INDRA statements for KCNQ1

This page allows you to curate the loaded statements. For more information please see the manual.

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
PKA affects KCNQ1
| 1 3 29 34
PKA phosphorylates KCNQ1.
| 1 1 25 33
PKA phosphorylates KCNQ1. 45 / 45
| 1 1 21 23
reach
"17-B estradiol (E2) inhibits Cl - secretion via PKC and PKA dependent phosphorylation of the KCNQ1 : KCNE3 K + channels in colonic crypts and berberine displays a remarkably similar mechanism of antisecretory action to E2 (both inhibit KCNQ1 channels by protein kinase phosphorylation and neither molecule inhibits CFTR)."
21747769
sparser
"β1-AR activation leads to activation of protein kinase A (PKA), which directly phosphorylates the KCNQ1 subunit, increasing I Ks function. xref - xref The increase in I Ks is thought to suppress the premature beats and afterdepolarization induced by increased L-type Ca 2+ currents during β-adrenergic stimulation. xref Accordingly, ß-blockers have been considered the first-line therapy in LQT1 patients without a history of aborted cardiac arrest (ACA)."
22456477
sparser
"β-adrenergic stimulation increases I Ks through PKA phosphorylation of KCNQ1, an event important for reducing action potential duration during states of increased chronotropy."
21600214
sparser
"In IKs/B2-AR myocytes, IKs density was increased, and activation shifted in the hyperpolarizing direction; IKs was not further modulated by exposure to isoproterenol, and KCNQ1 was found to be PKA-phosphorylated."
15272004
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR In the case of LQT11, a mutation within AKAP9, which encodes an A kinase anchoring protein responsible for facilitating phosphorylation of KCNQ1 by protein kinase A, impairs I Ks augmentation, leading to a clinical phenotype similar to that for LQT1 and LQT5."
26425105
sparser
"The AKAP Yotiao, the smallest transcript of the AKAP9 gene, is essential for cardiac repolarization since it mediates the PKA-dependent phosphorylation of KCNQ1 and therefore regulates the activity of the I Ks potassium channel [ xref ]."
29461511
reach
"Specifically, this mutation disrupts the binding between KCNQ1 and Yotiao, reduces PKA phosphorylation of KCNQ1, and eliminates the cAMP induced response of KCNQ1 [XREF_BIBR]."
20689672
sparser
"In conclusion, AC9 is necessary for sympathetic regulation of PKA phosphorylation of KCNQ1 in vivo and for functional regulation of I Ks in adult cardiomyocytes."
31461851
sparser
"The functional effects of PKA phosphorylation of KCNQ1 are demonstrated by a hyperpolarizing shift in the voltage dependence of activation and an increase in the activity of the channel."
12623298
reach
"beta-adrenergic stimulation increases I Ks through PKA phosphorylation of KCNQ1, an event important for reducing action potential duration during states of increased chronotropy."
21600214
sparser
"These results suggest that direct PKA phosphorylation of KCNQ1 is responsible for the PKA modulation of the observed PLC-dependent inhibition."
22787448
reach
"During beta-adrenergic stimulation, 3 '-5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) phosphorylates KCNQ1, producing an increase in I Ks current and a shortening of the action potential."
28687606
reach
"Several studies have shown that KCNQ1 activity is regulated by PKA dependent phosphorylation XREF_BIBR - XREF_BIBR and two studies suggested that the PKA dependent phosphorylation of KCNQ1 increases its interaction with PIP 2 XREF_BIBR, XREF_BIBR."
24681627
reach
"XREF_BIBR Although it has been shown that KCNE1 is not required for PKA phosphorylation of KCNQ1, XREF_BIBR neither the mechanism of the transduction by KCNE1 nor roles of other KCNE variants in the cAMP mediated regulation via the macromolecular complex have been explored."
19077539
sparser
"Amino acid sequence comparison among the KCNE peptides, and KCNE1 truncation experiments, reveal a segment of the predicted intracellular KCNE1 carboxyl terminus (C-T) that is necessary for functional transduction of PKA phosphorylated KCNQ1."
19077539
reach
"The functional effects of PKA phosphorylation of KCNQ1 are demonstrated by a hyperpolarizing shift in the voltage dependence of activation and an increase in the activity of the channel."
12623298
sparser
"During β-adrenergic stimulation, 3′-5′-cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) phosphorylates KCNQ1, producing an increase inI Ks current and a shortening of the action potential."
28687606
reach
"Human mutations that disrupt I (Ks)-Yotiao interaction result in reduced PKA dependent phosphorylation of the I (Ks) subunit KCNQ1 and inhibition of sympathetic stimulation of I (Ks), which can give rise to long-QT syndrome."
22778270
reach
"Finally, AC9 association with the KCNQ1 and Yotiao complex sensitized PKA phosphorylation of KCNQ1 to beta-adrenergic stimulation."
22778270
sparser
"For example, loss-of-function mutations in the pore-forming α‑subunit Kv7.1, β‑subunit KCNE1 and the AKAP Yotiao have been identified that disrupt the I Ks macromolecular complex and thereby prevent PKA-dependent phosphorylation of Kv7.1 and subsequent upregulation of I Ks during sympathetic stimulation [ xref , xref ]."
29214349
reach
"Co-expression of AC9 and Yotiao in CHO cells stably expressing KCNQ1-KCNE1 sensitize PKA phosphorylation of KCNQ1 in response to isoproterenol compared to AC9 or Yotiao expression alone [XREF_BIBR]."
29367580
sparser
"Several studies have shown that KCNQ1 activity is regulated by PKA-dependent phosphorylation xref – xref and two studies suggested that the PKA-dependent phosphorylation of KCNQ1 increases its interaction with PIP 2 xref , xref ."
24681627
reach
"Beta-adrenergic control of I Ks by PKA phosphorylation of KCNQ1 increases channel current to shorten the action potential and maintain diastolic intervals in response to an increase in heart rate."
29367580
reach
"beta1-AR activation leads to activation of protein kinase A (PKA), which directly phosphorylates the KCNQ1 subunit, increasing I Ks function."
22456477
reach
"In conclusion, AC9 is necessary for sympathetic regulation of PKA phosphorylation of KCNQ1 in vivo and for functional regulation of I Ks in adult cardiomyocytes."
31461851
sparser
"More recently, Lopes et al. ( xref ) showed a crosstalk between KCNQ1 phosphorylation by PKA and its regulation by G-proteins of the Gq/G11 family."
22787448
rlimsp
"Amino acid sequence comparison among the KCNE peptides, and KCNE1 truncation experiments, reveal a segment of the predicted intracellular KCNE1 carboxyl terminus (C-T) that is necessary for functional transduction of PKA phosphorylated KCNQ1."
19077539
sparser
"Specifically, this mutation disrupts the binding between KCNQ1 and Yotiao, reduces PKA phosphorylation of KCNQ1, and eliminates the cAMP-induced response of KCNQ1 [ xref ]."
20689672
sparser
"Specifically, recent findings from Kass and Ackerman have identified AKAP9-S1570L which markedly diminishes the interaction of yotiao with KCNQ1, resulting in reduction in PKA-dependent phosphorylation of Kv7.1, and thus striking inhibition of I KS regulation by cAMP. xref Similar to models of LQT1 - associated mutations in KCNQ1 that block yotiao binding and I KS phospho-regulation, yotiao mutations are also predicted to prolong the action potential and increase arrhythmia susceptibility (now termed type 11 long QT syndrome). xref In support of this notion, the S1570L proband displayed a clinical LQTS phenotypes (now referred to as type 11 long QT syndrome; MIM#611820) similar to LQT1 mutations that block KCNQ1 association with yotiao (female, QT c 485 ms presenting with syncope and family history of LQTS). xref Together, these two related studies have revealed the critical importance of local regulation of ion channels by accessory ChIPs, as well as demonstrate the power of combining clinical genetics and molecular/cellular cardiology to drive disease discovery."
20724725
sparser
"We find cAMP-mediated PKA phosphorylation of KCNQ1 (at residue Ser 27 ) is not affected by its expression with the KCNE variants KCNE1, KCNE2 or KCNE3."
19077539
sparser
"β-adrenergic receptor mediated I Ks upregulation, a functional consequence of PKA phosphorylation of the KCNQ1 amino terminus (N-T), requires co-expression of KCNQ1/Yotiao with KCNE1."
19077539
reach
"beta1-AR activation leads to activation of protein kinase A (PKA), which directly phosphorylates the KCNQ1 subunit, increasing I Ks function."
22456477
sparser
"G269S modestly affected IKs in control conditions, but it almost completely blunted IKs responsiveness in conditions that simulate or mimic PKA phosphorylation of KCNQ1."
24184248
reach
"beta-adrenergic receptor mediated I Ks upregulation, a functional consequence of PKA phosphorylation of the KCNQ1 amino terminus (N-T), requires co-expression of KCNQ1 and Yotiao with KCNE1."
19077539
reach
"PKA phosphorylation of the anchored KCNQ1 channel subunit increases I Ks current and shortens the action potential duration to allow sufficient diastolic intervals upon increased heart rate."
28717248
reach
"During beta-adrenergic stimulation, 3 '-5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) phosphorylates KCNQ1, producing an increase in I Ks current and a shortening of the action potential."
28687606
reach
"AC9 is proposed to regulate PKA phosphorylation of KCNQ1 via its scaffolding to Yotiao 4, however, the interpretation of a bradycardia phenotype is complicated in mice."
28717248
sparser
"The replacement of Ser-43 by Ala ablates the PKA phosphorylation of N-T Yotiao and markedly diminishes the functional response of the wild type and pseudo-phosphorylated I(Ks) channel to cAMP but neither prevents the PKA phosphorylation of KCNQ1 nor its binding to Yotiao."
16002409
reach
"The replacement of Ser 43 by Ala ablates the PKA phosphorylation of N-T Yotiao and markedly diminishes the functional response of the wild type and pseudo phosphorylated I (Ks) channel to cAMP but neither prevents the PKA phosphorylation of KCNQ1 nor its binding to Yotiao."
16002409
sparser
"Co-expression of AC9 and Yotiao in CHO cells stably expressing KCNQ1–KCNE1 sensitize PKA phosphorylation of KCNQ1 in response to isoproterenol compared to AC9 or Yotiao expression alone [ xref ]."
29367580
reach
"The AKAP Yotiao, the smallest transcript of the AKAP9 gene, is essential for cardiac repolarization since it mediates the PKA dependent phosphorylation of KCNQ1 and therefore regulates the activity of the I Ks potassium channel [XREF_BIBR]."
29461511
sparser
"Beta-adrenergic control of I Ks by PKA phosphorylation of KCNQ1 increases channel current to shorten the action potential and maintain diastolic intervals in response to an increase in heart rate."
29367580
sparser
"We propose that the KCNQ1-KCNE1 channel directly interacts with microtubules and that this interaction plays a major role in coupling PKA-dependent phosphorylation of KCNQ1 with I(Ks) activation."
18390900
reach
"Loss of this scaffold decreases cAMP dependent PKA phosphorylation of KCNQ1, eliminates the functional response by I Ks, and prolongs the action potential [XREF_BIBR]."
29367580
reach
"These results suggest that direct PKA phosphorylation of KCNQ1 is responsible for the PKA modulation of the observed PLC dependent inhibition."
22787448
PKA phosphorylates KCNQ1 on S27. 13 / 13
| 4 9
reach
"KCNQ1-KCNE3 complexes do not show the same upregulation in response to PKA phosphorylation of KCNQ1 S27 (Kurokawa et al., 2009)."
26410412
reach
"The primary function of the AKAP9 bound PKA is to phosphorylate the S27 residue on KCNQ1."
21885989
sparser
"β-adrenergic regulation of I Ks is mediated by a macromolecular signaling complex consisting of KCNQ1, KCNE1 and Yotiao (an AKAP) that regulates channel activity by PKA-dependent phosphorylation of Ser 27 in the N-terminal KCNQ1 ( xref ), and of Ser 43 in the N-terminal of Yotiao ( xref , xref )."
23242028
reach
"PKA phosphorylates Ser27 on KCNQ1 to modulate I Ks and phosphorylates Ser43 of Yotiao to further enhance regulation by the sympathetic nervous system, whereas dephosphorylation of these sites and suppression of I Ks currents are facilitated by anchored PP1."
23043438
sparser
"Stimulation of β-adrenergic receptors increases the magnitude of I Ks in the heart via a protein kinase A (PKA)-dependent phosphorylation of Ser-27 of KCNQ1 [83] ."
12623297
sparser
"KCNQ1-KCNE3 complexes do not show the same upregulation in response to PKA phosphorylation of KCNQ1 S27 ( Kurokawa et al., 2009 )."
26410412
sparser
"PKA phosphorylates Ser27 on KCNQ1 to modulate I Ks and phosphorylates Ser43 of Yotiao to further enhance regulation by the sympathetic nervous system, whereas dephosphorylation of these sites and suppression of I Ks currents are facilitated by anchored PP1 ( xref – xref )."
23043438
reach
"Initial studies show that PKA can mediated phosphorylation of KCNQ1 at position Ser27 at its C-terminal tail, which may by counteracted by PP1 and regulated by the accessory protein Yotiao."
26617522
reach
"XREF_BIBR, XREF_BIBR To mimic PKA phosphorylation of KCNQ1, we replaced KCNQ1 Ser 27 by Asp (S27D) to change the charge at this residue and refer to the construct as pseudo phosphorylated KCNQ1 as we have previously reported."
19077539
reach
"beta-adrenergic regulation of I Ks is mediated by a macromolecular signaling complex consisting of KCNQ1, KCNE1 and Yotiao (an AKAP) that regulates channel activity by PKA dependent phosphorylation of Ser 27 in the N-terminal KCNQ1, and of Ser 43 in the N-terminal of Yotiao."
23242028
reach
"KCNQ1-KCNE3 complexes do not show the same upregulation in response to PKA phosphorylation of KCNQ1 S27 59."
26410412
reach
"We find cAMP mediated PKA phosphorylation of KCNQ1 (at residue Ser 27) is not affected by its expression with the KCNE variants KCNE1, KCNE2 or KCNE3."
19077539
reach
"Stimulation of beta-adrenergic receptors increases the magnitude of I Ks in the heart via a protein kinase A (PKA)-dependent phosphorylation of Ser 27 of KCNQ1 [83]."
12623297
PKA phosphorylates KCNQ1 at position 59. 1 / 1
| 1
reach
"KCNQ1-KCNE3 complexes do not show the same upregulation in response to PKA phosphorylation of KCNQ1 S27 59."
26410412
PKA binds KCNQ1.
| 4
PKA binds AKAP9 and KCNQ1. 2 / 2
| 2
sparser
"We have previously shown that adenylyl cyclase Type 9 (AC9) is associated with a KCNQ1-Yotiao-PKA complex and facilitates isoproterenol-stimulated phosphorylation of KCNQ1 in an immortalized cell line."
31461851
sparser
"Molecular mechanistic studies showed that this mutation partially inhibits protein-protein interactions of KCNQ1-AKAP9, leading to decreased PKA-mediated phosphorylation of KCNQ1."
29370121
PKA binds PPP1 and KCNQ1. 1 / 1
| 1
sparser
"With regard to disease processes leading to arrhythmia, it has been recently shown that the β-adrenergic signaling cascade involves the association of PKA and PP1 with the C-terminal domain of KCNQ1[ xref ] (the α-subunit of I Ks )."
20652086
PKA binds PPP1, AKAP9, KCNQ1, and sch1. 1 / 1
| 1
sparser
"Notably, I KS activity is tightly regulated by PKA-dependent phosphorylation, and this phosphorylation is tuned by both local PKA and PP1 signaling cascades. xref In heart, yotiao directly associates with Kv7.1 to recruit both PKA and PP1 to regulate I KS phosphorylation and gating ( xref ). xref Moreover, the LQT1-causative mutation, G589D abolishes Kv7.1’s association with yotiao thereby disrupting the channel’s sensitivity to beta-adrenergic regulation. xref "
20724725
PKA activates KCNQ1.
| 2 1
PKA activates KCNQ1. 1 / 1
| 2 1
reach
"All these results suggest that the KCNQ1 sensitivity to PIP 2 is modulated by PKA."
22787448
KCNQ1 affects Lys-Ser
| 46
KCNQ1 activates Lys-Ser.
| 28
KCNQ1 activates Lys-Ser. 22 / 22
| 22
reach
"The delayed rectifier K + channels K V 7.1 (KCNQ1), which underlies I Ks, and K V 11.1 (ERG), which produces I Kr, are thought to be primarily responsible for repolarization of the sinoatrial AP."
31756134
reach
"The delayed rectifier K + channels K V 7.1 (KCNQ1), which underlies I Ks, and K V 11.1 (ERG), which produces I Kr, are thought to be primarily responsible for repolarization of the sinoatrial AP."
31756134
reach
"Furthermore, while the I Ks current suppressing effect is mediated by KCNQ1, the voltage-shift effect requires the presence of KCNE1, because JPH-2 does not shift the activation curve of KCNQ1 expressed alone."
26538326
reach
"Under basal conditions, only a small portion of KCNQ1 reaches the cell surface to support the I Ks function."
28611207
reach
"This hypothesis was confirmed by us [61] and others [60] when heterologous expression of KCNQ1 subunits with minK subunits in mammalian cells was shown to induce I Ks."
12623297
reach
"The overexpression of miR-1/133 suppressed KCNE1 and KCNQ1, which both encode the slow delayed rectifier potassium current (I Ks), playing a key role in restoring the functional I Ks, which is reduced by the inhibition of KCNE1 and KCNQ1 in diabetic conditions [XREF_BIBR]."
28299324
reach
"As shown in Figure 3A, coexpression of KCNQ1 -WT (0.5 mug) with KCNE1 (0.5 mug) produced a slowly activating outward WT-I Ks on depolarization to 30 mV from the holding potential of -80 mV."
24096004
reach
"Given potential variability between experiments, controls were assessed during the time of each experimental group and the ratio of KCNQ1 to KCNE1 was standardized to produce classical characteristics of I Ks."
29410121
reach
"It was subsequently shown that a complex of the KCNQ1 pore forming subunit with KCNE1 underlies I Ks."
27702655
reach
"beta1-AR activation leads to activation of protein kinase A (PKA), which directly phosphorylates the KCNQ1 subunit, increasing I Ks function."
22456477
reach
"It is well known that the congenital dysfunction of I Ks caused by genetic mutations in the KCNQ1 or KCNE1 gene is linked to congenital long QT syndrome subtype LQT1 or LQT5 [XREF_BIBR]."
23118556
reach
"Furthermore, they showed that this was due to their ability to regulate the expression of two potassium channel proteins, KCNE1 (P15382) and KCNQ1 (P51787), which mediate I Ks."
29440116
reach
"The founder of this family, KCNE1, also known as MinK (minimal K + channel protein), or IsK, was first found to co-assemble with the Kv alpha subunit Kv7.1 (KCNQ1) to form the slowly activating cardiac ventricular repolarization current I Ks."
22754540
reach
"Mutations in the KCNQ1 and HERG genes cause the Long QT Syndromes, LQTS1 and LQTS2, due to reductions in the cardiac repolarizing I Ks and I Kr currents, respectively."
20348026
reach
"These results show that Ca 2+, CaM, or binding of Ca 2+ / CaM complex to the C terminus of KCNQ1 is required to activate I Ks."
25234465
reach
"Mutations in KCNQ1 can cause dysfunction in the I Ks channel, such as a delay in channel opening or a reduction in the duration for which it is open XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
27761162
reach
"Clinical Perspectives Long QT syndrome type 1 (LQT1) is caused by mutations in the KCNQ1 gene resulting in a decrease in the repolarizing potassium current I Ks."
26318259
reach
"Furthermore, they showed that this was because of their ability to regulate the expression of 2 potassium channel proteins, KCNE1 (P15382) and KCNQ1 (P51787), which mediate I Ks."
29440116
reach
"4,16,19-21 Chen et al 4 first reported the KCNQ1 -S140G mutation that potentiated I Ks, especially the component of instantaneous activation."
24096004
reach
"PKA phosphorylates Ser27 on KCNQ1 to modulate I Ks and phosphorylates Ser43 of Yotiao to further enhance regulation by the sympathetic nervous system, whereas dephosphorylation of these sites and suppression of I Ks currents are facilitated by anchored PP1."
23043438
reach
"The coassembly of KCNQ1 and KCNE1 produces the I KS potassium current that is critical for the late repolarization of the cardiac action potential."
15226366
reach
"The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium current, I Ks, that responds to sympathetic stimulation and is critical for human cardiac repolarization."
31461851
KCNQ1-V141M activates Lys-Ser. 1 / 1
| 1
reach
"The heterozygous V141M KCNQ1 expression caused slower deactivation for I Ks."
29213224
Mutated KCNQ1 activates Lys-Ser. 1 / 1
| 1
reach
"In long QT syndrome 1, which is also caused by KCNQ1 mutation affecting I Ks, a greater reactivity of the sympathetic control of the QT interval has been recognized as a protective factor [XREF_BIBR]."
29213224
KCNQ1 bound to KCNE1 activates Lys-Ser. 1 / 1
| 1
reach
"KCNQ1 and KCNE1 are endogenously coexpressed in heart and inner ear, and formation of a KCNQ1 and KCNE1 complex underlies the slow activation of the delayed rectifier current I Ks."
17698596
KCNQ1-L203P activates Lys-Ser. 1 / 1
| 1
reach
"A novel allelic variant of KCNQ1 (L203P) was identified and characterized, causing a dominant negative effect on I Ks."
21459285
KCNQ1-G229D activates Lys-Ser. 1 / 1
| 1
reach
"In contrast, transfection of KCNQ1- G229D (0.5 mug), coexpressed with equimolar KCNE1, produced an instantaneously activated G229D-I Ks that did not deactivate after repolarization to -50 mV."
24096004
KCNQ1-V241F activates Lys-Ser. 1 / 1
| 1
reach
"(ii) The V241F KCNQ1 mutation sustained re-entry, produce more persistent wavelets in a limited size of tissue, and led to more frequent atrial excitation in the 2D and 3D model.According to Ki et al. (2013), the V241F KCNQ1 mutation induces an increment of I Ks."
25230101
KCNQ1 inhibits Lys-Ser.
| 16
KCNQ1 inhibits Lys-Ser. 13 / 13
| 13
reach
"An overexpression of miR-1/133 abolished KCNE1 and KCNQ1 expression, thus reducing the I KS with enhanced risk of lethal arrhythmias."
29259974
reach
"Finally, elimination of KCNQ1 slow inactivation by KCNE1 may also better enable I Ks to sustain rapid heart rates without current diminishment."
26410412
reach
"Co-expression of KCNE1 and wild-type KCNQ1 subunits in combination with KCNQ1-P343S subunits reduces I Ks currents by = ~ 60%."
15511625
reach
"The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium current, I Ks, that responds to sympathetic stimulation and is critical for human cardiac repolarization."
31461851
reach
"In addition to inducing I Ks dysfunction through dominant negative loss-of-function effects and defective channel trafficking, mutations in KCNQ1 suppress I Ks channel function by reducing the channel affinity of interacting proteins XREF_BIBR, XREF_BIBR."
27761162
reach
"As shown in Figure 3A, coexpression of KCNQ1 -WT (0.5 mug) with KCNE1 (0.5 mug) produced a slowly activating outward WT-I Ks on depolarization to 30 mV from the holding potential of -80 mV."
24096004
reach
"Finally, elimination of KCNQ1 slow inactivation by KCNE1 may also better enable I Ks to sustain rapid heart rates without current diminishment.The non inactivating status endowed by KCNE1 may also facilitate the established function of KCNQ1-KCNE1 in the inner ear."
26410412
reach
"The founder of this family, KCNE1, also known as MinK (minimal K + channel protein), or IsK, was first found to co-assemble with the Kv alpha subunit Kv7.1 (KCNQ1) to form the slowly activating cardiac ventricular repolarization current I Ks."
22754540
reach
"Pathogenic variations in KCNQ1 reduce I Ks, prolonging the repolarization phase of the AP [XREF_BIBR, XREF_BIBR]."
28146053
reach
"LQT1 related mutations in KCNQ1 can impair the I Ks channel function by a number of mechanisms : (a) trafficking defects, (b) lower PIP 2 binding affinity, (c) reduced responsiveness to beta-adrenergic stimulation, and (d) gating kinetic defects."
25460172
reach
"Heterologous expression studies demonstrated that mutations in KVLQT1 reduce I (Ks) by causing loss of channel function, altered channel gating, and/or a dominant negative effect."
10868746
reach
"In summary, in response to sustained beta-AR stimulation, CaMKII phosphorylates KCNQ1 at S484 to inhibit I Ks function."
29410121
reach
"For example, LQTS type I is caused by loss of function mutations in KvLQT1 that reduce the I Ks during AP repolarization."
26009542
KCNQ1-P320A inhibits Lys-Ser. 1 / 1
| 1
reach
"In the presence of KCNE1 subunits, however, mutant KCNQ1 P320H or P320A subunits suppressed I Ks in a dominant negative manner to 18% (KCNQ1 P320H) and 22% (KCNQ1 P320A), respectively."
19540844
KCNQ1-P320H inhibits Lys-Ser. 1 / 1
| 1
reach
"In the presence of KCNE1 subunits, however, mutant KCNQ1 P320H or P320A subunits suppressed I Ks in a dominant negative manner to 18% (KCNQ1 P320H) and 22% (KCNQ1 P320A), respectively."
19540844
KCNQ1-R174C inhibits Lys-Ser. 1 / 1
| 1
reach
"Compared with WT, WT + R174C KCNQ1 significantly decreased I Ks densities for voltages between -30 mV and +30 mV."
29449639
KCNQ1 decreases the amount of Lys-Ser.
| 2
Mutated KCNQ1 decreases the amount of Lys-Ser. 1 / 1
| 1
reach
"The above studies suggest that loss-of-function in I Ks caused by KCNQ1 mutation not only can predispose patients to congenital LQT1, but can be also associated with acquired LQT1."
27761162
Modified KCNQ1 decreases the amount of Lys-Ser. 1 / 1
| 1
reach
"Incubation of KCNQ1 expressing oocytes with cycloheximide did not prevent I Ks expression following prKCNE1 injection."
20139709
MINK1 affects KCNQ1
| 1 42
MINK1 binds KCNQ1.
| 1 17
MINK1 binds KCNQ1. 18 / 18
| 1 17
reach
"Thus, KVLQT1 interacts with minK to form the cardiac slowly activating, delayed rectifier I Ks current."
9791861
reach
"10 Thus, minK interacts with both KCNQ1 and HERG, and KCNE1-3 proteins interact with Kv3.1 and Kv3.2 causing diversification of channel gating."
