"We further found that Sp1 bound to the KCNS3 promoter and showed that inhibition of Sp1 by mithramycin A decreased K V 9.3 expression, supporting a role for Sp1 in regulating the expression of the KCNS3 gene."
"In line with the previous studies, our findings expand on these previous works by showing K V 9.3 inhibits cancer cell proliferation in vitro and in vivo."
"Taken together, these data suggest that knockdown of K V 9.3 inhibits proliferation in colon carcinoma and lung adenocarcinoma cell lines and may be regulated by Sp1."
"We further found that Sp1 bound to the KCNS3 promoter and showed that inhibition of Sp1 by mithramycin A decreased K V 9.3 expression, supporting a role for Sp1 in regulating the expression of the KCNS3 gene."
"In HCT15 cells, 100 and 250 nM mithramycin A decreased K V 9.3 expression by 0.43-fold and 0.24-fold relative to that in controls, respectively, whereas in A549 cells, the corresponding values were 0.24-fold and 0.16-fold (n = 4, two independent experiments)."
"The water channel AQP1 and the main calcium regulated ion channel in chondrocytes TRPV4 are strongly increased in Group B. XREF_BIBR Also increased in Group B are other calcium activated potassium channels including KCNN3, 4, XREF_BIBR the voltage sensitive calcium activated chloride channel ANO1 and potassium channels KCNQ5, KCNS3 and KCTD12, KCNMB4 (XREF_TABLE)."
"Consequently, the deficient expression KCNS3 and KCNB1 mRNAs in PV neurons, if reflected in a lower complement of Kv2.1/Kv9.3 channels, would be predicted to slow the time course of EPSPs in PV neurons, impairing their ability to appropriately generate gamma oscillations, and thus contribute to cognitive dysfunction in schizophrenia [XREF_BIBR]."
"Although the number of PV neurons does not appear to be altered in the disease XREF_BIBR, XREF_BIBR, they contain lower mRNA 9 and protein levels XREF_BIBR, XREF_BIBR for PV, the GABA synthesizing enzyme GAD1 12, and the potassium channel KCNS3 13."
"05) for 55 and 4 genes in the hippocampus and prefrontal cortex of dataset IV, respectively, for 22 genes in the parietal cortex (dataset V) and 5 genes in the prefrontal cortex of dataset VI. xref shows the overlap between the identified gene sets and highlights the shared schizophrenia association of the potassium channel genes KCNK1 and KCNS3 across the hippocampus, the prefrontal and the parietal cortex."