INDRA statements for SCN11A

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
SCN11A affects activity
| 11
SCN11A inhibits activity. 11 / 11
| 11
sparser
"Furthermore, in MRF in neutrophils in the presence of NaN3, which inhibits the enzymatic activity of bath catalase and MPO, can serve as an argument against the involvement of rnyeloperoxidase in the intracellular oxidation of DHR."
8666838
sparser
"In this study, TLCAT activity was strongly inhibited by NaN 3 and KCN which indicates that TLCAT is a heme-containing catalase."
29124232
sparser
"Inhibition of SOD activity of leishmanial supernatants by NaN3."
7306201
sparser
"Tg-Hb peroxidase activity was also inhibited by NaN 3 in a dose-dependent manner ( xref )."
28182094
sparser
"The inhibition of the Ss SOD activity by NaCN (1–2 mM) or NaN 3 (5–10 mM) was tested by the separate addition of the two compounds in the standard assay."
9428655
sparser
"The activity of LacE was strongly inhibited by NaN(3) but not by EDTA or dimethylsulfoxide."
17122892
sparser
"Laccase A activity is strongly inhibited by 0.1 mM NaN(3) or 0.1 mM cyanide."
12664149
sparser
"In addition, Tg-Hbs showed maximal peroxidase activity at pH 5.0 and the activity was inhibited by NaN 3 ."
28182094
sparser
"The enzymic activity is inhibited by NaN3, NaF, adenosine 5'-[beta,gamma-imido]triphosphate and adenosine 5'-[alpha,beta-methylene]triphosphate."
8529670
sparser
"The presence of EDTA, β-mercaptoethanol, and respiratory inhibitor NaN 3 significantly inhibited the extracellular chromate reductase activity of SUK 1201 and the % relative activity was found to be 23.87, 6.47, and 34.47%, respectively ( Table 1 )."
27176938
sparser
"Inhibition (MM) (%) NaN3 1.0 6o 0.1 45 KCN 1.0 72 0.1 40 NH20H 1.0 50 CO (gassed for 2 min) o Inhibitors of nitrite yeductase The nitrite reductase activity was strongly inhibited by NaN3, and KCN at i mM when PMS plus NADH was the donor."
4309366
SCN11A affects KLF1
| 11
SCN11A binds KLF1.
| 10
SCN11A binds KLF1. 10 / 10
| 10
sparser
"We propose a model whereby ectopic binding of Nan-KLF1 not only directly drives aberrant gene transcription, but sometimes indirectly disrupts the activity of KLF1-independent erythroid genes or housekeeping genes."
28180284
sparser
"ChIPseq confirmed ectopic Nan-KLF1 binding to an altered consensus sequence, CCM- NG C-CCN, with the result that >60% of Nan-KLF1 occupied sites do not overlap wild type (WT) KLF1 sites."
30143664
sparser
"Despite this, expression of genes that mutant Nan-KLF1 does not bind is somehow disrupted through an unknown mechanism."
30143664
sparser
"Exploring the relationship between aberrant Nan-KLF1 binding and ectopic gene regulation at the genome-wide level we find 205 KLF1 promoter peaks within KLF1 DEGs (28%) and 102 Nan-KLF1 promoter peaks within the Nan-KLF1 DEGs (9%)."
28180284
sparser
"Whereas KLF1 only binds G, Nan-KLF1 binds A, G or T at this position in vitro and in vivo ."
28180284
sparser
"Indeed, we previously reported reduced Nan-KLF1 binding to some established KLF1 target sites in vitro by EMSA ( xref )."
28180284
sparser
"Ectopic transcription is activated following ectopic Nan-KLF1 binding to DNA."
28180284
sparser
"We found no evidence for Nan-KLF1 binding."
28180284
sparser
"Nan-KLF1 binds an altered sequence motif."
28180284
sparser
"Nan-KLF1 also ectopically binds sites not normally engaged by KLF1 xref , xref ."
30143664
SCN11A activates KLF1.
| 1
SCN11A activates KLF1. 1 / 1
| 1
sparser
"For example, some known KLF1 target genes, such as Alas2 ( xref ) and Klf10 ( xref ), are activated equally (4.4-fold and ∼100-fold up-regulated respectively) by KLF1 and Nan-KLF1, while other KLF1 target genes such as Alad ( xref ) and Hbb-b1 ( xref ) are more responsive to KLF1."
28180284
KLF1 affects SCN11A
| 10
SCN11A binds KLF1. 10 / 10
| 10
sparser
"We propose a model whereby ectopic binding of Nan-KLF1 not only directly drives aberrant gene transcription, but sometimes indirectly disrupts the activity of KLF1-independent erythroid genes or housekeeping genes."
28180284
sparser
"ChIPseq confirmed ectopic Nan-KLF1 binding to an altered consensus sequence, CCM- NG C-CCN, with the result that >60% of Nan-KLF1 occupied sites do not overlap wild type (WT) KLF1 sites."
30143664
sparser
"Despite this, expression of genes that mutant Nan-KLF1 does not bind is somehow disrupted through an unknown mechanism."
30143664
sparser
"Exploring the relationship between aberrant Nan-KLF1 binding and ectopic gene regulation at the genome-wide level we find 205 KLF1 promoter peaks within KLF1 DEGs (28%) and 102 Nan-KLF1 promoter peaks within the Nan-KLF1 DEGs (9%)."
28180284
sparser
"Whereas KLF1 only binds G, Nan-KLF1 binds A, G or T at this position in vitro and in vivo ."
28180284
sparser
"Indeed, we previously reported reduced Nan-KLF1 binding to some established KLF1 target sites in vitro by EMSA ( xref )."
28180284
sparser
"Ectopic transcription is activated following ectopic Nan-KLF1 binding to DNA."
28180284
sparser
"We found no evidence for Nan-KLF1 binding."
28180284
sparser
"Nan-KLF1 binds an altered sequence motif."
