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phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading

CALM affects KCNQ3
| 3 13
CALM activates KCNQ3.
| 8
CALM bound to KCNQ2 activates KCNQ3. 5 / 5
| 5
reach
"Disruption of CaM binding to KCNQ2 impairs trafficking of HA-KCNQ3 and KCNQ2 channels from the ER to the axon."
reach
"Disruption of calmodulin binding to KCNQ2 also impairs enrichment of heteromeric KCNQ2 and KCNQ3 channels at the axonal surface by blocking their trafficking from the endoplasmic reticulum to the axon."
reach
"To test whether CaM binding to KCNQ2 promotes trafficking of HA-KCNQ3 and KCNQ2 channels from the ER to the axon, we performed pulse-chase experiments after removal of BFA."
reach
"Disruption of CaM binding to KCNQ2 inhibits enrichment of HA-KCNQ3 and KCNQ2 channels at the axonal surface."
reach
"These results together indicate that disruption of CaM interaction with KCNQ2 by the A343D mutation impairs the trafficking of HA-KCNQ3 and KCNQ2 channels from the ER to the axon."
CALM activates KCNQ3. 3 / 3
| 3
reach
"Further, we show that CaM 1234 restores the assembly of KCNQ3 with the KCNQ2-L638P subunit which bears a mutation in its SI domain."
reach
"Co-transfection with GFP tagged CaM or CaM 1234 did not increase KCNQ2-L586P and KCNQ3 currents (Figs. 6 B-C)."
reach
"Recently, it has been shown by XREF_BIBR that KCNQ2 BNFS causing mutations express alterations in CaM binding and that in some cases CaM overexpression restored normal function of the KCNQ2 and KCNQ3 induced channels."
CALM binds KCNQ3.
| 3 2
| 1 2
sparser
"In this study, we demonstrate that the binding of CaM to KCNQ3 subunits is essential for their heteromeric association with KCNQ2."
reach
"In this study, we demonstrate that the binding of CaM to KCNQ3 subunits is essential for their heteromeric association with KCNQ2."
reach
"In addition, Ca 2 + / CaM binds the 1-5-10 motifs of both KCNQ2 and KCNQ3 with a low-affinity, and favours subunit interaction."
CALM binds KCNQ2 and KCNQ3. 1 / 1
| 1
sparser
"Recent studies have shown that calmodulin (CaM) binds to the KCNQ2 and KCNQ3 C termini and may function as an auxiliary channel subunit xref , xref , xref ."
CALM binds KCNQ2, KCNQ3, and cooH. 1 / 1
| 1
sparser
"Using similar biochemical approaches, both papers demonstrated CaM binding to the intracellular COOH-terminal domains of KCNQ2 and KCNQ3 channels, and disruption of binding by mutagenesis of residues at regions similar to those named IQ 1 and IQ 2 in the present study."
CALM inhibits KCNQ3.
| 2
CALM inhibits KCNQ3. 2 / 2
| 2
reach
"Coexpression of CaM in Chinese hamster ovary (CHO) cells strongly reduced currents of KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3."
reach
"Moreover, overexpression of CaM reduced current amplitudes of KCNQ2, KCNQ4, and KCNQ5, but not those of KCNQ1 and KCNQ3."
CALM increases the amount of KCNQ3.
| 1
CALM increases the amount of KCNQ3. 1 / 1
| 1
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"We found that CaM 1234 significantly increased the surface expression of KCNQ2-L638P and KCNQ3 subunits."
Ezogabine affects KCNQ3
1 | 1 6
Ezogabine activates KCNQ3.
1 | 1 5
1 | 1 5
reach
"Remarkably, however, this single atom alteration in each of the KCNQ3 * subunits entirely abolishes retigabine activation of KCNQ3 * channels (XREF_FIG)."
sparser
"Retigabine activates mainly heteromeric Kv7.2 and Kv7.3 channels and as a result causes changes in resting membrane potential towards more negative levels (ie hyperpolarization)."
reach
"Retigabine potentiation of KCNQ3 * channels was retained with F 3 -Trp substitution at Trp265 (XREF_FIG), a substitution that still potently diminishes the negative electrostatic potential on the face of the side chain (XREF_FIG), indicating that a cation-pi interaction of Trp265 with retigabine or some other entity (perhaps another channel residue) is not required for retigabine effects."
