INDRA statements for SCN1A

This page allows you to curate the loaded statements. For more information please see the manual.

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
SCN1A affects DHPS
| 5 22
SCN1A activates DHPS.
| 16
Mutated SCN1A activates DHPS. 9 / 9
| 9
reach
"Dravet syndrome is most frequently caused by various mutations of the SCN1A gene encoding the type 1 subunit of the neuronal voltage gated sodium channel."
27021235
reach
"Ser487GlufsTer6) adds to the spectrum of SCN1A mutations causing DS."
27021235
reach
"DS is most frequently caused by various mutations of the SCN1A gene encoding the subunit 1 of the neuronal voltage gated sodium channel [XREF_BIBR]."
27021235
reach
"SCN1A Mutations cause DS."
22341965
reach
"Dravet syndrome (DS), a devastating epileptic encephalopathy, is mostly caused by mutations of the SCN1A gene, coding for the voltage gated Na (+) channel Na (V) 1.1 alpha subunit."
22150645
reach
"XREF_BIBR reported in 2001 that SCN1A mutations caused DS, it has been found that 70-80% of DS cases are caused by mutations in SCN1A."
28079314
reach
"In a cohort of 10 adult patients with DS caused by SCN1A mutations, we investigated seizure frequency, history of cSE, and gait."
22780858
reach
"Previous studies have shown that truncated mutations of SCN1A cause DS, the severest phenotype in genetic epilepsy due to sodium channel defects."
26311622
reach
"Dravet syndrome (DS) is caused by dominant mutations of the SCN1A gene, encoding the NaV 1.1 sodium channel alpha subunit."
23663038
SCN1A activates DHPS. 7 / 7
| 7
reach
"In 85% of cases, DS is caused by mutations in the SCN1A gene, resulting in loss of function of the type I voltage gated sodium channel (Na v 1.1)."
23318929
reach
"In approximately 60-80% of patients, DS is caused by a mutation in SCN1A, the gene encoding the alpha-subunit of the voltage gated sodium channel NaV1.1 whose function contributes to the rising phase of the action potential (Bender etal."
27069631
reach
"Broadly, SCN1A haploinsufficiency tends to cause DS as does SCN1B loss-of-function, however somewhat more tenuously."
27143702
reach
"Haploinsufficiency of the SCN1A gene encoding voltage gated sodium channel Na V 1.1 causes Dravet Syndrome (DS), a childhood neuropsychiatric disorder including recurrent intractable seizures, cognitive deficit, and autism-spectrum behaviors."
22914087
reach
"Rare mutations in SCN1A cause a wide spectrum of epilepsy syndromes, including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (DS, also known as severe myoclonic epilepsy of infancy) 5, depending on the nature of the mutation and possible genetic modifiers on other genes 30."
25344690
reach
"In more than 70% of cases, DS is caused by de novo mutations in the SCN1A gene which encodes the alpha subunit of the neuronal voltage gated sodium channel Na v 1.1 XREF_BIBR, XREF_BIBR."
23821540
reach
"Mouse models of DS have been generated by targeted deletion of mouse Scn1a and knock-in of a human SCN1A premature truncation mutation causing DS XREF_BIBR, XREF_BIBR."
23821540
SCN1A inhibits DHPS.
| 6
SCN1A inhibits DHPS. 4 / 4
| 4
reach
"Our data present a case of Dravet syndrome caused by a novel heterozygous SCN1A deletion (c. 1458_1465delCTCTAAGT) in two affected siblings."
27021235
reach
"Moreover, our results show that mutation of one allele of Scn1a also dramatically impairs sleep homeostasis in DS mice, as assessed from the large reduction in the rebound of slow wave activity after sleep deprivation."
25766678
reach
"DS is caused by heterozygous loss-of-function mutations in the SCN1A gene 7, which encodes the pore forming alpha-subunit of the brain voltage gated sodium channel type-1 (Na V 1.1) 8."
22914087
reach
"DS is caused by heterozygous loss-of- function mutations in the SCN1A gene, which encodes the pore forming alpha subunit of the voltage gated sodium channel Nav1.1."
28244991
Mutated SCN1A inhibits DHPS. 2 / 2
| 2
reach
"DS, the more severe disorder, is often caused by loss-of-function SCN1A mutations, while GEFS+ results from subtle changes in the biophysical properties of Na v 1.1 channels."
21801172
reach
"Loss-of-function SCN1A mutations cause DS, a debilitating form of epilepsy characterized by complex febrile seizures in the first year of life, partial and/or generalized afebrile epilepsy, intellectual disability, and ataxia."
22926190
SCN1A binds DHPS.
| 5
SCN1A binds DHPS. 5 / 5
| 5
sparser
"The primary defect in DS associated with SCN1A mutations is loss of Na V 1.1 function owing to truncating mutations, non-truncating alleles that confer impaired trafficking, or other potential mechanisms."
24434335
sparser
"The increase in lifespan and seizure thresholds is consistent with our previous results examining the interactions between theScn8a medjo and GEFS+ or DS Scn1a mutants ( xref ; xref )."
26410685
sparser
"Previous studies of several SCN1A mutants associated with GEFS+ and DS ( xref , xref , xref ) showed increased persistent current which may be a contributing factor to the complex epileptic phenotypes."
21864321
sparser
"To summarize, there is a strong association of SCN1A mutations with DS, and the evidence suggests a relationship between the location and type of SCN1A mutation and the severity of the epilepsy phenotype."
22341965
sparser
"Phenotypically, early infantile SCN1A encephalopathy is associated with more profound developmental impairments than DS; all patients included in the study were nonambulatory, and the majority required feeding tubes."
31257984
SCN1A affects pyraclofos
| 14
SCN1A activates pyraclofos.
| 13
SCN1A activates pyraclofos. 11 / 11
| 11
reach
"Dravet Syndrome (DS) is a neurodevelopmental genetic disorder caused by mutations in the SCN1A gene encoding the subunit of the NaV1.1 voltage gated sodium channel that controls neuronal action potential firing."
31830809
reach
"Dravet Syndrome is a severe childhood epileptic disorder caused by haploinsufficiency of the SCN1A gene encoding brain voltage gated sodium channel Na V 1.1."
31346088
reach
"In the majority (80%) of cases, Dravet Syndrome is caused by mutations in the SCN1A gene, encoding the voltage gated sodium channel Na V 1.1, which is abundant in the central nervous system."
31533007
reach
"We studied a mouse model of Dravet syndrome, a severe childhood epilepsy caused by mutations in the human SCN1A gene encoding the voltage gated sodium channel subunit Na v 1.1."
25042160
reach
"BackgroundDravet syndrome, a severe childhood epilepsy characterized by persistent, often drug resistant seizures and progressive developmental delay is known to be caused by mutations in the SCN1A gene encoding the voltage gated sodium channel subunit alpha NA V 1.1."
27154366
reach
"XREF_BIBR In at least 70% of children, Dravet syndrome is caused by a heterozygous mutation in the SCN1A gene, XREF_BIBR, XREF_BIBR encoding the alpha-subunit of the neuronal voltage gated sodium channel."
23762420
reach
"Severe Myoclonic Epilepsy in Infancy (SMEI) is an intractable epileptic syndrome with onset in the first year of life and is commonly caused by de novo mutations in the SCN1A gene, encoding the alpha1-subunit of the neuronal voltage gated sodium channel."
16430863
reach
"It is mainly caused by mutations in SCN1A gene, encoding type 1 voltage gated sodium channel alpha-subunit (NaV1.1), and GABRA1 gene, encoding the alpha1 subunit of the gamma-aminobutyric acid type A (GABA A) receptor, while seldom related with SCN9A gene, encoding the voltage gated sodium channel NaV1.7."
32062735
reach
"Dravet syndrome is a rare developmental epilepsy syndrome caused by autosomal dominant mutations in the SCN1A gene encoding the voltage gated sodium channel NaV1.1, and is characterized by intractable epilepsy, ID, and autism."
25181011
reach
"Dravet syndrome is a severe epileptic encephalopathy mainly caused by heterozygous mutations in the SCN1A gene encoding a voltage gated sodium channel Nav1.1."
23922229
reach
"Dravet syndrome (DS) is a neurodevelopmental genetic disorder caused by mutations in the SCN1A gene encoding the alpha subunit of the NaV1.1 voltage gated sodium channel that controls neuronal action potential firing."
31830809
Mutated SCN1A activates pyraclofos. 2 / 2
| 2
reach
"DS is an autosomal dominant disease that is mainly caused by various mutations of the SCN1A gene encoding the type 1 subunit of the neuronal voltage gated sodium channel [XREF_BIBR]."
27021235
reach
"Dravet syndrome is most frequently caused by various mutations of the SCN1A gene encoding the type 1 subunit of the neuronal voltage gated sodium channel."
27021235
SCN1A decreases the amount of pyraclofos.
| 1
Mutated SCN1A decreases the amount of pyraclofos. 1 / 1
| 1
reach
"Dravet syndrome is a severe infant-onset epileptic encephalopathy most often caused by de novo mutation of SCN1A resulting in heterozygous loss-of-function of the Nav1.1 voltage gated sodium channel 1."
29127345
SCN1A affects sodium(1+)
1 | 12
SCN1A inhibits sodium(1+).
| 6
Mutated SCN1A inhibits sodium(1+). 4 / 4
| 4
reach
"In addition, the model experiment of gene knockout mice for simulating human channel diseases has verified that SCN1A mutation causes reduced expression level of sodium channel subtype Nav1.1, leading to decreased excitatory of inhibitory neurons, functional decline in inhibitory loop and increased neuronal excitability, which are necessary for the onset of epileptic seizures [XREF_BIBR]."
28474565
reach
"Differential effects on sodium current impairments by distinct SCN1A mutations in GABAergic neurons derived from Dravet syndrome patients."
29295803
reach
"These results suggest that this SCN1A mutation predominantly impairs sodium channel activity in interneurons, leading to decreased inhibition."
20100831
reach
"SCN1A mutations have been proposed to preferentially impair the sodium channel activity of GABAergic interneurons, diminishing their activity [XREF_BIBR]."
21826277
SCN1A inhibits sodium(1+). 2 / 2
| 2
reach
"Lower levels of SCN1A, SCN2A, SCN3A, SCN4A and SCN8A expression have also been reported in heart and shown to contribute approximately 23% of the total functional sodium channels in mouse ventricular myocytes and 27% in human atrial myocytes, based on TTX sensitivity."
27702655
reach
"It is caused by loss-of-function mutations in the gene SCN1A encoding brain sodium channel Nav1.1, which specifically impair action potential firing by GABAergic inhibitory interneurons and disinhibit neural circuits in the brain."
27481715
SCN1A activates sodium(1+).
| 6
SCN1A activates sodium(1+). 5 / 5
| 5
reach
"Dravet syndrome (DS) is a childhood epilepsy syndrome caused by heterozygous mutations in the SCN1A gene encoding voltage gated sodium channel Na v 1.1."
31400703
reach
"The mismatch was first noted when hemizygous reduction of the Scn1a subunit was found to dramatically reduce sodium current in mouse interneurons, while sparing pyramidal neurons, despite apparently equivalent levels of gene expression."
28428202
reach
"Three recognized sodium channel gene EEs are caused by mutations in SCN8A, SCN1A (Dravet syndrome), SCN2A, and SCN8A."
27270488
reach
"Scn1a can enhance persistent inward sodium currents, and recent studies indicate that a mutation in this gene might play a role in migraine development and in epilepsy [XREF_BIBR, XREF_BIBR]."
24260241
reach
"SCN1A loss-of-function impairs sodium currents and spiking in hippocampal GABAergic interneurons, without a detectable effect on excitatory pyramidal neurons."
26985722
Mutated SCN1A activates sodium(1+). 1 / 1
| 1
reach
"The two novel SCN1A mutations located in the voltage sensing S4 segment of domain II, R859H and R865G, both produced functional sodium channels and were further examined."
21864321
SCN1A increases the amount of sodium(1+).
1 |
SCN1A increases the amount of sodium(1+). 1 / 1
1 |
signor
"Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential."
27262167
DHPS affects SCN1A
| 5 4
DHPS binds SCN1A.
| 5
SCN1A binds DHPS. 5 / 5
| 5
sparser
"The primary defect in DS associated with SCN1A mutations is loss of Na V 1.1 function owing to truncating mutations, non-truncating alleles that confer impaired trafficking, or other potential mechanisms."
24434335
sparser
"The increase in lifespan and seizure thresholds is consistent with our previous results examining the interactions between theScn8a medjo and GEFS+ or DS Scn1a mutants ( xref ; xref )."
26410685
sparser
"Previous studies of several SCN1A mutants associated with GEFS+ and DS ( xref , xref , xref ) showed increased persistent current which may be a contributing factor to the complex epileptic phenotypes."
21864321
sparser
"To summarize, there is a strong association of SCN1A mutations with DS, and the evidence suggests a relationship between the location and type of SCN1A mutation and the severity of the epilepsy phenotype."
22341965
sparser
"Phenotypically, early infantile SCN1A encephalopathy is associated with more profound developmental impairments than DS; all patients included in the study were nonambulatory, and the majority required feeding tubes."
31257984
DHPS activates SCN1A.
| 3
DHPS activates mutated SCN1A. 2 / 2
| 2
reach
"Previous studies have shown that truncated mutations of SCN1A cause DS, the severest phenotype in genetic epilepsy due to sodium channel defects."
26311622
reach
"6 It has been suggested that DS causing SCN1A mutations reduce the activity of cortical inhibitory networks, with the resultant imbalance of neuronal activity leading to seizures."
