INDRA statements for KCNQ5

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
E2 affects KCNQ5
| 10
E2 increases the amount of KCNQ5.
| 8
E2 increases the amount of KCNQ5. 8 / 8
| 8
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"As found in NPY neurons, E2 replacement significantly increased the mRNA expression of KCNQ5 in RNA extracted from the arcuate nucleus dissected from wild-type females but failed to alter KCNQ5 expression in ERalpha KO females (XREF_FIG)."
21849543
reach
"Because E2 regulates KCNQ5 and NPY gene expression in the arcuate but fails to increase KCNQ5 expression in NPY neurons in ERalpha KO mice, we determined the expression of ERalpha and ERbeta in single and pooled NPY neurons collected from ovariectomized females."
21849543
reach
"We have previously shown that E2 will increase KCNQ5 expression in the guinea pig arcuate nucleus both after 24 hr and long-term treatment using unbiased microarray analysis followed by quantitative real-time PCR."
21849543
reach
"Because E2 increased the expression of KCNQ5 in NPY neurons, we wanted to determine if this was dependent on ERalpha."
21849543
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"E2 treatment increases the mRNA expression of the KCNQ5 channel subunit that underlies the M-current and the inwardly rectifying K + (Kir) channel Kir2.4 subunit."
19187465
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"Previously, we have shown that E2 (24 hr and long-term) increases the expression of KCNQ5 in guinea pig arcuate nucleus."
21849543
reach
"In the mouse, E2 replacement also increased the expression of KCNQ5 both in the whole arcuate and specifically in NPY neurons."
21849543
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"E2 treatment increased the expression of the KCNQ5 subunit in females but not KCNQ2 or KCNQ3 subunits."
21849543
E2 decreases the amount of KCNQ5.
| 1
E2 decreases the amount of KCNQ5. 1 / 1
| 1
reach
"Because E2 suppresses food intake and NPY neurons are orexigenic, we hypothesized that E2 may suppress feeding behavior by increasing the KCNQ5 expression and activity of the M-current in NPY neurons."
21849543
E2 activates KCNQ5.
| 1
E2 activates KCNQ5. 1 / 1
| 1
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"The expression of KCNQ2 and KCNQ3 was not affected by E2 treatment while KCNQ5 was significantly increased by E2 treatment (XREF_FIG; n = 5, p < 0.05)."
21849543
Gamma-aminobutyric acid affects KCNQ5
| 6
Gamma-aminobutyric acid inhibits KCNQ5. 4 / 4
| 4
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"We recently discovered that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
31925247
reach
"We recently discovered that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
31701029
reach
"We recently discovered that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
31925247
reach
"We recently discovered that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
31701029
Gamma-aminobutyric acid activates KCNQ5. 2 / 2
| 2
reach
"Here, phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid (GABA), which directly activates KCNQ5 and KCNQ3 via W265."
29748663
reach
"Here, phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid (GABA), which directly activates KCNQ5 and KCNQ3 via W265."
29748663
CTCF affects KCNQ5
| 5
CTCF activates KCNQ5.
| 4
CTCF activates KCNQ5. 4 / 4
| 4
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"CTCF Mediates the Cell-Type Specific Spatial Organization of the Kcnq5 Locus and the Local Gene Regulation."
22347474
reach
"By comparing the CTCF binding ability with the interaction frequencies of the kcnq5 locus mediated by CTCF in the different cell lines, we found that the cell-type specific distribution of CTCF binding sites in the kcnq5 locus determined the CTCF mediated cell-type specific organization of the locus."
22347474
reach
"Here, we characterized the CTCF mediated dynamic spatial organization of the kcnq5 gene locus in detail to present a perspective of cell type specific intra-chromosomal interaction networks that are established and maintained by both cis-elements and trans-factors."
22347474
reach
"Correction : CTCF Mediates the Cell-Type Specific Spatial Organization of the Kcnq5 Locus and the Local Gene Regulation."
| PMC
CTCF increases the amount of KCNQ5.
| 1
CTCF increases the amount of KCNQ5. 1 / 1
| 1
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"In addition, it has been reported that CTCF is involved in the spatial organization of the KCNQ5 locus, and knockdown of CTCF downregulates KCNQ5 expression 46."
