INDRA statements for SCN10A

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phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
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SCN10A affects sodium(1+)
1 | 11
SCN10A activates sodium(1+).
| 10
SCN10A activates sodium(1+). 10 / 10
| 10
reach
"(2) SNS and PN3, M 1 2 3 4 5 6 7 8 9 M 200 which is expressed preferentially in small DRG and trigeminal neurons, produces a sodium current that is relatively resistant to TTX (Akopian et al., 1996; Sangameswaran et al., 1996)."
11098678
reach
"SCN10A and Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation."
25053638
reach
"We hypothesize that SCN10A modulates the activity of the canonical cardiac sodium channel encoded by SCN5A in the heart."
24998131
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"64 More recently rare variants in SCN10A, encoding the Nav1.8 sodium channel, have not only been associated with AF but also shown to modulate both the peak and late sodium current (I Na-L) (XREF_TABLE)."
25970841
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"Blocking SCN10A channels in heart reduces late sodium current and is antiarrhythmic."
22723299
reach
"Heterologous coexpression of wild-type (WT) SCN10A with WT-SCN5A in HEK cells caused a near doubling of sodium channel current compared with WT-SCN5A alone."
24998131
reach
"The novel sodium channel PN3 and alpha-SNS, which was cloned from a rat dorsal root ganglion (DRG) cDNA library, is expressed predominantly in small sensory neurons and may contribute to the tetrodotoxin resistant (TTXR) sodium current that is believed to be associated with central sensitization in chronic neuropathic pain states."
9482802
reach
"(2) SNS and PN3, M 1 2 3 4 5 6 7 8 9 M 200 which is expressed preferentially in small DRG and trigeminal neurons, produces a sodium current that is relatively resistant to TTX (Akopian et al., 1996; Sangameswaran et al., 1996)."
11098678
reach
"Heterologous co-expression of wild-type (WT) SCN10A with WT-SCN5A in HEK cells caused a near doubling of sodium channel current (I Na) compared with WT-SCN5A alone."
24998131
reach
"Genetic knockout of murine Scn10a also attenuate late sodium current in mouse cardiomyocytes."
24721653
SCN10A inhibits sodium(1+).
| 1
SCN10A inhibits sodium(1+). 1 / 1
| 1
reach
"Furthermore, they demonstrated that the SCN10A variants R1268Q and R14L reduced cardiac sodium currents."
27200363
SCN10A increases the amount of sodium(1+).
1 |
SCN10A increases the amount of sodium(1+). 1 / 1
1 |
signor
"Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential."
27262167
Cre affects SCN10A
| 11
SCN10A binds cre. 11 / 11
| 11
sparser
"In Nav1.8-Cre +/− ; Dta mice, compared with control littermates, we also observed significantly greater bacterial dissemination to the blood, which was accompanied by greater spleen size (Supplementary Fig. 13 )."
29505031
sparser
"Nav1.8-cre mice21 were originally from J. Wood (University College London)."
29505031
sparser
"Dta +/+ mice to generate Nav1.8-cre +/− ; Dta mice and control littermates (Nav1.8-cre −/− ; Dta)."
29505031
sparser
"Nav1.8-cre +/− mice were bred with diphtheria toxin A (DTA) reporter mice to generate animals deficient in Nav1.8-lineage neurons (Nav1.8-Cre +/− ; Dta) 21 ."
29505031
sparser
"We found a similar increase in γδ T cells in Nav1.8-Cre +/− ; Dta mice compared with control littermates (Supplementary Fig. 24 ). γδ T cells reside within epithelial layers of the lungs, skin, and gut, where they act as first responders to infection 27 ."
29505031
sparser
"Another study has shown that Nav1.8-Cre; Dta mice still possess CGRP+ neurons expressing TRPV1 (ref."
29505031
sparser
"Nav1.8-cre +/− mice were bred with B6."
29505031
sparser
"After MRSA infection, we observed a trend toward higher survival (P = 0.09) and lower bacterial burden (P = 0.07) in Nav1.8-Cre +/− ; Dta mice than in control littermates (Supplementary Fig. 8) ."
29505031
sparser
"Nav1.8-cre; Dta mice, in which an overlapping though distinct nociceptor subset is targeted, showed a milder protective phenotype."
29505031
sparser
"An alternative germline model of sensory nerve Y2R knockdown was generated using Nav1.8-Cre mice crossed with the Y2R-flox strain (Nav1.8-Y2R-KD)."
| PMC
sparser
"An alternative germline model of sensory nerve Y2R knockdown was generated using Nav1.8-Cre mice crossed with the Y2R-flox strain (Nav1.8-Y2R-KD)."
| PMC
Sodium_channels affects SCN10A
| 8
Sodium_channels binds SCN10A.
| 5
Sodium_channels binds SCN10A and bop. 2 / 2
| 2
sparser
"Variants in CACNA1C (Cav1.2), CACNB2b (CavB2b) and CACNA2D1 (Cavα2δ) have been reported in up to 13% of probands. [ xref – xref ] Mutations in glycerol-3-phophate dehydrogenase 1- like enzyme gene (GPD1L), SCN1B (β1-subunit of Na channel), KCNE3 (MiRP2), SCN3B (β3- subunit of Na channel), KCNJ8 (Kir6.1), KCND3 (Kv4.3), RANGRF (MOG1), SLMAP, ABCC9 (SUR2A), SNC2B (Navβ2), PKP2 (Plakophillin-2), FGF12 (FHAF1), HEY2, and SEMA3A (Semaphorin) are relatively rare.[ xref – xref ] An association of BrS with SCN10A, a neuronal sodium channel, was recently reported.[ xref , xref ]"
29757020
sparser
"An association of BrS with SCN10A , a neuronal sodium channel, was recently reported xref , xref , xref ."
27761155
Sodium_channels binds SCN10A. 1 / 1
| 1
sparser
"Voltage-gated sodium channel mutations are associated with different seizure phenotypes including benign familial neonatal-infantile convulsions, genetic epilepsy with febrile seizures plus, and Dravet syndrome."
25194485
Sodium_channels binds SCN10A and FGF14. 1 / 1
| 1
sparser
"The mutant FGF14 protein fails to interact with sodium channel subunits, and interferes with the interaction between wild-type FGF14 and voltage-gated sodium channel subunits in a dominant manner xref ."
19822774
Sodium_channels binds SCN10A, SCN5A, and PSMD4. 1 / 1
| 1
sparser
"SCN5A and SCN10A cardiac sodium channel related genes are associated with AF."
25054116
Sodium_channels activates SCN10A.
| 2
Sodium_channels activates SCN10A. 2 / 2
| 2
sparser
"Voltage-gated sodium channel activation is characterized by transient inward, rapidly inactivating ionic currents."
29581437
sparser
"Voltage-gated sodium channel activation leads to increased Na + influx, which has the capability to increase [Ca 2+ ] i via the reverse mode of NCX."
24740847
Sodium_channels inhibits SCN10A.
| 1
Sodium_channels inhibits SCN10A. 1 / 1
| 1
sparser
"In particular, neurons that receive input that induces large inward currents (hyperexcitation) may display depolarization block, and be unable to fire APs due to voltage–gated sodium channel inactivation."
23990770
NGF affects SCN10A
1 | 7
NGF increases the amount of SCN10A.
1 | 4
NGF increases the amount of SCN10A. 5 / 5
1 | 4
bel
"As expected, NGF increased expression of the voltage-gated sodium channel SNS1/PN3 in this system."
11844726
reach
"Black et al. (1997) studied an in vitro model that mimics axotomy, and demonstrated that NGF, delivered directly to DRG cell bodies in vitro, down-regulates a-III mRNA and up-regulates SNS and PN3 mRNA expression in small DRG neurons."
11098678
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"We confirm that NGF restores SNS and PN3 mRNA levels in DRG neurons in vitro and demonstrate that the trk antagonist K252a blocks this rescue."
10216225
reach
"We confirm that NGF restores SNS and PN3 mRNA levels in DRG neurons in vitro and demonstrate that the trk antagonist K252a blocks this rescue."
10216225
reach
"Black et al. (1997) studied an in vitro model that mimics axotomy, and demonstrated that NGF, delivered directly to DRG cell bodies in vitro, down-regulates a-III mRNA and up-regulates SNS and PN3 mRNA expression in small DRG neurons."
11098678
NGF activates SCN10A.
| 2
NGF activates SCN10A. 2 / 2
| 2
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"While infusion of exogenous NGF to the transected nerve restores SNS and PN3 transcripts to near-normal levels in small DRG neurons, TTX-R sodium currents are only partially rescued."