18313602
reach
"Gating of the delayed rectifier K+ channel KvLQT1 is drastically slowed by the association with the small membrane protein minK and it is thought that the KvLQT1 and minK complex underlies the slow delayed rectifier K+ current of cardiac cells."
9817805
reach
"While MinK and KvLQT1 complexes recreate the behaviors of I Ks channels, MiRP1 and HERG complexes recapitulate those of I Kr channels."
10219239
reach
"These efforts have left many unanswered questions regarding how MinK interacts with KvLQT1."
10962015
reach
"Finally, for modulation to occur, MinK must presumably associate with KvLQT1, but it was previously unknown whether this involves the same or different structures responsible for the gating and current amplitude effects."
10962015
reach
"KvLQT1 and minK associate to form the functional slowly activated delayed rectifier potassium channel (I Ks) [12,13] while HERG and MiRP1 associate to form the rapidly activated delayed rectifier potassium channel (I Kr) [10]."
12051962
reach
"There is controversy about the effects of the association between KvLQT1 and minK on the single-channel conductance."
9817805
reach
"This article reviews some of the recent work addressing the prototypical KCNE-channel interaction between minK and KvLQT1."
12069759
reach
"Here we show that the KCNQ1 and minK interaction is influenced by the expression system."
11680622
reach
"Understanding how MinK associates with KvLQT1 and identifying subregions involved in gating modulation may provide insight into the mechanism by which MinK modulates KvLQT1."
10962015
reach
"These results suggested that SCN5A mutations act through a gain-of-function mechanism (the mutant channel functions normally, but with altered properties) and that the mechanism of chromosome-3-linked LQT is the persistent non inactivated Na + current in the plateau phase of the cardiac action potential.Recent physiological studies suggest that minK interacts with KVLQT1 to form the slowly activating, delayed rectifier K + channel (I Ks)."
9791861
reach
"The presence and co-assembly of KvLQT1 and MinK in mouse brain (XREF_FIG) suggests that the protein may modulate neuronal excitability as a KvLQT1 and MinK complex as I KS does in heart."
20368164
reach
"It is already known, for example, that minK can interact with KVLQT1 and HERG when overexpressed in heterologeous systems (McDonald et al., 1997)."
11239413
sparser
"A second current in this type is the, I Ks component mediated by heteromeric channel formed by Kv7.1 and MINK subunit protein that are encoded by KCNQ1 and KCNE1 genes, respectively."
25185978
reach
"8,9 The minK and KvLQT1 complex channel is responsible for the slowly activating component of the delayed rectifier K + channel (I Ks channel), and I Ks is important for the repolarization of cardiac myocytes."
11697903
reach
"Because KvLQT1 subunits give rise to functional potassium channels when expressed alone, it is interesting to consider the nature of the interaction between minK and KvLQT1 that produces larger and more slowly activating currents when these genes are coexpressed."
9834139
reach
"To modulate gating and current amplitude, MinK presumably must associate with KvLQT1 in a specific manner."
10962015
MINK1 activates KCNQ1.
| 18
MINK1 activates KCNQ1. 18 / 18
| 18
reach
"MinK, a 129 amino acid protein containing one transmembrane spanning domain modulates KvLQT1, greatly slowing activation, increasing current amplitude, and removing inactivation."
10962015
reach
"Previous data suggests that the ability of MinK to modulate KvLQT1 resides in amino acid residues 67-93 (Takumi et al. 1991; Ben-Efraim et al. 1996)."
10962015
reach
"To determine whether the MinK COOH terminus alone is sufficient to modulate KvLQT1, a chimera encoding the beta1 NH 2 terminus and transmembrane domain (amino acid residues 1-182) fused to the MinK COOH terminus (amino acid residues 67-129, beta1 and MinK1) was coexpressed in Xenopus oocytes with KvLQT1."
10962015
reach
"In particular, we and others found that F340 is required for MinK modulation of KCNQ1 activation via MinK T58, and that an F340W mutation uncouples MinK-KCNQ1 (I Ks) channel activation from voltage, forming a constitutively open channel (41-43)."
18567635
reach
"This conclusion supports the idea that two MinK subregions mediate association and modulation of KvLQT1."
10962015
reach
"MinK also modulates KvLQT1 current amplitude by an unknown mechanism that may or may not be dependent on gating."
10962015
reach
"A MinK and MiRP1 Chimera Modulates KvLQT1."
10962015
reach
"MinK dramatically modulates KvLQT1 gating, slowing activation (XREF_FIG A, right), removing inactivation (B, right), and shifting the voltage dependence of activation to more positive potentials (D)."
10962015
reach
"These studies indicate that, as in KVLQT1, mutations in minK can cause both autosomal dominant (Romano-Ward syndrome) and autosomal-recessive (JLN) LQT.Identification of SCN5A, HERG, KVLQT1 and minK as LQT genes has led to the identification of three critical electrical currents involved in the cardiac action potential."
9791861
reach
"MinK modulates KvLQT1 gating by slowing activation and removing inactivation."
10962015
reach
"Our experiments using MinK and beta1 chimeras lacking a complete MinK transmembrane domain demonstrate that the MinK COOH terminus does not modulate KvLQT1 in the absence of the MinK transmembrane domain, even though the subdomains reach the plasma membrane."
10962015
reach
"In addition, a mutation in the MinK transmembrane domain associated with long QT syndrome has been found to alter MinK mediated KvLQT1 gating modulation (see below)."
10962015
reach
"Despite the fact that MinK increases KCNQ1 unitary and macroscopic conductance ~ 4-fold, MinK knockout increased I K current in atrial myocytes; interestingly, this was not exclusively due to upregulation of currents sensitive to chromanol 293, a KCNQ1 and I Ks blocker."
19219384
reach
"Further, the formation of MinK-Kv2.1 complexes in vivo could explain the recent findings that kcne1 null mice exhibit atrial fibrillation, and that these mice show increased atrial myocyte I K compared to wild-type, a result inconsistent with effects on I Ks because MinK upregulates KCNQ1 current."
19219384
reach
"Whether MinK mediated KvLQT1 association and modulation involves one or many MinK subregions is unknown."
10962015
reach
"The mechanism by which MinK modulates KvLQT1 gating is currently unknown."
10962015
reach
"Understanding how MinK associates with KvLQT1 and identifying subregions involved in gating modulation may provide insight into the mechanism by which MinK modulates KvLQT1."
10962015
reach
"Based on our previous results that indicate the MinK COOH terminus can modulate KvLQT1 only when an interaction between KvLQT1 and the MinK transmembrane domain occurs, we conclude that MiRP1 does not modulate KvLQT1; in part because of differences in the transmembrane domain that mediate KvLQT1 association."
10962015
MINK1 inhibits KCNQ1.
| 6
MINK1 inhibits KCNQ1. 6 / 6
| 6
reach
"In the same study, CHO cell expression experiments showed that MinK prevented modulation of KCNQ1 by MiRP1, but that MiRPs 2-4 could override effects of MinK on KCNQ1-thus KCNQ1 may be modulated by multiple MiRPs in human heart depending on sub-tissue or even subcellular distribution and other temporal or regulatory factors."
19219384
reach
"A MinK deletion mutant with amino acids 94-129 deleted was able to slow KvLQT1 activation, shift the voltage dependence of activation to more positive potentials, and remove inactivation."
10962015
reach
"The MinK ancillary subunit slows KCNQ1 activation, eliminates its inactivation, and increases its unitary conductance."
19202166
reach
"Further, the F340W mutation alters the effects of MinK on KCNQ1 on both activation and inactivation : MinK increases inactivation and constitutive activation of F340W-KCNQ1, whereas MinK removes inactivation and positively shifts and slows activation of wild-type KCNQ1 (34)."
18567635
reach
"Upon depolarization, MinK Delta79-129 slowed KvLQT1 activation to a lesser extent than wild-type MinK (XREF_FIG A, right center)."
10962015
reach
"MinK eliminates inactivation of wild-type KCNQ1 channels, in contrast to our observations for F340W-I Ks channels (33,34)."
18567635
MINK1 increases the amount of KCNQ1.
| 1
MINK1 increases the amount of KCNQ1. 1 / 1
| 1
reach
"This result also supports the hypothesis that volatile anesthetics have direct effects on membrane proteins, because it has been suggested that minK not only increases the expression of KvLQT1 (Romey et al., 1997) but also associates with a part of the pore region of KvLQT1 channels (Kaczmarek and Blumenthal, 1997)."
12616988
CALM affects KCNQ1
| 1 30 12
CALM binds KCNQ1.
| 1 29 10
CALM binds KCNQ1. 35 / 35
| 1 25 10
sparser
"Thus, the interaction of calmodulin and Kv7.1 appears to be critical for expression and function of I Ks , with the intriguing possibility that regulatory mechanisms could also involve some form of CaMKII interaction with calmodulin and Kv7.1 or KCNE1."
24600393
sparser
"The proximal Kv7.1 C-terminus binds calmodulin (CaM) and phosphatidylinositol-4,5-bisphosphate (PIP 2 ) and recently we revealed the competition of PIP 2 with the calcified CaM N-lobe to a previously unidentified site in Kv7.1 helix B, also known to harbor a LQT mutation."
28976808
sparser
"Disruption of CaM interactions with Kv7.1 ( Ghosh et al., 2006; Shamgar et al., 2006 ), Kv7.2 ( Etxeberria et al., 2008 ), and the Kv7.2/Kv7.3 heteromer ( Liu and Devaux, 2014 ) by disease mutations has indicated that CaM-Kv7 complex formation is important for channel assembly and trafficking and, together with other studies, support the idea that CaM is an auxiliary subunit ( Etxeberria et al., 2008; Gamper et al., 2005; Gamper and Shapiro, 2003; Ghosh et al., 2006; Levitan, 2006; Shamgar et al., 2006; Wen and Levitan, 2002; Yus-Najera et al., 2002 )."
29429937
sparser
"Earlier reports of constitutive association of the Ca 2+ -binding protein calmodulin (CaM) with the C-terminus of KCNQ1 (Yus-Najera et al., xref ; Ghosh et al., xref ; Shamgar et al., xref ; Ciampa et al., xref ) prompted us to consider intracellular Ca 2+ as a putative ligand for KCNQ1-CaM complex."
22866036
reach
"This study describes one physiological form of KCNQ1, depolarized voltage sensors with a closed pore in the absence of PIP 2, and reveals a regulatory interaction between CaM and KCNQ1 that may explain CaM mediated LQTS."
28575668
sparser
"Mutation in the CaM-binding motifs of KCNQ1 [29] is associated with LQTS."
26164367
sparser
"Helix A (residues 370–386) and helix B (residues 504–531) mediate binding of KCNQ1 with CaM, which is required for normal KCNQ1 channel gating, folding and membrane trafficking [9–11] ."
24713462
reach
"To test whether CaM binding to KCNQ1 was dissociated by PIs, we fused each of the two C-terminal KCNQ1 CaM binding regions (CBS1 and CBS2) to MBP and performed competition assays."
17317623
sparser
"This disturbed calmodulin- Kv7.1 interaction may be important for channel expression."
24600393
sparser
"Other mutations that affect PIP 2 or CaM binding to KCNQ1 underlie certain forms of the long QT syndrome and can result in sudden cardiac death ( Park et al., 2005; Ghosh et al., 2006; Shamgar et al., 2006 )."
17317623
sparser
"Formation of functional tetramers requires CaM interaction with the KCNQ1 C-terminus."
16556866
reach
"Earlier reports of constitutive association of the Ca 2+ -binding protein calmodulin (CaM) with the C-terminus of KCNQ1 prompted us to consider intracellular Ca 2+ as a putative ligand for KCNQ1 and CaM complex."
22866036
sparser
"A recent cryo-EM study showed that each Kv7.1 subunit associates with one calmodulin molecule [ xref ]."
29451064
sparser
"Interestingly, co-immunoprecipitation experiments in yeast cells expressing wild-type Kv7.1 or mutated Kv7.1 with truncated α-helices showed that calmodulin can bind to the C-terminus of Kv7.1 ( xref )."
24600393
sparser
"These studies were motivated by the observed similarities between the suppression of KCNQ1 function by pharmacological disruption of KCNQ1-CaM interactions and the effects of KCNE4 co-expression on the channel."
21118809
reach
"Other mutations that affect PIP 2 or CaM binding to KCNQ1 underlie certain forms of the long QT syndrome and can result in sudden cardiac death (Park et al., 2005; Ghosh et al., 2006; Shamgar et al., 2006)."
17317623
sparser
"Functional and biochemical analysis of LQTS mutations in the KCNQ1 C-terminus showed that disruption of CaM interaction with KCNQ1 interfered with subunit assembly and that the resultant channels generated very small currents."
19333131
reach
"The recently published cryo-EM structure of the KCNQ1 and CaM complex [12] falls within the conformational space of possible structures in the library."
30292722
sparser
"Functionally, IKs is regulated by a number of interacting proteins and post‐translational modifications. xref – xref The IKs currents and the channel subunits KCNQ1 and KCNE1 proteins are regulated by the β‐adrenergic‐mediated protein kinase A– dependent phosphorylation, a process that might be pathogenic in heart failure. xref , xref – xref Likewise, IKs are calcium‐responsive currents, partly because of interaction of the KCNQ1 with calmodulin, which is a constitutive component of the K + channels. xref One might speculate that altered interactions of KCNQ1 and calmodulin, in the presence of KCNQ1 mutations, could perturb intracellular calcium homeostasis and affect the contractile performance of cardiac myocytes."
25616976
sparser
"In addition, the CaM- Kv7.1 interaction may also be relevant for the regulation of I Ks gating."
24600393
sparser
"The structural data presented here, namely the Kv7.1 proximal C terminus bound to CaM, provide us with a near atomic resolution picture of this module."
25441029
reach
"Functional and biochemical analysis of LQTS mutations in the KCNQ1 C-terminus showed that disruption of CaM interaction with KCNQ1 interfered with subunit assembly and that the resultant channels generated very small currents."
19333131
reach
"Helix A (residues 370-386) and helix B (residues 504-531) mediate binding of KCNQ1 with CaM, which is required for normal KCNQ1 channel gating, folding and membrane trafficking [9-11]."
24713462
reach
"Cryo-EM Structure of a KCNQ1 and CaM Complex Reveals Insights into Congenital Long QT Syndrome."
28575668
sparser
"Our data indicate that in healthy individuals, CaM binding to KCNQ1 is essential for correct channel folding and assembly and for conferring Ca(2+)-sensitive IKS-current stimulation, which increases the cardiac repolarization reserve and hence prevents the risk of ventricular arrhythmias."
16556865
sparser
"To test if the mutant M520R disrupts channel function by impairing the interaction of Kv7.1 with CaM, we performed yeast two-hybrid experiments ( Fig. 4 B)."
17482572
sparser
"This study describes one physiological form of KCNQ1, depolarized voltage sensors with a closed pore in the absence of PIP 2 , and reveals a regulatory interaction between CaM and KCNQ1 that may explain CaM-mediated LQTS."
28575668
sparser
"Therefore, we considered the M520R mutation to affect the CaM-Kv7.1 interaction."
17482572
sparser
"A redox motif flanking Cys(445) and the interaction of KCNQ1 with calmodulin are required for preferential S-nitrosylation of Cys(445)."
19124472
reach
"Our data indicate that in healthy individuals, CaM binding to KCNQ1 is essential for correct channel folding and assembly and for conferring Ca (2+)-sensitive IKS-current stimulation, which increases the cardiac repolarization reserve and hence prevents the risk of ventricular arrhythmias."
16556865
sparser
"Relevant to this question, CaM’s binding target can affect CaM’s affinity for Ca 2+ , so that it is possible that when CaM associates with the Kv7.1 proximal C terminus, CaM N lobe Ca 2+ affinity increases dramatically ( Olwin and Storm, 1985; Zhang et al., 2012 )."
25441029
reach
"One possibility is that Ca 2+ binding to KCNQ1 bound calmodulin exerts conformational effects that can be transmitted to co-assembled SMITs to Ca 2+ -dependently regulate myo-inositol intake."
28718502
sparser
"Together, these data support the idea that Apo/CaM:Kv7.4 interactions are essential for proper trafficking and are reminiscent of effects reported for mutations that disrupt the interaction between CaM and Kv7.1 ( Ghosh et al., 2006; Shamgar et al., 2006 ), Kv7.2 ( Etxeberria et al., 2008 ), and the Kv7.2/Kv7.3 heteromeric channel ( Liu and Devaux, 2014 )."
29429937
sparser
"To test whether CaM binding to KCNQ1 was dissociated by PIs, we fused each of the two C-terminal KCNQ1 CaM-binding regions (CBS1 and CBS2) to MBP and performed competition assays."
17317623
sparser
"Indeed, structural comparison with the Apo/CaM:Kv7.4 AB domain complex shows that despite the differences in EF4, which is ion bound in the CaM:Kv7.1 complex but empty in the Apo/CaM Kv7.4 complex, both EF3s have similar conformations ( Figure 8 A)."
29429937
CALM binds KCNQ1 and KCNQ2. 1 / 1
| 1
sparser
"WT and mutant Kv7.1 C-termini and Kv7.2 C-terminus did interact with CaM as assayed by HIS3 induction in the GAL4 based yeast two-hybrid system ( Fig. 4 B) while the negative controls did not produce any signal."
17482572
CALM binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"KCNE1 forms a ternary complex with wild-type KCNQ1 and Ca(2+)-CaM that prevents inactivation, facilitates channel assembly, and mediates a Ca(2+)-sensitive increase of IKS-current, with a considerable Ca(2+)-dependent left-shift of the voltage-dependence of activation."
16556865
CALM binds AOPEP and KCNQ1. 1 / 1
| 1
sparser
"Yeast two-hybrid assay also suggests that KCNQ1 associates with apo-CaM."
19333131
CALM binds CAMK2_complex, KCNE1, and KCNQ1. 1 / 1
| 1
sparser
"Thus, the interaction of calmodulin and Kv7.1 appears to be critical for expression and function of I Ks , with the intriguing possibility that regulatory mechanisms could also involve some form of CaMKII interaction with calmodulin and Kv7.1 or KCNE1."
24600393
CALM inhibits KCNQ1.
| 1 2
CALM inhibits KCNQ1. 3 / 3
| 1 2
reach
"Moreover, overexpression of CaM reduced current amplitudes of KCNQ2, KCNQ4, and KCNQ5, but not those of KCNQ1 and KCNQ3."
23087646
reach
"Coexpression of CaM in Chinese hamster ovary (CHO) cells strongly reduced currents of KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3."
15901836
sparser
"The slowly activating potassium current IKs was shown to be increased by elevation of Ca i , as due to a relief of KCNQ1 inactivation by calmodulin in a Ca 2+ dependent way (Ghosh et al., xref )."
24098284
KCNQ1 affects potassium(1+)
| 40
KCNQ1 activates potassium(1+).
| 27
KCNQ1 activates potassium(1+). 23 / 23
| 23
reach
"KCNQ1 contributes to a potassium current that terminates the cardiac action potential."
30461122
reach
"KCNE1, also known as MinK, is one of the five members of the KCNE family that modulate the voltage gated potassium channel alpha subunit KCNQ1 to generate slowly activating potassium currents [XREF_BIBR, XREF_BIBR]."
28233402
reach
"Kcnq1 contributes to an adrenergic sensitive steady-state K+ current in mouse heart."
17597584
reach
"Coexpression of KvLQT1 in association with the channel regulator protein IsK produces a K+ current with characteristics reminiscent of the slow component of the delayed rectifier in cardiac myocytes."
9396783
reach
"Previous studies have shown that genetic deletion of either the pore forming, KCNQ1, or regulatory, KCNE1, subunit of the large conductance, Ca 2+ - and voltage activated potassium (BK) channel produces hyperaldosteronism in mice XREF_BIBR, XREF_BIBR."
27432863
reach
"In conclusion, KCNQ1 coassembles with KCNE2 to form acid activated luminal K+ channels of parietal cells."
15579540
reach
"Expression of KvLQT1 subunits produces small, rapidly activating potassium currents; coexpression of these with minK results in slowly activating I Ks currents that are several-fold larger."
9834139
reach
"The present study was designed to investigate the functional significance of KCNQ1 mediated K+ secretory fluxes in proximal tubular cells of the frog kidney."
17869561
reach
"In addition to I to, f and I Kur, human atrial myocytes also exhibit a rapidly activating and inactivating current (I Kr) and a slowly activating current (I Ks), mediated by hERG1 and KCNQ1 channels, respectively, but they are much smaller outward potassium currents relative to I to, f and I Kur [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
26162324
reach
"KvLQT1 gene product is associated with the regulator protein IsK to produce a component of the delayed rectifier K+ current in cardiac myocytes."
9506986
reach
"Kcne1, Kcnq1, and Kcnq4 encode subunits of inward rectifier voltage activated potassium channels."
23044516
reach
"KCNQ1 and minK channels probably mediate the secretion of potassium into the endolymph that bathes the apical surface of the hair cells that convert mechanical stimulation into electrical signals."
10025409
reach
"Gastric acid secretion can be strongly inhibited by application of the KCNQ1 blocker chromanol 293B, thereby inhibiting potassium efflux and maintaining a hyperpolarized parietal cell by way of intracellular potassium accumulation."
27098917
reach
"Expression of both human and rat KCNQ1 induced time dependent K+ currents that were sensitive to Ba2+ and 293B."
11426298
reach
"Phosphorylation of KCNQ1 is crucial for slow activating delayed potassium current (I Ks)."
29370121
reach
"The coassembly of KCNQ1 and KCNE1 produces the I KS potassium current that is critical for the late repolarization of the cardiac action potential."
15226366
reach
"14 While the current study can not improve upon the numerical KCNQ1 " threshold " required for hearing preservation, it is clear from this study and others that the complete cessation of KCNQ1 mediated K+ secretion in the inner ear linked to the bi-allelic inheritance of two truncating and haploinsufficient mutations is the primary mechanism that disrupts cochlear fluid homeostasis resulting in the collapse of endolymphatic compartment and sensorineural deafness in JLNS patients and murine JLNS models."
23392653
reach
"The present study explored the influence of KCNQ1 on insulin induced cellular K+ uptake and glucose metabolism."
19369585
reach
"KCNE1 is known to modulate the voltage gated potassium channel alpha subunit KCNQ1 to generate slowly activating potassium currents."
28233402
reach
"By contrast, heterologous expression of KVLQT1 and minK together led to a large potassium current with the biophysical properties of cardiac I Ks."
11239413
reach
"This process also requires a constitutive active potassium channel consisting of the KCNQ1 and KCNE2 subunits promoting potassium efflux [XREF_BIBR - XREF_BIBR]."
25009573
reach
"As seen in Fig. 1 a, a similar biphasicity is also present in a high Na + solution, where the tail currents are in the outward direction, supporting the idea that it is a distinguishing feature of the potassium selective conductance induced by expression of KvLQT1 channels."
9675180
reach
"There is no enhancement of the potassium currents mediated by the KCNQ1 channel subunit, which is found primarily in cardiac tissue XREF_BIBR and also in the gastrointestinal system and brain."
22888276
KCNQ1-S277L activates potassium(1+). 1 / 1
| 1
reach
"Electrophysiological characterisation revealed that KCNQ1 S277L subunits did not produce functional potassium channels and suppressed WT KCNQ1 in dominant negative manner in the presence and in the absence of KCNE1."
21241800
KCNQ1 bound to ISK activates potassium(1+). 1 / 1
| 1
reach
"Also, activation of the G-protein-coupled receptor, P2Y4, triggers PKC induced phosphorylation of the IsK (KCNE) auxiliary subunit, thereby inhibiting activity of the KCNQ1 and ISK complex that enables potassium entry into the endolymph."
21909974
KCNQ1 bound to MINK1 activates potassium(1+). 1 / 1
| 1
reach
"Gating of the delayed rectifier K+ channel KvLQT1 is drastically slowed by the association with the small membrane protein minK and it is thought that the KvLQT1 and minK complex underlies the slow delayed rectifier K+ current of cardiac cells."
9817805
KCNQ1-P320H activates potassium(1+). 1 / 1
| 1
reach
"Electrophysiological characterisation revealed that KCNQ1 P320H subunits do not produce functional potassium currents."
19540844
KCNQ1 inhibits potassium(1+).
| 12
KCNQ1 inhibits potassium(1+). 7 / 7
| 7
reach
"Cardiac repolarization is mainly dependent upon rapid and slow delayed-rectifier potassium currents mediated by human ether-a-go-go-related (hERG) gene and the KCNQ1 gene, respectively."
29370121
reach
"KCNE1, also known as MinK, is one of the five members of the KCNE family that modulate the voltage gated potassium channel alpha subunit KCNQ1 to generate slowly activating potassium currents [XREF_BIBR, XREF_BIBR]."
28233402
reach
"KCNE1 is known to modulate the voltage gated potassium channel alpha subunit KCNQ1 to generate slowly activating potassium currents."
28233402
reach
"KvLQT1 and HERG mutations (one each) reduced K+ currents in vitro, consistent with the idea that they augment risk for aLQTS."
11997281
reach
"Clinical Perspectives Long QT syndrome type 1 (LQT1) is caused by mutations in the KCNQ1 gene resulting in a decrease in the repolarizing potassium current I Ks."
26318259
reach
"Kcnq1 impairs insulin secretion by enhancing the beta-cell potassium currents."
28343791
reach
"Long QT syndrome type 1 (LQT1) is caused by mutations in the KCNQ1 gene resulting in a decrease in the repolarizing potassium current slow delayed rectifier current (I Ks)."
26318259
KCNQ1 bound to ISK inhibits potassium(1+). 1 / 1
| 1
reach
"Also, activation of the G-protein-coupled receptor, P2Y4, triggers PKC induced phosphorylation of the IsK (KCNE) auxiliary subunit, thereby inhibiting activity of the KCNQ1 and ISK complex that enables potassium entry into the endolymph."
21909974
KCNQ1-K318I inhibits potassium(1+). 1 / 1
| 1
reach
"Finally, K318I, V319Y KCNQ1 subunits are judged to decrease single-channel potassium flux by noise-variance analysis."
12770875
KCNQ1-V141M inhibits potassium(1+). 1 / 1
| 1
reach
"The mutation V141M KCNQ1 causes a gain-of-function of the slow delayed rectifier potassium current (I Ks) and is one of the mutations that give rise to SQT2 [XREF_BIBR, XREF_BIBR]."
29213224
KCNQ1-S140G inhibits potassium(1+). 1 / 1
| 1
reach
"Functional analysis has shown that the missense gain-in-function KCNQ1 S140G mutation associated with familial atrial fibrillation produces an increase of the slow delayed rectifier potassium current (I (Ks))."
22508963
KCNQ1-V319Y inhibits potassium(1+). 1 / 1
| 1
reach
"Finally, K318I, V319Y KCNQ1 subunits are judged to decrease single-channel potassium flux by noise-variance analysis."