28356460
DHPS activates SCN1A. 1 / 1
| 1
reach
"Together these findings suggest that the circadian and sleep physiology defects in DS mice may be caused by distinct functional impairments arising from the deletion of Na V 1.1 channels in different neuronal populations.In a recent study, Papale et al. (2013) characterized sleep abnormality in a mouse model of GEFS + expressing the R1649H mutation in one allele of Scn1a."
25766678
DHPS inhibits SCN1A.
| 1
DHPS inhibits SCN1A. 1 / 1
| 1
reach
"Here we will review the preclinical animal models for DS featuring inactivation of SCN1A (including zebrafish and mice) with an emphasis on seizure phenotypes and behavioral comorbidities."
29915537
SCN1A affects sodium atom
| 8
SCN1A activates sodium atom.
| 5
SCN1A activates sodium atom. 5 / 5
| 5
reach
"Dravet syndrome (DS) is an infantile epileptic encephalopathy mainly caused by de novo mutations in the SCN1A gene encoding the alpha1 subunit of the voltage gated sodium channel Na v 1.1."
29453127
reach
"Dravet syndrome (DS) is a childhood epilepsy syndrome caused by heterozygous mutations in the SCN1A gene encoding voltage gated sodium channel Na v 1.1."
31400703
reach
"SCN1A haploinsufficiency producing Na V 1.1 dysfunction mainly affects GABAergic neurons."
27817982
reach
"Scn1a null mice have increased Na v 1.3 expression in the hippocampus [XREF_BIBR]."
24155976
reach
"Dravet syndrome is a devastating infantile-onset epilepsy syndrome with cognitive deficits and autistic traits caused by genetic alterations in SCN1A gene encoding the alpha-subunit of the voltage gated sodium channel Na v 1.1."
23639079
SCN1A inhibits sodium atom.
| 3
Mutated SCN1A inhibits sodium atom. 2 / 2
| 2
reach
"SCN1A provide instructions for making alpha subunit of a sodium channel called Nav1.1, and a recent study suggested that milder phenotypes of SCN1A mutation can cause lesser impairment of Na + channel function leading to reduced Na + currents in GABAergic inhibitory interneuron or electrical network hyperexcitability in patients with these mutations."
28775949
reach
"Animal studies have revealed that SCN1A mutations causing loss of function of Na v 1.1 impair the firing of GABAergic neurons compared to pyramidal cells."
22341965
SCN1A inhibits sodium atom. 1 / 1
| 1
reach
"Scn1a +/- mice have reduced Na + currents and impaired action potential firing in hippocampal interneurons and cerebellar Purkinje neurons XREF_BIBR, XREF_BIBR, which are GABAergic neurons."
22914087
SCN1A affects GADD45GIP1
| 8
SCN1A decreases the amount of GADD45GIP1.
| 4
SCN1A decreases the amount of GADD45GIP1. 4 / 4
| 4
reach
"In the current report and our previous study, we have demonstrated that NAC-1 proteins negatively regulate the expression of Gadd45gip1 (Crif1) and Gadd45gamma."
19305429
reach
"In summary, NAC-1 contributes to tumor growth and survival by at least inhibiting Gadd45GIP1 expression, which has a tumor suppressor effect in cancer cells."
17804717
reach
"NAC-1 knockdown in both SKOV3 and HeLa cells that expressed abundant endogenous NAC-1 induced Gadd45GIP1 expression transcriptionally; on the other hand, engineered expression of NAC-1 in NAC-1-negative RK3E and HEK293 cells suppressed endogenous Gadd45GIP1 expression."
17804717
reach
"For example, NAC-1, a BTB/POZ protein, repressed transcription of the CKbetaBP2 and CRIF1 gene."
24103312
SCN1A inhibits GADD45GIP1.
| 3
SCN1A inhibits GADD45GIP1. 3 / 3
| 3
reach
"In addition to the established NF-kappaB-Gadd45 molecular circuit, downregulation of Gadd45gip1 by NAC-1 overexpression represents another molecular switch to suppress Gadd45 death signals."
19305429
reach
"Ectopic expression of NAC-1 or knockdown of Gadd45gip1 conferred paclitaxel resistance, whereas NAC-1 knockdown or ectopic expression of Gadd45gip1 increased paclitaxel sensitivity."
19305429
reach
"Ectopic expression of NAC-1 or knockdown of Gadd45gip1 conferred paclitaxel resistance, while NAC-1 knockdown or ectopic expression of Gadd45gip1 increased paclitaxel sensitivity."
19305429
SCN1A increases the amount of GADD45GIP1.
| 1
Modified SCN1A increases the amount of GADD45GIP1. 1 / 1
| 1
reach
"NAC-1 knockdown in both SKOV3 and HeLa cells that expressed abundant endogenous NAC-1 induced Gadd45GIP1 expression transcriptionally; on the other hand, engineered expression of NAC-1 in NAC-1-negative RK3E and HEK293 cells suppressed endogenous Gadd45GIP1 expression."
17804717
AAV-NaVbeta1 affects SCN1A
| 8
AAV-NaVbeta1 activates SCN1A.
| 7
AAV-NaVbeta1 activates SCN1A. 7 / 7
| 7
reach
"However, in the AAV-NaVbeta1 treatment groups, Scn1a +/- mice treated with AAV-NaVbeta1 traveled farther than WT mice treated with either AAV-EV or AAV-NaVbeta1 (XREF_FIG; genotype main effect, F 1,62 = 9.32, p < 0.01)."
31830809
reach
"Male Scn1a +/- mice treated with AAV-NaVbeta1 showed reduced spontaneous seizures and normalization of motor activity and performance on the elevated plus maze test."
31830809
reach
"24 In the passive avoidance test, female Scn1a +/- mice treated with AAV-EV or with AAV-NaVbeta1 both displayed reduced latency to crossover compared with WT mice injected with AAV-EV (XREF_FIG; treatment main effect, F 1,46 = 1.90, p < 0.01)."
31830809
reach
"Using the anti-NaVbeta1 antibody, the level of total NaVbeta1 protein in Scn1a +/- mice treated with AAV-NaVbeta1 was 8.3 times higher compared with WT mice treated with AAV-EV (XREF_FIG), whereas using an anti-c-myc antibody to assess transgene generated NaVbeta1 revealed similar levels in WT and Scn1a +/- mice treated with AAV-NaVbeta1 (XREF_FIG)."
31830809
reach
"Survival of Scn1a +/- mice treated with AAV-NaVbeta1."
31830809
reach
"In contrast, WT and Scn1a +/- treated with AAV-NaVbeta1 did not differ in the time spent in the open arms, indicating correction of this endophenotype after treatment with AAV-NaVbeta1 (XREF_FIG; treatment main effect, F 1,62 = 3.66, p < 0.01; genotype main effect, F 1,62 = 8.08, p < 0.01)."
31830809
reach
"In contrast, there was no statistical difference in the frequency of tonic seizures in the female Scn1a +/- mice treated with AAV-NaVbeta1 compared with female Scn1a +/- mice with AAV-EV (XREF_FIG; t = 0.75, p> 0.05)."
31830809
AAV-NaVbeta1 inhibits SCN1A.
| 1
AAV-NaVbeta1 inhibits SCN1A. 1 / 1
| 1
reach
"These observations indicate that AAV-NaVbeta1 did not reduce the susceptibility of Scn1a +/- mice to heat induced seizures."
31830809
SCN1A affects NAV1
| 2 5
SCN1A inhibits NAV1.
| 3
SCN1A inhibits NAV1. 2 / 2
| 2
reach
"It is caused by loss-of-function mutations in the gene SCN1A encoding brain sodium channel Nav1.1, which specifically impair action potential firing by GABAergic inhibitory interneurons and disinhibit neural circuits in the brain."
27481715
reach
"XREF_BIBR, XREF_BIBR Notably, conditional Scn1a +/- mice that have reduced Nav1.1 protein only in GABAergic interneurons show an overall phenotype similar to global Scn1a +/- mice."
31830809
Mutated SCN1A inhibits NAV1. 1 / 1
| 1
reach
"In addition, the model experiment of gene knockout mice for simulating human channel diseases has verified that SCN1A mutation causes reduced expression level of sodium channel subtype Nav1.1, leading to decreased excitatory of inhibitory neurons, functional decline in inhibitory loop and increased neuronal excitability, which are necessary for the onset of epileptic seizures [XREF_BIBR]."
28474565
SCN1A binds NAV1.
| 2
SCN1A binds NAV1. 2 / 2
| 2
sparser
"A recent report of 9 patients with an early profound form of SMEI xref reported one patient with an Nav1.1-p."
29466837
sparser
"Mutations of the gene SCN1A (which encodes Nav1.1) in the nervous system have been associated with human inherited epileptic syndromes and familial hemiplegic migraine, suggesting that Nav1.1 might participate in the genesis of migraine ( xref ; xref )."
21714116
SCN1A activates NAV1.
| 2
SCN1A activates NAV1. 2 / 2
| 2
reach
"SCN1A haploinsufficiency producing Nav1.1 dysfunction mainly affects GABAergic neurons, which according to the affected site, cortex, cerebellum, basal ganglia, or hypothalamus, are the cause of epileptic seizure, ataxia, crouching gait, thermal dysregulation, and sleep disturbances [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
29764460
reach
"Furthermore, Dravet syndrome, one of the most severe forms of childhood epilepsy, is caused by mutations in SCN1A encoding Nav1.1 [reviewed in], or a mutation in SCN1B encoding Nav channel beta1 subunit."
23834220
SCN1A affects SMEI
| 6
SCN1A activates SMEI.
| 4
SCN1A activates SMEI. 3 / 3
| 3
reach
"A redefinition of Dravet syndrome, in view of the genetic origin, may then be possible.In our first publication [4], we speculated that SMEI was only caused by truncating mutations in SCN1A."
15087100
reach
"We speculate that this mutation likely promotes seizure susceptibility and worsens the SMEI phenotype caused primarily by the SCN1A mutation.SCN1A is expressed in GABAergic interneurons, haploinsufficiency of Na v 1.1 channels in inhibitory neurons is the cause of seizures in a model mouse harboring a nonfunctional SCN1A mutation (Yu et al., 2006)."
18755274
reach
"SMEI is caused by mutations in SCN1A encoding Na v 1.1."
22701429
Mutated SCN1A activates SMEI. 1 / 1
| 1
reach
"Unilateral motor seizures may be a specific clinical characteristic of SMEI caused by SCN1A mutations."
12821740
SCN1A inhibits SMEI.
| 2
SCN1A inhibits SMEI. 2 / 2
| 2
reach
"Heterozygous Deletion of Scn1a Is Sufficient to Produce Phenotypic Features of SMEI."
21463282
reach
"These results provide evidence that heterozygous deletion of Scn1a is sufficient to produce the key epileptic phenotypic features of SMEI."
21463282
SCN1A affects Gadd45gamma
| 6
SCN1A decreases the amount of Gadd45gamma.
| 4
Modified SCN1A decreases the amount of Gadd45gamma. 3 / 3
| 3
reach
"Furthermore, silencing NAC-1 expression or disrupting NAC-1 homodimerization by a dominant negative NAC-1 protein that contained only the BTB/POZ domain induced the expression of Gadd45gamma, which interacted with Gadd45gip1."
19305429
reach
"Thus, the findings based on both NAC-1 knockdown and N130 mut approaches indicated that NAC-1 expression and homodimerization were essential to suppress Gadd45gamma expression."
19305429
reach
"Furthermore, silencing NAC-1 expression or disrupting NAC-1 homodimerization by a dominant negative NAC-1 protein that contained only the BTB/POZ domain induced expression of Gadd45gamma which interacted with Gadd45gip1."
19305429
SCN1A decreases the amount of Gadd45gamma. 1 / 1
| 1
reach
"In the current report and our previous study, we have demonstrated that NAC-1 proteins negatively regulate the expression of Gadd45gip1 (Crif1) and Gadd45gamma."
19305429
SCN1A increases the amount of Gadd45gamma.
| 2
SCN1A increases the amount of Gadd45gamma. 2 / 2
| 2
reach
"Furthermore, silencing NAC-1 expression or disrupting NAC-1 homodimerization by a dominant negative NAC-1 protein that contained only the BTB/POZ domain induced expression of Gadd45gamma which interacted with Gadd45gip1."
19305429
reach
"Furthermore, silencing NAC-1 expression or disrupting NAC-1 homodimerization by a dominant negative NAC-1 protein that contained only the BTB/POZ domain induced the expression of Gadd45gamma, which interacted with Gadd45gip1."
19305429
Sodium_channels affects SCN1A
| 5
Sodium_channels binds SCN1A. 4 / 4
| 4
sparser
"Furthermore, alternative splicing of a sodium channel gene, SCN1A , has also recently been associated with altered response to antiepileptic medications [ xref ]."
17343748
sparser
"Recently, different rescuing approaches have been explored to increase surface expression and restore the correct functioning of sodium channel mutants associated to GEFS+ and SMEI that present folding defects in vitro ( xref )."
27242528
sparser
"FEB3 and FEB8 are associated with mutations in the sodium channel ( SCN1A ) and gamma-amino butyric acid (GABA) receptor ( GABRG2 ) genes, respectively, which cause fever-related epileptic syndromes (e.g., generalized epilepsy with FS plus and severe myoclonic epilepsy of infancy)."
19854014
sparser
"Sanjay Sisodiya (University College London, UK) presented data showing that mutation of the gene SCN1A , which encodes a sodium channel, is associated with drug-resistant forms of epilepsy."