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"The M-type current was activated by 1) 10 muM retigabine, an opener of all KCNQ channels except KCNQ1, 2) 10 muM zinc pyrithione, which augments all KCNQ channels except KCNQ3, and 3) 50 muM N-ethylmaleimide, which activates KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3, channels."
reach
"Recently, Wickenden et al. (2001) have also shown that retigabine can activate the KCNQ5 and KCNQ3 heteromer expressed in CHO cells."
reach
"Moreover, KCNQ3 and KCNQ5 channels are potently activated by the anticonvulsant retigabine (Wickenden et al., 2001)."
signor
No evidence text available
Ezogabine increases the amount of KCNQ3.
| 1
Ezogabine increases the amount of KCNQ3. 1 / 1
| 1
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"Retigabine activates KCNQ2 and KCNQ3 expressed in Chinese Hamster Ovary (CHO) cells with an EC 50 value of 1.7 (Rundfeldt and Netzer, 2000) and 0.34 muM when KCNQ2 and KCNQ3 were expressed in Xenopus oocytes (Wickenden et al., 2000)."
| 6
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"We recently discovered that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
reach
"We recently discovered that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
reach
"We recently discovered that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
reach
"We recently discovered that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
reach
"Here, phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid (GABA), which directly activates KCNQ5 and KCNQ3 via W265."
reach
"Here, phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid (GABA), which directly activates KCNQ5 and KCNQ3 via W265."
KCNQ3 affects CALM
| 3 3
KCNQ3 binds CALM.
| 3 2
| 1 2
sparser
"In this study, we demonstrate that the binding of CaM to KCNQ3 subunits is essential for their heteromeric association with KCNQ2."
reach
"In this study, we demonstrate that the binding of CaM to KCNQ3 subunits is essential for their heteromeric association with KCNQ2."
reach
"In addition, Ca 2 + / CaM binds the 1-5-10 motifs of both KCNQ2 and KCNQ3 with a low-affinity, and favours subunit interaction."
CALM binds KCNQ2 and KCNQ3. 1 / 1
| 1
sparser
"Recent studies have shown that calmodulin (CaM) binds to the KCNQ2 and KCNQ3 C termini and may function as an auxiliary channel subunit xref , xref , xref ."
CALM binds KCNQ2, KCNQ3, and cooH. 1 / 1
| 1
sparser
"Using similar biochemical approaches, both papers demonstrated CaM binding to the intracellular COOH-terminal domains of KCNQ2 and KCNQ3 channels, and disruption of binding by mutagenesis of residues at regions similar to those named IQ 1 and IQ 2 in the present study."
KCNQ3 activates CALM.
| 1
KCNQ3-A518D activates CALM. 1 / 1
| 1
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"The equivalent mutation in KCNQ3 (A518D) also led to the formation of non functional channels, suggesting a divergent role of CaM according to KCNQ channel type."
Calcium(2+) affects KCNQ3
| 2 2
| 2 1
sparser
"These results demonstrated that CaM-mediated benefits depend on the binding of Ca 2 + /CaM to the 1–5–10 motifs of KCNQ2 and KCNQ3 subunits."
sparser
"In addition, Ca 2 + /CaM binds the 1–5–10 motifs of both KCNQ2 and KCNQ3 with a low-affinity, and favours subunit interaction ( Fig. 7 )."
reach
"A number of in vitro biochemical studies have reported that Ca 2 + / CaM binds the B helices of KCNQ2, KCNQ3, and KCNQ4 (Alaimo et al., 2013; Xu et al., 2013)."
Calcium(2+) inhibits KCNQ3.
| 1
| 1
reach
"Coexpression of Ca 2+ -insensitive CaM modestly reduces enrichment of HA-KCNQ3 and KCNQ2 channels at the axonal surface."
| 4
KCNQ3 activates potassium(1+).
| 3
| 3
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"Co-expression of KCNQ2 and KCNQ3 leads to a large increase of the potassium current, suggesting that the proteins interact as heterodimers."
reach
"It is suggested that KCNQ2 and KCNQ3 contribute to the formation of the native M-current, a slowly activating and deactivating potassium conductance."
reach
"KCNQ2 and KCNQ3 K+ channel subunits underlie the muscarinic regulated K+ current (I (KM)), a widespread regulator of neuronal excitability."
| 1
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"Changes in KCNQ3 activation alone have been linked with induction of tinnitus [XREF_BIBR], while the dimerization of KCNQ3 with other potassium channels seems to be essential for hearing."
ANK3 affects KCNQ3
| 2 2
ANK3 binds KCNQ3.
| 2 1
| 1 1
reach
"We also found suggestive evidence of interactions between ANK3 and KCNQ3 (p = 1.86 x 10 -5)."
sparser
"We also found suggestive evidence of interactions between ANK3 and KCNQ3 ( p = 1.86 × 10 -5 )."
ANK3 binds KCNQ2, KCNQ3, and voltage-gated potassium channel. 1 / 1
| 1
sparser
"In line with this role, ANK3 interacts directly with KCNQ2, which is expressed in the brain and forms homomeric and heteromeric voltage-gated potassium channels with another member of the KCNQ family, KCNQ3."
ANK3 activates KCNQ3.
| 1
ANK3 activates KCNQ3. 1 / 1
| 1
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"ANK3 helps to direct the localization of the KCNQ2 and KCNQ3 channels to the axonal initial segment (AIS) of neurons and nodes of Ranvier."
SP1 affects KCNQ3
1 | 1 1
SP1 increases the amount of KCNQ3.