29670109
CALM affects KCNQ5
| 2 3
CALM binds KCNQ5.
| 2 1
CALM binds KCNQ5. 3 / 3
| 2 1
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"The maximal level of KCNQ5 and CaM interaction was found when photoreceptors had almost completely disappeared; the KCNQ5 and VGluT1 interaction signal decreased and the KCNQ5 and GFAP interaction increased in the inner retina, while degeneration progressed."
25499209
sparser
"Retinal degeneration progression in P23H-1 rats can be followed by an interaction between KCNQ5 with CaM in an in situ system."
25499209
sparser
"The physical interactions of KCNQ5 with calmodulin (CaM), vesicular glutamate transporter 1 (VGluT1) and glial fibrillary acidic protein (GFAP) were analyzed by in situ proximity ligation assays and were supported by calcium recording."
25499209
CALM inhibits KCNQ5.
| 2
CALM inhibits KCNQ5. 2 / 2
| 2
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"Moreover, overexpression of CaM reduced current amplitudes of KCNQ2, KCNQ4, and KCNQ5, but not those of KCNQ1 and KCNQ3."
23087646
reach
"Coexpression of CaM in Chinese hamster ovary (CHO) cells strongly reduced currents of KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3."
15901836
Ezogabine affects KCNQ5
| 4
Ezogabine activates KCNQ5. 4 / 4
| 4
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"Moreover, KCNQ3 and KCNQ5 channels are potently activated by the anticonvulsant retigabine (Wickenden et al., 2001)."
12890507
reach
"In the present study, retigabine enhanced the KCNQ5 current at -30 and -60 mV, by 3 and 7 fold, respectively."
11890900
reach
"Retigabine activated the KCNQ5 channel by increasing the current in a concentration dependent way."
11890900
reach
"Recently, Wickenden et al. (2001) have also shown that retigabine can activate the KCNQ5 and KCNQ3 heteromer expressed in CHO cells."
11890900
PKC affects KCNQ5
| 4
PKC inhibits KCNQ5. 4 / 4
| 4
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"These results suggest that despite its ability to directly activate TRPC6 channels (XREF_SUPPLEMENTARY), DAG contributes to the stimulation of Ca 2+ spiking primarily via PKC dependent suppression of KCNQ5 currents."
19246091
reach
"We previously provided evidence that physiological concentrations (10-100 pM) of AVP indeed produce membrane depolarization and Ca 2+ influx in A7r5 rat aortic smooth muscle cells through a protein kinase C (PKC)-dependent suppression of KCNQ5 currents [XREF_BIBR]."
19246091
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"These results suggest that the stimulation of Ca (2+) spiking by physiological concentrations of AVP involves PKC dependent inhibition of KCNQ5 channels and increased AP firing in A7r5 cells."
17071736
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"We previously provided evidence that physiological concentrations (10-100 pM) of AVP indeed produce membrane depolarization and Ca 2+ influx in A7r5 rat aortic smooth muscle cells through a protein kinase C (PKC)-dependent suppression of KCNQ5 currents [XREF_BIBR]."
19246091
KCNQ5 affects calcium(2+)
| 4
KCNQ5 inhibits calcium(2+).
| 2
KCNQ5 inhibits calcium(2+). 2 / 2
| 2
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"The resulting outward K + current opposes membrane depolarization and prevents E m from reaching the threshold for triggering action potential firing; (2) Suppression of KCNQ5 channel activity by physiological concentrations of AVP will depolarize the membrane and stimulate Ca 2+ influx though voltage sensitive Ca 2+ channels; (3) Activation of TRPC6 non selective cation currents modestly contributes to AVP induced membrane depolarization and generation of Ca 2+ spikes at physiological concentrations of AVP."
19246091
reach
"KCNQ5 knockdown resulted in more positive resting membrane potentials and induced spontaneous action potential firing and Ca 2+ spiking."