10216225
reach
"While infusion of exogenous NGF to the transected nerve restores SNS and PN3 transcripts to near-normal levels in small DRG neurons, TTX-R sodium currents are only partially rescued."
10216225
NGF decreases the amount of SCN10A.
| 1
NGF decreases the amount of SCN10A. 1 / 1
| 1
reach
"In vivo NGF deprivation reduces SNS expression and TTX-R sodium currents in IB4 negative DRG neurons."
10036280
Bop affects SCN10A
| 7
SCN10A binds bop. 4 / 4
| 4
sparser
"Variants in genes encoding the calcium channels including CACNA1C (Cav1.2), CACNB2b (Cavβ2b) and CACNA2D1 (Cavα2δ) have been reported in up to 13% of probands. xref – xref Mutations in glycerol-3-phophate dehydrogenase 1-like enzyme gene ( GPD1L ), SCN1B (β 1 -subunit of Na channel), KCNE3 (MiRP2), SCN3B (β3-subunit of Na channel), KCNJ8 (Kir 6.1), KCND3 (Kv4.3), RANGRF (MOG1), SLMAP , ABCC9 (SUR2A), (Navβ2), PKP2 (Plakophillin-2), FGF12 (FHAF1), HEY 2, SEMA3A (Semaphorin) and KCNAB2 (Kvβ2) are relatively rare. xref – xref An association of BrS with SCN10A , a gene encoding a neuronal Na channel, was reported in 2014. xref , xref , xref There is controversy as to the pathogenicity of many SCN10A mutation with yields ranging between 5% and 16.7%. xref – xref Mutations in all of these genes lead to loss of function in sodium (I Na ) and calcium (ICa) channel currents, as well as to a gain of function in transient outward potassium current (I to ) or ATP-sensitive potassium current (IK-ATP). xref , xref "
29870068
sparser
"Recently, genome-wide association studies identified SCN10A , the gene encoding Na v 1.8, as a determinant of cardiac conduction parameters, and mutations in SCN10A have been associated with BrS."
25780798
sparser
"For example, the Na v 1.8 blocker A-803467 shortened action potentials in cardiomyocytes, and PR intervals were shorter in Scn10a −  /  − mice, suggesting that Na v 1.8 acts to lengthen cardiac conduction. xref , xref However, in mice treated with A-803467, QRS and PR were longer, and mutations in SCN10A were associated with BrS, suggesting acceleration of impulse propagation by Na v 1.8. xref , xref It is possible that numerous factors have to be considered in future experiments to solve this fascinating puzzle, like a possible alternative splicing in the heart, a species-dependent regulation of expression, the turn-over of the protein, a possible inducible expression under certain conditions, the cell-specificity of expression in different cardiac cells of higher mammals, essential interactions of Na v 1.8 with other cardiac proteins, or the role of SCN10A /Na v 1.8 in the diseased myocardium using animal models."
25780798
sparser
"To date more than 300 BrS-related mutations in SCN5A have been described xref , xref , xref Mutations in CACNA1C (Cav1.2), CACNB2b (Cavß2b) and CACNA2D1 (Cavα2δ) are found in approximately 13% of probands. xref - xref Mutations in glycerol-3-phophate dehydrogenase 1-like enzyme gene ( GPD1L ), SCN1B (β 1 -subunit of Na channel), KCNE3 (MiRP2), SCN3B (β3-subunit of Na channel), KCNJ8 (Kir 6.1), KCND3 (Kv4.3), RANGRF (MOG1), SLMAP , ABCC9 (SUR2A), (Navß2), PKP2 (Plakophillin-2), FGF12 (FHAF1), HEY 2, and SEMA3A (Semaphorin) are more rare. xref - xref xref - xref xref , xref - xref We recently reported an association of BrS with SCN10A , a neuronal sodium channel that co-associates with SCN5A , with a yield of 16.7%. xref Mutations in these genes lead to loss of function in sodium channel current (I Na ) and calcium channel current (I Ca ), as well as to a gain of function in transient outward potassium current (I to ) or ATP-sensitive potassium current (I K-ATP )."
25869754
Sodium_channels binds SCN10A and bop. 2 / 2
| 2
sparser
"Variants in CACNA1C (Cav1.2), CACNB2b (CavB2b) and CACNA2D1 (Cavα2δ) have been reported in up to 13% of probands. [ xref – xref ] Mutations in glycerol-3-phophate dehydrogenase 1- like enzyme gene (GPD1L), SCN1B (β1-subunit of Na channel), KCNE3 (MiRP2), SCN3B (β3- subunit of Na channel), KCNJ8 (Kir6.1), KCND3 (Kv4.3), RANGRF (MOG1), SLMAP, ABCC9 (SUR2A), SNC2B (Navβ2), PKP2 (Plakophillin-2), FGF12 (FHAF1), HEY2, and SEMA3A (Semaphorin) are relatively rare.[ xref – xref ] An association of BrS with SCN10A, a neuronal sodium channel, was recently reported.[ xref , xref ]"
29757020
sparser
"An association of BrS with SCN10A , a neuronal sodium channel, was recently reported xref , xref , xref ."
27761155
SCN10A binds NAV1, bop, and SNP. 1 / 1
| 1
sparser
"The common SNP SCN10A V1073 was strongly associated with BrS and demonstrated loss of NaV1.8 function, as did rare variants in isolated patients."
25691538
SCN10A affects sodium atom
| 1 4
SCN10A activates sodium atom.
| 2
SCN10A activates sodium atom. 2 / 2
| 2
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"The remarkable conservation of the S4 sequence, including all the charged residues, suggests that this segment does not confer slow activation and inactivation and rapid repriming on the Na current produced by SNS.The D4S3-S4 linker of SNS and PN3 is remarkably divergent from other subfamily 1 channels."
9369222
reach
"The remarkable conservation of the S4 sequence, including all the charged residues, suggests that this segment does not confer slow activation and inactivation and rapid repriming on the Na current produced by SNS.The D4S3-S4 linker of SNS and PN3 is remarkably divergent from other subfamily 1 channels."
9369222
SCN10A inhibits sodium atom.
| 1
SCN10A inhibits sodium atom. 1 / 1
| 1
reach
"In this study, we used sensory neuron specific (SNS) sodium channel gene knockout (-/-) mice to ask whether SNS sodium channel produces the slow Na (+) current (" slow ") in large (> 40 microm diam) cutaneous afferent dorsal root ganglion (DRG) neurons."
10938298
SCN10A increases the amount of sodium atom.
| 1
SCN10A increases the amount of sodium atom. 1 / 1
| 1
reach
"The present study examines the hypothesis that variations in SCN10A contribute to BrS by modulating the expression of Na v 1.5 current, the principal cardiac sodium channel."
24998131
SCN10A binds sodium atom.
| 1
Sodium atom binds SCN10A. 1 / 1
| 1
sparser
"Voltage-gated sodium (Na V ) channels are heteromeric transmembrane proteins that consist of a single pore forming α-subunit associated with one or more auxiliary β-subunits (Na V βs) [ xref ]."
30814913
SCN10A affects Sodium_channels
| 5
Sodium_channels binds SCN10A and bop. 2 / 2
| 2
sparser
"Variants in CACNA1C (Cav1.2), CACNB2b (CavB2b) and CACNA2D1 (Cavα2δ) have been reported in up to 13% of probands. [ xref – xref ] Mutations in glycerol-3-phophate dehydrogenase 1- like enzyme gene (GPD1L), SCN1B (β1-subunit of Na channel), KCNE3 (MiRP2), SCN3B (β3- subunit of Na channel), KCNJ8 (Kir6.1), KCND3 (Kv4.3), RANGRF (MOG1), SLMAP, ABCC9 (SUR2A), SNC2B (Navβ2), PKP2 (Plakophillin-2), FGF12 (FHAF1), HEY2, and SEMA3A (Semaphorin) are relatively rare.[ xref – xref ] An association of BrS with SCN10A, a neuronal sodium channel, was recently reported.[ xref , xref ]"
29757020
sparser
"An association of BrS with SCN10A , a neuronal sodium channel, was recently reported xref , xref , xref ."
27761155
Sodium_channels binds SCN10A. 1 / 1
| 1
sparser
"Voltage-gated sodium channel mutations are associated with different seizure phenotypes including benign familial neonatal-infantile convulsions, genetic epilepsy with febrile seizures plus, and Dravet syndrome."
25194485
Sodium_channels binds SCN10A and FGF14. 1 / 1
| 1
sparser
"The mutant FGF14 protein fails to interact with sodium channel subunits, and interferes with the interaction between wild-type FGF14 and voltage-gated sodium channel subunits in a dominant manner xref ."
