INDRA statements for SCN8A

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phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
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MATN3 affects SCN8A
| 25
MATN3 activates SCN8A.
| 24
MATN3 activates SCN8A. 13 / 13
| 13
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"This new observation is of particular interest because mutations in MATN3 cause a MED skeletal phenotype, as well as osteoarthritis of the hand (Briggs and Chapman, 2002; Chapman et al., 2001; Stefansson et al., 2003; Unger and Hecht, 2001)."
15694129
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"Mutations in genes coding cartilage oligomeric matrix protein (COMP), type IX collagen alpha 1, 2, and 3 chains (COL9A1, COL9A2, COL9A3), and matrilin 3 (MATN3) cause the dominantly inherited forms of MED, while homozygous or compound heterozygous mutations in diastrophic dysplasia sulfate transporter (DTDST or SLC26A2) gene cause recessively inherited MED (rMED, EDM4 OMIM 226900)."
20592910
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"Missense mutations in the gene encoding matrilin-3 (MATN3) have been shown to cause some forms of MED and the related disease bilateral heredity micro-ephyseal dysplasia."
19851784
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"Sparing of hip joints, no history of clubfoot or other deformities at birth, and the pattern of inheritance distinguished their conditions from the other MED caused by COMP, MATN3, and DTDST mutations."
25381065
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"Although considerable progress has been made in understanding the disease mechanisms of MED caused by mutations in COMP [XREF_BIBR] and SLC26A2 [XREF_BIBR; XREF_BIBR], virtually nothing is known about the disease mechanisms of MED caused by mutations in MATN3."
16287128
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"MED is genetically heterogeneous and the use of similar mapping approaches has determined that mutations in the genes encoding type IX collagen and matrilin-3 also cause autosomal dominant forms of MED."
19851784
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"Missense mutations in the gene encoding matrilin-3 cause an autosomal dominant form of MED and in total eleven different mutations have now been identified in 26 unrelated families with various forms of MED (see XREF_TABLE)."
16287128
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"The purpose of this study was to compare orthopaedic manifestations of MED caused by MATN3 versus COMP mutations and to subsequently delineate the implication of genotypes in MED."
24629099
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"The phenotype severity of the reported family seems milder than MED caused by MATN3, COMP, and DTDST mutations, and more severe than in patients with mutations in genes encoding collagen type IX."
30740902
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"Mutations in the COMP, COL9A1, COL9A2, COL9A3, MATN3 and SLC26A2 genes cause approximately 70% of multiple epiphyseal dysplasia (MED) cases."
30740902
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"Mutations in the matrilin-3 gene (MATN3) have recently been shown to underlie some forms of autosomal dominant MED."
16287128
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"In this study, the authors compared clinical manifestation of MED patients caused by MATN3 and COMP gene mutations, as well as subsequent orthopaedic interventions."
24629099
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"Clinical manifestations of MED caused by MATN3 were milder than manifestations of the COMP mutation group."
24629099
Mutated MATN3 activates SCN8A. 7 / 7
| 7
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"The aim of this study therefore was to determine the molecular cell pathology of MED caused by MATN3 mutations."
16287128
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"In summary, MED is caused by a defect in the trafficking and secretion of mutant matrilin-3 that causes ER stress and a UPR in the post-natal period."
20428984
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"In summary, the data presented in this paper suggest that MED caused by MATN3 mutations is the result of an intracellular retention of the mutant protein."
16287128
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"This is a similar finding to that seen in MED caused by MATN3 mutations [Jackson et al., XREF_BIBR; Makitie et al., XREF_BIBR] and it is interesting to speculate that the genetic modifiers of phenotypic severity may be common across the spectrum of the pseudoachondroplasia MED (PSACH MED) bone dysplasia family, regardless of which gene the causative mutation resides in."
20358595
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"Previous studies have shown that the mechanism leading to MED caused by matrilin-3 mutations involves the induction of a UPR and dysregulated apoptosis."
24046357
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"Similar to MCDS, those forms of MED caused by MATN3 mutations (MATN3 MED) have ER stress and classic UPR as a core disease mechanism 19; however, unlike MCDS, cell and mouse models of MATN3 MED do not respond to CBZ treatment (unpublished data)."
32399188
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"Therefore, the molecular cell pathology of MED caused by MATN3 mutations has similarities to skeletal dysplasias caused by mutations in the genes encoding other extracellular matrix structural proteins, particularly PSACH and forms of MED that result from mutations in COMP [XREF_BIBR]."
16287128
MATN3-V194D activates SCN8A. 4 / 4
| 4
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"We previously showed that reduced chondrocyte proliferation in the growth plate was a key disease mechanism in a murine model of MED caused by a Matn3 V194D mutation."
22083516
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"Although intracellular retention of the majority of mutant matrilin 3 was previously observed in a murine model of MED caused by a Matn3 V194D mutation, some mutant protein was secreted into the extracellular matrix."
22083516
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"This distinctive finding was recently verified in a murine model of MED caused by a Matn3 V194D mutation, which replicated the human phenotype by exhibiting mild short limbed dwarfism."
22083516
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"Armet and Creld2 are up-regulated in cell and murine models of MED caused by matrilin-3 V194D."
23956175
MATN3 binds SCN8A.
| 1
SCN8A binds MATN3. 1 / 1
| 1
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"To better understand the function of MATN3 during chondrogenesis, we stably transfected the ATDC5 murine chondroprogenitor cell line with a WT MATN3 gene construct or constructs carrying the MATN3 point mutations associated with either MED or SEMD, respectively (XREF_FIG)."
25196597
COMP affects SCN8A
| 19
COMP activates SCN8A.
| 18
COMP activates SCN8A. 12 / 12
| 12
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"The advent of molecular genetics has validated their original hypothesis, and we now suggest that abnormalities in COMP primarily produce severe forms of MED (MED type I), whereas certain mutations in the COL9A2 gene produce milder forms of the disease (MED type II)."
10364514
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"Mutations in the COMP, COL9A1, COL9A2, COL9A3, MATN3 and SLC26A2 genes cause approximately 70% of multiple epiphyseal dysplasia (MED) cases."
30740902
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"Interest in this extracellular matrix protein increased when it was recognized that mutations in COMP caused pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED and EDM1) XREF_BIBR, XREF_BIBR."
20421976
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"Interestingly, some autosomal dominant osteochondrodysplasias (PSACH and some MED) are caused by mutations in COMP that interfere with normal extracellular matrix assembly, which is thought to contribute to the development of the patient phenotypes."
19035482
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"In this study, we showed that mutations in Comp that cause PSACH MED result in altered collagen fibril diameters in force loaded tendons and ligaments and is associated with a mild muscle myopathy in the absence of a detectable muscle pathology."
19808781
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"So far, mutations in COMP and COL9A2 have been shown to cause MED phenotype."
10090888
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"Mutations in the COMP gene and in two genes (COL9A2; COL9A3), coding respectively for the alpha2 (IX) and alpha3 (IX) chains of type IX collagen, can cause the autosomal dominant forms of MED."
11528506
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"Although considerable progress has been made in understanding the disease mechanisms of MED caused by mutations in COMP [XREF_BIBR] and SLC26A2 [XREF_BIBR; XREF_BIBR], virtually nothing is known about the disease mechanisms of MED caused by mutations in MATN3."
16287128
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"The phenotype severity of the reported family seems milder than MED caused by MATN3, COMP, and DTDST mutations, and more severe than in patients with mutations in genes encoding collagen type IX."
30740902
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"Sparing of hip joints, no history of clubfoot or other deformities at birth, and the pattern of inheritance distinguished their conditions from the other MED caused by COMP, MATN3, and DTDST mutations."
25381065
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"In this study, the authors compared clinical manifestation of MED patients caused by MATN3 and COMP gene mutations, as well as subsequent orthopaedic interventions."
24629099
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"Such mechanism is similar to that of a point mutation of cartilage oligomeric matrix protein (COMP), which also leads to MED or related pseudoachondroplasia [XREF_BIBR]."
18518980
Mutated COMP activates SCN8A. 6 / 6
| 6
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"Such mechanism is similar to that of a point mutation of cartilage oligomeric matrix protein (COMP), which also leads to MED or related pseudoachondroplasia [XREF_BIBR]."
18518980
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"Interestingly, the other common CTD COMP mutation at residue 585 (c. 1754C> T p. (Thr585Met); c. 1754C> G p. (Thr585Arg) and c. 1754C> A p. (Thr585Lys); n = 6; ~ 21%) often causes a transitional phenotype of mild PSACH to severe MED 9 and the association of mild myopathy with CTD COMP mutations is well documented."
24595329
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"Both of these factors have been shown to be activated in a mouse model of PSACH MED caused by a Comp mutation and the former in a mouse model of MCDS caused by a mutation in col10a1."
20428984
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"We reviewed radiographs from two patients with MED produced by COMP mutations, two families with COL9A2 mutations, and one family with a mutation in COL9A3."
11200990
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"The majority (> 85%) of COMP mutations causing PSACH or MED are found in the exons encoding the T3 repeats, and the disease mechanism has been characterised in detail."
15880723
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"14 In conclusion, we have collated 300 COMP mutations that cause PSACH and MED and have derived the first genotype to phenotype correlations."
24595329
COMP inhibits SCN8A.
| 1
COMP inhibits SCN8A. 1 / 1
| 1
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"Therefore, long-term knock down of COMP is necessary to suppress PSACH and MED and EDM1 cellular phenotype."
20421976
COL9A2 affects SCN8A
| 12
COL9A2 activates SCN8A. 9 / 9
| 9
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"So far, mutations in COMP and COL9A2 have been shown to cause MED phenotype."
10090888
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"Muragaki et al. (1996) and van Mourik et al. (1998) reported that a splice site mutation in COL9A2 has been shown to cause MED of an unclassified form in one family."
10090888
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"Because COL9A2 and COL9A3 mutations can cause MED, one could expect COL9A1 to be another locus for MED."
10090888
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"Because of the recent discovery that a mutation in the intron 3 splice-donor site of COL9A2 produces the Fairbank type of MED (Muragaki et al. 1996), we have screened affected individuals from 28 unrelated families with various types of MED, for mutations in the exon 9/intron 9 splice-donor site of COL9A1 and in the exon 3/intron 3 splice-donor sites of COL9A2 and COL9A3."
10364514
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"Mutations in the COMP gene and in two genes (COL9A2; COL9A3), coding respectively for the alpha2 (IX) and alpha3 (IX) chains of type IX collagen, can cause the autosomal dominant forms of MED."
11528506
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"On the other hand, this is not an exclusive feature of DTDST defect considering that XREF_BIBR observed it in a 12-year-old boy with an autosomal dominant form of MED caused by mutation in the COL9A2 gene."
30740902
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"Mutations in the COMP, COL9A1, COL9A2, COL9A3, MATN3 and SLC26A2 genes cause approximately 70% of multiple epiphyseal dysplasia (MED) cases."
30740902
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"One of the affected family members had a double layered patella, which is frequently seen in patients with autosomal recessive MED caused by DTDST mutations and sporadically in the dominant form of MED caused by COL9A2 defect."
30740902
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"The phenotype caused by the COL9A3 mutation is similar to that caused by the mutation in the COL9A2 gene, thus emphasizing the potential role of the COL3 domain in the pathogenesis of MED."
10090888
Mutated COL9A2 activates SCN8A. 3 / 3
| 3
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"Clinical, radiographic, and questionnaire data from affected family members suggested that MED caused by COL9A2 mutations starts in early childhood with knee pain accompanied by delayed ossification of femoral epiphyses."
19995321
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"Our findings show that MED caused by this particular COL9A2 mutation generally starts in early childhood with knee pain, which is accompanied by delayed ossification of femoral epiphyses."
19995321
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"Furthermore, like COL9A3 mutations, myopathy is not a consistent feature of MED caused by COL9A2 mutations."
20358595
SCN8A affects MATN3
| 11
SCN8A activates MATN3.
| 8
SCN8A activates MATN3. 6 / 6
| 6
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"Mice expressing the MED causing Matn3 p.V194D mutation demonstrated a high level of mutant matrilin-3 retention."
25693198
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"All of the MED causing mutations in MATN3 are found in the single A-domain of matrilin-3 in either the beta-strand or alpha-helix regions."
20428984
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"To date, all MED causing mutations in matrilin-3 are located within the single A-domain and primarily affect residues that comprise the central beta-sheet."
23956175
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"Interesting, all of MED causing mutations in MATN3 are found in the single A-domain of matrilin-3 in either the beta-strand or alpha-helix regions."
19851784
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"3 In contrast, autosomal dominant MED is genetically heterogeneous and although in the European population the largest proportion results from COMP mutations, other forms of MED can be caused by mutations in the genes encoding matrilin-3 (MATN3) and type IX collagen (COL9A1, COL9A2 and COL9A3)."
24595329
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"In contrast, COMP-null mice show no differences in collagen fibril diameter and these data therefore suggest that PSACH and MED causing mutations in matrilin-3 and COMP can cause changes in the ultra-structure of the cartilage ECM through antimorphic mechanisms."
23951406
SCN8A activates mutated MATN3. 2 / 2
| 2
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"In this study, we explored the effect of Matn1 deletion on the phenotype of mice that were homozygous for a MED causing matrilin 3 mutation (Matn3 V194D)."
22083516
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"In conclusion, we explored the effect of matrilin 1 deletion in mice homozygous for a MED causing matrilin 3 mutation."
22083516
SCN8A inhibits MATN3.
| 2
Mutated SCN8A inhibits MATN3. 1 / 1
| 1
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"MED Mutations Disrupt the Folding of the Matrilin-3 A-Domain."
16287128
SCN8A inhibits MATN3. 1 / 1
| 1
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"WT MATN3 Induces Spontaneous Chondrogenesis, while MED and SEMD Mutations Diminish MATN3 Induced Chondrogenic Effects, in Chondroprogenitors."
25196597
SCN8A binds MATN3.
| 1
SCN8A binds MATN3. 1 / 1
| 1
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"To better understand the function of MATN3 during chondrogenesis, we stably transfected the ATDC5 murine chondroprogenitor cell line with a WT MATN3 gene construct or constructs carrying the MATN3 point mutations associated with either MED or SEMD, respectively (XREF_FIG)."
25196597
SCN8A affects TRAF6
| 9
SCN8A deubiquitinates TRAF6.
| 7
SCN8A leads to the deubiquitination of TRAF6. 7 / 7
| 7
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"To determine whether MED can inhibit the ubiquitination of TRAF6 independently on TLR4 signaling, we performed the ubiquitination assays in 293T cells without LPS treatment."
22984582
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"MED suppressed the polyubiquitination of TRAF6, but did not affect TRAF6 dimerization and IRAK1 phosphorylation, suggesting that TRAF6 could be the target of MED in response to LPS."
22984582
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"MED significantly inhibited TAK1 phosphorylation and TRAF6 polyubiquitination, but not IRAK1 phosphorylation and TRAF6 dimerization, indicating that MED inhibits LPS induced inflammatory responses at least in part through suppression of TRAF6 polyubiquitination."
22984582
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"Indeed, we found that MED significantly blocked the ubiquitination of TRAF6 and IkappaBalpha (XREF_FIG and XREF_SUPPLEMENTARY) in HEK 293T cells without LPS treatment, indicating that MED can inhibit protein ubiquitination independently on TLR4 signaling."
22984582
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"Furthermore, MED also markedly suppressed the ubiquitination of TRAF6 in vitro ubiquitination system (XREF_FIG)."
22984582
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"As shown in XREF_FIG, MED blocked the ubiquitination of TRAF6 in a dose dependent manner."
22984582
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"MED inhibited not only polyubiquitination of TRAF6 but also polyubiquitination mediated degradation of IRAK1 and IkappaBalpha induced by LPS, implicating that MED may serve as an ubiquitination inhibitor to inhibit the ubiquitination of proteins involved in TLR4 pathway."
22984582
SCN8A inhibits TRAF6.
| 1
SCN8A inhibits TRAF6. 1 / 1
| 1
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"In addition, we investigated whether MED could block dimerization of TRAF6 in HEK 293T cells overexpressing TRAF6."
22984582
SCN8A dephosphorylates TRAF6.
| 1
SCN8A leads to the dephosphorylation of TRAF6. 1 / 1
| 1
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"MED significantly inhibited TAK1 phosphorylation and TRAF6 polyubiquitination, but not IRAK1 phosphorylation and TRAF6 dimerization, indicating that MED inhibits LPS induced inflammatory responses at least in part through suppression of TRAF6 polyubiquitination."
22984582
Enalapril affects SCN8A
| 8
Enalapril inhibits SCN8A.
| 7
Enalapril inhibits SCN8A. 7 / 7
| 7
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"Enalapril Inhibits MED Induced Increase of SBP."
26640794
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"Enalapril markedly inhibited MED induced increase of TBARS level."
26640794
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"In addition, the treatment of enalapril significantly inhibited MED resulting ER stress in aortae of rats."
26640794
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"Enalapril Inhibits MED Induced Oxidative Stress in Rats."
26640794
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"Enalapril Inhibits MED Resulting Increase of Ang II Induced Contractile Response."
26640794
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"The results indicated that MED resulted in hypertension and enalapril could suppress MED induced hypertension in rats."
26640794
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"The results showed that enalapril significantly inhibited MED induced increase of SBP and Ang II induced contractile response in aortae of rats."
26640794
Enalapril activates SCN8A.
| 1
Enalapril activates SCN8A. 1 / 1
| 1
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"In the MED + enalapril group, rats were treated with enalapril (15mg/kg/day)."
26640794
SLC26A2 affects SCN8A
| 8
Mutated SLC26A2 activates SCN8A. 4 / 4
| 4
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"Sparing of hip joints, no history of clubfoot or other deformities at birth, and the pattern of inheritance distinguished their conditions from the other MED caused by COMP, MATN3, and DTDST mutations."
25381065
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"The phenotype severity of the reported family seems milder than MED caused by MATN3, COMP, and DTDST mutations, and more severe than in patients with mutations in genes encoding collagen type IX."
30740902
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"Double layered patella and hip dysplasia are the most common radiographic findings in a recessive form of MED caused by DTDST mutations."
30740902
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"One of the affected family members had a double layered patella, which is frequently seen in patients with autosomal recessive MED caused by DTDST mutations and sporadically in the dominant form of MED caused by COL9A2 defect."
30740902
SLC26A2 activates SCN8A. 4 / 4
| 4
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"Although considerable progress has been made in understanding the disease mechanisms of MED caused by mutations in COMP [XREF_BIBR] and SLC26A2 [XREF_BIBR; XREF_BIBR], virtually nothing is known about the disease mechanisms of MED caused by mutations in MATN3."
16287128
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"The homozygous A2092T (T689S) mutation could be one of the mutations in the DTDST gene causing MED."
23934641
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"Mutations in the COMP, COL9A1, COL9A2, COL9A3, MATN3 and SLC26A2 genes cause approximately 70% of multiple epiphyseal dysplasia (MED) cases."
30740902
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"EDM4 contains the DTDST gene, in which a homozygous R279W mutation was shown to cause recessively inherited MED associated with club foot and double layered patella (Superti-Furga et al. 1999)."
11565064
SCN8A affects sodium(1+)
1 | 6
SCN8A activates sodium(1+).
| 4
SCN8A activates sodium(1+). 4 / 4
| 4
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"Based on analysis of cells from mice with a Scn8a null mutation, Scn8a channels appear to contribute significantly to total sodium current in both in P10-P14 Purkinje cells (approximately 40%; [21]) and cultured P7-P8 spinal motoneurons (approximately 70% [K.D. Garcia, L.K. Sprunger, M.H. Meisler, K.G. Beam, The sodium channel Scn8a is the major contributor to the postnatal developmental increase of sodium current density in spinal motoneurons, J. Neurosci."
10592298
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"SCN8A encephalopathy is a newly defined EE caused by de novo mutations of the gene SCN8A encoding the sodium channel Na v 1.6 (OMIM # 614558)."
27270488
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"Functional studies suggest that SCN8A missense mutations may cause impaired channel inactivation and persistent sodium current, which may increase neuronal excitability and firing."
28775708
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"Three recognized sodium channel gene EEs are caused by mutations in SCN8A, SCN1A (Dravet syndrome), SCN2A, and SCN8A."
27270488
SCN8A inhibits sodium(1+).
| 2
SCN8A inhibits sodium(1+). 2 / 2
| 2
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"However, the available mouse models of Scn8a dysfunction have reduced sodium currents, whereas the N1786D is a gain-of-function mutation with increased persistent current, and Celf4 deficiency is believed to result in increased Na v 1.6 expression at the axon initial segment and increased persistent current."
24704313
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"Lower levels of SCN1A, SCN2A, SCN3A, SCN4A and SCN8A expression have also been reported in heart and shown to contribute approximately 23% of the total functional sodium channels in mouse ventricular myocytes and 27% in human atrial myocytes, based on TTX sensitivity."
27702655
SCN8A increases the amount of sodium(1+).
1 |
SCN8A increases the amount of sodium(1+). 1 / 1
1 |
signor
"Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential."
27262167
SCN8A affects DNA Damage
| 7
SCN8A activates DNA Damage. 7 / 7
| 7
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"MED induced DNA damage through the production of reactive oxygen species (ROS), which resulted in the phosphorylation of H2A histone family memeber X (H2AX) and the activation of the Ataxia telangiectasia mutated kinase (ATM) and p53 signaling pathways."
24473167
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"Figure 2 (a) shows the epidermal DNA damage induced by single exposures of 0.65 MED or 2 MED SSR in skin types II and IV."
11982760
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"However, DNA damage can be triggered by suberythematous UV exposure [5] and Bruze et al. [6] found that dimer yield was independent of MED."
11684455
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"Indeed the data indicate that the values of the extent of DNA damage induced in volunteers with skin type II and III by 2 MED can be grouped into two well separated populations centered around UDS values 13 and 20."
11684455
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"Figure 2 (b) shows the epidermal DNA damage induced by repeat exposures of 0.65 MED SSR in skin types II and IV when biopsies were taken immediately after the last tanning treatment dose."
11982760
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"One study compared DNA damage induced by a 2 MED SSR challenge after 10 consecutive daily exposure of 0.7 MED SSR with and without a UVB sunscreen containing 30ppm 5-methoxypsoralen (5-MOP) which enhances pigmentation (Young etal., 1991)."