19246091
KCNQ5 activates calcium(2+).
| 2
KCNQ5 activates calcium(2+). 2 / 2
| 2
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"Similarly, KCNQ4 and KCNQ5 are key modulators of L-type Ca 2+ channel activity in cardiovascular cells [XREF_BIBR]."
24555524
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"Here we examine the relative contributions of KCNQ5 channels and TRPC6 non selective cation channels to AVP stimulated Ca 2+ spiking using patch clamp electrophysiology and fura-2 fluorescence measurements in A7r5 cells."
19246091
Hsa-miR-6867-5p affects KCNQ5
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Transcriptionally active hsa-miR-6867-5p decreases the amount of KCNQ5. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-574-5p affects KCNQ5
3 |
Transcriptionally active hsa-miR-574-5p decreases the amount of KCNQ5. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23824327
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
SLC6A1 affects KCNQ5
| 3
SLC6A1 activates KCNQ5. 3 / 3
| 3
sparser
"Here, phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including γ-aminobutyric acid (GABA), which directly activates KCNQ5 and KCNQ3 via W265."
29748663
sparser
"We recently discovered that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
31701029
sparser
"We recently discovered that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
31925247
N-ethylmaleimide affects KCNQ5
| 2 1
N-ethylmaleimide activates KCNQ5. 2 / 2
| 2
sparser
"The M-type current was activated by 1) 10 μM retigabine, an opener of all KCNQ channels except KCNQ1, 2) 10 μM zinc pyrithione, which augments all KCNQ channels except KCNQ3, and 3) 50 μM N-ethylmaleimide, which activates KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3, channels."
22135213
sparser
"Among these, NEM activates the isothiocyanate-activated cation channel TRPA1 [ xref ] and the voltage-gated K + channels (M channels) Kv7.2, Kv7.4, and Kv7.5 [ xref ] (also activated by H 2 O 2 in a dithiothreitol-reversible manner [ xref ])."
23481459
N-ethylmaleimide activates KCNQ5. 1 / 1
| 1
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"The M-type current was activated by 1) 10 muM retigabine, an opener of all KCNQ channels except KCNQ1, 2) 10 muM zinc pyrithione, which augments all KCNQ channels except KCNQ3, and 3) 50 muM N-ethylmaleimide, which activates KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3, channels."
22135213
KCNQ5 affects CALM
| 2 1
CALM binds KCNQ5. 3 / 3
| 2 1
reach
"The maximal level of KCNQ5 and CaM interaction was found when photoreceptors had almost completely disappeared; the KCNQ5 and VGluT1 interaction signal decreased and the KCNQ5 and GFAP interaction increased in the inner retina, while degeneration progressed."
25499209
sparser
"Retinal degeneration progression in P23H-1 rats can be followed by an interaction between KCNQ5 with CaM in an in situ system."
25499209
sparser
"The physical interactions of KCNQ5 with calmodulin (CaM), vesicular glutamate transporter 1 (VGluT1) and glial fibrillary acidic protein (GFAP) were analyzed by in situ proximity ligation assays and were supported by calcium recording."
25499209
Phosphatidylinositol phosphate affects KCNQ5
| 2
Phosphatidylinositol phosphate activates KCNQ5. 2 / 2
| 2
reach
"KCNQ1 and KCNE1, KCNQ4, and KCNQ5 channels are also reactivated by PIP 2 after inhibition by polylysine, showing that all KCNQ family members are PIP 2 sensitive."
22787448
reach
"We therefore asked if pharmacological reduction of PIP 2 levels inhibited KCNQ5 current in the calyx."