19822774
Sodium_channels binds SCN10A, SCN5A, and PSMD4. 1 / 1
| 1
sparser
"SCN5A and SCN10A cardiac sodium channel related genes are associated with AF."
25054116
SCN10A affects tetrodotoxin
| 4
SCN10A activates tetrodotoxin.
| 3
SCN10A activates tetrodotoxin. 3 / 3
| 3
reach
"The novel sodium channel PN3 and alpha-SNS, which was cloned from a rat dorsal root ganglion (DRG) cDNA library, is expressed predominantly in small sensory neurons and may contribute to the tetrodotoxin resistant (TTXR) sodium current that is believed to be associated with central sensitization in chronic neuropathic pain states."
9482802
reach
"Na channel subunits alphaSNS (PN3) and alpha mu1 (SkM1) produce slowly inactivating and TTX resistant and rapidly inactivating and TTX sensitive currents, respectively."
9369222
reach
"TTX resistance is predominantly mediated by SCN10A (also known as Na V 1.8)."
25420069
SCN10A inhibits tetrodotoxin.
| 1
SCN10A inhibits tetrodotoxin. 1 / 1
| 1
reach
"Na channel subunits alphaSNS (PN3) and alpha mu1 (SkM1) produce slowly inactivating and TTX resistant and rapidly inactivating and TTX sensitive currents, respectively."
9369222
SCN10A affects MITF
| 4
SCN10A decreases the amount of MITF.
| 3
SCN10A decreases the amount of MITF. 3 / 3
| 3
reach
"As shown in XREF_FIG, the expression level of MITF was reduced by PN3 in a dose dependent manner."
29385729
reach
"Compared to the control, the expression levels of MITF were reduced by 89.36% and 99.08% at 25 and 100 mug/mL of PN3, respectively."
29385729
reach
"In this study, PN3 downregulated the expression of tyrosinase, TRP 1, TRP 2, and MITF."
29385729
SCN10A activates MITF.
| 1
SCN10A activates MITF. 1 / 1
| 1
reach
"PN3 could inhibit PKA and CREB and the subsequent degradation of microphthalmia associated transcription factor (MITF), resulting in the suppression of melanogenic enzymes and melanin production, probably because of the presence of flavonoid compounds."
29385729
Calcium_channels affects SCN10A
| 4
Calcium_channels activates SCN10A.
| 3
Calcium_channels activates SCN10A. 3 / 3
| 3
sparser
"It has been shown that induction of Npas4 mRNA depends on triad of NMDA receptor, AMPA receptor and voltage-gated calcium channel (VGCC) activation (Lin et al., xref )."
26633966
sparser
"Since in none of the treatment groups a correlation was observed we hypothesize that a direct effect, based on the simultaneous activation of the two different signaling pathways via the glucocorticoid receptor and voltage gated calcium channel activation, are responsible for the synergistic effect of DEX and ES on SGN survival."
28859106
sparser
"Indeed, tDCS effects have been associated with membrane depolarization-dependent increases in intracellular Ca 2+ levels via NMDAR and voltage-gated calcium channel activation ( xref )."
29997473
Calcium_channels inhibits SCN10A.
| 1
Calcium_channels inhibits SCN10A. 1 / 1
| 1
sparser
"Voltage-gated calcium channel inhibition by Dimebon."
18939977
P38 affects SCN10A
| 2 1
P38 phosphorylates SCN10A.
| 2
P38 phosphorylates SCN10A. 2 / 2
| 2
rlimsp
"It was reported that Nav1.8 and pp38 are colocalized in DRG neurons and p38 directly phosphorylates Nav1.8 to cause an increase in Nav1.8 current density23."
27708397
rlimsp
"Additionally, Nav1.8 within DRG neurons is a substrate for p38 mitogen-activated protein kinase (MAPK), and phosphorylation of Nav1.8 by p38 increases current density in these sensory neurons23."
27708397
P38 activates SCN10A.
| 1
P38 activates SCN10A. 1 / 1
| 1
reach
"Phosphorylation of Nrf2 in HepG2 cells was enhanced in PN3, which was mediated by PKCdelta, ERK, and p38 MAPK."
30626086
Ion channel affects SCN10A
| 3
SCN10A binds ion channel. 3 / 3
| 3
sparser
"Voltage-gated ion channels form a large superfamily including also CNG channels xref − xref that are opened by the binding of cyclic nucleotides with a gating, which is also voltage-dependent. xref CNG channels are formed by four subunits, either of type A (CNGA1, CNGA2, CNGA3, CNGA4, and CNGA5) or of type B (CNGB1 and CNGB2)."
31457189
sparser
"THE INTERACTIONS OF Zn^ WITH VOLTAGE-GATED ION CHANNELS Zn2* effects on voltage-sensitive Na+ channels There is a long history of work on the effects of Zn24 on Na4 channels."
7845550
sparser
"Voltage-gated ion channels form a large super-family with a common overall architecture derived from a common ancestor xref ."
29311674
TCF4 affects SCN10A
| 3
TCF4 binds SCN10A.
| 2
SCN10A binds TCF4. 2 / 2
| 2
reach
"These results in both human and rat indicate TCF4 directly binds to genomic regions within KCNQ1 and SCN10a and suggests TCF4 could directly regulate the expression of these genes."
26971948
reach
"To determine if TCF4 directly binds to KCNQ1 and SCN10a we first analyzed the publicly available ENCODE datasets of TCF4 ChIP-seq performed in human K562 cell line."
26971948
TCF4 decreases the amount of SCN10A.
| 1
TCF4 decreases the amount of SCN10A. 1 / 1
| 1
reach
"Together these results robustly validate our iTRAP method and suggest that under normal conditions, TCF4 represses the expression of KCNQ1 and SCN10a in layer 2/3 neurons of the rat prefrontal cortex."
26971948
SCN10A affects ion channel
| 3
SCN10A binds ion channel. 3 / 3
| 3
sparser
"Voltage-gated ion channels form a large superfamily including also CNG channels xref − xref that are opened by the binding of cyclic nucleotides with a gating, which is also voltage-dependent. xref CNG channels are formed by four subunits, either of type A (CNGA1, CNGA2, CNGA3, CNGA4, and CNGA5) or of type B (CNGB1 and CNGB2)."
31457189
sparser
"THE INTERACTIONS OF Zn^ WITH VOLTAGE-GATED ION CHANNELS Zn2* effects on voltage-sensitive Na+ channels There is a long history of work on the effects of Zn24 on Na4 channels."
7845550
sparser
"Voltage-gated ion channels form a large super-family with a common overall architecture derived from a common ancestor xref ."
29311674
SCN10A affects PSMD4
| 2 1
SCN10A binds PSMD4.
| 2
SCN10A binds PSMD4. 1 / 1
| 1
sparser
"Other sodium channel proteins are scarcely expressed in cardiomyocytes and have not been associated with the development of AF at this time."
26085805
Sodium_channels binds SCN10A, SCN5A, and PSMD4. 1 / 1
| 1
sparser
"SCN5A and SCN10A cardiac sodium channel related genes are associated with AF."
25054116
SCN10A activates PSMD4.
| 1
SCN10A activates PSMD4. 1 / 1
| 1
reach
"Common and Rare Variants in SCN10A Modulate the Risk of Atrial Fibrillation."
25691686
SCN10A affects NAV1
| 1 2
SCN10A inhibits NAV1.
| 1
SCN10A inhibits NAV1. 1 / 1
| 1
reach
"SCN10A mutations (R14L and R1268Q) cause a loss of function of Nav1.5 current, which is expected to reduce excitability and lead to the development of the arrhythmogenic substrate responsible for BrS and AF."
27761160
SCN10A binds NAV1.
| 1
SCN10A binds NAV1, bop, and SNP. 1 / 1
| 1
sparser
"The common SNP SCN10A V1073 was strongly associated with BrS and demonstrated loss of NaV1.8 function, as did rare variants in isolated patients."
25691538
SCN10A activates NAV1.
| 1
SCN10A activates NAV1. 1 / 1
| 1
reach
"Blasius A. L. et al. reported that mice carrying the Possum mutation in SCN10A, which enhances Nav1.8 channel activity and neuronal excitability, exhibit marked R-R variability upon scruffing 40."
28373696
NFkappaB affects SCN10A
| 1 2
NFkappaB binds SCN10A.
| 1 1
NFkappaB binds SCN10A. 1 / 1
| 1
reach
"NF-kappaB binding to the Scn10a (Nav1.8) promoter region increased in HbSS DRG."
29545351
NFkappaB binds SCN10A and DRG. 1 / 1
| 1
sparser
"NF-κB binding to the Scn10a (Nav1.8) promoter region increased in HbSS DRG."