18492225
Sodium_channels binds Voltage_gated_ion_channels, SCN1A, and SCN2A. 1 / 1
| 1
sparser
"Mutations in the neuronal voltage-gated sodium channel genes SCN1A and SCN2A are associated with inherited epilepsies, including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (severe myoclonic epilepsy of infancy)."
21156207
AntagoNAT affects SCN1A
| 5
AntagoNAT activates SCN1A.
| 4
AntagoNAT activates SCN1A. 4 / 4
| 4
reach
"Taken together, our results demonstrate that at least some of the major aspects of Dravet are likely to be caused by persistent SCN1A deficit after birth and can be improved by AntagoNAT mediated upregulation of SCN1A."
27333023
reach
"Overall, these results indicate that AntagoNAT mediated inhibition of SCN1ANAT results in the upregulation of SCN1A regardless of the SCN1A mutation type, thus increasing potential applicability of the AntagoNAT method in the treatment of Dravet syndrome and other diseases caused by de-novo mutations."
27333023
reach
"Taken together, these experiments demonstrated that AntagoNAT mediated increase of Scn1a in adult Dravet mice (Scn1a E1099X/+) can improve spontaneous seizure phenotype."
27333023
reach
"While AntagoNAT treatment upregulated SCN1A, it did not affect> 90% of all expressed genes, including other highly homologous sodium channel subunits and genes immediately adjacent to SCN1A on the chromosome (XREF_FIG; XREF_SUPPLEMENTARY)."
27333023
AntagoNAT increases the amount of SCN1A.
| 1
AntagoNAT increases the amount of SCN1A. 1 / 1
| 1
reach
"The increased expression of these genes could occur as a downstream effect of the AntagoNAT mediated increase of SCN1A expression."
27333023
Sodium(1+) affects SCN1A
| 4
Sodium(1+) inhibits SCN1A.
| 2
Sodium(1+) inhibits SCN1A. 2 / 2
| 2
reach
"We conclude that SMEI is caused either by complete loss of SCN1A function, or by dysfunctional sodium channels exhibiting mixed biophysical properties."
17054685
reach
"Identification of a precise genetic etiology can direct physicians to (i) prescribe treatments that correct specific metabolic defects (e.g., the ketogenic diet for GLUT1 deficiency, or pyridoxine for pyridoxine dependent epilepsies); (ii) avoid antiepileptic drugs (AEDs) that can aggravate the pathogenic defect (e.g., sodium channel blocking drugs in SCN1A related Dravet syndrome), or (iii) select AEDs that counteract the functional disturbance caused by the gene mutation (e.g., sodium channel blockers for epilepsies due to gain-of-function SCN8A mutations)."
30870728
Sodium(1+) activates SCN1A.
| 2
Sodium(1+) activates SCN1A. 2 / 2
| 2
reach
"This condition is genetically heterogeneous, with mutations in the KCNT1 gene that codes for a sodium activated potassium channel and mutations in SCN1A both described."
26558925
reach
"By contrast, lamotrigine, a widely used sodium channel blocking antiepileptic drug, caused Scn1a +/- mice to exhibit a higher seizure frequency consistent with observations made in human Dravet syndrome 12."
28490751
Clobazam affects SCN1A
| 4
Clobazam activates SCN1A. 4 / 4
| 4
reach
"Following induction of a single hyperthermic seizure, Scn1a +/- mice were subchronically treated with clobazam and stiripentol (160 mg per kg of chow and 4000 mg per kg of chow, respectively)."
28491900
reach
"Following induction of a single, brief thermal seizure, we counted subsequent unprovoked GTCS in Scn1a +/- mice subchronically treated with valproic acid, clobazam, or stiripentol using doses that targeted the human therapeutic range."
28491900
reach
"Scn1a +/- mice treated with clobazam at doses corresponding to the human therapeutic range had an increased temperature threshold for hyperthermia induced seizures and reduced spontaneous seizure frequency compared to controls XREF_BIBR, XREF_BIBR."
29127345
reach
"In our studies, threshold temperature for hyperthermia induced seizures was elevated in Scn1a +/- mice treated with supratherapeutic levels of clobazam, while lower doses did not provide significant protection from hyperthermia induced seizures or premature death."
27768696
SCN1A affects GEFS+
| 4
SCN1A activates GEFS+. 3 / 3
| 3
reach
"Since we wanted a model system to study the mechanism by which SCN1A missense mutations lead to GEFS+, we constructed transgenic mice using a BAC clone containing the complete mouse Scn1a gene."
19409490
reach
"SCN1A (Na V 1.1 sodium channel) mutations cause Dravet syndrome (DS) and GEFS+ (which is in general milder), and are risk factors in other epilepsies."
30659983
reach
"Rare mutations in SCN1A cause a wide spectrum of epilepsy syndromes, including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (DS, also known as severe myoclonic epilepsy of infancy) 5, depending on the nature of the mutation and possible genetic modifiers on other genes 30."
25344690
Mutated SCN1A activates GEFS+. 1 / 1
| 1
reach
"Careful analysis of the spatial and temporal distribution of Na v 1.1, its splice isoforms and its regulation will be necessary to better understand how SCN1A mutations lead to GEFS+."
19409490
SCN1A affects FST
| 1 3
SCN1A binds FST.
| 1 1
SCN1A binds FST. 1 / 1
| 1
reach
"Another study conducted among Chinese children in Taiwan did not find any association between FS and SCN1A SNP rs2298771 (Chou et al., 2003)."
22578703
SCN1A binds FST and GABRG2. 1 / 1
| 1
sparser
"Among all the epilepsy genes, mutations in SCN1A and GABRG2 have been strongly associated with FS and extended epilepsy syndromes like generalized epilepsy with febrile plus (GEFS+) and Dravet syndrome xref ā€“ xref ."
28505490
SCN1A activates FST.
| 2
SCN1A activates FST. 1 / 1
| 1
reach
"Although our inability to find an association in the sub-group analysis might be due to the relatively small number of patients in the MTLE-HS-FS + (138 patients) and MTLE-HS-FS - (65 patients) sub-groups, positive results we obtained when these sub-groups were independently compared with the controls argue against such an assumption.Based on the above results, we conclude that SCN1A SNP rs3812718 does not contribute significantly to susceptibility to FS in South Indian population."
22578703
Mutated SCN1A activates FST. 1 / 1
| 1
reach
"Our findings illustrate that SCN1A mutations can cause simple FS associated with TLE, which differ from the characteristic clinical spectrum of GEFS+."
17565594
SCN1A affects FHM3
| 4
SCN1A activates FHM3. 3 / 3
| 3
reach
"FHM1, FHM2 and FHM3 are caused by mutations in the ion-channel genes CACNA1A, ATP1A2 and SCN1A, respectively [XREF_BIBR - XREF_BIBR]."
18846413
reach
"Until now, only eight SCN1A missense mutations have been described to cause FHM3."
26763045
reach
"FHM is a genetically heterogeneous disease, in which mutations can occur in the ion transportation genes CACNA1A, ATP1A2, and SCN1A, promoting the different types of familial migraines, FHM1, FHM2 and FHM3."
27313535
Mutated SCN1A activates FHM3. 1 / 1
| 1
reach
"FHM is classified into 3 types : FHM1, which is caused by CACNA1A mutations on chromosome 19p13, FHM2, caused by ATP1A2 mutations on chromosome 1q21-23, and FHM3, caused by SCN1A mutations on chromosome 2q24 [XREF_BIBR, XREF_BIBR]."
25969684
SCN1A affects ATP1A2
| 3 1
SCN1A binds ATP1A2.
| 3
SCN1A binds ATP1A2. 1 / 1
| 1
sparser
"It is the only migraine disorder where pathogenetic mutations are known, since it is associated with mutations in the CANA1A, ATP1A2, and SCN1A genes [ xref ]."
24396618
SCN1A binds CACNA1A and ATP1A2. 1 / 1
| 1
sparser
"FHM may be associated with mutations in the genes CACNA1A (FHM1), ATP1A2 (FHM2) and SCN1A (FHM3) [ xref ]."
22661290
SCN1A binds CACNA1A, ATP1A2, and ATP1A2. 1 / 1
| 1
sparser
"Mutations in CACNA1A, ATP1A2 and SCN1A genes have been associated with familial hemiplegic migraine (FHM), a rare monogenic form of migraine [ xref ]."
23566281
SCN1A activates ATP1A2.
| 1
SCN1A activates ATP1A2. 1 / 1
| 1
reach
"In FHM type 1 the affected gene is CACNA1A (chromosome 19p13), coding for a P/Q calcium channel [XREF_BIBR], in FHM type 2 the ATP1A2 gene (chromosome 1q23) is affected, encoding a subunit of the Na + / K + -ATPase [XREF_BIBR], and FHM type 3 is caused by variants in the SCN1A gene (chromosome 2q24), coding for a sodium channel [XREF_BIBR]."
22072275
SCN1A affects Reactive Oxygen Species
| 3
SCN1A inhibits Reactive Oxygen Species. 2 / 2
| 2
reach
"Treatment with (PhSe) 2 or NAC 1 h after the APAP dose diminished the TBARS and ROS generation to a level comparable to the control levels (XREF_TABLE)."
24349162
reach
"Except 1 mm DHA, the antioxidants reduced ROS at 4 h. Moreover, NAC 1 mm, rutin and TEMPOL reduced ROS and DNA damage in the presence of oxidative stress."
22372742
SCN1A activates Reactive Oxygen Species. 1 / 1
| 1
reach
"To test the potential role for ROS, B16.SIY cells were treated with 3 mM NAC 1 hour prior to cephalexin or amoxicillin as a positive control [XREF_BIBR, XREF_BIBR] +/- 6 Gy and examined by comet assay after 24 hours."
27129153
SCN1A affects RORA
| 3
RORA binds SCN1A. 3 / 3
| 3
sparser
"RORA rs12912233 and SCN1A rs3812718 with synergy interaction were located on the same branch, whereas RORA rs880626 was located on a different branch, hence indicating the strongest synergy interaction with RORA rs12912233 and SCN1A rs3812718 polymorphisms ( Fig.Ā 3 B)."
25668517
sparser
"There was a high-synergy redundancy interaction between RORA rs12912233 and SCN1A rs3812718 (interaction entropy of 0.32%) and between RORA rs880626 and RORB rs3750420 (interaction entropy of 0.17%), whereas the redundancy interaction between other peer loci was negative (interaction entropy more than āˆ’ 0.05%) ( Fig.Ā 3 A )."
25668517
sparser
"In conclusion, our caseā€“control study suggests that RORA rs12912233 alone, or in interaction with RORA rs880626 and SCN1A rs3812718, might be a risk variant for susceptibility to epilepsy."
25668517
SCN1A affects FHM
| 3
SCN1A activates FHM. 2 / 2
| 2
reach
"So far, mutations in three different genes, CACNA1A, ATP1A2, and SCN1A, have been described to cause FHM and they are referred as FHM1, FHM2, and FHM3, respectively."
29867740
reach
"Gene mutations of CACNA1A, SCN1A, and ATP1A2 can cause FHM and we investigated only CACNA1A gene mutation in the present case that revealed negative result."
28101483
Mutated SCN1A activates FHM. 1 / 1
| 1
reach
"Among these, SCN1A encodes the voltage gated Na + channel Nav1.1, and FHM caused by mutations of SCN1A is named FHM3."
31730442
SCN1A affects ABCB1
| 2 1
SCN1A binds ABCB1. 1 / 1
| 1
reach
"We did not observe any significant associations between ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA or BAG6 genes and CBZ dose or dose adjusted concentration in CBZ-tolerant patients."
24861996
SCN1A binds ABCB1 and GABRG2. 1 / 1
| 1
sparser
"Functionally significant association of drug target genes such as GABRG2 and SCN1A and efflux transporter gene ABCB1 to susceptibility to epilepsy in the present population needs to be seen in combination rather than isolation in evaluating therapeutic response."
24586633
SCN1A binds UGT2B7, CYP2C19, CYP2C9, and ABCB1. 1 / 1
| 1
sparser
"The primary goals of this study were the following: (i) to analyze the association between several single nucleotide polymorphisms (SNPs) of the CYP2C9, CYP2C19, UGT2B7, ABCB1, and SCN1A genes by bivariate analysis and (ii) to analyze these associations taking into account some factors related with the patient and his/her epilepsy by multivariate analysis."
20064729
RORA affects SCN1A
| 3
RORA binds SCN1A. 3 / 3
| 3
sparser
"RORA rs12912233 and SCN1A rs3812718 with synergy interaction were located on the same branch, whereas RORA rs880626 was located on a different branch, hence indicating the strongest synergy interaction with RORA rs12912233 and SCN1A rs3812718 polymorphisms ( Fig.Ā 3 B)."
25668517
sparser
"There was a high-synergy redundancy interaction between RORA rs12912233 and SCN1A rs3812718 (interaction entropy of 0.32%) and between RORA rs880626 and RORB rs3750420 (interaction entropy of 0.17%), whereas the redundancy interaction between other peer loci was negative (interaction entropy more than āˆ’ 0.05%) ( Fig.Ā 3 A )."
25668517
sparser
"In conclusion, our caseā€“control study suggests that RORA rs12912233 alone, or in interaction with RORA rs880626 and SCN1A rs3812718, might be a risk variant for susceptibility to epilepsy."
25668517
RACK1 affects SCN1A
| 3 3
RACK1 increases the amount of SCN1A.
| 1 2
RACK1 increases the amount of SCN1A. 1 / 1
| 1 1
reach
"Knocking-down RACK1 in NT2 cells markedly increased SCN1A mRNA levels."