1 | 1
SP1 increases the amount of KCNQ3. 2 / 2
1 | 1
reach
"We show that the transcription factor Sp1 activates expression of both KCNQ2 and KCNQ3, whereas the transcriptional repressor REST (repressor element 1 silencing transcription factor) represses expression of both of these genes."
trrust
No evidence text available
SP1 activates KCNQ3.
| 1
SP1 activates KCNQ3. 1 / 1
| 1
sparser
"SP1 has a long-lasting increased activity in kainate-induced epilepsy model, and neonatal epilepsy-associated KCNQ2 and KCNQ3 genes are activated by SP1 (Feng et al., xref ; Mucha et al., xref )."
SLC6A1 affects KCNQ3
| 3
SLC6A1 activates KCNQ3. 3 / 3
| 3
sparser
"Here, phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including γ-aminobutyric acid (GABA), which directly activates KCNQ5 and KCNQ3 via W265."
sparser
"We recently discovered that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
sparser
"We recently discovered that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and KCNQ5."
OGT affects KCNQ3
| 2 1
| 2 1
sparser
"For example, Ruan et al. have shown that voltage-dependent K + channel KCNQ3 (Kv7.3) interacts with OGT and it is probably O-GlcNAc modified at threonine 655 in neurons [ xref ]."
sparser
"In Agrp neurons fasting increased the binding of OGT to the potassium channel Kcnq3 (Ruan et al. xref ) and glucose deprivation in N2a cells targeted OGT via the protein p38 to a different set of substrates (Cheung and Hart xref )."
reach
"For example, Ruan et al. have shown that voltage dependent K + channel KCNQ3 (Kv7.3) interacts with OGT and it is probably O-GlcNAc modified at threonine 655 in neurons [XREF_BIBR]."
KCNQ3 affects calcium(2+)
| 2 1
sparser
"These results demonstrated that CaM-mediated benefits depend on the binding of Ca 2 + /CaM to the 1–5–10 motifs of KCNQ2 and KCNQ3 subunits."
sparser
"In addition, Ca 2 + /CaM binds the 1–5–10 motifs of both KCNQ2 and KCNQ3 with a low-affinity, and favours subunit interaction ( Fig. 7 )."
reach
"A number of in vitro biochemical studies have reported that Ca 2 + / CaM binds the B helices of KCNQ2, KCNQ3, and KCNQ4 (Alaimo et al., 2013; Xu et al., 2013)."
KCNQ3 affects OGT
| 2 1
| 2 1
sparser
"For example, Ruan et al. have shown that voltage-dependent K + channel KCNQ3 (Kv7.3) interacts with OGT and it is probably O-GlcNAc modified at threonine 655 in neurons [ xref ]."
sparser
"In Agrp neurons fasting increased the binding of OGT to the potassium channel Kcnq3 (Ruan et al. xref ) and glucose deprivation in N2a cells targeted OGT via the protein p38 to a different set of substrates (Cheung and Hart xref )."
reach
"For example, Ruan et al. have shown that voltage dependent K + channel KCNQ3 (Kv7.3) interacts with OGT and it is probably O-GlcNAc modified at threonine 655 in neurons [XREF_BIBR]."
KCNQ3 affects KCN
| 2 1
KCN binds KCNQ2 and KCNQ3. 2 / 2
| 2
sparser
"M-current formed by KCNQ2 and KCNQ3 potassium channel subunits has a key role in the stabilization of membrane potential and thus in neuronal excitability."
sparser
"6 M-current formed by KCNQ2 and KCNQ3 potassium channel subunits has a key role in stabilisation of membrane potential and thus in neural excitability."
| 1
reach
"Calmodulin (CaM) was identified as a KCNQ2 and KCNQ3 potassium channel binding protein, using a yeast two-hybrid screen."
KCNQ3 affects ANK3
| 2 1
| 1 1
reach
"We also found suggestive evidence of interactions between ANK3 and KCNQ3 (p = 1.86 x 10 -5)."
sparser
"We also found suggestive evidence of interactions between ANK3 and KCNQ3 ( p = 1.86 × 10 -5 )."
ANK3 binds KCNQ2, KCNQ3, and voltage-gated potassium channel. 1 / 1
| 1
sparser
"In line with this role, ANK3 interacts directly with KCNQ2, which is expressed in the brain and forms homomeric and heteromeric voltage-gated potassium channels with another member of the KCNQ family, KCNQ3."
KCNQ2 affects KCNQ3, and STX1A
| 3
| 3
sparser
"Following our previous studies, in which we characterized syntaxin 1A's interactions with Kv channels xref – xref , xref , xref , we studied the interaction of syntaxin 1A with KCNQ2, KCNQ2/3 and KCNQ3 channels in the heterologous expression system of Xenopus oocytes, where biochemical and electrophysiological analyses can be performed simultaneously."
sparser
"Next, we assessed the functional consequences of syntaxin 1A binding to the KCNQ2, KCNQ2/3 and KCNQ3 channels by two-electrode voltage clamp analysis of currents evoked by depolarizing potentials in oocytes coexpressing the subunits with syntaxin 1A. However, whereas oocytes expressing KCNQ2 alone or together with KCNQ3 exhibited large outward non-inactivating potassium currents, oocytes expressing KCNQ3 alone did not exhibit any detectable current, in agreement with previous studies xref , xref – xref ."
sparser
"In addition, we compared the binding of brain syntaxin 1A to KCNQ2 and KCNQ3 in a pull-down assay from synaptosomes ( xref )."