21666672
Hsa-miR-7847-3p affects KCNQ5
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Transcriptionally active hsa-miR-7847-3p decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6797-5p affects KCNQ5
2 |
Transcriptionally active hsa-miR-6797-5p decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6782-5p affects KCNQ5
2 |
Transcriptionally active hsa-miR-6782-5p decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-675-3p affects KCNQ5
2 |
Transcriptionally active hsa-miR-675-3p decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23824327
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6747-5p affects KCNQ5
2 |
Transcriptionally active hsa-miR-6747-5p decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-6738-5p affects KCNQ5
2 |
Transcriptionally active hsa-miR-6738-5p decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6515-5p affects KCNQ5
2 |
Transcriptionally active hsa-miR-6515-5p decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-543 affects KCNQ5
2 |
Transcriptionally active hsa-miR-543 decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-5194 affects KCNQ5
2 |
Transcriptionally active hsa-miR-5194 decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-4455 affects KCNQ5
2 |
Transcriptionally active hsa-miR-4455 decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-3650 affects KCNQ5
2 |
Transcriptionally active hsa-miR-3650 decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-223-5p affects KCNQ5
2 |
Transcriptionally active hsa-miR-223-5p decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23824327
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-1914-3p affects KCNQ5
2 |
Transcriptionally active hsa-miR-1914-3p decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-1249-5p affects KCNQ5
2 |
Transcriptionally active hsa-miR-1249-5p decreases the amount of KCNQ5. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Diclofenac affects KCNQ5
| 2
Diclofenac inhibits KCNQ5. 2 / 2
| 2
reach
"Finally, diclofenac, which activates KCNQ2/3 and KCNQ4 channels but inhibits KCNQ5 channels, inhibited the M-type current in the majority of RPE cells but activated it in others."
22135213
reach
"Diclofenac (100 muM) inhibited KCNQ5 channels, reducing maximum conductance by 53%, but increased maximum conductance of KCNQ4 channels by 38%."
20876743
UCL2077 affects KCNQ5
| 2
UCL2077 inhibits KCNQ5.
| 1
UCL2077 inhibits KCNQ5. 1 / 1
| 1
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"Among cloned KCNQ subunits, UCL2077 is reported to inhibit all but KCNQ5, which exhibits voltage dependent potentiation by the drug 27."
21666672
UCL2077 activates KCNQ5.
| 1
UCL2077 activates KCNQ5. 1 / 1
| 1
reach
"In contrast, UCL2077 potentiates KCNQ5 channels at more positive membrane potentials, with little effect at negative membrane potentials."
20843955
SRC affects KCNQ5
1 | 1 1
SRC binds KCNQ5. 1 / 1
1 | 1
hprd
No evidence text available
15304482
SRC binds KCNQ3, KCNQ4, and KCNQ5. 1 / 1
| 1
sparser
"Immunoprecipitation and immunoblot analysis showed Src-dependent phosphotyrosine signals associated with KCNQ3, KCNQ4, and KCNQ5 but not with KCNQ1 or KCNQ2 that may be tyrosine phosphorylation of the channel subunits."
12514204
KCNQ5 affects HCCS
2 |
HCCS binds KCNQ5. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
KCNQ5 affects DISC1
1 1 |
DISC1 binds KCNQ5. 2 / 2
1 1 |
hprd
No evidence text available
12506198
biogrid
No evidence text available
12506198
HCCS affects KCNQ5
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HCCS binds KCNQ5. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
DISC1 affects KCNQ5
1 1 |
DISC1 binds KCNQ5. 2 / 2
1 1 |
hprd
No evidence text available
12506198
biogrid
No evidence text available
12506198
Tetrodotoxin affects KCNQ5
| 1
Tetrodotoxin inhibits KCNQ5. 1 / 1
| 1
reach
"The results were comparable after intracochlear TTX injection, which drastically reduced KCNQ5 immunostaining in MNTB calyces and increased immunolabeling in VCN cell bodies."
25421809
Pyraclofos affects KCNQ5
| 1
Pyraclofos activates KCNQ5. 1 / 1
| 1
reach
"BMS-204352 potentiated the voltage activated KCNQ5 current at all potentials tested."
11890900
MiR190 affects KCNQ5
| 1
MiR190 inhibits KCNQ5. 1 / 1
| 1
reach
"Moreover, KCNQ1 and KCNQ5 are down-regulated by other miRs, namely, miR1/133 and miR190, respectively."
27389411
MiR1/133 affects KCNQ5
| 1
MiR1/133 inhibits KCNQ5. 1 / 1
| 1
reach
"Moreover, KCNQ1 and KCNQ5 are down-regulated by other miRs, namely, miR1/133 and miR190, respectively."
