americans in a previous study ( xref [pd1] )."
21704385
sparser
"Both types of glial cells release Tnf and produce the immature form of Il1b in a Tlr4-dependent manner in the presence of Hsp70."
24755298
sparser
"Since previous reports showed that the production of IL-1β is associated with TLR2 and TLR4 pathway [ xref ], we thus speculated that the inhibitory effect of ischemic postconditioning on the IL-1β production might be correlated with inhibition of TLR2 or TLR4 pathway."
24460643
sparser
"Elevated production of IL-1β from monocytes following TLR-2, TLR-4 and TLR-7/8 stimulation was associated with reduced odds of TB recurrence."
27654812
TLR4 binds IL1B and IL1R1. 1 / 1
| 1
sparser
"IL-1β or LPS binding to IL-1R or TLR4, respectively, results in the rapid association of the adaptor molecule Myd88 with the receptors and subsequent recruitment of the kinases IRAK1 and IRAK4. xref Activation and phosphorylation of IRAK kinases leads to the recruitment of the E3 ubiquitin ligase TRAF6 which undergoes K63-linked autoubiquitination and serves as a scaffold to recruit TAK1 and IKK kinases through binding to TAB2/3 and NEMO, respectively. xref TAK1 is subsequently activated and triggers IKK/NF-κB and mitogen-activated protein kinase/c-Jun N-terminal kinase activation. xref "
22343828
IL1B increases the amount of TLR4.
3 |
Transcriptionally active IL1B increases the amount of TLR4. 3 / 3
3 |
biopax:ctd
No evidence text available
20816778
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
SORT1 affects GRN
2 | 10 5
SORT1 binds GRN. 16 / 16
2 | 9 5
sparser
"PGRN is able to bind to the beta propeller region of sortilin through its C-terminal tail."
29116422
sparser
"In this study, we extend the previous discovery by demonstrating that PGRN also interacts with TNFR in immune system cells, examine the effects of PGRN folding on its binding to receptors by comparing the binding of PGRN to TNFR and Sortilin under various conditions, and provide information for recapitulating the high-affinity binding of PGRN to TNFR."
24070898
omnipath
No evidence text available
23236149
omnipath
No evidence text available
24070898
sparser
"PGRN Binding to Neuronal Sortilin."
21092856
reach
"As we mentioned in the Introduction, in neuronal cells progranulin interacts with sortilin, which promotes progranulin internalization and targeting for lysosomal degradation [XREF_BIBR]."
25839164
sparser
"PGRN binds only to Sortilin ( xref , xref )."
21092856
reach
"Upon binding to GRN, sortilin and GRN complex is rapidly endocytosed and delivered to lysosomes thereby regulating the extracellular levels of GRN."
21863317
sparser
"The Interaction Between Progranulin with Sortilin and the Lysosome."
29956282
sparser
"Interaction between PGRN and sortilin was reported to be critical for their trafficking into lysosomes, particularly in neurons [ xref , xref ]."
30733059
sparser
"Indeed, the binding affinity between progranulin and EphA2 is similar to the reported interaction of progranulin and sortilin (∼15.4 nM; xref )."
27903606
reach
"Since the binding of PGRN to SORT1 was hindered by the C-terminal tag, we next compared the ability of His rPGRN and rPGRN-His to promote outgrowth and branching in primary hippocampal cultures."
22781549
reach
"The interaction between sortilin and PGRN is thought to be crucial to regulate PGRN trafficking in neurons [XREF_BIBR, XREF_BIBR]."
28194047
reach
"Sortilin in complex with p75NTR also performs proneurotrophin apoptotic signaling, but GRN binding to sortilin does not seem to be modulated by p75NTR."
21863317
sparser
"These results suggest that the functional interaction between sortilin, SLPI, and progranulin levels may be critical for prostate cancer, and sortilin/SLPI loss may contribute to progranulin-dependent action in prostate cancer progression (Figure xref )."
27512385
sparser
"To test this hypothesis, PGRN was pretreated with 10mM DTT, which is known to disturb the formation of disulfide bonds in PGRN and in turn affects its folding, and then the binding of PGRN to TNFR2 and Sortilin were measured using solid phase binding."
24070898
SORT1 binds GRN and NGFR. 1 / 1
| 1
sparser
"While we did not observe modulation of PGRN binding to Sortilin by p75NTR, pro-neurotrophin action may be altered in a more complex in vivo setting."
21092856
IL1B affects F3
10 | 7
IL1B increases the amount of F3.
10 |
Transcriptionally active IL1B increases the amount of F3. 10 / 10
10 |
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
IL1B binds F3.
| 7
F3 binds IL1B. 7 / 7
| 7
sparser
"Subsequent experiments revealed WIN 55,212-2 to impair the phosphorylation of p38 MAPK and JNK thereby proving an additional target of the cannabinoid in interfering with TF formation by IL-1β."
27556861
sparser
"In addition, the stimulatory effect of ceramide on basal and IL-1β-induced TF protein formation was confirmed by incubating cells with nSMase from B. cereus (Figure xref )."
27556861
sparser
"First, treatment of cells with nSMase spiroepoxide inhibitor [ xref ], which selectively inhibits the nSMase-catalyzed hydrolysis of membrane sphingomyelin to ceramide, was associated with a substantial suppression of IL-1β-induced TF formation and cellular ceramide levels."
27556861
sparser
"Whereas treatment of cells with nSMase spiroepoxide inhibitor was associated with a substantial suppression of IL-1β-induced TF formation, fumonisin B 1 and ISP-1 failed to elicit such effect (Figure xref )."
27556861
sparser
"According to Figure xref , inhibition of all kinases was associated with a partial but significant inhibition of IL-1β-induced TF formation with the most pronounced effect observed with the p38 MAPK inhibitor."
27556861
sparser
"In the presence of IL-1β, however, additional treatment with AM-630 as well as the combination of AM-251 and AM-630 was associated with a further significant increase of IL-1β-induced TF protein levels (Figure xref )."
27556861
sparser
"Whereas treatment of cells with nSMase spiroepoxide inhibitor was associated with a substantial suppression of IL-1β-induced TF formation, fumonisin B 1 and ISP-1 failed to elicit such effect (Figure xref )."
27556861
CD47 affects ADAM15
| 17
CD47 binds ADAM15. 16 / 16
| 16
sparser
"Thus, removal of cholesterol compromised association of αvβ3 with IAP and trimeric G protein."
10444074
sparser
"Recently, association of αvβ3 and IAP with trimeric G proteins has been demonstrated ( xref ), suggesting a mechanism by which the αvβ3/IAP complex may signal."
10444074
sparser
"On monocytes, the αvβ3–CD47 complex binds to soluble CD23 and signals cytokine synthesis in response to binding 33 ."
11306274
sparser
"It is possible that this rise in i[Ca 2+ ] is mediated through the binding of the α3(IV) peptide to the CD47 and αvβ3 integrin complex [3] ."
10822174
sparser
"Although CD47 has only five transmembrane domains, rather than the seven that are typical of GPCRs, it has been suggested that a complex formed by CD47 and an integrin heterodimer such as αvβ3 could function as a GPCR xref – xref ."
19643963
sparser
"CD47 associates laterally with αvβ3 and several other integrins [ xref ]."
23101472
sparser
"Nonetheless, these experiments suggest that the IAP Ig domain is an important component of the interaction of IAP with αvβ3."
10444074
sparser
"However, the molecular mechanisms involved in association of αvβ3 with IAP or of this membrane complex with G proteins have not been resolved."
10444074
sparser
"Treatment with MβCD markedly decreased association of both IAP and Gβ with the purified αvβ3 ( xref A)."
10444074
sparser
"The mechanism of the MMS effect is likely to involve its ability to bind to cholesterol because cholesterol is required for stable, immunoprecipitable association of CD47 with αvβ3 10 ."
11306274
sparser
"Expressing CD47 in CD47-deficient OV10 cells increased binding of the activation-dependent antibodies LIBS1 and LIBS6 to αvβ3 ( xref )."
25708195
sparser
"Trimeric G proteins have been identified as a signal transduction component associated with IAP and αvβ3 ( xref )."
10444074
sparser
"Although CD47 associates with αvβ3 and augments its function, β3 −/− CD47 −/− mice have rather different phenotypes."
19276363
sparser
"This has led to the hypothesis that IAP and αvβ3 form a signaling complex in at least some cells that can influence specific cell functions."
10444074
sparser
"In this model, the cholesterol-replete conformation of IAP can interact with αvβ3, and for this, the Ig domain is required."
10444074
sparser
"A previous study suggested that the interaction between IAP and αvβ3 could occur through the IAP Ig domain ( xref )."
10444074
CD47 binds ADAM15 and ITGB3. 1 / 1
| 1
sparser
"Further studies demonstrated that there was a relatively stable interaction between CD47 and αIIbβ3 or αvβ3 on platelets 7 , αvβ3 on melanoma cells 8 and ovarian carcinoma cells 9,10 , and α2β1 on smooth muscle cells 11 and platelets 12 ."
11306274
THBS1 affects SCARB2
1 | 11 4
THBS1 binds SCARB2.
1 | 4 4
THBS1 binds SCARB2. 9 / 9
1 | 4 4
sparser
"In addition, LIMP-2 can bind to TSP1 ( xref ) and TSP2 (not depicted)."
17485520
reach
"Because LIMP-2 is predominantly localized on intracellular membrane bound compartments and exhibits only low levels of cell-surface expression (Okazaki et al., 1992; Suarez-Quian, 1987), it is possible that the interaction between LIMP-2 and TSP-1 does not predominate in the physiological setting, particularly given that TSP-1 is found in the matricellular environment."
18022370
sparser
"Because LIMP-2 is predominantly localized on intracellular membrane-bound compartments and exhibits only low levels of cell-surface expression (), it is possible that the interaction between LIMP-2 and TSP-1 does not predominate in the physiological setting, particularly given that TSP-1 is found in the matricellular environment."
18022370
reach
"60 TSP1 binds to the CD36, LIMP-2, Emp sequence homology domain (AA 93-155) via its TSR, and oxLDL binds to the site (AA 155-183) next to the CD36, LIMP-2, Emp sequence homology domain."
30567481
sparser
"To test whether LIMPII also binds TSP1, a LIMPII peptide corresponding to the TSP1 binding domain of CD36 was expressed as a recombinant glutathione S-transferase (GST) fusion protein."
9478926
biogrid
No evidence text available
9478926
reach
"We recently showed that the corresponding sequence of the CD36 homolog LIMPII bound TSP1 with high affinity, confirming a functionally identical domain."
9419208
reach
"To determine the extent of TSP1 contribution to saliva inhibition of HIV infectivity, clarified saliva samples were passed over affinity columns of immobilized TSP binding LIMPII fusion protein LFP75-155 before virus preincubation."
9419208
sparser
"To demonstrate that TSP-1 peptides interacted only with CD36 fusion proteins containing the TSP-1 binding domain ( xref ), their ability to block 125 I–TSP-1 binding to immobilized CD36 and CD36–GST fusion proteins was tested (Fig. xref B )."
9245797
THBS1 activates SCARB2.
| 7
THBS1 activates SCARB2. 7 / 7
| 7
sparser
"Activation of CD36 by TSP-1 phosphorylates p38 and JNK, which results in an increased expression of FasL and apoptosis ( xref ), which we saw in our tumor cells in response to ABT-510."
19139114
sparser
"The trimeric TSP1 fragment that activates both CD148 and CD36 may be a powerful tool for anti-angiogenesis therapy."
27149518
sparser
"Through its original mechanism of action which supposes concomitant disruption of TSP-1:CD47 interaction and enhancement of CD36 activation by TSP-1, TAX2 may inhibit tumor progression while limiting many of the undesired side effects of broadly inhibiting important physiological functions of CD47."
26578962
sparser
"TSP-1 activates CD36, a transmembrane glycoprotein found on macrophages and endothelial cells [ xref , xref ]."
19481138
sparser
"Moreover, we show that activation of CD36 by TSP-1 down-modulates the VEGF receptor-2 (VEGFR-2) and p38 mitogen-associated protein kinase phosphorylation induced by VEGF-A165, and this effect was specifically abolished by point mutation at C464."
16037098
sparser
"Integrin-associated matricellular protein receptors such as CD47 and CD36 have recently been shown to be involved in pathological ROS production. xref Activation of CD47 and CD36 by thrombospondin-1 (TSP1) inhibits NO signaling xref in VSMCs and may contribute to eNOS uncoupling. xref Additionally, knockout studies of CD36 have implicated CD36 activity in the regulation of Nrf2 nuclear export and degradation, xref which ultimately results in higher levels of oxidative stress due to reduced antioxidant expression."
25634975
sparser
"Second, in higher concentrations TSP-1 binds and activates CD36, thereby decreasing intracellular cGMP-levels due to interaction with cellular uptake of myristic acid and decreased eNOS-dependent synthesis of nitric oxide [ xref ]."
27473366
CD4 affects BST2
| 12 1
BST2 binds CD4. 13 / 13
| 12 1
sparser
"This protein–protein interaction varies according to the particular viroporin analysed; for instance Viral Protein Unique (Vpu) interacts with CD4 receptor and tetherin (BST2), thereby facilitating the budding of virus particles."
26702461
sparser
"Mechanistically, tetherin blocks HIV-1 particle release and, therefore, leads to the formation of aggregated viral particles at the host cell membrane, while Vpu mediates interaction of either CD4 or BST2 to BTRC (βTrCP-1), a substrate recognition subunit of the Skp1/Cullin/F-box E3 ubiquitin ligase, leading to their ubiquitination and subsequent proteasomal degradation [ xref ]."
29258265
sparser
"Additionally, considering the importance of the structural configuration of Vpu for targeting both BST2 and its other host protein target CD4, as well as the roles of disordered regions in modulating structural orientation or affording structural plasticity that facilitates interaction with target proteins, we further examined whether these conserved hinge region residues orient Vpu in such a way that binding to BST2 and CD4 is favoured."
28288652
sparser
"Given that f-actin formation in isolated human CD4-positive lymphocytes is an important mechanism in cell polarisation during cell migration xref , xref , we next investigated the effect of GLP-1(9-36) on f-actin formation in isolated human CD4-positive lymphocytes using flow cytometry analysis."
23469279
reach
"Mechanistically, tetherin blocks HIV-1 particle release and, therefore, leads to the formation of aggregated viral particles at the host cell membrane, while Vpu mediates interaction of either CD4 or BST2 to BTRC (betaTrCP-1), a substrate recognition subunit of the Skp1/Cullin/F-box E3 ubiquitin ligase, leading to their ubiquitination and subsequent proteasomal degradation [XREF_BIBR]."
29258265
sparser
"To investigate whether our assay allows to map interacting domains within proteins, we analysed a variety of previously described Vpu mutants xref for their capacity to bind CD4 and CD317 ( xref )."
20179761
sparser
"Taken together with the BST2 binding data, the results demonstrate that the E28/L33 residues are essential for optimal binding to both BST2 and CD4."
28288652
sparser
"It remains to be elucidated whether the hinge region glutamate residue in VpuC contributes towards binding to BST2 and/or CD4, and whether it is involved as a part of an active trafficking signal."
28288652
sparser
"To further define the viruses’ affinity for CD4 we compared the binding of CD4-IgG 2 to cell surface-expressed envelope trimers by flow cytometry."
28264054
sparser
"In recent years it has become evident that Vpu from HIV-1 is interacting with a number of host factors such as CD4, BST-2 and NTB-A (reviewed in )."
24036078
sparser
"Additionally, we show direct binding of HIV-1 Vpu to CD4 and the recently described restriction factor CD317 (also termed Bst-2 or tetherin), which inhibits retroviral particle release from infected cells xref ."
20179761
sparser
"However, Vpu also binds the HIV cell surface receptor CD4 and the restriction factor tetherin, promoting their ubiquitination and degradation by bringing them in close proximity to the SCF β-TrCP E3 ligase complex ( xref , xref )."
25605733
sparser
"Beside these interesting changes, the specific determinants for CD4, BST-2 and β-TrcP binding remained highly conserved ( xref ) among all the variants xref – xref , xref – xref ."
23555649
PLAUR affects ITGAM
1 | 7 3
ITGAM binds PLAUR. 11 / 11
1 | 7 3
sparser
"The extensively glycosylated uPAR binds to the same C-terminal lectin domain of CD11b that had previously been shown to prime Mac-1/CR3 for cytotoxic degranulation in response to beta-glucan."