27454804
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"The present results show that MED induces DNA damage through the production of reactive oxygen species (ROS), which resulted in the phosphorylation of H2AX and the activation of the Ataxia telangiectasia mutated kinase (ATM) and p53 signaling pathways."
22796259
SCN8A affects IL6
| 6
SCN8A decreases the amount of IL6.
| 5
SCN8A decreases the amount of IL6. 5 / 5
| 5
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"Furthermore, MED could significantly suppress the mRNA levels of TNF-alpha, IL-1beta and IL-6 induced by LPS (XREF_FIG), indicating that MED inhibits LPS induced cytokine expression at the transcriptional level."
22984582
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"Consistently, MED significantly suppressed the levels of serum IL-1beta and IL-6 (XREF_FIG)."
22984582
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"Herein, we have shown that MED can significantly inhibit the ox-LDL-induced expression of TNF-alpha, IL-6, and IL-1beta both in RAW264.7 cells and in plaque lesion areas, which suggests that MED can suppress inflammatory responses in atherosclerosis."
26045945
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"The MED feeding significantly downregulated the expressions of the p50, p65, TNFalpha, IL-6, IFNalpha, IFNbeta, IL-12-p40, and CXCL2 genes compared to the ED mice (XREF_FIG)."
22013387
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"XREF_FIG, MED suppressed the protein levels of TNF-alpha, IL-6, and IL-1beta in plasma and the mRNA levels of TNF-alpha, IL-6, and IL-1beta in the aortic arch."
26045945
SCN8A inhibits IL6.
| 1
SCN8A inhibits IL6. 1 / 1
| 1
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"XREF_FIG, MED significantly inhibited the ox-LDL-induced production of TNF-alpha, IL-6, and IL-1beta."
26045945
SCN8A affects IL1B
| 6
SCN8A decreases the amount of IL1B.
| 4
SCN8A decreases the amount of IL1B. 4 / 4
| 4
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"Furthermore, MED could significantly suppress the mRNA levels of TNF-alpha, IL-1beta and IL-6 induced by LPS (XREF_FIG), indicating that MED inhibits LPS induced cytokine expression at the transcriptional level."
22984582
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"Consistently, MED significantly suppressed the levels of serum IL-1beta and IL-6 (XREF_FIG)."
22984582
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"Herein, we have shown that MED can significantly inhibit the ox-LDL-induced expression of TNF-alpha, IL-6, and IL-1beta both in RAW264.7 cells and in plaque lesion areas, which suggests that MED can suppress inflammatory responses in atherosclerosis."
26045945
reach
"XREF_FIG, MED suppressed the protein levels of TNF-alpha, IL-6, and IL-1beta in plasma and the mRNA levels of TNF-alpha, IL-6, and IL-1beta in the aortic arch."
26045945
SCN8A inhibits IL1B.
| 1
SCN8A inhibits IL1B. 1 / 1
| 1
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"XREF_FIG, MED significantly inhibited the ox-LDL-induced production of TNF-alpha, IL-6, and IL-1beta."
26045945
SCN8A increases the amount of IL1B.
| 1
SCN8A increases the amount of IL1B. 1 / 1
| 1
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"On the contrary, a single MED significantly enhanced mRNA levels of interleukin-1alpha (IL-1alpha), IL-1beta (P < 0.02) and plasminogen activator inhibitor-1 (P < 0.05)."
15115299
SCN8A affects lipopolysaccharide
| 5
SCN8A inhibits lipopolysaccharide. 5 / 5
| 5
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"MED inhibited LPS induced nuclear translocation of nuclear factor (NF)-kappaB (NF-kappaB) p65, IkappaB degradation, IkappaB kinase (IKK) phosphorylation, and the activation of extracellular signal regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38, suggesting that MED blocks the activation of both NF-kappaB and mitogen activated protein kinase (MAPK) pathways."
22984582
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"Consistently, MED suppressed LPS stimulated iNOS protein production in a dose dependent manner (XREF_FIG)."
22984582
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"The observations that MED effectively inhibited LPS induced inflammatory responses in vitro prompted us to investigate whether MED can inhibit LPS induced endotoxin shock in vivo."
22984582
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"Recently, we have showed that MED could inhibit LPS induced inflammatory responses, ovariectomy induced osteoporosis, and allergic responses in mice [XREF_BIBR - XREF_BIBR]."
26045945
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"MED significantly inhibited LPS induced production of pro inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon-gamma (INF-gamma), and nitric oxide (NO), whereas it increased anti-inflammatory interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1) production in BV2 microglia in a concentration dependent manner without causing cytotoxicity."
24447679
SCN8A affects homocysteine
| 5
SCN8A increases the amount of homocysteine.
| 4
SCN8A increases the amount of homocysteine. 4 / 4
| 4
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"MED significantly increased plasma levels of homocysteine (Hcy) and ACE."
26640794
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"In addition, the treatment of enalapril significantly inhibited the increase of plasma levels of Hcy induced by MED."
26640794
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"In XREF_FIG, we showed that MED increased the plasma levels of Hcy to more than three times that of SD rats."
26640794
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"We found that MED increased Hcy level, activated ACE, and then induced ER stress and oxidative stress, leading to the increase of SBP (XREF_FIG)."
26640794
SCN8A decreases the amount of homocysteine.
| 1
SCN8A decreases the amount of homocysteine. 1 / 1
| 1
reach
"Enalapril Inhibits MED Induced Increase of Plasma Hcy Levels."
26640794
SCN8A affects apoptotic process
| 5
SCN8A activates apoptotic process.
| 4
SCN8A activates apoptotic process. 4 / 4
| 4
reach
"Mycoepoxydiene (MED) can inhibit Hsp90 function and induce apoptosis in cervical cancer cells."
25014191
reach
"Finally, Annexin-PI staining of apoptotic cells revealed that MED inhibition of GRP78 leads to reduced osteoblast apoptosis and increased osteoblast survival."
27316719
reach
"The results demonstrated that MED induced apoptosis in CCA cells such as SK-ChA-1 and Mz-ChA-1 through inhibiting the expression of anti-apoptotic proteins such as Bcl-XL and Bcl-2, two targets of NF-kappaB."
24486723
reach
"Here, we report the molecular mechanisms of apoptosis activation and growth inhibition induced by MED in MCF-7 cells."
22796259
SCN8A inhibits apoptotic process.
| 1
SCN8A inhibits apoptotic process. 1 / 1
| 1
reach
"LoD and MeD selenite significantly reduced the TNFalpha induced GAG release (by 83, 55%, respectively), NO production (by 59, 40%, respectively), and apoptosis (by 68, 39%, respectively)."
27783214
SCN8A affects TNF
| 5
SCN8A decreases the amount of TNF.
| 4
SCN8A decreases the amount of TNF. 4 / 4
| 4
reach
"Herein, we have shown that MED can significantly inhibit the ox-LDL-induced expression of TNF-alpha, IL-6, and IL-1beta both in RAW264.7 cells and in plaque lesion areas, which suggests that MED can suppress inflammatory responses in atherosclerosis."
26045945
reach
"XREF_FIG, MED suppressed the protein levels of TNF-alpha, IL-6, and IL-1beta in plasma and the mRNA levels of TNF-alpha, IL-6, and IL-1beta in the aortic arch."
26045945
reach
"Furthermore, MED could significantly suppress the mRNA levels of TNF-alpha, IL-1beta and IL-6 induced by LPS (XREF_FIG), indicating that MED inhibits LPS induced cytokine expression at the transcriptional level."
22984582
reach
"The MED feeding significantly downregulated the expressions of the p50, p65, TNFalpha, IL-6, IFNalpha, IFNbeta, IL-12-p40, and CXCL2 genes compared to the ED mice (XREF_FIG)."
22013387
SCN8A inhibits TNF.
| 1
SCN8A inhibits TNF. 1 / 1
| 1
reach
"XREF_FIG, MED significantly inhibited the ox-LDL-induced production of TNF-alpha, IL-6, and IL-1beta."
26045945
SCN8A affects SHBG
| 5
SCN8A activates SHBG. 5 / 5
| 5
reach
"Enalapril Inhibits MED Induced Increase of SBP."
26640794
reach
"The results showed that MED induced significant increase of SBP and Ang II induced contractile response in aortae of rats."
26640794
reach
"As shown in XREF_FIG, one-month administration of methionine enriched diet (MED) significantly increased SBP to 158 +/- 11mmHg in rats."
26640794
reach
"The results showed that enalapril significantly inhibited MED induced increase of SBP and Ang II induced contractile response in aortae of rats."
26640794
reach
"Two-month administration of MED significantly increased SBP to 179 +/- 12mmHg in rats."
26640794
SCN8A affects OLR1
| 5
SCN8A decreases the amount of OLR1.
| 4
SCN8A decreases the amount of OLR1. 4 / 4
| 4
reach
"MED inhibits ox-LDL-induced LOX-1 expression in macrophages."
26045945
reach
"XREF_FIG, MED significantly inhibited the LOX-1 protein levels in a dose dependent manner."
26045945
reach
"XREF_FIG, MED significantly suppressed the mRNA levels of LOX-1, which indicated that MED may inhibit ox-LDL-induced LOX-1 expression at the transcriptional level."
26045945
reach
"In our present study, MED could significantly inhibit RAW 264.7 cells transformation into foam cells and LOX-1 expression induced by ox-LDL, which indicated that the suppression of LOX-1 expression by MED contributes to its inhibitory effects on macrophage foam cell formation."
26045945
SCN8A increases the amount of OLR1.
| 1
SCN8A increases the amount of OLR1. 1 / 1
| 1
reach
"In our present study, MED could significantly inhibit RAW 264.7 cells transformation into foam cells and LOX-1 expression induced by ox-LDL, which indicated that the suppression of LOX-1 expression by MED contributes to its inhibitory effects on macrophage foam cell formation."
26045945
SCN8A affects NFkappaB
| 5
SCN8A inhibits NFkappaB.
| 4
SCN8A inhibits NFkappaB. 4 / 4
| 4
reach
"To explore whether MED could inhibit NF-kappaB signaling, the effects of MED on ox-LDL-induced NF-kappaB activation in RAW 264.7 cells were examined."
26045945
reach
"In this study, we showed that MED could inhibit receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation and the expression of three well-known osteoclast markers such as tartrate resistant acid phosphatase, calcitonin receptor, and cathepsin K in bone marrow derived macrophages."
22678021
reach
"MED inhibits ox-LDL induced activation of NF-kappaB signaling in macrophages."
26045945
reach
"MED inhibited LPS induced nuclear translocation of nuclear factor (NF)-kappaB (NF-kappaB) p65, IkappaB degradation, IkappaB kinase (IKK) phosphorylation, and the activation of extracellular signal regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38, suggesting that MED blocks the activation of both NF-kappaB and mitogen activated protein kinase (MAPK) pathways."
22984582
SCN8A activates NFkappaB.
| 1
SCN8A activates NFkappaB. 1 / 1
| 1
reach
"Therefore, we conclude that MED inhibits MCF-7 cells by simultaneously activating p53 to induce apoptosis and suppressing NF-kappaB to disrupt cell proliferation."
22796259
SCN8A affects MCF2L2
| 5
SCN8A activates MCF2L2.
| 4
SCN8A activates MCF2L2. 4 / 4
| 4
reach
"Moreover, IP and ChIP assays showed that L5-VRT enhanced the interaction between p-STAT3 and p300 and increased the recruitment of p-STAT3 and histone H4 acetylation on the Scn8a promoter in DRG."
30736806
reach
"TNF-alpha promotes the combination of p-STAT3 and p300 and Scn8a promoter in DRG."
30736806
reach
"Furthermore, immunoprecipitation and chromatin immunoprecipitation assays demonstrated that L5-VRT increased the binding of STAT3 to the Scn8a (encoding Nav1.6) promoter and the interaction between STAT3 and p300, which contributed to the enhanced transcription of Scn8a by increasing histone H4 acetylation in Scn8a promoter in DRG."
30736806
reach
"Here, to determine whether the activated STAT3 signaling transcriptionally regulated the expression of Nav1.6, we first observed the binding of STAT3 in the Scn8a promoter in DRG using a ChIP-PCR assay."
30736806
SCN8A inhibits MCF2L2.
| 1
SCN8A inhibits MCF2L2. 1 / 1
| 1
reach
"The average TTX-S current density was reduced by 47% in Scn8a medtg large DRG neurons that express TTX-R sodium currents (WT : 701 +/-98 pA/pF, n = 6; MED, 374 +/-80 pA/pF, n = 4; p = 0.045)."
29497094
SCN8A affects CRSP
| 5
CRSP binds SCN8A. 5 / 5
| 5
reach
"Although these observations suggest that the CRSP and MED complex may also be altered or possibly discarded in differentiated myotubes, more work is required to dissect the fate of CRSP and MED."
18851836
reach
"To directly test the requirement for CRSP and MED complex in our reconstituted transcription reactions, we have incubated our Myogenin template with TAF3 and TRF3, MyoD and E47 and CRSP and MED complex."
18851836
reach
"This intriguing finding raises the possibility that the canonical CRSP and MED complex may also be dramatically altered and possibly disposable during terminal differentiation."
18851836
reach
"It has been well established that in addition to TFIID, the multi and subunit complex CRSP and MED can function to mediate activator dependent transcription."
18851836
reach
"Interestingly, MED1 expression was only detected in fibroblasts while none of the C2C12 derived skeletal muscle cell types expressed detectable levels of this largest subunit of the CRSP and MED complex (XREF_FIG)."
18851836
FGF14 affects SCN8A
2 3 |
FGF14 binds SCN8A.
1 3 |
SCN8A binds FGF14. 4 / 4
1 3 |
biogrid
No evidence text available
25659151
biogrid
No evidence text available
25659151
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
biogrid
No evidence text available
25659151
FGF14 inhibits SCN8A.
1 |
FGF14 inhibits SCN8A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
CRSP affects SCN8A
| 5
CRSP binds SCN8A. 5 / 5
| 5
reach
"Although these observations suggest that the CRSP and MED complex may also be altered or possibly discarded in differentiated myotubes, more work is required to dissect the fate of CRSP and MED."
18851836
reach
"To directly test the requirement for CRSP and MED complex in our reconstituted transcription reactions, we have incubated our Myogenin template with TAF3 and TRF3, MyoD and E47 and CRSP and MED complex."
18851836
reach
"This intriguing finding raises the possibility that the canonical CRSP and MED complex may also be dramatically altered and possibly disposable during terminal differentiation."
18851836
reach
"It has been well established that in addition to TFIID, the multi and subunit complex CRSP and MED can function to mediate activator dependent transcription."
18851836
reach
"Interestingly, MED1 expression was only detected in fibroblasts while none of the C2C12 derived skeletal muscle cell types expressed detectable levels of this largest subunit of the CRSP and MED complex (XREF_FIG)."
18851836
COL9A3 affects SCN8A
| 5
Mutated COL9A3 activates SCN8A. 3 / 3
| 3
reach
"Because COL9A2 and COL9A3 mutations can cause MED, one could expect COL9A1 to be another locus for MED."
10090888
reach
"However, we have a reservation with this opinion, because symptoms of MED caused by COL9A3 mutations are mild and the patients with microdeletion at 20q13.33 had combined abnormalities in morphology and psychomotor and behavioral development."
25381065
reach
"However, myopathy does not appear to be a consistent feature of MED caused by COL9A3 mutations [Paassilta et al., XREF_BIBR; Nakashima et al., XREF_BIBR] and it has been suggested that the degree of muscle weakness correlates with the severity of the MED phenotype [Nakashima et al., XREF_BIBR]."
20358595
COL9A3 activates SCN8A. 2 / 2
| 2
reach
"Mutations in the COMP, COL9A1, COL9A2, COL9A3, MATN3 and SLC26A2 genes cause approximately 70% of multiple epiphyseal dysplasia (MED) cases."
30740902
reach
"Mutations in genes coding cartilage oligomeric matrix protein (COMP), type IX collagen alpha 1, 2, and 3 chains (COL9A1, COL9A2, COL9A3), and matrilin 3 (MATN3) cause the dominantly inherited forms of MED, while homozygous or compound heterozygous mutations in diastrophic dysplasia sulfate transporter (DTDST or SLC26A2) gene cause recessively inherited MED (rMED, EDM4 OMIM 226900)."
20592910
CDYL affects SCN8A
| 5
CDYL decreases the amount of SCN8A.
| 4
CDYL decreases the amount of SCN8A. 4 / 4
| 4
reach
"Having established that CDYL inhibits SCN8A expression transcriptionally, we next examined whether and how CDYL regulates Nav1.6-mediated sodium currents and AP threshold in neuronal cells."
28842554
reach
"These results probably reflect the dose dependent effect in which complete ablation of CDYL in a cell line more dramatically affect regional histone modification as compared to mild overexpression of CDYL in experimental animals, and demonstrate that change of regional H3K27me3 is the major underlying mechanism for CDYL repression of SCN8A expression."
28842554
reach
"Consistent with the above demonstrated role of EZH2 in coordinating with CDYL in regulating SCN8A expression, reducing EZH2 expression in the hippocampus of transgenic mice over-expressing CDYL alleviated CDYL mediated changes of AP threshold, supporting the notion that CDYL coordinates with EZH2 to inhibit SCN8A expression and thus suppress intrinsic neuronal excitability."
28842554
reach
"Together, these results support an argument that CDYL inhibits SCN8A transcription mainly through recruiting H3K27me3 methyltransferase activity, possibly also the HDAC activity albeit to a less degree, to the intronic silencer of the gene."
28842554
CDYL inhibits SCN8A.
| 1
CDYL inhibits SCN8A. 1 / 1
| 1
reach
"We demonstrated that CDYL transcriptionally represses SCN8A, the gene encoding Nav1.6 sodium channels, such that the axonal Nav1.6 currents were reduced."
28842554
STAT3 affects SCN8A
| 2 2
STAT3 binds SCN8A.
| 2 1
SCN8A binds STAT3. 3 / 3
| 2 1
sparser
"The results of qPCR analysis revealed that the binding of STAT3 to the Scn8a promoter was enhanced in DRG on day 5 and day 15 following L5-VRT compared to the sham group, which can be reversed by the STAT3 activity inhibitor S3I-201 in the modeled rats (Fig.  xref a)."
30736806
sparser
"Furthermore, immunoprecipitation and chromatin immunoprecipitation assays demonstrated that L5-VRT increased the binding of STAT3 to the Scn8a (encoding Nav1.6) promoter and the interaction between STAT3 and p300, which contributed to the enhanced transcription of Scn8a by increasing histone H4 acetylation in Scn8a promoter in DRG."
30736806
reach
"The results of qPCR analysis revealed that the binding of STAT3 to the Scn8a promoter was enhanced in DRG on day 5 and day 15 following L5-VRT compared to the sham group, which can be reversed by the STAT3 activity inhibitor S3I-201 in the modeled rats."
30736806
STAT3 increases the amount of SCN8A.
| 1
STAT3 bound to EP300 increases the amount of SCN8A. 1 / 1
| 1
reach
"Furthermore, immunoprecipitation and chromatin immunoprecipitation assays demonstrated that L5-VRT increased the binding of STAT3 to the Scn8a (encoding Nav1.6) promoter and the interaction between STAT3 and p300, which contributed to the enhanced transcription of Scn8a by increasing histone H4 acetylation in Scn8a promoter in DRG."
30736806
SCN8A affects sodium atom
| 4
SCN8A activates sodium atom. 4 / 4
| 4
reach
"Heterozygous D/+ mice were crossed with +/- mice carrying the null allele Scn8a medtg that does not produce Na v 1.6 protein due to an intragenic insertion."
25227913
reach
"Taken together, we hypothesize that mutations in the 5N exon of SCN8A could cause disease by altering the inactivation kinetics of the Na v 1.6 channels expressed in early development, leading to hyperexcitability in neurons expressing those channels."
27875746
reach
"Taken together, we hypothesize that mutations in the 5N exon of SCN8A could cause disease by altering the inactivation kinetics of the Na v 1.6 channels expressed in early development, leading to hyperexcitability in neurons expressing those channels.Thus far, there have been no reports of pathogenic variants in the SCN8A 5A exon."
27875746
reach
"SCN8A encephalopathy is a newly defined EE caused by de novo mutations of the gene SCN8A encoding the sodium channel Na v 1.6 (OMIM # 614558)."
27270488
SCN8A affects INS
| 4
SCN8A inhibits INS.
| 3
SCN8A inhibits INS. 3 / 3
| 3
reach
"In subjects with metabolic syndrome, the combination of MeD with moderate-to-high intensity training induces greater improvement in health related quality of life with a greater effect on physical and functional fitness, body weight, enhanced EPCs, and decreased insulin sensitivity, triacylglycerols, and blood pressure than diet alone [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
26783955
reach
"These results indicate that DEX and MED inhibit insulin secretion through an alpha2-adrenoceptor and PTX sensitive GTP binding protein pathway that eventually involves Kv channel activation and Ca2+ channel inhibition."
23171706
reach
"However, when tolbutamide, a specific blocker of the ATP sensitive K+ channel (KATP channel), was present, the magnitude of MED inhibition of insulin secretion was not influenced, suggesting that Kv-channel activity alteration, but not that of KATP channels, is involved in MED associated insulin secretory inhibition."
23171706
SCN8A activates INS.
| 1
SCN8A activates INS. 1 / 1
| 1
reach
"An analysis of the Sicilian diet of centenarians from the Sicani Mountains and the eating habits of the inhabitants of Palermo showed that the low animal protein content and low glycemic index of the Sicilian MeD might directly modulate the insulin and IGF -1 and the mTOR pathways, which might be key pathways by which MeD exerts its beneficial effects in aging and longevity [XREF_BIBR]."
26783955
SCN8A affects FGF14
1 3 |
SCN8A binds FGF14. 4 / 4
1 3 |
biogrid
No evidence text available
25659151
biogrid
No evidence text available
25659151
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
biogrid
No evidence text available
25659151
SCN8A affects ACE
| 4
SCN8A increases the amount of ACE.
| 3
SCN8A increases the amount of ACE. 3 / 3
| 3
reach
"Moreover, the administration of enalapril significantly inhibited the increase of plasma levels of ACE induced by MED."
26640794
reach
"MED significantly increased plasma levels of homocysteine (Hcy) and ACE."