27389411
MiR-499 inhibitor affects KCNQ5
| 1
MiR-499 inhibitor increases the amount of modified KCNQ5. 1 / 1
| 1
reach
"Interestingly, the protein expression of KCNQ5 was significantly upregulated by miR-499 mimic (1.41 +/-0.11 vs. 1.0 +/-0.10 relative units in control, n = 3, P < 0.05) and downregulated by miR-499 inhibitor (0.21 +/-0.05 vs. 1.0 +/-0.25 relative units in control, n = 3, P < 0.05) (XREF_FIG), suggesting that miR-499 does not directly regulate KCNQ5 expression but may be regulating a negative inhibitor of KCNQ5 expression."
23499625
MiR-499 affects KCNQ5
| 1
MiR-499 increases the amount of KCNQ5. 1 / 1
| 1
reach
"Interestingly, the protein expression of KCNQ5 was significantly upregulated by miR-499 mimic (1.41 +/-0.11 vs. 1.0 +/-0.10 relative units in control, n = 3, P < 0.05) and downregulated by miR-499 inhibitor (0.21 +/-0.05 vs. 1.0 +/-0.25 relative units in control, n = 3, P < 0.05) (XREF_FIG), suggesting that miR-499 does not directly regulate KCNQ5 expression but may be regulating a negative inhibitor of KCNQ5 expression."
23499625
Isoprenaline affects KCNQ5
| 1
Isoprenaline phosphorylates KCNQ5. 1 / 1
| 1
sparser
"Correspondingly, proximity ligation assays indicated that isoproterenol induced PKA-dependent phosphorylation of exogenously expressed Kv7.5 channel subunits, but not of Kv7.4 subunits."
26700561
Hsa-miR-6507-5p affects KCNQ5
1 |
Transcriptionally active hsa-miR-6507-5p decreases the amount of KCNQ5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-5693 affects KCNQ5
1 |
Transcriptionally active hsa-miR-5693 decreases the amount of KCNQ5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-5096 affects KCNQ5
1 |
Transcriptionally active hsa-miR-5096 decreases the amount of KCNQ5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-4999-3p affects KCNQ5
1 |
Transcriptionally active hsa-miR-4999-3p decreases the amount of KCNQ5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-4282 affects KCNQ5
1 |
Transcriptionally active hsa-miR-4282 decreases the amount of KCNQ5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-194-3p affects KCNQ5
1 |
Transcriptionally active hsa-miR-194-3p decreases the amount of KCNQ5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-190a-5p affects KCNQ5
1 |
Transcriptionally active hsa-miR-190a-5p decreases the amount of KCNQ5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24446351
Hsa-miR-144-3p affects KCNQ5
1 |
Transcriptionally active hsa-miR-144-3p decreases the amount of KCNQ5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-139-5p affects KCNQ5
1 |
Transcriptionally active hsa-miR-139-5p decreases the amount of KCNQ5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-101-3p affects KCNQ5
1 |
Transcriptionally active hsa-miR-101-3p decreases the amount of KCNQ5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Estrogen affects KCNQ5
| 1
Estrogen increases the amount of KCNQ5. 1 / 1
| 1
reach
"Previously, we have shown that estrogen replacement in ovariectomized female guinea pigs increased the expression of KCNQ5 in the arcuate nucleus after both 24 hr and long-term treatment."
21849543
Celecoxib affects KCNQ5
| 1
Celecoxib inhibits KCNQ5. 1 / 1
| 1
reach
"We conclude that celecoxib inhibits calcium responses in VSMCs by enhancing KCNQ5 currents and suppressing L-type calcium currents, which ultimately reduces vascular tone."
19605525
XE991 affects KCNQ5
| 1
XE991 inhibits KCNQ5. 1 / 1
| 1
reach
"However, as previously described for the KCNQ4 current (Schroder et al., 2001), a brief transient increase in the amplitude of the tail current measured at -60 mV was observed before deactivation in the absence or presence of the compound, which could be explained as recovery from a very weak inactivation.XE991 is a blocker of M-type currents, and recently Schroeder et al. (2000) have shown that the KCNQ5 current is also blocked by the XE991 in Xenopus oocytes."