12770875
KCNQ1 phosphorylates potassium(1+).
| 1
KCNQ1 phosphorylates potassium(1+). 1 / 1
| 1
reach
"Finally there are some reports indicating reversible phosphorylation of Sodium and Potassium Channels, e.g., Na V 1.5 and KCNQ1, that are essential for membrane excitation."
26617522
KCNQ1 affects CALM
| 1 29 10
CALM binds KCNQ1. 35 / 35
| 1 25 10
sparser
"Thus, the interaction of calmodulin and Kv7.1 appears to be critical for expression and function of I Ks , with the intriguing possibility that regulatory mechanisms could also involve some form of CaMKII interaction with calmodulin and Kv7.1 or KCNE1."
24600393
sparser
"The proximal Kv7.1 C-terminus binds calmodulin (CaM) and phosphatidylinositol-4,5-bisphosphate (PIP 2 ) and recently we revealed the competition of PIP 2 with the calcified CaM N-lobe to a previously unidentified site in Kv7.1 helix B, also known to harbor a LQT mutation."
28976808
sparser
"Disruption of CaM interactions with Kv7.1 ( Ghosh et al., 2006; Shamgar et al., 2006 ), Kv7.2 ( Etxeberria et al., 2008 ), and the Kv7.2/Kv7.3 heteromer ( Liu and Devaux, 2014 ) by disease mutations has indicated that CaM-Kv7 complex formation is important for channel assembly and trafficking and, together with other studies, support the idea that CaM is an auxiliary subunit ( Etxeberria et al., 2008; Gamper et al., 2005; Gamper and Shapiro, 2003; Ghosh et al., 2006; Levitan, 2006; Shamgar et al., 2006; Wen and Levitan, 2002; Yus-Najera et al., 2002 )."
29429937
sparser
"Earlier reports of constitutive association of the Ca 2+ -binding protein calmodulin (CaM) with the C-terminus of KCNQ1 (Yus-Najera et al., xref ; Ghosh et al., xref ; Shamgar et al., xref ; Ciampa et al., xref ) prompted us to consider intracellular Ca 2+ as a putative ligand for KCNQ1-CaM complex."
22866036
reach
"This study describes one physiological form of KCNQ1, depolarized voltage sensors with a closed pore in the absence of PIP 2, and reveals a regulatory interaction between CaM and KCNQ1 that may explain CaM mediated LQTS."
28575668
sparser
"Mutation in the CaM-binding motifs of KCNQ1 [29] is associated with LQTS."
26164367
sparser
"Helix A (residues 370–386) and helix B (residues 504–531) mediate binding of KCNQ1 with CaM, which is required for normal KCNQ1 channel gating, folding and membrane trafficking [9–11] ."
24713462
reach
"To test whether CaM binding to KCNQ1 was dissociated by PIs, we fused each of the two C-terminal KCNQ1 CaM binding regions (CBS1 and CBS2) to MBP and performed competition assays."
17317623
sparser
"This disturbed calmodulin- Kv7.1 interaction may be important for channel expression."
24600393
sparser
"Other mutations that affect PIP 2 or CaM binding to KCNQ1 underlie certain forms of the long QT syndrome and can result in sudden cardiac death ( Park et al., 2005; Ghosh et al., 2006; Shamgar et al., 2006 )."
17317623
sparser
"Formation of functional tetramers requires CaM interaction with the KCNQ1 C-terminus."
16556866
reach
"Earlier reports of constitutive association of the Ca 2+ -binding protein calmodulin (CaM) with the C-terminus of KCNQ1 prompted us to consider intracellular Ca 2+ as a putative ligand for KCNQ1 and CaM complex."
22866036
sparser
"A recent cryo-EM study showed that each Kv7.1 subunit associates with one calmodulin molecule [ xref ]."
29451064
sparser
"Interestingly, co-immunoprecipitation experiments in yeast cells expressing wild-type Kv7.1 or mutated Kv7.1 with truncated α-helices showed that calmodulin can bind to the C-terminus of Kv7.1 ( xref )."
24600393
sparser
"These studies were motivated by the observed similarities between the suppression of KCNQ1 function by pharmacological disruption of KCNQ1-CaM interactions and the effects of KCNE4 co-expression on the channel."
21118809
reach
"Other mutations that affect PIP 2 or CaM binding to KCNQ1 underlie certain forms of the long QT syndrome and can result in sudden cardiac death (Park et al., 2005; Ghosh et al., 2006; Shamgar et al., 2006)."
17317623
sparser
"Functional and biochemical analysis of LQTS mutations in the KCNQ1 C-terminus showed that disruption of CaM interaction with KCNQ1 interfered with subunit assembly and that the resultant channels generated very small currents."
19333131
reach
"The recently published cryo-EM structure of the KCNQ1 and CaM complex [12] falls within the conformational space of possible structures in the library."
30292722
sparser
"Functionally, IKs is regulated by a number of interacting proteins and post‐translational modifications. xref – xref The IKs currents and the channel subunits KCNQ1 and KCNE1 proteins are regulated by the β‐adrenergic‐mediated protein kinase A– dependent phosphorylation, a process that might be pathogenic in heart failure. xref , xref – xref Likewise, IKs are calcium‐responsive currents, partly because of interaction of the KCNQ1 with calmodulin, which is a constitutive component of the K + channels. xref One might speculate that altered interactions of KCNQ1 and calmodulin, in the presence of KCNQ1 mutations, could perturb intracellular calcium homeostasis and affect the contractile performance of cardiac myocytes."
25616976
sparser
"In addition, the CaM- Kv7.1 interaction may also be relevant for the regulation of I Ks gating."
24600393
sparser
"The structural data presented here, namely the Kv7.1 proximal C terminus bound to CaM, provide us with a near atomic resolution picture of this module."
25441029
reach
"Functional and biochemical analysis of LQTS mutations in the KCNQ1 C-terminus showed that disruption of CaM interaction with KCNQ1 interfered with subunit assembly and that the resultant channels generated very small currents."
19333131
reach
"Helix A (residues 370-386) and helix B (residues 504-531) mediate binding of KCNQ1 with CaM, which is required for normal KCNQ1 channel gating, folding and membrane trafficking [9-11]."
24713462
reach
"Cryo-EM Structure of a KCNQ1 and CaM Complex Reveals Insights into Congenital Long QT Syndrome."
28575668
sparser
"Our data indicate that in healthy individuals, CaM binding to KCNQ1 is essential for correct channel folding and assembly and for conferring Ca(2+)-sensitive IKS-current stimulation, which increases the cardiac repolarization reserve and hence prevents the risk of ventricular arrhythmias."
16556865
sparser
"To test if the mutant M520R disrupts channel function by impairing the interaction of Kv7.1 with CaM, we performed yeast two-hybrid experiments ( Fig. 4 B)."
17482572
sparser
"This study describes one physiological form of KCNQ1, depolarized voltage sensors with a closed pore in the absence of PIP 2 , and reveals a regulatory interaction between CaM and KCNQ1 that may explain CaM-mediated LQTS."
28575668
sparser
"Therefore, we considered the M520R mutation to affect the CaM-Kv7.1 interaction."
17482572
sparser
"A redox motif flanking Cys(445) and the interaction of KCNQ1 with calmodulin are required for preferential S-nitrosylation of Cys(445)."
19124472
reach
"Our data indicate that in healthy individuals, CaM binding to KCNQ1 is essential for correct channel folding and assembly and for conferring Ca (2+)-sensitive IKS-current stimulation, which increases the cardiac repolarization reserve and hence prevents the risk of ventricular arrhythmias."
16556865
sparser
"Relevant to this question, CaM’s binding target can affect CaM’s affinity for Ca 2+ , so that it is possible that when CaM associates with the Kv7.1 proximal C terminus, CaM N lobe Ca 2+ affinity increases dramatically ( Olwin and Storm, 1985; Zhang et al., 2012 )."
25441029
reach
"One possibility is that Ca 2+ binding to KCNQ1 bound calmodulin exerts conformational effects that can be transmitted to co-assembled SMITs to Ca 2+ -dependently regulate myo-inositol intake."
28718502
sparser
"Together, these data support the idea that Apo/CaM:Kv7.4 interactions are essential for proper trafficking and are reminiscent of effects reported for mutations that disrupt the interaction between CaM and Kv7.1 ( Ghosh et al., 2006; Shamgar et al., 2006 ), Kv7.2 ( Etxeberria et al., 2008 ), and the Kv7.2/Kv7.3 heteromeric channel ( Liu and Devaux, 2014 )."
29429937
sparser
"To test whether CaM binding to KCNQ1 was dissociated by PIs, we fused each of the two C-terminal KCNQ1 CaM-binding regions (CBS1 and CBS2) to MBP and performed competition assays."
17317623
sparser
"Indeed, structural comparison with the Apo/CaM:Kv7.4 AB domain complex shows that despite the differences in EF4, which is ion bound in the CaM:Kv7.1 complex but empty in the Apo/CaM Kv7.4 complex, both EF3s have similar conformations ( Figure 8 A)."
29429937
CALM binds KCNQ1 and KCNQ2. 1 / 1
| 1
sparser
"WT and mutant Kv7.1 C-termini and Kv7.2 C-terminus did interact with CaM as assayed by HIS3 induction in the GAL4 based yeast two-hybrid system ( Fig. 4 B) while the negative controls did not produce any signal."
17482572
CALM binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"KCNE1 forms a ternary complex with wild-type KCNQ1 and Ca(2+)-CaM that prevents inactivation, facilitates channel assembly, and mediates a Ca(2+)-sensitive increase of IKS-current, with a considerable Ca(2+)-dependent left-shift of the voltage-dependence of activation."
16556865
CALM binds AOPEP and KCNQ1. 1 / 1
| 1
sparser
"Yeast two-hybrid assay also suggests that KCNQ1 associates with apo-CaM."
19333131
CALM binds CAMK2_complex, KCNE1, and KCNQ1. 1 / 1
| 1
sparser
"Thus, the interaction of calmodulin and Kv7.1 appears to be critical for expression and function of I Ks , with the intriguing possibility that regulatory mechanisms could also involve some form of CaMKII interaction with calmodulin and Kv7.1 or KCNE1."
24600393
KCNQ1 affects AKAP9
2 1 | 1 25 6
AKAP9 binds KCNQ1. 26 / 26
2 1 | 1 18 5
reach
"51 The inherited S1570L mutation reduces the interaction between KCNQ1 and Yotiao, reduces the cAMP induced phosphorylation of the channel, eliminates the functional response of the IKs channel to cAMP, and prolongs the action potential in a computational model of the ventricular cardiac myocytes."
21978991
reach
"In the case of KCNQ1, loss of interaction between AKAP9 and KCNQ1 leads to a potentially fatal heart condition, long-QT syndrome, which also arises in cases with loss of function mutations in KCNQ1 itself [XREF_BIBR]."
24467814
reach
"A mutation in AKAP9 in the KCNQ1 binding domain reduces the interaction between KCNQ1 and AKAP9 blunting physiologic adrenergic mediated increase in I Ks thereby generating the LQT11 phenotype."
24561134
sparser
"Thus far, four non-ion channel LQTS-susceptibility genes have been discovered: (1) the ankyrin-B gene, which encodes a protein that functions as a cytoskeletal membrane adapter and is involved with the sodium pump, the sodium/calcium exchanger, and the inositol-1,4,5-triphosphate receptors, and can cause LQT4 when mutated ( xref ); (2) caveolin-3, which alters gating kinetics in the cardiac sodium channel, and if mutated may result in an increase in sustained late sodium current (Nav1.5; LQT9)( xref ; xref ); (3) AKAP9 (LQT11), mutation of which reduces the interaction between KCNQ1 and AKAP9 (Yotiao), reduces the cAMP-induced phosphorylation of the channel, eliminates the functional response of the IKs channel to cAMP, and prolongs the QT interval ( xref ); (4) SNTA1 (LQT12), which when mutated increases direct nitrosylation of SCN5A and results in augmentation of late sodium current ( xref )."
20809527
sparser
"Later, Kurokawa et al reconstituted such effects in a recombinant expression system by coexpressing AKAP9 (Yotiao) and demonstrated that AKAP9 forms a macromolecular complex with KCNQ1, Type II regulatory subunit of PKA (RII), and protein phosphatase 1 (PP1) and brings PKA to the vicinity of the channel to phosphorylate a serine residue (S27) on KCNQ1 amino terminus xref ."
21885989
sparser
"A previously known LQT mutation (G589D) near the LZ motif disrupted the interaction between Yotiao and KCNQ1 as well as the functional regulation of I Ks by PKA phosphorylation xref ."
21885989
sparser
"Specifically, recent findings from Kass and Ackerman have identified AKAP9-S1570L which markedly diminishes the interaction of yotiao with KCNQ1, resulting in reduction in PKA-dependent phosphorylation of Kv7.1, and thus striking inhibition of I KS regulation by cAMP. xref Similar to models of LQT1 - associated mutations in KCNQ1 that block yotiao binding and I KS phospho-regulation, yotiao mutations are also predicted to prolong the action potential and increase arrhythmia susceptibility (now termed type 11 long QT syndrome). xref In support of this notion, the S1570L proband displayed a clinical LQTS phenotypes (now referred to as type 11 long QT syndrome; MIM#611820) similar to LQT1 mutations that block KCNQ1 association with yotiao (female, QT c 485 ms presenting with syncope and family history of LQTS). xref Together, these two related studies have revealed the critical importance of local regulation of ion channels by accessory ChIPs, as well as demonstrate the power of combining clinical genetics and molecular/cellular cardiology to drive disease discovery."
20724725
sparser
"The previous studies have reported that the G589D mutation disrupts the interaction of the KCNQ1 subunit with Yotiao [13] , and this results in massive reduction of membrane trafficking and I Ks density [25,26] ."
24713462
sparser
"Previous studies have suggested that the KCNQ1(G589D) mutation disrupts the interaction of KCNQ1 with Yotiao, leading to a loss of β-adrenergic receptor-mediated modulation of the channel [13,27,28] ."
24713462
biogrid
No evidence text available
11799244
reach
"XREF_BIBR In this report, it has been hypothesized that mutations in AKAP9 may lead to arrhythmia by disrupting the interaction between AKAP9 and KCNQ1 encoded potassium channels."
28491551
sparser
"A subset of these mutations in either Yotiao (S1570L) or KCNQ1 (G589D) disrupts the KCNQ1–Yotiao interaction, resulting in altered regulation of the I Ks channel [ xref ]."
29367580
sparser
"Similar to RyR and the L type Ca 2+ channel, KCNQ1 binds to yotiao through LIZ mediated interactions."
12623298
sparser
"Prior work has shown that G589D is able to abolish sympathetic regulation of cardiac I Ks currents by disrupting the assembly of a macromolecular complex of Kv7.1 and the scaffolding protein yotiao ( Marx et al., 2002 )."
17329207
hprd
No evidence text available
11799244
reach
"A previously known LQT mutation (G589D) near the LZ motif disrupted the interaction between Yotiao and KCNQ1 as well as the functional regulation of I Ks by PKA phosphorylation 15."
21885989
sparser
"The helix D region of KCNQ1 subunit contains G589, the amino acid that has been suggested to be important for interaction between KCNQ1 and Yotiao and the cAMP-dependent modulation of I Ks [13] ."
24713462
sparser
"AKAP9 binds KCNQ1 carboxy terminus via a leucine zipper (LZ) motif."
21885989
sparser
"The disruption of the cAMP-dependent I Ks regulation by mutations in helix D indicates that Yotiao interacts with KCNQ1 through this domain [13] ."
24713462
sparser
"In heart, sympathetic nervous system regulation of cardiac action potential duration, mediated by the βAR receptor, requires assembly of Yotiao with KCNQ1. xref The control of the sympathetic nervous system over the duration of cardiac action potential requires PKAmediated phosphorylation of the KCNQ1 subunit of the I Ks channel with the consequent increase in I Ks current, accelerated repolarization and increased heart rate."
21978991
sparser
"Moreover, KCNQ1(A590T) subunit interacted with Yotiao and had a cAMP-responsiveness comparable to that of KCNQ1(WT) subunit."
24713462
biogrid
No evidence text available
11799244
sparser
"But in this case, increasing mechanistic detail was used to represent the reversible binding of yotiao to KCNQ1 and the reversible binding of PKA and PP1 to yotiao."
21562426
sparser
"KCNQ1 binds to yotiao [5] , a 210 kDa AKAP that has previously been shown to co-localize the NMDA receptor, PKA and PP1 in the brain [88] ."
12623298
sparser
"A single mutation S1570L in Yotiao, localized to the C-terminal KCNQ1 binding domain, is found in 2% subjects with a clinically robust phenotype for LQT syndrome. xref The inherited S1570L mutation reduces the interaction between KCNQ1 and Yotiao, reduces the cAMP-induced phosphorylation of the channel, eliminates the functional response of the I Ks channel to cAMP, and prolongs the action potential in a computational model of the ventricular cardiac myocytes."
21978991
sparser
"A mutation in AKAP9 in the KCNQ1 binding domain reduces the interaction between KCNQ1 and AKAP9 blunting physiologic adrenergic-mediated increase in I Ks thereby generating the LQT11 phenotype ( xref )."
24561134
ADCY9 binds AKAP9 and KCNQ1. 2 / 2
| 2
sparser
"Importantly, formation of a KCNQ1–yotiao–AC9 complex sensitized KCNQ1 to β-adrenergic receptor stimulation, allowing the channel to respond to significantly lower concentrations of agonist ( xref )."
24378903
sparser
"The interaction of AC9 with Yotiao and KCNQ1 was shown by immunoprecipitation of the complex from cells co-expressing all three proteins, a transgenic mouse line with cardiac expression of KCNQ1–KCNE1, and from guinea pig hearts, which endogenously express the complex."
29367580
PKA binds AKAP9 and KCNQ1. 2 / 2
| 2
sparser
"We have previously shown that adenylyl cyclase Type 9 (AC9) is associated with a KCNQ1-Yotiao-PKA complex and facilitates isoproterenol-stimulated phosphorylation of KCNQ1 in an immortalized cell line."
31461851
sparser
"Molecular mechanistic studies showed that this mutation partially inhibits protein-protein interactions of KCNQ1-AKAP9, leading to decreased PKA-mediated phosphorylation of KCNQ1."
29370121
TUBB3 binds AKAP9 and KCNQ1. 1 / 1
| 1
sparser
"Although most of this subset remains genotype negative, mutations occurring at 1% frequency have been identified in a variety of ion channels or channel interacting proteins: cytoskeletal protein ankyrin B (LQT4), xref KCNQ1 beta-subunit minK (LQT5), xref HERG beta-subunit MiRP1(LQT6), xref potassium channel Kir2.1 (LQT7), xref L-type calcium channel (Timothy syndrome/LQT8), xref caveolin-3 (LQT9), xref beta4 subunit of the sodium channel (LQT10), xref AKAP9 -encoded adaptor protein yotiao, which interacts with KCNQ1 (LQT11), xref and cytoskeletal sodium channel regulator α 1 -syntrophin (LQT12). xref "
18823823
AKAP9 binds KCNQ1 and leucine. 1 / 1
| 1
reach
"AKAP9 binds KCNQ1 carboxy terminus via a leucine zipper (LZ) motif."
21885989
AKAP9 binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"KCNQ1, Yotiao and KCNE1 were detected in the anti-KCNQ1 immunoprecipitates from all the cell groups, suggesting that the KCNQ1(A590T) or KCNQ1(G589D) mutation did not disrupt the KCNQ1–KCNE1–Yotiao interaction ( Fig. 4 )."
24713462
PKA binds PPP1, AKAP9, KCNQ1, and sch1. 1 / 1
| 1
sparser
"Notably, I KS activity is tightly regulated by PKA-dependent phosphorylation, and this phosphorylation is tuned by both local PKA and PP1 signaling cascades. xref In heart, yotiao directly associates with Kv7.1 to recruit both PKA and PP1 to regulate I KS phosphorylation and gating ( xref ). xref Moreover, the LQT1-causative mutation, G589D abolishes Kv7.1’s association with yotiao thereby disrupting the channel’s sensitivity to beta-adrenergic regulation. xref "
20724725
KCNQ1 affects INS
| 2 27
KCNQ1 inhibits INS.
| 13
KCNQ1 inhibits INS. 13 / 13
| 13
reach
"Kcnq1 impairs insulin secretion by enhancing the beta-cell potassium currents."
28343791
reach
"In contrast, it was reported that an inhibitor of KCNQ1 (chromanol 293B) significantly increased insulin secretion in the presence of sulfonylurea; this finding suggested that the activity of KCNQ1 in subjects with the C allele of rs2237897, a risk allele for type 2 diabetes, might be higher than that in subjects with the T allele, a risk allele for diabetic nephropathy in the present study."
20056949
reach
"Inhibition of KCNQ1 channel activity by the selective inhibitor chromanol 293B significantly increases insulin secretion in INS-1 cells XREF_BIBR, whereas KCNQ1 overexpression in MIN6 cells results in markedly impaired insulin secretion by glucose, pyruvate, or tolbutamide XREF_BIBR."
26678516
reach
"Mutation of CDKAL1, KCNQ1 or KCNJ11 Differentially Impairs Insulin Secretion in Response to Multiple Secretagogues."
27524441
reach
"These data are consistent with the idea that increased KCNQ1 function impairs insulin secretion by inducing premature repolarization of the action membrane potential in pancreatic beta cells."
24843522
reach
"Inhibition of KCNQ1 in beta-cells increases insulin secretion."
24357532
reach
"KCNE2 may regulate multiple K + channels in beta cells, including the T2DM linked KCNQ1 potassium channel alpha subunit.-Lee, S. M., Baik, J., Nguyen, D., Nguyen, V., Liu, S., Hu, Z., Abbott, G. W. Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus."
28280005
reach
"Attenuation of KCNQ1 channel activity by the selective inhibitor chromanol 293B was found to enhance insulin secretion induced by tolbutamide in INS-1 cells."
24843522
reach
"It is also expressed in pancreatic islets, and blockade of the KvLQT1 channel stimulates insulin secretion in insulin secreting INS-1 cells XREF_BIBR."
20174558
reach
"A Variant in the KCNQ1 Gene Predicts Future Type 2 Diabetes and Mediates Impaired Insulin Secretion."
19584308
reach
"In mice, Kcnq1 gene deletion causes deafness, loss of gastric acid secretion, altered insulin sensitivity, and hypothyroidism."
27098917
reach
"In a physiological study in INS-1 cell cultures, the blockade of the KvLQT1 channel with KCNQ1 protein inhibitor 293B stimulated insulin secretion in the presence of sulphonylurea drug tolbutamide [XREF_BIBR], suggesting that KvLQT1 channels might play a role in fine tuning of insulin secretion during sulphonylurea treatment."
21709633
reach
"Loss of KCNQ1 expression may impair repolarisation of the beta cell and lead to failure to turn off insulin secretion."
26545876
KCNQ1 activates INS.
| 13
KCNQ1 activates INS. 13 / 13
| 13
reach
"This case story presents a patient with a gain-of-function mutation KCNQ1 R670K with low glucose stimulated C-peptide secretion, additionally suggesting involvement of the voltage gated potassium channel KCNQ1 in glucose stimulated insulin regulation."
32164657
reach
"This case story presents a patient with a gain-of-function mutation KCNQ1 R670K with low glucose stimulated C-peptide secretion, additionally suggesting involvement of the voltage gated potassium channel KCNQ1 in glucose stimulated insulin regulation."
32164657
reach
"The primary aim of the present study was to investigate the putative impact of these KCNQ1 polymorphisms (rs2283228, rs2237892, rs2237895, and rs2237897) on estimates of glucose stimulated insulin release."
19516902
reach
"12 KCNQ1 is present in adipose tissue and mediates insulin secretion; the mutation of the KCNQ1 gene has been shown to be associated with susceptibility to T2DM 13 and to PTDM."
30258870
reach
"In this study, KCNQ1 rs2237892 SNP was not only associated with a risk for GDM, but also with increased 1h and 2h glucose levels which was consistent with the known association between this SNP and glucose stimulated insulin secretion."
26039078
reach
"Further, the CRISPR and Cas9 mediated deletion of CDKAL1, KCNJ11, and KCNQ1 genes in hESCs disrupted the regulated production of insulin in differentiated beta cells."
30046616
reach
"KCNQ1 knockout mice have cardiac dysfunctions XREF_BIBR, XREF_BIBR and enhanced systemic insulin sensitivity XREF_BIBR."
20174558
reach
"For T2DM, KCNQ1 is produced in the pancreatic islets, and the specific KCNQ1 blocker 293B stimulates insulin secretion XREF_BIBR."
24373634
reach
"In mice, the deletion of the Kcnq1 gene leads to decreased non fasted plasma glucose and insulin concentrations (Boini et al., 2009)."
26970180
reach
"The risk allele of lead SNP at KCNQ1 is associated with impaired insulin secretion (Unoki et al., 2008; Yasuda et al., 2008) and reduced insulin exocytosis in patients (Rosengren et al., 2012), and Kcnq1 -/- mice have impaired glucose stimulated insulin secretion (GSIS) (Boini et al., 2009)."
27524441
reach
"Inhibition of Kv7.1, as well as KCNQ1 knockdown with siRNA, increased exocytosis and insulin secretion in pancreatic beta-cells."
29259974
reach
"4.2 Potential role of KCNQ1 mediating insulin sensitivity and beta cell function."
30641161
reach
"Expression of KCNQ1 and glucose stimulated insulin secretion in human pancreatic islets."
19584308
KCNQ1 binds INS.
| 2
INS binds KCNQ1. 2 / 2
| 2
sparser
"Common genetic variation in KCNQ1 is associated with insulin secretion upon oral glucose load in a German population at increased risk of type 2 diabetes."
19366866
sparser
"However, the KCNQ1 rs2237892 polymorphism was associated with levels of fasting insulin (FINS), postprandial serum insulin (PINS) and HOMA-IR and HbA1c (%); individuals with the CC genotype had noticeably lower FINS ( P  < 0.05), PINS ( P  < 0.01), and HOMA-IR ( P  < 0.05) with higher HbA1c (%) ( P  < 0.05) levels than those individuals with other genotypes ( xref )."
27857189
KCNQ1 decreases the amount of INS.
| 1
Modified KCNQ1 decreases the amount of INS. 1 / 1
| 1
reach
"Of importance is that KCNQ1 overexpression may lead to decreased levels of insulin and development of type 2 diabetes."
29259974
KCNQ1 affects PSMD4
| 11 10
KCNQ1 binds PSMD4.
| 11
KCNQ1 binds PSMD4. 8 / 8
| 8
sparser
"This is consistent with the findings of xref who reported that recurrent AF associated with the KCNQ1 V141M mutation was unresponsive to multiple anti-arrhythmic agents (failing to revert to sinus rhythm), including (hydro)quinidine ( xref )."