26640794
reach
"As reflected in XREF_FIG, MED significantly increased plasma levels of ACE to three times that of SD rats."
26640794
SCN8A decreases the amount of ACE.
| 1
SCN8A decreases the amount of ACE. 1 / 1
| 1
reach
"Enalapril Inhibits MED Induced Increase of Plasma ACE Levels."
26640794
Collagen affects SCN8A
| 4
Collagen activates SCN8A. 3 / 3
| 3
reach
"CAIA : collagen II antibody induced arthritis; CIA : collagen induced arthritis; CII : collagen II; COMP : cartilage oligomeric matrix protein; ELISA : enzyme linked immunosorbent assay; LPS : lipopolysaccharide; MED : multiple epiphyseal dysplasia; MHC : major histocompatibility complex; PBS : phosphate buffered saline; PCR : polymerase chain reaction; PSACH : pseudoachondroplasia; RA : rheumatoid arthritis; TSP : thrombospondin."
19014566
reach
"These interactions may contribute to the development of the patient phenotypes and may explain why MED can also be caused by mutations in collagen IX genes."
11084047
reach
"Identification of additional mutations, however, is needed to define the full clinical spectrum of MED caused by collagen IX mutations."
10090888
Mutated Collagen activates SCN8A. 1 / 1
| 1
reach
"The ability of the panel to accurately predict a COL9 mutation was a result of the previously documented differences in the clinical and radiographic presentation of MED caused by a type IX collagen mutation compared to COMP and MATN3 mutations [Lachman et al., XREF_BIBR; Unger et al., XREF_BIBR, XREF_BIBR]."
21922596
Salicylic acid affects SCN8A
| 3
Salicylic acid inhibits SCN8A.
| 2
Salicylic acid inhibits SCN8A. 2 / 2
| 2
reach
"The incidence of carcinoma in situ was decreased in male and female mice at 0.3 MED SSL when treated with 4% salicylic acid."
21921960
reach
"Taking into consideration the survival data, time to tumor data, and the pathology results, glycolic acid did not alter the photocarcinogenesis of SSL, and salicylic acid was photoprotective, reducing the carcinogenicity of 0.3 MED SSL."
21921960
Salicylic acid activates SCN8A.
| 1
Salicylic acid activates SCN8A. 1 / 1
| 1
reach
"These showed that MED values were increased by thin or thick petrolatum and also by thin and thick salicylic acid (20%) in petrolatum."
11872412
PolB affects SCN8A
| 3
SCN8A binds polB. 3 / 3
| 3
reach
"Although the mechanism is not fully understood, MED complex tightly binds to Pol II, changes its conformation and affects the transcription initiation process [XREF_BIBR, XREF_BIBR]."
26110885
reach
"The phosphorylation status of Rpb1 CTD heptads is thought to play a critical role in orchestrating the reversible interaction between PolII and MED and this process may be fine tuned by the Cdk8 kinase module."
18515835
reach
"In yeast, the 25 MED subunits are distributed within three core subcomplexes and a separable kinase module composed of Med12, Med13 and the Cdk8-CycC pair thought to control the reversible interaction between MED and PolII by phosphorylating repeated heptapeptides within the Rpb1 carboxyl-terminal domain (CTD)."
18515835
Phorbol 13-acetate 12-myristate affects SCN8A
| 3
Phorbol 13-acetate 12-myristate activates SCN8A. 3 / 3
| 3
reach
"Mitchell et al. [33] reported that mice irradiated with 40 x 0.14 MED and treated with TPA immediately after the last UV exposure already showed an induction of p53 expression and formation of p53 clusters already after 24 h, together with a clear reduction in CRBCs."
17644448
reach
"One week after the last UV irradiation (for the 40 x 0.14 MED group) or the 40-day lag period (for the 1 x 6 MED group) mice dorsa were treated with TPA for maximally 8 weeks to induce epidermal cell proliferation."
17644448
reach
"In contrast to what was found with CM-5 staining, we did not observe any clusters of Pab240 positive cells in mouse epidermis irradiated with 40 x 0.14 MED and treated with TPA for up to 8 weeks (UV induced tumors served as positive controls, while skin with strong wild type p53 expression after 6 MED served as negative control)."
17644448
Gabapentin affects SCN8A
| 3
Gabapentin inhibits SCN8A. 3 / 3
| 3
reach
"Gabapentin reversed mechanical hyperalgesia (MED = 10 mg/kg s.c.), but did not affect thermal hyperalgesia."
12750440
reach
"Gabapentin blocked cold allodynia (MED = 30 mg/kg s.c.), but had marginal effects on mechanical allodynia."
12750440
reach
"In the mouse formalin test, CHF3381 and memantine preferentially inhibited the late phase (MED = 30 and 20 mg/kg i.p., respectively); gabapentin inhibited only the late phase (MED = 30 mg/kg s.c.)."
12750440
TNF affects SCN8A
2 | 1
TNF activates SCN8A.
1 | 1
TNF activates SCN8A. 2 / 2
1 | 1
reach
"TNF-alpha promotes the combination of p-STAT3 and p300 and Scn8a promoter in DRG."
30736806
signor
"TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels."
26112872
TNF increases the amount of SCN8A.
1 |
Transcriptionally active TNF increases the amount of SCN8A. 1 / 1
1 |
signor
"TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels."
26112872
SCNM1 affects SCN8A
| 1 2
SCNM1 activates SCN8A.
| 2
SCNM1 activates SCN8A. 2 / 2
| 2
reach
"SCNM1 enhances non consensus splicing of Scn8a."
27094079
reach
"SCNM1, as well as other splicing regulators such as Rbfox2, can also modulate SCN8A splicing."
26503606
SCNM1 binds SCN8A.
| 1
SCN8A binds SCNM1. 1 / 1
| 1
sparser
"Although the genetic interaction between Scnm1 and Scn8a splicing has been studied in detail, the mechanism of SCNM1 function as a splicing regulator is less clear."
27094079
SCN8A affects polB
| 3
SCN8A binds polB. 3 / 3
| 3
reach
"Although the mechanism is not fully understood, MED complex tightly binds to Pol II, changes its conformation and affects the transcription initiation process [XREF_BIBR, XREF_BIBR]."
26110885
reach
"The phosphorylation status of Rpb1 CTD heptads is thought to play a critical role in orchestrating the reversible interaction between PolII and MED and this process may be fine tuned by the Cdk8 kinase module."
18515835
reach
"In yeast, the 25 MED subunits are distributed within three core subcomplexes and a separable kinase module composed of Med12, Med13 and the Cdk8-CycC pair thought to control the reversible interaction between MED and PolII by phosphorylating repeated heptapeptides within the Rpb1 carboxyl-terminal domain (CTD)."
18515835
SCN8A affects endoplasmic reticulum
| 3
SCN8A activates endoplasmic reticulum. 3 / 3
| 3
reach
"The results showed that methionine enriched diet (MED) induced significant hypertension, ER stress, and oxidative stress in rats."
26640794
reach
"Enalapril Inhibits MED Induced ER Stress in Aortae of Rats."
26640794
reach
"In combination with previous results, the data demonstrated that activation of ACE was involved in MED induced ER stress in aortae of rats."
26640794
SCN8A affects cell death
| 3
SCN8A activates cell death. 3 / 3
| 3
reach
"A high daily MED of prescribed opioid analgesics has been demonstrated to increase the risk of death from drug overdose in diverse populations."
25486625
reach
"Anti-IgM treatment of sIgM (MED) cells induced dose independent death with a 32-h lag."
14565869
reach
"MED induces cell death as a result of the destabilization of Akt and IKK, which may promote cell death through a reduction in the activation of Bad and nuclear factor-kappaB."
25014191
SCN8A affects TP53
| 3
SCN8A phosphorylates TP53.
| 1
SCN8A phosphorylates TP53. 1 / 1
| 1
reach
"We previously reported that in human sun protected skin, 4 MED of UV resulted in the phosphorylation of MAPKAPK2, CREB, c-JUN, p38, GSK-3b and p53 leading to markedly increased levels of c-FOS, COX-2 and apoptosis in the epidermal cells."
26031292
SCN8A inhibits TP53.
| 1
SCN8A inhibits TP53. 1 / 1
| 1
reach
"Therefore, we conclude that MED inhibits MCF-7 cells by simultaneously activating p53 to induce apoptosis and suppressing NF-kappaB to disrupt cell proliferation."
22796259
SCN8A activates TP53.
| 1
SCN8A activates mutated TP53. 1 / 1
| 1
reach
"On histological and immunohistochemical examination, skin treated with GSPE before UV radiation showed fewer sunburn cells and mutant p53 positive epidermal cells and more Langerhans cells compared with skin treated with 2 MED UV radiation only (p < 0.001, p < 0.001, and p < 0.01, respectively)."
22103910
SCN8A affects STAT3
| 2 1
SCN8A binds STAT3. 3 / 3
| 2 1
sparser
"The results of qPCR analysis revealed that the binding of STAT3 to the Scn8a promoter was enhanced in DRG on day 5 and day 15 following L5-VRT compared to the sham group, which can be reversed by the STAT3 activity inhibitor S3I-201 in the modeled rats (Fig.  xref a)."
30736806
sparser
"Furthermore, immunoprecipitation and chromatin immunoprecipitation assays demonstrated that L5-VRT increased the binding of STAT3 to the Scn8a (encoding Nav1.6) promoter and the interaction between STAT3 and p300, which contributed to the enhanced transcription of Scn8a by increasing histone H4 acetylation in Scn8a promoter in DRG."
30736806
reach
"The results of qPCR analysis revealed that the binding of STAT3 to the Scn8a promoter was enhanced in DRG on day 5 and day 15 following L5-VRT compared to the sham group, which can be reversed by the STAT3 activity inhibitor S3I-201 in the modeled rats."
30736806
SCN8A affects RELA
| 3
SCN8A decreases the amount of RELA. 3 / 3
| 3
reach
"Furthermore, MED suppressed nuclear p65 expression in the aortic arch of HFD fed ApoE deficient mice (Additional file 2 : Figure XREF_FIG)."
26045945
reach
"XREF_FIG, MED significantly suppressed ox-LDL-induced IkappaB-alpha degradation, nuclear p65 expression, and the DNA binding activity of NF-kappaB at concentrations of 5 and 10muM in macrophages, which indicated that MED could inhibit the activation of NF-kappaB signaling."
26045945
reach
"The MED feeding significantly downregulated the expressions of the p50, p65, TNFalpha, IL-6, IFNalpha, IFNbeta, IL-12-p40, and CXCL2 genes compared to the ED mice (XREF_FIG)."
22013387
SCN8A affects Psi
| 3
SCN8A activates Psi.
| 2
SCN8A activates Psi. 2 / 2
| 2
reach
"Co-knockdown of CDK8 or CycC suppressed the bending of the Psi adult wings and significantly increased compartment size, consistent with the large MED module normally inhibiting Psi dependent growth."
27207882
reach
"Given the observation that Psi dependent growth was modulated by MED and dMYC, we hypothesised that dMYC dependent growth might be sensitive to MED activity and abundance."
27207882
SCN8A binds Psi.
| 1
SCN8A binds Psi. 1 / 1
| 1
reach
"To determine the importance of the Psi MED interaction to development, we tested whether either transcriptional core or kinase MED subunits were capable of modifying the Psi ' wings up ' phenotype."
27207882
SCN8A affects MAP3K7
| 3
SCN8A inhibits MAP3K7.
| 1
SCN8A inhibits MAP3K7. 1 / 1
| 1
reach
"MED suppressed the activation of TAK1 induced by LPS, indicating that MED negatively affects IKK, p38, and JNK pathways through blocking the activation of TAK1."
22984582
SCN8A deubiquitinates MAP3K7.
| 1
SCN8A leads to the deubiquitination of MAP3K7. 1 / 1
| 1
reach
"MED significantly inhibited TAK1 phosphorylation and TRAF6 polyubiquitination, but not IRAK1 phosphorylation and TRAF6 dimerization, indicating that MED inhibits LPS induced inflammatory responses at least in part through suppression of TRAF6 polyubiquitination."
22984582
SCN8A dephosphorylates MAP3K7.
| 1
SCN8A leads to the dephosphorylation of MAP3K7. 1 / 1
| 1
reach
"MED significantly inhibited TAK1 phosphorylation and TRAF6 polyubiquitination, but not IRAK1 phosphorylation and TRAF6 dimerization, indicating that MED inhibits LPS induced inflammatory responses at least in part through suppression of TRAF6 polyubiquitination."
22984582
SCN8A affects LYST
| 3
SCN8A inhibits LYST. 3 / 3
| 3
reach
"However, a single suberythemal exposure of either 0.25 or 0.5 MED suppressed CHS responses by 50 and 80%, respectively, in skin types I/II, whereas 1 MED only suppressed CHS by 40% in skin types III/IV."
10662801
reach
"A moderate but vivid sunburn (2 MED) completely suppressed CHS (93%) in all volunteers regardless of skin type, but skin types I/II were more sensitive to suberythemal exposure."
10662801
reach
"Not only did low-dose UVR suppress local CHS responses, but our previous studies showed that 3 MED SSR suppressed CHS responses by 93% (12/12 volunteers) when sensitizer was applied to irradiated skin and also suppressed CHS responses by the same amount (10/12 volunteers) when sensitizer was applied at a distant site 24 h after irradiation 10."
10662801
SCN8A affects Heart Rate
| 3
SCN8A inhibits Heart Rate. 3 / 3
| 3
reach
"MED infusion alone increased SAP maximally by 24.9%, MAP by 34.7% and a-vO2 diff by 222.5%, and reduced HR by 32.3%, but these changes were significantly attenuated by MK-467."
25201249
reach
"The I max estimates indicate that MED and DEX reduce the HR by 31%, while DET reduces HR by approximately 51%."
25073816
reach
"However, the MED trial significantly attenuated the exercise induced increase in HR."
28562650
SCN8A affects Collagen
| 3
SCN8A activates Collagen.
| 2
SCN8A activates Collagen. 2 / 2
| 2
reach
"3 In contrast, autosomal dominant MED is genetically heterogeneous and although in the European population the largest proportion results from COMP mutations, other forms of MED can be caused by mutations in the genes encoding matrilin-3 (MATN3) and type IX collagen (COL9A1, COL9A2 and COL9A3)."
24595329
reach
"This finding is especially important given the role of type XIV in collagen fibrillogenesis, the known disruption to collagen fibrillogenesis caused by an MED causing COMP mutation and the previous finding of altered collagen fibril morphology in Matn3 V194D, Comp DelD469 and Comp T585M cartilages (supplementary material Fig."
23951406
SCN8A increases the amount of Collagen.
| 1
SCN8A increases the amount of Collagen. 1 / 1
| 1
reach
"Moreover, MED and SEMD mutations cause increased collagen X expression, resulting in premature hypertrophy [XREF_BIBR]."
27104523
SCN8A affects CELF4
| 3
SCN8A binds CELF4. 3 / 3
| 3
reach
"As part of a related study, we find that CELF4 directly binds Scn8a mRNA, encoding sodium channel Na (v) 1.6, the primary instigator of AP at the axon initial segment (AIS) and the main carrier of I (NaP)."
23090952
reach
"Such effects may well be related to function in the pyramidal neuron AIS, as Na V 1.6 expression is significantly higher in epileptic mice deficient for CELF4, an RNA binding protein that binds to Scn8a mRNA [XREF_BIBR]."
24657915
reach
"CELF4 binds Scn8a mRNA and in the absence of CELF4, Nav1.6 channels are dramatically overexpressed at axon initial segments suggesting they may play a role in seizure generation by increasing action potential initiation in this model [XREF_BIBR]."
24139807
SCN8A affects CDYL
| 3
SCN8A increases the amount of CDYL.
| 2
SCN8A increases the amount of CDYL. 2 / 2
| 2
reach
"Together, these results support an argument that CDYL inhibits SCN8A transcription mainly through recruiting H3K27me3 methyltransferase activity, possibly also the HDAC activity albeit to a less degree, to the intronic silencer of the gene."
28842554
reach
"We next performed ChIP analysis to investigate the molecular mechanism by which CDYL regulates SCN8A transcription."
28842554
SCN8A activates CDYL.
| 1
SCN8A activates CDYL. 1 / 1
| 1
reach
"Quantitative real-time RT-PCR and western blot assays both confirmed that the level of SCN8A was increased in mouse and rat DG granule cells infected with CDYL-shRNA lentiviruses, whereas SCN8A expression was decreased in the hippocampus of transgenic mice over-expressing CDYL."
28842554
FGF13 affects SCN8A
2 1 |
FGF13 binds SCN8A.
1 1 |
SCN8A binds FGF13. 2 / 2
1 1 |
hprd
No evidence text available
15282281
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF13 inhibits SCN8A.
1 |
FGF13 inhibits SCN8A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
COL9A1 affects SCN8A
| 3
COL9A1 activates SCN8A. 3 / 3
| 3
reach
"Therefore, it was surprising that the splice site mutation in COL9A1 that causes MED did not result in skipping of exon 9."
16909383
reach
"Mutations in the COMP, COL9A1, COL9A2, COL9A3, MATN3 and SLC26A2 genes cause approximately 70% of multiple epiphyseal dysplasia (MED) cases."
30740902
reach
"The results show that mutations in COL9A1 can cause MED, but they also suggest that mutations in COL9A1, COL9A2, COL9A3, COMP, and DTDST are not the major causes of MED and that there exists at least one additional locus."
11565064
CELF4 affects SCN8A
| 3
SCN8A binds CELF4. 3 / 3
| 3
reach
"As part of a related study, we find that CELF4 directly binds Scn8a mRNA, encoding sodium channel Na (v) 1.6, the primary instigator of AP at the axon initial segment (AIS) and the main carrier of I (NaP)."
23090952
reach
"Such effects may well be related to function in the pyramidal neuron AIS, as Na V 1.6 expression is significantly higher in epileptic mice deficient for CELF4, an RNA binding protein that binds to Scn8a mRNA [XREF_BIBR]."
24657915
reach
"CELF4 binds Scn8a mRNA and in the absence of CELF4, Nav1.6 channels are dramatically overexpressed at axon initial segments suggesting they may play a role in seizure generation by increasing action potential initiation in this model [XREF_BIBR]."
24139807
Sodium atom affects SCN8A
| 2
Sodium atom activates SCN8A. 2 / 2
| 2
reach
"This increase in the frequency of SWDs during postnatal development coincides with previously described developmental increases in Na v 1.6 levels (protein product of Scn8a)."
28238546
reach
"The identification of this new gain-of-function mutation of Na v 1.6 supports the inclusion of SCN8A as a causative gene in infantile epilepsy, demonstrates a novel mechanism for hyperactivity of Na v 1.6, and further expands the role of de novo mutations in severe epilepsy."
24874546
Sodium 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate affects SCN8A
| 2
Sodium 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate inhibits SCN8A. 1 / 1
| 1
reach
"Preexposure of hairless mice to several sub-MED levels of simulated solar radiation (SSR) specifically suppresses induction of 24-h ODC by a follow-up 2 x MED of SSR."
2302717
Sodium 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate activates SCN8A. 1 / 1
| 1
reach
"The mean physical SSR dose required to induce a MED in skin types I/II was about twofold lower than for skin types III/IV : 3.2 and 5.5 J.cm -2, respectively (P < 0.001)."
10662801
Memantine affects SCN8A
| 2
Memantine inhibits SCN8A. 2 / 2
| 2
reach
"CHF3381 suppressed the maintenance of carrageenan induced thermal and mechanical hyperalgesia in the rat with a minimum significantly effective dose (MED) of 30 mg/kg p.o. Memantine produced a partial reversal of both thermal and mechanical hyperalgesia (MED = 10 and 15 mg/kg i.p., respectively)."
12750440
reach
"In the mouse formalin test, CHF3381 and memantine preferentially inhibited the late phase (MED = 30 and 20 mg/kg i.p., respectively); gabapentin inhibited only the late phase (MED = 30 mg/kg s.c.)."
12750440
Flavone affects SCN8A
| 2
Flavone activates SCN8A. 2 / 2
| 2
reach
"This includes the induction of BtGST2 by I3C in the MED species, and by flavone and AITC in both species, the induction of COE2 by caffeine and flavone in the MED species and the induction of CYP6 like 5 by flavone in both species and by quercetin in the MED species."
26655836
reach
"This includes the induction of BtGST2 by I3C in the MED species, and by flavone and AITC in both species, the induction of COE2 by caffeine and flavone in the MED species and the induction of CYP6 like 5 by flavone in both species and by quercetin in the MED species (XREF_FIG)."
26655836
Cre affects SCN8A
| 1 1
Cre inhibits SCN8A. 2 / 2
| 1 1
sparser
"Lentiviral Cre -induced inactivation of the Scn8a gene in the hippocampus reduces seizure generation in vivo ."
24704313
reach
"Global Cre mediated deletion of a heterozygous floxed Scn8a allele in adult mice was found to increase thresholds to chemically and electrically induced seizures."
24704313
Caffeine affects SCN8A
| 2
Caffeine activates SCN8A. 2 / 2
| 2
reach
"This includes the induction of BtGST2 by I3C in the MED species, and by flavone and AITC in both species, the induction of COE2 by caffeine and flavone in the MED species and the induction of CYP6 like 5 by flavone in both species and by quercetin in the MED species."
26655836
reach
"This includes the induction of BtGST2 by I3C in the MED species, and by flavone and AITC in both species, the induction of COE2 by caffeine and flavone in the MED species and the induction of CYP6 like 5 by flavone in both species and by quercetin in the MED species (XREF_FIG)."
26655836
Apomorphine affects SCN8A
| 2
Apomorphine activates SCN8A. 2 / 2
| 2
reach
"In contrast pardoprunox attenuated novelty induced locomotor activity (MED = 0.01 mg/kg; po), (+)-amphetamine-induced hyperlocomotion (MED = 0.3 mg/kg; po) and apomorphine induced climbing (MED = 0.6 mg/kg; po) in rodents."
20434890
reach
"In models sensitive to antipsychotic drug treatment, ADX47273 reduced rat conditioned avoidance responding [minimal effective dose (MED) = 30 mg/kg i.p.] and decreased mouse apomorphine induced climbing (MED = 100 mg/kg i.p.), with little effect on stereotypy or catalepsy."