KCN affects KCNQ3
| 2 1
KCN binds KCNQ2 and KCNQ3. 2 / 2
| 2
sparser
"M-current formed by KCNQ2 and KCNQ3 potassium channel subunits has a key role in the stabilization of membrane potential and thus in neuronal excitability."
sparser
"6 M-current formed by KCNQ2 and KCNQ3 potassium channel subunits has a key role in stabilisation of membrane potential and thus in neural excitability."
| 1
reach
"Calmodulin (CaM) was identified as a KCNQ2 and KCNQ3 potassium channel binding protein, using a yeast two-hybrid screen."
| 1 1
| 1
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"Importantly, reduction of phosphatidylinositol 4,5-bisphosphate (PIP2) causes KCNQ3 to become sensitive to ZnPy but lose sensitivity to retigabine."
sparser
"Fitting the data for WT and mutant channels to an activation mechanism with independent PI(4,5)P 2 binding to two Kv7.2 and two Kv7.3 subunits suggests that the two components of the M-channel activation curve correspond to the interaction of PI(4,5)P 2 with the Kv7.3 and Kv7.2 subunits, respectively, that channels can open when only the two Kv7.3 subunits have bound DiC 8 -PI(4,5)P 2 , and that maximum channel opening requires binding to all four subunits."
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Transcriptionally active hsa-miR-6867-5p decreases the amount of KCNQ3. 2 / 2
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biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-574-5p decreases the amount of KCNQ3. 2 / 2
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biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-4455 decreases the amount of KCNQ3. 2 / 2
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biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
Histamine affects KCNQ3
| 2
Histamine inhibits KCNQ3.
| 1
| 1
reach
"Histamine inhibits KCNQ2 and KCNQ3 channel current via recombinant histamine H (1) receptors."
Histamine activates KCNQ3.
| 1
| 1
reach
"However, in previous studies, we found that activation of histamine H 1 receptors significantly decreased both the fast and slow time constants of KCNQ2 and KCNQ3 channel deactivation (Guo and Schofield, 2002b)."
Gabapentin affects KCNQ3
| 2
| 2
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"Gabapentin activation of KCNQ2/3 (EC50 = 4.2 nM) or homomeric KCNQ3 * (EC50 = 5.3 nM) channels requires KCNQ3-W265, a conserved tryptophan in KCNQ3 transmembrane segment 5."
reach
"Here, we report that gabapentin is a potent activator of the heteromeric KCNQ2/3 voltage gated potassium channel, the primary molecular correlate of the neuronal M-current, and also homomeric KCNQ3 and KCNQ5 channels."
ApoCaM affects KCNQ3
| 2
KCNQ3 binds apoCaM. 1 / 1
| 1
reach
"We interpret this as an indication that apoCaM binds the intact C-termini of KCNQ2 and KCNQ3 channels, and promotes their multimerization."
KCNQ3 binds IQ domain and apoCaM. 1 / 1
| 1
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"We thus propose that apoCaM binds the IQ domain of KCNQ3 with a high-affinity, and coordinates the association of the KCNQ2/3 complex."
| 2
| 2
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"These trafficking differences could be due to channel retention in the smooth ER cisterns found at the proximal AIS XREF_BIBR, XREF_BIBR, XREF_BIBR, and/or due to the presence of KCNQ3, the dominant subunit that mediates KCNQ2 and KCNQ3 channel localization to the AIS by binding to ankyrin-G XREF_BIBR, XREF_BIBR, XREF_BIBR."
reach
"Deletion of the ankyrin G binding motif of KCNQ2 and KCNQ3 disrupts the channel AIS localization."
KCNQ3 affects ezogabine
| 2
| 2
reach
"Remarkably, however, this single atom alteration in each of the KCNQ3 * subunits entirely abolishes the ability of retigabine to activate KCNQ3 * channels (XREF_FIG)."
reach
"Remarkably, however, this single atom alteration in each of the KCNQ3 * subunits entirely abolishes retigabine activation of KCNQ3 * channels (XREF_FIG)."
KCNQ3 affects apoCaM
| 2
KCNQ3 binds apoCaM. 1 / 1
| 1
reach
"We interpret this as an indication that apoCaM binds the intact C-termini of KCNQ2 and KCNQ3 channels, and promotes their multimerization."
KCNQ3 binds IQ domain and apoCaM. 1 / 1
| 1
reach
"We thus propose that apoCaM binds the IQ domain of KCNQ3 with a high-affinity, and coordinates the association of the KCNQ2/3 complex."