11890900
TWIST1 affects KCNQ5
| 1
TWIST1 binds KCNQ5. 1 / 1
| 1
sparser
"In addition to the top significant SNPs rs2917454 and rs6907229, imputation analysis uncovered additional genetic variants in KCNMA1 and in KCNQ5 that were associated with CRS."
24595210
PPY affects KCNQ5
| 1
PPY activates KCNQ5. 1 / 1
| 1
reach
"The KCNQ5 potassium channel from mouse : a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes."
15963599
Kcnq4/5 affects KCNQ5
| 1
Kcnq4/5 activates KCNQ5. 1 / 1
| 1
reach
"This branching pattern can be explained by two duplication events in the vertebrate lineage, where a single proto-orthologue to Kcnq2/3/4/5, duplicated to create two ancestor genes to Kcnq2/3 and Kcnq4/5 which both duplicated again to produce Kcnq2, kcnq3, kcnq4 and kcnq5 genes as conserved in current vertebrate genomes."
19200367
Kcnq2/3 affects KCNQ5
| 1
Kcnq2/3 activates KCNQ5. 1 / 1
| 1
reach
"This branching pattern can be explained by two duplication events in the vertebrate lineage, where a single proto-orthologue to Kcnq2/3/4/5, duplicated to create two ancestor genes to Kcnq2/3 and Kcnq4/5 which both duplicated again to produce Kcnq2, kcnq3, kcnq4 and kcnq5 genes as conserved in current vertebrate genomes."
19200367
KCNQ5 affects potassium(1+)
| 1
KCNQ5 activates potassium(1+). 1 / 1
| 1
reach
"The water channel AQP1 and the main calcium regulated ion channel in chondrocytes TRPV4 are strongly increased in Group B. XREF_BIBR Also increased in Group B are other calcium activated potassium channels including KCNN3, 4, XREF_BIBR the voltage sensitive calcium activated chloride channel ANO1 and potassium channels KCNQ5, KCNS3 and KCTD12, KCNMB4 (XREF_TABLE)."
29273645
KCNQ5 affects TWIST1
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TWIST1 binds KCNQ5. 1 / 1
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sparser
"In addition to the top significant SNPs rs2917454 and rs6907229, imputation analysis uncovered additional genetic variants in KCNMA1 and in KCNQ5 that were associated with CRS."
24595210
KCNQ5 affects PTCH1, and spef1
| 1
KCNQ5 binds PTCH1 and spef1. 1 / 1
| 1
sparser
"In the first, we constructed a mutant tetraethylammonium ion-sensitive KCNQ4 subunit and tested its assembly with KCNQ5 by patch clamp analysis of the tetraethylammonium ion sensitivity of the resulting current; however, those data were not conclusive."
18786918
KCNQ5 affects HAUS3
| 1
HAUS3 binds KCNQ5. 1 / 1
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sparser
"Results of RT-qPCR showed that the levels of lncRNAs MTCO2P12, KCNQ5-IT1 and RP11-83J16.1 were increased, whereas lncRNAs LINC00570, RP11-342M1.6, and REXO1L4P were decreased in RA patients compared to controls."
32355550
KCNQ5 affects GFAP
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GFAP binds KCNQ5. 1 / 1
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"The maximal level of KCNQ5 and CaM interaction was found when photoreceptors had almost completely disappeared; the KCNQ5 and VGluT1 interaction signal decreased and the KCNQ5 and GFAP interaction increased in the inner retina, while degeneration progressed."
25499209
KCNQ5 affects CDH
| 1
KCNQ5 activates CDH. 1 / 1
| 1
reach
"We hypothesized that KCNQ1, KCNQ4, and KCNQ5 expression is altered in the pulmonary vasculature of nitrofen induced CDH rats."