28180284
sparser
"Nan-KLF1 also ectopically binds sites not normally engaged by KLF1 xref , xref ."
30143664
SCN11A affects HRP
| 5
SCN11A inhibits HRP. 5 / 5
| 5
sparser
"Sequential reprobing of membranes with a variety of antibodies was performed after the complete removal of primary and secondary antibodies from membranes in stripping buffer or inactivation of HRP by 0.1% NaN 3 , according to the manufacturer's instructions."
18817770
sparser
"Sequential reprobing of membranes with a variety of antibodies was performed after the complete removal of primary antibodies from membranes in stripping buffer or inactivation of HRP by 0.1% NaN, according to the manufacturer's instructions."
22001646
sparser
"Sequential reprobing of membranes with a variety of antibodies was performed after the complete removal of primary and secondary antibodies from the membranes in stripping buffer or inactivation of HRP by 0.1% NaN 3 according to the manufacturer’s instructions."
23562843
sparser
"Sequential reprobing of membranes with a variety of antibodies was performed after inactivation of HRP by 0.1% NaN, according to the manufacturer’s instructions."
24041959
sparser
"Sequential reprobing of membranes with a variety of antibodies was performed after the complete removal of primary and secondary antibodies from membranes in stripping buffer or inactivation of HRP by 0.1% NaN 3 , according to the manufacture's instructions."
17537435
Mor affects SCN11A
| 4
SCN11A binds amdR and mor. 2 / 2
| 2
sparser
"As INTA has a β -configuration linker while NAN has an α one, this led to opposite conformations of the cyclohexyl ring in the skeletons in order to accommodate the “address” portion of the molecules when the “message” portions of NAN and INTA bound to the orthosteric binding site of the MOR."
30156823
sparser
"Molecular modeling studies revealed that INTA and NAN may interact with different domains of the MOR allosteric binding site."
30156823
SCN11A binds mor. 1 / 1
| 1
sparser
"However, the K i value for NAN binding to MOR we previously reported ( K i (nM) = 0.23 ± 0.02) xref was lower than the K e values obtained here."
30758946
SCN11A binds TP53INP2, mor, and KOR. 1 / 1
| 1
sparser
"The binding modes of the NAN_MOR, NAN_KOR, and NAN_DOR complexes after 10 ns MD simulations are shown in xref , where it can be seen that NAN bound to the same binding domain of the MOR, KOR, and DOR."
30758946
SCN11A affects hydrogen chloride
| 3
SCN11A inhibits hydrogen chloride. 3 / 3
| 3
sparser
"24 h PEC: Whereas luminol-amplified CL (EC50 < 10-6 mol/1) was strongly inhibited by NAN3, lucigenin-amplified CL (EC50 > 10 3mol/1) was enhanced in a concentration-related manner."
6094369
sparser
"Because the CL was inhibited by NaN 3 , a quencher of 1 O 2 , and was not completely inhibited by SOD, 1 O 2 was considered to be produced in the sonodynamic action."
12048159
sparser
"However, the CL was inhibited markedly (about 71.5%) by NaN 3 , which is an effective quencher of 1 O 2 ."
12406549
SCN11A affects formation
| 3
SCN11A inhibits formation. 3 / 3
| 3
sparser
"Furthermore, NaN inhibited 8-OHdG formation induced by BPDE and UVA in a concentration-dependent manner (C)."
16214033
sparser
"Patch formation was also inhibited by NaN3, though some cells still displayed widely separated spots."
4577516
sparser
"Lipid peroxide formation was inhibited by NaN 3 (singlet oxygen and free radical scavenger) and was enhanced by the presence of deuterium oxide (D 2 O) (extends singlet oxygen lifetime)."
17617679
SCN11A affects CPOX
| 3
SCN11A inhibits CPOX. 3 / 3
| 3
sparser
"The tissue-specific inhibition of COX by NaN 3 may serve as a useful tool for the evaluation of AD in vivo and in vitro ."
29115393
sparser
"The tissue-specific inhibition of COX by NaN 3 could serve as a useful research tool for the evaluation of cell death in vivo and in vitro ."
28849152
sparser
"The model of brain mitochondrial COX inhibition by NaN 3 was described in rats in an attempt to mimic the morphological and behavioral pathology of AD ( xref )."
29115393
HpTx1 affects SCN11A
| 3
HpTx1 activates SCN11A. 3 / 3
| 3
eidos
"HpTx1 inhibits Nav1.7 and activates Nav1.9 but does not affect Nav1.8 ."
32385249
eidos
"HpTx1 evoked robust pain responses and produced profound hypersensitivity to mechanical and thermal stimuli in Nav1.7-KO mice ( Fig.1c-e ) , as revealed by the depolarized RMP , reduced rheobase and increased AP firing in some small DRG neurons with Nav1.9 activation by HpTx1 ( Fig.2e-g ) ."
32385249
eidos
"Taken together , these results suggested that HpTx1 enhances Nav1.9 activity by inhibiting its fast inactivation and that the mechanism by which HpTx1 improves membrane excitability and evokes pain in Nav1.7-KO mice might be related to this enhanced Nav1.9 activity ."
32385249
TNF affects SCN11A
2 |
TNF increases the amount of SCN11A.
1 |
Transcriptionally active TNF increases the amount of SCN11A. 1 / 1
1 |
signor
"TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels."
26112872
TNF activates SCN11A.
1 |
TNF activates SCN11A. 1 / 1
1 |
signor
"TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels."
26112872
SCN11A affects transcription, DNA-templated
| 1 1
SCN11A inhibits transcription, DNA-templated. 2 / 2
| 1 1
sparser
"Hypoxia-induced RBM3 or CIRP transcription was inhibited by the respiratory chain inhibitors NaN(3) and cyanide in a dose-dependent fashion."
15075239
reach
"Inhibition of HATs by anacardic acid caused a reduction in transcription by the PN5 stage, while treatment with TSA was without effect (XREF_FIG)."