29545351
NFkappaB activates SCN10A.
| 1
NFkappaB activates SCN10A. 1 / 1
| 1
reach
"To examine whether NF-kappaB activation directly regulates Scn10a transcriptional activity, we performed a dual luciferase assay using a mouse neuronal cell line (CAD cells) 34 transfected with a luciferase reporter vector containing the Scn10a gene promoter."
29545351
FGF14 affects SCN10A
2 | 1
FGF14 binds SCN10A.
1 | 1
SCN10A binds FGF14. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
Sodium_channels binds SCN10A and FGF14. 1 / 1
| 1
sparser
"The mutant FGF14 protein fails to interact with sodium channel subunits, and interferes with the interaction between wild-type FGF14 and voltage-gated sodium channel subunits in a dominant manner xref ."
19822774
FGF14 inhibits SCN10A.
1 |
FGF14 inhibits SCN10A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
Sodium atom affects SCN10A
| 2
Sodium atom binds SCN10A.
| 1
Sodium atom binds SCN10A. 1 / 1
| 1
sparser
"Voltage-gated sodium (Na V ) channels are heteromeric transmembrane proteins that consist of a single pore forming α-subunit associated with one or more auxiliary β-subunits (Na V βs) [ xref ]."
30814913
Sodium atom activates SCN10A.
| 1
Sodium atom activates SCN10A. 1 / 1
| 1
sparser
"Voltage-gated sodium channels (VGSCs) activation elongates SCO duration and reduces SCO frequency while inhibition of VGSCs decreases SCO frequency without affecting amplitude and duration."
28102360
Rsd affects SCN10A
| 2
Rsd inhibits SCN10A. 2 / 2
| 2
sparser
"Therefore, RSD inhibits RAAS and SNS simultaneously to block the neurohormonal activation in vivo , which may play a role in anti-HF effects."
27490896
sparser
"Inhibition of RAAS and SNS by RSD may represent an important mechanism in the improvement of cardiac dysfunction after MI [ xref , xref ]."
27490896
Double-stranded RNA affects SCN10A
| 2
Double-stranded RNA activates SCN10A. 2 / 2
| 2
sparser
"NK cells were treated with dsRNA-activated DC SNs with or without neutralizing Abs."
20639488
sparser
"DsRNA-activated mDC SNs generated by treating cells for 20 h were used to stimulate purified NK cells."
20639488
TNF affects SCN10A
2 |
TNF increases the amount of SCN10A.
1 |
Transcriptionally active TNF increases the amount of SCN10A. 1 / 1
1 |
signor
"TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels."
26112872
TNF activates SCN10A.
1 |
TNF activates SCN10A. 1 / 1
1 |
signor
"TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels."
26112872
Scn10a affects SCN10A
| 2
SCN10A binds Scn10a. 2 / 2
| 2
sparser
"Control samples of SnS 2 /3DG, pristine SnS 2 , and SnS 2 /MoS 2 were also assembled."
28102356
sparser
"PRE co-pigments were composed of mainly tannins which could interact with SNs proteins and honey proline."
31791723
SCN10A affects production
| 2
SCN10A inhibits production. 2 / 2
| 2
sparser
"Another explanation of this may be due to a reduced efficiency of both the SNS [ xref ] and NPY inhibiting adipocyte leptin production in AN."
24106499
sparser
"One explanation of this may be a reduced efficiency of both the SNS and NPY inhibiting adipocyte leptin production in AN."
22093818
SCN10A affects inflammatory response
| 2
SCN10A activates inflammatory response. 2 / 2
| 2
reach
"However, NGF-immunoreactivity in basal keratinocytes, and intra-epidermal PGP 9.5-positive nerve fibres, were reduced in both sites compared to non leprosy controls, as were nerve fibres positive for the sensory neurone specific sodium channel SNS and PN3, which is regulated by NGF, and may mediate inflammation induced hypersensitivity."
10692623
reach
"However, NGF-immunoreactivity in basal keratinocytes and intra-epidermal PGP 9.5-positive nerve fibers, were reduced in both sites compared to nonleprosy controls, as were nerve fibers positive for the sensory neuron specific sodium channel SNS1 and PN3, which is regulated by NGF and may mediate inflammation induced hypersensitivity."
14699981
SCN10A affects TCF4
| 2
SCN10A binds TCF4. 2 / 2
| 2
reach
"These results in both human and rat indicate TCF4 directly binds to genomic regions within KCNQ1 and SCN10a and suggests TCF4 could directly regulate the expression of these genes."
26971948
reach
"To determine if TCF4 directly binds to KCNQ1 and SCN10a we first analyzed the publicly available ENCODE datasets of TCF4 ChIP-seq performed in human K562 cell line."
26971948
SCN10A affects Sodium_channels, and bop
| 2
Sodium_channels binds SCN10A and bop. 2 / 2
| 2
sparser
"Variants in CACNA1C (Cav1.2), CACNB2b (CavB2b) and CACNA2D1 (Cavα2δ) have been reported in up to 13% of probands. [ xref – xref ] Mutations in glycerol-3-phophate dehydrogenase 1- like enzyme gene (GPD1L), SCN1B (β1-subunit of Na channel), KCNE3 (MiRP2), SCN3B (β3- subunit of Na channel), KCNJ8 (Kir6.1), KCND3 (Kv4.3), RANGRF (MOG1), SLMAP, ABCC9 (SUR2A), SNC2B (Navβ2), PKP2 (Plakophillin-2), FGF12 (FHAF1), HEY2, and SEMA3A (Semaphorin) are relatively rare.[ xref – xref ] An association of BrS with SCN10A, a neuronal sodium channel, was recently reported.[ xref , xref ]"
29757020
sparser
"An association of BrS with SCN10A , a neuronal sodium channel, was recently reported xref , xref , xref ."
27761155
SCN10A affects Scn10a
| 2
SCN10A binds Scn10a. 2 / 2
| 2
sparser
"Control samples of SnS 2 /3DG, pristine SnS 2 , and SnS 2 /MoS 2 were also assembled."
28102356
sparser
"PRE co-pigments were composed of mainly tannins which could interact with SNs proteins and honey proline."
31791723
SCN10A affects PKA
| 2
SCN10A inhibits PKA.
| 1
SCN10A inhibits PKA. 1 / 1
| 1
reach
"PN3 could inhibit PKA and CREB and the subsequent degradation of microphthalmia associated transcription factor (MITF), resulting in the suppression of melanogenic enzymes and melanin production, probably because of the presence of flavonoid compounds."
29385729
SCN10A dephosphorylates PKA.
| 1
SCN10A leads to the dephosphorylation of PKA. 1 / 1
| 1
reach
"As shown in XREF_FIG, PN3 preincubation inhibited the alpha-MSH-induced phosphorylation of PKA and CREB."
29385729
SCN10A affects PGR
| 1 1
SCN10A binds PGR.
| 1
SCN10A binds PGR. 1 / 1
| 1
sparser
"Recent genome-wide association studies revealed that a nonsynonymous single nucleotide polymorphism, rs6795970, in the SCN10A gene was associated with the PR interval."
26104176
SCN10A activates PGR.
| 1
SCN10A activates PGR. 1 / 1
| 1
reach
"Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation."
24072447
SCN10A affects NFkappaB
| 1 1
NFkappaB binds SCN10A. 1 / 1
| 1
reach
"NF-kappaB binding to the Scn10a (Nav1.8) promoter region increased in HbSS DRG."
29545351
NFkappaB binds SCN10A and DRG. 1 / 1
| 1
sparser
"NF-κB binding to the Scn10a (Nav1.8) promoter region increased in HbSS DRG."
29545351
SCN10A affects FGF14
1 | 1
SCN10A binds FGF14. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
Sodium_channels binds SCN10A and FGF14. 1 / 1
| 1
sparser
"The mutant FGF14 protein fails to interact with sodium channel subunits, and interferes with the interaction between wild-type FGF14 and voltage-gated sodium channel subunits in a dominant manner xref ."
19822774
SCN10A affects DNA Damage
| 1 1
SCN10A inhibits DNA Damage. 2 / 2
| 1 1
sparser
"This indicated that PN3 could inhibit DNA damage by Fenton’s reagent."
29385729
reach
"This indicated that PN3 could inhibit DNA damage by Fenton 's reagent."
29385729
SCN10A affects CREB
| 2
SCN10A inhibits CREB.
| 1
SCN10A inhibits CREB. 1 / 1
| 1
reach
"PN3 could inhibit PKA and CREB and the subsequent degradation of microphthalmia associated transcription factor (MITF), resulting in the suppression of melanogenic enzymes and melanin production, probably because of the presence of flavonoid compounds."