18753411
UVR affects SCN8A
| 2
UVR activates SCN8A. 2 / 2
| 2
reach
"The UVR needed to produce an MED in Asians, with their darker skin, was greater (49-133 mJ/cm2) than that required in Caucasians (31-48 mJ/cm2)."
3766454
reach
"The dose response curve of UVR induced erythema showed a significant flattening and the MED increased from 103 +/- 29 mJ/cm2 (before supplementation) to 183 +/- 35 mJ/cm2 (after supplementation) in group (3), while there were no significant changes in groups (1) and (2) after vitamin supplementation."
9870553
TST affects SCN8A
| 2
TST activates SCN8A. 2 / 2
| 2
reach
"Mean MED (mg) decreased by 21 mg in TST group and increased by 2.5 mg in non TST group (p <.05)."
28625114
reach
"Median MED (mg) decreased by 21 mg in TST group and increased by 2.5 mg in non TST group (p <.05; XREF_TABLE)."
28625114
SCN8A affects transcription, DNA-templated
| 2
SCN8A activates transcription, DNA-templated. 1 / 1
| 1
reach
"Strikingly, Psi was found in complex with most subunits of the transcriptional Mediator (MED) complex, which interacts with the RNA Pol II machinery to modulate transcription in all eukaryotes."
27207882
SCN8A bound to CRSP activates transcription, DNA-templated. 1 / 1
| 1
reach
"It has been well established that in addition to TFIID, the multi and subunit complex CRSP and MED can function to mediate activator dependent transcription."
18851836
SCN8A affects phosphatidylinositol
| 2
SCN8A inhibits phosphatidylinositol.
| 1
SCN8A inhibits phosphatidylinositol. 1 / 1
| 1
reach
"The addition of C1b, MED, ENTH, or filipin inhibited PI (3) P vertex enrichment (P < 0.00001; XREF_FIG A)."
15611334
Phosphatidylinositol binds SCN8A. 1 / 1
| 1
reach
"Though MED is bound mainly to PI (4,5) P 2 in cells, it can also bind PI (3,4) P 2, PI (4) P and PI (3) P (unpublished data)."
15611334
SCN8A affects metabolic process
| 2
SCN8A inhibits metabolic process.
| 1
SCN8A inhibits metabolic process. 1 / 1
| 1
reach
"Taken together, this indicates that MED genotypes may have already reduced the capacity of major carbon and nitrogen metabolism at 3 d after stress establishment, which does not occur to the same extent in GER genotypes."
28338908
SCN8A activates metabolic process.
| 1
SCN8A activates metabolic process. 1 / 1
| 1
reach
"In contrast, doses of d MED as low as 30 micrograms/kg cause sedation, hypothermia and induce neurochemical changes in norepinephrine and 5-hydroxytryptamine metabolism in brain characteristic of alpha-2-agonists (decreases in concentrations of biogenic amine metabolites, turnover and increases in concentration of parent amine)."
1682487
SCN8A affects inflammatory response
| 2
SCN8A inhibits inflammatory response. 1 / 1
| 1
reach
"To determine whether MED could suppress inflammation in mice after 8weeks of HFD feeding, the levels of inflammatory cytokines, including TNF-alpha, IL-6, and IL-1beta, in plasma and the aortic arch of HFD fed ApoE deficient mice were measured."
26045945
SCN8A activates inflammatory response.
| 1
SCN8A activates inflammatory response. 1 / 1
| 1
reach
"These results indicate that MED can inhibit atherosclerosis at least in part by suppressing inflammation in vivo."
26045945
SCN8A affects glutathione
| 2
SCN8A decreases the amount of glutathione. 2 / 2
| 2
reach
"A single UV exposure of 4x MED to human skin was found to increase catalase activity (109-145%) and decrease glutathione peroxidase (GPx) activity (36-54%) and total glutathione (GSH) level (13-36%) at different time points studied."
11181450
reach
"A single UV exposure of 4x MED to human skin was found to increase catalase activity (109-145%) and decrease glutathione peroxidase (GPx) activity (36-54%) and total glutathione (GSH) level (13-36%) at different time points studied."
11181450
SCN8A affects cell population proliferation
| 2
SCN8A inhibits cell population proliferation. 1 / 1
| 1
reach
"Collectively, MED significantly suppressed proliferation and invasion of CCA cells such as SK-ChA-1 and Mz-ChA-1, suggesting that MED is a potential lead compound for the development of novel drugs for therapy of CCA."
24486723
Mutated SCN8A inhibits cell population proliferation. 1 / 1
| 1
reach
"MED mutations cluster predominantly in the beta-sheets of the single A-domain of matrilin-3 and result in a canonical ER stress response with dysregulated chondrocyte apoptosis and decreased proliferation in the cartilage growth plate."
24312420
SCN8A affects TNFSF11
| 2
SCN8A inhibits TNFSF11. 2 / 2
| 2
reach
"In this study, we showed that MED could inhibit receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation and the expression of three well-known osteoclast markers such as tartrate resistant acid phosphatase, calcitonin receptor, and cathepsin K in bone marrow derived macrophages."
22678021
reach
"Taken together, we demonstrate for the first time that MED can suppress RANKL induced osteoclast differentiation in vitro and ovariectomy induced osteoporosis in vivo, suggesting that MED is a potential lead compound for the development of novel drugs for osteoporosis treatment."
22678021
SCN8A affects PLCG1
| 2
SCN8A phosphorylates PLCG1.
| 1
SCN8A leads to the phosphorylation of PLCG1. 1 / 1
| 1
reach
"Furthermore, we found that MED suppressed antigen induced activation of Syk, and subsequently inhibited the phosphorylation of PLCgamma1, Akt, and MAPKs such as extracellular signal regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 in mast cells."
23859869
SCN8A dephosphorylates PLCG1.
| 1
SCN8A leads to the dephosphorylation of PLCG1. 1 / 1
| 1
reach
"Furthermore, we found that MED suppressed antigen induced activation of Syk, and subsequently inhibited the phosphorylation of PLCgamma1, Akt, and MAPKs such as extracellular signal regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 in mast cells."
23859869
SCN8A affects Neoplasm Invasiveness
| 2
SCN8A inhibits Neoplasm Invasiveness. 1 / 1
| 1
reach
"Collectively, MED significantly suppressed proliferation and invasion of CCA cells such as SK-ChA-1 and Mz-ChA-1, suggesting that MED is a potential lead compound for the development of novel drugs for therapy of CCA."
24486723
SCN8A activates Neoplasm Invasiveness.
| 1
SCN8A activates Neoplasm Invasiveness. 1 / 1
| 1
reach
"THP-1 invasion also was inhibited by small hairpin RNA knockdown of SCN8A."
19136557
SCN8A affects NEDD4
1 | 1
SCN8A binds NEDD4. 2 / 2
1 | 1
biogrid
No evidence text available
20530479
sparser
"The E3 ubiquitin ligase Nedd4 also binds to the C-terminus of Scn8a at a PXY motif (residues 1943–1945), and the PXpS/pTP motif in the first cytoplasmic loop (residues 551–554) (Abriel et al., xref ; Sudol and Hunter, xref ; Fotia et al., xref ; Ingham et al., xref ; van Bemmelen et al., xref ; Rougier et al., xref )."
24194747
SCN8A affects MAPK
| 2
SCN8A activates MAPK. 2 / 2
| 2
reach
"MED inhibited LPS induced nuclear translocation of nuclear factor (NF)-kappaB (NF-kappaB) p65, IkappaB degradation, IkappaB kinase (IKK) phosphorylation, and the activation of extracellular signal regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38, suggesting that MED blocks the activation of both NF-kappaB and mitogen activated protein kinase (MAPK) pathways."
22984582
reach
"Additionally, MED activated MAPK pathways."
20970330
SCN8A affects LPS with O-antigen
| 2
SCN8A inhibits LPS with O-antigen. 2 / 2
| 2
reach
"Mycoepoxydiene Inhibits Lipopolysaccharide Induced Inflammatory Responses through the of TRAF6 Polyubiquitination."
22984582
reach
"Additionally, MED effectively prevented LPS induced endotoxin shock in mice."
22984582
SCN8A affects LDH
| 2
SCN8A activates LDH. 2 / 2
| 2
reach
"A total of 151 patients with LDH were treated with MED and followed postoperatively for up to 10 years."
22825836
reach
"A retrospective study was performed in patients with LDH treated with MED (n = 50) and transforaminal endoscopic discectomy (PTED; n = 36) in our hospital."
26713113
SCN8A affects IRAK1
| 2
SCN8A dephosphorylates IRAK1.
| 1
SCN8A leads to the dephosphorylation of IRAK1. 1 / 1
| 1
reach
"MED significantly inhibited TAK1 phosphorylation and TRAF6 polyubiquitination, but not IRAK1 phosphorylation and TRAF6 dimerization, indicating that MED inhibits LPS induced inflammatory responses at least in part through suppression of TRAF6 polyubiquitination."
22984582
SCN8A activates IRAK1.
| 1
SCN8A activates IRAK1. 1 / 1
| 1
reach
"As shown in XREF_FIG, MED had no significant effects on the phosphorylation of IRAK1 at 10, 20, and 30 min after LPS treatment, although MED markedly inhibited the degradation of IRAK1 at 30 min after LPS treatment."
22984582
SCN8A affects Glu-Asp
| 2
SCN8A inhibits Glu-Asp. 2 / 2
| 2
reach
"TExT MED also decreased ED utilization."
24225332
reach
"We seek to determine whether a scalable, low-cost, unidirectional, text message based mobile health intervention (TExT MED) improves clinical outcomes, increases healthy behaviors, and decreases ED utilization in a safety net population."
24225332
SCN8A affects FGF13
1 1 |
SCN8A binds FGF13. 2 / 2
1 1 |
hprd
No evidence text available
15282281
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN8A affects FBXW11
| 2
SCN8A activates FBXW11. 2 / 2
| 2
reach
"In one study, elevated levels of 8-OH-Gua were found in HOS : Hr-1 albino mouse skin that was chronically treated with 2 or 10 MED UVB three times per week and harvested immediately after the final UVB exposure [XREF_BIBR]."
27818081
reach
"In one study, elevated levels of 8-OH-Gua were found in HOS : Hr-1 albino mouse skin that was chronically treated with 2 or 10 MED UVB three times per week and harvested immediately after the final UVB exposure [7]."
27818081
SCN8A affects FBP1
| 2
SCN8A binds FBP1. 2 / 2
| 2
reach
"Further studies are required to determine whether human FBP1 also interacts with MED as we predict this interaction will also modulate expression of the MYC oncogene."
27207882
reach
"As FBP1 has been implicated in controlling expression of the MYC oncogene, we predict interaction between MED and FBP1 might also have implications for cancer initiation and progression."
27207882
SCN8A affects ERK
| 2
SCN8A phosphorylates ERK.
| 1
SCN8A leads to the phosphorylation of ERK. 1 / 1
| 1
reach
"Moreover, MED suppressed NF-kappaB activation by blocking IkappaB-alpha (IkappaB-alpha) degradation and inhibited the phosphorylation of ERK 1/2 and toll like receptor 4 (TLR4) expression, but had no effect on the phosphorylation of JNK, and p38."
24447679
SCN8A activates ERK.
| 1
SCN8A activates ERK. 1 / 1
| 1
reach
"However, MED also induces the MEK and ERK pathway, which is classically considered to promote cell survival."
25014191
SCN8A affects DKK1
| 2
SCN8A activates DKK1. 2 / 2
| 2
reach
"MED has shown its effectiveness in deconvolving the impulses from a mixture of response signals and has been used to enhance the performance of SK in bearing fault detection and diagnosis."
26610501
reach
"Through the literature review, we notice that MED enhances the performance of SK because it could sharpen the impulses and increase the kurtosis of the signals."
26610501
SCN8A affects COMP
| 2
SCN8A activates COMP. 1 / 1
| 1
reach
"In contrast, COMP-null mice show no differences in collagen fibril diameter and these data therefore suggest that PSACH and MED causing mutations in matrilin-3 and COMP can cause changes in the ultra-structure of the cartilage ECM through antimorphic mechanisms."
23951406
SCN8A activates mutated COMP. 1 / 1
| 1
reach
"This finding is especially important given the role of type XIV in collagen fibrillogenesis, the known disruption to collagen fibrillogenesis caused by an MED causing COMP mutation and the previous finding of altered collagen fibril morphology in Matn3 V194D, Comp DelD469 and Comp T585M cartilages (supplementary material Fig."
23951406
SCN8A affects CD36
| 2
SCN8A inhibits CD36.
| 1
SCN8A inhibits CD36. 1 / 1
| 1
reach
"This was not simply by coincidence because UV irradiation (2 MED) of human buttock skin dramatically decreased the levels of free fatty acids and triglycerides in the underlying subcutaneous fat."
22170486
SCN8A activates CD36.
| 1
SCN8A activates CD36. 1 / 1
| 1
reach
"However, the diets varied considerably in fatty acid content, and the WEST diet increased fat deposition in the liver by approximately 40%, whereas the MED diet increased fat in the liver by only approximately 14%."
31012294
SCN8A affects CCT4
| 2
SCN8A binds CCT4. 2 / 2
| 2
reach
"In the WAG and OXYS -1.1 versus OXYS comparison, DAVID revealed significant enrichment in GO terms relevant to the Srb and mediator complex, peroxisomes, and regulation of neurotransmitter release."
25563673
reach
"For example, for Gcn4 these include SAGA, SWI/SNF and RSC chromatin remodeling complexes, the SRB and MED complex, the transcriptional regulator CCR4-NOT, and the repressive Cyc8 and Tup1 complex XREF_BIBR - XREF_BIBR."
25766875
SCN8A affects CASP3
| 2
SCN8A increases the amount of CASP3. 2 / 2
| 2
reach
"Ligation of the main excretory duct (MED) of the mouse submandibular gland (SMG) induced the expression of Sca-1, a stem cell marker."
20224192
reach
"Ligation of the MED of the SMG in mice induced the expression of Sca-1, a protein marker of hematopoietic stem cells."
21868636
SCN8A affects APOE
| 2
SCN8A inhibits APOE. 2 / 2
| 2
reach
"Moreover, MED dramatically reduced the occurrence of HFD induced atherosclerotic lesions in ApoE -/- mice."
26045945
reach
"MED effectively reduces atherosclerotic lesions in ApoE -/- mice."
26045945
SCN8A affects AGT
| 2
SCN8A inhibits AGT.
| 1
SCN8A inhibits AGT. 1 / 1
| 1
reach
"Enalapril Inhibits MED Resulting Increase of Ang II Induced Contractile Response."
26640794
SCN8A activates AGT.
| 1
SCN8A activates AGT. 1 / 1
| 1
reach
"These results demonstrated that MED resulted in increase of Ang II induced contractile response which could be inhibited by enalapril treatment."
26640794
SCN8A affects (R)-noradrenaline
| 2
SCN8A inhibits (R)-noradrenaline.
| 1
SCN8A inhibits (R)-noradrenaline. 1 / 1
| 1
reach
"MED (0.1-300 nM) reduced the DMPP evoked overflow (DMPP 500 muM) of noradrenaline and adrenaline in a concentration dependent manner and was capable of totally inhibiting this effect."
21518261
SCN8A activates (R)-noradrenaline.
| 1
SCN8A activates (R)-noradrenaline. 1 / 1
| 1
reach
"In contrast, doses of d MED as low as 30 micrograms/kg cause sedation, hypothermia and induce neurochemical changes in norepinephrine and 5-hydroxytryptamine metabolism in brain characteristic of alpha-2-agonists (decreases in concentrations of biogenic amine metabolites, turnover and increases in concentration of parent amine)."
1682487
SCN8A affects (R)-adrenaline
| 2
SCN8A inhibits (R)-adrenaline. 2 / 2
| 2
reach
"MED decreased baseline epinephrine and prevented the IH induced increase in epinephrine, whereas the norepinephrine response remained intact."
25179887
reach
"MED (0.1-300 nM) reduced the DMPP evoked overflow (DMPP 500 muM) of noradrenaline and adrenaline in a concentration dependent manner and was capable of totally inhibiting this effect."
21518261
NEDD4L affects SCN8A
2 | 2
NEDD4L ubiquitinates SCN8A.
1 |
NEDD4L ubiquitinates SCN8A. 1 / 1
1 |
signor
"The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2)."
23778145
NEDD4L decreases the amount of SCN8A.
1 | 2
NEDD4L decreases the amount of SCN8A. 1 / 1
1 | 2
signor
"The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2)."
23778145
NEDD4 affects SCN8A
1 | 1
SCN8A binds NEDD4. 2 / 2
1 | 1
biogrid
No evidence text available
20530479
sparser
"The E3 ubiquitin ligase Nedd4 also binds to the C-terminus of Scn8a at a PXY motif (residues 1943–1945), and the PXpS/pTP motif in the first cytoplasmic loop (residues 551–554) (Abriel et al., xref ; Sudol and Hunter, xref ; Fotia et al., xref ; Ingham et al., xref ; van Bemmelen et al., xref ; Rougier et al., xref )."
24194747
LSM-4015 affects SCN8A
| 2
LSM-4015 inhibits SCN8A.
| 1
LSM-4015 inhibits SCN8A. 1 / 1
| 1
reach
"The muscarinic cholinergic agonist carbachol induced depolarization in all PR neurons tested, and the muscarinic cholinergic antagonist scopolamine reduced or blocked carbachol- and PPN stimulation induced PRs in all MED neurons tested."
15890754
LSM-4015 activates SCN8A.
| 1
LSM-4015 activates SCN8A. 1 / 1
| 1
reach
"In the reference memory test, all the compounds reversed the effects of a scopolamine induced deficit with L-687,306 being the most potent (MED = 0.01 mg/kg)."
8117420
INS affects SCN8A
2 |
Transcriptionally active INS decreases the amount of SCN8A. 2 / 2
2 |
biopax:ctd
No evidence text available
28628672
biopax:ctd
No evidence text available
28628672
FGF12 affects SCN8A
2 |
FGF12 inhibits SCN8A.
1 |
FGF12 inhibits SCN8A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF12 binds SCN8A.
1 |
SCN8A binds FGF12. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF11 affects SCN8A
2 |
FGF11 inhibits SCN8A.
1 |
FGF11 inhibits SCN8A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF11 binds SCN8A.
1 |
SCN8A binds FGF11. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FBP1 affects SCN8A
| 2
SCN8A binds FBP1. 2 / 2
| 2
reach
"Further studies are required to determine whether human FBP1 also interacts with MED as we predict this interaction will also modulate expression of the MYC oncogene."
27207882
reach
"As FBP1 has been implicated in controlling expression of the MYC oncogene, we predict interaction between MED and FBP1 might also have implications for cancer initiation and progression."
27207882
CHF3381 affects SCN8A
| 2
CHF3381 inhibits SCN8A. 2 / 2
| 2
reach
"In diabetic neuropathy, CHF3381 reversed mechanical hyperalgesia (MED = 50 mg/kg p.o.)."
12750440
reach
"In rats with a sciatic nerve injury, CHF3381 relieved both cold and mechanical allodynia (MED = 100 mg/kg p.o.)."
12750440
CCT4 affects SCN8A
| 2
SCN8A binds CCT4. 2 / 2
| 2
reach
"In the WAG and OXYS -1.1 versus OXYS comparison, DAVID revealed significant enrichment in GO terms relevant to the Srb and mediator complex, peroxisomes, and regulation of neurotransmitter release."
25563673
reach
"For example, for Gcn4 these include SAGA, SWI/SNF and RSC chromatin remodeling complexes, the SRB and MED complex, the transcriptional regulator CCR4-NOT, and the repressive Cyc8 and Tup1 complex XREF_BIBR - XREF_BIBR."
25766875
CALM1 affects SCN8A
2 |
CALM1 inhibits SCN8A.
1 |
CALM1 inhibits SCN8A. 1 / 1
1 |
signor
"Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1) in a Ca2+-dependent manner. This binding interaction significantly enhances slow inactivation-a channel-gating process linked to life-threatening idiopathic ventricular arrhythmias."
11807557
CALM1 binds SCN8A.
1 |
SCN8A binds CALM1. 1 / 1
1 |
signor
"Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1) in a Ca2+-dependent manner. This binding interaction significantly enhances slow inactivation-a channel-gating process linked to life-threatening idiopathic ventricular arrhythmias."
11807557
CALM affects SCN8A
| 2
CALM binds SCN8A.
| 1
CALM binds SCN8A. 1 / 1
| 1
reach
"MED sequesters phosphatidylinositol-4,5-bisphosphate, binds calmodulin with a K d of 4 nM, and penetrates the acyl chain zone of lipid bilayers with its five phenylalanines."
16365164
CALM activates SCN8A.
| 1
CALM activates SCN8A. 1 / 1
| 1
reach
"We have found that the GAC repeats in the 7th calmodulin like repeat in exon 13 represent a hot-spot for mutation, and that mutations in the 7th calmodulin like repeat produce severe PSACH phenotypes while mutations elsewhere in the gene exhibit mild PSACH or MED phenotypes."
9921895
BRD4 affects SCN8A
| 2
BRD4 binds SCN8A.
| 1
SCN8A binds BRD4 and BET bromodomain. 1 / 1
| 1
reach
"Supporting a functional interaction of BRD4 and MED at super-enhancers, BET bromodomain inhibition releases the mediator complex from select cis-regulatory elements, at least in leukemia cells [XREF_BIBR]."
29415456
BRD4 activates SCN8A.
| 1
BRD4 activates SCN8A. 1 / 1
| 1
reach
"However, inhibition of BRD4 by JQ1 abolishes binding of the entire MED complex at multiple sites across the genome of acute myeloid leukemia (AML) cells, including the MYC promoter [XREF_BIBR]."
28398229
B. tabaci affects SCN8A
| 2
B. tabaci activates SCN8A. 2 / 2
| 2
reach
"The GroEL produced by other symbionts of B. tabaci (MEAM1 and MED) did not interact with the virus and therefore were not involved in virus transmission [XREF_BIBR]."
29053633
reach
"The GroEL produced by other symbionts of B. tabaci (MEAM1 and MED) did not interact with the virus and therefore were not involved in virus transmission [XREF_BIBR]."
30052670
ADX47273 affects SCN8A
| 2
ADX47273 inhibits SCN8A.
| 1
ADX47273 inhibits SCN8A. 1 / 1
| 1
reach
"In cognition models, ADX47273 increased novel object recognition (MED = 1 mg/kg i.p.) and reduced impulsivity in the five-choice serial reaction time test (MED = 10 mg/kg i.p.) in rats."