12018461
sparser
"If the uPAR-CD11b interaction is central to metastatic outgrowth, ATN-658 may be targeting the most clinically relevant and actionable aspect of metastasis."
24465541
sparser
"Although we cannot rule out a steric effect of ATN-658 on the uPAR interaction with a5β1, we hypothesize that ATN-658 may alter global integrin clustering and signaling through the inhibition of the CD11b-uPAR interaction."
24465541
reach
"CD11b, also known as Mac1, a leukocyte alpha M beta 2 -integrin receptor that binds fibrinogen, can interact with uPAR [6]."
18762175
sparser
"Although uPAR was associated with CD11b (CR3) on live resting cells, polarized migratory HRPE cells were found to dissociate uPAR from CR3; uPAR then translocated to anterior pole of the cell, where it enhanced PAI-1-inhibitable local proteolytic activity."
12697422
sparser
"The contribution of each of these interactions to tumor progression and the molecular mechanisms that are downstream of uPAR-CD11b binding remain to be elucidated and are a major focus for future studies."
24465541
reach
"Next, we investigated whether the lack of effect by the disubstituted phosphorylation like variant can be exclusively observed in cells of the myelomonocytic lineage, where uPAR interacts with the beta2-integrin CD11b and CD18 or Mac-1."
9151681
sparser
"In that regard, a peptide, M25, that blocked the uPAR-CD11b interaction was demonstrated to also inhibit the interaction of uPAR with β1 integrins (32)."
24465541
sparser
"ATN-658 blocks the CD11b–uPAR interaction, which leads to the hypothesis that uPAR may actually function to promote metastasis xref ."
26673349
biogrid
No evidence text available
10744708
reach
"One hypothesis is that uPAR on a tumor cell may interact with CD11b on a leukocyte in the pre-metastatic niche in trans and this interaction may mediate survival and outgrowth of the uPAR expressing tumor cells, possibly by dampening T cell or innate immune response at the metastatic site."
24465541
INPP5K affects CPD
| 11
CPD binds INPP5K. 11 / 11
| 11
sparser
"To further confirm the involvement of NER mechanism in the repair of CPDs and 6-4-PPs, we examined the effect of NPs pretreatment on UVB-induced CPDs and 6-4-PPs formation in NER-proficient and -deficient cells using dot blot analysis ( xref )."
27693632
sparser
"The enzyme binds CPD or 6-4 PPs at lesion sites and splits the dimers back to undamaged bases."
27148370
sparser
"This work left a number of questions unanswered including: (1) What types of DNA photoproducts, CPDs or 6-4 PPs, are formed at photoproduct hotspots? (2) Do the locations of mutagenic hotspots in the lacI gene correlate primarily with sites of high-frequency CPD formation or 6-4 PP formation? and (3) Does the rate of repair of CPDs and 6-4 PPs vary, and if so, what effect does this have on photoproduct hotspots becoming mutation hotspots?"
10838132
sparser
"To determine the relative frequency of formation of CPDs and 6-4 PPs in the lacI and lacZ genes, E. coli cells were UV irradiated with 0, 100, 200, or 400 J/m 2 ."
10838132
sparser
"Significant less CPDs or 6-4-PPs formation was observed in UVB-irradiated NER-proficient cells that were pretreated with Ag-NPs."
27693632
sparser
"Most photoproducts are at sites where both CPDs and 6-4 PPs are formed."
10838132
sparser
"Our previous analysis of the UV-induced DNA photoproduct distribution of the first 184 bp of the E. coli lacI gene left a number of questions unanswered, including: (1) What types of DNA photoproducts, CPDs or 6-4 PPs, are formed at photoproduct hotspots? and (2) Do the locations of mutation hotspots in the lacI gene primarily correlate with sites of high-frequency CPD formation or 6-4 PP formation? [5] ."
10838132
sparser
"Formation of CPDs and 6-4 PPs was also examined by immunostaining on the same skin specimens."
10733270
sparser
"To address these questions at the nucleotide level, a lesion-specific reiterative PE assay was utilized to determine the in vivo location and relative frequency of formation of CPDs and 6-4 PPs in the first 52 codons of the E. coli lacI gene (between nucleotides 29 and 184 on both strands) (Fig. 5A–F) ."
10838132
sparser
"Pyrimidine dimers, such as CPDs and 6-4 PPs, are formed through direct photon absorption by DNA bases ( xref ; xref )."
32141475
sparser
"In addition, a crystal structure of DDB2 bound to (6-4)PPs or CPDs have been resolved xref , xref ."
24489677
VLDLR affects THBS1
| 4 5
THBS1 binds VLDLR. 8 / 8
| 3 5
reach
"Recently, it was also shown that thrombospondin-1 binds to Apoer2 and VLDLR in the brain where it participates in the chain migration of postnatal neurons along the rostral stream."
20868222
reach
"Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration."
18946489
sparser
"And the proliferation of microvascular endothelial cells can be inhibited by the interaction of TSP-1 with very low density lipoprotein receptor (VLDLR) ( xref )."
19360900
sparser
"The proliferation of HMVECs could be inhibited by the interaction of TSP1 with the very low density lipoprotein receptor (VLDLR)."
29137447
sparser
"Using adenovirus-mediated gene transfer experiments, we demonstrate that the very low density lipoprotein receptor can also bind and internalize TSP-1."
9045712
reach
"Similarly, we identified Thrombospondin-1 (THBS1), which binds to LRP8 (a.k.a. APOER2) and VLDLR receptors, also receptors for reelin, and seems to play a role in murine postnatal neuronal migration, as well as in synaptogenesis XREF_BIBR, XREF_BIBR."
21445258
reach
"In contrast to these antiangiogenic phenomena, TSP-1 may also bind ApoER2 (apolipoprotein E receptor 2) and VLDLR to promote neuronal migration."
19360900
reach
"has confirmed the interaction between the VLDLR and TSP-1."
19798599
THBS1 binds VLDLR and LRP8. 1 / 1
| 1
sparser
"Recently, it was also shown that thrombospondin-1 binds to Apoer2 and VLDLR in the brain where it participates in the chain migration of postnatal neurons along the rostral stream ( xref )."
20868222
TLR4 affects ENO1
| 5 4
TLR4 binds ENO1. 9 / 9
| 5 4
sparser
"These well-documented data led us to evaluate the binding of ENO1 to TLR4."
27025255
reach
"Further to our present results that show ENO1 binding to TLR4, it would be interesting to study the direct interaction of ENO1 TLR4 and CD14 by surface plasmon resonance technology for better understanding of ENO1 action and to highlight the specific pathways involved."
27025255
reach
"This observation suggests that citrullination does not alter ENO1 binding to TLR4 or subsequent inflammatory response, while a loss of function has been reported for other proteins such as MBP-1 in multiple sclerosis XREF_BIBR."
27025255
sparser
"In order to compare the binding of ENO1 and LPS to TLR4, we performed a competitive binding assay with ENO1 and FITC-labelled LPS using HEK-Blue hTLR4 cells."
27025255
reach
"These well documented data led us to evaluate the binding of ENO1 to TLR4."
27025255
sparser
"These results suggest that ENO1 binds TLR4 to induce a pro-inflammatory response."
27025255
sparser
"These results suggest that ENO1 binds TLR4 but not in the same manner as LPS."
27025255
reach
"These results suggest that ENO1 binds TLR4 to induce a pro inflammatory response."
27025255
sparser
"Further to our present results that show ENO1 binding to TLR4, it would be interesting to study the direct interaction of ENO1 TLR4 and CD14 by surface plasmon resonance technology for better understanding of ENO1 action and to highlight the specific pathways involved."
27025255
IL1B affects CD44
| 2 7
IL1B increases the amount of CD44.
| 7
IL1B increases the amount of CD44. 7 / 7
| 7
reach
"Therefore, it is very likely that CD44 is related to hyaluronic acid production in human uterine cervix.Our study is the first report that IL-1beta increases the expression of CD44 mRNA in cultured human cervical fibroblasts."
16219515
reach
"IL-1beta, at concentrations from 1 to 100 pg/ml, stimulated the expression of CD44 mRNA in a dose dependent manner."
16219515
reach
"Expression of CD44 mRNA induced by interleukin-1beta in human cultured uterine cervical fibroblasts."
16219515
reach
"Role of activating protein-1 and high mobility group-I (Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells."
10657993
reach
"Northern analysis showed that IL-1beta promoted a dose- and time dependent induction of CD44 mRNA which reached 6.6-fold after 48 h, and nuclear run-on analysis showed that IL-1beta increased the rate of CD44 gene transcription within 8 h of stimulation."
9685385
reach
"Regulation of CD44 gene expression by the proinflammatory cytokine interleukin-1beta in vascular smooth muscle cells."
9685385
reach
"TG2 overexpression in MCF7 cells increased the surface expression of breast cancer stem cell marker CD44, and IL-1beta stimulation of MCF7_TG2 breast cancer cells further increased CD44 expression (Additional file 1 : Figure S3)."
27609180
IL1B binds CD44.
| 2
CD44 binds IL1B. 2 / 2
| 2
sparser
"Despite lack of increased expression of CD44, or expression of novel splice variants, we have demonstrated increased binding of exogenous fl-HA by CD44 following stimulation with either IL-1β or 25mM -glucose."
12798349
sparser
"Furthermore, blunted crystal phagocytosis was associated with attenuated induction of IL-1β expression and production by CD44 deficient macrophages."
32238827
GRN affects GFRA2
| 7 2
GFRA2 binds GRN. 9 / 9
| 7 2
sparser
"Functional studies also showed that PGRN binds to GFRA2 in vitro."
29724592
reach
"Co-immunoprecipitation experiments in HEK293T cells were done to test for a direct interaction between GFRA2 and progranulin."
29724592
sparser
"We next hypothesized that GFRA2 might directly interact with PGRN and serve as a receptor for PGRN."
29724592
sparser
"Co-immunoprecipitation experiments in HEK293T cells were performed to test for a direct interaction between GFRA2 and PGRN"
29724592
sparser
"No effect of rs36196656 on plasma and cerebrospinal fluid PGRN levels was detected by ELISA; however, co-immunoprecipitation experiments in HEK cells did suggest a direct binding of PGRN and GFRA2."
29724592
sparser
"In-vitro, we obtained evidence of a direct binding of PGRN to GFRA2 which could suggest that GFRA2 may be a signaling receptor for PGRN; however, future experiments both in vitro and in vivo will be needed to determine the functional consequences of this interaction."
29724592
sparser
"Co-immunoprecipitation experiments in HEK293T cells were done to test for a direct interaction between GFRA2 and progranulin."
29724592
reach
"No effect of rs36196656 on plasma and CSF progranulin concentrations was detected by ELISA; however, co-immunoprecipitation experiments in HEK293T cells did suggest a direct binding of progranulin and GFRA2."
29724592
sparser
"No effect of rs36196656 on plasma and CSF progranulin concentrations was detected by ELISA; however, co-immunoprecipitation experiments in HEK293T cells did suggest a direct binding of progranulin and GFRA2."
29724592
YBX1 affects CD44
| 7 1
CD44 binds YBX1. 8 / 8
| 7 1
sparser
"Herein, we report that YB-1 binds the CD44 and CD49f promoters to transcriptionally up-regulate their expressions."
20332234
sparser
"To support the role of YB-1 in regulating a TIC phenotype, we previously determined that YB-1 binds to the promoters of CD44 and CD49f and induces their expression [ xref ]."
23593654
sparser
"YB-1 binds to upstream regulatory regions of the genes encoding CD44 and CD49f, and regulates their expression."
20332234
sparser
"Related to these findings, paclitaxel increased YB-1 binding to the CD44 promoter after 48 hours ( xref ), which also induced P-YB-1 S102 , correlating with activation of the RSK pathway based on higher levels of P-RSK S380 and a second substrate P-GSKβ S9 ( xref )."
20332234
sparser
"Additionally, cytoplasmic YB1 was positively associated with the presence of cancer cells with the CD44 + /CD24 −/low phenotype, which are considered to represent the breast cancer stem cells ( p  = 0.001) ( Table 1 )."
24075827
sparser
"Quantification of this association of CD44 expression with the presence of P-YB-1 S102 was demonstrated by isolating the highest and lowest 10% of CD44-expressing viable SUM 149 cells by FACS sorting and co-staining with CD44 and P-YB-1 S102 antibody."
20332234
sparser
"Overexpressed in breast cancer, Y-box binding protein 1 (YB-1) can be specifically bound to the A/C-rich pre-mRNA regions of CD44 to stimulate the expression of the alternative Exon V4 [ xref ]."
28881705
reach
"Herein, we report that YB-1 binds the CD44 and CD49f promoters to transcriptionally up-regulate their expressions."
20332234
THBS1 affects ITGB3
2 2 4 |
THBS1 binds ITGB3.
2 2 2 |
THBS1 binds ITGB3. 5 / 5
2 1 2 |
omnipath
No evidence text available
2478219
omnipath
No evidence text available
2478219
biogrid
No evidence text available
14963009
biogrid
No evidence text available
2478219
hprd
No evidence text available
2478219
THBS1 binds ITGAV and ITGB3. 1 / 1
1 |
hprd
No evidence text available
2478219
THBS1 activates ITGB3.
2 |
THBS1 activates ITGB3. 2 / 2
2 |
omnipath
No evidence text available
2478219
omnipath
No evidence text available
2478219
THBS1 affects LRP8
| 2 5
THBS1 binds LRP8. 6 / 6
| 1 5
reach
"In contrast to these antiangiogenic phenomena, TSP-1 may also bind ApoER2 (apolipoprotein E receptor 2) and VLDLR to promote neuronal migration."
19360900
reach
"Similarly, we identified Thrombospondin-1 (THBS1), which binds to LRP8 (a.k.a. APOER2) and VLDLR receptors, also receptors for reelin, and seems to play a role in murine postnatal neuronal migration, as well as in synaptogenesis XREF_BIBR, XREF_BIBR."
21445258
reach
"Recently, it was also shown that thrombospondin-1 binds to Apoer2 and VLDLR in the brain where it participates in the chain migration of postnatal neurons along the rostral stream."
20868222
reach
"Blake et al reported that TSP-1 promoted neural cell migration by binding to ApoER2 in postnatal neuronal migration [XREF_BIBR]."
26756218
sparser
"Similarly, we identified Thrombospondin-1 ( THBS1 ), which binds to LRP8 (a."
21445258
reach
"Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration."
18946489
THBS1 binds VLDLR and LRP8. 1 / 1
| 1
sparser
"Recently, it was also shown that thrombospondin-1 binds to Apoer2 and VLDLR in the brain where it participates in the chain migration of postnatal neurons along the rostral stream ( xref )."
20868222
NID1 affects LAMC1
1 1 | 3 2
LAMC1 binds NID1. 7 / 7
1 1 | 3 2
sparser
"Since LAMC1 was selected as a candidate gene based on its physical interaction with NID1, we investigated how the mutations might disrupt this interaction by computational three-dimensional structural homology modeling of the involved domains in the context of known NID1-LAMC1 interaction (pdb ID: 1NPE, xref ).( xref ) The NID1 stop mutation (c."
23674478
hprd
No evidence text available
9733643
reach
"Structural modeling of the NID1 and LAMC1 complex demonstrated that each mutation disrupts the interaction."
23674478
sparser
"Therefore, basement membranes were unable to cell migration, specifically, immune regulatory cells.[ xref ] Moreover, the studies have been reported that genetic variation in LAMC1 gene might alter the interaction between LAMC1 and nidogen during cell development, which is crucial for the development of hepatic cells in the liver.[ xref ] The role of LAMC1 in liver development emphasizes that the gene may have a role in physiology and maintenance of hepatic organs."
30181744
biogrid
No evidence text available
9733643
sparser
"Since LAMC1 was selected as a candidate gene based on its physical interaction with NID1, we investigated how the mutations might disrupt this interaction by computational three-dimensional structural homology modeling of the involved domains in the context of known NID1-LAMC1 interaction (pdb ID: 1NPE, xref ).( xref ) The NID1 stop mutation (c."
23674478
reach
"Structural modeling the NID1 and LAMC1 complex demonstrated that each mutation disrupts the interaction."
23674478
ITGAM affects CD4
| 7
CD4 binds ITGAM. 7 / 7
| 7
sparser
"Protection against SLE-mediated GN in Sle123 →ApoA-I tg mice was associated with reductions in kidney infiltrating CD4 + T cells ( xref ) as well as lower CD11b + monocytic and NIMPR14 + neutrophil infiltrates ( xref )."