28878090
SCN11A affects sodium(1+)
1 | 1
SCN11A increases the amount of sodium(1+).
1 |
SCN11A increases the amount of sodium(1+). 1 / 1
1 |
signor
"Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential."
27262167
SCN11A activates sodium(1+).
| 1
SCN11A activates sodium(1+). 1 / 1
| 1
reach
"Congenital insensitivity to pain : Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage gated sodium channel 1.9."
26746779
SCN11A affects reaction
| 2
SCN11A inhibits reaction. 2 / 2
| 2
sparser
"The reaction was inhibited by NaN3, a selective quencher of singlet oxygen."
9301026
sparser
"Since the reaction was not inhibited by 0.1 millimolar NaN(3) and did not occur in the dark, it was concluded that catalase was not involved."
16662413
SCN11A affects peroxidase family
| 2
SCN11A inhibits peroxidase family. 2 / 2
| 2
sparser
"It is established that NaN 3 inhibits peroxidases by modification to the heme ring through formation of a δ-meso-azidoheme adduct rather than direct interaction of the azide with the chelated Fe molecule [ xref ]."
24632143
sparser
"The NaN 3 could strongly inhibit this peroxidase."
23402438
SCN11A affects oxidation
| 2
SCN11A inhibits oxidation. 2 / 2
| 2
sparser
"The NaN 3 can inhibit nitrite oxidation effectively; meanwhile, the nitrite denitrification with N 2 O as the final products was largely improved."
28278783
sparser
"Hb-induced LDL oxidation was inhibited by NaN(3) and catalase."
21034361
SCN11A affects hydrolysis
| 2
SCN11A inhibits hydrolysis. 2 / 2
| 2
sparser
"The hydrolysis of ATP was inhibited by 5 mM NaN3, suramin, ATPgammaS, La3+ and CTP, the hydrolysis of ADP by beta,gamma-imidoATP, and AMP degradation by alpha,beta-methyleneADP."
9580435
sparser
"Under identical assay conditions, the granule ATPase was insensitive to concentrations of NaN3, oligomycin, and efrapeptin which almost completely inhibit ATP hydrolysis by mitochondrial membranes."
6204985
SCN11A affects hpf
| 2
SCN11A activates hpf. 2 / 2
| 2
sparser
"The explanation for the potentiation of HPF activation by NaN 3 may be that azide radicals (N3•) can be formed from HO • and azide anion ( xref )."
22760848
sparser
"Because of the somewhat surprising observation that NaN 3 potentiated activation of HPF (and to a lesser extent activation of SOSG) by BB6 and light, we asked whether NaN 3 could also potentiate the activation of HPF by HO • generated by Fenton reagent. xref shows a high degree of potentiation of fluorescence generation by NaN 3 while DMT gave almost complete quenching (as might be expected from its ability to quench HO • )."
22760848
SCN11A affects enzyme activity
| 2
SCN11A inhibits enzyme activity. 2 / 2
| 2
sparser
"As shown in Table 3 , p -chloromercuribenzoate, HgCl 2 and NaN 3 completely inhibited the enzyme activity."
12204385
sparser
"The enzyme activity was strongly inhibited by NaN(3), p-chloromercuribenzoate and HgCl(2)."
12204385
SCN11A affects amdR, and mor
| 2
SCN11A binds amdR and mor. 2 / 2
| 2
sparser
"As INTA has a β -configuration linker while NAN has an α one, this led to opposite conformations of the cyclohexyl ring in the skeletons in order to accommodate the “address” portion of the molecules when the “message” portions of NAN and INTA bound to the orthosteric binding site of the MOR."
30156823
sparser
"Molecular modeling studies revealed that INTA and NAN may interact with different domains of the MOR allosteric binding site."
30156823
SCN11A affects accumulation
| 2
SCN11A inhibits accumulation. 2 / 2
| 2
sparser
"External accumulation of GSH was inhibited by 30 mM NaN3."
3531162
sparser
"This accumulation was inhibited by apically loaded NaN(3)."
16004960
SCN11A affects PBS
| 2
SCN11A binds PBS. 2 / 2
| 2
sparser
"All reagents were diluted in PBS-NaN, and all incubations were carried out for 30 min on ice."
9220587
sparser
"Before labeling, the red blood cells in the TCF were lysed with 0.17 mM Tris-0.14 M ammonium chloride buffer (pH 7.2) and the remaining cells were incubated in PBS with 0.02% NaN, (PBS-NaN,) for 30 min at 37°C to remove cytophilic antibodies (Watson, 1976) ."
9220587
SCN11A affects NAG
| 2
SCN11A binds NAG. 2 / 2
| 2
sparser
"We found that this GI of ~64 kb is inserted in the tRNA- ser gene and located next to a nan-nag region involved in the sialic acid catabolism ( xref ), which is also harboured by the VPI-II [ xref ]."
32100707
sparser
"We found that this GI of ~64 kb is inserted in the tRNA- ser gene and located next to a nan-nag region involved in the sialic acid catabolism ( xref ), which is also harboured by the VPI-II [ xref ]."
32100707
SCN11A affects ATPase activity
| 2
SCN11A inhibits ATPase activity. 2 / 2
| 2
sparser
"Inhibition of the F o F 1 -ATPase by NaN 3 is also observed for the sodium translocating F o F 1 -ATPase from P. modestum ( Laubinger and Dimroth, 1988 )."
12944317
sparser
"The membrane-bound ATPase activity was inhibited by DCCD and NaN3."
7947906
PBS affects SCN11A
| 2
SCN11A binds PBS. 2 / 2
| 2
sparser
"All reagents were diluted in PBS-NaN, and all incubations were carried out for 30 min on ice."
9220587
sparser
"Before labeling, the red blood cells in the TCF were lysed with 0.17 mM Tris-0.14 M ammonium chloride buffer (pH 7.2) and the remaining cells were incubated in PBS with 0.02% NaN, (PBS-NaN,) for 30 min at 37°C to remove cytophilic antibodies (Watson, 1976) ."