30337886
sparser
"For example, while most KCNQ1 mutations associated with AF cause gain of function, a few loss-of-function mutations have been identified in familial AF patients."
27261823
sparser
"However, despite identification of other KCNQ1 mutations associated with AF, 14 the prevalence of KCNQ1 mutations probably is low, 15 in accordance with the finding that AF is genetically heterogeneous."
18313602
sparser
"Most of the identified gain-of-function KCNQ1 mutations associated with AF show similar slowed deactivation kinetics to various degrees [ xref – xref , xref , xref ]."
27261823
sparser
"A gain of function in I Ks secondary to a KCNE1 deletion in mice 43 or KCNQ1 mutation in humans 11,14,15 has been associated with the development of AF."
18313602
sparser
"KCNQ1 mutations have previously been described in AF, yet this is the first time a mutation in KCNQ1 is associated with age-dependent bradycardia and persistent AF."
23989646
sparser
"Mutations in the IKs channel leading to gain-of-function have previously been described in familial AF, yet this is the first time a loss-of-function mutation in KCNQ1 is associated with early-onset lone AF."
25786344
sparser
"Interestingly, a cluster of gain of function KCNQ1 mutation that are associated with AF (S140G, V141M, Q147R) are located in this part of S1."
22529812
KCNH2 binds KCNJ2, KCNQ1, and PSMD4. 2 / 2
| 2
sparser
"In addition, AF has been associated with rare gain of function mutations in KCNQ1, hERG and KCNJ2 causing the short QT syndrome and sudden death."
16887036
sparser
"This is largely due to reduced L-type Ca 2+ current, although rare gain-of-function mutations in KCNQ1 [ xref ], hERG [ xref ], Kir2.1 [ xref ] and KCNE ancillary subunits [ xref ] have also been associated with AF due to increases in channel conductance."
20670193
KCNE2 binds KCNQ1 and PSMD4. 1 / 1
| 1
sparser
"Mutations in KCNE2 and/or KCNQ1 have previously been associated with LQTS, AF, and even early-onset myocardial infarction ( xref ; xref ; xref ; xref ; xref ), each of which is also predisposed to by thyroid dysfunction in the general population ( xref ; xref ; xref ), suggesting the intriguing possibility of an endocrine component to some KCNE2- and KCNQ1-associated human cardiac disease."
20688187
KCNQ1 activates PSMD4.
| 10
KCNQ1 activates PSMD4. 6 / 6
| 6
reach
"Although rare, mutations in KCNQ1 also can cause familial AF."
23193492
reach
"R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation."
20850564
reach
"In 2005, Hong et al XREF_BIBR identified a missense mutation (p.V141M) in the KCNQ1 gene, which causes AF and shortens the QT interval by altering the gating of IKs channels -- to our knowledge, the only pathogenic mutation associated with this rare entity, so far."
28491547
reach
"A second gain-of-function mutation in the KCNQ1 gene has since been found to cause AF in a child before birth, and in this case occurred along with the expected shortening of the QT interval [XREF_BIBR]."
16887036
reach
"A more recent study revealed that lncRNA KCNQ1 overlapping transcript1 (KCNQ1OT1) is upregulated in Ang-II-induced AF mice hearts and promotes Ang-II-induced AF by acting as a sponge for miR-384b to facilitate CACNA1C expression."
30894138
reach
"For example, mutations in the potassium channel gene KCNQ1, the first gene linked to familial AF, are thought to cause AF by reducing the atrial action potential duration and the effective refractory period."
29050564
Mutated KCNQ1 activates PSMD4. 2 / 2
| 2
reach
"Although mutation in KCNQ1 has been correlated with AF, the mechanism by which KCNQ1 mutation promotes AF remains poorly understood."
25230101
reach
"The mechanisms whereby some KCNQ1 mutations produce AF and others generate ventricular phenotypes remains to be determined."
19646991
KCNQ1-R14C activates PSMD4. 1 / 1
| 1
reach
"These data suggest that the R14C KCNQ1 mutation alone is insufficient to cause AF."
17276182
KCNQ1-S140G activates PSMD4. 1 / 1
| 1
reach
"This hypothesis needs to be further examined by measuring properties of the AP and the HMR1556 sensitive current in myocytes obtained from both normal and transgenic mice.We have shown that KCNQ1 S140G mutation may initiate or maintain human AF."
17467630
3',5'-cyclic AMP affects KCNQ1
| 2 19
3',5'-cyclic AMP activates KCNQ1.
| 2 13
3',5'-cyclic AMP activates KCNQ1. 13 / 13
| 2 13
reach
"It is known that Cl - secretion induced by quercetin does not require the activation of cyclic AMP activated K + basolateral KCNQ1 and KCNE3 channels (Cermak et al., 2002)."
12799067
reach
"Because XREF_FIG suggests that co-expression of KCNE2 and KCNQ1 should result in functionally responsive channels to cAMP challenges, we next tested whether an external application of a membrane permeable cAMP (cpt-cAMP) enhances KCNE2 and KCNQ1 currents (note that in all experiments Yotiao was also expressed)."
19077539
reach
"KCNQ1 currents were activated by an increase in intracellular cAMP, independent of coexpression with KCNE1 or KCNE3."
11426298
reach
"We detected endogenously expressed KCNQ1 and KCNE2 proteins, which appeared to be upregulated by TSH or its major downstream effector, cAMP, in FRTL5 cell membrane fractions (XREF_FIG)."
19767733
reach
"Both types take part in Cl - secretion in rat colon : Ca 2+ -dependent rSK4 channels (Warth et al., 1999) and cyclic AMP activated KCNQ1 and KCNE3 channels (Schroeder et al., 2000)."
12799067
reach
"FFA also inhibited activities of CFTR, a cAMP activated apical Cl - channel, and KCNQ1 and KCNE3, a cAMP activated basolateral K + channel."
28651800
reach
"Mutations at KCNQ1 residue 27 ablated the cAMP induced enhancement of KCNE2 and KCNQ1 currents regardless of substituted amino acid residue (XREF_FIG), suggesting that the cAMP dependent functional regulation is a consequence of PKA mediated phosphorylation at Ser 27 of KCNQ1."
19077539
reach
"The cAMP activated cystic fibrosis transmembrane conductance regulator (CFTR) and KCNQ1 channels in tracheal epithelium play key roles in luminal and basolateral membranes, respectively."
17567648
reach
"Elevations in the levels of cAMP, cyclic guanosine monophosphate (cGMP), and Ca 2+ activate apical Cl - channels (CFTR and CaCC) and basolateral K + channels (KCNQ1 and KNE3, KCNN4)."
22850599
reach
"In summary, we have shown for the first time that cAMP stimulated KCNQ1 and KCNE3 channels reside in the basolateral membrane of healthy human colonic crypt cells, and that their activity is increased in active UC."
26718405
reach
"Specifically, this mutation disrupts the binding between KCNQ1 and Yotiao, reduces PKA phosphorylation of KCNQ1, and eliminates the cAMP induced response of KCNQ1 [XREF_BIBR]."
20689672
reach
"Relevant colonic epithelial K+ channels are the intermediate conductance Ca2 +-activated K (Ca) 3.1 (SK4) channel and the cAMP activated K (V) 7.1 (KCNQ1) channel."
17305705
reach
"The gastric KCNQ1 and KCNE channels are activated by cAMP [XREF_BIBR - XREF_BIBR], which thus stimulates gastric acid secretion [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
21113728
3',5'-cyclic AMP inhibits KCNQ1.
| 3
3',5'-cyclic AMP inhibits KCNQ1. 3 / 3
| 3
reach
"Further, at least two KCNE1 mutations linked to LQT-5 (D76N and W87R) cause functional disruption of cAMP mediated KCNQ1 and KCNE1-channel regulation despite the response of the substrate protein (KCNQ1) to protein kinase A phosphorylation."
12566567
reach
"In RNF5WT and CFTRWT animals, addition of the cAMP elevating agent forskolin to the serosal side of tissue induces a negative shift in transepithelial potential difference (and therefore in the equivalent short-circuit current) reportedly due to cAMP dependent activation of the apical CFTR and of the basolateral potassium channel KCNQ1 and KCNE3, which enables recycling of potassium through the basolateral membrane and maintenance of membrane potential favorable to chloride efflux (XREF_FIG)."
26183966
reach
"Basolateral UDP induced a sustained activation of Cl (-) secretion, which was completely inhibited by 293B, a specific inhibitor of cAMP stimulated basolateral KCNQ1 and KCNE3 K (+) channels."
12569163
3',5'-cyclic AMP phosphorylates KCNQ1.
| 2
3',5'-cyclic AMP phosphorylates KCNQ1. 2 / 2
| 2
reach
"The results of these experiments, summarized in XREF_FIG, indicate that KCNQ1 is phosphorylated in response to cAMP independent of co-expression of any of these beta subunits."
19077539
reach
"During beta-adrenergic stimulation, 3 '-5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) phosphorylates KCNQ1, producing an increase in I Ks current and a shortening of the action potential."
28687606
3',5'-cyclic AMP increases the amount of KCNQ1.
| 1
3',5'-cyclic AMP increases the amount of KCNQ1. 1 / 1
| 1
reach
"We now show that cAMP mediated functional regulation of KCNQ1 and KCNE1 channels, a consequence of cAMP dependent protein kinase A phosphorylation of the KCNQ1 N terminus, requires coexpression of KCNQ1 with KCNE1, its auxiliary subunit."
12566567
KCNQ1 affects MINK1
| 1 17
MINK1 binds KCNQ1. 18 / 18
| 1 17
reach
"Thus, KVLQT1 interacts with minK to form the cardiac slowly activating, delayed rectifier I Ks current."
9791861
reach
"10 Thus, minK interacts with both KCNQ1 and HERG, and KCNE1-3 proteins interact with Kv3.1 and Kv3.2 causing diversification of channel gating."
18313602
reach
"Gating of the delayed rectifier K+ channel KvLQT1 is drastically slowed by the association with the small membrane protein minK and it is thought that the KvLQT1 and minK complex underlies the slow delayed rectifier K+ current of cardiac cells."
9817805
reach
"While MinK and KvLQT1 complexes recreate the behaviors of I Ks channels, MiRP1 and HERG complexes recapitulate those of I Kr channels."
10219239
reach
"These efforts have left many unanswered questions regarding how MinK interacts with KvLQT1."
10962015
reach
"Finally, for modulation to occur, MinK must presumably associate with KvLQT1, but it was previously unknown whether this involves the same or different structures responsible for the gating and current amplitude effects."
10962015
reach
"KvLQT1 and minK associate to form the functional slowly activated delayed rectifier potassium channel (I Ks) [12,13] while HERG and MiRP1 associate to form the rapidly activated delayed rectifier potassium channel (I Kr) [10]."
12051962
reach
"There is controversy about the effects of the association between KvLQT1 and minK on the single-channel conductance."
9817805
reach
"This article reviews some of the recent work addressing the prototypical KCNE-channel interaction between minK and KvLQT1."
12069759
reach
"Here we show that the KCNQ1 and minK interaction is influenced by the expression system."
11680622
reach
"Understanding how MinK associates with KvLQT1 and identifying subregions involved in gating modulation may provide insight into the mechanism by which MinK modulates KvLQT1."
10962015
reach
"These results suggested that SCN5A mutations act through a gain-of-function mechanism (the mutant channel functions normally, but with altered properties) and that the mechanism of chromosome-3-linked LQT is the persistent non inactivated Na + current in the plateau phase of the cardiac action potential.Recent physiological studies suggest that minK interacts with KVLQT1 to form the slowly activating, delayed rectifier K + channel (I Ks)."
9791861
reach
"The presence and co-assembly of KvLQT1 and MinK in mouse brain (XREF_FIG) suggests that the protein may modulate neuronal excitability as a KvLQT1 and MinK complex as I KS does in heart."
20368164
reach
"It is already known, for example, that minK can interact with KVLQT1 and HERG when overexpressed in heterologeous systems (McDonald et al., 1997)."
11239413
sparser
"A second current in this type is the, I Ks component mediated by heteromeric channel formed by Kv7.1 and MINK subunit protein that are encoded by KCNQ1 and KCNE1 genes, respectively."
25185978
reach
"8,9 The minK and KvLQT1 complex channel is responsible for the slowly activating component of the delayed rectifier K + channel (I Ks channel), and I Ks is important for the repolarization of cardiac myocytes."
11697903
reach
"Because KvLQT1 subunits give rise to functional potassium channels when expressed alone, it is interesting to consider the nature of the interaction between minK and KvLQT1 that produces larger and more slowly activating currents when these genes are coexpressed."
9834139
reach
"To modulate gating and current amplitude, MinK presumably must associate with KvLQT1 in a specific manner."
10962015
PSMD4 affects KCNQ1
| 11 6
PSMD4 binds KCNQ1.
| 11
KCNQ1 binds PSMD4. 8 / 8
| 8
sparser
"This is consistent with the findings of xref who reported that recurrent AF associated with the KCNQ1 V141M mutation was unresponsive to multiple anti-arrhythmic agents (failing to revert to sinus rhythm), including (hydro)quinidine ( xref )."
30337886
sparser
"For example, while most KCNQ1 mutations associated with AF cause gain of function, a few loss-of-function mutations have been identified in familial AF patients."
27261823
sparser
"However, despite identification of other KCNQ1 mutations associated with AF, 14 the prevalence of KCNQ1 mutations probably is low, 15 in accordance with the finding that AF is genetically heterogeneous."
18313602
sparser
"Most of the identified gain-of-function KCNQ1 mutations associated with AF show similar slowed deactivation kinetics to various degrees [ xref – xref , xref , xref ]."
27261823
sparser
"A gain of function in I Ks secondary to a KCNE1 deletion in mice 43 or KCNQ1 mutation in humans 11,14,15 has been associated with the development of AF."
18313602
sparser
"KCNQ1 mutations have previously been described in AF, yet this is the first time a mutation in KCNQ1 is associated with age-dependent bradycardia and persistent AF."
23989646
sparser
"Mutations in the IKs channel leading to gain-of-function have previously been described in familial AF, yet this is the first time a loss-of-function mutation in KCNQ1 is associated with early-onset lone AF."
25786344
sparser
"Interestingly, a cluster of gain of function KCNQ1 mutation that are associated with AF (S140G, V141M, Q147R) are located in this part of S1."
22529812
KCNH2 binds KCNJ2, KCNQ1, and PSMD4. 2 / 2
| 2
sparser
"In addition, AF has been associated with rare gain of function mutations in KCNQ1, hERG and KCNJ2 causing the short QT syndrome and sudden death."
16887036
sparser
"This is largely due to reduced L-type Ca 2+ current, although rare gain-of-function mutations in KCNQ1 [ xref ], hERG [ xref ], Kir2.1 [ xref ] and KCNE ancillary subunits [ xref ] have also been associated with AF due to increases in channel conductance."
20670193
KCNE2 binds KCNQ1 and PSMD4. 1 / 1
| 1
sparser
"Mutations in KCNE2 and/or KCNQ1 have previously been associated with LQTS, AF, and even early-onset myocardial infarction ( xref ; xref ; xref ; xref ; xref ), each of which is also predisposed to by thyroid dysfunction in the general population ( xref ; xref ; xref ), suggesting the intriguing possibility of an endocrine component to some KCNE2- and KCNQ1-associated human cardiac disease."
20688187
PSMD4 activates KCNQ1.
| 6
PSMD4 activates KCNQ1. 3 / 3
| 3
reach
"A whole-genome scan with polymorphic microsatellite markers and linkage analysis mapped the AF susceptibility loci on human chromosomes 10q22, 6q14-16, 11p15.5, 5p15, 10p11-q21, and 5p13, for which the AF causing mutations in 2 genes, KCNQ1 on chromosome 11p15.5 and NUP155 on chromosome 5p13, were identified and functionally characterized."
24473555
reach
"The initial AF causing mutation in KCNQ1 was identified by a positional candidate gene approach, whereas other ion-channel genes associated with AF were identified by the candidate gene approach in sporadic patients or small nuclear families (Wang, 2008)."
19070573
reach
"Following genome-wide linkage analysis with polymorphic genetic markers, specific susceptibility loci for AF have been mapped to human chromosomes 10q22, 6q14-16, 11p15.5, 5p15, 10p11-q21, and 5p13, and AF causing mutations in two genes, KCNQ1 on chromosome 11p15.5 and NUP155 on chromosome 5p13, have been identified and characterized."
23295592
PSMD4 activates KCNQ1-V1414M. 1 / 1
| 1
reach
"For example, expression of an early-onset AF causing potassium channel mutation KCNQ1 (V1414M) in Xenopus oocytes demonstrated a novel gain-of-function mechanism responsible for shortening of atrial and ventricular action potentials."
28734984
PSMD4 activates KCNQ1-S140G. 1 / 1
| 1
reach
"Thus, the mutation cosegregated with both AF and SVR.The transgenic mice overexpressing the human KCNQ1 S140G mutation suffered from frequent episodes of first-, second-, advanced-, and third-degree AVBs, while the wild-type transgenic mice with similar transgene expression levels exhibited no AVBs."
17467630
PSMD4 activates mutated KCNQ1. 1 / 1
| 1
reach
"For example, expression of an early-onset AF causing potassium channel mutation KCNQ1 (V1414M) in Xenopus oocytes demonstrated a novel gain-of-function mechanism responsible for shortening of atrial and ventricular action potentials."
28734984
Pyraclofos affects KCNQ1
| 1 15
Pyraclofos activates KCNQ1.
| 1 12
Pyraclofos activates KCNQ1. 13 / 13
| 1 12
reach
"Four residues in the transmembrane domain of the KCNE5 protein were found to be important for the control of the voltage dependent activation of the KCNQ1 current."
12324418
reach
"In this brief review we will discuss the current evidence regarding the mechanism by which KCNE1 regulates the voltage dependent activation of KCNQ1 as the best understood example of KCNE regulation of K V channel gating."
22529812
reach
"These structural models do not identify the likely mechanism for how KCNE1 modulates the voltage dependent activation of KCNQ1 as the interactions with the VSD, PGD, and S4/S5 linker suggest that regulation of VSD movement, PGD opening, and electromechanical coupling are all plausible."
22529812
reach
"In summary, our study demonstrates that KCNE1 alters the kinetics and voltage dependence of voltage sensor activation and channel opening of KCNQ1 channels."
24769622
reach
"KCNE3 acts by promoting voltage sensor activation in KCNQ1."
26668384
reach
"Together our findings suggest that altered charge-pair interactions within the voltage sensor module of KCNQ1 subunits may account for slowed I (Ks) deactivation induced by S140 or V141."
18599533
sparser
"The voltage-activated K + channel Kv7.1, previously called KvLQT1, is expressed in several tissues, including the heart, kidney and cells in the inner ear lateral wall."
25705178
reach
"Here we show that KCNE5 induces both a time- and voltage dependent modulation of the KCNQ1 current."
12324418
reach
"In addition, it has been shown that voltage sensor activation in KCNQ1 proceeds through an intermediate step before reaching full activation XREF_BIBR."
28383569
reach
"XREF_BIBR The KCNQ1 gene codifies KVLQT1 (Kv7.1), a voltage activated potassium channel alpha-subunit expressed in various cell types, including cardiac myocytes."
28491547
reach
"KCNE5 induces time- and voltage dependent modulation of the KCNQ1 current."
12324418
reach
"During a depolarizing voltage pulse that activates KCNQ1 channels, a fast decaying current following a brief hyperpolarization has been typically viewed as evidence of KCNQ1 channel inactivation."
29167462
reach
"Phe applications strongly facilitated voltage dependent activation of KCNQ1 and KCNE1 channels (= ~ -20 mV in V 1/2) and increased the maximal conductance over 2-fold compared to the current with no Phe application (XREF_FIG)."
25479336
Pyraclofos inhibits KCNQ1.
| 3
Pyraclofos inhibits KCNQ1. 3 / 3
| 3
reach
"Voltage dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunits."
9625865
reach
"The voltage dependent block of KCNQ1 current produced by external Ba 2+ was significantly attenuated in 50 mM [K +] 0, as measured in steady-state experiments."
15226366
reach
"Channels Gene Protein Mechanism Phenotype Voltage gated Potassium HERG Cardiac delayed rectifier Dominant negative loss of function Episodic cardiac arrhythmias (LOT) (h (r) with reduced repolarizing current KVLQT1?"
8791523
PKC affects KCNQ1
| 1 14
PKC phosphorylates KCNQ1.
| 1 13
PKC phosphorylates KCNQ1. 5 / 5
| 1 4
reach
"Human beta (3)-adrenoreceptors couple to KvLQT1 and MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein."
12879210
sparser
"Our results suggest that the regulation of the KvLQT1/MinK potassium channel via beta(3)-AR is substantially mediated by PKC phosphorylation of the KvLQT1 protein at its four C-terminal PKC phosphorylation sites."
12879210
reach
"In addition, it has been postulated that by directly phosphorylating four putative C-terminals PKC phosphorylation sites of KCNQ1, PKC increases the current amplitude [45]."
29452158
reach
"Our results suggest that the regulation of the KvLQT1 and MinK potassium channel via beta (3)-AR is substantially mediated by PKC phosphorylation of the KvLQT1 protein at its four C-terminal PKC phosphorylation sites."
12879210
reach
"Experiments in which the putative C-terminal PKC phosphorylation sites in the KvLQT1 protein were destroyed by site directed mutagenesis reduced the isoproterenol induced current to 27 +/-3,5% compared to control."
12879210
PKC phosphorylates KCNQ1 on S291. 1 / 1
| 1
reach
"Nine potential PKC phosphorylation sites in KCNQ1 (S95, T96, T247, S291, T391, S409, S464, T513 and S577) and one site in KCNE1 (S102) with high probability were predicted by KinasePhos 2.0."
29452158
PKC phosphorylates KCNQ1 on T247. 1 / 1
| 1
reach
"Nine potential PKC phosphorylation sites in KCNQ1 (S95, T96, T247, S291, T391, S409, S464, T513 and S577) and one site in KCNE1 (S102) with high probability were predicted by KinasePhos 2.0."
29452158
PKC phosphorylates KCNQ1 on S464. 1 / 1
| 1
reach
"Nine potential PKC phosphorylation sites in KCNQ1 (S95, T96, T247, S291, T391, S409, S464, T513 and S577) and one site in KCNE1 (S102) with high probability were predicted by KinasePhos 2.0."
29452158
PKC phosphorylates KCNQ1 on S409. 1 / 1
| 1
reach
"Nine potential PKC phosphorylation sites in KCNQ1 (S95, T96, T247, S291, T391, S409, S464, T513 and S577) and one site in KCNE1 (S102) with high probability were predicted by KinasePhos 2.0."
29452158
PKC phosphorylates KCNQ1 on S95. 1 / 1
| 1
reach
"Nine potential PKC phosphorylation sites in KCNQ1 (S95, T96, T247, S291, T391, S409, S464, T513 and S577) and one site in KCNE1 (S102) with high probability were predicted by KinasePhos 2.0."
29452158
PKC phosphorylates KCNQ1 on S577. 1 / 1
| 1
reach
"Nine potential PKC phosphorylation sites in KCNQ1 (S95, T96, T247, S291, T391, S409, S464, T513 and S577) and one site in KCNE1 (S102) with high probability were predicted by KinasePhos 2.0."
29452158
PKC phosphorylates KCNQ1 on T391. 1 / 1
| 1
reach
"Nine potential PKC phosphorylation sites in KCNQ1 (S95, T96, T247, S291, T391, S409, S464, T513 and S577) and one site in KCNE1 (S102) with high probability were predicted by KinasePhos 2.0."
29452158
PKC phosphorylates KCNQ1 on T96. 1 / 1
| 1
reach
"Nine potential PKC phosphorylation sites in KCNQ1 (S95, T96, T247, S291, T391, S409, S464, T513 and S577) and one site in KCNE1 (S102) with high probability were predicted by KinasePhos 2.0."
29452158
PKC phosphorylates KCNQ1 on T513. 1 / 1
| 1
reach
"Nine potential PKC phosphorylation sites in KCNQ1 (S95, T96, T247, S291, T391, S409, S464, T513 and S577) and one site in KCNE1 (S102) with high probability were predicted by KinasePhos 2.0."
29452158
PKC activates KCNQ1.
| 1
PKC activates KCNQ1. 1 / 1
| 1
reach
"Our results are consistent with a previous report that PKC enhances KCNQ1 and KCNE1 current through C-terminus phosphorylation sites of KCNQ1 in Xenopus oocytes [45]."
29452158
Phosphatidylinositol phosphate affects KCNQ1
| 7 7
Phosphatidylinositol phosphate binds KCNQ1. 8 / 8
| 6 2
reach
"It is not yet known whether KCNE3 has similar effects, but all members of the KCNE family possess similar residues to those important for modifying the manner in which PIP 2 interacts with KCNQ1 60."
26410412
sparser
"Thus, for R366Q and R555C mutant channels, regulation of the channel by PIP 2 was potentiated, suggesting that PKA and PKC activate the channel by strengthening KCNQ1 interactions with PIP 2 ."
22787448
sparser
"We previously identified a cluster of basic residues in the proximal C-terminus of KCNQ1 that form a PIP 2 /phosphoinositide binding site."
29020060
sparser
"Analyzing the average number of salt bridges for prolonged trajectories (additional 20 and 40 ns), we have found similar interactions between Kv7.1 and PIP 2 (see xref ), indicating that the performed simulations have converged within the 100 ns time scale."
25559286
sparser
"Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP 2 ."
24681627
sparser
"Regarding KCNQ1, we have shown that type 1 long QT (LQT1) syndrome can be associated with a decrease in KCNQ1-PIP 2 interactions provoked by mutations in the S4–S5 linker (R243H) and in the C-terminal domain CTD (R539W and R555C) xref ."
24681627
reach
"It is not yet known whether KCNE3 has similar effects, but all members of the KCNE family possess similar residues to those important for modifying the manner in which PIP 2 interacts with KCNQ1 (Li et al., 2011)."
26410412
sparser
"Among all lipids, four PIP 2 molecules interacted with several positive residues of Kv7.1 simultaneously, consistent with strong binding of PIP 2 to the channel."
25559286
Phosphatidylinositol phosphate binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"Similarly, mutations in Kv7.1 or KCNE1 that lead to a reduction in Kv7.1-PIP 2 affinity have been associated with congenital LQTS [114,136,137] ."
27818172
Phosphatidylinositol phosphate activates KCNQ1. 5 / 5
| 5
reach
"The role of PIP 2 modulation of native cardiac KCNQ1 channels is less well established."