KCNQ3 affects CALM1
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hprd
No evidence text available
hprd
No evidence text available
KCNQ3 affects Akap5
| 1 1
| 1
reach
"Those transfected with KCNQ3 and AKAP150 resulted in a somewhat more skewed distribution towards KCNQ3 and AKAP150 complexes (XREF_SUPPLEMENTARY), but the unknown expression of KCNQ2 or KCNQ3 in such cells precludes further interpretation."
| 1
sparser
"The fraction of complexes representing KCNQ2 or KCNQ3 homomers associated with AKAP150 was very low, as was the fraction of KCNQ2/3 heteromers unpaired with AKAP150."
KCNQ2 affects KCNQ3, and voltage-gated potassium channel
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KCNQ2 binds KCNQ3 and voltage-gated potassium channel. 2 / 2
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sparser
"Mutations in the voltage-gated potassium channel subunit genes KCNQ2 and KCNQ3 are associated with benign familial neonatal seizures (Leppert and Singh, xref )."
sparser
"In human bodies, ankyrins have been confirmed to bind to the voltage-gated potassium channel subunits KCNQ2 and KCNQ3, regulating their normal functions [ xref ]."
KCNQ2 affects KCNQ3, and syntaxin
| 2
| 2
sparser
"To investigate the possible physiological impact of the interaction of syntaxin with KCNQ2 and KCNQ3 we performed numerical simulations."
sparser
"It is important to note that our modeling was designed to qualitatively investigate the physiological impact of the interaction of syntaxin with KCNQ2 and KCNQ3."
KCNQ2 affects KCNQ3, and calcium(2+)
| 2
sparser
"These results demonstrated that CaM-mediated benefits depend on the binding of Ca 2 + /CaM to the 1–5–10 motifs of KCNQ2 and KCNQ3 subunits."
sparser
"In addition, Ca 2 + /CaM binds the 1–5–10 motifs of both KCNQ2 and KCNQ3 with a low-affinity, and favours subunit interaction ( Fig. 7 )."
KCN affects KCNQ2, and KCNQ3
| 2
KCN binds KCNQ2 and KCNQ3. 2 / 2
| 2
sparser
"M-current formed by KCNQ2 and KCNQ3 potassium channel subunits has a key role in the stabilization of membrane potential and thus in neuronal excitability."
sparser
"6 M-current formed by KCNQ2 and KCNQ3 potassium channel subunits has a key role in stabilisation of membrane potential and thus in neural excitability."
IQ affects KCNQ3
| 1 1
IQ binds KCNQ3.
| 1
| 1
sparser
"We thus propose that apoCaM binds the IQ domain of KCNQ3 with a high-affinity, and coordinates the association of the KCNQ2/3 complex ( Fig. 7 )."
IQ activates KCNQ3.
| 1
IQ activates KCNQ3. 1 / 1
| 1
reach
"The wild type and R353G mutant channels were also found at the AIS and distal axons, regions where the A343D mutant channels and the CD4-KDEL proteins were absent (XREF_FIG), indicating that the A343D mutation in the IQ motif of KCNQ2 enhances the localization of HA-KCNQ3 and KCNQ2 channels in the ER."
GNAS affects KCNQ3
| 2
GNAS methylates KCNQ3. 2 / 2
| 2
sparser
"DNA methylation analysis of CpGs within an alternative exonic region of KCNQ3 exon 11 demonstrated significantly lower methylation in BPD, and correlated significantly with KCNQ3 mRNA levels."
sparser
"Lower KCNQ3 exon 11 DNA methylation was observed in the Stanley Medical Research Institute replication cohort, although only after correcting for mood stabilizer status."
CK2 affects KCNQ3
| 1 1
CK2 phosphorylates KCNQ3. 2 / 2
| 1 1
reach
"Phosphorylation of KCNQ2 and KCNQ3 anchor domains by protein kinase CK2 (CK2) augments binding, as previously shown for Nav1.2."
sparser
"Phosphorylation of KCNQ2 and KCNQ3 anchor domains by protein kinase CK2 (CK2) augments binding, as previously shown for Nav1.2."
CALM1 affects KCNQ3
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hprd
No evidence text available
hprd
No evidence text available
Akap5 affects KCNQ3
| 1 1
| 1
reach
"Those transfected with KCNQ3 and AKAP150 resulted in a somewhat more skewed distribution towards KCNQ3 and AKAP150 complexes (XREF_SUPPLEMENTARY), but the unknown expression of KCNQ2 or KCNQ3 in such cells precludes further interpretation."
| 1
sparser
"The fraction of complexes representing KCNQ2 or KCNQ3 homomers associated with AKAP150 was very low, as was the fraction of KCNQ2/3 heteromers unpaired with AKAP150."