26466956
sparser
"We hypothesized that the impairment in CD4 + T cell stimulation associated with CD11b + cells could result from the induction of a suppressor mechanism in CD11b + cells, as suppressor macrophages that induce T cell anergy have previously been described in mice harboring patent schistosome infections xref , xref ."
23556020
sparser
"The inhibitory effect of Sema3E was associated with a reduction of pulmonary CD11b + conventional dendritic cells and regulation of CD4 + T-cell cytokine response."
28634005
sparser
"Administration of 56-5 to mice increased disease progression in an experimental autoimmune encephalomyelitis model and this was associated with a considerable increase in the infiltration of CD4(+) T-cells, CD11b(+) monocytes and F4/80(+) macrophages in the spinal cord."
26187854
sparser
"Our data suggest that the accumulation of GM-CSF-producing CD11b + CD4 + T cells is associated with disease progression in EAE, and that early anti-VLA-4 mAb therapy can prevent the accumulation of GM-CSF + CD11b + CD4 + T cells in the CNS by administration early in the course of disease progression."
24896098
sparser
"Taken together, these data support the early use of anti-VLA-4 mAb treatment to induce neuroprotection in progressive forms of CNS autoimmune disease by blocking the accumulation of GM-CSF-producing CD11b + CD4 + T cells in the CNS."
24896098
sparser
"Since the accumulation of CD11b + TLR-2 + CD4 + T cells in the CNS was associated with increasing neurodegeneration, future experiments are required to assess the pathogenic role of CD11b + TLR-2 + CD4 + T cells in regards to their possible neurodegenerative effector functions."
24896098
IL1B affects CD4
| 3 4
IL1B binds CD4.
| 3 1
CD4 binds IL1B. 4 / 4
| 3 1
sparser
"Factors released from the interaction between IL-1β-competent myeloid cells and CD4 + T cells are highly toxic to neurons."
29358392
sparser
"In xref and xref , it seems likely that IL-1β–expressing cells were associated with CD4 + cells, suggesting that the CD4 + cells might be involved, within the wall of the aneurysm, in activating IL-1β production in the dispersed macrophages and that, in turn, these cells might be activating the CD4 + cells, possibly through the presentation of autoantigens."
10637274
reach
"For Th17 polarizing conditions, CD4 + T cells were stimulated with plate bound anti-CD3 antibody (0.5 mug/ml) and anti-CD28 antibody (1 mug/ml) (BD Pharmingen), anti-IFN-gamma (2 mug/ml), anti-IL-4 (2 mug/ml), IL-1beta (20 ng/ml), and IL-6 (20 ng/ml) (R&D systems) for 72 h. Fn14-Fc was purchased from R&D systems."
22819243
sparser
"Therefore, mPGES-1 stimulates an intercellular interaction between CD4 + T cells by upregulating the autocrine function of IL-1β in activated CD4 + T cells, which release IL-17 to facilitate axonal and myelin damage in EAE mice."
29257087
IL1B increases the amount of CD4.
| 3
IL1B increases the amount of CD4. 3 / 3
| 3
reach
"This down-regulation of CD4 expression by LPS, TNF-alpha, and IL-1 beta occurs at the level of transcription."
7586702
reach
"Conversely, neither LPS nor TNF-alpha and IL-1 beta were able to modulate surface CD4 expression on quiescent or phytohaemagglutinin (PHA)-activated lymphocytes."
7586702
reach
"However, after 24h, IL-1beta significantly increased surface expression of the positive CD4 + T-cell co-stimulatory molecule, ICOS-L 57."
31171837
ADAM15 affects ITGB1
2 4 | 1
ADAM15 binds ITGB1.
2 2 | 1
ADAM15 binds ITGB1. 5 / 5
2 2 | 1
omnipath
No evidence text available
109
omnipath
No evidence text available
9914169
sparser
"However, the competitive binding of an RGD receptor, integrin αvβ3, to the RGD ligand disturbs the adsorption of RGD–pyrene onto the GO surface, resulting in the recovery of pyrene fluorescence."
22919703
hprd
No evidence text available
11882657
hprd
No evidence text available
9914169
ADAM15 activates ITGB1.
2 |
ADAM15 activates ITGB1. 2 / 2
2 |
omnipath
No evidence text available
109
omnipath
No evidence text available
9914169
ITGAM affects TLR4
| 1 5
ITGAM increases the amount of TLR4.
| 3
ITGAM increases the amount of TLR4. 3 / 3
| 3
reach
"To further test if TLR4 expressing skin-resident immune cells are involved in the hBD2 induced itch, we conditionally ablated TLR4 expression in the myeloid cell lineage by generating the LysM cre; Tlr4 f/f mice as we found that TLR4 was primarily expressed by CD11b + / CD11c - dermal macrophages besides a small percentage of dendritic cells and eosinophils (see XREF_SUPPLEMENTARY in this article 's Online Repository at www.jacionline.org)."
28442325
reach
"As shown in XREF_FIG, there was no difference in the percentage of lung CD11b + DCs that expressed TLR4 or TLR5, or the mean fluorescence intensity (MFI) of TLR4 and TLR5 expression by lung CD11b + DCs, in DNA-PKcs fl/fl as compared to DNA-PKcs fl/fl; Cd11c-Cre mice."
25692509
reach
"Thus, modified expression of TLR4 or TLR5 by lung CD11b + DCs does not appear to mediate impaired T cell priming to HDM in DNA-PKcs fl/fl; Cd11c-Cre mice."
25692509
ITGAM binds TLR4.
| 1 2
TLR4 binds ITGAM. 3 / 3
| 1 2
reach
"Binding of dCyaA to CD11b and CD18 integrin may favor a TLR4 and CD11b interaction, or dCyaA could directly interact with TLR4 via its acyl chains."
30037010
reach
"The interaction between LPS, CD11b, and TLR4 is still insufficiently understood."
23673286
sparser
"At the moment, we do not know how NE and CD11b or TLR4 interact to promote the up-regulation of phagoctyosis, but our results of co-localization support the hypothesis that Leishmania induces the rearrangement of cell surface components in macrophages, bringing CR3 and NE to a common signaling platform."
21098233
CD44 affects ADAM15
| 6
CD44 binds ADAM15. 6 / 6
| 6
sparser
"Two OPN receptors, αvβ3 and CD44 have been especially associated with OPN-induced cell migration ( xref , xref , xref , xref )."
11696588
sparser
"Our preliminary studies further suggest that OPN-mediated effects may occur via OPN-CD44 and OPN-αvβ3 interactions (putative OPN-receptors), and/or via MZF1 regulation of TGF-β mRNA (a zinc finger transcription factor) (Mi Z, personal communications)."
24902765
sparser
"OPN is an autocrine/paracrine mediator, interacting with integrin αvβ3 or CD44 for transduction of cell-matrix signaling directed to increase motility, invasion, and angiogenesis ( Oates et al., 1997 )."
21411116
sparser
"Osteopontin facilitates the attachment of osteoclasts to the bone matrix via an interaction with cell surface αvβ3 integrin and CD44, the hyaluronic acid receptor [17] ."
19217889
sparser
"Exogenous OPN works as a pro-inflammatory cytokine by inducing interleukin-12 (IL-12) and suppressing IL-10 expression in macrophages through interactions with αvβ3 integrin and CD44 [ xref ]."
26274807
sparser
"These data provide in vitro mechanistic evidence that p60-c-Src, which could act downstream of Gαs/p72(Syk), associates with LW and CD44 on SSRBCs leading to their interactions with endothelial αvβ3 and CD44, respectively."
26007235
THBS1 affects ITGB1
1 4 |
THBS1 binds ITGB1.
1 2 |
THBS1 binds ITGB1. 3 / 3
1 2 |
hprd
No evidence text available
11358957
omnipath
No evidence text available
15292271
omnipath
No evidence text available
15292271
THBS1 activates ITGB1.
2 |
THBS1 activates ITGB1. 2 / 2
2 |
omnipath
No evidence text available
15292271
omnipath
No evidence text available
15292271
TGFBR1 affects PMEPA1
| 5
TGFBR1 binds PMEPA1. 5 / 5
| 5
reach
"TMEPAI associates with TbetaRI to promote degradation of TbetaRI in the lysosome."
24933703
reach
"GST-TMEPAI interacted with TbetaRI, and bound weakly to Smad2, but not with other Smads or TbetaRII."
24933703
reach
"To verify the interaction between TMEPAI and TbetaRI, an immunoprecipitation experiment was performed."
24933703
reach
"These results indicate that TMEPAI associates with TbetaRI and promotes its lysosomal degradation.To provide evidence for TMEPAI in regulating tumor growth in vivo, A549 cells stably knocked down for TMEPAI or stably overexpressing TMEPAI were injected into BALB/c nude mice."
24933703
reach
"TMEPAI associates with the TGF-beta type I receptor (TbetaRI) and promotes its degradation in the lysosome."
24933703
PTGER3 affects IL1B
| 5
IL1B binds PTGER3. 5 / 5
| 5
sparser
"Clinically, high-gingival crevicular fluid levels of PGE-2, IL-1β, or IL-6 have been associated with their elevated levels in amniotic fluid.[ xref ] The inflammatory response appears to be the privileged pathway of the pathogenic periodontal disease influence on pregnancy, as suggested for other major systemic diseases, including cardiovascular diseases or diabetes.[ xref ]"
25664259
sparser
"Higher levels of GCF IL-1beta and PGE(2) were significantly associated with clinical signs of periodontal disease and independently related to patient-based anthropomorphic measures, behaviours and exposures in community-dwelling adults."
17378884
sparser
"Increased levels of IL-1beta and PGE(2) were associated with body mass index >or=30 kg/m(2)."
17378884
sparser
"IL-6 did increase IL-1beta-induced PGE(2) formation in unstimulated cells but not in cells stimulated with arachidonic acid (AA; 10(-5) M), suggesting that IL-6 effects were mediated at the level of AA release."
11350802
sparser
"The close parallel between the kinetics of COX-2 expression and PGE synthesis indicated that IL-1β-induced PGE formation in TSMCs is mediated through the enhanced expression of COX-2."
12220616
NR3C2 affects MMP13
| 5
MMP13 binds NR3C2. 5 / 5
| 5
sparser
"Whole molecule collagenase and the 27000 Mr fragment bind to type 1 coUagen-Sepharose while the 22 000 Mr fragment exhibits no such binding, suggesting that the C-terminal domain has an important role in the binding of enzyme to substrate."
8086430
sparser
"Interaction of collagenase and low Mr collagenase fragments with gelatin- Sepharose."
8086430
sparser
"Human TIMP-2 eluted from the FPLC column with an apparent Mr of 19667 + 333 but in the presence of 10/xg 45 000 Mr collagenase, a complex was formed with an apparent Mr of 46 333 _ 333 (Fig. 2A)."
8086430
sparser
"Amino acM analys& of SAA degradation products Fig. 5a and b shows that during the degradative process, SAA Mr 14 K is converted to a lower Mr form following treatment with either collagenase or stro- melysin."
8461313
sparser
"Interaction of collagenase and low Mr collagenase fragments with type 1 collagen-Sepharose 10- ',= 6- qP 4 =~ m = 2 o 0 A collagcnase activity of 45 O00-Mr CL "~ : casein/so activity of 22 000-Mr form 10 20 30 40 50 60 Fraction number 1.0 0.9 o 0.8 0.7 -~' a, 0.6 0,5 ~ o."
8086430
ITGB1 affects ITGA1
1 2 2 |
ITGA1 binds ITGB1. 4 / 4
2 2 |
hprd
No evidence text available
8387021
hprd
No evidence text available
10684262
omnipath
No evidence text available
22325954
omnipath
No evidence text available
17671519
ITGA1 bound to ITGB1 binds ITGB1. 1 / 1
1 |
signor
"Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV."
16988024
IL1B affects TRPC3
| 1 4
IL1B increases the amount of TRPC3.
| 4
IL1B increases the amount of TRPC3. 4 / 4
| 4
reach
"Interleukin-1beta specifically upregulated TRPC3 protein expression in myometrial cells without influencing TRPC3 mRNA and had no effect of TRPC4 mRNA or protein [XREF_BIBR]."
19523685
reach
"IL-1 beta did not alter TrpC1, 3, 4, 6, or 7 mRNA expression; but IL-1 beta exclusively up-regulated TrpC3 protein expression (P < or = 0.05)."
15001625
reach
"Specifically, IL1B modulates protein expression of TRPC3 (a putative calcium channel) and SR Ca 2+ -ATPases, initiates spontaneous [Ca 2+] i oscillations and augments calcium influx pathways and a store operated current [XREF_BIBR, XREF_BIBR]."
17570168
reach
"The induction of TRPC3 protein expression by IL1B may in part explain the increase in TRPC3 expression observed in uterine muscle at labour onset and provides a plausible mechanism by which cytokines could induce premature labour."
17570168
IL1B binds TRPC3.
| 1
TRPC3 binds IL1B. 1 / 1
| 1
sparser
"An increased TRPC3 expression was significantly associated with increased expression IL-1β or TNF-α."
18177730
IL1B affects ANTXR1
| 5
ANTXR1 binds IL1B. 5 / 5
| 5
sparser
"IL-1α and IL-1β bind to the IL-1 receptor 1 (IL-1R1) [ xref , xref ]."
28793896
sparser
"IL-1α and IL-1β both bind to the IL-1 receptor 1 (IL-1RI), which is present on almost all cell types, including structural cells such as airway epithelial cells [ xref , xref ]."
22403589
sparser
"Both IL-1α and IL-1β bind to IL-1 receptor 1 (IL-1R1)."
27313051
sparser
"IL-1 signaling is activated when either of the agonistic IL-1 ligands i.e. IL-1α or IL-1β binds to the IL-1 receptor 1 (IL-1R1) which then forms a complex with the IL-1 receptor accessory protein (IL-1RAcP)."
27738319
sparser
"Both IL-1α and IL-1β interact with the IL-1 receptor 1 (IL-1R1) and recruit the IL-1 receptor accessory protein (IL-1R3, formerly IL-1RAcP) to induce a downstream signal via several inflammatory kinases, such as Myd88, ERK, JNK and NFκB, leading to transcription of inflammatory, catabolic genes [ xref - xref ]."
26194067
C3 affects LRP1
1 4 |
C3 binds LRP1.
1 2 |
C3 binds LRP1. 3 / 3
1 2 |
hprd
No evidence text available
10608878
omnipath
No evidence text available
10608878
omnipath
No evidence text available
10608878
C3 activates LRP1.
2 |
C3 activates LRP1. 2 / 2
2 |
omnipath
No evidence text available
10608878
omnipath
No evidence text available
10608878
ATP1A1 affects TRPV1
| 5
ATP1A1 activates TRPV1.
| 4
ATP1A1 activates TRPV1. 4 / 4
| 4
sparser
"We observed that NA directly and potently activates TRPV1 from the intracellular side by lowering the activation threshold for heat, causing channel activation at physiological body temperature."
25752528
sparser
"In a recent study xref , we found that NA activates the capsaicin receptor TRPV1, a heat-activated polymodal cellular sensor that mediates the flushing response upon consumption of spicy food xref xref ."
25752528
sparser
"Our observation of NA-induced TRPV1 activation raises the question whether these TRPV1 homologs can also be targeted by NA."
25752528
sparser
"Our reported study showed that NA directly and strongly activates TRPV1 from the intracellular side xref ."
25752528
ATP1A1 inhibits TRPV1.
| 1
ATP1A1 inhibits TRPV1. 1 / 1
| 1
sparser
"NA inhibits TRPV1 channels activated by capsaicin in sensory neurons."
29304162
ANGPTL2 affects CXCR4
| 5
ANGPTL2 increases the amount of CXCR4. 5 / 5
| 5
reach
"In this study, we showed that ANGPTL2 significantly up-regulated CXCR4 expression in breast cancer cells, which likely enhances their responsiveness to CXCL12."
25773070
reach
"These results suggest that ANGPTL2 may enhance CXCR4 expression in breast cancer cells by increasing ETS1 expression."
25773070
reach
"In the present study, we performed RNA sequence analysis of MDA-MB231 cells harboring ANGPTL2 knockdown (MB231 and miANGPTL2) and found that, relative to control (MB231 and miLacZ) cells, CXCR4 expression significantly decreased, suggesting that ANGPTL2 contributes to CXCR4 expression in breast tumor cells."