26503606
Modified RACK1 increases the amount of SCN1A. 1 / 1
| 1
reach
"Knockdown of RACK1 expression in NT2 cells deprived the repressive role of the silencer on the P1c promoter and increased SCN1A transcription, suggesting the potential involvement of RACK1 in negatively regulating SCN1A transcription via interaction with the silencer."
24436055
RACK1 decreases the amount of SCN1A.
| 2 1
RACK1 decreases the amount of SCN1A. 1 / 1
| 2 1
reach
"Transcription of the human sodium channel SCN1A gene is repressed by a scaffolding protein RACK1."
24436055
NOVA2 affects SCN1A
| 3
NOVA2 activates SCN1A.
| 2
NOVA2 activates SCN1A. 2 / 2
| 2
reach
"Although no NOVA2 -mediated modulation of SCN1A exon 5 splicing was detected when all subjects were evaluated, a statistically significant correlation (uncorrected for multiple testing) was observed in human brain tissue between NOVA2 mRNA expression and the percentage of SCN1A transcripts containing exon 5N for the AA genotype."
17436242
reach
"Overall, this translated into Nova2 increasing the percentage of SCN1A transcripts containing exon 5N."
17436242
NOVA2 inhibits SCN1A.
| 1
NOVA2 inhibits SCN1A. 1 / 1
| 1
reach
"However, increasing Nova2 decreased the quantity of SCN1A transcripts containing the adult form of exon 5 while it simultaneously increased the number of transcripts containing the neonatal form."
17436242
NAV1 affects SCN1A
| 2 1
NAV1 binds SCN1A.
| 2
SCN1A binds NAV1. 2 / 2
| 2
sparser
"A recent report of 9 patients with an early profound form of SMEI xref reported one patient with an Nav1.1-p."
29466837
sparser
"Mutations of the gene SCN1A (which encodes Nav1.1) in the nervous system have been associated with human inherited epileptic syndromes and familial hemiplegic migraine, suggesting that Nav1.1 might participate in the genesis of migraine ( xref ; xref )."
21714116
NAV1 activates SCN1A.
| 1
NAV1 activates SCN1A. 1 / 1
| 1
reach
"This appears to be a case in which a channelopathy produces an interneuronopathy since NaV1.1 (the protein product of Scn1a) is localized to the axon initial segments of parvalbumin positive (Pv +) fast spiking and Somatostatin positive (SST) interneurons in the neocortex and hippocampus, as well as to purkinje neurons of the cerebellum, which also exhibit fast spiking behavior."
26291155
ATP1A2 affects SCN1A
| 3
SCN1A binds ATP1A2. 1 / 1
| 1
sparser
"It is the only migraine disorder where pathogenetic mutations are known, since it is associated with mutations in the CANA1A, ATP1A2, and SCN1A genes [ xref ]."
24396618
SCN1A binds CACNA1A and ATP1A2. 1 / 1
| 1
sparser
"FHM may be associated with mutations in the genes CACNA1A (FHM1), ATP1A2 (FHM2) and SCN1A (FHM3) [ xref ]."
22661290
SCN1A binds CACNA1A, ATP1A2, and ATP1A2. 1 / 1
| 1
sparser
"Mutations in CACNA1A, ATP1A2 and SCN1A genes have been associated with familial hemiplegic migraine (FHM), a rare monogenic form of migraine [ xref ]."
23566281
ABCB1 affects SCN1A
| 2 1
SCN1A binds ABCB1. 1 / 1
| 1
reach
"We did not observe any significant associations between ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA or BAG6 genes and CBZ dose or dose adjusted concentration in CBZ-tolerant patients."
24861996
SCN1A binds ABCB1 and GABRG2. 1 / 1
| 1
sparser
"Functionally significant association of drug target genes such as GABRG2 and SCN1A and efflux transporter gene ABCB1 to susceptibility to epilepsy in the present population needs to be seen in combination rather than isolation in evaluating therapeutic response."
24586633
SCN1A binds UGT2B7, CYP2C19, CYP2C9, and ABCB1. 1 / 1
| 1
sparser
"The primary goals of this study were the following: (i) to analyze the association between several single nucleotide polymorphisms (SNPs) of the CYP2C9, CYP2C19, UGT2B7, ABCB1, and SCN1A genes by bivariate analysis and (ii) to analyze these associations taking into account some factors related with the patient and his/her epilepsy by multivariate analysis."
20064729
Serotonin affects SCN1A
| 2
Serotonin inhibits SCN1A.
| 1
Serotonin inhibits mutated SCN1A. 1 / 1
| 1
reach
"Similarly, the 5-HT 2C -agonist (Ro 600175) decreased locomotor activity of scn1a mutant but also of the WT larvae."
28428755
Serotonin activates SCN1A.
| 1
Serotonin activates mutated SCN1A. 1 / 1
| 1
reach
"An adult woman with Dravet syndrome (documented SCN1A mutation) experienced a marked reduction in seizures when treated with the selective serotonin reuptake inhibitor (SSRI) fluoxetine."
24955329
Phorbol 13-acetate 12-myristate affects SCN1A
| 2
Phorbol 13-acetate 12-myristate inhibits SCN1A. 1 / 1
| 1
reach
"We found that knockdown of KDM5B inhibited TPA mediated repression of SCN1A and ITPR1 (XREF_FIG)."
20832725
Phorbol 13-acetate 12-myristate decreases the amount of SCN1A.
| 1
Phorbol 13-acetate 12-myristate decreases the amount of SCN1A. 1 / 1
| 1
reach
"We considered the possibility that TPA dependent signaling might inhibit the expression of SCN1A and ITPR1 by blocking the localization and/or function of PARP-1 at their promoters."
20832725
MiR164 affects SCN1A
| 2
MiR164 inhibits SCN1A.
| 1
MiR164 inhibits SCN1A. 1 / 1
| 1
reach
"Additionally, auxin signal is also known to regulate miR164 expression, which down-regulates the NAC1 transcription factor during LR initiation."
19969544
MiR164 activates SCN1A.
| 1
MiR164 activates SCN1A. 1 / 1
| 1
reach
"MiR164 mediates the cleavage of NAC1 (AT1G56010) and NAC2 (AT5G39610), which were involved in the processes of lateral root emergence and aging induced cell death and leaf senescence, respectively XREF_BIBR XREF_BIBR."
28422166
Lamotrigine affects SCN1A
| 2
Lamotrigine activates SCN1A. 2 / 2
| 2
reach
"By contrast, lamotrigine, a widely used sodium channel blocking antiepileptic drug, caused Scn1a +/- mice to exhibit a higher seizure frequency consistent with observations made in human Dravet syndrome 12."
28490751
reach
"Specifically, Scn1a +/- mice treated with lamotrigine (20mg/kg/day) beginning at age P18 exhibited significantly more spontaneous seizures during a video monitored period between P21 and P25 (223 seizures over 863hours, n = 9) than control animals (75 seizures over 958hours, n = 14, p = 0.0047)."
28490751
Gamma-aminobutyric acid affects SCN1A
| 2
Gamma-aminobutyric acid inhibits SCN1A. 1 / 1
| 1
reach
"34-36 Based on these findings and our mortality results, we speculate that a lower level of endogenous GABA neurotransmission in females may contribute to comprise GABA interneuron function in Scn1a +/- mice, thereby tipping the balance toward elevated incidence of SUDEP."
31830809
Gamma-aminobutyric acid activates SCN1A. 1 / 1
| 1
reach
"In addition, increasing GABA signalling by application of the positive allosteric GABA A receptor modulator clonazepam was sufficient to rescue the abnormal social behaviour in Scn1a +/- mice 181."
29375819
Cas9 affects SCN1A
| 2
Cas9 increases the amount of SCN1A.
| 1
Cas9 increases the amount of SCN1A. 1 / 1
| 1
reach
"We designed a CRISPR based gene therapy for Scn1a-haplodeficient mice using multiple guide RNAs (gRNAs) in the promoter regions together with the nuclease deficient Cas9 fused to transcription activators (dCas9-VPR) to trigger the transcription of SCN1A or Scn1a in vitro."
32445790
Cas9 activates SCN1A.
| 1
Cas9 activates SCN1A. 1 / 1
| 1
reach
"Here we tested whether catalytically dead Cas9 (dCas9)-mediated Scn1a gene activation can rescue Scn1a haploinsufficiency in a mouse DS model and restore physiological levels of its gene product, the Na v 1.1 voltage gated sodium channel."
31607539
Captopril affects SCN1A
| 2
Captopril inhibits SCN1A.
| 1
Captopril inhibits SCN1A. 1 / 1
| 1
reach
"Immunoblotting showed that captopril had prevented the AD related down-regulation of hippocampal Scn1a, i.e., the sodium channel, voltage gated, type I, alpha (XREF_FIG)."
23959119
Captopril activates SCN1A.
| 1
Captopril activates SCN1A. 1 / 1
| 1
reach
"Moreover, captopril had promoted a significant increase in hippocampal Scn1a protein content over the level of 12 month-old Tg2576 mice (XREF_FIG)."
23959119
Beta2 ICD affects SCN1A
| 2
Beta2 ICD increases the amount of SCN1A.
| 1
Modified beta2 ICD increases the amount of SCN1A. 1 / 1
| 1
reach
"The beta2 ICD translocates to the nucleus and increases Scn1a expression, suggesting that this fragment may function as a transcriptional regulator of VGSC alpha subunits [XREF_BIBR]."
20600605
Beta2 ICD activates SCN1A.
| 1
Beta2 ICD activates SCN1A. 1 / 1
| 1
reach
"The beta2 ICD released by sequential BACE1 and gamma-secretase cleavage localizes to the nucleus and increases SCN1A mRNA and Na v 1.1 protein levels, suggesting that the cleaved beta2 ICD may function as a transcription regulator."
18940784
TNF affects SCN1A
2 |
TNF increases the amount of SCN1A.
1 |
Transcriptionally active TNF increases the amount of SCN1A. 1 / 1
1 |
signor
"TNF-Ī± increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-ĪŗB and p38 MAPK signal pathways in CNS neurons. TNF-Ī± increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels."
26112872
TNF activates SCN1A.
1 |
TNF activates SCN1A. 1 / 1
1 |
signor
"TNF-Ī± increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-ĪŗB and p38 MAPK signal pathways in CNS neurons. TNF-Ī± increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels."
26112872
Sudden Infant Death affects SCN1A
| 1 1
SCN1A binds Sudden Infant Death. 2 / 2
| 1 1
sparser
"The novel association of SCN1A with SIDS supports further intense efforts to understand epilepsy-related mechanisms into sudden death across the age spectrum in individuals with and without an overt history of seizures or epilepsy."
29601086
reach
"Our cases represent a novel association between SCN1A and SIDS, extending the SCN1A spectrum from epilepsy to SIDS."
29601086
SNTA1 affects SCN1A
2 |
SCN1A binds SNTA1. 2 / 2
2 |
biogrid
No evidence text available
9412493
biogrid
No evidence text available
9412493
SNP affects SCN1A
| 2
SCN1A binds SNP. 2 / 2
| 2
sparser
"In addition, in the Caucasian population, Schlachter et al. found an association between SNP rs3812718 of SCN1A and febrile seizures (FS) [16] ."
21531204
sparser
"In the phase 1 sample, SNP rs6731900 located 1ā€‰kb 5ā€² to the TTC21B gene (encoding tetratricopeptide repeat domain 21B) and 103ā€‰kb 3ā€² to SCN1A SNP rs10930201 was also significantly (that is, FDR-corrected) associated with immediate recall performance ( xref )."
20038948
SCN1ANAT affects SCN1A
| 2
SCN1ANAT increases the amount of SCN1A.
| 1
SCN1ANAT increases the amount of SCN1A. 1 / 1
| 1
reach
"Taken together, the results from the 3 sets of experiments indicate that SCN1ANAT mediated increase of SCN1A expression does not result from spurious qualities of one AntagoNAT, non specific chemistry effect, generalized transcriptional upregulation or class effect involving all sodium channels."
27333023
SCN1ANAT activates SCN1A.
| 1
SCN1ANAT activates SCN1A. 1 / 1
| 1
reach
"While 86% of AntagoNATs designed against SCN1ANAT induced SCN1A upregulation at 20nM, the scale of upregulation was different (XREF_FIG)."
27333023
SCN1A affects apoptotic process
| 2
SCN1A inhibits apoptotic process.
| 1
SCN1A inhibits apoptotic process. 1 / 1
| 1
reach
"NAC-1 gene knockdown inhibited cell growth and induced apoptosis in HeLa, HeLa TG, and ME180 cells, all of which overexpressed NAC-1."
18347169
SCN1A activates apoptotic process.
| 1
SCN1A activates apoptotic process. 1 / 1
| 1
reach
"To further investigate whether FeNG induced ROS is required for induction of apoptosis, CEM and ADR5000 cells were treated with different concentrations of NAC 1 h prior to FeNG treatment and cell death and apoptosis was monitored by MTT assay and cell cycle analysis."
20582168
SCN1A affects Sudden Infant Death
| 1 1
SCN1A binds Sudden Infant Death. 2 / 2
| 1 1
sparser
"The novel association of SCN1A with SIDS supports further intense efforts to understand epilepsy-related mechanisms into sudden death across the age spectrum in individuals with and without an overt history of seizures or epilepsy."
29601086
reach
"Our cases represent a novel association between SCN1A and SIDS, extending the SCN1A spectrum from epilepsy to SIDS."