18753411
ADX47273 activates SCN8A.
| 1
ADX47273 activates SCN8A. 1 / 1
| 1
reach
"In cognition models, ADX47273 increased novel object recognition (MED = 1 mg/kg i.p.) and reduced impulsivity in the five-choice serial reaction time test (MED = 10 mg/kg i.p.) in rats."
18753411
(+)-alpha-tocopherol affects SCN8A
| 2
(+)-alpha-tocopherol inhibits SCN8A.
| 1
(+)-alpha-tocopherol inhibits SCN8A. 1 / 1
| 1
reach
"In mice, systemic vitamin E reduced MED, lipid oxidation, and incorporation of thymine dimers in DNA (Record et al, 1991)."
15675947
(+)-alpha-tocopherol activates SCN8A.
| 1
(+)-alpha-tocopherol activates SCN8A. 1 / 1
| 1
reach
"In a retrospective human study, the combination of ascorbic and a-tocopherol during 7 weeks increased the MED by 77.6% (from 103 +/- 29 mJ/cm 2 before supplementation to 183 +/- 35 mJ/cm 2)."
29998107
Trovafloxacin affects SCN8A
| 1
Trovafloxacin inhibits SCN8A. 1 / 1
| 1
reach
"Similarly, at 365 +/- 30 nm, trovafloxacin produced the smallest reduction in delayed MED versus placebo (43.66%), compared with ciprofloxacin (61.53%) and lomefloxacin (75.81%)."
10747828
Tridecane affects SCN8A
| 1
Tridecane binds SCN8A. 1 / 1
| 1
reach
"The hazard ratio estimating the association between higher MED and TRD remained non significant after adding pain variables in model 3 (HR = 1.07; 95% CI :0.88 -1.30)."
27497660
Tetrodotoxin affects SCN8A
| 1
Tetrodotoxin binds SCN8A. 1 / 1
| 1
reach
"It is known that SCN1A (Smith et al., 1998), SCN2A (Noda et al., 1986; Suzuki et al., 1988; Smith et al., 1998), SCN3A (Suzuki et al., 1988), and SCN8A (Smith et al., 1998) alpha subunits bind tetrodotoxin and STX with comparable affinities."
10827969
Sodium(1+) affects SCN8A
| 1
Sodium(1+) activates SCN8A. 1 / 1
| 1
reach
"Mapping and candidate gene sequencing showed a novel mutation in the neuronal voltage gated sodium channel (VGSC) alpha-subunit Scn8a, causing a non synonymous change in the SCN8A peptide."
19737145
Selenomethionine affects SCN8A
| 1
Selenomethionine activates SCN8A. 1 / 1
| 1
reach
"A response curve demonstrated that increasing concentrations of topical L-selenomethionine gave increasing MED, with a plateau of maximal protection attained at a concentration between 0.02% and 0.05%."
1489715
Ritanserin affects SCN8A
| 1
Ritanserin inhibits SCN8A. 1 / 1
| 1
reach
"Similarly, the selective 5-HT2A/2C antagonist ritanserin (0.001-1.0 mg/kg) alone had no effect on locomotor activity, but reversed (MED = 0.01 mg/kg) the effects of PCP."
9122367
Protein affects SCN8A
| 1
Protein activates SCN8A. 1 / 1
| 1
reach
"Muscle protein synthesis in MED myopathy."
881784
Progesterone affects SCN8A
| 1
Progesterone activates SCN8A. 1 / 1
| 1
reach
"While the magnitude of progesterone induced alterations in affinity were similar in FC, MED and HIP, HPO affected the affinity significantly stronger in HIP than in HYP and MED."
8101089
Pregabalin affects SCN8A
| 1
Pregabalin inhibits SCN8A. 1 / 1
| 1
reach
"Pregabalin also reduced paw licking and late phase (MED = 0.63), but was inactive up to 160mg/kg for paw elevation (both phases) and paw licking (early phase)."
19883699
Polymerase affects SCN8A
| 1
SCN8A binds polymerase. 1 / 1
| 1
reach
"The phosphorylation status of the highly repetitive heptads in the carboxyl (C)-terminal domain (CTD) of the largest PolII subunit Rpb1 is thought to play a critical role in orchestrating the interaction between the yeast polymerase and MED."
18515835
Phosphatidylinositol affects SCN8A
| 1
Phosphatidylinositol binds SCN8A. 1 / 1
| 1
reach
"Though MED is bound mainly to PI (4,5) P 2 in cells, it can also bind PI (3,4) P 2, PI (4) P and PI (3) P (unpublished data)."
15611334
Phenytoin affects SCN8A
| 1
Phenytoin activates SCN8A. 1 / 1
| 1
reach
"We studied the effects of 0.5 mg/kg IV atracurium in 53 neurosurgical patients : 21 nonepileptic patients receiving no anticonvulsant therapy (MED = 0); 14 epileptic patients treated with carbamazepine for years (MED = 1); and 18 epileptic patients treated with carbamazepine plus either phenytoin or valproic acid for years (MED = 2)."
2240640
Phenazine-1-carboxylate affects SCN8A
| 1
Phenazine-1-carboxylate activates SCN8A. 1 / 1
| 1
reach
"This study includes a large proportion of patients requiring long-term PCA which may lead to overall increased MED around the time of death due to opioid tolerance and dependence in the context of chronic use."
25820345
P.Asp473dup affects SCN8A
| 1
P.Asp473dup activates SCN8A. 1 / 1
| 1
reach
"It is an interesting observation that p.Asp473del consistently causes PSACH, while p.Asp473dup always causes MED."
21922596
Monensin A affects SCN8A
| 1
Monensin A activates SCN8A. 1 / 1
| 1
reach
"Monensin increased the IVDMD of GUN and MED, but it decreased the IVDMD of HAR."
9690651
MiR-30b affects SCN8A
| 1
MiR-30b inhibits SCN8A. 1 / 1
| 1
reach
"Moreover, we found that miR-30b negatively regulated Scn8a by binding to the Scn8a 3 ' UTR in PC12cells."
31054938
MiR-106b affects SCN8A
| 1
MiR-106b inhibits SCN8A. 1 / 1
| 1
reach
"In another study, it was observed that inhibition of miR-106b can induce G1 arrest and apoptosis in MED cells."
29658967
Metamizole sodium affects SCN8A
| 1
Metamizole sodium inhibits SCN8A. 1 / 1
| 1
reach
"The combined i.m. administration of dipyrone with IEM-1460 and spermine in threshold, noneffective alone doses according 1/5 part from their MED leads to decrease of MED dipyrone in the combination with IEM-1460 in 120 times, and MED dipyrone in combination with spermine -- in 10 times."
25464766
Melatonin affects SCN8A
| 1
Melatonin activates SCN8A. 1 / 1
| 1
reach
"6 Hydroxylation of melatonin raises the MED 103 times and all other additions or subtractions of groups, or changes in structure, either abolish activity or raise the MED 105 times, to the level of possibly indirect, toxic, and nonspecific response."
5674699
Med-ORF12 affects SCN8A
| 1
Med-ORF12 activates SCN8A. 1 / 1
| 1
reach
"Meanwhile, introduction of med-ORF12 into this mutant strain could restore the production of MED 2."
26162081
Maternal factor SKN-1 affects SCN8A
| 1
Maternal factor SKN-1 activates SCN8A. 1 / 1
| 1
reach
"In the nematode, Caenorhabditis elegans, the endoderm (gut) is generated from a single embryonic precursor, E. Gut is specified by the maternal factor SKN-1, which activates the MED --> END-1,3 --> ELT-2,7 cascade of GATA transcription factors."
31740453
Lurasidone affects SCN8A
| 1
Lurasidone inhibits SCN8A. 1 / 1
| 1
reach
"Secondly, the novel antipsychotic lurasidone also impaired PA performance (MED 10mg/kp, i.p.)."
24599316
Ketamine affects SCN8A
| 1
Ketamine activates SCN8A. 1 / 1
| 1
reach
"Twenty bitches pretreated with levomedetomidine and buprenorphine were anesthetized with 5 mg * kg (-1) ketamine and 0.2 mg * kg (-1) midazolam i.v. Continuous infusion of 0.4 mg * kg (-1) * h (-1) midazolam and 20 mg * kg (-1) * h (-1) ketamine was initiated in combination with DEX (n = 10) : 20 microg * kg (-1) * h (-1) dexmedetomidine or MED (n = 10) : 30 microg * kg (-1) * h (-1) medetomidine over 30 minutes."
20305886
Imipramine affects SCN8A
| 1
Imipramine inhibits SCN8A. 1 / 1
| 1
reach
"In the modified forced swim test in rats, imipramine (used as a positive control) decreased immobility (MED 40 mg/kg) and increased the duration of escape oriented (climbing and diving; MED 20 mg/kg) behaviors."
16630709
Hsa-miR-8485 affects SCN8A
1 |
Transcriptionally active hsa-miR-8485 decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-8064 affects SCN8A
1 |
Transcriptionally active hsa-miR-8064 decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6837-3p affects SCN8A
1 |
Transcriptionally active hsa-miR-6837-3p decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6754-3p affects SCN8A
1 |
Transcriptionally active hsa-miR-6754-3p decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4262 affects SCN8A
1 |
Transcriptionally active hsa-miR-4262 decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-412-3p affects SCN8A
1 |
Transcriptionally active hsa-miR-412-3p decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-377-3p affects SCN8A
1 |
Transcriptionally active hsa-miR-377-3p decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-362-3p affects SCN8A
1 |
Transcriptionally active hsa-miR-362-3p decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-329-3p affects SCN8A
1 |
Transcriptionally active hsa-miR-329-3p decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-181d-5p affects SCN8A
1 |
Transcriptionally active hsa-miR-181d-5p decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-181c-5p affects SCN8A
1 |
Transcriptionally active hsa-miR-181c-5p decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-181b-5p affects SCN8A
1 |
Transcriptionally active hsa-miR-181b-5p decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-181a-5p affects SCN8A
1 |
Transcriptionally active hsa-miR-181a-5p decreases the amount of SCN8A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Gate affects SCN8A
| 1
Gate inhibits SCN8A. 1 / 1
| 1
reach
"A total of seven unique epilepsy variants have been observed within the SCN8A inactivation gate, including the recurrent p.E1483K inherited missense variant."
27875746
Follow-up 2 affects SCN8A
| 1
Follow-up 2 activates SCN8A. 1 / 1
| 1
reach
"Preexposure of hairless mice to several sub-MED levels of simulated solar radiation (SSR) specifically suppresses induction of 24-h ODC by a follow-up 2 x MED of SSR."
2302717
Fentanyl affects SCN8A
| 1
Fentanyl inhibits SCN8A. 1 / 1
| 1
reach
"The combined i.m. administration of fentanyl with IEM-1460 and spermine in above mentioned threshold doses leads to decrease of MED fentanyl in the combination with IEM-1460 in 150 times, and MED fentanyl in the combination with spermine -- in 15 times."
25464766
DT8 affects SCN8A
| 1
DT8 activates SCN8A. 1 / 1
| 1
reach
"Briggs et al. 7 reported that missense mutations in T6, T7, and T8 and in-frame deletions in TSP3D preferentially cause PSACH rather than MED."
29899997
Carbamazepine affects SCN8A
| 1
Carbamazepine activates SCN8A. 1 / 1
| 1
reach
"We studied the effects of 0.5 mg/kg IV atracurium in 53 neurosurgical patients : 21 nonepileptic patients receiving no anticonvulsant therapy (MED = 0); 14 epileptic patients treated with carbamazepine for years (MED = 1); and 18 epileptic patients treated with carbamazepine plus either phenytoin or valproic acid for years (MED = 2)."
2240640
C. affects SCN8A
| 1
C. activates SCN8A. 1 / 1
| 1
reach
"For example, mutations in eight of the nine codons are associated with MED (n = 13 cases), whereas (c. 1229G> A p. (Cys410Tyr)) appears to cause the borderline phenotype of MED or mild PSACH (n = 3)."
24595329
BetA1 affects SCN8A
| 1
BetA1 activates SCN8A. 1 / 1
| 1
reach
"Beta1 mediated neurite outgrowth is abrogated in Scn8a null cerebellar granule neurons, suggesting that the mechanism requires Na + current carried by Na v 1.6."
22007171
Base affects SCN8A
| 1
Base activates SCN8A. 1 / 1
| 1
reach
"Contrary to the mild phenotype MATN3 null mice displayed, mutation of a single base, however, could cause MED."
22270056
Ataxia3 mutant affects SCN8A
| 1
Ataxia3 mutant activates SCN8A. 1 / 1
| 1
reach
"The failure of the ataxia3 mutant to rescue the motor abnormalities and lethality of a null allele of Scn8a, together with the phenotypic similarity of ataxia3 to Scn8a mutants and the genetic mapping of ataxia3 near Scn8a, strongly support the identification of Nav1.6-S21P as the causal mutation in ataxia3 mice."
19261867
Astemizole affects SCN8A
| 1
Astemizole inhibits SCN8A. 1 / 1
| 1
reach
"The PPD antihistamines, namely terfenadine and astemizole, inhibited cough (MED 30 and 10 mg/kg p.o.) without sedative effects."
9691225
Amiodarone affects SCN8A
| 1
Amiodarone inhibits SCN8A. 1 / 1
| 1
reach
"Amiodarone and its active metabolite, desethylamiodarone, cause decrease of MED (minimal erythema dose) in the range of ultraviolet radiation type A (UV-A 320-400 nm), which can reach up to 50% of the correct values."
25413691
AlphaT affects SCN8A
| 1
AlphaT activates SCN8A. 1 / 1
| 1
reach
"AlphaT is also believed to be photoprotective as multiple studies have shown that alphaT in combination with vitamin C supplementation increases the MED [XREF_BIBR]."
29411317
Adrenoceptor affects SCN8A
| 1
Adrenoceptor inhibits SCN8A. 1 / 1
| 1
reach
"Simultaneous administration of the specific alpha-2 adrenoceptor antagonist, atipamezole (1 mg/kg), effectively inhibited the behavioral and most of the neurochemical actions of d MED (100 micrograms/kg)."
1682487
Acetic acid affects SCN8A
| 1
Acetic acid activates SCN8A. 1 / 1
| 1
reach
"Direct, naloxone-reversible analgesic effects of SCH 34826 were demonstrated in the mouse low temperature hot-plate test (MED = 30 mg/kg p.o.), the mouse acetic acid induced writhing test (MED = 30 mg/kg p.o.), the rat stress induced analgesia test (MED = 10 mg/kg p.o.) and the modified rat yeast-paw test (MED = 100 mg/kg p.o.)."
3164388
Ubx affects SCN8A
| 1
SCN8A binds Ubx. 1 / 1
| 1
reach
"Nonetheless, it will be of interest to determine whether Groucho can play a role in blocking MED and Ubx interactions that could provide an economical means for distinguishing gene activation from repression."
24786462
UMOD affects SCN8A
| 1
UMOD activates SCN8A. 1 / 1
| 1
reach
"At 15 days postpartum, both THP and THDOC enhanced the density of binding sites in MED with maximal increases by 485 or 462% of the control determined in the absence of steroids."
8829922
TLE5 affects SCN8A
| 1
SCN8A binds TLE5. 1 / 1
| 1
sparser
"We report here two illustrative cases and show the association of de novo SCN8A variants and AES."
32040247
THDOC affects SCN8A
| 1
THDOC activates SCN8A. 1 / 1
| 1
reach
"At 15 days postpartum, both THP and THDOC enhanced the density of binding sites in MED with maximal increases by 485 or 462% of the control determined in the absence of steroids."
8829922
TGFB1 affects SCN8A
| 1
TGFB1 inhibits SCN8A. 1 / 1
| 1
reach
"The inability of TGF-beta1 to rescue the attenuation of the chondrogenic marker aggrecan in the MED and SEMD expressing cells suggests that TGF-beta1 is not effective in restoring the normal chondrogenic phenotype in mutant chondroprogenitor cells."
25196597
TBP affects SCN8A
| 1
SCN8A binds TBP. 1 / 1
| 1
reach
"Here we have used RNA interference (RNAi) in Drosophila cells to selectively deplete subunits of the MED and TFIID complexes to dissect the contribution of each of these complexes in modulating activated transcription."
16751183
TAT-SOD cream 1 h affects SCN8A
| 1
TAT-SOD cream 1 h activates SCN8A. 1 / 1
| 1
reach
"Thus, the topical application of TAT-SOD cream 1 h prior to UVB radiation promoted a mean MED increase of 36.6 +/- 18.4% (p = 0.013 < 0.05) in 10 subjects, indicating a suppressive effect of TAT-SOD upon UVB induced erythema formation.The mean erythema readings at 10 incremental UVB doses from all 10 subjects are presented in Fig. 4 B. No significant erythema response was detected from 38 to 95 mJ/cm 2."
27460952
Sun affects SCN8A
| 1
Sun activates SCN8A. 1 / 1
| 1
reach
"Sun exposure has been postulated to increase MED."
29953669
Stress affects SCN8A
| 1
Stress activates SCN8A. 1 / 1
| 1
reach
"Stress also increased the percentage of Scn8a med/+ mice having seizures lasting longer than 15 min, whereas acute stress did not affect seizure duration in WT mice (XREF_FIG)."
24138934
ST8SIA2 affects SCN8A
| 1
SCN8A binds ST8SIA2. 1 / 1
| 1
reach
"It is known that SCN1A (Smith et al., 1998), SCN2A (Noda et al., 1986; Suzuki et al., 1988; Smith et al., 1998), SCN3A (Suzuki et al., 1988), and SCN8A (Smith et al., 1998) alpha subunits bind tetrodotoxin and STX with comparable affinities."
10827969
SSR504734 affects SCN8A
| 1
SSR504734 activates SCN8A. 1 / 1
| 1
reach
"SSR504734 prevented ketamine induced metabolic activation in mice limbic areas and reversed MK-801-induced hyperactivity and increase in EEG spectral energy in mice and rats, respectively (MED : 10-30 mg/kg i.p.)."
15956994
SSR180711 affects SCN8A
| 1
SSR180711 inhibits SCN8A. 1 / 1
| 1
reach
"SSR180711 also reversed (MED : 0.3 mg/kg) MK-801-induced deficits in retention of episodic memory in rats (object recognition)."
16936709
SHR affects SCN8A
| 1
SHR inhibits SCN8A. 1 / 1
| 1
reach
"Thus, an animal model of primary hypertension (SHR) manifested diminished brain synaptic PMCA activity and reduced MED for several volatile anesthetics."
7746091
SH3PXD2A affects SCN8A
| 1
SH3PXD2A activates SCN8A. 1 / 1
| 1
reach
"The mean MED increased from 19.8 to 33.8 mJ/cm 2 by dietary fish oil."
30061538
SERPINA5 affects SCN8A
| 1
SERPINA5 activates SCN8A. 1 / 1
| 1
reach
"Compared to MED, significantly lower mortality was observed in patients treated with PCI [adjusted hazard ratio (AHR) : 0.83, 95% confidence interval (CI) : 0.76 - 0.92, p = 0.0002], CABG (AHR : 0.56, CI : 0.51 - 0.62, p < 0.0001), and CABG+MVRR (AHR : 0.69, CI : 0.57 - 0.82, p < 0.0001)."
24744275
SCR affects SCN8A
| 1
SCR activates SCN8A. 1 / 1
| 1
reach
"Our analysis of a Drosophila skuld and Med13 mutation isolated by dose sensitive genetic interactions with homeotic proboscipedia (pb) and Sex combs reduced (Scr) genes led us to view MED as a Hox co-factor XREF_BIBR."
24786462
SCN8A affects very-low-density lipoprotein
| 1
SCN8A inhibits very-low-density lipoprotein. 1 / 1
| 1
reach
"The MED diet additionally decreased the larger subclasses of VLDL, several related VLDL fractions, VLDL-triglycerides, and serum-triglycerides (FDR p < 0.05)."
30725537
SCN8A affects vdh
| 1
SCN8A inhibits vdh. 1 / 1
| 1
reach
"The mechanism of MED inhibition of cytochrome P-450 is unknown."
1361312
SCN8A affects tridecane
| 1
Tridecane binds SCN8A. 1 / 1
| 1
reach
"The hazard ratio estimating the association between higher MED and TRD remained non significant after adding pain variables in model 3 (HR = 1.07; 95% CI :0.88 -1.30)."
27497660
SCN8A affects triacetylcellulose
| 1
SCN8A activates triacetylcellulose. 1 / 1
| 1
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"MeD significantly increased serum TAC (P < 0.001)."
32319358
SCN8A affects thromboxane receptors
| 1
SCN8A inhibits thromboxane receptors. 1 / 1
| 1
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"In summary, MED 27 dually inhibits both thromboxane synthase and thromboxane receptors."
8821515
SCN8A affects thromboxane
| 1
SCN8A inhibits thromboxane. 1 / 1
| 1
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"In summary, MED 27 dually inhibits both thromboxane synthase and thromboxane receptors."
8821515
SCN8A affects tetrodotoxin
| 1
Tetrodotoxin binds SCN8A. 1 / 1
| 1
reach
"It is known that SCN1A (Smith et al., 1998), SCN2A (Noda et al., 1986; Suzuki et al., 1988; Smith et al., 1998), SCN3A (Suzuki et al., 1988), and SCN8A (Smith et al., 1998) alpha subunits bind tetrodotoxin and STX with comparable affinities."
10827969
SCN8A affects squalene
| 1
SCN8A decreases the amount of squalene. 1 / 1
| 1
reach
"Diunsaturated and monounsaturated fatty acids as well as cholesterol were unaffected even following 10 MED UV exposures, which produced a 26% loss of squalene."
12069113
SCN8A affects salicylic acid
| 1
SCN8A activates salicylic acid. 1 / 1
| 1
reach
"Survival was increased in mice exposed to 0.6 MED of SSL and treated with 2% and 4% salicylic acid compared to mice treated with 0.6 MED and treated only with the vehicle."
21921960
SCN8A affects pyraclofos
| 1
SCN8A activates pyraclofos. 1 / 1
| 1
reach
"We observed SWD in mice carrying three alleles : Scn8a 8 J, a new allele with a non conservative amino acid substitution in the pore region of the channel and the well characterized mutations Scn8a med, a null allele, and Scn8a med-jo, a missense mutation in an intracellular linker that causes altered voltage dependence."