25773070
reach
"We next examined the molecular basis for enhanced CXCR4 expression by ANGPTL2."
25773070
reach
"To investigate whether ANGPTL2 increases CXCR4 expression in other breast cancer cells, we generated T47-D lines that constitutively express ANGPTL2 (T47-D and ANGPTL2) and control vector-only lines (T47-D and Control) (XREF_SUPPLEMENTARY)."
25773070
ACP2 affects CD4
| 5
ACP2 activates CD4.
| 4
ACP2 activates CD4. 4 / 4
| 4
sparser
"This might be related to CD4 + LAP + Foxp3 + T and IL-17A + CD4 + T (Th17) cell activation, evidenced by flow cytometry of splenocytes."
30620923
sparser
"This might be related to CD4 + LAP + Foxp3 + T and IL-17A + CD4 + T (Th17) cell activation, evidenced by flow cytometry of splenocytes."
30620923
sparser
"This might be related to CD4 + LAP + Foxp3 + T and IL-17A + CD4 + T (Th17) cell activation, evidenced by flow cytometry of splenocytes."
30620923
sparser
"This might be related to CD4 + LAP + Foxp3 + T and IL-17A + CD4 + T (Th17) cell activation, evidenced by flow cytometry of splenocytes."
30620923
ACP2 binds CD4.
| 1
ACP2 binds CD4. 1 / 1
| 1
sparser
"Finally, we investigated the association of CD4 + Foxp3 + LAP + T cells with tumor stage."
25268580
VLDLR affects SEL1L
| 2 2
SEL1L binds VLDLR. 4 / 4
| 2 2
reach
"We also report that the ERAD adaptor protein SEL1L interact with VLDLR and by CRISPR and Cas9 functional knock-out, provide evidence for a role for SEL1L in the intracellular degradation of VLDLR."
29371607
sparser
"We also report that the ERAD adaptor protein SEL1L interact with VLDLR and by CRISPR/Cas9 functional knock-out, provide evidence for a role for SEL1L in the intracellular degradation of VLDLR."
29371607
reach
"It would be worthwhile to explore the possibility of natural interactions between VLDLR and SEL1L in different cell types, since SEL1L is emerging to have diverse roles in ER homeostasis and lipid metabolism XREF_BIBR, XREF_BIBR."
29371607
sparser
"It would be worthwhile to explore the possibility of natural interactions between VLDLR and SEL1L in different cell types, since SEL1L is emerging to have diverse roles in ER homeostasis and lipid metabolism xref , xref ."
29371607
THBS1 affects CD44
| 3 1
THBS1 binds CD44. 4 / 4
| 3 1
sparser
"TSP-1 interacts with CD44 ligands or HA binding proteins to influence CD44 expression [ xref ]."
21321384
sparser
"These studies indicate a clear connection between the two molecules, and since both CD44 and TSP-1 bind multiple ligands there is a distinct possibility that one or more of these ligands could bridge TSP-1 with CD44, thus, facilitating the DBP binding site complex."
22014686
reach
"However, there are indirect associations between CD44 and TSP-1 that may be relevant to understanding how TSP-1 assists DBP in enhancing chemotaxis to C5a."
22014686
sparser
"We believe that TSP-1 bridges cell surface receptors and facilitates (i.e., accelerates) formation of the DBP binding site complex, but there is no evidence that TSP-1 directly interacts with either CD44 or annexin A2, two molecules that we have previously shown are part of the DBP binding site ( xref )."
22014686
SEL1L affects DERL1
2 | 1 1
SEL1L binds DERL1. 4 / 4
2 | 1 1
biogrid
No evidence text available
23867461
biogrid
No evidence text available
16186509
sparser
"SEL1L associates with Derlin-1, -2, p97, and HRD1, as well as with additional proteins that remain to be identified, some or all of which may also play a role in dislocation."
17043138
reach
"The US11 ERAD pathway is the better characterized and helped identify the Derlin-1 and SEL1L complex, emphasizing the utility of these viral genes in defining ERAD components."
19720873
PLAUR affects ADAM15
| 4
ADAM15 binds PLAUR. 4 / 4
| 4
sparser
"Reported association of uPAR with αvβ3 in cell membrane lipid rafts can foster activation of metalloproteinases that efficiently degrade collagen xref , xref and may thereby contribute to αvβ3 mediated collagen adhesion."
25263164
sparser
"Importantly, uPAR-αvβ3 integrin interaction is indispensible for this vitronectin-induced event xref ."
23843896
sparser
"Immunoprecipitation experiments with lysates of ECFCs and HMVECs, demonstrated the activity of M25 peptide in uncoupling uPAR-integrin αvβ3 interaction (Fig.  xref )."
29615071
sparser
"In contrast, HKa did not prevent the antibody to EGFR from precipitating αvβ3 and vice versa, indicating that EGFR, uPAR and αvβ3 formed a different complex in which EGFR and uPAR bind to αvβ3 integrin."
19483730
M6PR affects CTSD
| 4
CTSD binds M6PR. 3 / 3
| 3
sparser
"In the latter study, the authors demonstrated an interaction between M6PR and pCathD."
26610586
sparser
"Cathepsin D binds to the monocyte/macrophage mannose-6-phosphate receptor [44,45,69], which determines the sorting of cathepsin D between intracellular and plasma membrane components."
7662701
sparser
"Both treatments resulted in suppression of cellular proliferation and the induction of a cell death with no detectable caspase-3 activation or DNA fragmentation, however, it was associated with increased accumulation of cathepsin D, cellular vaculolization, expression of the mannose-6-phosphate receptor, and the autophagy marker LC3-II, all of which are believed to be associated with autophagy."
18775751
SORT1 binds CTSD and M6PR. 1 / 1
| 1
sparser
"Cathepsin H has previously been demonstrated to interact with sortilin, while cathepsin D interacts with both sortilin and the M6PR."
18992238
IL1B affects TRPV4
4 |
Transcriptionally active IL1B increases the amount of TRPV4. 4 / 4
4 |
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
IL1B affects PDGFRA
| 2 2
IL1B phosphorylates PDGFRA.
| 2
IL1B phosphorylates PDGFRA. 2 / 2
| 2
sparser
"IL-1beta-stimulated c-Src, PDGFR, and Akt phosphorylation and proMMP-9 expression were attenuated by the inhibitors of c-Src (PP1), PDGFR (AG1296), and PI3K (LY294002), respectively, or transfection with dominant negative plasmid of c-Src or short hairpin RNAs of PDGFR and Akt."
18315570
sparser
"Src, PDGFR, and PI3K/Akt mediated the effects of IL-1beta because pretreatment with PP1, AG1296, and wortmannin also abrogated IL-1beta-stimulated Src, PDGFR, and Akt phosphorylation, respectively."
17299794
IL1B increases the amount of PDGFRA.
| 2
IL1B increases the amount of PDGFRA. 2 / 2
| 2
reach
"Collectively, these findings support the notion that C/EBPdelta mediated increase in PDGFR-alpha expression by IL-1beta is involved in smooth muscle cell hyperplasia by partial deletion of XBP1."
25373918
reach
"Active CREB prevents activation of PDGFRalpha promoter-luciferase reporter activity by CCAAT and enhancer binding protein-delta (C/EBPdelta), shown to mediate IL-1beta stimulation of PDGFRalpha expression."
12130557
IL1B affects HRH1
| 4
IL1B binds HRH1.
| 2
HRH1 binds IL1B. 2 / 2
| 2
sparser
"The same signalling pathway is involved in the interactions between histamine, interleukin-1beta, and interleukin-6, where NGF secretion is amplified."
16884695
sparser
"In this review, the biochemical mechanisms of histamine-stimulated NGF synthesis and secretion, and interactions between histamine, interleukin-1beta, and interleukin-6 are discussed."
16884695
IL1B activates HRH1.
| 2
IL1B activates HRH1. 2 / 2
| 2
sparser
"Moreover, an experimental study of central administration of interleukin-1β in rats demonstrated that interleukin-1β may stimulate synthesis and release of hypothalamic histamine at presynaptic terminals by activation of histidine decarboxylase (a histamine-synthesizing enzyme) and thus facilitate the degradation of extracellular histamine by the activation of histamine-N-methyltransferase (a degrading enzyme). xref These results indicate that interleukin-1β activates neural histamine turnover in the hypothalamus."
22505826
sparser
"Moreover, interleukin-1beta may activate the turnover of hypothalamic neural histamine."
20304332
IL1B affects CNR1
| 4
IL1B increases the amount of CNR1. 4 / 4
| 4
reach
"Next, we examined a possibility that the male specific upregulation of CB1 expression by IL-1beta can be mediated by the differential expression of AR in TG between the two sexes."
24055403
reach
"Interleukin-1 beta (IL-1beta), a proinflammatory cytokine, upregulated CB1 mRNA expression in TG of male rats."
24055403
reach
"In this study, however, we demonstrated that the IL-1beta induction of CB1 expression was prevented only in the presence of flutamide, but not ICI 182,780."
24055403
reach
"In this study, we confirmed that IL-1beta application reliably and significantly increases CB1 expression in TG primary cultures prepared from intact male rats (XREF_FIG)."
24055403
IL1B affects ABCA1
4 |
Transcriptionally active IL1B decreases the amount of ABCA1. 4 / 4
4 |
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
IGF2R affects CTSD
1 | 2 1
CTSD binds IGF2R. 4 / 4
1 | 2 1
hprd
No evidence text available
15258139
reach
"As shown in XREF_SUPPLEMENTARY, 86% of the Ctsk activity and 16% of the Ctsd activity from WT lysates bound the CI-MPR column."
26404503
sparser
"Newly synthesized CTSD binds CI-M6PR in the TGN and is subsequently translocated into endosomes (Figure xref )."
26973516
sparser
"Interestingly, when analyzing the cathepsins' interaction with the CI-MPR, the authors observed that, unlike cathepsin H, which bound exclusively to sortilin, cathepsin D was also able to bind to the CI-MPR."
22884962
ENO1 affects CD47
| 2 2
CD47 binds ENO1. 4 / 4
| 2 2
sparser
"The interaction between CD47 and ENO1 was verified by co-immunoprecipitation (co-IP)."
32226539
sparser
"Our mechanistic investigations demonstrated that CD47 interacted with ENO1 and protected it from ubiquitin-mediated degradation, subsequently promoting glycolytic activity and phosphorylation of ERK in CRC cells."
32226539
reach
"Our mechanistic investigations demonstrated that CD47 interacted with ENO1 and protected it from ubiquitin mediated degradation, subsequently promoting glycolytic activity and phosphorylation of ERK in CRC cells."
32226539
reach
"The interaction between CD47 and ENO1 was verified by co-immunoprecipitation (co-IP)."
32226539
ATP6AP2 affects ATP6AP1
3 | 1
ATP6AP2 binds ATP6AP1. 4 / 4
3 | 1
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
26496610
sparser
"Messenger RNA (mRNA) expression of ATP6AP1- and ATP6AP2 -mutant forms was detected in all ATP6AP1- and ATP6AP2- mutant GCTs analyzed by RNA sequencing and/or complementary DNA (cDNA) sequencing, respectively (Supplementary Figs.  xref , d)."
30166553
YBX1 affects PLAUR
| 2 1
YBX1 binds PLAUR. 3 / 3
| 2 1
sparser
"The amount of uPAR-YB-1 interactions was also significantly reduced (to 45%, p=0.001) following the uPAR downregulation in comparison to the control cells (Figure xref and xref )."
27286449
reach
"UPAR directly interacts with Cyr61 and with YB-1 in the MDA-MB-231 cells."
27286449
sparser
"The proximity ligation assay was conducted to visualize the interaction of uPAR with either Cyr61 or YB-1 based on a co-localization of target proteins in close proximity (30-40 nm)."
27286449
YBX1 affects GRIA2
| 1 2
GRIA2 binds YBX1. 3 / 3
| 1 2
reach
"YB-1 binds to GluR2 mRNA and CaM1 mRNA in the brain and regulates their translational levels in an activity dependent manner."
20614234
sparser
"In these fractions, the ratio of YB-1 to its binding GluR2 mRNA was decreased, and ribosome association with the YB-1-bound GluR2 mRNA was increased."
22526143
reach
"These results suggest that in the brain of growing mice, YB-1 binds to GluR2 and CaM1 mRNAs and regulates their translation in an activity dependent manner."
20614234
TYRO3 affects GRN
| 3
TYRO3 binds GRN. 3 / 3
| 3
sparser
"Surface Plasmon Resonance (SPR) analysis confirmed that PGRN inhibited binding of Gas6 to Tyro3 in a concentration-dependent manner (Fig.  xref , left panel)."
29382817
sparser
"The top candidate was Tyro3, and our investigations of this factor revealed that PGRN inhibited binding of Gas6 to Tyro3 (Figs.  xref and xref )."
29382817
sparser
"In contrast to the binding of Gas6 to Tyro3 (Fig.  xref ), PGRN did not bind to Tyro3 by itself (Fig.  xref ), nor did BDNF interact with Tyro3 (Fig.  xref )."
29382817
THBS1 affects SDC4
| 1 2
SDC4 binds THBS1. 3 / 3
| 1 2
reach
"There are indications that binding of TSP-1 to syndecan-4 proteoglycan mediates tubulogenesis and their protection from apoptosis [XREF_BIBR]."
24171112
sparser
"There are indications that binding of TSP-1 to syndecan-4 proteoglycan mediates tubulogenesis and their protection from apoptosis [ xref ]."
24171112
reach
"However, by binding to syndecan-4, TSP-1 can also exert pro angiogenic effects, protecting ECs from apoptosis and stimulating tubulogenesis [XREF_BIBR]."
27713299
THBS1 affects CD4
| 1 2
THBS1 binds CD4. 3 / 3
| 1 2
reach
"Given the lack of empirical data and the complexity of the signaling processes, we set out here to interrogate potential mechanisms for the inhibition of VEGF and VEGFR2 signaling to ERK1/2 and calcium by TSP1 and CD4 interaction utilizing a detailed rule based model of VEGF signaling to ERK1/2 and calcium incorporating VEGFR2, the co-receptor NRP1, and the detailed dynamics of the receptors."
28220078
reach
"Additionally, TSP-1 binds CD4 to block HIV entry into target cells."
23772613
sparser
"Additionally, TSP-1 binds CD4 to block HIV entry into target cells ( xref )."
23772613
SORT1 affects CTSD
| 1 2
SORT1 binds CTSD. 2 / 2
| 2
reach
"In mammals, cathepsin D (aspartyl protease), prosaposin C and acid sphingomyelinase can also interact with their receptor sortilin via stretches of amino acids."
27284057
reach
"Cathepsin H has previously been demonstrated to interact with sortilin, while cathepsin D interacts with both sortilin and the M6PR."
18992238
SORT1 binds CTSD and M6PR. 1 / 1
| 1
sparser
"Cathepsin H has previously been demonstrated to interact with sortilin, while cathepsin D interacts with both sortilin and the M6PR."
18992238
SORT1 affects APLP2
| 1 2
SORT1 binds APLP2. 3 / 3
| 1 2
reach
"Using chemiluminescence proximity and co-immunoprecipitation assays, as well as biosynthetic analysis, we discovered that sortilin binds and stabilizes APLP2, and hence could regulate its intracellular functions on other targets."
26085104
reach
"Amyloid precursor like protein 2 (APLP2) interacts with sortilin, and when complexed, degradation is favored by PCSK9 [XREF_BIBR]."
26780014
sparser
"Using chemiluminescence proximity and co-immunoprecipitation assays, as well as biosynthetic analysis, we discovered that sortilin binds and stabilizes APLP2, and hence could regulate its intracellular functions on other targets."
26085104
SEL1L affects AMFR
1 | 1 1
SEL1L binds AMFR. 3 / 3
1 | 1 1
biogrid
No evidence text available
26424800
reach
"Hrd1, but not gp78, forms a complex with SEL1L and OS-9 that facilitates the degradation of substrate proteins by the UPS."
23097496
sparser
"Derlin-1 bound to mutant and WT YOD1 with a similar affinity ( xref , third panel, compare lane 6 with lane 5), whereas gp78, Sel1L, and Derlin-2 (another ERAD membrane component) did not interact with either WT or mutant YOD1 ( xref , second, fourth, and fifth panels, lanes 5 and 6)."
24068323
PLAUR affects ENO1
| 2 1
ENO1 binds PLAUR. 3 / 3
| 2 1
reach
"In this study, we demonstrated that surface ENO1 interacted with plasminogen, uPA and uPAR on the PE089 and LLC and luc lung cancer cell lines."