9220587
NEDD4L affects SCN11A
2 |
NEDD4L ubiquitinates SCN11A.
1 |
NEDD4L ubiquitinates SCN11A. 1 / 1
1 |
signor
"The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2)."
23778145
NEDD4L decreases the amount of SCN11A.
1 |
NEDD4L decreases the amount of SCN11A. 1 / 1
1 |
signor
"The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2)."
23778145
NAG affects SCN11A
| 2
SCN11A binds NAG. 2 / 2
| 2
sparser
"We found that this GI of ~64 kb is inserted in the tRNA- ser gene and located next to a nan-nag region involved in the sialic acid catabolism ( xref ), which is also harboured by the VPI-II [ xref ]."
32100707
sparser
"We found that this GI of ~64 kb is inserted in the tRNA- ser gene and located next to a nan-nag region involved in the sialic acid catabolism ( xref ), which is also harboured by the VPI-II [ xref ]."
32100707
FGF14 affects SCN11A
2 |
FGF14 inhibits SCN11A.
1 |
FGF14 inhibits SCN11A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF14 binds SCN11A.
1 |
SCN11A binds FGF14. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF13 affects SCN11A
2 |
FGF13 inhibits SCN11A.
1 |
FGF13 inhibits SCN11A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF13 binds SCN11A.
1 |
SCN11A binds FGF13. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF12 affects SCN11A
2 |
FGF12 inhibits SCN11A.
1 |
FGF12 inhibits SCN11A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF12 binds SCN11A.
1 |
SCN11A binds FGF12. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF11 affects SCN11A
2 |
FGF11 inhibits SCN11A.
1 |
FGF11 inhibits SCN11A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF11 binds SCN11A.
1 |
SCN11A binds FGF11. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
Tetrodotoxin affects SCN11A
| 1
Tetrodotoxin inhibits SCN11A. 1 / 1
| 1
reach
"The voltage gated sodium channel family is comprised of ten members : SCN1A (Nav1.1), SCN2A (Nav1.2; SCN2A1 in mouse), SCN3A (Nav1.3), SCN4A (Nav1.4), SCN8A (Nav1.6), and SCN9A (Nav1.7) are blocked by tetrodotoxin, whereas SCN5A (Nav1.5), SCN7A (Nax), SCN10A (Nav1.8), and SCN11A (Nav1.9) are not blocked by tetrodotoxin [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
19284629
Tat affects SCN11A
| 1
SCN11A binds tat. 1 / 1
| 1
sparser
"Surprisingly, in the absence of Tat expression, addition of NaN 3 was associated with derepression of basal HIV promoter activity ( xref )."
22140357
Sodium atom affects SCN11A
| 1
Sodium atom activates SCN11A. 1 / 1
| 1
reach
"Na 10 SnP 2 S 12 was synthesized by mixing stoichiometric amounts of Na 2 S (Kojundo Chemical Laboratory Co. Ltd, 99%), P 2 S 5 (Sigma-Aldrich Co., 99%) and SnS 2 (Kojundo Chemical Laboratory Co. Ltd, 99.9%) with a planetary ballmill (380r."
26984102
Silver(1+) affects SCN11A
| 1
Silver(1+) activates SCN11A. 1 / 1
| 1
reach
"This study demonstrates that an optimal amount of Ag doping can effectively increase the photocatalytic performance of SnS 2 and will promote the commercialization of such photocatalysts in the photocatalytic degradation of organic compounds."
27711732
Regulating endogenous molecules affects SCN11A
| 1
Regulating endogenous molecules activates SCN11A. 1 / 1
| 1
eidos
"Therefore , enhancing the activation of Nav1.9 by regulating these endogenous molecules may be a feasible strategy for treating CIP ."
32385249
Phosphatidic acid affects SCN11A
| 1
Phosphatidic acid binds SCN11A. 1 / 1
| 1
sparser
"Similarly, using surface plasmon resonance, we were not able to detect any specific binding of Nan PA subunit to a DNA substrate using 1 μM protein (data not shown)."
22841552
Parecoxib affects SCN11A
| 1
Parecoxib inhibits SCN11A. 1 / 1
| 1
reach
"Parecoxib (an anti-inflammatory medication) relieved the heat hypersensitivity in Scn11a mice not receiving inflammatory stimuli and significantly decreased the hyperexcitability of DRG neurons in Scn11a mice."
32132394
Palladium affects SCN11A
| 1
Palladium inhibits SCN11A. 1 / 1
| 1
reach
"Taking advantage of the excellent catalytic ability and biocompatibility, palladium nanoparticles (Pd NPs) were in situ reduced on SnS 2 NFs to obtain SnS 2 -Pd."
30928738
Imatinib affects SCN11A
| 1
Imatinib activates SCN11A. 1 / 1
| 1
reach
"For in vivo analysis, PN5 CD1 mice were treated with vehicle or imatinib (7.5 mg/kg i.p.) or cisplatin, (5 mg/kg i.p.) or both imatinib and cisplatin administered together (as in Gonfloni et al 3)."
22869179
Hydrogen sulfide affects SCN11A
| 1
Hydrogen sulfide activates SCN11A. 1 / 1
| 1
reach
"Excess sulfur drives a spontaneous transformation of the few-layer SnS to SnS 2, whose orientation - rotated 30degrees against the underlying SnS 2 crystal - is defined by the SnS intermediate rather than the substrate."
31797928
Hsa-miR-30c-5p affects SCN11A
1 |
Transcriptionally active hsa-miR-30c-5p decreases the amount of SCN11A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-196a-5p affects SCN11A
1 |
Transcriptionally active hsa-miR-196a-5p decreases the amount of SCN11A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Histamine affects SCN11A
| 1
Histamine activates SCN11A. 1 / 1
| 1
eidos
"Histamine has been found to improve the activity of Nav1.9 and enhance AP firing in DRG neurons37 ,48,49 ."