Receptors affects KCNQ3
| 1
Receptors inhibits KCNQ3. 1 / 1
| 1
reach
"In our studies, KCNQ2 and KCNQ3 channels were inhibited by activation of muscarinic m1, m3, and m5 receptors, but not m2 or m4 receptors."
| 1
reach
"Changes in KCNQ3 activation alone have been linked with induction of tinnitus [XREF_BIBR], while the dimerization of KCNQ3 with other potassium channels seems to be essential for hearing."
| 1
sparser
"M-channels formed by KCNQ2 and KCNQ3 subunits may also have allosteric coupling as suggested by the report that these channels can open even when only the high affinity KCNQ3 subunits are bound to PIP 2 (Telezhkin et al., xref ), suggesting that opening is not concerted as in the linear scheme (Figure xref )."
| 1
reach
"Heteromeric KCNQ2 and KCNQ3 currents were modulated by the muscarinic agonist oxotremorine-M (oxo-M) in a manner having all of the characteristics of modulation of native M current in sympathetic neurons."
Oxo-M affects KCNQ3
| 1
Oxo-M activates KCNQ3. 1 / 1
| 1
reach
"Homomeric KCNQ2 and KCNQ3 channels also expressed well and were modulated individually by oxo-M, suggesting that the motifs for modulation are present on both channel subtypes."
Muscarinic receptors affects KCNQ3
| 1
Muscarinic receptors activates KCNQ3. 1 / 1
| 1
reach
"Therefore, we investigated if activation of other muscarinic receptors could also modulate KCNQ2 and KCNQ3 channels."
Muscarinic affects KCNQ3
| 1
Muscarinic inhibits KCNQ3. 1 / 1
| 1
reach
"In the present studies, we tested if KCNQ2 and KCNQ3 channel currents (M-current) could be inhibited by activation of muscarinic m5 receptors transiently transfected into human embryonic kidney (HEK) 293T cells.HEK293T cells were kindly provided by Dr. Jamboor K. Vishwanatha (University of Nebraska Medical Center, Omaha)."
M3 affects KCNQ3
| 1
M3 inhibits KCNQ3. 1 / 1
| 1
reach
"In our studies, KCNQ2 and KCNQ3 channels were inhibited by activation of muscarinic m1, m3, and m5 receptors, but not m2 or m4 receptors."
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Transcriptionally active hsa-miR-7113-3p decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-6867-3p decreases the amount of KCNQ3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-6752-3p decreases the amount of KCNQ3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-6727-3p decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-629-3p decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
Hsa-miR-567 affects KCNQ3
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Transcriptionally active hsa-miR-567 decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-511-3p decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4760-3p decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4722-3p decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4713-5p decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4685-3p decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4469 decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4287 decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
Hsa-miR-297 affects KCNQ3
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Transcriptionally active hsa-miR-297 decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-223-5p decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-192-3p decreases the amount of KCNQ3. 1 / 1
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biopax:mirtarbase
No evidence text available
Ethanol affects KCNQ3
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Ethanol decreases the amount of KCNQ3. 1 / 1
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"Query of the GeneWeaver system (XREF_TABLE) revealed that chronic alcohol exposure decreased Kcnq3 transcript levels in the NAc."
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"To determine if ER retention of KCNQ3 channels resulted in activation of the UPR, we analyzed transfected samples for upregulation of the molecular chaperone, GRP78."
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"In contrast, mutating the endogenous cysteine C106A in KCNQ2 S1 produced a significant decline in Cd 2+ inhibition of the C106A-R198C KCNQ2/WT KCNQ3 heteromer as compared with the Cd 2+ inhibitory effect on R198C KCNQ2/WT KCNQ3 or on R198C KCNQ2 and C136A KCNQ3 heteromers (XREF_TABLE and XREF_FIG, third row)."
ApoCaM proteins affects KCNQ3
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KCNQ3 binds apoCaM proteins. 1 / 1
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"Considering a very low level of intracellular Ca 2+ in dissociated hippocampal cultured neurons at rest XREF_BIBR, we propose that apoCaM proteins bind simultaneously to helices A and B of KCNQ2 and KCNQ3 at the ER, with the IQ motif in helix A of KCNQ2 being the dominant domain for apoCaM interaction (XREF_FIG)."
TEA affects KCNQ3
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TEA inhibits KCNQ3. 1 / 1
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"As shown in Fig. 2 C, KCNQ2 homomers are sensitive to low doses of TEA, whereas KCNQ3 homomers are only partially blocked by high concentrations of TEA."
REST affects KCNQ3
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REST decreases the amount of KCNQ3. 1 / 1
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trrust
No evidence text available
Kcnq4/5 affects KCNQ3
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Kcnq4/5 activates KCNQ3. 1 / 1
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"This branching pattern can be explained by two duplication events in the vertebrate lineage, where a single proto-orthologue to Kcnq2/3/4/5, duplicated to create two ancestor genes to Kcnq2/3 and Kcnq4/5 which both duplicated again to produce Kcnq2, kcnq3, kcnq4 and kcnq5 genes as conserved in current vertebrate genomes."
Kcnq2/3 affects KCNQ3
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Kcnq2/3 activates KCNQ3. 1 / 1
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"This branching pattern can be explained by two duplication events in the vertebrate lineage, where a single proto-orthologue to Kcnq2/3/4/5, duplicated to create two ancestor genes to Kcnq2/3 and Kcnq4/5 which both duplicated again to produce Kcnq2, kcnq3, kcnq4 and kcnq5 genes as conserved in current vertebrate genomes."