23894455
sparser
"To directly examine the ability of these molecules to interact, we performed a cell-free dot blotting assay and found that ENO1, uPA, and uPAR interact with each other, while plasminogen only interacts with ENO1 ( xref )."
23894455
sparser
"ENO1 was able to interact with uPA, and uPAR; resulting in augmentation of cell migration and invasion."
28415822
NPTN affects FGFR1
| 1 2
NPTN binds FGFR1. 3 / 3
| 1 2
reach
"Recently, it was demonstrated that neuroplastin binds to and activates fibroblast growth factor receptor 1 (FGFR1) XREF_BIBR, and it may have a function in FGF signaling in hESCs."
21829537
sparser
"Furthermore, we identify a sequence motif in the Ig2 module of Np55 interacting with FGFR1 and show that a synthetic peptide encompassing this motif, termed narpin, binds to and activates FGFR1."
19952283
reach
"Recently, it was demonstrated that neuroplastin binds to and activates fibroblast growth factor receptor 1 (FGFR1) XREF_BIBR, and it may have a function in FGF signaling in OBNSC and hESCs."
22485144
LYVE1 affects BSG
| 3
BSG binds LYVE1. 3 / 3
| 3
reach
"Notably, CD147 (also known as emmprin or basigin) is shown to control HA synthesis and interact with the HA receptors CD44 and LYVE-1."
27999774
reach
"These results support interactions between emmprin, LYVE-1 and BCRP on the surface of chemoresistant PEL cells."
21660043
reach
"In summary, this study provides the first description of cooperative interactions between emmprin, LYVE-1 and BCRP in regulating chemotherapeutic resistance, specifically for PEL."
21660043
ITGAV affects ADAM15
1 2 |
ADAM15 binds ITGAV. 2 / 2
2 |
omnipath
No evidence text available
9914169
omnipath
No evidence text available
9914169
ADAM15 binds ITGAV and ITGB3. 1 / 1
1 |
hprd
No evidence text available
11882657
ITGAM affects F3
| 3
ITGAM binds F3.
| 2
F3 binds ITGAM. 2 / 2
| 2
reach
"The physiologic agonists collagen and ADP increased monocyte-platelet and neutrophil-platelet aggregates and increased leukocyte surface Mac-1 and CD11b and surface bound tissue factor, FXa and fibrinogen."
16241954
reach
"Geometric mean fluorescence and per cent positive data were collected for each subpopulation to measure the binding of test antibodies directed at CD42a, tissue factor, coagulation FXa, bound fibrinogen, activated Mac-1, and CD11b."
16241954
ITGAM increases the amount of F3.
| 1
ITGAM increases the amount of F3. 1 / 1
| 1
reach
"TF was expressed by CD11b + / F4/80 + macrophages specifically in the inflammation prone VAD and at higher levels in CD11b + / CD11c + versus CD11b + / CD11c - adipose tissue macrophages (XREF_FIG)."
22019885
ITGAM affects CD44
| 1 2
ITGAM increases the amount of CD44.
| 2
ITGAM increases the amount of CD44. 2 / 2
| 2
reach
"We found that CD44 in 4-month-old mice was highly expressed by all CD11b + CD45 high but not CD11b + CD45 low CNS MPs in WT and 5xFAD mice, suggesting that CD11b + CD45 high CNS MPs may be of peripheral origin but it still remains possible that CD44 expression is upregulated by microglia with aging and in inflammatory states."
29552013
reach
"We also found that CD44, recently suggested as a marker of peripherally derived CNS infiltrating immune cells in mice, was highly expressed by CD11b + CD45 high CNS MPs but not by CD45 low CNS MPs in both WT and 5xFAD mice."
29552013
ITGAM binds CD44.
| 1
CD44 binds ITGAM. 1 / 1
| 1
sparser
"Fig. 6 E shows that CD44 expression is closely associated with CD11b expression in leukemia cells treated with cyclopamine (correlation coefficient r = 0.76)."
20971508
IL2RG affects ADAM15
| 3
ADAM15 binds IL2RG. 3 / 3
| 3
sparser
"Since it is known that γC binds and activates endothelial αvβ3, a transmembrane integrin receptor involved in intracellular signaling mediated by the tyrosine kinases FAK and Src, we hypothesized that γC alters endothelial barrier function by activating the FAK-Src pathway leading to junction dissociation and RhoA driven cytoskeletal stress-fiber formation."
32352989
sparser
"Since FAK has be implicated in integrin-mediated barrier dysfunction [ xref ] and previous experiments denote the binding of γC to integrin αvβ3 [ xref ], we sought to deduce the role of FAK in γC-induced microvascular hyperpermeability."
32352989
sparser
"The current study supports a direct binding interaction between γC and αvβ3."
19122172
IL1B affects ITGB8
| 3
IL1B increases the amount of ITGB8. 3 / 3
| 3
reach
"Here we report the mechanism of increased ITGB8 expression by IL-1beta."
21878622
reach
"IL-1beta activates Itgb8 expression by chromatin remodeling and exposure of binding sites for additional transcription factors, and the expression of Itgb8 in different cell types corresponds with the chromatin state of the Itgb8 core promoter."
27481847
reach
"We have previously shown that the proinflammatory cytokine interleukin-1beta (IL-1beta) increases ITGB8 expression on lung fibroblasts, which increases alphavbeta8 mediated TGF-beta activation in fibrosis and pathologic inflammation."
21878622
IL1B affects IFNGR1
3 |
Transcriptionally active IL1B increases the amount of IFNGR1. 3 / 3
3 |
biopax:ctd
No evidence text available
21878375
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
20816778
IGF1R affects ADAM15
1 | 2
IGF1R binds ADAM15.
| 2
ADAM15 binds IGF1R. 2 / 2
| 2
sparser
"Αvβ3 and IGF1R did not interact on the cell surface, but WT IGF1 potentiated the association."
28190785
sparser
"The association of αvβ3 and IGF1R has recently been studied in bimolecular fluorescence complementation (BiFC) studies using β3 tagged with YFP1-158 and IGF1R tagged with YFP159-299 [14] ."
28190785
IGF1R phosphorylates ADAM15.
1 |
IGF1R phosphorylates ADAM15 on Y735. 1 / 1
1 |
omnipath
No evidence text available
17570479
HLA-A affects DERL1
2 1 |
DERL1 binds HLA-A. 3 / 3
2 1 |
biogrid
No evidence text available
15215855
biogrid
No evidence text available
21245296
hprd
No evidence text available
15215855
CD83 affects CD4
| 1 2
CD83 binds CD4.
| 1 1
CD4 binds CD83. 2 / 2
| 1 1
reach
"Interestingly, we could not demonstrate binding of naive CD4 + or CD8 + T cells to CD83 (data not shown)."
11748282
sparser
"The highly co-localized expression of CD83 and CD25 on CD4 + T cells suggests that the expression of CD83 is closely associated with the differentiation of CD4 + T cells into iTreg cells upon activation."
25997495
CD83 increases the amount of CD4.
| 1
CD83 increases the amount of CD4. 1 / 1
| 1
reach
"However, CD2 is expressed only at low levels by mature dendritic cells while it is expressed at high levels by T cells, and CD4 is expressed by " immature " blood dendritic cells but not mature CD83 + dendritic cells."
23129155
YBX1 affects PDGFRB
| 2
YBX1 binds PDGFRB. 2 / 2
| 2
sparser
"ChIP sequencing and RNA sequencing identified PDGFR-β as a candidate target of YB-1, and the result was confirmed by ChIP-PCR, which indicated that YB-1 was able to directly bind to the PDGFR-β promoter."
28928774
sparser
"The ChIP-sequencing approach suggested that YB-1 directly bound to the promoter region of PDGFR-β ranging from the site 61044456 to 61044670 on chromatin 18, −640 bp from the transcription start site, and ChIP-PCR confirmed that the PCR product is of the expected size, as shown in Figures xref and xref ."
28928774
YBX1 affects F3
| 2
F3 binds YBX1. 2 / 2
| 2
sparser
"Chromatin immunoprecipitation (ChIP) analysis demonstrated that hypoxia promoted the selective binding of YB-1 to the F3 region (lower left), and that T315 abrogated this binding (lower right)."
25821081
sparser
"Having established that both NFIB and YBX1 interact with the ESR1/FOXA1 TF complex, we asked whether NFIB and YBX1 are able to influence the transcriptional activity of ESR1."
29180470
YBX1 affects CXCR4
1 | 1
YBX1 increases the amount of CXCR4.
1 |
YBX1 increases the amount of CXCR4. 1 / 1
1 |
trrust
No evidence text available
17072343
YBX1 binds CXCR4.
| 1
CXCR4 binds YBX1. 1 / 1
| 1
sparser
"Following on from our basic study dealing with microarray analyses of YB-1-associated gene expression in ovarian cancer cells, we examined whether nuclear localization of YB-1 is associated with the expression of CXCR4, a vault protein named lung resistance-related vault protein (LRP/MVP), phosphorylated Akt (p-Akt) or P-glycoprotein (P-gp) in human ovarian carcinoma."
17459055
VDAC2 affects RPN1
2 |
RPN1 binds VDAC2. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
22939629
VDAC1 affects RPN1
2 |
RPN1 binds VDAC1. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
29128334
VDAC1 affects ATP1A1
2 |
VDAC1 binds ATP1A1. 2 / 2
2 |
biogrid
No evidence text available
29128334
biogrid
No evidence text available
26344197
TRPA1 affects IL1B
| 1 1
TRPA1 binds IL1B. 2 / 2
| 1 1
reach
"In addition to the mechanisms described above, a more direct interaction between TRPA1 and IL-1beta in MSU crystal induced inflammation is possible, as TRPA1 activation has been reported to enhance IL-1beta production in keratinocytes [XREF_BIBR], and a similar effect was found in the present study in the air-pouch model."
25658427
sparser
"In addition to the mechanisms described above, a more direct interaction between TRPA1 and IL-1β in MSU crystal-induced inflammation is possible, as TRPA1 activation has been reported to enhance IL-1β production in keratinocytes [ xref ], and a similar effect was found in the present study in the air-pouch model."
25658427
TNFRSF1A affects IL1RN
| 2
TNFRSF1A binds IL1RN. 2 / 2
| 2
sparser
"Several investigators also found increases in sTNFR1 in the serum of SZ patients. xref reported association of TNFR1 and IL-1RA with general severity of psychotic symptoms in SZ."
25749018
sparser
"Hope et al. (2013) reported association of TNFR1 and IL-1RA with general severity of psychotic symptoms in SZ."
25749018
TLR4 affects BST2
| 2
BST2 binds TLR4. 2 / 2
| 2
sparser
"This decrease in TLR4 mRNA was associated with decreased surface expression of TLR4/MD2 complex, measured by flow cytometry (66 ± 14%, n=4, p <0.03) ( xref )."
20861358
sparser
"This study was aimed to assess the effects of BUD, ACL and FO in bronchial epithelial cells exposed to cigarette smoke extract (CSE) by evaluating: a) Expression of TLR4 and survivin and LPS binding by flow cytometry; b) expression of HDAC2, HDAC3, SIRT1 and FoxO3 and activation of the ERK 1/2 pathway by western blot; c) IL-8 mRNA levels and release by Real Time-PCR and ELISA, respectively."
30659954
TLR4 affects ATP6AP1
| 2
TLR4 binds ATP6AP1. 2 / 2
| 2
sparser
"The interaction between neurotransmitter NMDA receptor subunit 1 (GluN1) and immune receptor TLR4 in N9 and EOC 20 microglial cells was examined in the present study."
29286078
sparser
"The aim of the present study was to determine whether LPS induces interactions between the Toll-like receptor 4 (TLR4) and the ionotropic glutamate receptor N-methyl-D-aspartate subunit 1 (GluN1) in N9 and EOC 20 microglial cells."
29286078
THBS1 affects ITGAV
1 1 |
THBS1 binds ITGAV. 1 / 1
1 |
biogrid
No evidence text available
14963009
THBS1 binds ITGAV and ITGB3. 1 / 1
1 |
hprd
No evidence text available
2478219
THBS1 affects F3
| 2
THBS1 binds F3. 2 / 2
| 2
sparser
"However, further studies are required to determine whether TIPE2 participates in the pathogenesis of asthma by interacting with the coagulation substances TF and TSP-1."
29545867
sparser
"The results of the current study indicated that anti-inflammatory TIPE2 levels are associated with levels of the coagulation substances TF and TSP-1."
29545867
TGFBR3 affects ATP1B3
2 |
TGFBR3 binds ATP1B3. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
SLC3A2 affects CD44
1 | 1
SLC3A2 binds CD44. 2 / 2
1 | 1
sparser
"Such analysis with antibodies to CD44 revealed that both xCT and CD98hc indeed physically interact with CD44 ( Figure 5 E)."
21397861
biogrid
No evidence text available
22939629
RPN1 affects OPRM1
2 |
RPN1 binds OPRM1.
1 |
RPN1 binds OPRM1. 1 / 1
1 |
signor
"Ribophorin i (rpni), a component of the oligosaccharide transferase complex, could directly interact with mor. Rpni can be shown to participate in mor export by the intracellular retention of the receptor after small interfering rna knockdown of endogenous rpni."
19289571
RPN1 activates OPRM1.
1 |
RPN1 activates OPRM1. 1 / 1
1 |
signor
"Ribophorin i (rpni), a component of the oligosaccharide transferase complex, could directly interact with mor. Rpni can be shown to participate in mor export by the intracellular retention of the receptor after small interfering rna knockdown of endogenous rpni."
19289571
PTGER4 affects IL1B
| 2
IL1B binds PTGER4. 2 / 2
| 2
reach
"Furthermore, IL-1 beta can interact with NO and PGE2 during steroid genesis [XREF_BIBR]."
24744811
reach
"Following the above concept, we have at- tempted to characterize in vitro the interactions between IL-1B, IL-6, TNF-ot, LTB4 and PGE2, the major pro in- flammatory cytokines and eicosanoids of hp-Mth."
8002047
PTCH1 affects HLA-A
2 |
HLA-A binds PTCH1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
PLXNB2 affects LMAN2
2 |
LMAN2 binds PLXNB2. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
OPRM1 affects HNRNPK
| 2
HNRNPK binds OPRM1. 2 / 2
| 2
sparser
"Heterogeneous nuclear ribonucleoprotein K (hnRNP K) binds to the promoter region of mu-opioid receptor (MOR) to regulate its transcriptional activity."
25361975
sparser
"To determine the physical interaction of hnRNP K, RPA32, αCP1, αCP2, αCP2-KL, and αCP3 with the mouse Oprm1 promoter, EMSAs were performed using in vitro translated [ 35 S]methionine-labeled proteins ( xref ) and a single strand oligonucleotide (NS) ( xref ) derived from the Oprm1 single strand DNA sequence."
18453338
NTRK1 affects HNRNPK
1 | 1
HNRNPK binds NTRK1. 2 / 2
1 | 1
biogrid
No evidence text available
25921289
sparser
"Moreover, the NGF/TrkA-dependent inhibition of cell viability was significantly enhanced by knockdown of hnRNP K using small interfering RNA, demonstrating that hnRNP K is a novel target associated with the regulation of TrkA-dependent SK-N-MC cancer cell death enhanced by NGF."
27229480
NRP2 affects ATP1B3
2 |
NRP2 binds ATP1B3. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
NR3C2 affects BST2
| 2
BST2 binds NR3C2. 2 / 2
| 2
sparser
"Proc Natl Acad Sci, US 73, 2881-2886 46 Darzynkiewicz Z, Traganos F, Staiano- Coico I,, Kapuscin- ski J, Melamed MR (1982) Interactions of rhodamine 123 with living cells studied by flow cytometry."
7693118
sparser
"Cytometry 1, 98-108 30 Darzynkievicz Z, Traganos F, Staiano-Coico L, Kapunscin- ski J, Melamed MR (1982) Interactions of rhodamine 123 with living cells studied by flow cytometry."
8220230
NPC1 affects CTSD
| 1 1
CTSD binds NPC1. 1 / 1
| 1
reach
"It has been recently shown that aspartyl cathepsin CtsD most likely indirectly binds to NPC1 and that NPC1 could modulate CtsD levels and processing [XREF_BIBR]."
27902765
CTSD binds ABCA1 and NPC1. 1 / 1
| 1
sparser
"First, CYCLO stimulated lysosomal proteolytic activity by increasing cathepsin D activity, levels of cathepsins B and D and two proteins known to interact with cathepsin D, NPC1 and ABCA1."