32385249
ST14 affects SCN11A
| 1
SCN11A binds ST14. 1 / 1
| 1
sparser
"Healthy mandarin fish (weight ∼250 g) were obtained from a fish farm in Nan-Hai (Guangdong Province, China) and maintained for at least 2 weeks in aquaria at 28 • C. Freshly dissected tissues, including brain, fat tissue, heart, hemocytes, gills, intestines, liver, muscle, kidney, and spleen, were washed thoroughly with phosphate buffered saline (PBS) and immediately homogenized with thiourea lysis buffer (7 M urea, 2 M thiourea, 4% CHAPS) containing protease inhibitor cocktail set III (Calbiochem, USA)."
21296425
SGR affects SCN11A
| 1
SCN11A binds SGR. 1 / 1
| 1
sparser
"Transcript profiling indicated that a SGR -like ( STAY-GREEN ) gene was expressed at lower levels in nan flavedo, suggesting that nan mutation could be associated to a SGR -like upstream regulatory factor [ xref ]."
21159189
SCN11A affects transport
| 1
SCN11A activates transport. 1 / 1
| 1
reach
"Such a well designed heterogeneity between ZnS and SnS 2 provides rapid Na + insertion and enhanced charge transport by creating an electric field at the heterointerface."
30675762
SCN11A affects translocation
| 1
SCN11A inhibits translocation. 1 / 1
| 1
sparser
"Chromatin condensation and translocation of phosphatidylserine were also inhibited by NaN(3), suggesting that the induction of apoptosis by coexposure to BaP plus UVA was due to singlet oxygen production."
21782591
SCN11A affects threshold
| 1
SCN11A inhibits threshold. 1 / 1
| 1
eidos
"Our data demonstrated that the enhanced activity of Nav1.9 reduces the current threshold , showing that , similar to Nav1.7 , Nav1.9 can also function as a gain amplifier to amplify subthreshold stimuli in AP firing18 ,20,43,44 ."
32385249
SCN11A affects tat
| 1
SCN11A binds tat. 1 / 1
| 1
sparser
"Surprisingly, in the absence of Tat expression, addition of NaN 3 was associated with derepression of basal HIV promoter activity ( xref )."
22140357
SCN11A affects signals
| 1
SCN11A inhibits signals. 1 / 1
| 1
sparser
"Furthermore, these signals could be inhibited partially by NaN 3 and (in the absence of Na + ) completely by DCCD ( Fig. 7 C )."
12944317
SCN11A affects signal
| 1
SCN11A inhibits signal. 1 / 1
| 1
sparser
"The signal could be inhibited by 80% using 1 mM NaN 3 (F 1 inhibitor) in the presence of Na + ( Fig. 2, B and C )."
12944317
SCN11A affects rose bengal
| 1
SCN11A inhibits rose bengal. 1 / 1
| 1
sparser
"The prevention of RB inhibition by NaN 3 and histidine suggests that part of the inhibition by RB depended upon 1 O 2 originating on RB molecules activated by light xref shows inhibition of the increase by RB in D 2 O solution and comparison of the activity in water and D 2 O, and the result shows that the activity in D 2 O is approximately half of the activity in H 2 O. This may be because part of this decrease (increase of inhibition by RB) in activity depends upon the long presence (slow disappearance) of 1 O 2 in D 2 O solution, as well as the slightly higher viscosity of D 2 O solution."
20041016
SCN11A affects rGO
| 1
SCN11A inhibits rGO. 1 / 1
| 1
reach
"Additionally, the presence of SnS 2 particles prevents the restacking of rGO which in turn acts as a mechanical support for the SnS 2 particles."
28804530
SCN11A affects pyraclofos
| 1
SCN11A activates pyraclofos. 1 / 1
| 1
reach
"Congenital insensitivity to pain : Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage gated sodium channel 1.9."
26746779
SCN11A affects polonium atom
| 1
SCN11A activates polonium atom. 1 / 1
| 1
reach
"Although P was not growth limiting, HNAN accelerated the mineralization of PO (4)-P from dissolved organic matter by 600%."
16347801
SCN11A affects phosphatidic acid
| 1
Phosphatidic acid binds SCN11A. 1 / 1
| 1
sparser
"Similarly, using surface plasmon resonance, we were not able to detect any specific binding of Nan PA subunit to a DNA substrate using 1 μM protein (data not shown)."
22841552
SCN11A affects phase
| 1
SCN11A activates phase. 1 / 1
| 1
eidos
"To date , no evidence has shown that Nav1.9 contributes to the rising phase ."
32385249
SCN11A affects phagocytosis
| 1
SCN11A inhibits phagocytosis. 1 / 1
| 1
sparser
"Felipe, I.; Bochio, E. E.; Martins, N. B.; Pacheco, C. Inhibition of macrophage phagocytosis of Escherichia coli by mannose and man nan."
8971938
SCN11A affects oxidative phosphorylation
| 1
SCN11A inhibits oxidative phosphorylation. 1 / 1
| 1
sparser
"Only if oxidative phosphorylation is inhibited by NaN 3 , the ADP concentration in the medium increases with time, as expected, due to the MgATPase activities of fibers."
11245802
SCN11A affects nitric oxide
| 1
SCN11A activates nitric oxide. 1 / 1
| 1
reach
"Deletion of the Scn11a gene in MOH mice abrogates NO mediated symptoms, including cephalic and extracephalic allodynia, photophobia and phonophobia."
31534133
SCN11A affects nirS
| 1
SCN11A inhibits nirS. 1 / 1
| 1
sparser
"Inhibition of cytochrome oxidase-antibody complex by NaN3."
4322293
SCN11A affects mAb
| 1
SCN11A inhibits mAb. 1 / 1
| 1
eidos
"This mAb has identical reactivity as the CD60 b mAb UM4D4 and was applied because NaN 3 - free mAb UM4D4 was not available ."
17115281
SCN11A affects localization
| 1
SCN11A inhibits localization. 1 / 1
| 1
sparser
"This localization is inhibited by NaN3, but not by colchicine or cytochalasin D. Fc epsilon RI crosslinking also promotes internalization of this novel membrane component."
