INDRA statements for KCNS1

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
Pyraclofos affects KCNS1
| 1
Pyraclofos activates KCNS1. 1 / 1
| 1
sparser
"K + transport is mediated by delayed-rectifier voltage-activated channels ( xref ), and Na + -K + ATPases ( xref ; xref )."
| PMC
Ion channel affects KCNS1
| 1
KCNS1 binds ion channel. 1 / 1
| 1
sparser
"In addition, preclinical studies have found that ALK-TKIs could inhibit the ion channel which might be associated with delayed-rectifier K+ current in the heart."
28915678
Nodal affects KCNS1
| 1
KCNS1 binds Nodal. 1 / 1
| 1
sparser
"It would therefore be informative to examine nodal assembly of Kcns1 and whether it is affected by nerve lesions in future studies."
29697531
KCNS1 affects ion channel
| 1
KCNS1 binds ion channel. 1 / 1
| 1
sparser
"In addition, preclinical studies have found that ALK-TKIs could inhibit the ion channel which might be associated with delayed-rectifier K+ current in the heart."
28915678
KCNS1 affects Nodal
| 1
KCNS1 binds Nodal. 1 / 1
| 1
sparser
"It would therefore be informative to examine nodal assembly of Kcns1 and whether it is affected by nerve lesions in future studies."
29697531
KCNS1 affects ERBB2
| 1
KCNS1 activates ERBB2. 1 / 1
| 1
reach
"Our genomic randomization prediction coupled with experimental evidence suggests that BST1, PFDN5, KCNS1 and GAL3ST4 are novel downstream targets of ERBB2 and hence the EGF signalling pathway."
23737949
HSF4 affects KCNS1, PRIMA1, and cpgS
| 1
PRIMA1 binds HSF4, KCNS1, and cpgS. 1 / 1
| 1
sparser
"These three CpGs were associated with the genes Proline rich membrane anchor 1 ( Prima1: chr12:103214639; R 2  = 0.71), Heat shock transcription factor 4 ( Hsf4: chr8:105271000; R 2  = 0.95) and Potassium voltage-gated channel modifier subfamily S member 1 ( Kcns1: chr2:164168110; R 2  = 0.83; xref ; xref )."
30142075
BMP2 affects KCNS1
| 1 1
BMP2 increases the amount of KCNS1. 1 / 1
| 1 1
reach
"BMP-2 (100 nM for 18-24 h) significantly (> 2-fold) upregulated mRNA expression of KCNA5, KCNA7, KCNA10, KCNC3, KCNC4, KCNF1, KCNG3, KCNS1, and KCNS3 but downregulated (at least 2-fold) KCNAB1, KCNA2, KCNG2, and KCNV2."
16815889
4-aminopyridine affects KCNS1
| 1
4-aminopyridine inhibits KCNS1. 1 / 1
| 1
sparser
"4-AP inhibits delayed-rectifier channels, including K v 1.1 and K v 1.2 which have been shown to be highly expressed in cold-insensitive neurons and contribute to lack of cold-sensitivity in trigeminal neurons [ xref ; xref ; xref ]."
23711479