28062666
LRP1 affects APLP2
| 1 1
APLP2 binds LRP1. 2 / 2
| 1 1
reach
"We first confirmed the physical interaction between LDLR, APP, APLP2 and LRP1 with PCSK9 by co-immunoprecipitation and immunoblotting experiments."
28495363
sparser
"We found that PCSK9, when added to the medium of cells in culture or into the circulation in mice, interacts with APP, APLP2 and LRP1 in a specific and reproducible fashion."
28495363
LPAR1 affects ACP2
2 |
ACP2 binds LPAR1. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
KRT1 affects CTSD
| 1 1
CTSD binds KRT1. 2 / 2
| 1 1
sparser
"In the MB-435-based network 2 ( xref ), the involvement of the TNFα/TGFβ signaling axis is associated with RPSA, GLO1, and CTSD interactions with TNF as well as CTSD and KRT1 interactions with TGFB1."
21779361
reach
"In the MB-435-based network 2 (XREF_FIG), the involvement of the TNFalpha and TGFbeta signaling axis is associated with RPSA, GLO1, and CTSD interactions with TNF as well as CTSD and KRT1 interactions with TGFB1."
21779361
JMJD6 affects BST2
| 2
BST2 binds JMJD6. 2 / 2
| 2
sparser
"We quantified the binding of fluorescent Annexin V to accessible phosphatidylserine in the outer cell membrane by cytometry, as a measure of early apoptotic events."
21745822
sparser
"Cytoplasmic free calcium mobilization in platelets, expression of P-selectin, phosphatidylserine, and microparticle formation, measured by whole blood flow cytometry, in hypertensive patients."
16461073
ITGB1 affects ITGAM
| 2
ITGAM binds ITGB1. 2 / 2
| 2
sparser
"Therefore, compared to those in WT or apoE -/- mice on ND, CD11c + monocytes in apoE -/- on HFD were not only increased in number, but also displayed increased granularity with increased expression of CD11b and CD29, which are associated with cell activation."
19433759
sparser
"These CD11c + monocytes contained abundant lipid in the cytoplasm and expressed high levels of CD11b and CD29, which are associated with cell activation."
19433759
ITGB1 affects BSG
2 |
BSG binds ITGB1. 2 / 2
2 |
hprd
No evidence text available
9360995
hprd
No evidence text available
9360995
ITGAM affects LY75
| 1 1
ITGAM increases the amount of LY75.
| 1
ITGAM increases the amount of LY75. 1 / 1
| 1
reach
"Chimeric antibodies against lectin antigen-uptake receptors efficiently target antigen to specific DC subsets, including DCIR2 expressed by CD11b + cDC2 and DEC-205 expressed by CD8 + cDC1 and some migratory DCs."
26070317
ITGAM binds LY75.
| 1
ITGAM binds LY75. 1 / 1
| 1
sparser
"An additional study investigating intratracheal inoculation of Y. pestis showed the interaction of this bacterium with CD11c + DEC205 + CD11b- cells in the airways and lung."
25333059
ITGAM affects CD47
| 1 1
CD47 binds ITGAM. 2 / 2
| 1 1
reach
"Using proximity ligation assay, the authors convincingly demonstrate a physical association between CD11b and CD47 on the retinal MC in the AMD models."
28228273
sparser
"Also, it is unknown whether more efficient association of CFH(Y402H) with CD47-CD11b has a parallel in its complement-inhibiting activity."
28228273
IL31RA affects GRN
| 1 1
IL31RA binds GRN. 2 / 2
| 1 1
reach
"Therefore, even if the GpL domain of GpL-TNF did bind irreversibly to PGRN, a huge surplus of " GpL-free " PGRN would have been available in our experiments to block TNFR1 and TNFR2 binding by GpL-TNF (or by GpL-TNF in complex with PGRN)."
29740434
sparser
"Therefore, even if the GpL domain of GpL-TNF did bind irreversibly to PGRN, a huge surplus of “GpL-free” PGRN would have been available in our experiments to block TNFR1/TNFR2 binding by GpL-TNF (or by GpL-TNF in complex with PGRN)."
29740434
IL2RG affects CAPNS1
1 1 |
CAPNS1 binds IL2RG. 2 / 2
1 1 |
biogrid
No evidence text available
9326644
hprd
No evidence text available
9326644
IL1RN affects F3
| 2
IL1RN inhibits F3.
| 1
IL1RN inhibits F3. 1 / 1
| 1
sparser
"Analysis of the expression kinetics and regulation by IL-1 of the β-glucan-induced TFs identified by the genome-wide gene expression study uncovered the NFKBIZ gene (encoding IκB-ζ) as the earliest expressed, β-glucan-induced, TF that was inhibited by IL-1RA."
25474109
IL1RN binds F3.
| 1
F3 binds IL1RN. 1 / 1
| 1
sparser
"These treatments were also associated with increased IL-1ra, CD142, and VEGF ( xref , xref )."
28321130
IL1B affects SDC4
| 2
IL1B increases the amount of SDC4. 2 / 2
| 2
reach
"Wang et al. have demonstrated that IL-1beta treatment increases syndecan-4 (SDC4) expression and its promoter activity by activating NF-kappaB, leading to enhanced ADAMTS-5 synthesis and aggrecan degradation in human NP cells [72]."
26341894
reach
"Importantly, analysis of human NP tissues showed a strong correlation between levels of SDC4 and ADAMTS-5 with aggrecan neoepitopes, suggesting that an increase in SDC4 expression by cytokines IL-1beta and TNF-alpha contributes to aggrecan turnover in human disease."
26796346
IL1B affects PTGFR
| 2
IL1B increases the amount of PTGFR. 2 / 2
| 2
reach
"Induction of cyclooxygenase-2 and prostaglandin F2alpha receptor expression by interleukin-1beta in cultured human granulosa-luteal cells."
9275047
reach
"The IL-1beta treatment implicated by microarray analysis increased gene expression levels of PTGS-2, PTGFR, NFkappa-B p65, IL-17, and IL-8."
24933116
IL1B affects ITGB1
2 |
Transcriptionally active IL1B decreases the amount of ITGB1. 2 / 2
2 |
biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
HNRNPK affects GRIA1
| 2
GRIA1 binds HNRNPK. 2 / 2
| 2
sparser
"Importantly, on TrkB-Fc infusion, HFS did not affect the interaction of hnRNP K with the GluN1, GluA1, and hnRNP K mRNAs ( xref ), showing a key role for TrkB signaling in the regulation of the RNP interaction with the transcripts after induction of LTP."
29255796
sparser
"In contrast with the effect of BDNF, activation of the receptors for PDGF (PDGFR-β), which also belong to the receptor tyrosine kinase family, did not decrease the interaction of hnRNP K with GluA1, GluN1, and BDNF mRNAs."
29255796
HNRNPK affects CRY1
1 | 1
CRY1 binds HNRNPK. 2 / 2
1 | 1
sparser
"We also do not know whether the hnRNPK that is phosphorylated by ATM is bound to RNA, or whether such phosphorylation affects hnRNPK binding to RNA and vice versa."
23549171
biogrid
No evidence text available
25756610
HLA-A affects ERBB3
2 |
ERBB3 binds HLA-A. 2 / 2
2 |
biogrid
No evidence text available
24189400
biogrid
No evidence text available
26186194
FCGR1A affects IGF1R
| 2
FCGR1A activates IGF1R. 2 / 2
| 2
sparser
"Many years later, Pritichard et al. reported that IGF-I and GD-IgG could bind and activate IGF-IR ( xref )."
20631493
sparser
"Importantly, the finding of an induction by GD-IgG on hyaluronan production in the face of no response to TSH suggests the potential for GD-IgG activating IGF-1R. In aggregate, the reports of van Zeijl et al ( xref ) may share important similarities with that of Smith and Hoa ( xref )."
22632366
F3 affects ADAM15
| 2
ADAM15 binds F3. 2 / 2
| 2
sparser
"In addition to its protease ligands, the extracellular domain of TF binds several β1 integrins as well as αvβ3 and TF regulates integrin function in cell migration through TF cytoplasmic domain signaling [ xref ]."
20434002
sparser
"The extracellular domain of full-length TF binds αvβ3 and several β1 integrin heterodimers [ xref ], and the amino-terminal domain of asTF retains high affinity interactions with integrins α6β1 and αvβ3 to regulate endothelial cell migration, tube formation, and sprouting [ xref ]."
21781267
ENO1 affects EDNRA
| 2
EDNRA binds ENO1. 2 / 2
| 2
sparser
"Ru(PPh(3))(3)HCl reacts with 1,1'-bis(diphenylphosphino)ferrocene (dppf) to give the 16-electron complex Ru(dppf)(PPh(3))HCl (1d), which upon treatment with NaBAr(4)(F), affords [Ru(dppf){(eta(6)-C(6)H(5))PPh(2)}H]BAr(4)(F) (8), in which the PPh(3) ligand binds eta(6) through one of the PPh(3) phenyl rings."
20575584
sparser
"A slightly bulkier m-terphenyl thiolate, SDmp, prevents its nickel complex from forming a Ni-Ni bond, and the mononuclear nickel(I) center of 3 is bound to PPh(3) and SDmp through interactions with the sulfur and a eta(2)-mesityl."
19235981
DMXL2 affects ANTXR1
2 |
ANTXR1 binds DMXL2. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
CXCR4 affects C3
| 2
C3 binds CXCR4. 2 / 2
| 2
sparser
"The present findings in mice had an important clinical correlate in ten patients with proteinuric nephropathy characterized by activated CD24-positive PECs, who exhibited glomerular accumulation of C3 and C3a associated with high expression of both CXCR4 and GDNF in the glomerular lesions."
27345360
sparser
"The migration of PECs induced by C3a was associated with an increased expression (P < 0.05) of CXCR4 ( xref )."
27345360
CXCR4 affects BST2
| 2
BST2 binds CXCR4. 2 / 2
| 2
sparser
"At multiple time points, we measured binding to surface CXCR4 by flow cytometry using 3 anti-CXCR4 antibodies: 12G5, 1D9, and 2B11."
26360610
sparser
"We next examined the binding of HCLX to cell-surface CXCR4 by flow cytometry."
25699419
CNTNAP1 affects ATP1B3
| 2
CNTNAP1 binds ATP1B3. 2 / 2
| 2
reach
"These results demonstrate that CASPR1 binds with ATP1B3 and thereby contributes to the regulation of Na + / K + -ATPase maturation and trafficking to the plasma membrane in BMECs."
30792309
reach
"The binding of CASPR1 with ATP1B3, but not the alpha1 subunit, indicated that CASPR1 binds with ATP1B3 to facilitate the assembly of Na + / K + -ATPase."
30792309
CD44 affects BST2
| 2
BST2 binds CD44. 2 / 2
| 2
sparser
"Treatment of MUC1-positive CD138+ cells from LEN-sensitive Patient 1 with GO-203 was associated with suppression of CD44 expression as determined by flow cytometry ( xref , left; xref )."
28643330
sparser
"Given that circulating CD45 - CD90 + CD44 + cells detected by flow cytometry were associated with early HCC recurrence, circulating cancer stem cell markers may have significant prognostic values in HCC [ xref ]."
24244607
APLP2 affects ADIPOR2
| 2
ADIPOR2 binds APLP2. 2 / 2
| 2
reach
"It is reported that APPL2 can associate with both AdipoR1 and AdipoR2 and negatively regulate adiponectin signaling in muscle cells 26."
22227293
reach
"Here we report that APPL2, an isoform of APPL1 that forms a dimer with APPL1, can interacts with both AdipoR1 and AdipoR2 and acts as a negative regulator of adiponectin signaling in muscle cells."
19661063
APLP2 affects ADIPOR1
| 2
ADIPOR1 binds APLP2. 2 / 2
| 2
reach
"Here we report that APPL2, an isoform of APPL1 that forms a dimer with APPL1, can interacts with both AdipoR1 and AdipoR2 and acts as a negative regulator of adiponectin signaling in muscle cells."
19661063
reach
"It is reported that APPL2 can associate with both AdipoR1 and AdipoR2 and negatively regulate adiponectin signaling in muscle cells 26."
22227293
ADAM15 affects PTK2B
| 1 1
ADAM15 binds PTK2B.
| 1
ADAM15 binds PTK2B. 1 / 1
| 1
trips
"These data demonstrate selective, phosphorylation-dependent interactions of ADAM15 with Src family PTKs and Grb2, which highlight the potential for integration of ADAM functions and cellular signaling."
11741929
ADAM15 activates PTK2B.
| 1
ADAM15 activates PTK2B. 1 / 1
| 1
sparser
"Dock5 enhances the phosphorylation of p130Cas and the two proteins form a complex with Src and Pyk2 that are activated by αvβ3, the major integrin in osteoclasts."
25022758
ZDHHC5 affects GRIA2
| 1
ZDHHC5 palmitoylates GRIA2. 1 / 1
| 1
sparser
"Although DHHC5 does not palmitoylate GluA2 ( xref ), its targets may include other AMPA-R subunits ( xref ), NMDA-Rs ( xref ) or other PDZ domain adaptor proteins ( xref ), all of which are known to be palmitoylated."
22325201
YBX1 affects SORT1
1 |
SORT1 binds YBX1. 1 / 1
1 |
biogrid
No evidence text available
26496610
YBX1 affects NTRK1
1 |
YBX1 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
YBX1 affects NOTCH1
| 1
NOTCH1 binds YBX1. 1 / 1
| 1
sparser
"Interestingly, YB1 does not bind Notch1 and although interactions with Notch2 and Notch4 have not been examined, it is tempting to speculate that YB1 interactions may be specific for Notch3."
20816393
YBX1 affects FKBP3
1 |
FKBP3 binds YBX1. 1 / 1
1 |
biogrid
No evidence text available
22863883
YBX1 affects ERBB3
1 |
YBX1 increases the amount of ERBB3. 1 / 1
1 |
trrust
No evidence text available
19648825
XPR1 affects RAB5C
1 |
XPR1 binds RAB5C. 1 / 1
1 |
biogrid
No evidence text available
26496610
VDAC3 affects RPN1
1 |
RPN1 binds VDAC3. 1 / 1
1 |
biogrid
No evidence text available
26344197
VDAC3 affects ATP1B3
1 |
VDAC3 binds ATP1B3. 1 / 1
1 |
biogrid
No evidence text available
26344197
VDAC3 affects ATP1A1
1 |
VDAC3 binds ATP1A1. 1 / 1
1 |
biogrid
No evidence text available
26344197
VDAC2 affects RAB5C
1 |
VDAC2 binds RAB5C. 1 / 1
1 |
biogrid
No evidence text available
26496610
VDAC2 affects ATP1B3
1 |
VDAC2 binds ATP1B3. 1 / 1
1 |
biogrid
No evidence text available
26344197
VDAC2 affects ATP1A1
1 |
VDAC2 binds ATP1A1. 1 / 1
1 |
biogrid
No evidence text available
26344197
VDAC1 affects SLC3A2
1 |
SLC3A2 binds VDAC1. 1 / 1
1 |
biogrid
No evidence text available
29128334
VDAC1 affects RAB5C
1 |
VDAC1 binds RAB5C. 1 / 1
1 |
biogrid
No evidence text available
26496610
VDAC1 affects BSG
1 |
BSG binds VDAC1. 1 / 1
1 |
biogrid
No evidence text available
29128334
VDAC1 affects ATP1B3
1 |
VDAC1 binds ATP1B3. 1 / 1
1 |
biogrid
No evidence text available
26344197
VAC14 affects BSG
1 |
BSG binds VAC14. 1 / 1
1 |
biogrid
No evidence text available
26186194
VAC14 affects APLP2
| 1
VAC14 binds APLP2. 1 / 1
| 1
reach
"We found that both APLP1 and APLP2 were able to bind Vac14 and PIKfyve, suggesting that all members of the mammalian APP gene family are likely to be PIKfyve complex interactors."
26216398
TRAM1 affects HLA-A
1 |
TRAM1 binds HLA-A. 1 / 1
1 |
biogrid
No evidence text available
19121997
TNFRSF1A affects IL1B
| 1
TNFRSF1A binds IL1B. 1 / 1
| 1
reach
"Previous studies reported that IL1beta and TNFalpha exert toxic effects by binding to their cognate receptors, IL1-R1 and TNFR1, respectively, triggering downstream signaling pathways that activate transcription factors, such as NFkappaB or AP1 which in turn lead to the production of NO and ROS."