1831652
SCN11A affects lithium(1+)
| 1
SCN11A activates lithium(1+). 1 / 1
| 1
reach
"This leads to the utilization of both conversion and alloying reactions in SnS 2 that greatly increases lithium storage capability of SnS 2."
28102356
SCN11A affects killing
| 1
SCN11A inhibits killing. 1 / 1
| 1
sparser
"In the case of E. coli the inhibition of killing by NaN 3 was almost complete (4–5 logs) and was similar for wash and no wash."
23044264
SCN11A affects ion channel
| 1
SCN11A leads to the phosphorylation of ion channel. 1 / 1
| 1
reach
"This occurs at least in part via EP receptor mediated activation of intracellular kinases in the nociceptor terminal that causes phosphorylation of the nociceptive ion channel TRPV1 XREF_BIBR XREF_BIBR and an up-regulation of Nav1.9 voltage gated sodium channel (SCN11A) XREF_BIBR, which is then transported to peripheral nerve terminals to contribute to increased excitability XREF_BIBR."
28281561
SCN11A affects internalization
| 1
SCN11A inhibits internalization. 1 / 1
| 1
sparser
"Importantly, NAN inhibited etorphine-induced MOR internalization, indicating that it acts as an antagonist of agonist-induced internalization ( xref )."
30758946
SCN11A affects induction
| 1
SCN11A inhibits induction. 1 / 1
| 1
sparser
"Lead-induced DNA breakage was markedly enhanced by H2O2, and this induction was inhibited by NaN3, TEMP, EDTA, catalase, BSA, and glutathione."
10334621
SCN11A affects endocytosis
| 1
SCN11A inhibits endocytosis. 1 / 1
| 1
sparser
"In contrast, cells exposed to viscumin in the presence of 2-deoxyglucose and NaN3, which inhibit endocytosis, were not intoxicated when the cells were treated with antiviscumin and then transferred to normal medium."
7142145
SCN11A affects conversion
| 1
SCN11A inhibits conversion. 1 / 1
| 1
sparser
"A 10 times excess of tibolone and its metabolites did not inhibit the conversion of androstenedione to estrone by human recombinant aromatase as determined by estradiol receptor assay whereas T, MT, Nan, and MENT inhibited the conversion for 75, 53, 85 and 67%, respectively."
12628686
SCN11A affects cleavage
| 1
SCN11A inhibits cleavage. 1 / 1
| 1
sparser
"The induced DNA strand cleavage was inhibited by NaN3."
16149731
SCN11A affects biosynthetic process
| 1
SCN11A inhibits biosynthetic process. 1 / 1
| 1
sparser
"Prostaglandin biosynthesis in the same system is also inhibited by 3-amino-1,2,4-triazole (AT) and NaN3, reagents which function as heme enzyme inhibitors."
4457956
SCN11A affects activities
| 1
SCN11A inhibits activities. 1 / 1
| 1
sparser
"As mentioned in section 2.7, if the microbial activities of periphyton were completely inhibited by NaN 3 , the removal of MB under this condition was mainly due to adsorption process; on the contrary, if the periphyton was not inhibited, the removal of MB may be both due to adsorption and biodegradation."
28852105
SCN11A affects TiO 2 -SnS 2 -COMM
| 1
SCN11A activates TiO 2 -SnS 2 -COMM. 1 / 1
| 1
reach
"However, the increase in SnS 2 content increased effectiveness of process using TiO 2 -SnS 2 -COMM almost linearly reaching 81% and 67% of DCF removal and conversion, respectively, at pH 4 and 50 wt% of SnS 2 (XREF_FIG)."
29921795
SCN11A affects ST14
| 1
SCN11A binds ST14. 1 / 1
| 1
sparser
"Healthy mandarin fish (weight ∼250 g) were obtained from a fish farm in Nan-Hai (Guangdong Province, China) and maintained for at least 2 weeks in aquaria at 28 • C. Freshly dissected tissues, including brain, fat tissue, heart, hemocytes, gills, intestines, liver, muscle, kidney, and spleen, were washed thoroughly with phosphate buffered saline (PBS) and immediately homogenized with thiourea lysis buffer (7 M urea, 2 M thiourea, 4% CHAPS) containing protease inhibitor cocktail set III (Calbiochem, USA)."
21296425
SCN11A affects SPARC
| 1
SCN11A inhibits SPARC. 1 / 1
| 1
reach
"At negative gate voltage (V g), the gating depletes the n-type SnS 2 nanosheet, decreasing the dark current, operating in OFF mode; by increasing V g, the SnS 2 channel falls in the accumulation region, increasing the dark current and operating in the ON state."
30167178
SCN11A affects SOD
| 1
SCN11A inhibits SOD. 1 / 1
| 1
sparser
"The SOD was inhibited only by NaN(3), which suggested that this SOD is of the manganese superoxide dismutase type."
20703805
SCN11A affects SH3BP1
| 1
SCN11A activates SH3BP1. 1 / 1
| 1
sparser
"Sh3bp1 is ectopically activated by Nan-KLF1; it is a RhoGAP protein normally expressed by neural tissues (Figure xref ) ( xref )."
28180284
SCN11A affects SH3BGRL3
| 1
SCN11A activates SH3BGRL3. 1 / 1
| 1
sparser
"Sh3bp1 is ectopically activated by Nan-KLF1; it is a RhoGAP protein normally expressed by neural tissues (Figure xref ) ( xref )."
28180284
SCN11A affects SGR
| 1
SCN11A binds SGR. 1 / 1
| 1
sparser
"Transcript profiling indicated that a SGR -like ( STAY-GREEN ) gene was expressed at lower levels in nan flavedo, suggesting that nan mutation could be associated to a SGR -like upstream regulatory factor [ xref ]."