29601086
SCN1A affects SNTA1
2 |
SCN1A binds SNTA1. 2 / 2
2 |
biogrid
No evidence text available
9412493
biogrid
No evidence text available
9412493
SCN1A affects SNP
| 2
SCN1A binds SNP. 2 / 2
| 2
sparser
"In addition, in the Caucasian population, Schlachter et al. found an association between SNP rs3812718 of SCN1A and febrile seizures (FS) [16] ."
21531204
sparser
"In the phase 1 sample, SNP rs6731900 located 1ā€‰kb 5ā€² to the TTC21B gene (encoding tetratricopeptide repeat domain 21B) and 103ā€‰kb 3ā€² to SCN1A SNP rs10930201 was also significantly (that is, FDR-corrected) associated with immediate recall performance ( xref )."
20038948
SCN1A affects RESPONSIVENESS
| 2
SCN1A binds RESPONSIVENESS. 2 / 2
| 2
trips
"Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy."
32185219
trips
"Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy."
32185219
SCN1A affects FHM2
| 2
SCN1A activates FHM2. 2 / 2
| 2
reach
"FHM is a genetically heterogeneous disease, in which mutations can occur in the ion transportation genes CACNA1A, ATP1A2, and SCN1A, promoting the different types of familial migraines, FHM1, FHM2 and FHM3."
27313535
reach
"FHM1, FHM2 and FHM3 are caused by mutations in the ion-channel genes CACNA1A, ATP1A2 and SCN1A, respectively [XREF_BIBR - XREF_BIBR]."
18846413
SCN1A affects FHM1
| 2
SCN1A activates FHM1. 2 / 2
| 2
reach
"FHM1, FHM2 and FHM3 are caused by mutations in the ion-channel genes CACNA1A, ATP1A2 and SCN1A, respectively [XREF_BIBR - XREF_BIBR]."
18846413
reach
"FHM is a genetically heterogeneous disease, in which mutations can occur in the ion transportation genes CACNA1A, ATP1A2, and SCN1A, promoting the different types of familial migraines, FHM1, FHM2 and FHM3."
27313535
SCN1A affects DEPDC5
| 2
SCN1A binds DEPDC5. 1 / 1
| 1
sparser
"The identification of mutations in DEPDC5 and SCN1A in families showing heterogeneous phenotypic patterns enlarges the phenotypic spectrum of the epilepsies associated with these genes."
27066544
SCN1A binds CNTNAP2, DEPDC5, and EAF family. 1 / 1
| 1
sparser
"The association of EAF with CNTNAP2 , DEPDC5 , and SCN1A mutations widens the phenotypic spectrum related to these genes."
27066544
SCN1A affects CYP2C9
| 2
SCN1A binds CYP2C9. 1 / 1
| 1
sparser
"A 2005 study assessed whether variations in CYP2C9 and SCN1A were associated with the clinical use of carbamazepine (n = 425) and phenytoin (n = 281) [ xref ]."
22003912
SCN1A binds UGT2B7, CYP2C19, CYP2C9, and ABCB1. 1 / 1
| 1
sparser
"The primary goals of this study were the following: (i) to analyze the association between several single nucleotide polymorphisms (SNPs) of the CYP2C9, CYP2C19, UGT2B7, ABCB1, and SCN1A genes by bivariate analysis and (ii) to analyze these associations taking into account some factors related with the patient and his/her epilepsy by multivariate analysis."
20064729
RESPONSIVENESS affects SCN1A
| 2
SCN1A binds RESPONSIVENESS. 2 / 2
| 2
trips
"Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy."
32185219
trips
"Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy."
32185219
NOG affects SCN1A
2 |
Transcriptionally active NOG increases the amount of SCN1A. 2 / 2
2 |
biopax:ctd
No evidence text available
27188386
biopax:ctd
No evidence text available
27188386
NEDD4L affects SCN1A
2 |
NEDD4L ubiquitinates SCN1A.
1 |
NEDD4L ubiquitinates SCN1A. 1 / 1
1 |
signor
"The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2)."
23778145
NEDD4L decreases the amount of SCN1A.
1 |
NEDD4L decreases the amount of SCN1A. 1 / 1
1 |
signor
"The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2)."
23778145
MAPT affects SCN1A
| 2
MAPT inhibits SCN1A. 2 / 2
| 2
reach
"Tau ablation reduced the percentage of Scn1a RX/+ mice with seizures 2.7-fold to 16% without affecting seizure severity or duration in those mice that did develop seizures."
25042160
reach
"Tau Reduction Lowers Epileptic Activity and Network Hyperexcitability in Scn1a RX/+ Mice."
25042160
GS967 affects SCN1A
| 2
GS967 activates SCN1A. 2 / 2
| 2
reach
"A plausible explanation for normalization of pyramidal neuron sodium current density in Scn1a +/- mice chronically treated with GS967 is a change in the levels of sodium channel proteins."
28490751
reach
"Unexpectedly, Scn1a +/- mice treated with GS967 survived significantly longer than untreated Scn1a +/- littermates."
28490751
FST affects SCN1A
| 1 1
SCN1A binds FST. 1 / 1
| 1
reach
"Another study conducted among Chinese children in Taiwan did not find any association between FS and SCN1A SNP rs2298771 (Chou et al., 2003)."
22578703
SCN1A binds FST and GABRG2. 1 / 1
| 1
sparser
"Among all the epilepsy genes, mutations in SCN1A and GABRG2 have been strongly associated with FS and extended epilepsy syndromes like generalized epilepsy with febrile plus (GEFS+) and Dravet syndrome xref ā€“ xref ."
28505490
FGF14 affects SCN1A
2 |
FGF14 inhibits SCN1A.
1 |
FGF14 inhibits SCN1A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF14 binds SCN1A.
1 |
SCN1A binds FGF14. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF13 affects SCN1A
2 | 1
FGF13 inhibits SCN1A.
1 |
FGF13 inhibits SCN1A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF13 binds SCN1A.
1 | 1
SCN1A binds FGF13. 1 / 1
1 | 1
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF12 affects SCN1A
2 |
FGF12 inhibits SCN1A.
1 |
FGF12 inhibits SCN1A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF12 binds SCN1A.
1 |
SCN1A binds FGF12. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF11 affects SCN1A
2 |
FGF11 inhibits SCN1A.
1 |
FGF11 inhibits SCN1A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF11 binds SCN1A.
1 |
SCN1A binds FGF11. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
DEPDC5 affects SCN1A
| 2
SCN1A binds DEPDC5. 1 / 1
| 1
sparser
"The identification of mutations in DEPDC5 and SCN1A in families showing heterogeneous phenotypic patterns enlarges the phenotypic spectrum of the epilepsies associated with these genes."
27066544
SCN1A binds CNTNAP2, DEPDC5, and EAF family. 1 / 1
| 1
sparser
"The association of EAF with CNTNAP2 , DEPDC5 , and SCN1A mutations widens the phenotypic spectrum related to these genes."
27066544
CYP2C9 affects SCN1A
| 2
SCN1A binds CYP2C9. 1 / 1
| 1
sparser
"A 2005 study assessed whether variations in CYP2C9 and SCN1A were associated with the clinical use of carbamazepine (n = 425) and phenytoin (n = 281) [ xref ]."
22003912
SCN1A binds UGT2B7, CYP2C19, CYP2C9, and ABCB1. 1 / 1
| 1
sparser
"The primary goals of this study were the following: (i) to analyze the association between several single nucleotide polymorphisms (SNPs) of the CYP2C9, CYP2C19, UGT2B7, ABCB1, and SCN1A genes by bivariate analysis and (ii) to analyze these associations taking into account some factors related with the patient and his/her epilepsy by multivariate analysis."
20064729
ATP1A2 affects CACNA1A, and SCN1A
| 2
SCN1A binds CACNA1A and ATP1A2. 1 / 1
| 1
sparser
"FHM may be associated with mutations in the genes CACNA1A (FHM1), ATP1A2 (FHM2) and SCN1A (FHM3) [ xref ]."
22661290
SCN1A binds CACNA1A, ATP1A2, and ATP1A2. 1 / 1
| 1
sparser
"Mutations in CACNA1A, ATP1A2 and SCN1A genes have been associated with familial hemiplegic migraine (FHM), a rare monogenic form of migraine [ xref ]."
23566281
Tetrodotoxin affects SCN1A
| 1
Tetrodotoxin binds SCN1A. 1 / 1
| 1
reach
"It is known that SCN1A (Smith et al., 1998), SCN2A (Noda et al., 1986; Suzuki et al., 1988; Smith et al., 1998), SCN3A (Suzuki et al., 1988), and SCN8A (Smith et al., 1998) alpha subunits bind tetrodotoxin and STX with comparable affinities."
10827969
Specific AntagoNAT CUR-1916 affects SCN1A
| 1
Specific AntagoNAT CUR-1916 increases the amount of SCN1A. 1 / 1
| 1
reach
"A single IT injection of the human specific AntagoNAT CUR-1916 in saline vehicle induced dose dependent increase of Scn1a expression in the brain of African green monkeys (XREF_FIG c-f)."
27333023
Span affects SCN1A
| 1
Span increases the amount of SCN1A. 1 / 1
| 1
reach
"A problem with this proposed experimental strategy is that the short time span from disease onset to SUDEP in the Scn1a +/- mouse model on the (C57BL/6J x 129S6/SvEvTac) F1 strain may not allow sufficient time to reactivate Scn1a expression between disease onset and death."
30838929
Sodium chloride affects SCN1A
| 1
Sodium chloride activates SCN1A. 1 / 1
| 1
reach
"Here, a soybean (Glycine max) salinity induced NAC transcription factor encoded by SALT INDUCED NAC 1 (GmSIN1) was shown to be a key component of this process."
31227558
SiNAC1 affects SCN1A
| 1
SiNAC1 inhibits SCN1A. 1 / 1
| 1
reach
"Furthermore, Transwell assays demonstrated that down-regulation of NAC-1 by siNAC1 in DU-145 cells decreased the cell migration abilities compared with NC siRNA (XREF_FIG)."
29435019
Rhodium atom affects SCN1A
| 1
Rhodium atom activates SCN1A. 1 / 1
| 1
reach
"Our primary goal was to determine whether Scn1a dysfunction caused by the RH mutation alters sensitivity to cocaine induced behavioral and electrographic (EEG) seizures."
23494229
Plants affects SCN1A
| 1
Plants activates SCN1A. 1 / 1
| 1
reach
"Tobacco plants overexpressing finger millet NAC1 (EcNAC1) transcription factor showed lower lipid peroxidation due to the lower levels of MDA under abiotic stress conditions."
24868035
Phenytoin affects SCN1A
| 1
Phenytoin activates mutated SCN1A. 1 / 1
| 1
reach
"In contrast, phenytoin not only rescues a trafficking defective SCN1A mutant but also blocks the channel."
22961543
Inositol affects SCN1A
| 1
Inositol binds SCN1A. 1 / 1
| 1
reach
"Effects of normal aging and SCN1A risk gene expression on brain metabolites : evidence for an association between SCN1A and myo-inositol."
24357141
Icd affects SCN1A
| 1
Icd activates SCN1A. 1 / 1
| 1
reach
"In the case of beta2, the ICD increases Scn1a mRNA and Na v 1.1 protein levels."
19041953
HupA affects SCN1A
| 1
HupA activates mutated SCN1A. 1 / 1
| 1
reach
"The ability of Hup A to protect against hyperthermia induced seizures was evaluated in Scn1a mutant mice and their respective WT littermates."
27799911
Hsa-miR-933 affects SCN1A
1 |
Transcriptionally active hsa-miR-933 decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-93-3p affects SCN1A
1 |
Transcriptionally active hsa-miR-93-3p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-7161-5p affects SCN1A
1 |
Transcriptionally active hsa-miR-7161-5p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6867-5p affects SCN1A
1 |
Transcriptionally active hsa-miR-6867-5p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6756-3p affects SCN1A
1 |
Transcriptionally active hsa-miR-6756-3p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6749-3p affects SCN1A
1 |
Transcriptionally active hsa-miR-6749-3p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-576-5p affects SCN1A
1 |
Transcriptionally active hsa-miR-576-5p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-574-5p affects SCN1A
1 |
Transcriptionally active hsa-miR-574-5p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-548u affects SCN1A
1 |
Transcriptionally active hsa-miR-548u decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-548c-3p affects SCN1A
1 |
Transcriptionally active hsa-miR-548c-3p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-518b affects SCN1A
1 |
Transcriptionally active hsa-miR-518b decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-4799-5p affects SCN1A
1 |
Transcriptionally active hsa-miR-4799-5p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4783-5p affects SCN1A
1 |
Transcriptionally active hsa-miR-4783-5p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-4744 affects SCN1A
1 |
Transcriptionally active hsa-miR-4744 decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4668-3p affects SCN1A
1 |
Transcriptionally active hsa-miR-4668-3p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4509 affects SCN1A
1 |
Transcriptionally active hsa-miR-4509 decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4263 affects SCN1A
1 |
Transcriptionally active hsa-miR-4263 decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3613-3p affects SCN1A
1 |
Transcriptionally active hsa-miR-3613-3p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3127-3p affects SCN1A
1 |
Transcriptionally active hsa-miR-3127-3p decreases the amount of SCN1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Genotype affects SCN1A
| 1
SCN1A binds genotype. 1 / 1
| 1
sparser
"The results of this study confirmed the existence of a significant association of AG genotype and G allele of SCN1A c."