KCNQ3-Delta476-498 mutants affects KCNQ3
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KCNQ3 binds KCNQ3-Delta476-498 mutants. 1 / 1
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"Also, the KCNQ2-I340A and KCNQ3-Delta476-498 mutants strongly interacted with wild-type KCNQ3 and KCNQ2, respectively (Figs. 1 C-D)."
KCNQ3 affects pyraclofos
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"Individually, expression of KCNQ2 or KCNQ3 in Xenopus oocytes elicits voltage gated, rapidly activating K +-selective currents similar to KCNQ1."
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sparser
"M-channels formed by KCNQ2 and KCNQ3 subunits may also have allosteric coupling as suggested by the report that these channels can open even when only the high affinity KCNQ3 subunits are bound to PIP 2 (Telezhkin et al., xref ), suggesting that opening is not concerted as in the linear scheme (Figure xref )."
KCNQ3 affects p.W309R
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Mutated KCNQ3 inhibits p.W309R. 1 / 1
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"Especially, Uehara et al. (2008) verified that p.W309R mutation of KCNQ3 does not impair normal surface expression of the channel, and the position of p.W309R in KCNQ3 is equivalent to that of the p.W276 in KCNQ4 protein [34]."
KCNQ3 affects dopamine
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"Kcnq2 and Kcnq3 have been shown to mediate the release of dopamine after exposure to ethanol."
KCNQ3 affects apoCaM proteins
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KCNQ3 binds apoCaM proteins. 1 / 1
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reach
"Considering a very low level of intracellular Ca 2+ in dissociated hippocampal cultured neurons at rest XREF_BIBR, we propose that apoCaM proteins bind simultaneously to helices A and B of KCNQ2 and KCNQ3 at the ER, with the IQ motif in helix A of KCNQ2 being the dominant domain for apoCaM interaction (XREF_FIG)."
KCNQ3 affects UPR
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KCNQ3 activates UPR. 1 / 1
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"To determine if ER retention of KCNQ3 channels resulted in activation of the UPR, we analyzed transfected samples for upregulation of the molecular chaperone, GRP78."
KCNQ3 affects S4
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KCNQ3 activates S4. 1 / 1
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"Voltage clamp fluorometry reveals that the R230C mutation in KCNQ3 allows S4 movement but shifts the open and closed transition of the gate to very negative potentials."
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reach
"Downregulated genes in MS microglia included synapse remodeling transcript SYNDIG1 and potassium channel KCNQ3."
KCNQ3 affects KCNQ4, KCNQ5, and SRC
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SRC binds KCNQ3, KCNQ4, and KCNQ5. 1 / 1
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sparser
"Immunoprecipitation and immunoblot analysis showed Src-dependent phosphotyrosine signals associated with KCNQ3, KCNQ4, and KCNQ5 but not with KCNQ1 or KCNQ2 that may be tyrosine phosphorylation of the channel subunits."
KCNQ3 affects KCNQ3-Delta476-498 mutants
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KCNQ3 binds KCNQ3-Delta476-498 mutants. 1 / 1
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"Also, the KCNQ2-I340A and KCNQ3-Delta476-498 mutants strongly interacted with wild-type KCNQ3 and KCNQ2, respectively (Figs. 1 C-D)."
KCNQ3 affects K + channel
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KCNQ3 activates K + channel. 1 / 1
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"In our previous microarray analysis XREF_BIBR, among the upregulated channels in the VTA of resilient mice that have therapeutic potential as a drug target, we found KCNQ3 (Kv7.3), a slow voltage activated K + channel XREF_BIBR XREF_BIBR."
KCNQ3 affects IQ
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"We thus propose that apoCaM binds the IQ domain of KCNQ3 with a high-affinity, and coordinates the association of the KCNQ2/3 complex ( Fig. 7 )."
KCNQ3 affects CALM3
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hprd
No evidence text available
KCNQ3 affects CALM2
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hprd
No evidence text available
KCNQ3 affects BFNC2
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KCNQ3 activates BFNC2. 1 / 1
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"Two voltage gated potassium channel subunit genes, KCNQ2 and KCNQ3, have been identified to cause BFNC1 and BFNC2, respectively."
KCNQ3 affects BFNC1
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KCNQ3 activates BFNC1. 1 / 1
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"Two voltage gated potassium channel subunit genes, KCNQ2 and KCNQ3, have been identified to cause BFNC1 and BFNC2, respectively."
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sparser
"Fitting the data for WT and mutant channels to an activation mechanism with independent PI(4,5)P 2 binding to two Kv7.2 and two Kv7.3 subunits suggests that the two components of the M-channel activation curve correspond to the interaction of PI(4,5)P 2 with the Kv7.3 and Kv7.2 subunits, respectively, that channels can open when only the two Kv7.3 subunits have bound DiC 8 -PI(4,5)P 2 , and that maximum channel opening requires binding to all four subunits."