21159189
SCN11A affects NLRP1
| 1
SCN11A binds NLRP1. 1 / 1
| 1
sparser
"This is in contrast to the findings of Perreault and co-workers, who observed hydroxylamine acetylation with subsequent de-hydroxylation to form 2-NAc-NAN ( xref )."
27913891
SCN11A affects NAV1
| 1
SCN11A activates NAV1. 1 / 1
| 1
reach
"[XREF_BIBR, XREF_BIBR] Recent studies in humans have indicated that Nav1.9 dysfunction caused by certain SCN11A variants associated with a series of pain disorders."
28953656
SCN11A affects MPO
| 1
SCN11A binds MPO. 1 / 1
| 1
sparser
"Results indicated that NaN 3 binding to the MPO enzyme was itself reversible as near complete fluorogenic potential was recovered (see the difference between progress curves b and c in xref )."
24632143
SCN11A affects LGI1
| 1
SCN11A inhibits LGI1. 1 / 1
| 1
sparser
"Partial inhibition by NaN 3 was also observed on BLM and by other authors ( Laubinger and Dimroth, 1988 )."
12944317
SCN11A affects IRF7
| 1
SCN11A activates IRF7. 1 / 1
| 1
sparser
"These data indicate that Hamp and Irf7 are ectopically activated by Nan-KLF1 in fetal liver, as neither is normally expressed in erythroid cells xref , xref ."
30143664
SCN11A affects HPS6
| 1
SCN11A binds HPS6. 1 / 1
| 1
sparser
"February 15, 2013 . www.wjpch.com Common WU polyomavirus infection in a Beijing population indicated by surveillance for serum IgG antibody against capsid protein VP2Ni-Na Zhang, Lin-Qing Zhao, Yuan Qian, Ru-Nan Zhu, Jie Deng, Fang Wang, Yu Sun, Li-Ying Liu World J Pediatr, Vol 9 No 1 ."
23389332
SCN11A affects HAMP
| 1
SCN11A activates HAMP. 1 / 1
| 1
sparser
"These data indicate that Hamp and Irf7 are ectopically activated by Nan-KLF1 in fetal liver, as neither is normally expressed in erythroid cells xref , xref ."
30143664
SCN11A affects Fa
| 1
SCN11A binds Fa. 1 / 1
| 1
sparser
"Guangxi Zhuang Autonomous Region: Guilin Botanical Garden (cultivated; introduced from Napo County, W Guangxi), 3 June 1991, Wei Fa-nan 1910 (holotype: IBK n."
32405244
SCN11A affects FGF14
1 |
SCN11A binds FGF14. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN11A affects FGF13
1 |
SCN11A binds FGF13. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN11A affects FGF12
1 |
SCN11A binds FGF12. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN11A affects FGF11
1 |
SCN11A binds FGF11. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN11A affects DNA Damage
| 1
SCN11A inhibits DNA Damage. 1 / 1
| 1
sparser
"However, such H 2 O 2 -mediated damage was not inhibited by NaN 3 or taurine (Figure  xref )."
24915973
SCN11A affects CD59
| 1
Mutated SCN11A activates CD59. 1 / 1
| 1
reach
"In 2013, heterozygous gain-of-function mutation of SCN11A on chromosome 3p21-24 was discovered by Leipold et al to cause CIP."
26746779
SCN11A affects CC
| 1
SCN11A activates CC. 1 / 1
| 1
reach
"In the developing CC, hypothyroidism initially increases area and cellularity by PN5, but then ultimately decreases area and cellularity by PN50."
15256491
SCN11A affects Action potential
1 |
SCN11A activates Action potential. 1 / 1
1 |
signor
"The expression of voltage-gated sodium channels (NaVs) is a key feature for initiation and conduction of action potentials in excitable tissues and cells such as cardiac and skeletal muscle and neurons."
26043074
SCN11A affects ATP4A
| 1
SCN11A inhibits ATP4A. 1 / 1
| 1
sparser
"The proton pump was inhibited by dicyclohexylcarbodiimide, venturicidin and NaN3."
1826099
SCN11A affects ATP12A
| 1
SCN11A inhibits ATP12A. 1 / 1
| 1
sparser
"The proton pump was inhibited by dicyclohexylcarbodiimide, venturicidin and NaN3."
1826099
SCN11A affects ALB
| 1
SCN11A binds ALB. 1 / 1
| 1
sparser
"As with [125I]IGF-II, binding of the 125I-labeled polyman- nan-BSA was lower after acid acetate prewashes, indi- cating that the effect of acetate upon the IGF-II/M6P receptor was independent of the nature of the ligand binding to this receptor (Table 1)."
8086486
S and sigma affects SCN11A
| 1
S and sigma inhibits SCN11A. 1 / 1
| 1
reach
"By diminishing the thickness of SnS 2 nanosheet to about 3L, the S and sigma along a direction simultaneously increase whereas kappa decreases, achieving a high ZT value of 1.87 at 800K."
28827756
RAC1 affects SCN11A
| 1
RAC1 activates SCN11A. 1 / 1
| 1
reach
"The expression of Rac1 and Pak3 mRNA increases from PN3 to PN5."
28408954
PF affects SCN11A
| 1
PF activates SCN11A. 1 / 1
| 1
reach
"No significant difference in the expression of these target genes were seen in cells treated with NN-PF and cells treated with YY-PF or YN-PF, but there was a trend towards higher expression of CNR1 and SCN11A in cells treated with PF from endometriosis patients (YY-PF and YN-PF)."
28499250
PAK3 affects SCN11A
| 1
PAK3 activates SCN11A. 1 / 1
| 1
reach
"The expression of Rac1 and Pak3 mRNA increases from PN3 to PN5."
28408954
NPs affects SCN11A
| 1
NPs inhibits SCN11A. 1 / 1
| 1
reach
"Taking advantage of the excellent catalytic ability and biocompatibility, palladium nanoparticles (Pd NPs) were in situ reduced on SnS 2 NFs to obtain SnS 2 -Pd."