27498208
G. miR164 affects SCN1A
| 1
G. miR164 decreases the amount of SCN1A. 1 / 1
| 1
reach
"Its expression level also showed a gradual increase from the 7 th to the 9 th internode in both inbred lines, and NAC1 was negatively regulated by miR164a-d, and g. miR164 might decrease the expression of NAC1 by responding to auxin signaling, thereby reducing the elongation and development of the different internodes of the same inbred lines."
27695059
Cre affects SCN1A
| 1
SCN1A binds cre. 1 / 1
| 1
sparser
"In the social interaction test, Dlx1/2 - Scn1a +/āˆ’ mice spent less time interacting with the caged stranger mouse compared to Cre-negative Scn1a loxp /+mice ( xref )."
22914087
Cocaine affects SCN1A
| 1
Cocaine activates SCN1A. 1 / 1
| 1
reach
"These data suggest that the induction of NAC-1 by cocaine may be a compensatory mechanism that minimizes the behavioral impact of cocaine administration by regulating postsynaptic dopamine transmission within the nucleus accumbens."
10400893
Cisplatin affects SCN1A
| 1
Cisplatin activates SCN1A. 1 / 1
| 1
reach
"NAC-1 knockdown experiments in ovarian cancer cell lines treated with cisplatin resulted in a reduction of cisplatin and HMGB1 induced autophagy and an increase in cytotoxicity of ovarian cancer cells."
29254158
Ceramide affects SCN1A
1 |
Ceramide increases the amount of SCN1A. 1 / 1
1 |
bel
"Table 3 Known genes differentially expressed in ceramide-dependent apoptosis with no identified direct interaction with the ceramide-dependent apoptosis process"
12186649
Beta2-CTF affects SCN1A
| 1
Beta2-CTF activates SCN1A. 1 / 1
| 1
reach
"For example, the beta2-CTF translocates to the nucleus and promotes Scn1a mRNA and protein expression when heterologously expressed in cultured neurons."
27252364
Beta2 intracellular domain affects SCN1A
| 1
Modified beta2 intracellular domain increases the amount of SCN1A. 1 / 1
| 1
reach
"The beta2 intracellular domain translocates to the nucleus of transfected SH-SY5Y cells and increases expression of SCN1A, suggesting that it may function, directly or indirectly, as a transcriptional regulator of VGSC alpha subunit expression."
22007171
beta-amyloid peptide affects SCN1A
| 1
Modified beta-amyloid peptide increases the amount of SCN1A. 1 / 1
| 1
reach
"An interesting example is the finding that overexpression of beta-amyloid peptide, the pathogenic amyloid forming fragment in Alzheimer 's disease, drives down Scn1a expression in cortical interneurons 43."
31904123
Auxin affects SCN1A
| 1
Auxin increases the amount of SCN1A. 1 / 1
| 1
reach
"Additionally, auxin induces NAC1 expression at a reduced level in leaves and stems [XREF_BIBR - XREF_BIBR]."
27695059
TALEN isogenic affects SCN1A
| 1
TALEN isogenic activates SCN1A. 1 / 1
| 1
reach
"Generation of D1-1 TALEN isogenic control cell line from Dravet syndrome patient iPSCs using TALEN mediated editing of the SCN1A gene."
29453127
ST8SIA2 affects SCN1A
| 1
SCN1A binds ST8SIA2. 1 / 1
| 1
reach
"It is known that SCN1A (Smith et al., 1998), SCN2A (Noda et al., 1986; Suzuki et al., 1988; Smith et al., 1998), SCN3A (Suzuki et al., 1988), and SCN8A (Smith et al., 1998) alpha subunits bind tetrodotoxin and STX with comparable affinities."
10827969
SINAT5 affects SCN1A
| 1
SINAT5 activates SCN1A. 1 / 1
| 1
reach
"SINAT5, which is an Arabidopsis homologue of the RING-finger Drosophila protein, is expressed in the vascular tissues of mature roots and can target NAC1 to down-regulate auxin signals in the plant cells."
19965904
SCN1A affects transport
| 1
SCN1A inhibits transport. 1 / 1
| 1
sparser
"Also, low-affinity iron transport is inhibited by NaC1 and amiloride, but is stimulated by KC1, RbCI, LiC1 and CsC1 [5,6]."
8679654
SCN1A affects tetrodotoxin
| 1
Tetrodotoxin binds SCN1A. 1 / 1
| 1
reach
"It is known that SCN1A (Smith et al., 1998), SCN2A (Noda et al., 1986; Suzuki et al., 1988; Smith et al., 1998), SCN3A (Suzuki et al., 1988), and SCN8A (Smith et al., 1998) alpha subunits bind tetrodotoxin and STX with comparable affinities."
10827969
SCN1A affects sleep
| 1
SCN1A activates sleep. 1 / 1
| 1
reach
"While Scn1a haploinsufficiency is known to cause sleep and circadian abnormalities, hyperactivity, autistic- and anxiety like behavior in mouse models, these comorbidities have not been previously investigated in a systematic way in scn1lab mutant zebrafish."
28812061
SCN1A affects inositol
| 1
Inositol binds SCN1A. 1 / 1
| 1
reach
"Effects of normal aging and SCN1A risk gene expression on brain metabolites : evidence for an association between SCN1A and myo-inositol."
24357141
SCN1A affects homeostatic process
| 1
SCN1A inhibits homeostatic process. 1 / 1
| 1
reach
"Moreover, our results show that mutation of one allele of Scn1a also dramatically impairs sleep homeostasis in DS mice, as assessed from the large reduction in the rebound of slow wave activity after sleep deprivation."
25766678
SCN1A affects genotype
| 1
SCN1A binds genotype. 1 / 1
| 1
sparser
"The results of this study confirmed the existence of a significant association of AG genotype and G allele of SCN1A c."
27498208
SCN1A affects gefS
| 1
Mutated SCN1A activates gefS. 1 / 1
| 1
reach
"Because GEFS + is caused by missense mutations of SCN1A, and Dravet syndrome is frequently associated with FS and temperature induced seizures, Dravet syndrome and GEFS + are considered to belong to the same disease spectrum that includes FS as the mildest phenotype (Hirose et al., 2002a, b, 2003, 2005)."
25194483
SCN1A affects fast spiking neurons
| 1
SCN1A activates fast spiking neurons. 1 / 1
| 1
eidos
"Previous studies suggest that the reduction of Nav1.1 expression leads to a decrease of fast spiking activity in inhibitory neurons ."
32377688
SCN1A affects expression
| 1
SCN1A activates expression. 1 / 1
| 1
sparser
"NAC1, a member of the NAC family, is induced by auxin and activates expression of two downstream auxin-responsive genes to promote lateral root development ( xref )."
25071810
SCN1A affects cut9
| 1
SCN1A inhibits cut9. 1 / 1
| 1
reach
"The cold sensitive scn1 and scn2 mutations, defective in late anaphase, can suppress the ts phenotype of cut9."
7798319
SCN1A affects cre
| 1
SCN1A binds cre. 1 / 1
| 1
sparser
"In the social interaction test, Dlx1/2 - Scn1a +/āˆ’ mice spent less time interacting with the caged stranger mouse compared to Cre-negative Scn1a loxp /+mice ( xref )."
22914087
SCN1A affects cocaine
| 1
SCN1A activates cocaine. 1 / 1
| 1
reach
"The augmentation in cocaine motor behavior produced by NAC-1 antisense pretreatment in the nucleus accumbens was not associated with increased dopamine release as estimated by microdialysis."
10400893
SCN1A affects cell population proliferation
| 1
SCN1A activates cell population proliferation. 1 / 1
| 1
reach
"Overexpressions of the NAC-1 gene stimulated cell proliferation in cervical carcinoma cells of the TCS, CaSki, and HeLa P3 lines, which do not have endogenous NAC-1 expression."
18347169
SCN1A affects cell migration
| 1
SCN1A inhibits cell migration. 1 / 1
| 1
reach
"Furthermore, Transwell assays demonstrated that down-regulation of NAC-1 by siNAC1 in DU-145 cells decreased the cell migration abilities compared with NC siRNA (XREF_FIG)."
29435019
SCN1A affects cell growth
| 1
SCN1A activates cell growth. 1 / 1
| 1
reach
"NAC-1 gene knockdown inhibited cell growth and induced apoptosis in HeLa, HeLa TG, and ME180 cells, all of which overexpressed NAC-1."
18347169
SCN1A affects cell differentiation
| 1
SCN1A activates cell differentiation. 1 / 1
| 1
reach
"Function of Hevea brasiliensis NAC1 in dehydration induced laticifer differentiation and latex biosynthesis."
27544199
SCN1A affects calcium(2+)
| 1
Mutated SCN1A activates calcium(2+). 1 / 1
| 1
reach
"The greater Ca (v) 2.1 currents caused by the R468Q CACNB4 mutation may increase the neurotransmitter release in the excitatory neurons under the condition of insufficient inhibitory neurons caused primarily by the SCN1A mutation."
18755274
SCN1A affects biosynthetic process
| 1
SCN1A activates biosynthetic process. 1 / 1
| 1
reach
"Function of Hevea brasiliensis NAC1 in dehydration induced laticifer differentiation and latex biosynthesis."
27544199
SCN1A affects beta-1 subunit
| 1
SCN1A inhibits beta-1 subunit. 1 / 1
| 1
reach
"Thus, deletion of one copy of Scn1a induced a downregulation of the auxiliary beta-1 subunit."
31830809
SCN1A affects behavior
| 1
SCN1A activates behavior. 1 / 1
| 1
eidos
"Aken together , these data demonstrate that a deficit in Nav1.1 alters the temporal coordination of neuronal firing in CA1 and impairs behaviors that rely on the integrity of this network ."
32377688
SCN1A affects autophagy
| 1
SCN1A activates autophagy. 1 / 1
| 1
reach
"Thus, the NAC1- mediated autophagy may be exploited as a new target for enhancing the efficacy of cisplatin against ovarian cancer and other types of malignancies."
21743489
SCN1A affects TTX-R I
| 1
SCN1A increases the amount of TTX-R I. 1 / 1
| 1
reach
"Here, we show that Scn1a haploinsufficiency leads to increased functional expression of TTX-R I Na in the heart."
24155976
SCN1A affects ST8SIA2
| 1
SCN1A binds ST8SIA2. 1 / 1
| 1
reach
"It is known that SCN1A (Smith et al., 1998), SCN2A (Noda et al., 1986; Suzuki et al., 1988; Smith et al., 1998), SCN3A (Suzuki et al., 1988), and SCN8A (Smith et al., 1998) alpha subunits bind tetrodotoxin and STX with comparable affinities."
10827969
SCN1A affects SPW-R
| 1
SCN1A inhibits SPW-R. 1 / 1
| 1
reach
"Here, in vivo electrophysiologic recordings of hippocampal local field potential (LFP) in both male and female mice demonstrate that Scn1a haploinsufficiency slows intrinsic ripple frequency and reduces the rate of SPW-R occurrence."
31537705
SCN1A affects SCN2A, Sodium_channels, and Voltage_gated_ion_channels
| 1
Sodium_channels binds Voltage_gated_ion_channels, SCN1A, and SCN2A. 1 / 1
| 1
sparser
"Mutations in the neuronal voltage-gated sodium channel genes SCN1A and SCN2A are associated with inherited epilepsies, including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (severe myoclonic epilepsy of infancy)."
21156207
SCN1A affects PbeDREB2A
| 1
SCN1A binds PbeDREB2A. 1 / 1
| 1
reach
"Both the Y2H and BiFC assays indicated that PbeNAC1 could interact with PbeDREB1 or PbeDREB2A."
28713394
SCN1A affects PbeDREB1
| 1
SCN1A binds PbeDREB1. 1 / 1
| 1
reach
"Both the Y2H and BiFC assays indicated that PbeNAC1 could interact with PbeDREB1 or PbeDREB2A."
28713394
SCN1A affects Panayiotopoulos syndrome 48
| 1
Mutated SCN1A activates Panayiotopoulos syndrome 48. 1 / 1
| 1
reach
"43 Although the pathogenetic role of SCN1A mutations is increasingly recognised in familial hemiplegic migraine, 44,45 the hypothesis that SCN1A mutations might also underlie other epileptic conditions (eg, West syndrome, 46 Rasmussen encephalitis, 47 and atypical Panayiotopoulos syndrome 48) should be further investigated.The triggering effect of hyperthermia is one of the most striking clues in SMEI."
18275929
SCN1A affects PUM2
| 1
SCN1A activates PUM2. 1 / 1
| 1
reach
"For known Pum2 targets such as Scn1a and Scn8a, we did not detect changes at the mRNA level in 5-month-old brains."
29046322
SCN1A affects PSEN1
1 |
SCN1A binds PSEN1. 1 / 1
1 |
biogrid
No evidence text available
21163940
SCN1A affects PCDH7
| 1
SCN1A binds PCDH7. 1 / 1
| 1
sparser
"One recently published study based on 8696 cases and 26,157 controls [ xref ] identified that SCN1A and PCDH7 are associated with epilepsy."
26690205
SCN1A affects NR4A2
| 1
SCN1A decreases the amount of NR4A2. 1 / 1
| 1
reach
"The results showed that Nurr1 mRNA expression in MN9D cells was specifically down-regulated by the vectors of pSC-N1 and pSC-N2, and the silencing effects were 62.3% and 45.6%, respectively."
16906336
SCN1A affects NE
| 1
SCN1A inhibits NE. 1 / 1
| 1
reach
"By inhibiting the NE promoting TFs, both of these Nac1- and Oct4 mediated actions favor the ME choice and Nac1 in particular, may play a central role."