24904429
reach
"In this configuration, hERG and KCNQ1 biophysical changes induced by PIP 2 insertion are quite similar (slowed deactivation with no effect on activation)."
20712994
reach
"Here we show that the auxiliary subunit of I (Ks), KCNE1, increases PIP (2) sensitivity 100-fold over channels formed by the pore forming KCNQ1 subunits alone, which effectively amplifies current because native PIP (2) levels in the membrane are insufficient to activate all KCNQ1 channels."
21576493
reach
"KCNQ1 and KCNE1, KCNQ4, and KCNQ5 channels are also reactivated by PIP 2 after inhibition by polylysine, showing that all KCNQ family members are PIP 2 sensitive."
22787448
reach
"The results indicate that PIP (2) indirectly activates hepatocellular KCNQ1 like channels via cytoskeletal rearrangement involving PKC activation."
16452155
Barium(2+) affects KCNQ1
| 13
Barium(2+) inhibits KCNQ1.
| 9
Barium(2+) inhibits KCNQ1. 9 / 9
| 9
reach
"In low external K + (2 mM), extracellular Ba 2+ produced a time dependent inhibition of homomeric KCNQ1 K + currents when expressed in Xenopus oocytes."
15226366
reach
"When measured upon a 3-s test potential at +30 mV and from a -60-mV tail potential, 10 mM Ba 2+ reduced by ~ 61% the fractional inactivation of KCNQ1 from 0.54 +/- 0.07 to 0.21 +/- 0.03 (n = 7) with an EC 50 = 0.94 +/- 0.07 mM (XREF_FIG C)."
15226366
reach
"For example, 10 mM Ba 2+ blocked at -20 mV the KCNQ1 K + currents with fast and slow time constants tau f = 220 +/- 43 ms and tau s = 1,073 +/- 128 ms, respectively (n = 8) (XREF_FIG B)."
15226366
reach
"Under these conditions, the KCNQ1 current was blocked by 51 +/- 7% (n = 6) at the beginning of the depolarizing step (at 200 ms) and by 31 +/- 3% (n = 6) at the end of the pulse (at 2,000 ms), thus providing strong evidence that barium could block KCNQ1 channels in the closed state."
15226366
reach
"Like with many K + channels, Ba 2+ block of KCNQ1 currents was voltage dependent, with weaker inhibition at depolarized potentials (XREF_FIG B and 11 B)."
15226366
reach
"For example, at +30 mV 10 mM Ba 2+ led to a 54 +/- 2% block of KCNQ1 outward currents in 50 mM [K +] 0, compared with a 72 +/- 3% inhibition in 2 mM [K +] 0 (P < 0.01, n = 10; XREF_FIG and XREF_FIG)."
15226366
reach
"The delta value obtained for the deep slow site of Ba 2+ block of KCNQ1 is similar to that found for Shaker K + channels (delta = 0.35), but is lower than that obtained for the high affinity Ba 2+ block of the inward-rectifier Kir2.1 channels (delta = 0.62) or that found for the two-pore domain K + channel KCNK0 (delta = 0.60)."
15226366
reach
"Barium also blocked KCNQ1 channels in the closed state."
15226366
reach
"Barium produced a marked slowing of KCNQ1 activation kinetics that is well seen at all potentials (XREF_FIG A and 6)."
15226366
Barium(2+) activates KCNQ1.
| 4
Barium(2+) activates KCNQ1. 4 / 4
| 4
reach
"On the other hand, inhibition of inactivation gating by Ba 2+ in low external K + can not be accounted for by a general slowing of the sequential gating XREF_FIG, since very long depolarizing pulses (+30 mV for 6 min) performed in the presence of 4 mM Ba 2+ did not restore KCNQ1 inactivation, as measured by the hooked tail currents (unpublished data)."
15226366
reach
"The voltage dependent block of KCNQ1 current produced by external Ba 2+ was significantly attenuated in 50 mM [K +] 0, as measured in steady-state experiments."
15226366
reach
"Third, high external K + prevented the slowing of KCNQ1 activation kinetics produced by Ba 2+ (XREF_FIG A)."
15226366
reach
"Second, high external K + (50 mM) prevented the slowing of KCNQ1 activation produced by 10 mM Ba 2+, though Ba 2+ washout kinetics were even slower in 50 mM [K +] 0 than in 2 mM [K +] 0 (XREF_FIG A, XREF_TABLE and see below)."
15226366
KCNQ1OT1 affects KCNQ1
| 11 2
KCNQ1OT1 binds KCNQ1.
| 11
KCNQ1 binds KCNQ1OT1. 8 / 8
| 8
sparser
"Using two complementary approaches, we demonstrate that Kcnq1ot1 lncRNA interacts directly with chromatin to form a 200-kb intrachromosomal loop between the downstream Kcnq1 promoter and the KvDMR1where the Kcnq1ot1 promoter is located."
24395636
sparser
"In both the wild-type cells and in cells in which the deletion was maternally inherited ( xref , −(M)/+), we detected interactions of Kcnq1ot1 noncoding RNA with the Kcnq1 promoter DNA ( xref , D2/Rb) and with KvDMR1 ( xref , left, lanes 1–3, D5/Rb)."
24395636
sparser
"Using R3C, we show that in both the wild-type and control shRNA cells (shK1, shH19, and shNespas), Kcnq1ot1 directly interacted with the Kcnq1 promoter ( xref , D2/Rb) and KvDMR1 ( xref , D5/Rb)."
24395636
sparser
"Using this SNP to separate the allelic R3C products, we found that Kcnq1ot1 lncRNA interacted exclusively with the paternal Kcnq1 promoter ( xref , bottom, lanes 1 and 2)."
24395636
sparser
"We detected the direct interaction of Kcnq1ot1 noncoding RNA (Ra and Rb sites) with both the Kcnq1 promoter (D1 and D2 sites; xref , left, lanes 1 and 2) and the Kcnq1 ICR (KvDMR1; D5 and D6 sites; xref , right, lanes 5 and 6)."
24395636
sparser
"Using R3C, we show that in MBW2 control cells, Kcnq1ot1 directly interacted with the Kcnq1 promoter ( xref , left, lanes 1 and 2)."
24395636
sparser
"Collectively, our data from these three distinct models demonstrate an allele-specific interaction between the Kcnq1ot1 lncRNA and KvDMR1– Kcnq1 promoter DNA regions."
24395636
sparser
"Because Kcnq1ot1 lncRNA interacts with both the Kcnq1 promoter and the KvDMR1, which are 200 kb apart, we hypothesized that the Kcnq1ot1 lncRNA scaffolds these long-distance DNA regions to form an intrachromosomal structure, which is critical for the maintenance of allelic expression of genes in this imprinted region."
24395636
KCNQ1 binds KCNQ1OT1 and IC2. 1 / 1
| 1
sparser
"In the mouse, targeted deletion of the orthologous IC2 region results in growth restriction and loss of imprinting of six genes including Cdkn1c and Phlda2 when paternally inherited. xref By contrast, paternal transmission of 250–330 kb deletions, including most of the KCNQ1 gene, IC2 and KCNQ1OT1 is associated with normal phenotype in humans (refs. xref and xref ; also see xref )."
23243085
PRC2_complex binds EHMT2, KCNQ1, and KCNQ1OT1. 1 / 1
| 1
sparser
"Kcnq1ot1 interacts with PRC2 as well as the H3K9-specific histone methyltransferase G9a in a lineage-specific manner to mediate the silencing of the Kcnq1 gene in the paternal allele in placenta ( xref )."
24342564
CD81 binds KCNQ1, KCNQ1OT1, and ASCL2. 1 / 1
| 1
sparser
"This is indeed the case, as we not only found significant enrichment of heterochromatin modifications in the overlapping Kcnq1-Cd81-Ascl2 region but also specific interaction of Kcnq1ot1 with Kcnq1 , Cd81 , and Ascl2 gene regions in comparison to the other regions in the Kcnq1 domain."
18951091
KCNQ1OT1 decreases the amount of KCNQ1.
| 1
KCNQ1OT1 decreases the amount of KCNQ1. 1 / 1
| 1
reach
"Lack of maternal methylation of KvDMR1 permits expression of an antisense transcript (KCNQ1OT1) which reduces expression of the KCNQ1 and CDKN1C genes, and this is observed in about half of BWS cases."
20639793
KCNQ1OT1 activates KCNQ1.
| 1
KCNQ1OT1 activates KCNQ1. 1 / 1
| 1
reach
"Kcnq1 was negatively mediated by KCNQ1OT1 via DNMT1."
31454677
KCNQ1 affects JLNS
| 12
KCNQ1 activates JLNS.
| 11
KCNQ1 activates JLNS. 8 / 8
| 8
reach
"JLNS is a ventricular repolarization abnormality and is caused by mutations in the KCNQ1 or KCNE1 gene."
26022593
reach
"Several missense variants are reported to cause RWS by a dominant negative mechanism, and some KCNQ1 variants can cause both Jervell and Lange-Nielsen Syndrome (JLNS; in an autosomal recessive manner) and LQTS1 (in an autosomal dominant manner), while other KCNQ1 variants cause only JLNS."
28595573
reach
"Novel compound heterozygous nonsense mutations in C-terminus of KCNQ1 can cause JLNS."
14510661
reach
"JLNS is also caused by mutations in KCNQ1, although it is a recessive disorder whereas LQT1 is an autosomal dominant or sporadic disease."
28883014
reach
"In summary, some KCNQ1 variants can cause both JLNS (in an autosomal recessive manner) and RWS (in an autosomal dominant manner), while several KCNQ1 variants cause only JLNS in an autosomal recessive manner."
28595573
reach
"In this report we provide evidence that not only homozygous but also compound heterozygous mutations in KvLQT1 may cause JLNS in nonconsanguineous families."
12051962
reach
"To the best of our knowledge, this is the first report showing that a nonsense variant in exon 1a of KCNQ1, which is the kidney-isoform specific exon, causes JLNS."
28595573
reach
"Here, we report a novel nonsense KCNQ1 variant causing not only JLNS, but also significant QTc prolongation identical to RWS in an autosomal dominant manner."
28595573
Mutated KCNQ1 activates JLNS. 3 / 3
| 3
reach
"The disruption of potassium secretion into the endolymph of the inner ear in JLNS by knockout or mutation of MinK is accepted to be due to dysfunction of MinK-KCNQ1 complexes in the ear, especially as KCNQ1 mutations can also cause JLNS, but the LQTS component could be also caused by dysfunction of other channels that MinK may associate with in the heart, including ERG."
19219384
reach
"A novel homozygous KVLQT1 mutation causes JLNS in an Amish family with deafness that is inherited as an autosomal recessive trait."
10077519
reach
"The results expand the spectrum of KCNQ1 mutations causing RWS and JLNS."
18400097
KCNQ1 inhibits JLNS.
| 1
KCNQ1 inhibits JLNS. 1 / 1
| 1
reach
"It is reasonable to conclude that dominant negative KCNQ1 variants can cause both RWS and JLNS."
28595573
KCNQ1 affects cell death
| 11
KCNQ1 activates cell death. 10 / 10
| 10
reach
"We report, for a first time, a KCNQ1 mutation in a family suffering of both phenotypes, suggesting that KCNQ1 genetic variations may confer susceptibility for recurrent seizure activity increasing the risk or lead to sudden death."
25645639
reach
"Mutations of the human KCNQ1 gene are associated with the congenital long-QT syndrome and increases the risk of sudden death from cardiac arrhythmias."
28955952
reach
"Paradoxically, gain-of-function mutations in KCNQ1 have been reported to cause borderline QT prolongation, atrial fibrillation (AF), sinus bradycardia, and sudden death, however, the mechanisms are not well understood."
30967788
reach
"Beginning with the finding that SCN5A, a sodium channel gene associated with cardiac long QT syndrome (LQTS) linked to sudden death, is expressed in the amygdala, the limbic nucleus regulating cardiac representation in the forebrain 45, mutations in the human gene encoding the KCNQ1 potassium channel (the most common cause of human LQTS and sudden death) were evaluated in mouse models and shown to replicate the SUDEP phenotype 46, opening the door to many LQT genes as candidates for shared brain and cardiac arrhythmia."
25710836
reach
"Recessive mutations in the ion channel encoding KCNQ1 gene may cause Jervell and Lange-Nielsen syndrome (JLNS), a fatal cardiac disease leading to arrhythmia and sudden cardiac death in young patients."
26481773
reach
"Long QT syndrome 1 (LQT1) mutations in KCNQ1 that decrease cardiac IKs (slowly activating delayed rectifier K (+) current) underlie ventricular arrhythmias and sudden death."
25344363
reach
"While LQT1 is transmitted in an autosomal dominant manner, homozygous or compound heterozygous mutations in KCNQ1 or the beta-subunit KCNE1 cause the Jervell and Lange-Nielsen syndrome (JLNS), which has a autosomal recessive pattern of inheritance and is associated with severe life threatening cardiac arrhythmias, a high risk of sudden death due to ventricular tachycardia, and congenital bilateral deafness [XREF_BIBR, XREF_BIBR]."
28721524
reach
"Mechanisms governing which channel types prevail have not previously been reported, despite their significance : normal cardiac rhythm requires tight control of IKs density and kinetics, and inherited mutations in KCNQ1 and MinK can cause ventricular fibrillation and sudden death."
19202166
reach
"In summary, although our family does not necessarily provide the definite evidence for a link between LQTS and epilepsy, it further supports the view that KCNQ1 genetic variations may confer susceptibility for recurrent seizure activity increasing the risk or lead to sudden death, according to the cardiocerebral channelopathy theory [11,17]."
25645639
reach
"Accordingly, defective KCNE1 and/or KCNQ1 lead to long QT syndrome, a disorder causing fainting and sudden cardiac death."
15107590
KCNQ1-S140G activates cell death. 1 / 1
| 1
reach
"This suggests that the KCNQ1 S140G mutation increases the risk of death by sudden cardiac arrest."
30108508
KCNQ1 affects KCNQ1OT1
| 11
KCNQ1 binds KCNQ1OT1. 8 / 8
| 8
sparser
"Using two complementary approaches, we demonstrate that Kcnq1ot1 lncRNA interacts directly with chromatin to form a 200-kb intrachromosomal loop between the downstream Kcnq1 promoter and the KvDMR1where the Kcnq1ot1 promoter is located."
24395636
sparser
"In both the wild-type cells and in cells in which the deletion was maternally inherited ( xref , −(M)/+), we detected interactions of Kcnq1ot1 noncoding RNA with the Kcnq1 promoter DNA ( xref , D2/Rb) and with KvDMR1 ( xref , left, lanes 1–3, D5/Rb)."
24395636
sparser
"Using R3C, we show that in both the wild-type and control shRNA cells (shK1, shH19, and shNespas), Kcnq1ot1 directly interacted with the Kcnq1 promoter ( xref , D2/Rb) and KvDMR1 ( xref , D5/Rb)."
24395636
sparser
"Using this SNP to separate the allelic R3C products, we found that Kcnq1ot1 lncRNA interacted exclusively with the paternal Kcnq1 promoter ( xref , bottom, lanes 1 and 2)."
24395636
sparser
"We detected the direct interaction of Kcnq1ot1 noncoding RNA (Ra and Rb sites) with both the Kcnq1 promoter (D1 and D2 sites; xref , left, lanes 1 and 2) and the Kcnq1 ICR (KvDMR1; D5 and D6 sites; xref , right, lanes 5 and 6)."
24395636
sparser
"Using R3C, we show that in MBW2 control cells, Kcnq1ot1 directly interacted with the Kcnq1 promoter ( xref , left, lanes 1 and 2)."
24395636
sparser
"Collectively, our data from these three distinct models demonstrate an allele-specific interaction between the Kcnq1ot1 lncRNA and KvDMR1– Kcnq1 promoter DNA regions."
24395636
sparser
"Because Kcnq1ot1 lncRNA interacts with both the Kcnq1 promoter and the KvDMR1, which are 200 kb apart, we hypothesized that the Kcnq1ot1 lncRNA scaffolds these long-distance DNA regions to form an intrachromosomal structure, which is critical for the maintenance of allelic expression of genes in this imprinted region."
24395636
KCNQ1 binds KCNQ1OT1 and IC2. 1 / 1
| 1
sparser
"In the mouse, targeted deletion of the orthologous IC2 region results in growth restriction and loss of imprinting of six genes including Cdkn1c and Phlda2 when paternally inherited. xref By contrast, paternal transmission of 250–330 kb deletions, including most of the KCNQ1 gene, IC2 and KCNQ1OT1 is associated with normal phenotype in humans (refs. xref and xref ; also see xref )."
23243085
PRC2_complex binds EHMT2, KCNQ1, and KCNQ1OT1. 1 / 1
| 1
sparser
"Kcnq1ot1 interacts with PRC2 as well as the H3K9-specific histone methyltransferase G9a in a lineage-specific manner to mediate the silencing of the Kcnq1 gene in the paternal allele in placenta ( xref )."
24342564
CD81 binds KCNQ1, KCNQ1OT1, and ASCL2. 1 / 1
| 1
sparser
"This is indeed the case, as we not only found significant enrichment of heterochromatin modifications in the overlapping Kcnq1-Cd81-Ascl2 region but also specific interaction of Kcnq1ot1 with Kcnq1 , Cd81 , and Ascl2 gene regions in comparison to the other regions in the Kcnq1 domain."
18951091
KCNQ1 affects KCN
| 1 8 3
KCNQ1 binds KCN.
| 1 8
KCN binds KCNQ1. 2 / 2
| 1 2
sparser
"In a heterozygote, wild type and defective monomers can co-assemble to form an impaired KCNQ1 potassium channel complex, which can result in a prolonged QT interval ( xref ; xref )."
30461122
sparser
"MinK is a potassium channel subunit which co-assembles with KvLQT1 to form the slowly activated, delayed rectifier K current that plays an important role in cardiac depolarization( xref ; xref )."
25442735
KCN binds KCNE2 and KCNQ1. 2 / 2
| 2
sparser
"Here, we show that the potassium channel subunits KCNQ1 and KCNE2 form a thyroid-stimulating hormone-stimulated, constitutively active, thyrocyte K+ channel required for normal thyroid hormone biosynthesis."
19767733
sparser
"Kcne2 colocalized and coimmunoprecipitated with Kcnq1 in mouse lungs, suggesting the formation of pulmonary Kcnq1-Kcne2 potassium channel complexes."
31162977
KCN binds KCNE1 and KCNQ1. 2 / 2
| 2
sparser
"Genetic defect is located in the KCNQ1 and KCNE1 (LQT1) genes that form the slow component of the delayed rectifier potassium channel complex (90 and 10% of cases, resp.)."
22013448
sparser
"KvLQT1 and minK associate to form the functional slowly activated delayed rectifier potassium channel ( I Ks ) [12,13] while HERG and MiRP1 associate to form the rapidly activated delayed rectifier potassium channel ( I Kr ) [10] ."
12051962
KCN binds KCNE3 and KCNQ1. 1 / 1
| 1
sparser
"The Kv7.1 protein may be also associated with MiRP2 protein to form the potassium channel ( xref )."
30420954
KCN binds KCNE1, KCNE3, and KCNQ1. 1 / 1
| 1
sparser
"The KCNQ1 gene, encodes the Kv7.1 channel protein, which can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. xref In the human heart the KCNQ1 encodes the pore-forming α subunit, and KCNE1 (also known as minK) encodes the regulatory β subunit of the KCNQ1- KCNE1 complex responsible for I Ks , the slowly activating delayed rectifier K + repolarizing current. xref Mutations in KCNQ1 are associated with hereditary LQTS1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. xref In 2002, Marx et al showed that modulation of I KS β-adrenergic receptor stimulation requires targeting of cyclic adenosine 3′,5′-monophosphate (cAMP)–dependent PKA and protein phosphatase 1 (PP1) to hKCNQ1 through the A kinase-anchoring protein (AKAP)-9, also known as yotiao. xref These authors elegantly demonstrated that yotiao binds to the human KCNQ1 by a leucine zipper motif, which is disrupted by an LQTS mutation (hKCNQ1-G589D)."
26044251
KCNQ1 activates KCN.
| 3
KCNQ1 activates KCN. 3 / 3
| 3
reach
"E2 (100 nM) reduced the currents mediated by the KCNQ1 : KCNE3 potassium channel and had no effect on currents via KCNQ1 : KCNE1 or KCNQ1 alone."
21911611
reach
"XREF_BIBR, XREF_BIBR Rare mutations in KCNQ1 are known to cause potassium channel dysfunction leading to a form of cardiac long QT syndrome (LQT1) and serious arrhythmias, ventricular fibrillation and cardiac arrest."
22151254
reach
"1 It is caused by mutations in the KCNQ1 gene that impair the slow acting potassium channel that gives rise to I Ks."
22293141
USP2 affects KCNQ1
2 | 1 2 6
USP2 binds KCNQ1.
2 | 2 2
USP2 binds KCNQ1. 6 / 6
2 | 2 2
sparser
"Whether or not Nedd4-2 is coexpressed does not seem to influence the binding of USP2 to KCNQ1, as both USP2-45 and USP-69 bind equally well under the 2 conditions ( Figure 3 )."
22024150
biogrid
No evidence text available
22024150
reach
"Coimmunoprecipitation assays suggested that USP2 can bind to KCNQ1 independently of the PY motif."
22024150
sparser
"Coimmunoprecipitation assays suggested that USP2 can bind to KCNQ1 independently of the PY motif."
22024150
reach
"A reduced level of ubiquitylation leads to an increased surface density of KCNQ1 channels and thereby explains the rescued current level observed in the functional experiments.Whether or not Nedd4-2 is coexpressed does not seem to influence the binding of USP2 to KCNQ1, as both USP2-45 and USP-69 bind equally well under the 2 conditions."
22024150
biogrid
No evidence text available
22024150
USP2 activates KCNQ1.
| 1 2
USP2 activates KCNQ1. 2 / 2
| 1 2
reach
"Immunocytochemistry confirmed that USP2 restores the membrane localization of KCNQ1."
22024150
reach
"In contrast to previous observations with the ENaC, coexpression of the 2 isoforms of USP2 in the present study did not increase the KCNQ1 and KCNE1 mediated current in Xenopus oocytes per se."
22024150
USP2 inhibits KCNQ1.
| 1
USP2 inhibits KCNQ1. 1 / 1
| 1
reach
"Having found that USP2 antagonized the Nedd4-2-mediated downregulation of KCNQ1, we aimed to test whether USP2 interacted directly with the channel."
22024150
USP2 increases the amount of KCNQ1.
| 1
USP2 increases the amount of KCNQ1. 1 / 1
| 1
reach
"The catalytically inactive USP2 (CA) did not restore the KCNQ1 level."
22024150
NEDD4L affects KCNQ1
2 | 4 2 6
NEDD4L binds KCNQ1.
2 | 2 2 1
KCNQ1 binds NEDD4L. 5 / 5
2 | 2 2 1
reach
"The ubiquitin ligase Nedd4.2 binds KCNQ1 in response to E2 to induce channel internalization."
23529131
sparser
"The ubiquitin ligase Nedd4.2 binds KCNQ1 in response to E2 to induce channel internalization."
23529131
biogrid
No evidence text available
23529131
sparser
"Furthermore, KCNQ1/KCNE1 complexes can be internalized by Nedd4.2-dependent ubiquitinylation, through direct interaction of Nedd4.2 with KCNQ1 ( xref ); this process was recently found to be regulated by the AMP-activated protein kinase (AMPK) ( xref )."
21699843
biogrid
No evidence text available
26405101
NEDD4L ubiquitinates KCNQ1.
| 2
NEDD4L ubiquitinates KCNQ1. 1 / 1
| 1
reach
"Nedd4-2 can also ubiquitinate the KCNQ1 potassium channel, resulting in KCNQ1 's removal from the cell surface, internalization and degradation by the proteasome [XREF_BIBR], a reaction that can be counteracted by the de-ubiquitinylating enzyme USP2 [XREF_BIBR]."
24262338
Modified NEDD4L leads to the ubiquitination of KCNQ1. 1 / 1
| 1
reach
"Coexpression of Nedd4-2 with KCNQ1 increased the ubiquitylation of KCNQ1."
22024150
NEDD4L inhibits KCNQ1.
| 1 1
NEDD4L inhibits KCNQ1. 1 / 1
| 1 1
reach
"Similarly, Nedd4-2 decreased KCNQ1 and KCNE1 mediated currents and KCNQ1 protein abundance in the cell membrane."
21231794
NEDD4L increases the amount of KCNQ1.
| 1
NEDD4L increases the amount of KCNQ1. 1 / 1
| 1
reach
"By performing Western blotting of the soluble fraction of lysed HEK cells, we observed a drastic reduction in the KCNQ1 protein level, which was caused by Nedd4-2."
22024150
NEDD4L decreases the amount of KCNQ1.
| 1 1
NEDD4L decreases the amount of KCNQ1. 1 / 1
| 1 1
reach
"As it has been recently shown that the ubiquitin protein ligase Nedd4-2 inhibits KCNQ1 plasma membrane expression and that AMPK regulates epithelial Na (+) channels via Nedd4-2, we examined the role of Nedd4-2 in the AMPK dependent regulation of KCNQ1."
20861072
KCNQ1 affects pyraclofos
| 10
KCNQ1 activates pyraclofos.
| 7
KCNQ1 activates pyraclofos. 5 / 5
| 5
reach
"In contrast, co-assembly of KCNQ1 and KCNE3 produces a current with nearly instantaneous activation, some time dependent activation at very positive potentials, and a linear current voltage relationship."
11448722
reach
"This different expression pattern of KCNQ1 isoforms in NCI-H295 cell line with the lack of the mRNA for the dominant negative KCNQ1 isoform 2 supports the involvement of voltage gated K+ channel in cell proliferation."
16610241
reach
"In mouse pancreatic acini KCNQ1 probably co-assembled with KCNE1 leads to a voltage dependent K (+) current that might be of importance for electrolyte and enzyme secretion."
11889581
reach
"In the heart, coassembly of KCNQ1 with KCNE1 elicits voltage- and time dependent K + currents (I KS) with very slow activation kinetics, a positive shift in the voltage dependence of activation, and an increase in unitary channel conductance, in comparison to homomeric KCNQ1 channels."
15226366
reach
"On one hand, voltage dependent KCNQ1 (KvLQT1) channels can coassemble with some members of the MiRP (KCNE) family of single transmembrane spanning proteins to produce a voltage independent K + current."
16446506
KCNQ1-S140G activates pyraclofos. 2 / 2
| 2
reach
"We show that KCNQ1 S140G directly slows voltage sensor deactivation which in turn slows current deactivation, whereas KCNQ1 V141M has minimal effect on channel gating."
28383569
reach
"Taken together, these experiments show that KCNQ1 S140G slows voltage sensor deactivation even in the absence of channel opening."