29385729
SCN10A dephosphorylates CREB.
| 1
SCN10A leads to the dephosphorylation of CREB. 1 / 1
| 1
reach
"As shown in XREF_FIG, PN3 preincubation inhibited the alpha-MSH-induced phosphorylation of PKA and CREB."
29385729
PSMD4 affects SCN10A
| 2
SCN10A binds PSMD4. 1 / 1
| 1
sparser
"Other sodium channel proteins are scarcely expressed in cardiomyocytes and have not been associated with the development of AF at this time."
26085805
Sodium_channels binds SCN10A, SCN5A, and PSMD4. 1 / 1
| 1
sparser
"SCN5A and SCN10A cardiac sodium channel related genes are associated with AF."
25054116
NEDD4L affects SCN10A
2 |
NEDD4L ubiquitinates SCN10A.
1 |
NEDD4L ubiquitinates SCN10A. 1 / 1
1 |
signor
"The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2)."
23778145
NEDD4L decreases the amount of SCN10A.
1 |
NEDD4L decreases the amount of SCN10A. 1 / 1
1 |
signor
"The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2)."
23778145
MCF2L2 affects SCN10A
| 2
MCF2L2 inhibits SCN10A. 2 / 2
| 2
reach
"After axotomy, rat DRG neurones down-regulate SNS and PN3 transcripts, but there is, nevertheless, accumulation of the sodium channels at the point of nerve injury, indicating translocation of sodium channels from the cell body to the axon [15]."
10675548
reach
"After axotomy, rat DRG neurones down-regulate SNS and PN3 transcripts, but there is, nevertheless, accumulation of the sodium channels at the point of nerve injury, indicating translocation of sodium channels from the cell body to the axon [15]."
10675548
FGF13 affects SCN10A
2 |
FGF13 inhibits SCN10A.
1 |
FGF13 inhibits SCN10A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF13 binds SCN10A.
1 |
SCN10A binds FGF13. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF12 affects SCN10A
2 |
FGF12 inhibits SCN10A.
1 |
FGF12 inhibits SCN10A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF12 binds SCN10A.
1 |
SCN10A binds FGF12. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF11 affects SCN10A
2 |
FGF11 inhibits SCN10A.
1 |
FGF11 inhibits SCN10A. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
FGF11 binds SCN10A.
1 |
SCN10A binds FGF11. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
Enh-A affects SCN10A
| 2
Enh-A activates SCN10A. 2 / 2
| 2
reach
"Through dual-luciferase reporter assays in 293T cells, we found that the SCN10A enhancer A (Enh-A) increased the activity of the SCN10A promoter (P < 0.05)."
29448912
reach
"In this study, we found that Enh-A could enhance the activity of the SCN10A promoter."
29448912
Tetrodotoxin affects SCN10A
| 1
Tetrodotoxin inhibits SCN10A. 1 / 1
| 1
reach
"The voltage gated sodium channel family is comprised of ten members : SCN1A (Nav1.1), SCN2A (Nav1.2; SCN2A1 in mouse), SCN3A (Nav1.3), SCN4A (Nav1.4), SCN8A (Nav1.6), and SCN9A (Nav1.7) are blocked by tetrodotoxin, whereas SCN5A (Nav1.5), SCN7A (Nax), SCN10A (Nav1.8), and SCN11A (Nav1.9) are not blocked by tetrodotoxin [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
19284629
Sodium(1+) affects SCN10A
| 1
Sodium(1+) inhibits SCN10A. 1 / 1
| 1
sparser
"Voltage-gated Na+ channel inactivation can be impaired by oxidative stress and endotoxins [ xref , xref ], which coincides with significant elevated pCO 2 levels in our CIP patients group compared to the ICU controls."
27207148
Rs6801957 mutant affects SCN10A
| 1
Rs6801957 mutant inhibits SCN10A. 1 / 1
| 1
reach
"Through experimental pain sensitivity measurement in healthy women, we found that the rs6801957 mutant located in Enh-A could reduce mechanical pain sensitivity (including D-PTO and S-PTO) in the participants; then, using duel-luciferase reporter assays, we found that rs6801957 mutant may inhibit the activity of the SCN10A promoter."
29448912
Rs6801957 affects SCN10A
| 1
SCN10A binds rs6801957. 1 / 1
| 1
sparser
"In addition, based on the important role of mechanical pain sensitivity in the development of chronic pain xref , xref and the importance of SCN10A in chronic pain, xref rs6801957 may also be associated with chronic pain."
29448912
Pyraclofos affects SCN10A
| 1
Pyraclofos activates SCN10A. 1 / 1
| 1
sparser
"Intheproton-dependenteffect inthedihydropyridinereceptor(41,42),thezinceffectinthe cardiac batrachotoxin-modified voltage-activated sodium channel(39,43),andthebovinepancreatictrypsininhibitor effect inthe large conductance Ca2+-activated K+ channel (44, 45) the conductance changewas representedby an al- lostericmodelinwhichthereisaconformationalequilibrium betweentheopenstateandsubstatelevels,atransitionhighly favored in the presence ofblocker."
8218909
Prkg2 affects SCN10A
| 1
Prkg2 activates SCN10A. 1 / 1
| 1
sparser
"In the dark, the ROS contains an unusally high concentration of cGMP (≈ 70 μM), which activates the sodium channel and depolarizes the membrane."
24683528
Potassium(1+) affects SCN10A
| 1
Potassium(1+) inhibits SCN10A. 1 / 1
| 1
sparser
"Voltage-gated potassium (KV) channel inhibition with either 4-aminopyridine or astemizole decreased both hemocyte recruitment and collagen deposition compared to saline infusion (P < 0.05), whereas inhibition of calcium-permeable channels with ruthenium red did not affect either response to ES Thus, macrophage-like hemocytes in P. clarkii elicit a wound-like response to exogenous ES and this is accompanied by collagen deposition."
27335435
Lithium atom affects SCN10A
| 1
Lithium atom inhibits SCN10A. 1 / 1
| 1
eidos
"The Ipato the oxidation while Ipcrefer to the reduction of SnS by Li + ions as given by Equation ( 3 ) ; For cycling stability of the prepared material , 20 cycles of cyclic voltammetry were performed at a scan rate of 100 mV / s in a potential window of -1.5 to +1.5 V."
32411656
Lipopolysaccharide affects SCN10A
| 1
Lipopolysaccharide activates SCN10A. 1 / 1
| 1
reach
"Specifically, postnatal day 3 (PN3) male Sprague-Dawley rats were induced by right intracerebral injections of doxorubicin and lipopolysaccharide."
28462453
Lectin affects SCN10A
| 1
SCN10A binds lectin. 1 / 1
| 1
sparser
"Results Binding of the solubilized sodium channel SBC to immobilized lectins The binding of the sodium channel saxitoxin- binding component (SBC) to lectins specific for each of the commonly found cell surface saccharides was examined (Table II)."
6268157
Doxorubicin affects SCN10A
| 1
Doxorubicin activates SCN10A. 1 / 1
| 1
reach
"Specifically, postnatal day 3 (PN3) male Sprague-Dawley rats were induced by right intracerebral injections of doxorubicin and lipopolysaccharide."
28462453
Cytokine affects SCN10A
| 1
Cytokine activates SCN10A. 1 / 1
| 1
sparser
"It has been long known that activation of the SNS and the HPA by proinflammatory cytokines in systemic inflammation results in the release of glucocorticoids and catecholamines, which in turn inhibit further production of proinflammatory mediators."
12939340
CGMP subfamily affects SCN10A
| 1
CGMP subfamily inhibits SCN10A. 1 / 1
| 1
sparser
"Changes in cGMP levels in the IMCD are important because cGMP can inhibit the amiloride- sensitive sodium channel in the apical membrane [3]."
9113081
Amide affects SCN10A
| 1
Amide activates SCN10A. 1 / 1
| 1
sparser
"Coscoy S, Lingueglia E, Lazdunski M, Barbry P: The FMRF amide activated sodium channel is a tetramer."
9719863
TYRP1 affects SCN10A
| 1
SCN10A binds TYRP1. 1 / 1
| 1
sparser
"Lipids, including LPA, can indirectly activate or sensitize nociceptors by interacting with TRP or sodium channel families, or by recruiting immune cells to the site of inflammation."
25695267
TBX5 affects SCN10A
| 1
TBX5 increases the amount of SCN10A. 1 / 1
| 1
reach
"In particular, the T-box transcription factor TBX3 suppresses, whereas the related factor TBX5 enhances transcription of SCN5A and SCN10A in mouse heart by interacting with conserved binding sites located within these two neighboring genes."