26832399
SCN1A affects MICA
| 1
SCN1A binds MICA. 1 / 1
| 1
reach
"We did not observe any significant associations between ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA or BAG6 genes and CBZ dose or dose adjusted concentration in CBZ-tolerant patients."
24861996
SCN1A affects MDH2
| 1
SCN1A binds MDH2. 1 / 1
| 1
sparser
"In addition, we showed that the H 2 O 2 levels increased in the hippocampus of the seizure mice, and H 2 O 2 could promote the binding of MDH2 to the binding sites of Scn1a gene, whereas Ī²-mercaptoethanol decreased the binding capability, indicating an important effect of the seizure-induced oxidation on the MDH2-mediated downregulation of Scn1a expression."
28433711
SCN1A affects Hiss
| 1
SCN1A activates Hiss. 1 / 1
| 1
reach
"The Scn1a homozygous mutant rats are named as hyperthermia induced seizure susceptible (Hiss) rats."
25312505
SCN1A affects HRH1
| 1
SCN1A binds HRH1. 1 / 1
| 1
sparser
"It is interesting to note that NAB2, a GWAS gene, is predicted to interact with two of these novel genes HRH1 and SCN1A that are targeted by nervous system drugs."
27336055
SCN1A affects GAN
1 |
SCN1A binds GAN. 1 / 1
1 |
biogrid
No evidence text available
26460568
SCN1A affects GABAA receptor
| 1
SCN1A inhibits GABAA receptor. 1 / 1
| 1
reach
"Scn1a missense mutation impairs GABAA receptor mediated synaptic transmission in the rat hippocampus."
20707984
SCN1A affects FMH 1
| 1
SCN1A activates FMH 1. 1 / 1
| 1
reach
"Approaches to identified genes for monogenic subtypes migraine (e.g. Familial Hemiplegic Migraine - FHM) has been successful (CACNA1A, ATP1A2, SCN1A genes causing FMH 1, 2 and 3 respectively) [XREF_BIBR - XREF_BIBR]."
20579352
SCN1A affects FHM3 subtype
| 1
SCN1A activates FHM3 subtype. 1 / 1
| 1
reach
"The FHM3 subtype is caused by mutations in SCN1A, which is also the most frequent epilepsy gene encoding the voltage gated Na + channel Na V 1.1."
26763045
SCN1A affects FHM type 3
| 1
SCN1A activates FHM type 3. 1 / 1
| 1
reach
"FHM Type 2 is caused by mutations in the ATP1A2 gene and FHM type 3 is caused by mutations in the SCN1A gene encoding the Na + channel, voltage gated, type I, alpha subunit."
27199775
SCN1A affects FGF14
1 |
SCN1A binds FGF14. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN1A affects FGF13
1 | 1
SCN1A binds FGF13. 1 / 1
1 | 1
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN1A affects FGF12
1 |
SCN1A binds FGF12. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN1A affects FGF11
1 |
SCN1A binds FGF11. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN1A affects FAS
| 1
SCN1A binds FAS. 1 / 1
| 1
reach
"We did not observe any significant associations between ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA or BAG6 genes and CBZ dose or dose adjusted concentration in CBZ-tolerant patients."
24861996
SCN1A affects ERVK-10
| 1
SCN1A inhibits ERVK-10. 1 / 1
| 1
reach
"We and others have shown that mutations in Scn8a reduce spike firing in cortical excitatory and inhibitory neurons, whereas in the thalamus, the related VGSC gene Scn1a has been shown to reduce burst and tonic firing of RT cells."
28238546
SCN1A affects EPHX1
| 1
SCN1A binds EPHX1. 1 / 1
| 1
reach
"We did not observe any significant associations between ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA or BAG6 genes and CBZ dose or dose adjusted concentration in CBZ-tolerant patients."
24861996
SCN1A affects EAF2
| 1
SCN1A activates EAF2. 1 / 1
| 1
reach
"Dravet syndrome is a devastating infantile-onset epilepsy syndrome with cognitive deficits and autistic traits caused by genetic alterations in SCN1A gene encoding the alpha-subunit of the voltage gated sodium channel Na v 1.1."
23639079
SCN1A affects Dravet
| 1
SCN1A inhibits Dravet. 1 / 1
| 1
reach
"The enrichment of inhibitory neuronal expression among ASD candidate genes provides molecular support for the finding that deficits in inhibitory neuronal function occurs in some syndromes with autism associated behaviors, such as individuals with ARX mutations XREF_BIBR, XREF_BIBR, Dravet syndrome caused by loss-of-function mutations in SCN1A 72, and Tuberous Sclerosis caused by mutations in TSC1/2 XREF_BIBR, XREF_BIBR (for review, see ref."
29317598
SCN1A affects DNA Damage
| 1
SCN1A inhibits DNA Damage. 1 / 1
| 1
reach
"Except 1 mm DHA, the antioxidants reduced ROS at 4 h. Moreover, NAC 1 mm, rutin and TEMPOL reduced ROS and DNA damage in the presence of oxidative stress."
22372742
SCN1A affects DDX53
| 1
SCN1A inhibits DDX53. 1 / 1
| 1
reach
"We found that while heterozygous Scn1a mice had lowered spontaneous motor activity in home cage, they were hyperactive in novel environments."
22986304
SCN1A affects CoREST1-AAA
| 1
SCN1A binds CoREST1-AAA. 1 / 1
| 1
reach
"ChIP studies revealed reduced binding of CoREST1-AAA to the SCN1A and SCN3A promoters, although the SCN2A2 promoter was fully bound (XREF_FIG)."
19394292
SCN1A affects CYP3A4
| 1
SCN1A binds CYP3A4. 1 / 1
| 1
reach
"We did not observe any significant associations between ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA or BAG6 genes and CBZ dose or dose adjusted concentration in CBZ-tolerant patients."
24861996
SCN1A affects CTNNBL1
| 1
SCN1A binds CTNNBL1. 1 / 1
| 1
sparser
"Increased I NaP is associated with mutations in SCN1A that have been identified from individuals with epilepsy ( xref ) and is specifically reduced by AEDs such as phenytoin, valproate and lamotrigine ( xref )."
28067623
SCN1A affects CKbetaBP2
| 1
SCN1A decreases the amount of CKbetaBP2. 1 / 1
| 1
reach
"For example, NAC-1, a BTB/POZ protein, repressed transcription of the CKbetaBP2 and CRIF1 gene."
24103312
SCN1A affects CALM
| 1
SCN1A inhibits CALM. 1 / 1
| 1
reach
"Both FHM3 and autism alleles of SCN1A perturb calmodulin interacting intracellular regions of the channel protein."
24204377
SCN1A affects BCL6
| 1
BCL6 binds SCN1A. 1 / 1
| 1
sparser
"Tissue lysates from different regions of rat brain resulted in the presence and association of endogenous NAC1 and BCL6 proteins, but not the PLZF protein."
19121354
SCN1A affects Ala-Val
| 1
SCN1A inhibits Ala-Val. 1 / 1
| 1
reach
"Scn1a +/- mice have increased cardiac I Na, similar to Scn1b null mice, and display bradycardia, focal discharges, R-R variability, and bundle branch block but not AV block on ECGs obtained by telemetry of conscious animals."
25668026
SCN1A affects Action potential
1 |
SCN1A activates Action potential. 1 / 1
1 |
signor
"The expression of voltage-gated sodium channels (NaVs) is a key feature for initiation and conduction of action potentials in excitable tissues and cells such as cardiac and skeletal muscle and neurons."
26043074
SCN1A affects ARAC4
| 1
SCN1A activates ARAC4. 1 / 1
| 1
reach
"We further showed that PAT4 and SCN1, a ROP regulator, additively mediate the stability and targeting of ROP2."
28107768
SCN1A affects ACE2
| 1
SCN1A binds ACE2. 1 / 1
| 1
sparser
"Two genes, SCN1A and ACE2 , were associated with the clinical measure of non-painful orofacial symptoms, one of the predictors of TMD incidence."
24275226
SCN1A affects 3A
| 1
SCN1A binds 3A. 1 / 1
| 1
sparser
"This is due to the fact that some of these entities refer to the family of genes (for example VOLTAGE-GATED POTASSIUM CHANNEL, SCN, CYP), some entities are recognized partly (for example, SCN1 which is a part of SCN1-3A) and others are the synonyms of genes and proteins that are used as abbreviations for other biological entities in the abstracts."
19099596
SCN1A affects (5'-CCCATGATATTTGTAAGTGCAG-3'
| 1
SCN1A inhibits (5'-CCCATGATATTTGTAAGTGCAG-3'. 1 / 1
| 1
reach
"The SCN1A IVS5-91G> A polymorphism was detected directly by automated DNA sequencing post PCR amplification using forward (5 '-TTTCAGAGTCTTGAGAGCTTTG-3 ') and reverse (5 '-CCCATGATATTTGTAAGTGCAG-3 ') primers.Statistical analysis was performed using the SPSS software (version 16.0; SPSS Inc., IL, USA)."
24125961
S2 affects SCN1A
| 1
S2 inhibits mutated SCN1A. 1 / 1
| 1
reach
"Sigma 2 -antagonism (by SM 21) did not decrease epileptiform locomotor or brain activity in scn1a mutant larvae but lowered the locomotor activity of WT larvae."
28428755
RNA-Seq affects SCN1A
| 1
RNA-Seq inhibits mutated SCN1A. 1 / 1
| 1
reach
"RNA-Seq revealed three genes with significant differences in total gene expression between Scn1A deletion on the two backgrounds, including the alpha2 subunit of GABA A Rs, associating low Gabra2 expression with the B6 allele and reduced survival of Scn1A mutants on this background."
29740280
PbeDREB2A affects SCN1A
| 1
SCN1A binds PbeDREB2A. 1 / 1
| 1
reach
"Both the Y2H and BiFC assays indicated that PbeNAC1 could interact with PbeDREB1 or PbeDREB2A."
28713394
PbeDREB1 affects SCN1A
| 1
SCN1A binds PbeDREB1. 1 / 1
| 1
reach
"Both the Y2H and BiFC assays indicated that PbeNAC1 could interact with PbeDREB1 or PbeDREB2A."
28713394
PSEN1 affects SCN1A
1 |
SCN1A binds PSEN1. 1 / 1
1 |
biogrid
No evidence text available
21163940
PPARA affects SCN1A
| 1
PPARA inhibits SCN1A. 1 / 1
| 1
reach
"This effect was specific as lentiviral knockdown of PPARalpha did not modulate the short-term memory related molecule Scn1a in vivo in the hippocampus (XREF_FIG)."
23972989
PLURIPETALA affects SCN1A
| 1
PLURIPETALA activates SCN1A. 1 / 1
| 1
reach
"PLURIPETALA mediates ROP2 localization and stability in parallel to SCN1 but synergistically with TIP1 in root hairs."
27037800
PD149163 affects SCN1A
| 1
PD149163 activates SCN1A. 1 / 1
| 1
reach
"As previously found, 0.5 mg/kg of PD149163 increased pGSK-3alpha Ser21 and pGSK-3beta Ser9 in the NAc 1 h after administration."
26909848
PCDH7 affects SCN1A
| 1
SCN1A binds PCDH7. 1 / 1
| 1
sparser
"One recently published study based on 8696 cases and 26,157 controls [ xref ] identified that SCN1A and PCDH7 are associated with epilepsy."
26690205
NEUROD1 affects SCN1A
| 1
NEUROD1 increases the amount of SCN1A. 1 / 1
| 1
reach
"Beta2 (and beta4) intracellular domains can translocate into the nucleus and enhance SCN1A expression, thus functioning as transcriptional regulators of the VGSC alpha-subunit."
22798951
NANOG affects PRMT1, RNF2, SCN1A, SMARCAD1, and ZFP42
| 1
RNF2 binds SCN1A, SMARCAD1, NANOG, ZFP42, and PRMT1. 1 / 1
| 1
sparser
"The strong impact change of all three genes upon nanog downregulation is rather puzzling, as smarcad1, prmt1 and rnf2 only interact with nanog through mediators rex1 and nac1 (whose values do not change throughout the experiment) and are situated at the periphery of the ESC network [ xref ]."
22439608
NAC affects SCN1A
| 1
NAC inhibits SCN1A. 1 / 1
| 1
reach
"Representative blot in XREF_FIG and corresponding bar diagram (XREF_FIG) demonstrated that pretreatment of NAC (1 and 5 mM) to SsnB treated cells inhibited the activation on caspase-3 and brings to control levels in both SH-SY5Y (upper panel) and SK-N-BE (2) cells (middle panel) (#p < 0.05, SsnB 10 microM vs SsnB 10 microM + NAC 1 or 5 mM)."
24788776
MICA affects SCN1A
| 1
SCN1A binds MICA. 1 / 1
| 1
reach
"We did not observe any significant associations between ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA or BAG6 genes and CBZ dose or dose adjusted concentration in CBZ-tolerant patients."
24861996
MDH2 affects SCN1A
| 1
SCN1A binds MDH2. 1 / 1
| 1
sparser
"In addition, we showed that the H 2 O 2 levels increased in the hippocampus of the seizure mice, and H 2 O 2 could promote the binding of MDH2 to the binding sites of Scn1a gene, whereas Ī²-mercaptoethanol decreased the binding capability, indicating an important effect of the seizure-induced oxidation on the MDH2-mediated downregulation of Scn1a expression."