28383569
KCNQ1 inhibits pyraclofos.
| 3
KCNQ1 inhibits pyraclofos. 2 / 2
| 2
reach
"KCNE1 complexes with KCNQ1 to both slow its voltage stimulated activation and to enhance its open state conductance, resulting in the I Ks current of the cardiac action potential."
22085289
reach
"The time- and voltage dependent current had biophysical properties typical of cardiac KCNQ1 and KCNE1 current and was almost completely abolished by KCNQ1 blocker chromanol 293B (50 microM)."
19139916
KCNQ1-S140G inhibits pyraclofos. 1 / 1
| 1
reach
"As KCNQ1 S140G slows voltage sensor movement and current deactivation by a similar order of magnitude, but with a slightly greater effect on the voltage sensor, we explored whether KCNQ1 S140G slows voltage sensor movement when channel pore opening is prevented."
28383569
KCNQ1 affects phosphatidylinositol phosphate
| 7 3
Phosphatidylinositol phosphate binds KCNQ1. 8 / 8
| 6 2
reach
"It is not yet known whether KCNE3 has similar effects, but all members of the KCNE family possess similar residues to those important for modifying the manner in which PIP 2 interacts with KCNQ1 60."
26410412
sparser
"Thus, for R366Q and R555C mutant channels, regulation of the channel by PIP 2 was potentiated, suggesting that PKA and PKC activate the channel by strengthening KCNQ1 interactions with PIP 2 ."
22787448
sparser
"We previously identified a cluster of basic residues in the proximal C-terminus of KCNQ1 that form a PIP 2 /phosphoinositide binding site."
29020060
sparser
"Analyzing the average number of salt bridges for prolonged trajectories (additional 20 and 40 ns), we have found similar interactions between Kv7.1 and PIP 2 (see xref ), indicating that the performed simulations have converged within the 100 ns time scale."
25559286
sparser
"Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP 2 ."
24681627
sparser
"Regarding KCNQ1, we have shown that type 1 long QT (LQT1) syndrome can be associated with a decrease in KCNQ1-PIP 2 interactions provoked by mutations in the S4–S5 linker (R243H) and in the C-terminal domain CTD (R539W and R555C) xref ."
24681627
reach
"It is not yet known whether KCNE3 has similar effects, but all members of the KCNE family possess similar residues to those important for modifying the manner in which PIP 2 interacts with KCNQ1 (Li et al., 2011)."
26410412
sparser
"Among all lipids, four PIP 2 molecules interacted with several positive residues of Kv7.1 simultaneously, consistent with strong binding of PIP 2 to the channel."
25559286
Phosphatidylinositol phosphate binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"Similarly, mutations in Kv7.1 or KCNE1 that lead to a reduction in Kv7.1-PIP 2 affinity have been associated with congenital LQTS [114,136,137] ."
27818172
Mutated KCNQ1 inhibits phosphatidylinositol phosphate. 1 / 1
| 1
reach
"Other consequences of KCNQ1 mutations include altered protein trafficking, with subsequent reduction of cell surface expression, and reduced PIP 2 sensitivity."
29259974
KCNE5 affects KCNQ1
| 3 3 7
KCNE5 inhibits KCNQ1.
| 1 4
KCNE5 inhibits KCNQ1. 4 / 4
| 1 4
reach
"The KCNE5 gene product MiRP4 suppresses the IKs current and downregulates the beta-subunit of the KCNQ1."
23710137
reach
"At room temperature, KCNE5 slowed KCNQ1 activation to a rate half of that observed for KCNQ1-KCNE1 (XREF_FIG) and accelerated KCNQ1 deactivation."
27484720
reach
"At room temperature, KCNE5 slowed KCNQ1 activation to a rate half of that observed for KCNQ1-KCNE1 and accelerated KCNQ1 deactivation."
27484720
reach
"KCNE4 and KCNE5, in contrast, each inhibit KCNQ1 activity; in the case of KCNE4 this effect involves calmodulin but probably not impaired trafficking [XREF_BIBR - XREF_BIBR], while the KCNE5 effect involves a positive-shift in the voltage dependence of activation [XREF_BIBR]."
28718502
KCNE5 binds KCNQ1.
| 2 3
KCNE5 binds KCNQ1. 1 / 1
| 2 1
sparser
"From biochemical studies, KCNE2 to KCNE5 each can bind KCNQ1 and alter its channel properties ( xref ; xref )."
30461122
KCNE5 binds KCNE4 and KCNQ1. 1 / 1
| 1
sparser
"We have reported interaction of KCNE4 and KCNE5 with KCNQ1, providing modulations of the KCNQ1 current ( Grunnet et al., 2002a ; Angelo et al., 2002 )."
12944270
KCNE1 binds KCNE5, KCNE3, and KCNQ1. 1 / 1
| 1
sparser
"We determined inactivation properties and compared K+ vs. Rb+ inward currents for channels formed by co-assembly of KCNQ1 with KCNE1, KCNE3 and KCNE5, and for homomeric KCNQ1 channels with point mutations in the pore helix S5 or S6 transmembrane domains."
14561821
KCNE5 activates KCNQ1.
| 3
KCNE5 activates KCNQ1. 3 / 3
| 3
reach
"KCNE5 induces time- and voltage dependent modulation of the KCNQ1 current."
12324418
reach
"It does this without reducing the surface expression of KCNQ1 XREF_BIBR, XREF_BIBR, although it has been reported that KCNE4 (and KCNE5) prevent targeting of KCNQ1 to lipid rafts 53; KCNE4-KCNQ1 complexes are detectable in the plasma membrane when the two are co-expressed 51."
27484720
reach
"It does this without reducing the surface expression of KCNQ1 (Grunnet et al., 2002; Grunnet et al., 2005), although it has been reported that KCNE4 (and KCNE5) prevent targeting of KCNQ1 to lipid rafts (Roura-Ferrer et al., 2010); KCNE4-KCNQ1 complexes are detectable in the plasma membrane when the two are co-expressed (Grunnet et al., 2002)."
27484720
KCNQ1 affects glucose
| 9
KCNQ1 inhibits glucose.
| 4
KCNQ1 inhibits glucose. 4 / 4
| 4
reach
"It was found that chromanol 293B, a selective blocker of KCNQ1 expressed in IEC, can enhance glucose tolerance and glucose stimulated insulin secretion and plasma GLP-1 levels in cultured islets and intact animals [XREF_BIBR]."
26784222
reach
"Germline deletion of Kcnq1 increases glucose tolerance in mice [XREF_BIBR], whereas deletion of Kcne2 decreases glucose tolerance, decreases insulin sensitivity, and impairs insulin secretion in response to glucose [XREF_BIBR, XREF_BIBR]."
28718502
reach
"Previous studies have shown that KCNQ1 reduced glucose stimulated insulin secretion [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
26039078
reach
"In this study, we found that a KCNQ1 selective inhibitor (chromanol 293B) increased the uptake of extracellular glucose and activated the IRS-2/PI3K/Akt pathway in normal and IR HepG2 cells, indicating that KCNQ1 has a pivotal role in regulating insulin signal transduction pathways under both physiological and pathological conditions."
27857189
KCNQ1 activates glucose.
| 3
KCNQ1 activates glucose. 3 / 3
| 3
reach
"In mice, the deletion of the Kcnq1 gene leads to decreased non fasted plasma glucose and insulin concentrations (Boini et al., 2009)."
26970180
reach
"The present study explored the influence of KCNQ1 on insulin induced cellular K+ uptake and glucose metabolism."
19369585
reach
"2001), and in addition, it has been shown in mice that the knockout of KCNQ1 impairs the intestinal absorption of glucose and phenylalanine (Vallon etal."
27273883
KCNQ1 increases the amount of glucose.
| 2
Modified KCNQ1 increases the amount of glucose. 1 / 1
| 1
reach
"7 KCNE1 and KCNQ1 K + channel have been localized to the brush border of the mid to late proximal tubule in mouse, where they maintain the proximal tubule brush border membrane potential, and the loss of KCNQ1 and KCNE1 lead to urinary loss of Na + and glucose."
20353914
KCNQ1 increases the amount of glucose. 1 / 1
| 1
reach
"The study reported for the first time in Chinese population the KCNQ1 rs2237892 polymorphism plays an important role in risk of GDM and increased glucose levels."
26039078
KCNE proteins affects KCNQ1
| 9
KCNE proteins activates KCNQ1.
| 7
KCNE proteins activates KCNQ1. 7 / 7
| 7
reach
"Although the physiological context for the interaction of KCNE1 with KCNQ1 is generally appreciated, KCNQ1 may also be modulated by other KCNE proteins in vivo.Different KCNE proteins can modulate KCNQ1 channels to produce diverse biophysical phenotypes."
15698834
reach
"These accumulated data support the idea that KCNE proteins interact with the VSDs of KCNQ1 and modulate the gating of the KCNQ1 channel."
25603957
reach
"The mechanisms by which KCNE proteins modulate KCNQ1 channel activity are still being debated."
17698596
reach
"KCNQ1 channel modulation by KCNE proteins via the voltage sensing domain."
25603957
reach
"The mechanisms by which KCNE proteins modulate KCNQ1 channels have long been studied and discussed; however, it is not well understood how different KCNE proteins exert considerably different effects on KCNQ1 channels."
22042987
reach
"The observation that multiple KCNE proteins can co-associate with and modulate KCNQ1 channels to produce biochemically diverse channel complexes has important implications for understanding K (V) channel regulation in human physiology."
18279388
reach
"KCNE proteins target different parts of the KCNQ1 channel, and this may be the reason why the modulations by KCNE proteins are various."
22042987
KCNE proteins binds KCNQ1.
| 2
KCNQ1 binds KCNE proteins. 2 / 2
| 2
reach
"Although it has been known that KCNE proteins interact with KCNQ1 via the pore domain, some recent reports suggest that the VSD movement may be altered by KCNE."
25603957
reach
"XREF_BIBR, XREF_BIBR Heterologous expression experiments have demonstrated that KCNE proteins alter the properties of several K V channels, XREF_BIBR - XREF_BIBR and that all KCNE proteins (KCNE1-KCNE5) interact with KCNQ1 (K V 7.1), each yielding a distinct phenotype."
20139709
CTNNB1 affects KCNQ1
| 2 7
CTNNB1 binds KCNQ1.
| 2 3
CTNNB1 binds KCNQ1. 5 / 5
| 2 3
sparser
"Mechanistically, KCNQ1 can interact with β-catenin to affect its subcellular distribution and subsequently reduce the activity of Wnt/β-catenin signaling, which further blocks the expression of its downstream targets, including c-Myc, MMP7, and CCND1."
30144972
reach
"Bidirectional KCNQ1 : beta-catenin interaction drives colorectal cancer cell differentiation."
28373572
reach
"Mechanistically, KCNQ1 can interact with beta-catenin to affect its subcellular distribution and subsequently reduce the activity of Wnt and beta-catenin signaling, which further blocks the expression of its downstream targets, including c-Myc, MMP7, and CCND1."
30144972
sparser
"We investigated the molecular mechanisms regulating KCNQ1:β-catenin bidirectional interactions and their effects on CRC differentiation, proliferation, and invasion."
28373572
reach
"The present study explored the functional interaction of beta-catenin and KCNE1 and KCNQ1, the K+ channel complex underlying the slowly activating outwardly rectifying K+ current."
22583083
CTNNB1 activates KCNQ1.
| 3
CTNNB1 activates KCNQ1. 3 / 3
| 3
reach
"Beta-catenin has been shown to interact with and/or modulate the activity of large-conductance Ca 2+ -activated K + channels XREF_BIBR, kainate receptors XREF_BIBR, Kv1.5 K + channels XREF_BIBR and KCNQ1 and KCNE1 K + channels XREF_BIBR."
22905262
reach
"Confocal microscopy revealed that beta-catenin enhanced the KCNE1 and KCNQ1 protein abundance in the cell membrane."
22583083
reach
"In conclusion, beta-catenin enhances I (Ks) by increasing the KCNE1 and KCNQ1 protein abundance in the cell membrane, an effect requiring vesicle insertion into the cell membrane."
22583083
CTNNB1 inhibits KCNQ1.
| 1
CTNNB1 inhibits KCNQ1. 1 / 1
| 1
reach
"P4 : Beta catenin and TCF4 activation reduces KCNQ1 current in colonic monolayers."
| PMC
SGK1 affects KCNQ1
| 3 8
SGK1 activates KCNQ1. 7 / 7
| 3 7
reach
"Moreover, SGK1 could stimulate proximal renal tubular glucose transport by stimulation of the K + channels KCNQ1 and KCNE1, which establish the electrical driving force for electrogenic glucose transport."
19764891
reach
"In conclusion, pioglitazone increases gastric acid secretion, an effect at least partially due to stimulation of SGK1 expression and SGK1 dependent upregulation of KCNQ1."
19710534
reach
"The effect of APC requires H +/K+ ATPase activity and is at least partially due to SGK1 dependent upregulation of KCNQ1."
19255508
reach
"SGK1 stimulates KCNQ1, which is required for luminal K+ recycling and thus for gastric acid secretion."
19255508
reach
"One of the genes regulated by cortisol is the serum- and glucocorticoid inducible kinase 1 (SGK1) a stimulator of the slow outward potassium channel KCNQ1 and KCNE1-one of the major mediators of cardiac repolarization."
19372749
reach
"They enhance transcription of the serum and glucocorticoid inducible kinase SGK1, which could in turn enhance gastric acid secretion by stimulating KCNQ1 K+ channels."
19710534
reach
"KCNQ1 and H +/K +-ATPase protein abundance in the parietal cell membrane was enhanced by pioglitazone treatment in sgk1 +/+ but not in sgk1-/- mice."
19710534
SGK1 activates mutated KCNQ1. 1 / 1
| 1
reach
"Whereas some mutant KCNQ1 channels had reduced basal activity but were still activated by SGK1, currents mediated by KCNQ1 (Y111C) or KCNQ1 (L114P) were paradoxically reduced by SGK1."
19008479
RPS6 affects KCNQ1
| 7 1
RPS6 binds KCNQ1.
| 7
RPS6 binds KCNQ1. 4 / 4
| 4
sparser
"Cysteine cross-linking indicates that the proximal KCNE1 COOH terminus is in interaction with the KCNQ1 S4/S5 linker and S6 gate, key structures of the gating machinery (Lvov et al., xref )."
22529812
sparser
"Structural modeling indicated that the S338F mutation specifically alters the interaction between the S6 domain of one KCNQ1 subunit and the S4-S5 linker of another, inhibiting voltage-induced movement synergistically with KCNE1 binding."
23291057
sparser
"The contrasting effects of MinK and MiRP2 on KCNQ1 activation are striking given that only subtle differences have been found in their interaction with the KCNQ1 S6 pore-lining domain ( xref , xref ; xref )."
17227916
sparser
"Previous studies have shown that the transmembrane region of KCNE1 adopts an α-helical structure [ xref ], and interacts with the KCNQ1 pore-lining S6 domain to modulate channel activity [ xref ]."
20196769
RPS6 binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"Here, we identified a protein-protein interaction between the KCNE1 C-terminal domain and the KCNQ1 S6 activation gate and S4-S5 linker."
20479109
RPS6 binds KCNE1, KCNQ1, and tmd. 1 / 1
| 1
sparser
"Several previous reports have demonstrated that the KCNE1-TMD interacts with the S6 segment or S4/S5 linker of KCNQ1."
24827085
RPS6 binds KCNE1, KCNQ1, and cooH. 1 / 1
| 1
sparser
"As mentioned previously, disulfide cross-linking establishes an interaction between the KCNE1 proximal COOH terminus (residues 70–81) and the KCNQ1 S4/S5 linker (residues 251–257) as well as the S6 gate (residues 342–370; Lvov et al., xref )."
22529812
RPS6 activates KCNQ1.
| 1
RPS6 activates KCNQ1. 1 / 1
| 1
reach
"Although mutations in the outer S6 segment were sufficient to prevent KCNQ1 inhibition by KCNE4, these structural changes did not impair biochemical interactions between the two subunits, thus illustrating that accessory subunit binding alone is not sufficient for the inhibitory effects of KCNE4."
19687231
KCN affects KCNQ1
| 1 8
KCN binds KCNQ1. 2 / 2
| 1 2
sparser
"In a heterozygote, wild type and defective monomers can co-assemble to form an impaired KCNQ1 potassium channel complex, which can result in a prolonged QT interval ( xref ; xref )."
30461122
sparser
"MinK is a potassium channel subunit which co-assembles with KvLQT1 to form the slowly activated, delayed rectifier K current that plays an important role in cardiac depolarization( xref ; xref )."
25442735
KCN binds KCNE2 and KCNQ1. 2 / 2
| 2
sparser
"Here, we show that the potassium channel subunits KCNQ1 and KCNE2 form a thyroid-stimulating hormone-stimulated, constitutively active, thyrocyte K+ channel required for normal thyroid hormone biosynthesis."
19767733
sparser
"Kcne2 colocalized and coimmunoprecipitated with Kcnq1 in mouse lungs, suggesting the formation of pulmonary Kcnq1-Kcne2 potassium channel complexes."
31162977
KCN binds KCNE1 and KCNQ1. 2 / 2
| 2
sparser
"Genetic defect is located in the KCNQ1 and KCNE1 (LQT1) genes that form the slow component of the delayed rectifier potassium channel complex (90 and 10% of cases, resp.)."
22013448
sparser
"KvLQT1 and minK associate to form the functional slowly activated delayed rectifier potassium channel ( I Ks ) [12,13] while HERG and MiRP1 associate to form the rapidly activated delayed rectifier potassium channel ( I Kr ) [10] ."
12051962
KCN binds KCNE3 and KCNQ1. 1 / 1
| 1
sparser
"The Kv7.1 protein may be also associated with MiRP2 protein to form the potassium channel ( xref )."
30420954
KCN binds KCNE1, KCNE3, and KCNQ1. 1 / 1
| 1
sparser
"The KCNQ1 gene, encodes the Kv7.1 channel protein, which can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. xref In the human heart the KCNQ1 encodes the pore-forming α subunit, and KCNE1 (also known as minK) encodes the regulatory β subunit of the KCNQ1- KCNE1 complex responsible for I Ks , the slowly activating delayed rectifier K + repolarizing current. xref Mutations in KCNQ1 are associated with hereditary LQTS1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. xref In 2002, Marx et al showed that modulation of I KS β-adrenergic receptor stimulation requires targeting of cyclic adenosine 3′,5′-monophosphate (cAMP)–dependent PKA and protein phosphatase 1 (PP1) to hKCNQ1 through the A kinase-anchoring protein (AKAP)-9, also known as yotiao. xref These authors elegantly demonstrated that yotiao binds to the human KCNQ1 by a leucine zipper motif, which is disrupted by an LQTS mutation (hKCNQ1-G589D)."
26044251
INS affects KCNQ1
| 2 6
INS inhibits KCNQ1.
| 4
INS inhibits KCNQ1. 4 / 4
| 4
reach
"Insulin substitution fully prevented the diabetes induced changes in I (Ks), KvLQT1 and MinK, however, the changes in I (to), Kv4.3, and Kv1.4 were only partially diminished by insulin."
17182020
reach
"We have previously reported that acute application of insulin suppresses the KCNQ1 and KCNE1 currents that play an important role in terminating ventricular action potential."
28882596
reach
"Acute application of insulin suppressed the KCNQ1 and KCNE1 currents and phosphorylated Akt and extracellular signal regulated kinase (ERK), the two major downstream effectors, in a concentration dependent manner."
24068254
reach
"Insulin suppresses IKs (KCNQ1 and KCNE1) currents, which require beta-subunit KCNE1."
24068254
INS binds KCNQ1.
| 2
INS binds KCNQ1. 2 / 2
| 2
sparser
"Common genetic variation in KCNQ1 is associated with insulin secretion upon oral glucose load in a German population at increased risk of type 2 diabetes."
19366866
sparser
"However, the KCNQ1 rs2237892 polymorphism was associated with levels of fasting insulin (FINS), postprandial serum insulin (PINS) and HOMA-IR and HbA1c (%); individuals with the CC genotype had noticeably lower FINS ( P  < 0.05), PINS ( P  < 0.01), and HOMA-IR ( P  < 0.05) with higher HbA1c (%) ( P  < 0.05) levels than those individuals with other genotypes ( xref )."
27857189
INS activates KCNQ1.
| 2
INS activates KCNQ1. 2 / 2
| 2
reach
"Insulin treatment augments KCNQ1 and KCNE1 currents but not KCNQ1 currents, which is associated with an increase in KCNE1 expression."
28882596
reach
"Western blotting analysis combined with these pharmacological data suggest that long-term insulin treatment augments KCNQ1 and KCNE1 currents by increasing KCNE1 protein expression."
28882596
SLC5A11 affects KCNQ1
| 2 5
SLC5A11 binds KCNQ1.
| 2 3
SLC5A11 binds KCNQ1. 4 / 4
| 1 3
sparser
"Intriguingly, we also found that KCNQ1 and SMIT2 functionally interact, and that SMIT2 inhibits KCNQ1 activity, but we do not yet know the mechanistic basis for these effects either ( xref )."
27098917
reach
"KCNQ1 also forms complexes with SMIT2, resulting in KCNQ1 inhibition and no discernible change in SMIT2 transport activity, although, again, R231A-KCNQ1 inhibits SMIT2 transport activity 55."
26123744
reach
"KCNQ1 also forms complexes with SMIT2, resulting in KCNQ1 inhibition and no discernible change in SMIT2 transport activity, although, again, R231A-KCNQ1 inhibits SMIT2 transport activity (Abbott et al., 2014)."
26123744
reach
"KCNQ1 also forms complexes with SMIT2, resulting in KCNQ1 inhibition and no discernible change in SMIT2 transport activity, although, again, R231A-KCNQ1 inhibits SMIT2 transport activity (Abbott et al., 2014)."
26123744
SLC5A1 binds SLC5A11 and KCNQ1. 1 / 1
| 1
sparser
"KCNQ1 activity was augmented by SGLT1 (a sodium-dependent glucose transporter encoded by SLC5A1 ); it should be noted that physical interactions of KCNQ1 with SGLT1 and SMIT2 have yet to be established."
27789743
SLC5A11 inhibits KCNQ1.
| 2
SLC5A11 inhibits KCNQ1. 2 / 2
| 2
reach
"Intriguingly, we also found that KCNQ1 and SMIT2 functionally interact, and that SMIT2 inhibits KCNQ1 activity, but we do not yet know the mechanistic basis for these effects either."
27098917
reach
"R231A-KCNQ1 also inhibited activity of SMIT2, a SMIT1 related myo-inositol transporter encoded by SLC5A11, while SMIT2 inhibited KCNQ1 activity, when the two were co-expressed in Xenopus oocytes [XREF_BIBR]."
28718502
MiRP1 affects KCNQ1
| 7
MiRP1 activates KCNQ1.
| 6
MiRP1 activates KCNQ1. 6 / 6
| 6
reach
"Based on our previous results that indicate the MinK COOH terminus can modulate KvLQT1 only when an interaction between KvLQT1 and the MinK transmembrane domain occurs, we conclude that MiRP1 does not modulate KvLQT1; in part because of differences in the transmembrane domain that mediate KvLQT1 association."
10962015
reach
"The recorded currents exhibit a phenotype identical to that of KvLQT1 alone (XREF_FIG C, left; XREF_TABLE), indicating that MiRP1 and Cterm-MinK either does not associate with and modulate KvLQT1 or that it is not expressed at the cell surface."
10962015
reach
"The results from this analysis indicate that MiRP1 can not modulate KvLQT1 due to differences within the transmembrane domain."
10962015
reach
"In the same study, CHO cell expression experiments showed that MinK prevented modulation of KCNQ1 by MiRP1, but that MiRPs 2-4 could override effects of MinK on KCNQ1-thus KCNQ1 may be modulated by multiple MiRPs in human heart depending on sub-tissue or even subcellular distribution and other temporal or regulatory factors."
19219384
reach
"MiRP1 does not modulate KvLQT1."
10962015
reach
"Our chimera experiments indicate that MiRP1 can not modulate KvLQT1 due to a difference in the transmembrane domain."
10962015
MiRP1 binds KCNQ1.
| 1
KCNQ1 binds MiRP1. 1 / 1
| 1
reach
"Cysteine scanning mutagenesis in MiRP1 has been applied to study interactions between MiRP1 and KCNQ1 in parietal cells and results indicated that the transmembrane domain of MiRP1 adopted an alpha-helical secondary structure with one face making intimate contact with the KCNQ1 pore domain [17]."
21087668
KCNQ1 affects RPS6
| 7
RPS6 binds KCNQ1. 4 / 4
| 4
sparser
"Cysteine cross-linking indicates that the proximal KCNE1 COOH terminus is in interaction with the KCNQ1 S4/S5 linker and S6 gate, key structures of the gating machinery (Lvov et al., xref )."
22529812
sparser
"Structural modeling indicated that the S338F mutation specifically alters the interaction between the S6 domain of one KCNQ1 subunit and the S4-S5 linker of another, inhibiting voltage-induced movement synergistically with KCNE1 binding."
23291057
sparser
"The contrasting effects of MinK and MiRP2 on KCNQ1 activation are striking given that only subtle differences have been found in their interaction with the KCNQ1 S6 pore-lining domain ( xref , xref ; xref )."
17227916
sparser
"Previous studies have shown that the transmembrane region of KCNE1 adopts an α-helical structure [ xref ], and interacts with the KCNQ1 pore-lining S6 domain to modulate channel activity [ xref ]."
20196769
RPS6 binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"Here, we identified a protein-protein interaction between the KCNE1 C-terminal domain and the KCNQ1 S6 activation gate and S4-S5 linker."
20479109
RPS6 binds KCNE1, KCNQ1, and tmd. 1 / 1
| 1
sparser
"Several previous reports have demonstrated that the KCNE1-TMD interacts with the S6 segment or S4/S5 linker of KCNQ1."
24827085
RPS6 binds KCNE1, KCNQ1, and cooH. 1 / 1
| 1
sparser
"As mentioned previously, disulfide cross-linking establishes an interaction between the KCNE1 proximal COOH terminus (residues 70–81) and the KCNQ1 S4/S5 linker (residues 251–257) as well as the S6 gate (residues 342–370; Lvov et al., xref )."
22529812
KCNQ1 affects CTNNB1
| 2 5
KCNQ1 binds CTNNB1.
| 2 3
CTNNB1 binds KCNQ1. 5 / 5
| 2 3
sparser
"Mechanistically, KCNQ1 can interact with β-catenin to affect its subcellular distribution and subsequently reduce the activity of Wnt/β-catenin signaling, which further blocks the expression of its downstream targets, including c-Myc, MMP7, and CCND1."
30144972
reach
"Bidirectional KCNQ1 : beta-catenin interaction drives colorectal cancer cell differentiation."