24721653
TBCEL affects SCN10A
| 1
TBCEL inhibits SCN10A. 1 / 1
| 1
sparser
"They induce a prolongation of the action the disulfide bridge Cys 12-Cys 63, suggesting the potential of nerves and muscles by slowing down possible location of an antigenic site in this region (El inactivation of the sodium channel (Romey et al., Ayeb et al., &3b)."
6201732
Sympathetic Nervous System affects SCN10A
| 1
SCN10A binds Sympathetic Nervous System. 1 / 1
| 1
reach
"Although mutagenesis experiments have not been reported, this hydrophilic 256 Ser seems to contribute to the low-affinity TTX binding of SNS and PN3."
9427539
SCN10A affects users receive messages send thoughts social networks
| 1
SCN10A inhibits users receive messages send thoughts social networks. 1 / 1
| 1
eidos
"In other words , SNSs allow users not only to receive messages , but also to send out their thoughts and ideas to their social networks ."
32288174
SCN10A affects shift online environment one-way communication model information is pushed passive audiences two-way model characterized participation collaboration openness
| 1
SCN10A activates shift online environment one-way communication model information is pushed passive audiences two-way model characterized participation collaboration openness. 1 / 1
| 1
eidos
"Based on the ideological and technological foundations of Web 2.0 ( Kaplan & Haenlein , 2010 ) , SNSs have contributed to a shift in the online environment , from a one-way and `` readonly '' communication model ( whereby information is `` pushed '' onto passive audiences ) to a two-way model characterized by participation , collaboration , and openness ( Eysenbach , 2008 ; Kreps & Neuhauser , 2010 ) ."
32288174
SCN10A affects rs6801957
| 1
SCN10A binds rs6801957. 1 / 1
| 1
sparser
"In addition, based on the important role of mechanical pain sensitivity in the development of chronic pain xref , xref and the importance of SCN10A in chronic pain, xref rs6801957 may also be associated with chronic pain."
29448912
SCN10A affects potassium(1+)
| 1
SCN10A activates potassium(1+). 1 / 1
| 1
sparser
"This is followed by a mechanistic focus in the articles enti- tled ‘Nonpeptidic ligands for peptide and protein receptors’ (Freidinger, pp 395-406), ‘Interfering with chemokine net- works -the hope for new therapeutics’ (Schwartz and Wells, pp 407-417), ‘Cannabinoids, endogenous ligands and synthetic analogs’ (Pop, pp 41&425), ‘Muscarinic receptor ligands and their therapeutic potential’ (Eglen et al: pp 4X-432), ‘Metabotropic G-protein-coupled glutamate receptors as therapeutic targets’ and ‘Ionotropic glutamate receptors’ (Pellicciari and Costantino, pp 433-440; Bigge, pp 441-447), ‘Pharmacology of voltage-gated and calcium- activated potassium channels’ (Kaczorowski and Garcia, pp 448-4.58), ‘The development and therapeutic potential of protein kinase inhibitors’ (Cohen, pp 459-465) and ‘Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents’ (Doherty, pp 46w73)."
10419859
SCN10A affects oxidative phosphorylation
| 1
SCN10A inhibits oxidative phosphorylation. 1 / 1
| 1
reach
"Thus it seems very probable that DNP and NaNg block the cortical change through a common mechanism, i.e., uncoupling of oxidative phosphorylation."
13317913
SCN10A affects nationwide panic
| 1
SCN10A activates nationwide panic. 1 / 1
| 1
eidos
"SNSs facilitate false information to be spread due to their fastforwarding characteristic ( Adachi and Toda , 2015 ; Zhang and Leung , 2014 ) , and consequently creates nationwide panic ( Tanaka et al ., 2012 ) ."
| PMC
SCN10A affects marked capsid protein
| 1
SCN10A inhibits marked capsid protein. 1 / 1
| 1
eidos
"PPMO HP1 , HP2 , HP3U and HPN3 produced marked reduction of capsid protein expression , indicating inhibition of HEV replication , while CP1 had minimal effect ( Fig. 3B ) ."
26086884
SCN10A affects majority % inward
| 1
SCN10A inhibits majority % inward. 1 / 1
| 1
eidos
"On the other hand , Nav1.9 does not contribute much to the amplitude of APs44 , suggesting that enhancing Nav1.9 activity is unable to compensate for the loss of Nav1.8 , which contributes to the majority ( 58-90 % ) of the inward current during the rising phase of an all-or-none AP in nociceptive sensory neurons19 ,47,53 ."
32385249
SCN10A affects lectin
| 1
SCN10A binds lectin. 1 / 1
| 1
sparser
"Results Binding of the solubilized sodium channel SBC to immobilized lectins The binding of the sodium channel saxitoxin- binding component (SBC) to lectins specific for each of the commonly found cell surface saccharides was examined (Table II)."
6268157
SCN10A affects glutathione
| 1
SCN10A inhibits glutathione. 1 / 1
| 1
reach
"Consequently, PN3 inhibited arachidonic acid (AA) + iron induced reactive oxygen species generation and glutathione depletion, and, thus, highlighted their role in cytotoxicity."
30626086
SCN10A affects generation
| 1
SCN10A inhibits generation. 1 / 1
| 1
sparser
"Consequently, PN3 inhibited arachidonic acid (AA) + iron-induced reactive oxygen species generation and glutathione depletion, and, thus, highlighted their role in cytotoxicity."
30626086
SCN10A affects dose-dependent luciferase
| 1
SCN10A inhibits dose-dependent luciferase. 1 / 1
| 1
eidos
"Further evaluations showed that PPMO HP1 , HPN3 and HP3U generated dose-dependent reductions of luciferase expression ( Fig. 4B ) ."
26086884
SCN10A affects cell population proliferation
| 1
SCN10A inhibits cell population proliferation. 1 / 1
| 1
sparser
"Acid-treated axolotl PHA-SNs also inhibited proliferation of PHA-stimulated freshly harvested axolotl spleen cells."
9617586
SCN10A affects cGMP
| 1
SCN10A activates cGMP. 1 / 1
| 1
reach
"We found that cGMP accumulation in guinea pig peritoneal macrophages can be induced by both universal stimulants, such as nitroprusside, and by NaNg and NHzOH, which require the catalase like activator."
6248250
SCN10A affects binding
| 1
SCN10A inhibits binding. 1 / 1
| 1
sparser
"In addition, the H2A modulator can still drive expression of a divergently oriented transcription unit, suggesting that sns does not inhibit binding of transcription factor(s) to the enhancer."
11124024
SCN10A affects alpha-gliadin
| 1
SCN10A activates alpha-gliadin. 1 / 1
| 1
reach
"The PN3 mAb [XREF_BIBR] was raised against a synthetic peptide equivalent to the amino acids 31-49 (LGQQQPFPPQQPYPQPQPF) of alpha-gliadin, which has been shown to cause mucosal damage to the small bowel of coeliac patients, both in vivo and in vitro [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
22253984
SCN10A affects TYRP1
| 1
SCN10A binds TYRP1. 1 / 1
| 1
sparser
"Lipids, including LPA, can indirectly activate or sensitize nociceptors by interacting with TRP or sodium channel families, or by recruiting immune cells to the site of inflammation."
25695267
SCN10A affects TYR
| 1
SCN10A decreases the amount of TYR. 1 / 1
| 1
reach
"In this study, PN3 downregulated the expression of tyrosinase, TRP 1, TRP 2, and MITF."
29385729
SCN10A affects TTX-R
| 1
SCN10A activates TTX-R. 1 / 1
| 1
reach
"Application of the selective SCN10A blocker, A-803467 32 blocked> 90% of the TTX-R currents (XREF_FIG) in all cases."
22750882
SCN10A affects Sympathetic Nervous System
| 1
SCN10A binds Sympathetic Nervous System. 1 / 1
| 1
reach
"Although mutagenesis experiments have not been reported, this hydrophilic 256 Ser seems to contribute to the low-affinity TTX binding of SNS and PN3."
9427539
SCN10A affects SCLT1
1 |
SCN10A binds SCLT1. 1 / 1
1 |
hprd
No evidence text available
15797711
SCN10A affects Reactive Oxygen Species
| 1
SCN10A inhibits Reactive Oxygen Species. 1 / 1
| 1
reach
"Additionally, alpha-melanocyte-stimulating hormone (alpha-MSH) induced reactive oxygen species (ROS) generation in B16F10 cells using a sensitive fluorescent assay method with dichloro-dihydro-fluorescein diacetate (DCFH-DA), whereas the PN3 pretreatment significantly prevented ROS generation by alpha-MSH (XREF_FIG B)."