19254928
SCN8A affects propofol
| 1
SCN8A inhibits propofol. 1 / 1
| 1
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"Intramuscular MED doses of 5 and 10 microg kg (-1) reduced the propofol and isoflurane requirements for induction and maintenance of anaesthesia respectively."
16412127
SCN8A affects polymerase
| 1
SCN8A binds polymerase. 1 / 1
| 1
reach
"The phosphorylation status of the highly repetitive heptads in the carboxyl (C)-terminal domain (CTD) of the largest PolII subunit Rpb1 is thought to play a critical role in orchestrating the interaction between the yeast polymerase and MED."
18515835
SCN8A affects pigeon Compound ICTO*(nM) MED+(mg/kg) 1
| 1
SCN8A inhibits pigeon Compound ICTO*(nM) MED+(mg/kg) 1. 1 / 1
| 1
reach
"Potency of compounds to inhibit binding of pH] - PCP and the minimum effective doses (MED) to produce catalepsy in the pigeon Compound ICTO * (nM) MED+ (mg/kg) 1."
6095851
SCN8A affects p38
| 1
SCN8A phosphorylates p38. 1 / 1
| 1
reach
"We previously reported that in human sun protected skin, 4 MED of UV resulted in the phosphorylation of MAPKAPK2, CREB, c-JUN, p38, GSK-3b and p53 leading to markedly increased levels of c-FOS, COX-2 and apoptosis in the epidermal cells."
26031292
SCN8A affects oxidative phosphorylation
| 1
SCN8A inhibits oxidative phosphorylation. 1 / 1
| 1
reach
"Consumption of the MUFA and MED diets, compared with the SFA diet, decreased the expression of oxidative phosphorylation (OXPHOS) genes, plasma connective tissue growth factor, and apoB concentrations."
22623392
SCN8A affects nitric oxide
| 1
SCN8A inhibits nitric oxide. 1 / 1
| 1
reach
"LoD and MeD selenite significantly reduced the TNFalpha induced GAG release (by 83, 55%, respectively), NO production (by 59, 40%, respectively), and apoptosis (by 68, 39%, respectively)."
27783214
SCN8A affects miR-30b
| 1
SCN8A activates miR-30b. 1 / 1
| 1
reach
"Using TargetScan and miRanda predictive software, we discovered that Scn8a was a major target of miR-30b."
31054938
SCN8A affects malonaldehyde
| 1
SCN8A increases the amount of malonaldehyde. 1 / 1
| 1
reach
"The presence of additional O 2 in the air mixture did not affect the MDA content (115 +/-21.6%) as compared to untreated or air treated SC.However, 0.5 MED of SSUV significantly increased MDA levels as compared to no treatment (P < 0.001) or air (P < 0.001) or air plus O 2 treatment (P < 0.001)."
10648834
SCN8A affects kainic acid
| 1
SCN8A activates kainic acid. 1 / 1
| 1
reach
"We have previously demonstrated that Scn8a (med) and Scn8a (med-jo) mice carrying mutations in the Scn8a gene display increased resistance to flurothyl and kainic acid induced seizures; however, they also exhibit spontaneous absence seizures."
26410685
SCN8A affects isoflurane
| 1
SCN8A inhibits isoflurane. 1 / 1
| 1
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"Intramuscular MED doses of 5 and 10 microg kg (-1) reduced the propofol and isoflurane requirements for induction and maintenance of anaesthesia respectively."
16412127
SCN8A affects iron atom
| 1
SCN8A inhibits iron atom. 1 / 1
| 1
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"In humans, a green MED low-meat diet does not impair iron homeostasis."
30915471
SCN8A affects inositol
| 1
SCN8A activates inositol. 1 / 1
| 1
reach
"Effect of pilocarpine In the presence of lithium (10 mEq/kg) there was a dose dependent accumulation of inositol monophos- phates stimulated by the muscarinic receptor agonist pilocarpine (MED 10 mg/kg), with a maximum re-.5 o4 o ~."
8088372
SCN8A affects immune response
| 1
SCN8A inhibits immune response. 1 / 1
| 1
reach
"It is plausible that PKC delta promotes UV induced apoptosis in cooperation with other protein kinases and cell death signal pathways.UVB at high doses and even such a low level as one minimal erythema dose (MED) can impair host immune surveillance for skin cancers in rodents possibly by modulating the expression of co-stimulatory function of epidermal Langerhans cells (LCs) and lymphocytes."
12821280
SCN8A affects imidazolide
| 1
SCN8A inhibits imidazolide. 1 / 1
| 1
reach
"To investigate the cardiovascular and sedation reversal effects of IM administration of atipamezole (AA) in dogs treated with medetomidine hydrochloride (MED) or MED and vatinoxan (MK-467)."
31556714
SCN8A affects hydrogen chloride
| 1
SCN8A activates hydrogen chloride. 1 / 1
| 1
reach
"In addition, MED level (156mg/Kg body weight) increased the CL size and circulating P 4 during the luteal phase."
29859703
SCN8A affects homeostatic process
| 1
SCN8A inhibits homeostatic process. 1 / 1
| 1
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"In humans, a green MED low-meat diet does not impair iron homeostasis."
30915471
SCN8A affects hard-margin
| 1
SCN8A activates hard-margin. 1 / 1
| 1
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"Maximum entropy discrimination (MED) is a general framework for discriminative estimation based on maximum entropy and maximum margin principles, and can produce hard-margin support vector machines under some assumptions."
26111403
SCN8A affects functions
| 1
SCN8A inhibits functions. 1 / 1
| 1
sparser
"Tetrodotoxin or synthetic small interfering RNA targeted for SCN8A and SCN9A inhibited metastatic functions (endocytosis and invasion), but failed to inhibit proliferation in PC-3 cells."
19154441
SCN8A affects extracellular matrix
| 1
SCN8A activates extracellular matrix. 1 / 1
| 1
reach
"In contrast, COMP-null mice show no differences in collagen fibril diameter and these data therefore suggest that PSACH and MED causing mutations in matrilin-3 and COMP can cause changes in the ultra-structure of the cartilage ECM through antimorphic mechanisms."
23951406
SCN8A affects eukaryotic initiation factor 2
| 1
SCN8A leads to the phosphorylation of eukaryotic initiation factor 2. 1 / 1
| 1
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"Moreover, phosphorylation of eukaryotic initiation factor 2 (eIF2alpha) was enhanced by MED and enalapril treatment significantly suppressed MED induced increase of phosphorylation of eIF2alpha (XREF_FIG)."
26640794
SCN8A affects epithelial to mesenchymal transition
| 1
SCN8A activates epithelial to mesenchymal transition. 1 / 1
| 1
reach
"We therefore asked whether MED 12 KD indeed induces an EMT like process and whether the processes induced by MED12 KD are likewise associated with poor prognosis in CRC."
23178117
SCN8A affects dinitrogen
| 1
SCN8A inhibits dinitrogen. 1 / 1
| 1
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"Taken together, this indicates that MED genotypes may have already reduced the capacity of major carbon and nitrogen metabolism at 3 d after stress establishment, which does not occur to the same extent in GER genotypes."
28338908
SCN8A affects diOC18(3) dye
| 1
SCN8A activates diOC18(3) dye. 1 / 1
| 1
reach
"Additionally, the minimal effective dose (MED) of MB12066 in a diet induced obese (DIO) model rat was 5 mg/kg/day."
29158665
SCN8A affects corticosterone
| 1
SCN8A decreases the amount of corticosterone. 1 / 1
| 1
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"Dysfunction of the Scn8a voltage gated sodium channel alters sleep architecture, reduces diurnal corticosterone levels, and enhances spatial memory."
20353942
SCN8A affects cocaine
| 1
SCN8A activates cocaine. 1 / 1
| 1
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"The tubing was attached to a syringe that was driven by either a Harvard Apparatus model 22 syringe pump or a MED Associates syringe pump that infused the cocaine solution at a rate of 3.19 ml/min."
11841897
SCN8A affects cephradine
| 1
SCN8A activates cephradine. 1 / 1
| 1
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"Table 5 Tensile strength and cross-sectional area of ovine digital extensor tendons excised at surgery and collected at necropsy Left (operated) (mean SD) Right (control) (mean SD) MED LED CED MED LED CED Study I Type I xenografts n = 12 Time zero (surgery) UTL (N) 361 36 * 388 67t Area (mm2) 5.3.7 * 4.6 0.5 ^ n 12 12 12 weeks (necropsy) UTL (N) 254 37 Area (mm2) 3.7 0.4 n 12 324 44 * 4.2 0.6 * 12 327 36t 3.7 0.3 t 12 217 6 2.8.3 12 Study II Type II xenograftsn = 5 Time zero (surgery) UTL (N) 225 49 212 0 Area (mm2) 4.7.5 5.6.9 n 5 5 12 weeks (necropsy) UTL (N) 226 6 254 1 228 1 234 1 Area (mm2) 4.0.3 4.8.6 5.1.3 4.1.0 n 5 555 nd ' Differences between zero and 12 week values are significant (p < 0.05)."
9031723
SCN8A affects cell cycle
| 1
SCN8A activates cell cycle. 1 / 1
| 1
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"MED could induce cell cycle arrest at G2/M in HeLa cells."
20970330
SCN8A affects calciol
| 1
SCN8A activates calciol. 1 / 1
| 1
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"XREF_BIBR, XREF_BIBR Estimates vary, but around half of MED of direct sunlight on arms and legs can produce the equivalent to around 3,000 IU of vitamin D3."
25761256
SCN8A affects c-JUN
| 1
SCN8A phosphorylates c-JUN. 1 / 1
| 1
reach
"We previously reported that in human sun protected skin, 4 MED of UV resulted in the phosphorylation of MAPKAPK2, CREB, c-JUN, p38, GSK-3b and p53 leading to markedly increased levels of c-FOS, COX-2 and apoptosis in the epidermal cells."
26031292
SCN8A affects brief Adlerian psychodynamic psychotherapy
| 1
SCN8A activates brief Adlerian psychodynamic psychotherapy. 1 / 1
| 1
reach
"This study compared results among subjects treated with brief Adlerian psychodynamic psychotherapy (B-APP), those treated with medication (MED), or those who experienced combined treatment (COM)."
17900875
SCN8A affects adiponectin receptor
| 1
SCN8A activates adiponectin receptor. 1 / 1
| 1
reach
"Chronic ethanol ingestion led to more significant decreases in the hepatic expression of the adipoR1 and adipoR2 genes than in the ND mice, and MED feeding significantly restored these ethanol induced changes in the adiponectin receptor genes."
22013387
SCN8A affects Wnt
| 1
SCN8A activates Wnt. 1 / 1
| 1
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"The fly MED12 and MED 13 homologs, kohtalo and skuld, respectively activate Wnt and beta-catenin target genes through direct interaction with the Wnt pathway component Pygopus."
24504440
SCN8A affects WT
| 1
SCN8A activates WT. 1 / 1
| 1
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"Scn8a RH/+ / Scn1a RH/+ males were then crossed to N10 Scn1a RH/+ females to produce WT, Scn8a RH/+, Scn1a RH/+, Scn8a RH/+ / Scn1a RH/+, Scn1a RH/RH, and Scn8a RH/+ / Scn1a RH/RH offspring."
26410685
SCN8A affects WIPF2
| 1
SCN8A activates WIPF2. 1 / 1
| 1
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"Silicone (MED 4211, NuSil Technology) was applied to the backside of the array and the wire bundle to secure the bond connections, increase the strength of the wire buddle, and further protect the array from handling forces and fluid ingress."
24658358
SCN8A affects Val-Ile
| 1
SCN8A activates Val-Ile. 1 / 1
| 1
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"MED produced a depression of VI performance which was greatest at low levels of deprivation."
565058
SCN8A affects VLDL-triglycerides
| 1
SCN8A inhibits VLDL-triglycerides. 1 / 1
| 1
reach
"The MED diet additionally decreased the larger subclasses of VLDL, several related VLDL fractions, VLDL-triglycerides, and serum-triglycerides (FDR p < 0.05)."
30725537
SCN8A affects Ubx
| 1
SCN8A binds Ubx. 1 / 1
| 1
reach
"Nonetheless, it will be of interest to determine whether Groucho can play a role in blocking MED and Ubx interactions that could provide an economical means for distinguishing gene activation from repression."
24786462
SCN8A affects TLR4
| 1
SCN8A leads to the dephosphorylation of TLR4. 1 / 1
| 1
reach
"Moreover, MED suppressed NF-kappaB activation by blocking IkappaB-alpha (IkappaB-alpha) degradation and inhibited the phosphorylation of ERK 1/2 and toll like receptor 4 (TLR4) expression, but had no effect on the phosphorylation of JNK, and p38."
24447679
SCN8A affects TLE5
| 1
SCN8A binds TLE5. 1 / 1
| 1
sparser
"We report here two illustrative cases and show the association of de novo SCN8A variants and AES."
32040247
SCN8A affects TGFB1
| 1
SCN8A inhibits TGFB1. 1 / 1
| 1
reach
"MED significantly inhibited LPS induced production of pro inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon-gamma (INF-gamma), and nitric oxide (NO), whereas it increased anti-inflammatory interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1) production in BV2 microglia in a concentration dependent manner without causing cytotoxicity."
24447679
SCN8A affects TBP
| 1
SCN8A binds TBP. 1 / 1
| 1
reach
"Here we have used RNA interference (RNAi) in Drosophila cells to selectively deplete subunits of the MED and TFIID complexes to dissect the contribution of each of these complexes in modulating activated transcription."
16751183
SCN8A affects Ser-Ala
| 1
SCN8A inhibits Ser-Ala. 1 / 1
| 1
reach
"A mutation in another MED subunit, MED 15 (isolated in a screen for non-recognition-of-the SA analog, BTH, nrb4), also attenuates SAR and SA responsiveness."
25918514
SCN8A affects Scn1a-R1648H
| 1
SCN8A-R1627H activates Scn1a-R1648H. 1 / 1
| 1
reach
"The Scn8a R1627H mutation increases the lifespan and seizure thresholds of Scn1a-R1648H GEFS+ mice."
26410685
SCN8A affects SUDEP
| 1
SCN8A-N1768D activates SUDEP. 1 / 1
| 1
reach
"We now report that the N1768D mutation of SCN8A is sufficient to induce seizures and SUDEP in knock-in mice."
25227913
SCN8A affects ST8SIA2
| 1
SCN8A binds ST8SIA2. 1 / 1
| 1
reach
"It is known that SCN1A (Smith et al., 1998), SCN2A (Noda et al., 1986; Suzuki et al., 1988; Smith et al., 1998), SCN3A (Suzuki et al., 1988), and SCN8A (Smith et al., 1998) alpha subunits bind tetrodotoxin and STX with comparable affinities."
10827969
SCN8A affects SIRT1
| 1
SCN8A increases the amount of SIRT1. 1 / 1
| 1
reach
"Similarly, the MED feeding significantly reversed the marked decreases in the mRNA levels of the hepatic SIRT1 and PGC1alpha, which were induced by ethanol feeding."
22013387
SCN8A affects SH2B2
| 1
SCN8A activates SH2B2. 1 / 1
| 1
reach
"We found that RT cells of Scn8a + /- mice produced fewer APs in both tonic and burst firing modes (XREF_SUPPLEMENTARY)."
28238546
SCN8A affects SERPINE1
| 1
SCN8A increases the amount of SERPINE1. 1 / 1
| 1
reach
"On the contrary, a single MED significantly enhanced mRNA levels of interleukin-1alpha (IL-1alpha), IL-1beta (P < 0.02) and plasminogen activator inhibitor-1 (P < 0.05)."
15115299
SCN8A affects SERPINB1
| 1
SCN8A activates SERPINB1. 1 / 1
| 1
reach
"Lim et al. demonstrated that 2.5 MED of UVB irradiation increased skin EI and reached the highest value on day 2 after irradiation, whilst the skin MI was obviously increased on day 3 [XREF_BIBR]."
27478534
SCN8A affects SEC14L2
| 1
SCN8A activates SEC14L2. 1 / 1
| 1
reach
"3 MED is readily achievable by skin types I/II in the UK after 1-2-h exposure to summer sunlight, allowing an SPF 10 user to receive 0.3 MED (3 MED/10)."
10662801
SCN8A affects SEBT
| 1
SCN8A activates SEBT. 1 / 1
| 1
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"The MED direction of the SEBT was significantly positively correlated with hip internal rotator tightness and hamstrings tightness and significantly negatively correlated with gastrocnemius tightness."
24926127
SCN8A affects SCNM1
| 1
SCN8A binds SCNM1. 1 / 1
| 1
sparser
"Although the genetic interaction between Scnm1 and Scn8a splicing has been studied in detail, the mechanism of SCNM1 function as a splicing regulator is less clear."
27094079
SCN8A affects SCD
| 1
SCN8A activates SCD. 1 / 1
| 1
reach
"XREF_BIBR The results from this study show that the MED level of oil supplementation (4.94% total fatty acids in diet) up-regulates gene expression of key lipogenic enzymes (FASN, SCD, or LPL) but that as oil supplementation reaches HI level (7.99% total fatty acids in diet) genes encoding lipogenic enzymes responsible for de novo fatty acid synthesis and MUFA synthesis are down-regulated."
21072324
SCN8A affects SAR
| 1
SCN8A inhibits SAR. 1 / 1
| 1
reach
"A mutation in another MED subunit, MED 15 (isolated in a screen for non-recognition-of-the SA analog, BTH, nrb4), also attenuates SAR and SA responsiveness."
25918514
SCN8A affects RETN
| 1
SCN8A inhibits RETN. 1 / 1
| 1
reach
"The MED Diet Reduces Resistin Production."
29312949
SCN8A affects RB1
| 1
SCN8A inhibits RB1. 1 / 1
| 1
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"Among neuroleptics studied the minimal effective doses (MED) antagonizing AP hypothermia (APH) ranged from 0.006 (trifluperidol) to 0.5 mg/kg (chlorpromazine), while MED antagonizing PRB hypothermia (PRBH) ranged from 0.05 (trifluperidol and perphenazine) to 2.0 mg/kg (haloperidol)."
6104689
SCN8A affects Protease
| 1
SCN8A inhibits Protease. 1 / 1
| 1
reach
"After 20 min, the protease was inactivated by addition of 25 ml of A MED containing 2% (w/v) BSA and 40 Ng/ml phenylmethylsulfonylfluoride."
4075403
SCN8A affects Phe-Thr
| 1
SCN8A activates Phe-Thr. 1 / 1
| 1
reach
"XREF_FIG), suggesting that upregulation of Na V 1.2 in Scn8a -/- neurons could promote FT induced neuronal excitability."
29335582
SCN8A affects PUM2
| 1
SCN8A activates PUM2. 1 / 1
| 1
reach
"For known Pum2 targets such as Scn1a and Scn8a, we did not detect changes at the mRNA level in 5-month-old brains."
29046322
SCN8A affects PS
| 1
SCN8A inhibits PS. 1 / 1
| 1
reach
"Recordings from ND rats taken for 3 hr/day on 3 consecutive control days, on the drug day and on 5 post-drug days revealed that only the 5 mg/kg dose of MED failed to cause a significant reduction in PS compared to the pre-drug control levels."
4355678
SCN8A affects PRL
| 1
SCN8A inhibits PRL. 1 / 1
| 1
reach
"The depolarization induced PRL release was also inhibited, but the MED was 100-fold higher than the MED to inhibit basal PRL release."
1369597
SCN8A affects PPARGC1A
| 1
SCN8A increases the amount of PPARGC1A. 1 / 1
| 1
reach
"Similarly, the MED feeding significantly reversed the marked decreases in the mRNA levels of the hepatic SIRT1 and PGC1alpha, which were induced by ethanol feeding."
22013387
SCN8A affects PKD
| 1
SCN8A binds PKD. 1 / 1
| 1
reach
"SCN8A associated PKD like episodes."
28090678
SCN8A affects PIMREG
| 1
SCN8A inhibits PIMREG. 1 / 1
| 1
reach
"Both MED (at 15 microg/kg) and BTO (at 0.1 mg/kg) prevent postoperative pain in cats after ovariohysterectomy."
11884953
SCN8A affects PI3K
| 1
SCN8A activates PI3K. 1 / 1
| 1
reach
"We found that a single dose of 2-3 MED of SSL activated the PI3K and Akt signaling pathway with a small but statistically significant increase in cytoplasmic and nuclear staining of p-Akt at serine 473 (XREF_FIG, 1.4-fold increase at 5 hrs post SSL; p = 0.01)."
26031292
SCN8A affects PEMF
| 1
SCN8A activates PEMF. 1 / 1
| 1
reach
"MED induced PEMF treatment resulted in an immunomodulatory effect in MSCs as expressed by increased IL-10 secretion."
29572540
SCN8A affects PEAT
| 1
SCN8A activates PEAT. 1 / 1
| 1
reach
"The MED raising heart rate of the three PEAT, on the other hand, was about twice (SR 58375A and SR 58572A) to five (SR 58539B) times their ED50 for inhibition of colonic motility."
2566103
SCN8A affects PARP1
| 1
SCN8A leads to the ribosylation of PARP1. 1 / 1
| 1
reach
"Although erythematogenic, 4 MED UV exposure induced an excessive activation of the self-ADP-ribosylation of PARP in the vehicle pretreated skin of mice, as determined by Western blot analysis, pretreatment of the mouse skin with> = 10% BGP-15M-containing cream decreased the UV induced ADP ribosylation of PARP."
11911844
SCN8A affects P7-P8
| 1
SCN8A activates P7-P8. 1 / 1
| 1
reach
"Based on analysis of cells from mice with a Scn8a null mutation, Scn8a channels appear to contribute significantly to total sodium current in both in P10-P14 Purkinje cells (approximately 40%; [21]) and cultured P7-P8 spinal motoneurons (approximately 70% [K.D. Garcia, L.K. Sprunger, M.H. Meisler, K.G. Beam, The sodium channel Scn8a is the major contributor to the postnatal developmental increase of sodium current density in spinal motoneurons, J. Neurosci."