28373572
reach
"Mechanistically, KCNQ1 can interact with beta-catenin to affect its subcellular distribution and subsequently reduce the activity of Wnt and beta-catenin signaling, which further blocks the expression of its downstream targets, including c-Myc, MMP7, and CCND1."
30144972
sparser
"We investigated the molecular mechanisms regulating KCNQ1:β-catenin bidirectional interactions and their effects on CRC differentiation, proliferation, and invasion."
28373572
reach
"The present study explored the functional interaction of beta-catenin and KCNE1 and KCNQ1, the K+ channel complex underlying the slowly activating outwardly rectifying K+ current."
22583083
KCNQ1 inhibits CTNNB1.
| 1
KCNQ1 inhibits CTNNB1. 1 / 1
| 1
reach
"showed that KCNQ1 suppresses the Wnt and beta-catenin signaling pathway and forms complexes with beta-catenin and E-cadherin in the cell membrane."
29703730
KCNQ1 activates CTNNB1.
| 1
KCNQ1 activates CTNNB1. 1 / 1
| 1
reach
"The KCNQ1 ion channel inhibitor chromanol 293B caused membrane depolarization, redistribution of beta-catenin into the cytosol, and a reduced transepithelial electrical resistance, and stimulated CRC cell proliferation."
28373572
AMPK affects KCNQ1
| 3 1 6
AMPK activates KCNQ1.
| 3
AMPK activates KCNQ1. 3 / 3
| 3
reach
"KCNQ1 ubiqutination is promoted by AMPK activation via the ubiqutin protein ligase, Nedd4-2 in kidney cells."
24037260
reach
"Moreover, AICAR treatment of rat kidney slices ex vivo induced AMPK activation and intracellular redistribution of KCNQ1 from the basolateral membrane in collecting duct principal cells."
20861072
reach
"As a result, wild type and constitutively active AMPK significantly reduced KCNQ1 and KCNE1 mediated currents and reduced KCNQ1 abundance in the cell membrane."
21231794
AMPK phosphorylates KCNQ1.
| 1 1
AMPK phosphorylates KCNQ1. 2 / 2
| 1 1
sparser
"AMPK activation decreased KCNQ1 currents and channel surface expression in X. laevis oocytes, but AMPK did not phosphorylate KCNQ1 in vitro, suggesting an indirect regulatory mechanism."
20861072
reach
"AMPK activation decreased KCNQ1 currents and channel surface expression in X. laevis oocytes, but AMPK did not phosphorylate KCNQ1 in vitro, suggesting an indirect regulatory mechanism."
20861072
AMPK inhibits KCNQ1.
| 3 2
AMPK inhibits KCNQ1. 2 / 2
| 3 2
reach
"AMPK has previously been shown to down-regulate the epithelial Na + channel ENaC [40-43] and the K + channel KCNQ1 and KCNE1 [44], effects considered to be mediated by stimulation of the ubiquitin ligase Nedd4-2."
21501591
reach
"AMPK activation decreased KCNQ1 currents and channel surface expression in X. laevis oocytes, but AMPK did not phosphorylate KCNQ1 in vitro, suggesting an indirect regulatory mechanism."
20861072
PrKCNE1 affects KCNQ1
| 1 5
PrKCNE1 binds KCNQ1.
| 1 2
KCNQ1 binds prKCNE1. 3 / 3
| 1 2
sparser
"Our results do not exclude that prKCNE1 reaches other compartments including the plasma membrane, or that prKCNE1 and KCNQ1 may associate at the plasma membrane."
20139709
reach
"Our results do not exclude that prKCNE1 reaches other compartments including the plasma membrane, or that prKCNE1 and KCNQ1 may associate at the plasma membrane."
20139709
reach
"XREF_BIBR An alternative explanation is that only prKCNE1 that enters the early secretory pathway and associates with KCNQ1 is properly glycosylated, XREF_BIBR and this protein represents a very small fraction of the total amount injected."
20139709
PrKCNE1 activates KCNQ1.
| 2
PrKCNE1 activates KCNQ1. 2 / 2
| 2
reach
"KCNQ1 modulation by prKCNE1 requires vesicular trafficking."
20139709
reach
"These time intervals were selected because KCNQ1 modulation by prKCNE1 was evident at 6h post protein injection (XREF_FIG) and 15h should be sufficient time for prKCNE1 to diffuse to the plasma membrane (typical oocyte radius = 0.5 mm)."
20139709
PrKCNE1 inhibits KCNQ1.
| 1
PrKCNE1 inhibits KCNQ1. 1 / 1
| 1
reach
"BFA block of KCNQ1 modulation by prKCNE1 demonstrates that vesicular traffic, not direct fusion to the plasma membrane, is required for the appearance of functional prKCNE1-KCNQ1 channels."
20139709
Yotiao affects KCNQ1
| 6
KCNQ1 binds Yotiao. 5 / 5
| 5
reach
"Specifically, this mutation disrupts the binding between KCNQ1 and Yotiao, reduces PKA phosphorylation of KCNQ1, and eliminates the cAMP induced response of KCNQ1 [XREF_BIBR]."
20689672
reach
"Finally, AC9 association with the KCNQ1 and Yotiao complex sensitized PKA phosphorylation of KCNQ1 to beta-adrenergic stimulation."
22778270
reach
"These results indicate that the impaired membrane trafficking of the KCNQ1 (A590T) subunit was rescued by the co-expression with KCNQ1 (WT) subunit.The helix D region of KCNQ1 subunit contains G589, the amino acid that has been suggested to be important for interaction between KCNQ1 and Yotiao and the cAMP dependent modulation of I Ks [13]."
24713462
reach
"The disruption of the cAMP dependent I Ks regulation by mutations in helix D indicates that Yotiao interacts with KCNQ1 through this domain [13]."
24713462
reach
"The molecular nature of the binding between Yotiao and KCNQ1 involves the distal C-terminus of the channel and both the C and N termini of Yotiao."
25216213
KCNE1 binds KCNQ1 and Yotiao. 1 / 1
| 1
reach
"Using a transgenic mouse strain expressing the KCNQ1-KCNE1 subunits of I Ks, we show that AC9 is the only adenylyl cyclase (AC) isoform associated with the KCNQ1, KCNE1, and Yotiao complex in the heart."
31461851
TEA affects KCNQ1
| 2 4
TEA inhibits KCNQ1.
| 4
TEA inhibits KCNQ1. 4 / 4
| 4
reach
"While external TEA was a weak inhibitor of both KvLQT1 and wild-type I Ks channels, channels formed with F54C-MinK and G55C-MinK were over five times more sensitive to external TEA; these mutations did not alter sensitivity to internal TEA."
10968999
reach
"Currents elicited in the first 120 ms of each test pulse showed no time delay and were assumed to be non-channel-dependent; these leak currents and their variances were subtracted.In whole-cell mode, microinjection of TEA produced no inhibition of KvLQT1 channels but blocked I Ks channels readily."
10968999
reach
"On the other hand, the TEA block of KCNQ1 and KCNQ4 has a Hill slope of ~ 2 (Hadley et al., 2000), implying a different mechanism of block.The putative cognitive enhancer linopirdine and its more potent analogue 10,10-bis (4-pyridinylmethyl)-9(10H)-anthracenone (XE991) have been used as pharmacological markers of the KCNQ currents (Wang, H.-S."
11448722
reach
"Based on the ability of external TEA to block the KCNQ1 channel similar to the KCNQ1 / minK channel, Kurokawa et al. [77] concluded that minK does not line the pore of the channel."
12623297
TEA binds KCNQ1.
| 2
KCNQ1 binds TEA. 1 / 1
| 1
sparser
"Thus, it appears that the common residues in KCNQ1 coordinate high affinity TEA + binding and most likely C-type inactivation, as is the case in Shaker channels ( xref ; xref )."
11134230
KCNE1 binds KCNQ1 and TEA. 1 / 1
| 1
sparser
"Conversely, we observe none of these pore-associated attributes for Cd 2+ block of channels containing MinK-55C and a KCNQ1 mutant (K318I, V319Y) that binds TEA with high affinity."
12770875
NEDD4 affects KCNQ1
2 | 1 3
NEDD4 binds KCNQ1.
2 | 1
KCNQ1 binds NEDD4. 3 / 3
2 | 1
sparser
"However, coexpression of USP2 together with Nedd4-2 and KCNQ1 augments the binding efficiency of Nedd4-2 ( Figure 3 A), indicating that either both USP2-45 and USP-69 stabilize the binding to the KCNQ1 protein or Nedd4-2 interacts directly with USP2."
22024150
biogrid
No evidence text available
22024150
biogrid
No evidence text available
22024150
NEDD4 inhibits KCNQ1.
| 2
NEDD4 inhibits KCNQ1. 2 / 2
| 2
reach
"Here we demonstrate that KCNQ1 proteins expressed in HEK293 cells are down-regulated by Nedd4 and Nedd4 like ubiquitin protein ligases."
17289006
reach
"The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4 and Nedd4 like family."
17289006
NEDD4 activates KCNQ1.
| 1
NEDD4 activates KCNQ1. 1 / 1
| 1
reach
"4 We have previously shown that Nedd4 and Nedd4 like proteins can promote a pronounced downregulation of KCNQ1 channels, which may play a functional role in the heart."
22024150
KCNQ1 affects Yotiao
| 6
KCNQ1 binds Yotiao. 5 / 5
| 5
reach
"Specifically, this mutation disrupts the binding between KCNQ1 and Yotiao, reduces PKA phosphorylation of KCNQ1, and eliminates the cAMP induced response of KCNQ1 [XREF_BIBR]."
20689672
reach
"Finally, AC9 association with the KCNQ1 and Yotiao complex sensitized PKA phosphorylation of KCNQ1 to beta-adrenergic stimulation."
22778270
reach
"These results indicate that the impaired membrane trafficking of the KCNQ1 (A590T) subunit was rescued by the co-expression with KCNQ1 (WT) subunit.The helix D region of KCNQ1 subunit contains G589, the amino acid that has been suggested to be important for interaction between KCNQ1 and Yotiao and the cAMP dependent modulation of I Ks [13]."
24713462
reach
"The disruption of the cAMP dependent I Ks regulation by mutations in helix D indicates that Yotiao interacts with KCNQ1 through this domain [13]."
24713462
reach
"The molecular nature of the binding between Yotiao and KCNQ1 involves the distal C-terminus of the channel and both the C and N termini of Yotiao."
25216213
KCNE1 binds KCNQ1 and Yotiao. 1 / 1
| 1
reach
"Using a transgenic mouse strain expressing the KCNQ1-KCNE1 subunits of I Ks, we show that AC9 is the only adenylyl cyclase (AC) isoform associated with the KCNQ1, KCNE1, and Yotiao complex in the heart."
31461851
KCNQ1 affects USP2
2 | 2 2
USP2 binds KCNQ1. 6 / 6
2 | 2 2
sparser
"Whether or not Nedd4-2 is coexpressed does not seem to influence the binding of USP2 to KCNQ1, as both USP2-45 and USP-69 bind equally well under the 2 conditions ( Figure 3 )."
22024150
biogrid
No evidence text available
22024150
reach
"Coimmunoprecipitation assays suggested that USP2 can bind to KCNQ1 independently of the PY motif."
22024150
sparser
"Coimmunoprecipitation assays suggested that USP2 can bind to KCNQ1 independently of the PY motif."
22024150
reach
"A reduced level of ubiquitylation leads to an increased surface density of KCNQ1 channels and thereby explains the rescued current level observed in the functional experiments.Whether or not Nedd4-2 is coexpressed does not seem to influence the binding of USP2 to KCNQ1, as both USP2-45 and USP-69 bind equally well under the 2 conditions."
22024150
biogrid
No evidence text available
22024150
KCNQ1 affects SLC5A3
| 2 4
KCNQ1 activates SLC5A3.
| 3
KCNQ1 activates SLC5A3. 3 / 3
| 3
reach
"While KCNQ1 co-expression enhanced SMIT1 myo-inositol uptake, KCNQ1-KCNE2 inhibited it, as did co-expression with R231A-KCNQ1, a constitutively active mutant with the VSD locked in the active state [XREF_BIBR]."
28718502
reach
"Future investigations will be targeted at understanding exactly how KCNQ1 augments SMIT1 and NIS activity and whether there are underlying mechanistic commonalties."
27098917
reach
"KCNQ1 specific inhibitors also inhibit co-assembled SMIT1 activity; this suggests that as would be expected, K + efflux through KCNQ1 does help SMIT1 bring in more substrate, but only when the KCNQ1 conformation is amenable."
26123744
KCNQ1 binds SLC5A3.
| 2
SLC5A3 binds KCNQ1. 2 / 2
| 2
sparser
"SMIT1 also forms complexes with KCNQ1 when the two are heterologously co-expressed, and KCNE2 is not required for KCNQ1-SMIT1 complex assembly."
27789743
sparser
"Thus, SMIT1 co-expression, in the absence of extracellular myo -inositol or other SMIT1 substrates, changes ion selectivity, voltage-dependence and pharmacology of KCNQ1 in a KCNE1-dependent manner, consistent with a model in which SMIT1 physically interacts with the KCNQ1 pore or close enough to it to alter its fundamental attributes."
28718502
KCNQ1 inhibits SLC5A3.
| 1
KCNQ1 inhibits SLC5A3. 1 / 1
| 1
reach
"This suggested that it was the constitutively active nature of KCNQ1-KCNE2 channels, and not their low conductance compared to homomeric KCNQ1, that inhibited SMIT1 activity."
26123744
IsK affects KCNQ1
| 6
IsK binds KCNQ1.
| 5
KCNQ1 binds IsK. 5 / 5
| 5
reach
"KvLQT1 and IsK (minK) proteins associate to form the Iks cardiac potassium current."
9561513
reach
"In contrast, coexpression of the neuronal A kinase anchoring protein (AKAP) 79, a fragment of a cardiac AKAP (mAKAP), or cardiac AKAP15/18 restored cAMP regulation of KvLQT1 and IsK complexes inasmuch as cAMP stimulation increased the I (Ks) amplitude, increased its deactivation time constant, and negatively shifted its activation curve."
11299204
reach
"In these systems, KvLQT1 and IsK complexes were totally insensitive to cAMP regulation."
11299204
reach
"In a variety of mammalian heterologous expression systems maintained at physiological temperature, we explored cAMP regulation of recombinant KvLQT1 and IsK complexes."
11299204
reach
"At the molecular level, I (Ks) channels are composed of KvLQT1 and IsK complexes."
11299204
IsK inhibits KCNQ1.
| 1
IsK inhibits KCNQ1. 1 / 1
| 1
reach
"As visible on current traces shown in figure 3, IsK expression (5 mug/ml) markedly slowed the activation kinetics of KvLQT1 K + current."
10090886
HKCNE4 affects KCNQ1
| 5
HKCNE4 inhibits KCNQ1.
| 3
HKCNE4 inhibits KCNQ1. 3 / 3
| 3
reach
"Electrophysiological study indicated that hKCNE4 slowed the activation of KCNQ1 channel in Xenopus oocytes, whereas no effect was observed when coexpressed hKCNE4 with HERG channel in CHO cells.Recent study [20] demonstrated that KCNE4 totally inhibited the KCNQ1 current in both Xenopus oocytes and CHO cells, however, it did not alter the currents generated by KCNQ2-5 or HERG channels."
12670483
reach
"HKCNE4 slowed the KCNQ1 channel activation in oocyte cells.By bioinformatics analysis and RACE method, we cloned a novel human gene named hKCNE4 from a human cDNA library, which shared the characteristics of the KCNE family."
12670483
reach
"The preliminary eletrophysiological study indicates that hKCNE4 slows the activation of KCNQ1 channel, while the expressional difference between the KCNQ1 and the KCNE4 mRNA indicates that it is likely that KCNE4 coassembles with other KCNQ subunits as well."
12670483
HKCNE4 binds KCNQ1.
| 1
KCNQ1 binds hKCNE4. 1 / 1
| 1
reach
"In order to determine if hKCNE4 can interact with HERG and KCNQ1, similar to other KCNE subunits we coexpressed hKCNE1 with wild type (WT) KCNQ1 and with HERG in Xenopus oocytes and CHO cells.Cotransfection of hKCNE4 with WT-HERG did not modify the properties of WT-HERG channel mediated currents."
12670483
HKCNE4 activates KCNQ1.
| 1
HKCNE4 activates KCNQ1. 1 / 1
| 1
reach
"Electrophysiological study showed that hKCNE4 modulates the activation of the KCNQ1 channel."
12670483
Calcium(2+) affects KCNQ1
| 5
Calcium(2+) activates KCNQ1.
| 3
Calcium(2+) activates KCNQ1. 3 / 3
| 3
reach
"Elevations in the levels of cAMP, cyclic guanosine monophosphate (cGMP), and Ca 2+ activate apical Cl - channels (CFTR and CaCC) and basolateral K + channels (KCNQ1 and KNE3, KCNN4)."
22850599
reach
"They have been shown to activate large-conductance calcium activated potassium (BK) channels and the heteromultimeric KCNQ1 and KCNE1 (I Ks) channels."
20097192
reach
"As we will consider further, modulation of KCNE1 and KCNQ1 channel complexes by ATP and Ca ++ may constitute a protective mechanism against NIHL."
18790034
Calcium(2+) binds KCNQ1.
| 2
Calcium(2+) binds KCNQ1. 2 / 2
| 2
reach
"Ca binding to KCNQ1 associated calmodulin leads to an increase in the number of I Ks channels on the cell surface XREF_BIBR, XREF_BIBR."
28611207
reach
"One possibility is that Ca 2+ binding to KCNQ1 bound calmodulin exerts conformational effects that can be transmitted to co-assembled SMITs to Ca 2+ -dependently regulate myo-inositol intake."
28718502
TCF4 affects KCNQ1
| 5
TCF4 inhibits KCNQ1.
| 2
TCF4 inhibits KCNQ1. 2 / 2
| 2
reach
"Louis Richter, Joseph Morris, Irene Oglesby, Eimear Dunne, Dermot Kenny P4 : Beta catenin and TCF4 activation reduces KCNQ1 current in colonic monolayers Ibrahim Mohammed Mahdi Khayyat, Viviana Bustos Salgado, Brian J. Harvey P5 : Size Matters."
| PMC
reach
"P4 : Beta catenin and TCF4 activation reduces KCNQ1 current in colonic monolayers."
| PMC
TCF4 binds KCNQ1.
| 2
TCF4 binds KCNQ1. 2 / 2
| 2
reach
"To determine if TCF4 directly binds to KCNQ1 and SCN10a we first analyzed the publicly available ENCODE datasets of TCF4 ChIP-seq performed in human K562 cell line."
26971948
reach
"These results in both human and rat indicate TCF4 directly binds to genomic regions within KCNQ1 and SCN10a and suggests TCF4 could directly regulate the expression of these genes."
26971948
TCF4 decreases the amount of KCNQ1.
| 1
TCF4 decreases the amount of KCNQ1. 1 / 1
| 1
reach
"Together these results robustly validate our iTRAP method and suggest that under normal conditions, TCF4 represses the expression of KCNQ1 and SCN10a in layer 2/3 neurons of the rat prefrontal cortex."
26971948
KCNQ1 affects homeostatic process
| 5
KCNQ1 inhibits homeostatic process.
| 3
KCNQ1-A340E inhibits homeostatic process. 2 / 2
| 2
reach
"KCNQ1 A340E, with the loss-of-function phenotype, may dysregulate electrolyte homeostasis in mice independently of the activity of the renin-angiotensin-aldosterone system."
27525866
reach
"KCNQ1 A340E impairs electrolyte homeostasis independently of the renin-angiotensin-aldosterone system in mice."
27525866
KCNQ1 inhibits homeostatic process. 1 / 1
| 1
reach
"16 One might speculate that altered interactions of KCNQ1 and calmodulin, in the presence of KCNQ1 mutations, could perturb intracellular calcium homeostasis and affect the contractile performance of cardiac myocytes."
25616976
KCNQ1 activates homeostatic process.
| 2
KCNQ1 activates homeostatic process. 2 / 2
| 2
reach
"The high frequency of baseline arrhythmias and electrophysiologcal abnormalities observed in LQT and HCM hiPSC-CMs may be explained by imbalances in ion channel homeostasis caused by mutations in KCNQ1 and MYH7, respectively."
23519760
reach
"KCNQ1 co-assembles with members of the KCNE family of single transmembrane segment K + ion channel ancillary or beta subunits (XREF_FIG) to enable it to juggle such contrasting roles as cardiac myocyte repolarization, and epithelial cell ion homeostasis and transporter regulation 6."
26410412
KCNQ1 affects SLC5A11
| 2 3
SLC5A11 binds KCNQ1. 4 / 4
| 1 3
sparser
"Intriguingly, we also found that KCNQ1 and SMIT2 functionally interact, and that SMIT2 inhibits KCNQ1 activity, but we do not yet know the mechanistic basis for these effects either ( xref )."
27098917
reach
"KCNQ1 also forms complexes with SMIT2, resulting in KCNQ1 inhibition and no discernible change in SMIT2 transport activity, although, again, R231A-KCNQ1 inhibits SMIT2 transport activity 55."
26123744
reach
"KCNQ1 also forms complexes with SMIT2, resulting in KCNQ1 inhibition and no discernible change in SMIT2 transport activity, although, again, R231A-KCNQ1 inhibits SMIT2 transport activity (Abbott et al., 2014)."
26123744
reach
"KCNQ1 also forms complexes with SMIT2, resulting in KCNQ1 inhibition and no discernible change in SMIT2 transport activity, although, again, R231A-KCNQ1 inhibits SMIT2 transport activity (Abbott et al., 2014)."
26123744
SLC5A1 binds SLC5A11 and KCNQ1. 1 / 1
| 1
sparser
"KCNQ1 activity was augmented by SGLT1 (a sodium-dependent glucose transporter encoded by SLC5A1 ); it should be noted that physical interactions of KCNQ1 with SGLT1 and SMIT2 have yet to be established."
27789743
KCNQ1 affects NEDD4L
2 | 2 2 1
KCNQ1 binds NEDD4L. 5 / 5
2 | 2 2 1
reach
"The ubiquitin ligase Nedd4.2 binds KCNQ1 in response to E2 to induce channel internalization."
23529131
sparser
"The ubiquitin ligase Nedd4.2 binds KCNQ1 in response to E2 to induce channel internalization."
23529131
biogrid
No evidence text available
23529131
sparser
"Furthermore, KCNQ1/KCNE1 complexes can be internalized by Nedd4.2-dependent ubiquitinylation, through direct interaction of Nedd4.2 with KCNQ1 ( xref ); this process was recently found to be regulated by the AMP-activated protein kinase (AMPK) ( xref )."
21699843
biogrid
No evidence text available
26405101
KCNQ1 affects KCNE
| 5
KCNQ1 binds KCNE. 4 / 4
| 4
reach
"1 The channel associates with KCNE beta subunits that enforce prominent changes in the KCNQ1 (minK) current kinetics, which is likely one of the reasons for KCNQ1 and KCNE complexes being capable of participating in several different tissue functions."
22024150
reach
"While for neither protein does the N-terminus appear to be critical for dictating the channel-modulatory properties, the N-terminus is known to affect the pH sensitivity and pharmacological properties of the assembled KCNE and KCNQ1 complex."
20044833
reach
"Activation of ATP sensitive P2Y4 receptors leads to phosphorylation and de-activation of the KCNQ1 and KCNE complex, thus decreasing potassium secretion into scala media and consequently lowering the hair cell sensory transduction driving force."
20109547
reach
"The allosteric gating features, from this point of view, open what we believe to be a new perspective for reevaluation of KCNQ1 and KCNE complex regulation both in heterologous expression systems and in native tissues."
21320432
KCNQ1 binds KCNE and cysteine. 1 / 1
| 1
reach
"To determine whether these two KCNE peptides influence voltage sensing in KCNQ1 channels, we monitored the position of the S4 voltage sensor in KCNQ1 and KCNE complexes using cysteine accessibility experiments."
18079560
KCNQ1 affects IsK
| 5
KCNQ1 binds IsK. 5 / 5
| 5
reach
"KvLQT1 and IsK (minK) proteins associate to form the Iks cardiac potassium current."
9561513
reach
"In contrast, coexpression of the neuronal A kinase anchoring protein (AKAP) 79, a fragment of a cardiac AKAP (mAKAP), or cardiac AKAP15/18 restored cAMP regulation of KvLQT1 and IsK complexes inasmuch as cAMP stimulation increased the I (Ks) amplitude, increased its deactivation time constant, and negatively shifted its activation curve."
11299204
reach
"In these systems, KvLQT1 and IsK complexes were totally insensitive to cAMP regulation."
11299204
reach
"In a variety of mammalian heterologous expression systems maintained at physiological temperature, we explored cAMP regulation of recombinant KvLQT1 and IsK complexes."
11299204
reach
"At the molecular level, I (Ks) channels are composed of KvLQT1 and IsK complexes."
11299204
KCNE affects KCNQ1
| 5
KCNQ1 binds KCNE. 4 / 4
| 4
reach
"1 The channel associates with KCNE beta subunits that enforce prominent changes in the KCNQ1 (minK) current kinetics, which is likely one of the reasons for KCNQ1 and KCNE complexes being capable of participating in several different tissue functions."
22024150
reach
"While for neither protein does the N-terminus appear to be critical for dictating the channel-modulatory properties, the N-terminus is known to affect the pH sensitivity and pharmacological properties of the assembled KCNE and KCNQ1 complex."
20044833
reach
"Activation of ATP sensitive P2Y4 receptors leads to phosphorylation and de-activation of the KCNQ1 and KCNE complex, thus decreasing potassium secretion into scala media and consequently lowering the hair cell sensory transduction driving force."
20109547
reach
"The allosteric gating features, from this point of view, open what we believe to be a new perspective for reevaluation of KCNQ1 and KCNE complex regulation both in heterologous expression systems and in native tissues."
21320432
KCNQ1 binds KCNE and cysteine. 1 / 1
| 1
reach
"To determine whether these two KCNE peptides influence voltage sensing in KCNQ1 channels, we monitored the position of the S4 voltage sensor in KCNQ1 and KCNE complexes using cysteine accessibility experiments."
18079560
CAMK2_complex affects KCNQ1
| 1 3 1
CAMK2_complex phosphorylates KCNQ1.
| 1 2 1
CAMK2_complex phosphorylates KCNQ1 on S484. 3 / 3
| 2 1
reach
"In summary, in response to sustained beta-AR stimulation, CaMKII phosphorylates KCNQ1 at S484 to inhibit I Ks function."
29410121
sparser
"In summary, in response to sustained β-AR stimulation, CaMKII phosphorylates KCNQ1 at S484 to inhibit I Ks function."