29385729
SCN10A affects RELA
| 1
SCN10A binds RELA. 1 / 1
| 1
sparser
"Using ChIP analyses, a fragment within the Scn10a promoter was amplified from a complex immunoprecipitated with an anti-p65 antibody ( xref ), indicating the binding of p65 to the Scn10a gene promoter in the DRG."
29545351
SCN10A affects PPP1R10
| 1
SCN10A inhibits PPP1R10. 1 / 1
| 1
reach
"Simultaneous expression of human macrophage SCN5A and SCN10A was required to decrease expression of the retained intron and increase protein expression of PPP1R10."
30391100
SCN10A affects Outlook 2
| 1
SCN10A activates Outlook 2. 1 / 1
| 1
reach
"The ability of mutant neuronal sodium channels to cause a loss of cardiac sodium channel activity provides insights into mechanisms by which SCN10A variants may contribute to overlap syndromes including BrS, ERS, cardiac conduction disease, and various bradycardia phenotypes Translational Outlook 2."
24998131
SCN10A affects N-acetyl-beta-neuraminic acid
| 1
SCN10A activates N-acetyl-beta-neuraminic acid. 1 / 1
| 1
reach
"Two TTX resistant sodium channels, SNS and NaN, are preferentially expressed in c-type dorsal root ganglion (DRG) neurons and have been shown recently to have distinct electrophysiological signatures, SNS producing a slowly inactivating and NaN producing a persistent sodium current with a relatively hyperpolarized voltage-dependence."
11007885
SCN10A affects Multiple Sclerosis
| 1
SCN10A activates Multiple Sclerosis. 1 / 1
| 1
reach
"In addition, sensory neuron specific SCN10A mRNA and Na v 1.8 protein are upregulated in cerebellar Purkinje neurons in both a rat demyelinating model and human MS."
18940784
SCN10A affects Melanin
| 1
SCN10A inhibits Melanin. 1 / 1
| 1
reach
"Catethins, the main components of PN3, have been proven to inhibit melanin synthesis by downregulating the expression of tyrosinase in B16 melanoma cells [XREF_BIBR]."
29385729
SCN10A affects MCF2L2
| 1
SCN10A activates MCF2L2. 1 / 1
| 1
reach
"Using ChIP analyses, a fragment within the Scn10a promoter was amplified from a complex immunoprecipitated with an anti-p65 antibody (XREF_FIG), indicating the binding of p65 to the Scn10a gene promoter in the DRG."
29545351
SCN10A affects IgG
| 1
SCN10A binds IgG. 1 / 1
| 1
sparser
"Even if the preceding specu lation is false, Appel's view (4) of the role of intra cellular calcium ions in neuronal degeneration and of the role of the interaction of ALS IgG with voltage gated calcium channels would imply that autoimmune disorders might account for most cases of nonfamilial ALS."
7523840
SCN10A affects ITS rRNA regions
| 1
SCN10A activates ITS rRNA regions. 1 / 1
| 1
reach
"Primers PN3 (5 '-CCG TTG GTG AAC CAG CGG AGG GAT C-3 ') and PN34 (5 '-TCC GCT TAT TGA TAT GCT TAA G-3 ') were used for PCR amplification of the fungal targeting ITS rRNA regions according to the conditions described by Viaud et al.."
26738601
SCN10A affects Heat Shock Protein
| 1
SCN10A binds Heat Shock Protein. 1 / 1
| 1
sparser
"Voltage-gated calcium channels gate forms of HSP."
24592212
SCN10A affects Heart Rate
| 1
SCN10A inhibits Heart Rate. 1 / 1
| 1
reach
"(5) Scn10a upregulation may contribute to lower HR, as mice expressing a hypermorphic Na v 1.8 mutant exhibit reduced HR XREF_BIBR."
27667030
SCN10A affects FGFR3
| 1
SCN10A binds FGFR3. 1 / 1
| 1
sparser
"References Nicotinic ACh Voltage-gated receptors calcium channels Blockade myasthenia gravis Lambert-Eaton syndrome Proliferation one form of ALS one form of PN What is the justification for associating ALS with proliferation of nicotinic ACh receptors?"
7523840
SCN10A affects FGF13
1 |
SCN10A binds FGF13. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN10A affects FGF12
1 |
SCN10A binds FGF12. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN10A affects FGF11
1 |
SCN10A binds FGF11. 1 / 1
1 |
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
SCN10A affects Ehlers-Danlos
| 1
SCN10A activates Ehlers-Danlos. 1 / 1
| 1
reach
"Both of these conditions are autosomal dominant with Brugada syndrome caused by mutations in cardiacsodium channel (SCN5A) and SCN10A encoding subunits of the cardiac sodium channel (gene locus 3p21-24) and Ehlers-Danlos vascular subtype being caused by heterozygous mutations in the collagen type III alpha 1 chain (COL3A1) gene (gene locus 2q31) encoding type III collagen [XREF_BIBR, XREF_BIBR]."
28536668
SCN10A affects ERs
| 1
SCN10A binds ERs. 1 / 1
| 1
sparser
"Consistent with the findings that I K-ATP activation can generate an ER pattern in canine ventricular wedge preparations, mutations in KCNJ8 and ABCC9 , responsible for the pore forming and ATP-sensing subunits of the I K-ATP channel, has been reported in a patients with ERS as well. xref , xref , xref Loss of function mutations in the α1, α2 and α2δ subunits of the cardiac L-type calcium channel ( CACNA1C, CACNB2, and CACNA2D1 ) have been uncovered in patients with ERS xref as have mutations in SCN5A . xref We have also recently reported an association of SCN10A with ERS. xref "
25869754
SCN10A affects ERVK-18
| 1
SCN10A binds ERVK-18. 1 / 1
| 1
sparser
"Permethrin binding to the neuronal-specific transmembrane protein, Vgsc, could result in synaptic injury."
30695054
SCN10A affects EGFP
| 1
SCN10A increases the amount of EGFP. 1 / 1
| 1
reach
"A 3.7 kb fragment of the mouse Scn10a gene promoter directs neural crest but not placodal lineage EGFP expression in a transgenic animal."
25995484
SCN10A affects BRM
| 1
SCN10A increases the amount of BRM. 1 / 1
| 1
reach
"We recently reported a characterization of the expression pattern of ChR2-eYFP in sensory neurons in the same mouse lines used here to generate ChR2 expression driven by the Scn10a Cre and Trpv1 Cre mice."
29483864
SCN10A affects Awareness
| 1
SCN10A activates Awareness. 1 / 1
| 1
eidos
"Given that SNSs have been recognized as useful communication tools to raise awareness during an infectious disease outbreak ( Chew & Eysenbach , 2010 ; Ding & Zhang , 2010 ; Liu & Kim , 2011 ) , it is reasonable to assume that communication via SNSs of diseaserelated information influences people 's perceptions , concerns , and behaviors in relation to the outbreak ."
32288174
SCN10A affects Action potential
1 |
SCN10A activates Action potential. 1 / 1
1 |
signor
"The expression of voltage-gated sodium channels (NaVs) is a key feature for initiation and conduction of action potentials in excitable tissues and cells such as cardiac and skeletal muscle and neurons."
26043074
SCN10A affects ACTB
1 |
SCN10A binds ACTB. 1 / 1
1 |
hprd
No evidence text available
12591166
SCN10A affects (-)-epicatechin-3-O-gallate
| 1
SCN10A inhibits (-)-epicatechin-3-O-gallate. 1 / 1
| 1
reach
"While others have reported that A803467 or Scn10a knockout1, 2 produces ECG changes in intact mice, we found no such differences."
27806966
SCLT1 affects SCN10A
1 |
SCN10A binds SCLT1. 1 / 1
1 |
hprd
No evidence text available
15797711
REST affects SCN10A
| 1
REST inhibits SCN10A. 1 / 1
| 1
reach
"Knock-down of NRSF with antisense oligonucleotides prevented the downregulation of Oprm1 and Scn10a (gene encoding Nav1.8 channels), further supporting the hypothesis that NRSF mediated mechanisms are responsible for injury induced transcriptional suppression of Oprm1 and Scn10a genes in the DRG [XREF_BIBR]."
25765319
RELA affects SCN10A
| 1
SCN10A binds RELA. 1 / 1
| 1
sparser
"Using ChIP analyses, a fragment within the Scn10a promoter was amplified from a complex immunoprecipitated with an anti-p65 antibody ( xref ), indicating the binding of p65 to the Scn10a gene promoter in the DRG."
29545351
PSMD4 affects SCN10A, SCN5A, and Sodium_channels
| 1
Sodium_channels binds SCN10A, SCN5A, and PSMD4. 1 / 1
| 1
sparser
"SCN5A and SCN10A cardiac sodium channel related genes are associated with AF."