10592298
SCN8A affects OXT
| 1
SCN8A activates OXT. 1 / 1
| 1
reach
"As demonstrated here, however, the OT tables produced by OP and MED might sometimes not necessarily capture the same ecological information, and this was particularly notable when investigating the fine correspondences between OT abundance and sample mapping in ordination space."
25452747
SCN8A affects OMIM #614558
| 1
SCN8A activates OMIM #614558. 1 / 1
| 1
reach
"SCN8A encephalopathy is a newly defined EE caused by de novo mutations of the gene SCN8A encoding the sodium channel Na v 1.6 (OMIM # 614558)."
27270488
SCN8A affects ODC1
| 1
SCN8A activates ODC1. 1 / 1
| 1
reach
"Preexposure to a single 2 x MED of SSR specifically enhances induction of 24-h ODC induced by a second 2 x MED of SSR administered 48 h after the first."
2302717
SCN8A affects NTS
| 1
SCN8A inhibits NTS. 1 / 1
| 1
reach
"The present study revealed that the MED to reduce the infectivity of the Chinese NT strain and the American ME-49 and TS-2 strains of Toxoplasma cysts in mouse and pig tissues was 0.6 kGy."
8468140
SCN8A affects NK
| 1
SCN8A inhibits NK. 1 / 1
| 1
reach
"The maximum effective dose (MED) of mitomycin C or its derivative (M-83) suppressed NK activity significantly, and pretreatment with these anticancer agents enhanced the growth of the artificial pulmonary and liver metastases."
6736102
SCN8A affects NFKBIA
| 1
SCN8A leads to the deubiquitination of NFKBIA. 1 / 1
| 1
reach
"Indeed, we found that MED significantly blocked the ubiquitination of TRAF6 and IkappaBalpha (XREF_FIG and XREF_SUPPLEMENTARY) in HEK 293T cells without LPS treatment, indicating that MED can inhibit protein ubiquitination independently on TLR4 signaling."
22984582
SCN8A affects NFKB1
| 1
SCN8A decreases the amount of NFKB1. 1 / 1
| 1
reach
"The MED feeding significantly downregulated the expressions of the p50, p65, TNFalpha, IL-6, IFNalpha, IFNbeta, IL-12-p40, and CXCL2 genes compared to the ED mice (XREF_FIG)."
22013387
SCN8A affects NAV1
| 1
SCN8A binds NAV1. 1 / 1
| 1
sparser
"Mutations in human SCN8A , which encodes Nav1.6, are associated with cerebellar atrophy and ataxia ( xref )."
18930825
SCN8A affects MYC
| 1
SCN8A increases the amount of MYC. 1 / 1
| 1
reach
"Structural changes in ssDNA following Psi and FBP1 loading will modulate promoter architecture further to facilitate exit of the CDK8 module, thus maximising MED driven RNA Pol II activity and MYC transcription."
27207882
SCN8A affects MXD1
| 1
SCN8A binds MXD1. 1 / 1
| 1
reach
"We reasoned that some components of the EGFR signaling pathway may be transcriptional upregulated by the activated MAD and MED complex, which in turn activate EGFR signaling."
30992503
SCN8A affects MTOR
| 1
SCN8A activates MTOR. 1 / 1
| 1
reach
"An analysis of the Sicilian diet of centenarians from the Sicani Mountains and the eating habits of the inhabitants of Palermo showed that the low animal protein content and low glycemic index of the Sicilian MeD might directly modulate the insulin and IGF -1 and the mTOR pathways, which might be key pathways by which MeD exerts its beneficial effects in aging and longevity [XREF_BIBR]."
26783955
SCN8A affects MFI zeolite
| 1
SCN8A activates MFI zeolite. 1 / 1
| 1
reach
"Simulated and experimental MED powder data were produced using an MFI zeolite as a static spectator in which Xe, acting as the active species, is adsorbed and desorbed in a periodic manner."
26079296
SCN8A affects MEK
| 1
SCN8A activates MEK. 1 / 1
| 1
reach
"However, MED also induces the MEK and ERK pathway, which is classically considered to promote cell survival."
25014191
SCN8A affects MEAM1
| 1
SCN8A binds MEAM1. 1 / 1
| 1
reach
"We conducted laboratory experiments and field sampling to examine the effects of insecticide application on the competitive interactions between MEAM1 and MED."
23458717
SCN8A affects ME-49
| 1
SCN8A inhibits ME-49. 1 / 1
| 1
reach
"The present study revealed that the MED to reduce the infectivity of the Chinese NT strain and the American ME-49 and TS-2 strains of Toxoplasma cysts in mouse and pig tissues was 0.6 kGy."
8468140
SCN8A affects MAPKAPK2
| 1
SCN8A phosphorylates MAPKAPK2. 1 / 1
| 1
reach
"We previously reported that in human sun protected skin, 4 MED of UV resulted in the phosphorylation of MAPKAPK2, CREB, c-JUN, p38, GSK-3b and p53 leading to markedly increased levels of c-FOS, COX-2 and apoptosis in the epidermal cells."
26031292
SCN8A affects MAPK14
1 |
SCN8A binds MAPK14. 1 / 1
1 |
hprd
No evidence text available
16014723
SCN8A affects LPL
| 1
SCN8A activates LPL. 1 / 1
| 1
reach
"XREF_BIBR The results from this study show that the MED level of oil supplementation (4.94% total fatty acids in diet) up-regulates gene expression of key lipogenic enzymes (FASN, SCD, or LPL) but that as oil supplementation reaches HI level (7.99% total fatty acids in diet) genes encoding lipogenic enzymes responsible for de novo fatty acid synthesis and MUFA synthesis are down-regulated."
21072324
SCN8A affects LOS
| 1
SCN8A activates LOS. 1 / 1
| 1
reach
"It was found that Pre-operative opioids> 12 MED does increase LOS."
32021024
SCN8A affects LDL
| 1
SCN8A inhibits LDL. 1 / 1
| 1
reach
"Both MUFA and MED diet decreased exactly the same fractions of LDL, including particle number, lipid, phospholipid and free cholesterol fraction (FDR p < 0.05)."
30725537
SCN8A affects L-ascorbic acid
| 1
L-ascorbic acid binds SCN8A. 1 / 1
| 1
reach
"The inverse association between vitamin C and MED was against our hypothesis."
14506481
SCN8A affects KHDRBS3
| 1
SCN8A binds KHDRBS3. 1 / 1
| 1
sparser
"Such effects may well be related to function in the pyramidal neuron AIS, as Na V 1.6 expression is significantly higher in epileptic mice deficient for CELF4, an RNA binding protein that binds to Scn8a mRNA [ xref ]."
24657915
SCN8A affects Ile-His
| 1
SCN8A inhibits Ile-His. 1 / 1
| 1
reach
"The objective of this study was to determine if adrenal medullectomy (MED) prevents metabolic dysfunction in IH."
25179887
SCN8A affects IOP
| 1
SCN8A inhibits IOP. 1 / 1
| 1
reach
"These results show that MED lowers IOP in part, by interacting with alpha-2 adrenoceptors located on sympathetic nerve endings."
1680113
SCN8A affects IL1A
| 1
SCN8A increases the amount of IL1A. 1 / 1
| 1
reach
"On the contrary, a single MED significantly enhanced mRNA levels of interleukin-1alpha (IL-1alpha), IL-1beta (P < 0.02) and plasminogen activator inhibitor-1 (P < 0.05)."
15115299
SCN8A affects IL-12-p40
| 1
SCN8A decreases the amount of IL-12-p40. 1 / 1
| 1
reach
"The MED feeding significantly downregulated the expressions of the p50, p65, TNFalpha, IL-6, IFNalpha, IFNbeta, IL-12-p40, and CXCL2 genes compared to the ED mice (XREF_FIG)."
22013387
SCN8A affects IGF2
| 1
SCN8A decreases the amount of IGF2. 1 / 1
| 1
reach
"Treatment of PZp53 MED cells with anti-Igf1R antibody can therefore block the effects of even superphysiologic levels of Igf2."
18974121
SCN8A affects IGF1
| 1
SCN8A activates IGF1. 1 / 1
| 1
reach
"An analysis of the Sicilian diet of centenarians from the Sicani Mountains and the eating habits of the inhabitants of Palermo showed that the low animal protein content and low glycemic index of the Sicilian MeD might directly modulate the insulin and IGF -1 and the mTOR pathways, which might be key pathways by which MeD exerts its beneficial effects in aging and longevity [XREF_BIBR]."
26783955
SCN8A affects IFNB1
| 1
SCN8A decreases the amount of IFNB1. 1 / 1
| 1
reach
"The MED feeding significantly downregulated the expressions of the p50, p65, TNFalpha, IL-6, IFNalpha, IFNbeta, IL-12-p40, and CXCL2 genes compared to the ED mice (XREF_FIG)."
22013387
SCN8A affects IFNA
| 1
SCN8A decreases the amount of IFNA. 1 / 1
| 1
reach
"The MED feeding significantly downregulated the expressions of the p50, p65, TNFalpha, IL-6, IFNalpha, IFNbeta, IL-12-p40, and CXCL2 genes compared to the ED mice (XREF_FIG)."
22013387
SCN8A affects ID1
| 1
Mutated SCN8A binds ID1. 1 / 1
| 1
reach
"XREF_BIBR, reported a cohort of Chinese patients and identified five de novo SCN8A variants that stated to be the first reported in Chinese patients with epilepsy and ID/DD, in our cohort we identified a novel de novo SCN8A mutation associated with unclassified EEEs and moderate ID, thus enriching the relation between SCN8A variants and EIEE."
28387369
SCN8A affects Histone_H4
| 1
SCN8A leads to the acetylation of Histone_H4. 1 / 1
| 1
reach
"Considering the TNF-alpha-mediated regulation of the p-STAT3 activity, these studies suggested an enhanced interaction between p-STAT3 and p300, possibly mediated by TNF-alpha, in the Scn8a promoter region, which increased the histone H4 acetylation and facilitated the Nav1.6 expression in the rodents with L5-VRT."
30736806
SCN8A affects HSPA5
| 1
SCN8A inhibits HSPA5. 1 / 1
| 1
reach
"Finally, Annexin-PI staining of apoptotic cells revealed that MED inhibition of GRP78 leads to reduced osteoblast apoptosis and increased osteoblast survival."
27316719
SCN8A affects HSP90
| 1
SCN8A inhibits HSP90. 1 / 1
| 1
reach
"Mycoepoxydiene (MED) can inhibit Hsp90 function and induce apoptosis in cervical cancer cells."
25014191
SCN8A affects Gly-Gly-Ala
| 1
SCN8A inhibits Gly-Gly-Ala. 1 / 1
| 1
reach
"SCN8A forward 5 '-CTG GAG AAT GGA GGC ACA CAC-3 ', reverse 5 '-ACG CTG CTG CTT CTC CTT GTC-3 '; and beta-actin forward 5 '-CGT TGA CAT CCG TAA AGA CCT-3 ', reverse 5 '-TCA GGA GGA GCA ATG ATC TTG-3 '."
27013956
SCN8A affects GTF2H4
| 1
SCN8A activates GTF2H4. 1 / 1
| 1
reach
"MED will also bring TFIIH kinase activity into close proximity with the CTD of RNA Pol II, consistent with MED stimulating TFIIH dependent CTD phosphorylation and RNA Pol II promoter clearance."
27207882
SCN8A affects GSK3B
| 1
SCN8A phosphorylates GSK3B. 1 / 1
| 1
reach
"We previously reported that in human sun protected skin, 4 MED of UV resulted in the phosphorylation of MAPKAPK2, CREB, c-JUN, p38, GSK-3b and p53 leading to markedly increased levels of c-FOS, COX-2 and apoptosis in the epidermal cells."
26031292
SCN8A affects GSC
| 1
SCN8A inhibits GSC. 1 / 1
| 1
reach
"SCN8A, KCNB1, or GRIA3 knockdown reduces GSC viability."
28264064
SCN8A affects GNAO1
1 |
SCN8A binds GNAO1. 1 / 1
1 |
hprd
No evidence text available
10066808
SCN8A affects GLUL
| 1
SCN8A inhibits GLUL. 1 / 1
| 1
reach
"Other GS components in cabbage, such as IBE, SIN, GBC, and 4OH, were significantly decreased by both MEAM1 and MED."
28861220
SCN8A affects GFAP
| 1
SCN8A decreases the amount of GFAP. 1 / 1
| 1
reach
"Knockdown of Scn8a in the hippocampus reduces GFAP expression but not neuronal loss in the MTLE model."
29317669
SCN8A affects GCA
| 1
SCN8A inhibits GCA. 1 / 1
| 1
reach
"SCN8A forward 5 '-CTG GAG AAT GGA GGC ACA CAC-3 ', reverse 5 '-ACG CTG CTG CTT CTC CTT GTC-3 '; and beta-actin forward 5 '-CGT TGA CAT CCG TAA AGA CCT-3 ', reverse 5 '-TCA GGA GGA GCA ATG ATC TTG-3 '."
27013956
SCN8A affects GART
| 1
Mutated SCN8A activates GART. 1 / 1
| 1
reach
"Homozygous Nrcam and heterozygous Scn8a mutations synergized with both an Sh3tc2 mutation, modeling recessive demyelinating Charcot-Marie-Tooth type 4C, and mutations in Gars, modeling dominant axonal Charcot-Marie-Tooth type 2D."
28355569
SCN8A affects FUT2
| 1
SCN8A activates FUT2. 1 / 1
| 1
reach
"In addition, increased Scn8a mRNA and protein levels were also observed in the hippocampus 9 following systemic pilocarpine induced SE."
29317669
SCN8A affects FUBP1
| 1
SCN8A binds FUBP1. 1 / 1
| 1
reach
"Further studies are required to determine whether human FUBP1 also interacts with MED to modulate expression of the mammalian MYC oncogene."
28398229
SCN8A affects FSH
| 1
SCN8A inhibits FSH. 1 / 1
| 1
reach
"o 1-92 ++ + ++ The MED of a-IB-92 to suppress FSH release in vivo was approximately equal to that recently reported for 32K ainhibin (40 pmoles) (23)."
8015360
SCN8A affects FGF12
1 |
SCN8A binds FGF12. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN8A affects FGF11
1 |
SCN8A binds FGF11. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN8A affects FASP
| 1
SCN8A activates FASP. 1 / 1
| 1
reach
"The filter aided sample preparation (FASP) and the multiple enzyme digestion FASP (MED FASP) are one of the most effective proteomic methods for sample preparation."
29209155
SCN8A affects FASN
| 1
SCN8A activates FASN. 1 / 1
| 1
reach
"XREF_BIBR The results from this study show that the MED level of oil supplementation (4.94% total fatty acids in diet) up-regulates gene expression of key lipogenic enzymes (FASN, SCD, or LPL) but that as oil supplementation reaches HI level (7.99% total fatty acids in diet) genes encoding lipogenic enzymes responsible for de novo fatty acid synthesis and MUFA synthesis are down-regulated."
21072324
SCN8A affects ERVK-10
| 1
SCN8A activates ERVK-10. 1 / 1
| 1
reach
"Loss of Scn8a Impairs Intra-RT Inhibition but Not RT --> TC Inhibition."
28238546
SCN8A affects ERCC3
| 1
SCN8A activates ERCC3. 1 / 1
| 1
reach
"The MED complex interacts with the Pol II machinery to modulate transcription in all eukaryotes [XREF_BIBR, XREF_BIBR]."
28398229
SCN8A affects EIF2S1
| 1
SCN8A leads to the phosphorylation of EIF2S1. 1 / 1
| 1
reach
"Moreover, phosphorylation of eukaryotic initiation factor 2 (eIF2alpha) was enhanced by MED and enalapril treatment significantly suppressed MED induced increase of phosphorylation of eIF2alpha (XREF_FIG)."
26640794
SCN8A affects EIF2AK2
| 1
SCN8A leads to the phosphorylation of EIF2AK2. 1 / 1
| 1
reach
"In XREF_FIG, the results showed that MED significantly increased the phosphorylation of protein kinase R like endoplasmic reticulum kinase (PERK), which was inhibited by enalapril treatment."
26640794
SCN8A affects EIEE
| 1
Mutated SCN8A activates EIEE. 1 / 1
| 1
reach
"EIEE caused by mutation of SCN8A is designated EIEE13 (OMIM # 614558)."
26029160
SCN8A affects EE
| 1
Mutated SCN8A activates EE. 1 / 1
| 1
reach
"The authors showed that the functional effect of the mutation, an increase in persistent current, was consistent with a dominant, gain-of-function phenotype, suggesting that gain-of-function mutations of SCN8A can underlie EE."
25239001
SCN8A affects DNER
| 1
SCN8A binds DNER. 1 / 1
| 1
reach
"Furthermore, the MED complex contains both activating and inhibiting CDKs, the latter of which appear to constrain tumor suppressor and lineage identity gene associated super-enhancers, which raises interest in combining BET and MED complex negative regulatory CDK inhibitors for anti-cancer treatment [XREF_BIBR]."
29415456
SCN8A affects DB
| 1
SCN8A activates DB. 1 / 1
| 1
reach
"MED (75 micrograms) produced bilateral ocular hypotensive effects in both DB and NZW normal rabbits; however, HA (250 micrograms) lowered IOP unilaterally in NZW rabbits only."
7901309
SCN8A affects Clth
| 1
SCN8A activates Clth. 1 / 1
| 1
reach
"Complementation testing showed that the Asp981Val mutation in SCN8A underlies the Scn8a Clth phenotype."
19737145
SCN8A affects Cardiovascular Risk
| 1
SCN8A inhibits Cardiovascular Risk. 1 / 1
| 1
reach
"A brief description of the current MED diet based on the most significant studies and trials that demonstrated its properties has been provided by the AHA in the Guidelines on Lifestyle Management to Reduce Cardiovascular Risk and is summarized in XREF_TABLE [XREF_BIBR]."
27314382
SCN8A affects Cardiopulmonary Resuscitation
| 1
SCN8A activates Cardiopulmonary Resuscitation. 1 / 1
| 1
reach
"Medical emergency dispatcher (MED) telephone instructions to callers increase bystander CPR rates and survival after OHCA [XREF_BIBR]."
27067836
SCN8A affects CXCL2
| 1
SCN8A decreases the amount of CXCL2. 1 / 1
| 1
reach
"The MED feeding significantly downregulated the expressions of the p50, p65, TNFalpha, IL-6, IFNalpha, IFNbeta, IL-12-p40, and CXCL2 genes compared to the ED mice (XREF_FIG)."
22013387
SCN8A affects CTNNB1
| 1
SCN8A activates CTNNB1. 1 / 1
| 1
reach
"The fly MED12 and MED 13 homologs, kohtalo and skuld, respectively activate Wnt and beta-catenin target genes through direct interaction with the Wnt pathway component Pygopus."
24504440
SCN8A affects CRP
| 1
SCN8A binds CRP. 1 / 1
| 1
sparser
"CRP bound to Pn4 only in the cell wall region and C3 was located in this area whether or not CRP was present."
6747291
SCN8A affects CREBBP
| 1
SCN8A activates CREBBP. 1 / 1
| 1
reach
"The third of the trio of TFs identified here, MED, is also believed to direct the co-factor CBP to the genome XREF_BIBR and thus influence accessibility profiles."
23935523
SCN8A affects CREB
| 1
SCN8A phosphorylates CREB. 1 / 1
| 1
reach
"We previously reported that in human sun protected skin, 4 MED of UV resulted in the phosphorylation of MAPKAPK2, CREB, c-JUN, p38, GSK-3b and p53 leading to markedly increased levels of c-FOS, COX-2 and apoptosis in the epidermal cells."
26031292
SCN8A affects CPE
| 1
SCN8A inhibits CPE. 1 / 1
| 1
reach
"PCV and MED -4750 implants and PCV in PBS both prevented FHV-1-induced cytopathic effect (CPE; Figure XREF_FIG, second and fourth columns, respectively)."
24558980
SCN8A affects COL9A1
| 1
SCN8A activates COL9A1. 1 / 1
| 1
reach
"3 In contrast, autosomal dominant MED is genetically heterogeneous and although in the European population the largest proportion results from COMP mutations, other forms of MED can be caused by mutations in the genes encoding matrilin-3 (MATN3) and type IX collagen (COL9A1, COL9A2 and COL9A3)."
24595329
SCN8A affects COL10A1
| 1
SCN8A activates COL10A1. 1 / 1
| 1
reach
"However, the hypertrophic chondrocyte marker Col10a1 was greatly induced by TGF-beta1 treatment in both MED and SEMD MATN3 chondroprogenitors, while its levels remained low in WT MATN3 cells and the parental ATDC5 cells (XREF_FIG C (1-4))."
25196597
SCN8A affects CNM
| 1
SCN8A inhibits CNM. 1 / 1
| 1
reach
"MED and dexmedetomidine (DMED) also inhibited frequency related contractions of CNM induced by electrical stimulation of the cervical sympathetic trunk."
1680113
SCN8A affects CES1
| 1
SCN8A activates CES1. 1 / 1
| 1
reach
"Forty-four women (ages 27-68 years) who were diagnosed with overactive bladder (OAB) were divided into 2 treatment groups over 3 months : 24 women received rehabilitation (REH) and 20 women were treated with medication (MED) (oxybutynin ER)."
17549429
SCN8A affects CCN2
| 1
SCN8A inhibits CCN2. 1 / 1
| 1
reach
"Consumption of the MUFA and MED diets, compared with the SFA diet, decreased the expression of oxidative phosphorylation (OXPHOS) genes, plasma connective tissue growth factor, and apoB concentrations."
22623392
SCN8A affects CC14
| 1
SCN8A activates CC14. 1 / 1
| 1
reach
"The minimal effective dosage (MED) required to potentiate CC14 hepatotoxicity was about 1.0% BD or approximately 1 g BD/kg/day."
7135400
SCN8A affects CANT1
| 1
SCN8A activates CANT1. 1 / 1
| 1
reach
"MED resulting from recessively inherited mutations in the gene encoding calcium activated nucleotidase CANT1."
28742282
SCN8A affects CALM1
1 |
SCN8A binds CALM1. 1 / 1
1 |
signor
"Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1) in a Ca2+-dependent manner. This binding interaction significantly enhances slow inactivation-a channel-gating process linked to life-threatening idiopathic ventricular arrhythmias."