28433711
LFP affects SCN1A
| 1
LFP activates SCN1A. 1 / 1
| 1
reach
"However, similar to the anesthetized condition, no significant differences were detected in the LFP signal in Scn1a -/+ mice compared with controls."
26819275
KDM5B affects SCN1A
| 1
KDM5B inhibits SCN1A. 1 / 1
| 1
reach
"We found that knockdown of KDM5B inhibited TPA mediated repression of SCN1A and ITPR1 (XREF_FIG)."
20832725
KCN affects SCN1A, and Voltage_gated_ion_channels
| 1
KCN binds Voltage_gated_ion_channels and SCN1A. 1 / 1
| 1
sparser
"For example, Dravet syndrome is a devastating epileptic encephalopathy that associates with mutations in the human SCN1A gene encoding the voltage gated potassium channel subunit Na v 1.1."
29506031
Intravenous injections AAV particles containing gRNAs mice Scn1a-haplodeficiency neuron-specific dCas9-VPR affects SCN1A
| 1
Intravenous injections AAV particles containing gRNAs mice Scn1a-haplodeficiency neuron-specific dCas9-VPR inhibits SCN1A. 1 / 1
| 1
eidos
"Intravenous injections of AAV particles containing the optimal combination of 4 gRNAs into transgenic mice with Scn1a-haplodeficiency and inhibitory neuron-specific expression of dCas9-VPR at four weeks of age increased Nav1.1 expression in parvalbumin-positive GABAergic neurons , ameliorated their febrile seizures and improved their behavioral impairments ."
32445790
IL10 affects SCN1A
1 |
Transcriptionally active IL10 decreases the amount of SCN1A. 1 / 1
1 |
signor
"Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-Ī±."
23357618
Hm1a affects SCN1A
| 1
Hm1a activates SCN1A. 1 / 1
| 1
reach
"7 The Petrou group showed that application of Hm1a to mouse brain slices rescued hippocampal CA1 PV+ fast spiking interneuron function in Scn1a +/- DS mice but, surprisingly, had no effect on CA1 inhibitory neuron firing in WT littermate mice or on excitatory CA1 pyramidal neurons in DS mice."
30838929
Histone_H3 affects SCN1A
| 1
Histone_H3 acetylates SCN1A. 1 / 1
| 1
reach
"We found that de-conjugation of SUMO-2/3 led to de-repression, loss of promoter occupancy by CoREST1 and LSD1, increased H3K4 methylation, and increased H3 acetylation of the SCN1A and SCN3A genes, but did not affect another CoREST1 and LSD1 target gene, SCN2A2."
19394292
HRH1 affects SCN1A
| 1
SCN1A binds HRH1. 1 / 1
| 1
sparser
"It is interesting to note that NAB2, a GWAS gene, is predicted to interact with two of these novel genes HRH1 and SCN1A that are targeted by nervous system drugs."
27336055
Glu-Glu-Gly affects SCN1A
| 1
Glu-Glu-Gly activates mutated SCN1A. 1 / 1
| 1
reach
"High-frequency EEG oscillations in hyperthermia induced seizures of Scn1a mutant rats."
22920678
GAPDH affects SCN1A
| 1
GAPDH activates SCN1A. 1 / 1
| 1
reach
"GAPDH mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions."
27816501
GAN affects SCN1A
1 |
SCN1A binds GAN. 1 / 1
1 |
biogrid
No evidence text available
26460568
FST affects GABRG2, and SCN1A
| 1
SCN1A binds FST and GABRG2. 1 / 1
| 1
sparser
"Among all the epilepsy genes, mutations in SCN1A and GABRG2 have been strongly associated with FS and extended epilepsy syndromes like generalized epilepsy with febrile plus (GEFS+) and Dravet syndrome xref ā€“ xref ."
28505490
FAS affects SCN1A
| 1
SCN1A binds FAS. 1 / 1
| 1
reach
"We did not observe any significant associations between ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA or BAG6 genes and CBZ dose or dose adjusted concentration in CBZ-tolerant patients."
24861996
ESR2 affects SCN1A
1 |
Transcriptionally active ESR2 decreases the amount of SCN1A. 1 / 1
1 |
signor
"17Ī²-Estradiol regulates the gene expression of voltage-gated sodium channels. . In this study, we investigate the mRNA expressions of Nav channel subtypes mediated differentially by the ERs in the DRGs of wild-type (WT) and estrogen receptor knockout (Ī±ERKO and Ī²ERKO) mice. In the present study, by means of quantitative real-time PCR, we found that the expressions of Nav1.1, Nav1.7, Nav1.8, and Nav1.9 subtypes were elevated in Ī±ERKO and Ī²ERKO mice"
22169964
ESR1 affects SCN1A
1 |
Transcriptionally active ESR1 decreases the amount of SCN1A. 1 / 1
1 |
signor
"17Ī²-Estradiol regulates the gene expression of voltage-gated sodium channels. . In this study, we investigate the mRNA expressions of Nav channel subtypes mediated differentially by the ERs in the DRGs of wild-type (WT) and estrogen receptor knockout (Ī±ERKO and Ī²ERKO) mice. In the present study, by means of quantitative real-time PCR, we found that the expressions of Nav1.1, Nav1.7, Nav1.8, and Nav1.9 subtypes were elevated in Ī±ERKO and Ī²ERKO mice"
22169964
EPHX1 affects SCN1A
| 1
SCN1A binds EPHX1. 1 / 1
| 1
reach
"We did not observe any significant associations between ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA or BAG6 genes and CBZ dose or dose adjusted concentration in CBZ-tolerant patients."
24861996
CoREST1-AAA affects SCN1A
| 1
SCN1A binds CoREST1-AAA. 1 / 1
| 1
reach
"ChIP studies revealed reduced binding of CoREST1-AAA to the SCN1A and SCN3A promoters, although the SCN2A2 promoter was fully bound (XREF_FIG)."
19394292
CoREST1 affects SCN1A
| 1
CoREST1 inhibits SCN1A. 1 / 1
| 1
reach
"These data indicate that stable binding of CoREST1 and transcriptional repression of the SCN1A and SCCN3A genes are dependent on an intact CoREST1 SIM."
19394292
CYP3A4 affects SCN1A
| 1
SCN1A binds CYP3A4. 1 / 1
| 1
reach
"We did not observe any significant associations between ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA or BAG6 genes and CBZ dose or dose adjusted concentration in CBZ-tolerant patients."
24861996
CTNNBL1 affects SCN1A
| 1
SCN1A binds CTNNBL1. 1 / 1
| 1
sparser
"Increased I NaP is associated with mutations in SCN1A that have been identified from individuals with epilepsy ( xref ) and is specifically reduced by AEDs such as phenytoin, valproate and lamotrigine ( xref )."
28067623
CRM197 affects SCN1A
| 1
CRM197 activates SCN1A. 1 / 1
| 1
reach
"CRM197 reverses paclitaxel resistance by inhibiting the NAC-1 and Gadd45 pathway in paclitaxel resistant ovarian cancer cells."
31490008
CNTNAP2 affects DEPDC5, EAF family, and SCN1A
| 1
SCN1A binds CNTNAP2, DEPDC5, and EAF family. 1 / 1
| 1
sparser
"The association of EAF with CNTNAP2 , DEPDC5 , and SCN1A mutations widens the phenotypic spectrum related to these genes."
27066544
CB2Rs affects SCN1A
| 1
CB2Rs inhibits SCN1A. 1 / 1
| 1
reach
"We also examined seizure susceptibility in Cnr2 mutants harboring the human SCN1A R1648H (RH) epilepsy mutation and performed Electroencephalography (EEG) analysis to determine whether the loss of CB2Rs would increase spontaneous seizure frequency in Scn1a RH mutant mice."
31758544
CARM1 affects SCN1A
| 1
CARM1 methylates SCN1A. 1 / 1
| 1
reach
"The analysis clearly showed that CARM1 methylates histone H3, but not GST or GST-NAC1."
29983869
BCL6 affects SCN1A
| 1
BCL6 binds SCN1A. 1 / 1
| 1
sparser
"Tissue lysates from different regions of rat brain resulted in the presence and association of endogenous NAC1 and BCL6 proteins, but not the PLZF protein."
19121354
AntagoNATs affects SCN1A
| 1
AntagoNATs activates SCN1A. 1 / 1
| 1
reach
"3.10 Intrathecal Injection of Human AntagoNATs Upregulates Scn1a in Non human Primate Brain."
27333023
Alzheimer Disease affects SCN1A
| 1
Alzheimer Disease inhibits SCN1A. 1 / 1
| 1
reach
"Immunoblotting showed that captopril had prevented the AD related down-regulation of hippocampal Scn1a, i.e., the sodium channel, voltage gated, type I, alpha (XREF_FIG)."
23959119
ARX affects SCN1A, and SCN1B
| 1
SCN1A binds SCN1B and ARX. 1 / 1
| 1
sparser
"Investigation of genes associated with infantile forms of epilepsy such as SCN1A, SCN1B, and ARX were negative, but we identified a novel single-nucleotide duplication mutation, c."
22596016
ARX affects CDKL5, KCNQ2, MECP2, SCN1A, and STXBP1
| 1
SCN1A binds CDKL5, STXBP1, KCNQ2, MECP2, and ARX. 1 / 1
| 1
sparser
"Genes associated with early-onset epilepsy, STXBP1 , KCNQ2 , CDKL5 , SCN1A , MECP2 and ARX, and several genes associated with neurometabolic disease including POLG1 and NDUFAF1 were sequenced with no significant variations ."
23550958
ARSD affects SCN1A, SCN2A, SCN3A, SCN7A, and SCN8A
| 1
SCN1A binds SCN2A, SCN3A, SCN7A, SCN8A, and ARSD. 1 / 1
| 1
sparser
"SCN1A , SCN2A , SCN3A , SCN7A and SCN8A are associated with ASD [ xref ]."
25592685
ARSD affects SCN1A
| 1
ARSD inhibits SCN1A. 1 / 1
| 1
reach
"Utilizing the reciprocal interaction protocol, decreased interactions have been observed in Scn1a +/-, BTBR T+ tf/J, and C58J mouse models of ASD."
28463420
APP affects SCN1A
1 |
Transcriptionally active APP increases the amount of SCN1A. 1 / 1
1 |
biopax:ctd
No evidence text available
21298039
ADRB2 affects SCN1A
| 1
ADRB2 inhibits mutated SCN1A. 1 / 1
| 1
reach
"A selective antagonist of the beta 2 -adrenergic receptor (ICI 118551) was able to significantly reduce the locomotor activity of scn1a mutant larvae."
28428755
ACTA1 affects COL10A1, and SCN1A
| 1
SCN1A binds ACTA1 and COL10A1. 1 / 1
| 1
sparser
"Mutations in SCN1A gene encoding the alpha 1 subunit of the voltage gated sodium channel are associated with several epilepsy syndromes including genetic epilepsy with febrile seizures plus (GEFSĀ +) and severe myoclonic epilepsy of infancy (SMEI)."
28664031
ACE2 affects SCN1A
| 1
SCN1A binds ACE2. 1 / 1
| 1
sparser
"Two genes, SCN1A and ACE2 , were associated with the clinical measure of non-painful orofacial symptoms, one of the predictors of TMD incidence."
24275226
ABCB1 affects GABRG2, and SCN1A
| 1
SCN1A binds ABCB1 and GABRG2. 1 / 1
| 1
sparser
"Functionally significant association of drug target genes such as GABRG2 and SCN1A and efflux transporter gene ABCB1 to susceptibility to epilepsy in the present population needs to be seen in combination rather than isolation in evaluating therapeutic response."
24586633
ABCB1 affects CYP2C19, CYP2C9, SCN1A, and UGT2B7
| 1
SCN1A binds UGT2B7, CYP2C19, CYP2C9, and ABCB1. 1 / 1
| 1
sparser
"The primary goals of this study were the following: (i) to analyze the association between several single nucleotide polymorphisms (SNPs) of the CYP2C9, CYP2C19, UGT2B7, ABCB1, and SCN1A genes by bivariate analysis and (ii) to analyze these associations taking into account some factors related with the patient and his/her epilepsy by multivariate analysis."
20064729
AAV9-NaVbeta1 affects SCN1A
| 1
AAV9-NaVbeta1 activates SCN1A. 1 / 1
| 1
reach
"In the AAV treated mice, there was no difference in the chamber temperature required to induce seizures in male (XREF_FIG) versus female (XREF_FIG) Scn1a +/- mice injected with AAV-EV compared with those treated with AAV9-NaVbeta1."
31830809
AAA affects SCN1A
| 1
Mutated AAA decreases the amount of SCN1A. 1 / 1
| 1
reach
"CoREST1-AAA-res also restored repression of SCN2A2, but the CoREST1 AAA mutant failed to repress transcription of SCN1A or SCN3A (XREF_FIG)."
19394292
3A affects SCN1A
| 1
SCN1A binds 3A. 1 / 1
| 1
sparser
"This is due to the fact that some of these entities refer to the family of genes (for example VOLTAGE-GATED POTASSIUM CHANNEL, SCN, CYP), some entities are recognized partly (for example, SCN1 which is a part of SCN1-3A) and others are the synonyms of genes and proteins that are used as abbreviations for other biological entities in the abstracts."
19099596
3-hydroxybutyric acid affects SCN1A
| 1
3-hydroxybutyric acid increases the amount of SCN1A. 1 / 1
| 1
reach
"Furthermore, administration of KD generates beta-hydroxybutyric acid which rescues the abnormal expressions of Scn1a and Scn3a by weakening the GAPDH 's binding to the element."
27816501