25054116
PRKCD affects SCN10A
| 1
PRKCD activates SCN10A. 1 / 1
| 1
reach
"Phosphorylation of Nrf2 in HepG2 cells was enhanced in PN3, which was mediated by PKCdelta, ERK, and p38 MAPK."
30626086
PGR affects SCN10A
| 1
SCN10A binds PGR. 1 / 1
| 1
sparser
"Recent genome-wide association studies revealed that a nonsynonymous single nucleotide polymorphism, rs6795970, in the SCN10A gene was associated with the PR interval."
26104176
NAV1 affects SCN10A, SNP, and bop
| 1
SCN10A binds NAV1, bop, and SNP. 1 / 1
| 1
sparser
"The common SNP SCN10A V1073 was strongly associated with BrS and demonstrated loss of NaV1.8 function, as did rare variants in isolated patients."
25691538
N-acetyl-beta-neuraminic acid affects SCN10A
| 1
N-acetyl-beta-neuraminic acid inhibits SCN10A. 1 / 1
| 1
reach
"In brachial plexus injury patients, there was an acute decrease of SNS and PN3- and NaN and SNS2 like immunoreactivity in sensory cell bodies of cervical dorsal root ganglia (DRG) whose central axons had been avulsed from spinal cord, with gradual return of the immunoreactivity to control levels over months."
10692601
Melanin affects SCN10A
| 1
Melanin inhibits SCN10A. 1 / 1
| 1
reach
"PN3 Downregulated Melanin Synthesis Genes."
29385729
KNG1 affects SCN10A
| 1
KNG1 activates SCN10A. 1 / 1
| 1
reach
"The membrane fractions of PKCalpha and PKCgamma increased in PC10 and PN3 cells when treated with bradykinin."
12592377
IgG affects SCN10A
| 1
SCN10A binds IgG. 1 / 1
| 1
sparser
"Even if the preceding specu lation is false, Appel's view (4) of the role of intra cellular calcium ions in neuronal degeneration and of the role of the interaction of ALS IgG with voltage gated calcium channels would imply that autoimmune disorders might account for most cases of nonfamilial ALS."
7523840
IL10 affects SCN10A
1 |
Transcriptionally active IL10 decreases the amount of SCN10A. 1 / 1
1 |
signor
"Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α."
23357618
Heat Shock Protein affects SCN10A
| 1
SCN10A binds Heat Shock Protein. 1 / 1
| 1
sparser
"Voltage-gated calcium channels gate forms of HSP."
24592212
GDNF affects SCN10A
| 1
GDNF activates SCN10A. 1 / 1
| 1
reach
"As shown above, the effects of neurotrophins on sodium channel expression in DRG neurons appear to be specific (up-regulation of SNS and PN3, together with down-regulation of a-III by NGF; up-regulation of NaN by GDNF)."
11098678
FGFR3 affects SCN10A
| 1
SCN10A binds FGFR3. 1 / 1
| 1
sparser
"References Nicotinic ACh Voltage-gated receptors calcium channels Blockade myasthenia gravis Lambert-Eaton syndrome Proliferation one form of ALS one form of PN What is the justification for associating ALS with proliferation of nicotinic ACh receptors?"
7523840
FGF14 affects SCN10A, and Sodium_channels
| 1
Sodium_channels binds SCN10A and FGF14. 1 / 1
| 1
sparser
"The mutant FGF14 protein fails to interact with sodium channel subunits, and interferes with the interaction between wild-type FGF14 and voltage-gated sodium channel subunits in a dominant manner xref ."
19822774
ESR2 affects SCN10A
1 |
Transcriptionally active ESR2 decreases the amount of SCN10A. 1 / 1
1 |
signor
"17β-Estradiol regulates the gene expression of voltage-gated sodium channels. . In this study, we investigate the mRNA expressions of Nav channel subtypes mediated differentially by the ERs in the DRGs of wild-type (WT) and estrogen receptor knockout (αERKO and βERKO) mice. In the present study, by means of quantitative real-time PCR, we found that the expressions of Nav1.1, Nav1.7, Nav1.8, and Nav1.9 subtypes were elevated in αERKO and βERKO mice"
22169964
ESR1 affects SCN10A
1 |
Transcriptionally active ESR1 decreases the amount of SCN10A. 1 / 1
1 |
signor
"17β-Estradiol regulates the gene expression of voltage-gated sodium channels. . In this study, we investigate the mRNA expressions of Nav channel subtypes mediated differentially by the ERs in the DRGs of wild-type (WT) and estrogen receptor knockout (αERKO and βERKO) mice. In the present study, by means of quantitative real-time PCR, we found that the expressions of Nav1.1, Nav1.7, Nav1.8, and Nav1.9 subtypes were elevated in αERKO and βERKO mice"
22169964
ERs affects SCN10A
| 1
SCN10A binds ERs. 1 / 1
| 1
sparser
"Consistent with the findings that I K-ATP activation can generate an ER pattern in canine ventricular wedge preparations, mutations in KCNJ8 and ABCC9 , responsible for the pore forming and ATP-sensing subunits of the I K-ATP channel, has been reported in a patients with ERS as well. xref , xref , xref Loss of function mutations in the α1, α2 and α2δ subunits of the cardiac L-type calcium channel ( CACNA1C, CACNB2, and CACNA2D1 ) have been uncovered in patients with ERS xref as have mutations in SCN5A . xref We have also recently reported an association of SCN10A with ERS. xref "
25869754
ERVK-18 affects SCN10A
| 1
SCN10A binds ERVK-18. 1 / 1
| 1
sparser
"Permethrin binding to the neuronal-specific transmembrane protein, Vgsc, could result in synaptic injury."
30695054
ERK affects SCN10A
| 1
ERK activates SCN10A. 1 / 1
| 1
reach
"Phosphorylation of Nrf2 in HepG2 cells was enhanced in PN3, which was mediated by PKCdelta, ERK, and p38 MAPK."
30626086
EIF4B2 affects SCN10A
| 1
EIF4B2 inhibits SCN10A. 1 / 1
| 1
reach
"Once currents were equilibrated in the La 3+ -containing solution, subsequent superfusion of amiloride in the continued presence of La 3+ produced no further block of SNS and Nav1.8 current at 1 mM and ~ 20% block at 3 mM."
17190903
DRG affects NFkappaB, and SCN10A
| 1
NFkappaB binds SCN10A and DRG. 1 / 1
| 1
sparser
"NF-κB binding to the Scn10a (Nav1.8) promoter region increased in HbSS DRG."
29545351
BHLHE22 affects NEUROD1, NRCAM, and SCN10A
| 1
SCN10A binds BHLHE22, NEUROD1, and NRCAM. 1 / 1
| 1
sparser
"In this study, we characterized beta1 interactions with contactin and Nf186 in greater detail and investigated interactions of beta1 with NrCAM, Nf155, and sodium channel beta2 and beta3 subunits."
15466474
B4GALNT1 affects SCN10A
| 1
B4GALNT1 activates SCN10A. 1 / 1
| 1
reach
"In retina [Fig. 4 (B)], on the other hand, GalNAc-T activity increased steadily from PN0 to PN3, more rapidly between PN3 and PN4, decreased suddenly thereafter and stabilized on relatively low values after PN6.To study the expression of the GalNac-T mRNA in rat retina cells, retinas from PN4 were dissociated, cultured for 3 days and examined by in situ hybridization."
9185159
App affects PDLIM5, and SCN10A
| 1
SCN10A binds PDLIM5 and App. 1 / 1
| 1
sparser
"This suggested that the interaction of wild-type Enh-A-G(G) with the SCN10A promoter was counteracted by mutant type Enh-A(A)."
29448912
ANK2 affects CACNA1C, CTNNA3, PKP2, SCN10A, and USP9X
| 1
SCN10A binds USP9X, CACNA1C, CTNNA3, ANK2, and PKP2. 1 / 1
| 1
sparser
"To our knowledge, this is the first report of association of the CACNA1C, CTNNA3, PKP2, ANK2 and SCN10A genes with FAF; it is also the first study in Russian families."
31539150
ANK1 affects SCN10A, and alpha-Spec
| 1
SCN10A binds ANK1 and alpha-Spec. 1 / 1
| 1
sparser
"Srinivasan, Y., L. Elmer, J. Davis, V. Bennet and K. Angelides, 1988, Ankyrin and spectrin associate with voltage-dependent sodium channel in brain, Nature 333, 177."
8566145
ACTB affects SCN10A
1 |
SCN10A binds ACTB. 1 / 1
1 |
hprd
No evidence text available
12591166