19526281
TNFRSF11A affects BST2
| 1
BST2 binds TNFRSF11A. 1 / 1
| 1
sparser
"For the RANK expression analysis, a concordant expression pattern was observed using mAbs in IHC on a variety of positive and negative controls compared with expression analysis tested using other methods, such as flow cytometry using mAbs which bind RANK via distinct epitopes and RT-PCR."
27556008
TMEM87B affects LPAR1
1 |
TMEM87B binds LPAR1. 1 / 1
1 |
biogrid
No evidence text available
26186194
TMEM63B affects RPN1
1 |
RPN1 binds TMEM63B. 1 / 1
1 |
biogrid
No evidence text available
26496610
TMEM63B affects ATP1A1
1 |
TMEM63B binds ATP1A1. 1 / 1
1 |
biogrid
No evidence text available
26496610
TLR4 affects IL1RN
| 1
TLR4 binds IL1RN. 1 / 1
| 1
sparser
"Prior research indicates an interaction between IL-1ra and TLR4 in a mouse model of arthritis, as TLR4 stimulation enhances arthritis severity in IL-1ra deficient mice whereas TLR4 deficiency is protective ( xref )."
30394314
TLR4 affects BSG
| 1
BSG binds TLR4. 1 / 1
| 1
sparser
"Tasquinimod is a small molecule with a quinoline-3-carboxamide structure that binds to S100A9 and blocks its interaction with TLR4, RAGE and EMMPRIN expressed on different subsets of myeloid cells. xref Tasquinimod has been shown to exert immunomodulatory, anti-angiogenic and anti-metastatic properties in preclinical studies. xref "
27471612
TLR4 affects APLP2
| 1
TLR4 binds APLP2. 1 / 1
| 1
reach
"Opposite to our expectation, binding between the Appl2 and TLR4 was not observed."
25328665
THBS1 affects S1PR1
| 1
THBS1 binds S1PR1. 1 / 1
| 1
sparser
"We then performed a ChIP assay to elucidate whether the interaction of mutant p53 with Rad21 affects its binding to the transcription factor-binding site of the S1PR1 and THBS1 genes."
28831167
THBS1 affects NOTCH1
| 1
THBS1 binds NOTCH1. 1 / 1
| 1
reach
"TSP1 binds Notch1 by complexing with Jagged1 [XREF_BIBR] and/or Contactin [XREF_BIBR] to inhibit NPC differentiation into oligodendrocytes, thereby promoting their differentiation into nerve cells."
25624796
THBS1 affects IL6ST
| 1
THBS1 binds IL6ST. 1 / 1
| 1
sparser
"Among other seven genes, gene FCGR2A is associated with SLE, gene HSPA1A is involved in antigen-processing, genes THBS1 and IL6ST are associated with cytokine-cytokine receptor induced signaling, and genes GADD45A, THBS1, and CHEK1 are associated with p53 signaling pathway."
22688425
THBS1 affects CACNA2D1
| 1
THBS1 binds CACNA2D1. 1 / 1
| 1
reach
"Immunoprecipitation with anti-FLAG antibodies revealed that the SD2-alpha2delta-1 interaction was diminished in the presence of GBP (XREF_FIG) suggesting that GBP blocks TSP induced synapse formation by interfering with the interaction between alpha2delta-1 and TSP."
19818485
SSTR2 affects LY9
| 1
SSTR2 binds LY9. 1 / 1
| 1
sparser
"These data suggest that the interaction between lys9 of S-14 and the TM3 asp122 of SSTR2 represents one contact site between S-14 and SSTR2."
7488212
SSTR2 affects C3
| 1
SSTR2 binds C3. 1 / 1
| 1
sparser
"It showed better binding affinity and more interaction with SSTR2 (Figure xref ), as it specifically interacts with SSTR2 at ASP 39 , VAL 106 , GLY 182 , ASN 186 , GLY 187 , TRP 188 and SER 285 by its LYS, ASN, TRP and CYS residues."
29029435
SORT1 affects IL1RN
| 1
SORT1 binds IL1RN. 1 / 1
| 1
reach
"Using chemical cross linking and the yeast two-hybrid system, we show that sortilin interacts with Glut4 and IRAP in the vesicular lumen."
17220298
SLC3A2 affects NTRK1
1 |
SLC3A2 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
SLC3A2 affects LGR4
1 |
SLC3A2 binds LGR4. 1 / 1
1 |
biogrid
No evidence text available
24639526
SLC3A2 affects ITGB1
1 |
SLC3A2 binds ITGB1. 1 / 1
1 |
hprd
No evidence text available
11507094
SIGMAR1 affects ATP6AP1
| 1
SIGMAR1 binds ATP6AP1. 1 / 1
| 1
sparser
"Yeast two hybrid analysis showed that the principle sigma factor RpoD1 interacts with Orf7.5."
32281544
SEL1L affects PTPRO
1 |
SEL1L binds PTPRO. 1 / 1
1 |
biogrid
No evidence text available
27432908
SEL1L affects PTPRE
1 |
SEL1L binds PTPRE. 1 / 1
1 |
biogrid
No evidence text available
27432908
SEL1L affects NTRK1
1 |
SEL1L binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
SEL1L affects ITGB1
1 |
SEL1L binds ITGB1. 1 / 1
1 |
biogrid
No evidence text available
24324549
SDC4 affects ADAM15
| 1
SDC4 binds ADAM15. 1 / 1
| 1
sparser
"Considering that Thy-1 interacts with syndecan-4 and αvβ3, both astrocytic molecules, and that syndecan-4 levels are up-regulated in astrocytes following CNS injury ( xref ), as is also the case for the αvβ3 integrin ( xref ; xref ), the results reported by Fiore and colleagues ( xref ) suggest that the Thy-1/αvβ3 integrin/syndecan-4 complex may also exhibit dynamic catch bond behavior in our model system; however, whether this is indeed the case remains to be determined."
29212879
SCARB2 affects GRN
| 1
SCARB2 binds GRN. 1 / 1
| 1
sparser
"PGRN demonstrated dose-dependent binding and saturation to liquid-phase GCase ( xref c), whereas no direct interaction between PGRN and LIMP2 was detected ( xref c)."
27789271
SCARB2 affects CTSD
| 1
SCARB2 binds CTSD. 1 / 1
| 1
sparser
"The dispersed lysosomes associated with cathepsin D and LIMPII were not colocalized with early endosomes, and these vesicles were not inaccessible to the endocytosed anti-transferrin receptor antibody."
12587997
SCARB1 affects ATP1B3
1 |
SCARB1 binds ATP1B3. 1 / 1
1 |
biogrid
No evidence text available
26186194
S1PR2 affects ACP2
1 |
ACP2 binds S1PR2. 1 / 1
1 |
biogrid
No evidence text available
28514442
S1PR1 affects ACP2
1 |
ACP2 binds S1PR1. 1 / 1
1 |
biogrid
No evidence text available
28514442
RYK affects APLP2
1 |
RYK binds APLP2. 1 / 1
1 |
biogrid
No evidence text available
21875946
RPN1 affects NTRK1
1 |
RPN1 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
RPN1 affects LGR4
1 |
RPN1 binds LGR4. 1 / 1
1 |
biogrid
No evidence text available
24639526
RPN1 affects ERBB3
1 |
RPN1 binds ERBB3. 1 / 1
1 |
biogrid
No evidence text available
12840049
RPN1 affects DERL1
1 |
RPN1 binds DERL1. 1 / 1
1 |
biogrid
No evidence text available
28137758
RPN1 affects CRY2
1 |
RPN1 binds CRY2. 1 / 1
1 |
biogrid
No evidence text available
25756610
RAB5C affects NTRK1
1 |
NTRK1 binds RAB5C. 1 / 1
1 |
biogrid
No evidence text available
25921289
RAB5C affects INSR
| 1
INSR binds RAB5C. 1 / 1
| 1
reach
"Of further interest, the candidate Rab5c (XREF_TABLE) also associates with the IR and this association increases in an insulin regulated (XREF_FIG)."
30300385
RAB5C affects IGF2R
1 |
IGF2R binds RAB5C. 1 / 1
1 |
biogrid
No evidence text available
26496610
RAB5C affects CLCN7
1 |
CLCN7 binds RAB5C. 1 / 1
1 |
biogrid
No evidence text available
26496610
PTPRO affects HLA-A
1 |
HLA-A binds PTPRO. 1 / 1
1 |
biogrid
No evidence text available
27432908
PTPRO affects ATP6AP1
1 |
ATP6AP1 binds PTPRO. 1 / 1
1 |
biogrid
No evidence text available
27432908
PTPRF affects IL1B
| 1
IL1B binds PTPRF. 1 / 1
| 1
sparser
"As shown in xref , LAR was positively associated with IL-1β (r=0.41, p<0.001)."
29436520
PTPRD affects CD83
1 |
CD83 binds PTPRD. 1 / 1
1 |
biogrid
No evidence text available
28514442
PRNP affects APLP2
1 |
APLP2 binds PRNP. 1 / 1
1 |
hprd
No evidence text available
15146195
PMEPA1 affects ANTXR1
| 1
PMEPA1 inhibits ANTXR1. 1 / 1
| 1
sparser
"Subsequent studies have defined that PMEPA1 inhibits TGF-β receptor 1 meditated signaling through a negative feedback loop by sequestering R-Smads [ xref ]."
25883222
PLXNA4 affects DCT
1 |
DCT binds PLXNA4. 1 / 1
1 |
biogrid
No evidence text available
28514442
PLAUR affects MMP13
| 1
MMP13 binds PLAUR. 1 / 1
| 1
sparser
"Third, Endo180 has been reported to interact with two components of the extracellular protease systems, matrix metalloproteinase 13 (MMP-13; collagenase-3) and uPAR."
12223280
PKD1 affects ATP1A1
1 |
ATP1A1 binds PKD1. 1 / 1
1 |
biogrid
No evidence text available
11901144
PEAR1 affects HDGF
| 1
PEAR1 binds HDGF. 1 / 1
| 1
sparser
"PEAR1 interactions with HDGF and PRCC might modulate their cancer-related role and open up for future research of PEAR1 in the tumour biology field."
29614055
PDGFRB affects ADAM15
| 1
ADAM15 binds PDGFRB. 1 / 1
| 1
sparser
"PDGFRβ and the VEGFR2 associate with integrin αvβ3 through the extracellular domain of the β3 subunit, independently from the RTKs phosphorylation, whereas the cytoplasmic and transmembrane regions of β3 subunit are dispensable xref ."
28425453
PDGFRA affects ADAM15
| 1
ADAM15 binds PDGFRA. 1 / 1
| 1
sparser
"In fact, association of PDGFRα to αvβ3 integrin activates the Src kinase Lyn and triggers proliferation on fibronectin support."
24578683
NTSR2 affects GRN
| 1
GRN binds NTSR2. 1 / 1
| 1
sparser
"Two other NT binding sites are G protein-coupled receptors, but NTR1 and NTR2 do not bind PGRN ( xref , xref )."
21092856
NTRK1 affects LMAN2
1 |
LMAN2 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NTRK1 affects HLA-A
1 |
HLA-A binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NTRK1 affects HDGF
1 |
HDGF binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NTRK1 affects GRN
1 |
GRN binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NTRK1 affects ENO1
1 |
ENO1 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NTRK1 affects CPD
1 |
CPD binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NTRK1 affects BSG
1 |
BSG binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NTRK1 affects ATP1A1
1 |
ATP1A1 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NRP1 affects HDGF
| 1
HDGF binds NRP1. 1 / 1
| 1
trips
"Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2."
15695515
NR3C2 affects IL1B
| 1
IL1B binds NR3C2. 1 / 1
| 1
sparser
"Molecular sieve chromatography of TAT-IC-activated serum confirmed that 125I-IL-1 beta became bound to high Mr serum proteins."
1693530
NPY2R affects DMXL2
1 |
DMXL2 binds NPY2R. 1 / 1
1 |
biogrid
No evidence text available
28514442
NOTCH1 affects BSG
| 1
BSG binds NOTCH1. 1 / 1
| 1
sparser
"By analyzing functions of genes in altered chromosomes, we further confirmed that the levels of BSG and NOTCH1 , which are associated with the occurrence and development of leukemia, were increased in these workers."
24993241
NOTCH1 affects ANGPTL2
| 1
ANGPTL2 binds NOTCH1. 1 / 1
| 1
sparser
"Even though we could only observe a modest knockdown of LILRB2 ( xref , second blot, with sh-LILRB2-2 being more effective than sh-LILRB2-1), we saw that in contrast to the control scrambled shRNA transduced cells (sh-CT), which still retained the ANGPTL2-mediated NOTCH cleavage, sh-LILRB2 transduced cells had lost this response with no ANGPTL2-induced NICD formation ( xref , third blot)."
25714926
NLGN3 affects CTSD
1 |
NLGN3 binds CTSD. 1 / 1
1 |
biogrid
No evidence text available
25464930
NALCN affects BST2
| 1
BST2 binds NALCN. 1 / 1
| 1
sparser
"To assess the cellular function of the P2X7 receptor in patients with active disease and healthy controls, we determined the non-selective pore formation induced by ATP by flow cytometry."
22703695
MMP13 affects ITGB3
| 1
ITGB3 binds MMP13. 1 / 1
| 1
sparser
"The interactions between MMP-13, GPVI and αIIbβ3 are sufficient to significantly inhibit washed platelet aggregation and decrease thrombus formation on fibrillar collagen."
30046741
MMP13 affects FGFR1
| 1
FGFR1 binds MMP13. 1 / 1
| 1
sparser
"The chondroprotective effect of FGFR-1 inhibition was largely associated with decreased expression of matrix metalloproteinase 13 (MMP-13) and up-regulation of FGFR-3 in mouse and human articular chondrocytes."
22833219
MMP13 affects DDR1
| 1
DDR1 binds MMP13. 1 / 1
| 1
sparser
"Actually, periostin and MMP13 increase in OA was reported and recombinant periostin induces DDR1-MMP13 relation was also proved in previously."
32330138
M6PR affects ENO1
1 |
ENO1 binds M6PR. 1 / 1
1 |
biogrid
No evidence text available
22658674
M6PR affects ACP2
1 |
ACP2 binds M6PR. 1 / 1
1 |
biogrid
No evidence text available
22939629
LRP1 affects ITGAM
| 1
ITGAM binds LRP1. 1 / 1
| 1
sparser
"Using purified proteins, LRP indeed associated with the alphaMbeta2 complex and the alphaM and alphaL I-domains (K(d, app) approximately 0.5 microM)."
15328156
LRP1 affects IL1RN
| 1
IL1RN binds LRP1. 1 / 1
| 1
sparser
"Golgin-160 likely acts together with p115, another Golgi matrix protein that binds IRAP and LRP1, to sequester GSVs within unstimulated cells [ xref , xref , xref ]."
24114239
LRP1 affects IL1B
| 1
IL1B binds LRP1. 1 / 1
| 1
sparser
"IL-1RtI knockout mice were resistant to the APR induced by peripherally injected murine IL-1 beta, suggesting that it is not the interaction of endogenous IL-1 beta with IL-1RtII that induces an APR to LPS in these mice."
8997368
LRP1 affects ADAM15
| 1
ADAM15 binds LRP1. 1 / 1
| 1
sparser
"tPA-mediated vasocontraction and calcium mobilization from intracellular stores require the formation of a complex between LRP and αvβ3 in vSMCs [ xref ] suggesting a role of LRP-1-mediated integrin signaling."
25514242
LMAN2 affects CACNA2D1
1 |
CACNA2D1 binds LMAN2. 1 / 1
1 |
biogrid
No evidence text available
26186194
LIFR affects IL1RN
| 1
IL1RN binds LIFR. 1 / 1
| 1
sparser
"Indeed, the latter condition is not associated with changes in serum LIFR or IL-1RA levels, but with a different profile of serum IL-6R production."
10674277
LGR4 affects LAMC1
1 |
LGR4 binds LAMC1. 1 / 1
1 |
biogrid
No evidence text available
24639526
LGR4 affects HNRNPK
1 |
LGR4 binds HNRNPK. 1 / 1
1 |
biogrid
No evidence text available
24639526
LGR4 affects DCT
1 |
LGR4 binds DCT. 1 / 1
1 |
biogrid
No evidence text available
28514442
LGR4 affects CPD
1 |
LGR4 binds CPD. 1 / 1
1 |
biogrid
No evidence text available
24639526
LGR4 affects ATP1A1
1 |
LGR4 binds ATP1A1. 1 / 1
1 |
biogrid
No evidence text available
24639526
LAMC1 affects RHO
| 1
LAMC1 activates RHO. 1 / 1
| 1
sparser
"Laminin and fibronectin differentially activate Rho family GTPases through discrete signaling pathways involving the α3β1 and α5β1 integrins ( xref )."