28189443
KCNQ5 affects CALM3
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CALM3 binds KCNQ5. 1 / 1
1 |
hprd
No evidence text available
12032157
KCNQ5 affects CALM2
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CALM2 binds KCNQ5. 1 / 1
1 |
hprd
No evidence text available
12032157
KCNQ5 affects CALM1
1 |
CALM1 binds KCNQ5. 1 / 1
1 |
hprd
No evidence text available
12032157
KCNQ3 affects KCNQ4, KCNQ5, and SRC
| 1
SRC binds KCNQ3, KCNQ4, and KCNQ5. 1 / 1
| 1
sparser
"Immunoprecipitation and immunoblot analysis showed Src-dependent phosphotyrosine signals associated with KCNQ3, KCNQ4, and KCNQ5 but not with KCNQ1 or KCNQ2 that may be tyrosine phosphorylation of the channel subunits."
12514204
KCNQ channel opener affects KCNQ5
| 1
KCNQ channel opener activates KCNQ5. 1 / 1
| 1
reach
"Zinc pyrithione (ZnPy) is a newly identified KCNQ channel opener, which potently activates KCNQ2, KCNQ4, and KCNQ5."
18490447
HAUS3 affects KCNQ5
| 1
HAUS3 binds KCNQ5. 1 / 1
| 1
sparser
"Results of RT-qPCR showed that the levels of lncRNAs MTCO2P12, KCNQ5-IT1 and RP11-83J16.1 were increased, whereas lncRNAs LINC00570, RP11-342M1.6, and REXO1L4P were decreased in RA patients compared to controls."
32355550
GS26575 affects KCNQ5
| 1
GS26575 inhibits KCNQ5. 1 / 1
| 1
reach
"KCNQ5 is inhibited by the M1 muscarinic receptor activation and shows pharmacological properties suggesting that it plays a role in generating M currents or M like currents (Lerche et al., 2000; Schroeder et al., 2000)."
11890900
GFAP affects KCNQ5
| 1
GFAP binds KCNQ5. 1 / 1
| 1
reach
"The maximal level of KCNQ5 and CaM interaction was found when photoreceptors had almost completely disappeared; the KCNQ5 and VGluT1 interaction signal decreased and the KCNQ5 and GFAP interaction increased in the inner retina, while degeneration progressed."
25499209
EZG affects KCNQ5
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EZG activates KCNQ5. 1 / 1
| 1
reach
"XREF_BIBR However, KCNQ4 and KCNQ5 potassium channels are activated by EZG and may be found in cochlear hair cells XREF_BIBR or smooth muscle."
22888276
EB affects KCNQ5
| 1
EB increases the amount of KCNQ5. 1 / 1
| 1
reach
"We found that EB significantly increased the expression of KCNQ5 and Kv4.1 and decreased expression of KCNQ3 and AKAP in the rostral arcuate."
17595223
CYP7B1 affects KCNQ5, and PPP3CC
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CYP7B1 binds KCNQ5 and PPP3CC. 1 / 1
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sparser
"The genetic component highlighted genes including PPP3CC, KCNQ5, and CYP7B1 which are directly associated with brain function or mental disorders."
25571521
CALM3 affects KCNQ5
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CALM3 binds KCNQ5. 1 / 1
1 |
hprd
No evidence text available
12032157
CALM2 affects KCNQ5
1 |
CALM2 binds KCNQ5. 1 / 1
1 |
hprd
No evidence text available
12032157
CALM1 affects KCNQ5
1 |
CALM1 binds KCNQ5. 1 / 1
1 |
hprd
No evidence text available
12032157
BMS-204352 affects KCNQ5
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BMS-204352 activates KCNQ5. 1 / 1
| 1
reach
"Application of BMS-204352 also slowed the voltage independent KCNQ5 channel deactivation."
11890900
BBR affects KCNQ5
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BBR activates KCNQ5. 1 / 1
| 1
reach
"At 10 muM, BBR potentiated KCNQ1, KCNQ4, and KCNQ5 but not KCNQ3."
25735002
AVP affects KCNQ5
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AVP activates KCNQ5. 1 / 1
| 1
reach
"However physiological concentrations of AVP induced additional depolarization and increased Ca 2+ spike frequency in KCNQ5 knockdown cells."
19246091
ADRB affects KCNQ5
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ADRB activates KCNQ5. 1 / 1
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sparser
"A phospho-mimic mutation (S53D) exhibited characteristics of βAR-activated Kv7.5."
30061510