11807557
SCN8A affects CALM
| 1
CALM binds SCN8A. 1 / 1
| 1
reach
"MED sequesters phosphatidylinositol-4,5-bisphosphate, binds calmodulin with a K d of 4 nM, and penetrates the acyl chain zone of lipid bilayers with its five phenylalanines."
16365164
SCN8A affects CA1
| 1
SCN8A inhibits CA1. 1 / 1
| 1
reach
"At the cellular level, complete inactivation of mouse Scn8a reduces repetitive firing, resurgent current and persistent current in cerebellar Purkinje cells, prefrontal cortical pyramidal cells, and hippocampal CA1 cells."
28702509
SCN8A affects C10orf90
| 1
SCN8A increases the amount of C10orf90. 1 / 1
| 1
reach
"In addition to inhibiting inflammation and foam cell formation, we found that MED could significantly reduce the levels of blood fats, such as total triglyceride, total cholesterol, high-density lipoprotein, and low-density lipoprotein in mice (Additional file 3 : Figure S3)."
26045945
SCN8A affects B. tabaci complex
| 1
SCN8A activates B. tabaci complex. 1 / 1
| 1
reach
"What is more, the rapid invasion of MEAM1 and MED has caused the replacement of many indigenous cryptic species of the B. tabaci complex."
25077022
SCN8A affects B-APP
| 1
SCN8A activates B-APP. 1 / 1
| 1
reach
"This study compared results among subjects treated with brief Adlerian psychodynamic psychotherapy (B-APP), those treated with medication (MED), or those who experienced combined treatment (COM)."
17900875
SCN8A affects Ala-Pro
| 1
SCN8A inhibits Ala-Pro. 1 / 1
| 1
reach
"Among neuroleptics studied the minimal effective doses (MED) antagonizing AP hypothermia (APH) ranged from 0.006 (trifluperidol) to 0.5 mg/kg (chlorpromazine), while MED antagonizing PRB hypothermia (PRBH) ranged from 0.05 (trifluperidol and perphenazine) to 2.0 mg/kg (haloperidol)."
6104689
SCN8A affects Action potential
1 |
SCN8A activates Action potential. 1 / 1
1 |
signor
"The expression of voltage-gated sodium channels (NaVs) is a key feature for initiation and conduction of action potentials in excitable tissues and cells such as cardiac and skeletal muscle and neurons."
26043074
SCN8A affects APOB
| 1
SCN8A inhibits APOB. 1 / 1
| 1
reach
"Consumption of the MUFA and MED diets, compared with the SFA diet, decreased the expression of oxidative phosphorylation (OXPHOS) genes, plasma connective tissue growth factor, and apoB concentrations."
22623392
SCN8A affects APCS
| 1
SCN8A activates APCS. 1 / 1
| 1
reach
"MED infusion alone increased SAP maximally by 24.9%, MAP by 34.7% and a-vO2 diff by 222.5%, and reduced HR by 32.3%, but these changes were significantly attenuated by MK-467."
25201249
SCN8A affects AKT
| 1
SCN8A activates AKT. 1 / 1
| 1
reach
"We found that a single dose of 2-3 MED of SSL activated the PI3K and Akt signaling pathway with a small but statistically significant increase in cytoplasmic and nuclear staining of p-Akt at serine 473 (XREF_FIG, 1.4-fold increase at 5 hrs post SSL; p = 0.01)."
26031292
SCN8A affects ADIPOQ
| 1
SCN8A activates ADIPOQ. 1 / 1
| 1
reach
"Chronic ethanol ingestion led to more significant decreases in the hepatic expression of the adipoR1 and adipoR2 genes than in the ND mice, and MED feeding significantly restored these ethanol induced changes in the adiponectin receptor genes."
22013387
SCN8A affects ACOD1
| 1
SCN8A activates ACOD1. 1 / 1
| 1
reach
"Recent randomized clinical trials confirm equivalent long-term clinical outcomes for stable coronary artery disease (CAD) patients treated with intensive medical (MED) management with or without coronary revascularization (REV)."
22527794
SCN8A affects AA
| 1
SCN8A inhibits AA. 1 / 1
| 1
reach
"To investigate the cardiovascular and sedation reversal effects of IM administration of atipamezole (AA) in dogs treated with medetomidine hydrochloride (MED) or MED and vatinoxan (MK-467)."
31556714
SCN8A affects A2BR genes
| 1
SCN8A inhibits A2BR genes. 1 / 1
| 1
reach
"MED feeding significantly reversed the ethanol induced upregulation of the A1R and A2BR genes in the livers of the mice and restored the ethanol induced downregulation of the PPARalpha, CPT-1, MTP, LCAD, and MCAD genes in the livers of the mice."
22013387
SCN8A affects 4ME-glucobrassicin
| 1
SCN8A increases the amount of 4ME-glucobrassicin. 1 / 1
| 1
reach
"Although infestation by either biotype decreased the levels of total GS, aliphatic GS, glucoiberin, sinigrin, glucobrassicin, and 4OH-glucobrassicin, and the expression of related genes in cabbage, MED infestation increased the levels of 4ME-glucobrassicin, neoglucobrassicin, progoitrin, and glucoraphanin."
28861220
SCN8A affects 3',5'-cyclic AMP
| 1
SCN8A activates 3',5'-cyclic AMP. 1 / 1
| 1
reach
"Minimal effective dose (MED) to cause a significant (P less than.05) accumulation of cAMP was 0.1 microng/ml (2.2 x 10 (-8) M) for ACTH and 10 microng/ml (5.7 x10 (-3) M) for serotonin."
192084
SCN8A affects 24,25-Dihydroxyvitamin D
| 1
SCN8A activates 24,25-Dihydroxyvitamin D. 1 / 1
| 1
reach
"The dose of 1 MED applied on the whole body surface produces 10-20000 IU of vitamin D which equals 200-375 ml of cod liver oil [XREF_BIBR]."
27732653
SCN8A affects .005 mm/yr
| 1
SCN8A inhibits .005 mm/yr. 1 / 1
| 1
reach
"As shown in XREF_FIG, in the C2 segment, the most common site of atherosclerosis in the present study, LD, WT and INT increased approximately.08,.01 and.01 mm/yr, and MED decreased.005 mm/yr, respectively."
17596667
RbFox-1 proteins affects SCN8A
| 1
RbFox-1 proteins activates SCN8A. 1 / 1
| 1
reach
"Overexpression of RbFox-1 proteins promotes SCN8A exon 18A inclusion only in the absence of the ESS in a (T) GCATG dependent manner."
22434879
RNF2 affects SCN8A
| 1
RNF2 inhibits SCN8A. 1 / 1
| 1
reach
"RING1B depletion using an independent shRNA construct [XREF_BIBR] confirmed that SCN8A is repressed by RING1B in ES cells (XREF_SUPPLEMENTARY)."
27317769
Psi affects SCN8A
| 1
SCN8A binds Psi. 1 / 1
| 1
reach
"To determine the importance of the Psi MED interaction to development, we tested whether either transcriptional core or kinase MED subunits were capable of modifying the Psi ' wings up ' phenotype."
27207882
Pardoprunox affects SCN8A
| 1
Pardoprunox activates SCN8A. 1 / 1
| 1
reach
"Pardoprunox induced contralateral turning behaviour in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra pars compacta (SNpc) (MED = 0.03 mg/kg; po)."
20434890
PPY affects SCN8A
| 1
PPY activates SCN8A. 1 / 1
| 1
reach
"Topical application of control cream (pH 3.5), or creams containing glycolic acid (10%, pH 3.5) or salicylic acid (4%, pH 3.5) for 6 weeks (5 days and week) increased the MED (BIOL) to 137 mJ."
12460741
PORCN affects SCN8A
| 1
PORCN activates SCN8A. 1 / 1
| 1
reach
"These findings suggest that PPN stimulation induced PRs may be due to activation of muscarinic receptor sensitive channels, allowing MED neurons to respond to a transient, frequency dependent depolarization with long lasting stable states."
15890754
PKD affects SCN8A
| 1
SCN8A binds PKD. 1 / 1
| 1
reach
"SCN8A associated PKD like episodes."
28090678
NTA affects SCN8A
| 1
NTA inhibits SCN8A. 1 / 1
| 1
reach
"When given therapeutically (75 mumoles/kg between day 21 and 28) either NTA arrested the progression of the disease (MED, 25-75 mumoles/kg)."
2801322
NPNT affects SCN8A
| 1
NPNT activates SCN8A. 1 / 1
| 1
reach
"Data were prospectively collected from patients with MED treated with POEM at our institution."
31080116
NOG affects SCN8A
1 |
Transcriptionally active NOG increases the amount of SCN8A. 1 / 1
1 |
biopax:ctd
No evidence text available
27188386
NF2 affects SCN8A
| 1
NF2 activates SCN8A. 1 / 1
| 1
reach
"In squirrel monkeys, using a new hot-water bath tail-flick test, SCH 32615 significantly prolonged the escape latencies (MED = 100 mg/kg IV)."
2017447
NB-UVB affects SCN8A
| 1
NB-UVB activates SCN8A. 1 / 1
| 1
reach
"A short cycle of NB-UVB phototherapy can induce photoadaptation in vitiligo by increasing the MED and reducing skin erythema after stimulation with SSR."
31586997
NAV1 affects SCN8A
| 1
SCN8A binds NAV1. 1 / 1
| 1
sparser
"Mutations in human SCN8A , which encodes Nav1.6, are associated with cerebellar atrophy and ataxia ( xref )."
18930825
N-ethyl-N-nitrosourea affects SCN8A
| 1
N-ethyl-N-nitrosourea activates mutated SCN8A. 1 / 1
| 1
reach
"In prior studies, SWD were not detected in the ENU induced mutation Scn8a nmf58, with the amino acid substitution L1404H in the pore region of Scn8a domain 3."
19254928
MYC affects SCN8A
| 1
MYC activates SCN8A. 1 / 1
| 1
reach
"C-myc expression increased significantly 5 h after two times the minimal erythema dose (2 x MED) of UVR, while DNA synthesis of the irradiated skin had recovered from the UVR induced inhibition."
8274462
MXD1 affects SCN8A
| 1
SCN8A binds MXD1. 1 / 1
| 1
reach
"We reasoned that some components of the EGFR signaling pathway may be transcriptional upregulated by the activated MAD and MED complex, which in turn activate EGFR signaling."
30992503
MK-801 affects SCN8A
| 1
MK-801 inhibits SCN8A. 1 / 1
| 1
reach
"Compound 66 was highly potent for PDE10A (IC (50) = 1.4 nM), demonstrated high selectivity (> 200x) for the other PDEs, and was efficacious in animal models of psychoses; reversal of MK-801 induced hyperactivity (MED = 0.1 mg/kg) and conditioned avoidance responding (CAR; ID (50) = 0.2 mg/kg)."
22902656
MEAM1 affects SCN8A
| 1
SCN8A binds MEAM1. 1 / 1
| 1
reach
"We conducted laboratory experiments and field sampling to examine the effects of insecticide application on the competitive interactions between MEAM1 and MED."
23458717
MAPK14 affects SCN8A
1 |
SCN8A binds MAPK14. 1 / 1
1 |
hprd
No evidence text available
16014723
MANF affects SCN8A
| 1
MANF activates mutated SCN8A. 1 / 1
| 1
reach
"We therefore investigated whether the relative levels of Armet and Creld2 would also be increased in CHO and HEK-293 cell culture models expressing the p.V194D MED mutation."
23956175
L-dopa affects SCN8A
| 1
L-dopa activates SCN8A. 1 / 1
| 1
reach
"In the PD MED study, patients treated with levodopa had a higher quality of life and only a slightly increased rate of dyskinesia (36% in the levodopa group versus 33% in the levodopa sparing group) and no difference in motor fluctuation after 7 years of follow-up, which included 1620 patients with early PD [XREF_BIBR]."
26989558
L-ascorbic acid affects SCN8A
| 1
L-ascorbic acid binds SCN8A. 1 / 1
| 1
reach
"The inverse association between vitamin C and MED was against our hypothesis."
14506481
KIDINS220 affects SCN8A
| 1
KIDINS220 activates SCN8A. 1 / 1
| 1
reach
"Exposure of an adult in a bathing suit to an amount of sunlight that causes a slight pinkness to the skin (1 MED, known as a minimal erythemal dose) is equivalent to ingesting approximately 20,000 IU of vitamin D. XREF_BIBR Thus exposure of arms (18% body surface) to sunlight between 11 a.m. and 2 p.m. for an amount of time to cause an MED would be equivalent to ingesting about 3600 IU vitamin D."
24494046
KHDRBS3 affects SCN8A
| 1
SCN8A binds KHDRBS3. 1 / 1
| 1
sparser
"Such effects may well be related to function in the pyramidal neuron AIS, as Na V 1.6 expression is significantly higher in epileptic mice deficient for CELF4, an RNA binding protein that binds to Scn8a mRNA [ xref ]."
24657915
IL10 affects SCN8A
1 |
Transcriptionally active IL10 decreases the amount of SCN8A. 1 / 1
1 |
signor
"Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α."
23357618
ID1 affects SCN8A
| 1
Mutated SCN8A binds ID1. 1 / 1
| 1
reach
"XREF_BIBR, reported a cohort of Chinese patients and identified five de novo SCN8A variants that stated to be the first reported in Chinese patients with epilepsy and ID/DD, in our cohort we identified a novel de novo SCN8A mutation associated with unclassified EEEs and moderate ID, thus enriching the relation between SCN8A variants and EIEE."
28387369
Histone_H4 affects SCN8A
| 1
Acetylated Histone_H4 increases the amount of SCN8A. 1 / 1
| 1
reach
"Furthermore, immunoprecipitation and chromatin immunoprecipitation assays demonstrated that L5-VRT increased the binding of STAT3 to the Scn8a (encoding Nav1.6) promoter and the interaction between STAT3 and p300, which contributed to the enhanced transcription of Scn8a by increasing histone H4 acetylation in Scn8a promoter in DRG."
30736806
HTT affects SCN8A
| 1
HTT inhibits SCN8A. 1 / 1
| 1
reach
"The percentage of utilizers exceeding HD limits of 360mg, 240mg, and 120mg MED decreased by 87.3%, 79.8%, and 75.2% from baseline, respectively."
30690166
HTR2A affects SCN8A
| 1
HTR2A inhibits SCN8A. 1 / 1
| 1
reach
"The selective 5-HT2 antagonist LY53857 (0.3-3.0 mg/kg) administered alone had no effect on locomotor activity but reversed (MED = 0.1 mg/kg) the effects of PCP."
9122367
HPD affects SCN8A
| 1
HPD inhibits SCN8A. 1 / 1
| 1
reach
"The PPD antihistamines, namely terfenadine and astemizole, inhibited cough (MED 30 and 10 mg/kg p.o.) without sedative effects."
9691225
GTF2H4 affects SCN8A
| 1
GTF2H4 activates SCN8A. 1 / 1
| 1
reach
"MED will also bring TFIIH kinase activity into close proximity with the CTD of RNA Pol II, consistent with MED stimulating TFIIH dependent CTD phosphorylation and RNA Pol II promoter clearance."
27207882
GNAO1 affects SCN8A
1 |
SCN8A binds GNAO1. 1 / 1
1 |
hprd
No evidence text available
10066808
GAL affects SCN8A
| 1
GAL inhibits SCN8A. 1 / 1
| 1
reach
"Central administration of galanin in the mouse dose-dependently blocked the hypothermia induced by the muscarinic receptor agonist, 2-ethyl 8-methyl-2,8-diazospiro [4,5] decan-1,3-dion hydrobromide, RS86 (minimum effective dose, MED = 3 nmol) and the acetylcholinesterase inhibitor tetrahydroaminoacridine, (MED = 3 nmol)."
7517882
GAC codon p. affects SCN8A
| 1
GAC codon p. activates SCN8A. 1 / 1
| 1
reach
"In contrast, the duplication of a single GAC codon p. (Asp473dup) consistently causes MED (n = 4/300), whereas the duplication of two GAC codons p. (Asp472_Asp473dup) causes PSACH (n = 2/300)."
24595329
FUBP1 affects SCN8A
| 1
SCN8A binds FUBP1. 1 / 1
| 1
reach
"Further studies are required to determine whether human FUBP1 also interacts with MED to modulate expression of the mammalian MYC oncogene."
28398229
EZH2 affects SCN8A
| 1
EZH2 activates SCN8A. 1 / 1
| 1
reach
"Knockdown of REST or EZH2 with specific siRNAs in SY5Y cells also lead to significant up-regulation of SCN8A, further supporting the role of REST and EZH2 in participating in SCN8A gene regulation."
28842554
ETV3 affects SCN8A
| 1
ETV3 inhibits SCN8A. 1 / 1
| 1
reach
"After 12 weeks on the trial, the number of MetS variables reduced to 2.95 +/- 0.26 in the PED arm (P = 0.01), and to 3.56 +/- 0.28 in the MED arm (P = 0.07)."
18983673
ESR1 affects SCN8A
1 |
Transcriptionally active ESR1 increases the amount of SCN8A. 1 / 1
1 |
signor
"In this study, quantitative real-time PCR analysis showed that the gene expression levels of TTX-S (Nav1.1 and Nav1.7) and TTX-R (Nav1.8 and Nav1.9) sodium channel subtypes were elevated in DRGs of αERKO and βERKO mice, whereas Nav1.6 mRNA decreased in αERKOs but showed no changes in βERKO mice"
22169964
EMP1 affects SCN8A
| 1
EMP1 activates SCN8A. 1 / 1
| 1
reach
"While TMP increased MED when taken 2 h before UV exposure (p less than 0.001), 8 MOP had the opposite effect (p less than 0.01)."
6162327
EGF affects SCN8A
| 1
EGF activates SCN8A. 1 / 1
| 1
reach
"Cavernous cGMP concentrations were markedly increased in MED rats treated with EGF but were still lower than those in the controls."
29044143
DNER affects SCN8A
| 1
SCN8A binds DNER. 1 / 1
| 1
reach
"Furthermore, the MED complex contains both activating and inhibiting CDKs, the latter of which appear to constrain tumor suppressor and lineage identity gene associated super-enhancers, which raises interest in combining BET and MED complex negative regulatory CDK inhibitors for anti-cancer treatment [XREF_BIBR]."
29415456
CXCL8 affects SCN8A
| 1
CXCL8 activates SCN8A. 1 / 1
| 1
reach
"However, a double- blind, randomized trial of 28 patients supplemented with 4 g/day of 95% of ethyl esters of EPA or oleic acid for three months found no evidence that the MED response evoked by omega-3 FA was mediated by the pro inflammatory cytokines IL-8, TNF-alpha, IL-6 or IL-1beta."
26861407
CRP affects SCN8A
| 1
SCN8A binds CRP. 1 / 1
| 1
sparser
"CRP bound to Pn4 only in the cell wall region and C3 was located in this area whether or not CRP was present."
6747291
CRELD2 affects SCN8A
| 1
CRELD2 activates mutated SCN8A. 1 / 1
| 1
reach
"We therefore investigated whether the relative levels of Armet and Creld2 would also be increased in CHO and HEK-293 cell culture models expressing the p.V194D MED mutation."
23956175
COL2A1 affects SCN8A
| 1
Mutated COL2A1 activates SCN8A. 1 / 1
| 1
reach
"In conclusion, the above evidence suggests that the family presented in this report suffers from a medium severity MED caused by COL2A1 mutation, with predominant premature osteoarthritis affecting mostly hips and less the spine."
30740902
Blood Pressure affects SCN8A
| 1
Blood Pressure glycosylates SCN8A. 1 / 1
| 1
reach
"BP : Blood pressure; CSIRO : CSIRO diet; DBP : Diastolic blood pressure; HbA1c : Glycosylated haemoglobin; HDL : High-density lipoprotein; hs-CRP : high sensitivity c-reactive protein; LDL : low-density lipoprotein; MED : Mediterranean diet; PA : physical activity; SB : South Beach diet; SBP : Systolic blood pressure."
24886191
BET bromodomain affects BRD4, and SCN8A
| 1
SCN8A binds BRD4 and BET bromodomain. 1 / 1
| 1
reach
"Supporting a functional interaction of BRD4 and MED at super-enhancers, BET bromodomain inhibition releases the mediator complex from select cis-regulatory elements, at least in leukemia cells [XREF_BIBR]."
29415456
BCAM affects SCN8A
| 1
BCAM inhibits SCN8A. 1 / 1
| 1
reach
"Furthermore, Lu 28-179 reversed shock induced suppression of drinking in the rat (MED = 18,000 nmol/kg = 10 mg/kg)."
9400007
ATF2 affects SCN8A
| 1
ATF2 inhibits SCN8A. 1 / 1
| 1
sparser
"Lentiviral Cre -induced inactivation of the Scn8a gene in the hippocampus reduces seizure generation in vivo ."
24704313
ARSD affects SCN1A, SCN2A, SCN3A, SCN7A, and SCN8A
| 1
SCN1A binds SCN2A, SCN3A, SCN7A, SCN8A, and ARSD. 1 / 1
| 1
sparser
"SCN1A , SCN2A , SCN3A , SCN7A and SCN8A are associated with ASD [ xref ]."
25592685
ACP5 affects SCN8A
| 1
ACP5 inhibits SCN8A. 1 / 1
| 1
reach
"The potential of trap and barrier cropping to decrease densities of the whitefly Bemisia tabaci MED on cotton in China."
31219649
5-HT2A/2C affects SCN8A
| 1
5-HT2A/2C inhibits SCN8A. 1 / 1
| 1
reach
"Similarly, the selective 5-HT2A/2C antagonist ritanserin (0.001-1.0 mg/kg) alone had no effect on locomotor activity, but reversed (MED = 0.01 mg/kg) the effects of PCP."
9122367
1-phenylpropan-2-amine affects SCN8A
| 1
1-phenylpropan-2-amine activates SCN8A. 1 / 1
| 1
reach
"It can be seen in Fig. 4 that amphetamine dose-dependently increased ipsiversively circling in MED rats and contraver- sive circling in LAT rats while CTL rats showed little effect."
4080836
(1E,4E,8E)-alpha-humulene affects SCN8A
| 1
(1E,4E,8E)-alpha-humulene activates SCN8A. 1 / 1
| 1
reach
"The repellent activity measured by minimum effective dosage (MED) for alpha-bisabolol and alpha-humulene produced MED values of 0.094 and 0.104 mg/cm2, respectively, as compared with 0.023 mg/cm2 of DEET."
28399215