26216901
LAMC1 affects PRNP
| 1
LAMC1 activates PRNP. 1 / 1
| 1
sparser
"PrP c has been shown to stimulate Ca 2+ release from neuronal intracellular stores in response to laminin γ1-chain peptide-dependent activation of endogenous PrP c , as well as stimulate PKC translocation to the plasma membrane in response to either mGluR1a or mGluR5a activation [ xref ]."
25888324
LAMC1 affects ANTXR2
1 |
ANTXR2 binds LAMC1. 1 / 1
1 |
biogrid
No evidence text available
11683410
KRT1 affects HDGF
1 |
HDGF binds KRT1. 1 / 1
1 |
biogrid
No evidence text available
21907836
KIT affects BSG
| 1
BSG binds KIT. 1 / 1
| 1
sparser
"CD147 expression was associated with mutated KIT (p = 0.039), as well as a progressive increase in Fletcher's Risk of Malignancy (p = 0.020)."
22281667
ITGAM affects BMPR1A
| 1
ITGAM increases the amount of BMPR1A. 1 / 1
| 1
reach
"Since BMPR1a is not expressed by CD11b + cells (XREF_FIG) and is largely restricted to GFAP + cells (XREF_FIG) in the injured spinal cord, the increased infiltration of inflammatory cells is an indirect effect reflecting the defect in reactive gliosis."
20130193
INSR affects IL1B
| 1
IL1B binds INSR. 1 / 1
| 1
sparser
"DM2 could potently modulate angiogenesis by the interaction of IL-1β with downstream insulin receptor and upstream androgen receptor."
27918077
INSR affects FCGR1A
| 1
FCGR1A binds INSR. 1 / 1
| 1
sparser
"Free IGF-1 has a short half life, but at high levels it can bind to both the IGFR1 and insulin receptor (IR) to exert an anabolic effect."
25577208
INSR affects ATP1A1
1 |
INSR phosphorylates ATP1A1 on Y10. 1 / 1
1 |
omnipath
No evidence text available
17570479
INSR affects ACP2
| 1
ACP2 binds INSR. 1 / 1
| 1
reach
"LAP is associated with abnormal glucose homeostasis and IR, as well as increased alanine aminotransferase, in healthy people [XREF_BIBR]."
32395444
IL6ST affects IL1B
| 1
IL1B binds IL6ST. 1 / 1
| 1
reach
"Interleukin (IL) -6 functions downstream of IL-1beta and has unique signal pathways : classic- or trans-signaling via membrane bound IL-6R or soluble IL-6R (sIL-6R)."
27863335
IL1RN affects FGFR1
| 1
FGFR1 binds IL1RN. 1 / 1
| 1
sparser
"CLCA4, ANXA9, GPR110, IL1RN, KLK12, PPARD, FLG and HSP90AAl are smoking dependent DEGs whereas GPR110, IL1RN and HSP90AAl are associated with lung cancer FLG is co-expressed with several query genes which are enriched in different cellular growth promoting pathways and FLG together with other genes plays key role in epidermal cell regulation."
26124566
IL1R1 affects ENO1
| 1
ENO1 binds IL1R1. 1 / 1
| 1
reach
"These results suggested that p80, which is generated from ErbB4 and translocates to the nuclei, interacts with alpha-enolase and inhibits neuregulin1 dependent ErbB4 mediated cell proliferation by impairing the c-myc gene transcription."
24955285
IL1B affects NALCN
| 1
IL1B activates NALCN. 1 / 1
| 1
sparser
"In addition, using slow voltage ramps we demonstrated that IL-1beta activates a non-selective cationic current (INSC) with a reversal potential of -38.8 +/- 1.8 mV."
12879863
IL1B affects GRIA1
| 1
GRIA1 binds IL1B. 1 / 1
| 1
sparser
"IL-1β affects various classical neurotransmitter systems, and there is evidence that the NMDA glutamate receptor and IL-1β interact with each other."
29921762
IL1B affects FGFR1
| 1
FGFR1 binds IL1B. 1 / 1
| 1
sparser
"In a mouse model of human breast cancer, fibroblast growth factor receptor 1-induced mammary tumorigenesis is associated with local production of IL-1β and can be blocked by treatment with an IL-1β neutralizing antibody (Reed et al., xref )."
24474192
IL1B affects CRY1
| 1
CRY1 binds IL1B. 1 / 1
| 1
sparser
"Interestingly, although IL1β and IL-18 and their cellular receptors are related proteins, IL-18BP and IL-1βR displayed high specificity towards their targets: IL-18BP was not able to bind IL-1β and vice versa IL-1βR did not bind IL-18 [ xref ]."
20673807
IL1B affects CLIC1
| 1
IL1B increases the amount of CLIC1. 1 / 1
| 1
reach
"The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1beta transcription and activate the NLRP3 inflammasome."
28576828
IL1B affects CASR
| 1
CASR binds IL1B. 1 / 1
| 1
sparser
"The hypocalcemia of critically ill patients with burn injury or sepsis is associated with CASR gene upregulation by TNF-alpha and IL-1beta via kappaB elements, and by IL-6 via Stat1/3 and Sp1/3 elements in the CASR gene promoters, respectively."
27679579
IL1B affects AQP1
| 1
IL1B binds AQP1. 1 / 1
| 1
sparser
"AQP1 deficiency is associated with a marked reduction of both lung IL-1β release and neutrophilic inflammation."
24700466
IL1B affects AGTR1
| 1
AGTR1 binds IL1B. 1 / 1
| 1
sparser
"In this study, we determined whether an interaction between IL-1β and AT1-R in the paraventricular nucleus (PVN) contributes to progression of HF."
24955935
IL15RA affects BST2
| 1
BST2 binds IL15RA. 1 / 1
| 1
sparser
"More importantly, the increased mRNA expression of IL-15Rα was associated with an increased IL-15Rα cell-surface expression as determined by flow cytometry after 48h of incubation with IFN-α with a more than two-fold increase in mean fluorescence intensity (MFI) (, middle panel)."
21813181
IFI30 affects B9D1
1 |
B9D1 binds IFI30. 1 / 1
1 |
biogrid
No evidence text available
26186194
HRH1 affects C3
| 1
C3 binds HRH1. 1 / 1
| 1
sparser
"Elevated C3a, C5a, and histamine have been associated with severe permeability deficits in dengue virus patients and in the development of DHF and DSS [ xref , xref , xref , xref , xref ]."
22952474
HNRNPK affects CUL5
1 |
CUL5 binds HNRNPK. 1 / 1
1 |
biogrid
No evidence text available
21145461
HNRNPK affects CRY2
1 |
CRY2 binds HNRNPK. 1 / 1
1 |
biogrid
No evidence text available
25756610
GRN affects GPR61
| 1
GPR61 binds GRN. 1 / 1
| 1
reach
"Further studies are required to decide whether PEPI binds to GPR61 and whether PEPI plays an important role in the control of gonadotropin secretion from gonadotrophs."
29754010
GRN affects CRY1
1 |
CRY1 binds GRN. 1 / 1
1 |
biogrid
No evidence text available
21988832
GRN affects CACNG5
1 |
CACNG5 binds GRN. 1 / 1
1 |
biogrid
No evidence text available
28514442
GRN affects CACNA1A
1 |
CACNA1A binds GRN. 1 / 1
1 |
biogrid
No evidence text available
21078624
GRIA1 affects C3
| 1
C3 binds GRIA1. 1 / 1
| 1
sparser
"We identified one synonymous and two intronic GRIA1 SNPs associated with E . coli -ASP hypersensitivity on certain ALL subgroups."
26457809
FGFR1 affects ADAM15
| 1
ADAM15 binds FGFR1. 1 / 1
| 1
sparser
"When the FGFR1–FGF2 complex (1FQ9) was superposed on the αvβ3–FGF2 complex, there was little or no steric hindrance, suggesting that FGF2 can simultaneously bind to FGFR1 and αvβ3."
28302677
FCGR1A affects SCARB1
| 1
FCGR1A inhibits SCARB1. 1 / 1
| 1
sparser
"Our findings that anti-SR-BI IgG blocks SR-A −/− microglial adhesion to fAβ-containing matrices by ∼40% while fucoidan blocks adhesion of both SR-A +/+ and SR-A −/− microglia by ∼75% ( Fig. 3a ) suggest that, assuming complete inhibition of SR-BI by anti-SR-BI IgG, scavenger-like receptors other than SR-A and SR-BI (e.g. RAGE, LRP, LOX-1, Fcγ-receptors ( Terry, 1999 )), also promote adhesion of microglia to fAβ-containing surfaces, and that unlike SR-A and SR-BI some of these other receptors are not inhibited by fucoidan."
11240025
FCGR1A affects DNER
| 1
FCGR1A inhibits DNER. 1 / 1
| 1
sparser
"Furthermore, 2PAPB-PreS–induced IgG inhibited Bet v 1–induced basophil activation in allergic patients and CD23-facilitated allergen presentation."
23440415
F3 affects ATP6AP1
| 1
F3 binds ATP6AP1. 1 / 1
| 1
sparser
"CF3-4M, CF2-4M, and HX2M preferentially bound perchlorate over perrhenate or thiocyanate (additional data provided in the xref )."
28809217
F3 affects APLP2
| 1
F3 binds APLP2. 1 / 1
| 1
sparser
"The secreted form of APLP2-TF was immunoprecipitated from the conditioned medium with an anti-FLAG antibody and then digested in vitro with TEV protease."
21695060
F2RL2 affects BSG
| 1
BSG binds F2RL2. 1 / 1
| 1
sparser
"To further verify the association between CD147 and Par3 expression, immunohistochemical analysis of 30 cases of HCC tissues was performed and indicated that CD147 expression was negatively associated with Par3 expression ( r = –0.3970, P = 0.029; Fig. xref C)."
29356040
ENO1 affects EFEMP1
1 |
EFEMP1 binds ENO1. 1 / 1
1 |
biogrid
No evidence text available
22658674
ENO1 affects EBP
1 |
EBP binds ENO1. 1 / 1
1 |
biogrid
No evidence text available
22658674
ENO1 affects CUL5
1 |
CUL5 binds ENO1. 1 / 1
1 |
biogrid
No evidence text available
21145461
ENO1 affects CD4
1 |
CD4 binds ENO1. 1 / 1
1 |
biogrid
No evidence text available
15047060
ENO1 affects ATP6AP2
1 |
ATP6AP2 binds ENO1. 1 / 1
1 |
biogrid
No evidence text available
26496610
DCT affects SSTR2
| 1
DCT increases the amount of SSTR2. 1 / 1
| 1
reach
"To determine whether SSTR2 expression levels correlated with successful peptide-receptor-based imaging, clinical data from the University of Iowa Neuroendocrine Tumor Registry Database were examined and patients from the highest and lowest quartiles of SSTR2 expression by dCT were compared (XREF_TABLE)."
24238043
DCT affects CHRM2
| 1
CHRM2 binds DCT. 1 / 1
| 1
reach
"When compared to the general population, this genetic polymorphism was not found to be more common in alcohol dependence per se, which excludes the possibility of spurious association between CHRM2 and DT."
29478862
CUL5 affects CTSD
1 |
CTSD binds CUL5. 1 / 1
1 |
biogrid
No evidence text available
21145461
CTSD affects CD4
1 |
CD4 binds CTSD. 1 / 1
1 |
hprd
No evidence text available
11581410
CRY2 affects ATP1A1
1 |
CRY2 binds ATP1A1. 1 / 1
1 |
biogrid
No evidence text available
25756610
CPD affects CHRNB4
| 1
CHRNB4 binds CPD. 1 / 1
| 1
reach
"Previous associations between CHRNA3, CHRNA5, CHRNB4 and CPD in EAs were replicated."
27613895
CPD affects CHRNA3
| 1
CHRNA3 binds CPD. 1 / 1
| 1
reach
"Previous associations between CHRNA3, CHRNA5, CHRNB4 and CPD in EAs were replicated."
27613895
CLIC1 affects ADAM15
| 1
ADAM15 binds CLIC1. 1 / 1
| 1
sparser
"We previously demonstrated that CLT1-fibronectin complexes are taken up into angiogenic endothelium through interaction with integrin αvβ3 and CLIC1 and that this interaction induces autophagic cell death ( xref )."
23204394
CHRNA7 affects BST2
| 1
BST2 binds CHRNA7. 1 / 1
| 1
sparser
"We assayed interaction of the amyloid beta peptide with SH-SY5Y cells using flow cytometry for the detection of the fluorescence signal of FITC-labelled A β 1–42 peptide after 5, 10, 15, and 30 min and after 1, 3, 18, and 24 h."
29576854
CD83 affects NRP1
| 1
CD83 increases the amount of NRP1. 1 / 1
| 1
reach
"Treg associated molecules including CD25, cytotoxic T lymphocyte antigen-4 (CTLA-4), glucocorticoid induced TNFR family related gene (GITR), Helios and neuropilin-1 (NRP-1) as well as forkhead box protein 3 (FOXP3) were specifically expressed by these CD83 (+) T cells."
25151500
CD83 affects IFNGR1
| 1
CD83 inhibits IFNGR1. 1 / 1
| 1
sparser
"Here, we show that CD83 inhibits proliferation and production of IL-2 and IFN-γ by T cells, and the inhibitory effect of CD83 is mediated by monocytes."
22065790
CD83 affects BMPR2
1 |
BMPR2 binds CD83. 1 / 1
1 |
biogrid
No evidence text available
28514442
CD83 affects BMPR1A
1 |
BMPR1A binds CD83. 1 / 1
1 |
biogrid
No evidence text available
28514442
CAPNS1 affects AGTRAP
1 |
AGTRAP binds CAPNS1. 1 / 1
1 |
biogrid
No evidence text available
25416956
BST2 affects KCNH2
| 1
BST2 inhibits KCNH2. 1 / 1
| 1
sparser
"To test for such a scenario, the population of K562 cells with degraded DNA (subG 1 population) was determined in dependence on hERG1 inhibition (0 or 1 µM E4031) by flow cytometry (propidium iodide Nicoletti staining) 24 h after irradiation with 0 or 5 Gy ( xref )."
32390841
BST2 affects ITGB3
| 1
BST2 activates ITGB3. 1 / 1
| 1
sparser
"As platelet granule secretion induced by agonist stimulation plays critical roles in the amplification of platelet signaling and subsequent activation and aggregation, we also measured platelet degranulation, represented by P-selectin expression and αIIbβ3 activation by flow cytometry."
29794149
BST2 affects ANTXR1
| 1
BST2 binds ANTXR1. 1 / 1
| 1
sparser
"Using this strategy, a monoclonal antibody, called AF334, was identified that, like SB5, was able to bind both mouse and human TEM8 by flow cytometry."
21129411
BSG affects F3
| 1
BSG activates F3. 1 / 1
| 1
sparser
"The epithelial CD147 subsequently can activate tissue factor on endothelial cells, a primary step in the coagulation cascade."
30476069
BSG affects ANTXR1
| 1
BSG binds ANTXR1. 1 / 1
| 1
sparser
"In support of this view, Qin et al. (2011) recently showed that the intrinsic resistance of KSHVpositive peripheral effusion lymphomas to the cytotoxic effects of paclitaxel and doxorubicin depends on orchestrated interactions of CD147 with lymphatic vessel endothelial receptor 1 (LYVE-1) and the homodimeric ATP-binding cassette (ABC)-G2/BCRP (breast cancer resistance protein) drug transporter that is highly expressed on the surface of primary effusion lymphoma (PEL)-derived cell lines."
23487416
ATP6AP1 affects GRIA1
| 1
ATP6AP1 phosphorylates GRIA1. 1 / 1
| 1
sparser
"The activation of MSNs in rats was evaluated by measuring glutamate receptor subunit 1 phosphorylation (pGluR1) levels."
| PMC
ATP1A1 affects TRPV4
| 1
ATP1A1 inhibits TRPV4. 1 / 1
| 1
sparser
"Since extracellular NA inhibited TRPV4, we examined the effect of NA on its heat activation."
25752528