KCNQ1 affects KCNQ3, and STX1A
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"The present study establishes a novel interaction between syntaxin 1A and a specific member of the Kv7 family, KCNQ2, but not KCNQ3 or KCNQ1, which bind syntaxin 1A more weakly ( xref )."
IQ domain affects KCNQ3, and apoCaM
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KCNQ3 binds IQ domain and apoCaM. 1 / 1
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reach
"We thus propose that apoCaM binds the IQ domain of KCNQ3 with a high-affinity, and coordinates the association of the KCNQ2/3 complex."
GS26575 affects KCNQ3
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"In our studies, KCNQ2 and KCNQ3 channels were inhibited by activation of muscarinic m1, m3, and m5 receptors, but not m2 or m4 receptors."
EB affects KCNQ3
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EB decreases the amount of KCNQ3. 1 / 1
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"We found that EB significantly increased the expression of KCNQ5 and Kv4.1 and decreased expression of KCNQ3 and AKAP in the rostral arcuate."
CaM1234 affects KCNQ3
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CaM1234 inhibits KCNQ3. 1 / 1
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"Importantly, coexpression of CaM1234 modestly reduced but did not abolish enrichment of HA-KCNQ3 and KCNQ2 channels at the axonal surface (XREF_FIG), suggesting that KCNQ2 binding to apoCaM but not Ca 2+ -bound CaM is required for targeting the channels to the axonal surface."
CALM3 affects KCNQ3
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hprd
No evidence text available
CALM2 affects KCNQ3
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hprd
No evidence text available
CALM affects KCNQ2, KCNQ3, and cooH
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CALM binds KCNQ2, KCNQ3, and cooH. 1 / 1
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sparser
"Using similar biochemical approaches, both papers demonstrated CaM binding to the intracellular COOH-terminal domains of KCNQ2 and KCNQ3 channels, and disruption of binding by mutagenesis of residues at regions similar to those named IQ 1 and IQ 2 in the present study."
CALM affects KCNQ2, and KCNQ3
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CALM binds KCNQ2 and KCNQ3. 1 / 1
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sparser
"Recent studies have shown that calmodulin (CaM) binds to the KCNQ2 and KCNQ3 C termini and may function as an auxiliary channel subunit xref , xref , xref ."
CA1 affects KCNQ3
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CA1 inhibits KCNQ3. 1 / 1
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"For instance, the potassium channels Kcnq3 and Merg1a were significantly downregulated by approximately 25% in CA1, whereas Dlg1 was significantly upregulated in CA1."
BL-1249 affects KCNQ3
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BL-1249 inhibits KCNQ3. 1 / 1
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"For example, BL-1249 produces significant inhibition of BK (K Ca 1.1), K v 7.2 (KCNQ2), K v 7.3 (KCNQ3) and Na V 1.7 channels at a concentration of 10muM."
BBR affects KCNQ3
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BBR activates KCNQ3. 1 / 1
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"At 10 muM, BBR potentiated KCNQ1, KCNQ4, and KCNQ5 but not KCNQ3."
Akap5 affects KCNQ2, and KCNQ3
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sparser
"The fraction of complexes representing KCNQ2 or KCNQ3 homomers associated with AKAP150 was very low, as was the fraction of KCNQ2/3 heteromers unpaired with AKAP150."
ARAF affects KCNQ2, and KCNQ3
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KCNQ2 binds KCNQ3 and ARAF. 1 / 1
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sparser
"Kv7.2 and Kv7.3 subunits are associated with PKs such as PKC through AKAPs [ xref ]."
APP affects KCNQ3
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APP decreases the amount of KCNQ3. 1 / 1
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"In addition, after 120-minutes Abeta incubation only induced a significant decrease of Kcnq3 subunit expression (XREF_FIG, p = 0.034)."
ANK3 affects KCNQ2, KCNQ3, and voltage-gated potassium channel
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ANK3 binds KCNQ2, KCNQ3, and voltage-gated potassium channel. 1 / 1
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sparser
"In line with this role, ANK3 interacts directly with KCNQ2, which is expressed in the brain and forms homomeric and heteromeric voltage-gated potassium channels with another member of the KCNQ family, KCNQ3."
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"KCNQ2 and KCNQ3 currents can be increased by intracellular cyclic AMP, an effect that depends on an intact phosphorylation site in the KCNQ2 amino terminus."
1A affects KCNQ3, and syntaxin
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KCNQ3 binds 1A and syntaxin. 1 / 1
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"However, because the in vitro binding of KCNQ3 were not significantly different from those of KCNQ2, and KCNQ3 still bound syntaxin 1A in vivo (albeit weakly as compared to KCNQ2), it may well be that the differences in syntaxin 1A functional potencies between KCNQ2 and KCNQ3 may not be due to the differential binding affinities, but rather to differential coupling efficiencies between syntaxin 1A binding domain and the gating and/or conductance machinery."