30928738
NLRP1 affects SCN11A
| 1
SCN11A binds NLRP1. 1 / 1
| 1
sparser
"This is in contrast to the findings of Perreault and co-workers, who observed hydroxylamine acetylation with subsequent de-hydroxylation to form 2-NAc-NAN ( xref )."
27913891
MPO affects SCN11A
| 1
SCN11A binds MPO. 1 / 1
| 1
sparser
"Results indicated that NaN 3 binding to the MPO enzyme was itself reversible as near complete fluorogenic potential was recovered (see the difference between progress curves b and c in xref )."
24632143
KOR affects SCN11A, TP53INP2, and mor
| 1
SCN11A binds TP53INP2, mor, and KOR. 1 / 1
| 1
sparser
"The binding modes of the NAN_MOR, NAN_KOR, and NAN_DOR complexes after 10 ns MD simulations are shown in xref , where it can be seen that NAN bound to the same binding domain of the MOR, KOR, and DOR."
30758946
IL10 affects SCN11A
1 |
Transcriptionally active IL10 decreases the amount of SCN11A. 1 / 1
1 |
signor
"Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α."
23357618
HTN3 affects SCN11A, and pan
| 1
SCN11A binds HTN3 and pan. 1 / 1
| 1
sparser
"Similarly, Pb levels were significantly associated with both NAN and PAN indices ( p -values <0.0002), and the associations remained consistent for all quantiles of Pb."
28438148
HPS6 affects SCN11A
| 1
SCN11A binds HPS6. 1 / 1
| 1
sparser
"February 15, 2013 . www.wjpch.com Common WU polyomavirus infection in a Beijing population indicated by surveillance for serum IgG antibody against capsid protein VP2Ni-Na Zhang, Lin-Qing Zhao, Yuan Qian, Ru-Nan Zhu, Jie Deng, Fang Wang, Yu Sun, Li-Ying Liu World J Pediatr, Vol 9 No 1 ."
23389332
Fig.2e-g affects SCN11A
| 1
Fig.2e-g activates SCN11A. 1 / 1
| 1
eidos
"HpTx1 evoked robust pain responses and produced profound hypersensitivity to mechanical and thermal stimuli in Nav1.7-KO mice ( Fig.1c-e ) , as revealed by the depolarized RMP , reduced rheobase and increased AP firing in some small DRG neurons with Nav1.9 activation by HpTx1 ( Fig.2e-g ) ."
32385249
Fa affects SCN11A
| 1
SCN11A binds Fa. 1 / 1
| 1
sparser
"Guangxi Zhuang Autonomous Region: Guilin Botanical Garden (cultivated; introduced from Napo County, W Guangxi), 3 June 1991, Wei Fa-nan 1910 (holotype: IBK n."
32405244
ESR2 affects SCN11A
1 |
Transcriptionally active ESR2 decreases the amount of SCN11A. 1 / 1
1 |
signor
"17β-Estradiol regulates the gene expression of voltage-gated sodium channels. . In this study, we investigate the mRNA expressions of Nav channel subtypes mediated differentially by the ERs in the DRGs of wild-type (WT) and estrogen receptor knockout (αERKO and βERKO) mice. In the present study, by means of quantitative real-time PCR, we found that the expressions of Nav1.1, Nav1.7, Nav1.8, and Nav1.9 subtypes were elevated in αERKO and βERKO mice"
22169964
ESR1 affects SCN11A
1 |
Transcriptionally active ESR1 decreases the amount of SCN11A. 1 / 1
1 |
signor
"17β-Estradiol regulates the gene expression of voltage-gated sodium channels. . In this study, we investigate the mRNA expressions of Nav channel subtypes mediated differentially by the ERs in the DRGs of wild-type (WT) and estrogen receptor knockout (αERKO and βERKO) mice. In the present study, by means of quantitative real-time PCR, we found that the expressions of Nav1.1, Nav1.7, Nav1.8, and Nav1.9 subtypes were elevated in αERKO and βERKO mice"
22169964
COX4I1 affects PPARGC1A, and SCN11A
| 1
SCN11A binds COX4I1 and PPARGC1A. 1 / 1
| 1
sparser
"The results suggested that the NaN 3 -induced apoptosis was associated with the expression levels of Pgc-1α family proteins and Cox IV in mitochondria-mediated signaling pathway."
30664159
CD59 affects SCN11A
| 1
CD59 inhibits SCN11A. 1 / 1
| 1
reach
"In this work, CIP was photocatalytically degraded using a porous ZnO and SnS 2 photocatalyst prepared via microwaves."
32304862
CB affects SCN11A
| 1
CB activates SCN11A. 1 / 1
| 1
reach
"Both VB and CB potentials of SnS 2 are more negative than those of TiO 2 due to which photogenerated electrons are transferred efficiently from the CB of SnS 2 to that of TiO 2 under irradiation of visible light, and the photogenerated holes remain on the VB of SnS 2 [XREF_BIBR]."
29977679
APC affects SCN11A
| 1
APC activates SCN11A. 1 / 1
| 1
reach
"At the postnatal phase, APC expression increased from PN1 to PN5, but the expression level at PN7 was reduced compared with PN5."
28782241
ALB affects SCN11A
| 1
SCN11A binds ALB. 1 / 1
| 1
sparser
"As with [125I]IGF-II, binding of the 125I-labeled polyman- nan-BSA was lower after acid acetate prewashes, indi- cating that the effect of acetate upon the IGF-II/M6P receptor was independent of the nature of the ligand binding to this receptor (Table 1)."
8086486
3alpha-hydroxy-5beta-pregnan-20-one affects SCN11A
| 1
3alpha-hydroxy-5beta-pregnan-20-one activates SCN11A. 1 / 1
| 1
reach
"The addition of 1 microM pregnanolone induced a 3-6-fold increase [3H] muscimol affinity in PN5 (n = 3; P < 0.03), and a 2-fold increase in receptors number in adults (n = 3; P < 0.03)."
9220465