29410121
sparser
"Given potential variability between experiments, controls were assessed during the time of each experimental group and the ratio of KCNQ1 to KCNE1 was standardized to produce classical characteristics of I. In summary, in response to sustained β-AR stimulation, CaMKII phosphorylates KCNQ1 at S484 to inhibit I function."
29410121
CAMK2_complex phosphorylates KCNQ1. 1 / 1
| 1
rlimsp
"Peptide fragments corresponding to KCNQ1 residues were synthesized to identify CaMKII phosphorylation at the identified sites."
29410121
CAMK2_complex binds KCNQ1.
| 1
CALM binds CAMK2_complex, KCNE1, and KCNQ1. 1 / 1
| 1
sparser
"Thus, the interaction of calmodulin and Kv7.1 appears to be critical for expression and function of I Ks , with the intriguing possibility that regulatory mechanisms could also involve some form of CaMKII interaction with calmodulin and Kv7.1 or KCNE1."
24600393
BACE1 affects KCNQ1
2 | 3
BACE1 binds KCNQ1.
2 |
KCNQ1 binds BACE1. 2 / 2
2 |
biogrid
No evidence text available
26454161
biogrid
No evidence text available
26454161
BACE1 activates KCNQ1.
| 2
BACE1 activates KCNQ1. 2 / 2
| 2
reach
"BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1 and KCNE1 (IKs)."
26454161
reach
"Finally, a recent study has reported that BACE1, which is also present in cardiac myocytes, modulates gating of the voltage dependent K + channels KCNQ1 and KCNE1 [XREF_BIBR]."
28093977
BACE1 inhibits KCNQ1.
| 1
BACE1 inhibits KCNQ1. 1 / 1
| 1
reach
"Using HEK293T cells as heterologous expression system to study the electrophysiological effects of BACE1 and KCNE1 on KCNQ1 in different combinations, our main findings were the following : (1) BACE1 slowed the inactivation of KCNQ1 current producing an increased initial response to depolarizing voltage steps."
26454161
ATP affects KCNQ1
| 2 5
ATP activates KCNQ1.
| 1 3
ATP activates KCNQ1. 3 / 3
| 1 3
reach
"Furthermore, PIP 2 sensitivity of I Ks is modulated by the KCNE1 subunit, whereas ATP activation of KCNQ1 channels is independent of simultaneous expression of KCNE1 [23]."
25892084
reach
"Here we show that intracellular ATP activates heterologously coexpressed KCNQ1 and KCNE1 as well as I (Ks) in cardiac myocytes by directly binding to the C terminus of KCNQ1 to allow the pore to open."
24190995
reach
"As we will consider further, modulation of KCNE1 and KCNQ1 channel complexes by ATP and Ca ++ may constitute a protective mechanism against NIHL."
18790034
ATP binds KCNQ1.
| 1 2
ATP binds KCNQ1. 2 / 2
| 1 2
reach
"Furthermore, the second component of IKs inhibition by Ci-VSP was reduced by AMP-PCP in the pipette filling solution, indicating that direct binding of ATP to the KCNQ1 and KCNE1 complex is required for voltage activation of IKs."
25892084
reach
"We demonstrate that intracellular ATP is a more potent modulator of I Ks activity than PIP 2, supporting the notion that direct binding of ATP to the KCNQ1 and KCNE1 channel is essential for channel activation [23]."
25892084
Sensor affects KCNQ1
| 4
Sensor activates KCNQ1. 4 / 4
| 4
reach
"KCNE3 acts by promoting voltage sensor activation in KCNQ1."
26668384
reach
"In addition, it has been shown that voltage sensor activation in KCNQ1 proceeds through an intermediate step before reaching full activation XREF_BIBR."
28383569
reach
"Together our findings suggest that altered charge-pair interactions within the voltage sensor module of KCNQ1 subunits may account for slowed I (Ks) deactivation induced by S140 or V141."
18599533
reach
"In summary, our study demonstrates that KCNE1 alters the kinetics and voltage dependence of voltage sensor activation and channel opening of KCNQ1 channels."
24769622
SLC5A3 affects KCNQ1
| 2 2
SLC5A3 binds KCNQ1.
| 2
SLC5A3 binds KCNQ1. 2 / 2
| 2
sparser
"SMIT1 also forms complexes with KCNQ1 when the two are heterologously co-expressed, and KCNE2 is not required for KCNQ1-SMIT1 complex assembly."
27789743
sparser
"Thus, SMIT1 co-expression, in the absence of extracellular myo -inositol or other SMIT1 substrates, changes ion selectivity, voltage-dependence and pharmacology of KCNQ1 in a KCNE1-dependent manner, consistent with a model in which SMIT1 physically interacts with the KCNQ1 pore or close enough to it to alter its fundamental attributes."
28718502
SLC5A3 activates KCNQ1.
| 2
SLC5A3 activates KCNQ1. 2 / 2
| 2
reach
"This was demonstrated in a recent study in which KCNQ1 is coimmunoprecipitated with SMIT1 in the epithelium of the choroid plexus and that KCNQ1 activity is modulated by SMIT1 in a heterologous expression system [XREF_BIBR]."
27397890
reach
"SMIT1 augmented the activity of both KCNQ1 channels and KCNQ1-KCNE2 channels."
27098917
NPPA affects KCNQ1
| 4
NPPA increases the amount of KCNQ1.
| 3
NPPA increases the amount of KCNQ1. 3 / 3
| 3
reach
"As shown in XREF_FIG, 10 -10 and 10 -9 M ANP significantly upregulated the expression of KCNQ1 at the mRNA level (n = 3; P < 0.05), while 10 -7 and 10 -6 M ANP significantly downregulated expression (n = 3; P < 0.05)."
24137337
reach
"The results showed that, at the protein and mRNA level, 10 -10 and 10 -9 M ANP significantly upregulated the expression of KCNQ1, while 10 -7 and 10 -6 M ANP significantly downregulated expression."
24137337
reach
"As shown in XREF_FIG, 10 -10 and 10 -9 M ANP significantly upregulated the expression of KCNQ1 at the protein level (n = 3; P < 0.05), while 10 -7 and 10 -6 M ANP significantly downregulated expression (n = 3; P < 0.05)."
24137337
NPPA decreases the amount of KCNQ1.
| 1
NPPA decreases the amount of KCNQ1. 1 / 1
| 1
reach
"The results showed that 10 -10 and 10 -9 M ANP significantly upregulated the expression of potassium voltage gated channel, KQT like subfamily, member 1 (KCNQ1) at the protein and mRNA levels, although 10 -7 and 10 -6 M ANP significantly downregulated the expression of KCNQ1."
24137337
MTX1 affects KCNQ1
| 2 2
MTX1 activates KCNQ1.
| 1 2
MTX1 activates KCNQ1. 3 / 3
| 1 2
sparser
"MTX and CPT1 activated KCNQ1 by hydrogen bonding to the foot of the voltage sensor, a previously unidentified drug site which we also find to be essential for MTX activation of the related KCNQ2/3 channel."
30443601
reach
"MTX and CPT1 activated KCNQ1 by hydrogen bonding to the foot of the voltage sensor, a previously unidentified drug site which we also find to be essential for MTX activation of the related KCNQ2/3 channel."
30443601
reach
"Two components of the M. oppositifolius leaf extract, mallotoxin (MTX) and 3-ethyl-2-hydroxy-2-cyclopenten-1-one (CPT1), augmented KCNQ1 current by negative shifting its voltage dependence of activation."
30443601
MTX1 inhibits KCNQ1.
| 1
MTX1 inhibits KCNQ1. 1 / 1
| 1
sparser
"MTX was also highly effective at augmenting currents generated by KCNQ1 in complexes with native partners KCNE1 or SMIT1; conversely, MTX inhibited KCNQ1-KCNE3 channels."
30443601
MAD2L2 affects KCNQ1
| 4
MAD2L2 binds KCNQ1.
| 3
KCNQ1 binds MAD2L2. 2 / 2
| 2
sparser
"These apparent discrepancies may have been resolved, however, with the recent discovery that KvLQT1 co-assembles with an accessory subunit, KCNE3, in colonic epithelial cells."
12191600
sparser
"Thus, these data imply that AMIT interacts with the Kv7.1 pore-forming (α) subunit instead of the accessory subunit (KCNE1)."
29621539
KCNE3 binds KCNE4, KCNQ1, and MAD2L2. 1 / 1
| 1
sparser
"The channel complexes formed by the accessory subunit KCNE3 or KCNE4 and Kv7.1 were unaffected by the Q147R mutation."
17997361
MAD2L2 inhibits KCNQ1.
| 1
MAD2L2 inhibits KCNQ1. 1 / 1
| 1
sparser
"These experiments exploited the observations that KCNQ1, but not KCNQ4, is strongly inhibited by this accessory subunit ( xref , xref ; xref )."
19687231
Kcnq1ot1 affects KCNQ1
| 4
Kcnq1ot1 inhibits KCNQ1.
| 2
Kcnq1ot1 inhibits KCNQ1. 2 / 2
| 2
reach
"Recently, it was shown that Kcnq1ot1 represses the paternal allele of Kcnq1 by interacting with the histone methyltransferases G9a and PRC2 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
20362426
reach
"Based on our previous studies, we hypothesized that paternal expression of Kcnq1ot1 represses Kcnq1 in cis, but this effect is countered when enhancer driven activity of Kcnq1 becomes established during heart development."
23028363
Kcnq1ot1 increases the amount of KCNQ1.
| 1
Kcnq1ot1 increases the amount of KCNQ1. 1 / 1
| 1
reach
"This result coincided with the up-regulated transcription of KCNQ1 in the spinal cord of human NTDs (XREF_FIG), because hypermethylated KvDMR1 is known to inhibit the expression of the lncRNA Kcnq1ot1 gene, and loss function of Kcnq1ot1 consequently promotes KCNQ1 transcription (XREF_FIG) XREF_BIBR."
25423083
Kcnq1ot1 activates KCNQ1.
| 1
Kcnq1ot1 activates KCNQ1. 1 / 1
| 1
reach
"Because correct potassium channel activity is required for normal cardiac functioning, any alteration of the Kcnq1ot1 mediated control of Kcnq1 could be responsible for abnormal heart function [XREF_BIBR]."
23835777
KL affects KCNQ1
| 2 4
KL activates KCNQ1. 4 / 4
| 2 4
reach
"KCNQ1 and KCNE1 channel activity and KCNQ1 and KCNE1 protein abundance were upregulated by coexpression of Klotho."
24457979
reach
"KCNQ1 and KCNE1 expressing oocytes were treated with human recombinant Klotho protein (30 ng/mL) for 24 h. Moreover, oocytes which express both KCNQ1 and KCNE1 and Klotho were treated with 10 muM DSA L (D-saccharic acid-1,4-lactone), a beta-glucuronidase inhibitor."
24457979
reach
"Upregulation of KCNQ1 and KCNE1 K+ channels by Klotho."
24457979
reach
"In conclusion, Klotho upregulates KCNQ1 and KCNE1 channel activity by " mainly " enhancing channel protein abundance in the plasma cell membrane, an effect at least partially mediated through the beta-glucuronidase activity of Klotho protein."
24457979
KCNQ1 affects ion channel
| 3 1
KCNQ1 binds ion channel.
| 3
KCNQ1 binds ion channel. 2 / 2
| 2
sparser
"Our findings suggest that changes in the kinetics of activation of the IKs channel may predispose to arrhythmic risk in patients who harbor KCNQ1 mutations that are associated with a relatively mild effect on ion channel current and QTc duration."
20662986
sparser
"Although KCNQ1 alone can form functional ion channels on the plasma membrane, KCNQ1 is believed to form an ion channel complex with auxiliary subunit KCNE proteins ( xref ; xref ; xref )."
22042987
KCNH2 binds KCNQ1 and ion channel. 1 / 1
| 1
sparser
"The KCNH2 and KCNQ1 mutations are associated with different ion channel dysfunctions, xref , xref and gene specific triggers of arrhythmias. xref In LQT-1, it is recognized that exercise (catecholamine) is the primary trigger because of the malfunctioning I Ks channels that leads to less effective shortening of the QT intervals during tachycardia than in normal individuals."
23094878
KCNQ1 activates ion channel.
| 1
KCNQ1 activates ion channel. 1 / 1
| 1
reach
"The high frequency of baseline arrhythmias and electrophysiologcal abnormalities observed in LQT and HCM hiPSC-CMs may be explained by imbalances in ion channel homeostasis caused by mutations in KCNQ1 and MYH7, respectively."
23519760
KCNQ1 affects TEA
| 2 2
KCNQ1 binds TEA.
| 2
KCNQ1 binds TEA. 1 / 1
| 1
sparser
"Thus, it appears that the common residues in KCNQ1 coordinate high affinity TEA + binding and most likely C-type inactivation, as is the case in Shaker channels ( xref ; xref )."
11134230
KCNE1 binds KCNQ1 and TEA. 1 / 1
| 1
sparser
"Conversely, we observe none of these pore-associated attributes for Cd 2+ block of channels containing MinK-55C and a KCNQ1 mutant (K318I, V319Y) that binds TEA with high affinity."
12770875
KCNQ1 inhibits TEA.
| 1
KCNQ1 inhibits TEA. 1 / 1
| 1
reach
"In the absence of KCNE1, wild-type (WT) KCNQ1 channels were not completely blocked by> 50 mM TEA + as previously reported (Wang et al.."
11134230
KCNQ1 activates TEA.
| 1
KCNQ1 activates TEA. 1 / 1
| 1
reach
"Two recent reports argue that MinK-55C is distant from the pore : one finds TEA does not affect Cd (2+) block if channels are formed with a KCNQ1 mutant (K318I, V319Y) that increases TEA affinity; the second proposes that Cd (2+) binds between MinK-55C and a cysteine in KCNQ1 that is posited to lie toward the channel periphery."
12770875
KCNQ1 affects RWS
| 4
KCNQ1 activates RWS.
| 3
KCNQ1 activates RWS. 2 / 2
| 2
reach
"In summary, some KCNQ1 variants can cause both JLNS (in an autosomal recessive manner) and RWS (in an autosomal dominant manner), while several KCNQ1 variants cause only JLNS in an autosomal recessive manner."
28595573
reach
"Our data show a wide KVLQT1 allelic heterogeneity among 20 families in which KVLQT1 causes RWS."
9386136
Mutated KCNQ1 activates RWS. 1 / 1
| 1
reach
"The results expand the spectrum of KCNQ1 mutations causing RWS and JLNS."
18400097
KCNQ1 inhibits RWS.
| 1
KCNQ1 inhibits RWS. 1 / 1
| 1
reach
"It is reasonable to conclude that dominant negative KCNQ1 variants can cause both RWS and JLNS."
28595573
KCNQ1 affects LQT2
| 4
KCNQ1 activates LQT2. 4 / 4
| 4
reach
"LQT1 and LQT2 are caused by gene mutations in KCNQ1 and KCNH2, respectively, and mutations in these 2 genes are responsible for about 85% of LQTS linked mutations."
21164565
reach
"LQT1, LQT2, and LQT3 are caused by mutations in KCNQ1 (LQT1), KCNH2 (LQT2), and SCN5A (LQT3), which account for approximately 90% of genotyped LQTS patients."
26282245
reach
"Among them most common are LQT1, LQT2, and LQT3, caused by mutations in KCNQ1, KCNH2, and SCN5A genes, respectively (Splawski etal."
28944242
reach
"[XREF_BIBR] A total of 16 genes associate with LQTS, and mutations in KCNQ1 or KCNH2 genes cause the most common subtypes LQT1 and LQT2, respectively."
29622001
KCNQ1 affects CDKAL1
| 4
SLC30A8 binds CDKAL1 and KCNQ1. 2 / 2
| 2
sparser
"In our present study, the findings support the individual associations of CDKN2A/2B (rs10811661), SLC30A8 (rs13266634 and rs2466293), CDKAL1 (rs7756992) and KCNQ1 (rs2237892) with not only T2DM but also IGR in a case-control study."
21103332
sparser
"We found that CDKAL1 (rs7756992), SLC30A8 (rs13266634, rs2466293), CDKN2A/2B (rs10811661) and KCNQ1 (rs2237892) were associated with T2DM with odds ratio from 1.21 to 1.35."
21103332
CDKAL1 binds KCNQ1. 1 / 1
| 1
sparser
"Four loci-1 novel with suggestive evidence (PEPD on 19q13, P = 1.4 x 10(-5)) and three previously reported-were identified; the association of CDKAL1, CDKN2A/CDKN2B, and KCNQ1 were confirmed (P < 10(-19))."
19401414
TCF7L2 binds CDKAL1, KCNQ1, and PRC1. 1 / 1
| 1
sparser
"xref shows that TCF7L2 , CDKAL1 , KCNQ1 , and PRC1 are significantly associated with IPH (OR ranged between 1.154–1.709, p value ranged between 0.00038–0.03482)."
23990951
KCNQ1 affects 3',5'-cyclic AMP
| 4
KCNQ1 inhibits 3',5'-cyclic AMP.
| 2
KCNQ1-S209F inhibits 3',5'-cyclic AMP. 1 / 1
| 1
reach
"The E160R and R237E and S209F KCNQ1 mutants, which show fixed and enhanced voltage sensor activation, respectively, largely abolish the effect of cAMP."
28687606
KCNQ1-R237E inhibits 3',5'-cyclic AMP. 1 / 1
| 1
reach
"The E160R and R237E and S209F KCNQ1 mutants, which show fixed and enhanced voltage sensor activation, respectively, largely abolish the effect of cAMP."
28687606
KCNQ1 activates 3',5'-cyclic AMP.
| 2
KCNQ1 activates 3',5'-cyclic AMP. 2 / 2
| 2
reach
"The aim of this study was to examine the effects of sevoflurane on cAMP induced chloride secretion by the mouse tracheal epithelium and the modulation of recombinant CFTR and KCNQ1 channels."
17567648
reach
"The first clue to the molecular identity of this conductance came with the observation that the cAMP sensitive K + conductance in colonic epithelial cells could be inhibited by blockers of KvLQT1 K + channels, such as chromanol 293B and azimilide (Warth et al., 1996; Suessbrich et al., 1996)."
12191600
CXXC1 affects KCNQ1
| 4
CXXC1 methylates KCNQ1. 4 / 4
| 4
sparser
"Here we report increased methylation of APBA2, APBA3, GATA4, KCNQ1, MCF2, NINJ2 and TAAR5 at gene-specific CpG sites in female BPD blood samples compared to controls."
24367640
sparser
"In skeletal muscle, CpG sites in CDKN2A , DUSP9 , HNF4A , HHEX , KCNQ1 , KLF11 , PPARGC1A and SLC30A8 were differentially methylated."
23251491
sparser
"In line with this, though at some distance from the sites described above, we observed both increased methylation of six CpG sites in KCNQ1 (4 CpGs Chr16:2464845–2465103, TSS1500, ∆beta 0.061-0.104, two CpG sites Chr: 16:2828778, ∆beta 0.08, Chr16:2858355, ∆beta 0.10) and decreased methylation of FTO (∆beta −0.113, Chr16: 54025348) before weight loss."
25651499
sparser
"A DMR was identified in one of the type-2 diabetes genes ( PROX1) and differential methylation of the six CpG sites in KCNQ1 were validated by pyrosequencing (see later)."
25651499
CDKAL1 affects KCNQ1
| 4
SLC30A8 binds CDKAL1 and KCNQ1. 2 / 2
| 2
sparser
"In our present study, the findings support the individual associations of CDKN2A/2B (rs10811661), SLC30A8 (rs13266634 and rs2466293), CDKAL1 (rs7756992) and KCNQ1 (rs2237892) with not only T2DM but also IGR in a case-control study."
21103332
sparser
"We found that CDKAL1 (rs7756992), SLC30A8 (rs13266634, rs2466293), CDKN2A/2B (rs10811661) and KCNQ1 (rs2237892) were associated with T2DM with odds ratio from 1.21 to 1.35."
21103332
CDKAL1 binds KCNQ1. 1 / 1
| 1
sparser
"Four loci-1 novel with suggestive evidence (PEPD on 19q13, P = 1.4 x 10(-5)) and three previously reported-were identified; the association of CDKAL1, CDKN2A/CDKN2B, and KCNQ1 were confirmed (P < 10(-19))."
19401414
TCF7L2 binds CDKAL1, KCNQ1, and PRC1. 1 / 1
| 1
sparser
"xref shows that TCF7L2 , CDKAL1 , KCNQ1 , and PRC1 are significantly associated with IPH (OR ranged between 1.154–1.709, p value ranged between 0.00038–0.03482)."
23990951
Yotiao affects KCNQ1
| 3
KCNQ1 binds yotiao. 2 / 2
| 2
reach
"It is the interaction between yotiao and KCNQ1 that provided the first genetic evidence supporting the importance of AKAPs in compartmentalizing PKA with its substrates."
24378903
reach
"But in this case, increasing mechanistic detail was used to represent the reversible binding of yotiao to KCNQ1 and the reversible binding of PKA and PP1 to yotiao."
21562426
KCNQ1 binds leucine and yotiao. 1 / 1
| 1
reach
"121 These authors elegantly demonstrated that yotiao binds to the human KCNQ1 by a leucine zipper motif, which is disrupted by an LQTS mutation (hKCNQ1-G589D)."
26044251
Tsh affects KCNQ1
| 3
Tsh increases the amount of KCNQ1.
| 1
Tsh increases the amount of KCNQ1. 1 / 1
| 1
reach
"We found that KCNQ1-KCNE2 channels are expressed on the basolateral side of thyroid epithelial cells, and that thyroid stimulating hormone (TSH) stimulates protein expression of KCNQ1 and KCNE2, and increases in the FRTL5 thyroid epithelial cell line a K + current with the electrophysiological and pharmacological characteristics of KCNQ1-KCNE2."
26123744
Tsh decreases the amount of KCNQ1.
| 1
Tsh decreases the amount of KCNQ1. 1 / 1
| 1
reach
"In human myocytes, TSH decreased the expression of KCND3 and KCNQ1, Ito and delayed rectifier K+ current (IKs) encoding proteins in a PKA dependent way."
31084419
Tsh activates KCNQ1.
| 1
Tsh activates KCNQ1. 1 / 1
| 1
reach
"We detected endogenously expressed KCNQ1 and KCNE2 proteins, which appeared to be upregulated by TSH or its major downstream effector, cAMP, in FRTL5 cell membrane fractions (XREF_FIG)."
19767733
Isoprenaline affects KCNQ1
| 1 2
Isoprenaline leads to the phosphorylation of KCNQ1. 2 / 2
| 1 1
reach
"We have previously shown that adenylyl cyclase Type 9 (AC9) is associated with a KCNQ1, Yotiao, and PKA complex and facilitates isoproterenol stimulated phosphorylation of KCNQ1 in an immortalized cell line."
31461851
sparser
"Deletion of AC9 resulted in the loss of isoproterenol-stimulated KCNQ1 phosphorylation in vivo, even though AC9 represents less than 3% of total cardiac AC activity."
31461851
Modified isoprenaline leads to the phosphorylation of KCNQ1. 1 / 1
| 1
reach
"Deletion of AC9 resulted in the loss of isoproterenol stimulated KCNQ1 phosphorylation in vivo, even though AC9 represents less than 3% of total cardiac AC activity."
31461851
Ion channel affects KCNQ1
| 3
KCNQ1 binds ion channel. 2 / 2
| 2
sparser
"Our findings suggest that changes in the kinetics of activation of the IKs channel may predispose to arrhythmic risk in patients who harbor KCNQ1 mutations that are associated with a relatively mild effect on ion channel current and QTc duration."
20662986
sparser
"Although KCNQ1 alone can form functional ion channels on the plasma membrane, KCNQ1 is believed to form an ion channel complex with auxiliary subunit KCNE proteins ( xref ; xref ; xref )."
22042987
KCNH2 binds KCNQ1 and ion channel. 1 / 1
| 1
sparser
"The KCNH2 and KCNQ1 mutations are associated with different ion channel dysfunctions, xref , xref and gene specific triggers of arrhythmias. xref In LQT-1, it is recognized that exercise (catecholamine) is the primary trigger because of the malfunctioning I Ks channels that leads to less effective shortening of the QT intervals during tachycardia than in normal individuals."
23094878
Ead affects KCNQ1
| 3
KCNQ1 binds ead. 2 / 2
| 2
sparser
"The present study was designed to elucidate the molecular mechanisms underlying tissue heterogeneity and EAD formation in LQT1 rabbits."
29769222
sparser
"Since I Kr activation and deactivation kinetics are similar in rabbits and humans, xref our results suggest that I Kr kinetics is likely to play an important role in LQT1 EAD formation."
29769222
KCNQ1 binds t and ead. 1 / 1
| 1
sparser
"These results strongly suggest that I to is responsible for APD gradient and RV-specific EAD formation in LQT1 rabbits."
29769222
Chromanol affects KCNQ1
| 3
Chromanol inhibits KCNQ1.
| 2
Chromanol inhibits KCNQ1. 2 / 2
| 2
sparser
"KvLQT1 K+ channels are activated via cAMP or Ca2+ and inhibited by the chromanol 293B. Interaction with as yet unknown regulatory subunits may determine the properties of KvLQT1 in the rectal gland and other epithelial tissues in which KvLQT1 is not inhibited by chromanols."
10898519
sparser
"KCNQ1 is inhibited by chromanol 293B ( xref ) and clofilium ( xref )."
21576273
Chromanol binds KCNQ1.
| 1
Chromanol binds KCNQ1. 1 / 1
| 1
sparser
"For example, NS1643 was discovered to bind to KCNQ1 and to enhance the channel conductance xref , whereas chromanol 293B could interact with KCNQ1 and inhibit the channel xref ."
26307551
Celecoxib affects KCNQ1
| 3
Celecoxib inhibits KCNQ1. 3 / 3
| 3
reach
"Inhibition of KCNQ1 and KCNQ1 and MinK by celecoxib."
22039467
reach
"Celecoxib inhibited KCNQ1 and MinK and KCNQ1 currents in concentration dependent manner (XREF_FIG)."
22039467
reach
"Celecoxib inhibited the hERG, SCN5A, KCNQ1 and KCNQ1 and MinK channels expressed in HEK-293 cells with IC 50 s of 6.0 microM, 7.5 microM, 3.5 microM and 3.7 microM respectively, and the KCND3 and KChiP2 channels expressed in CHO cells with an IC 50 of 10.6 microM."
22039467
CPKC affects KCNQ1
| 3
CPKC phosphorylates KCNQ1.
| 2
CPKC leads to the phosphorylation of KCNQ1. 2 / 2
| 2
reach
"Our results demonstrate that PKCepsilon isoenzyme mediates the inhibitory action of Ang II on I Ks and by phosphorylating distinct sites in KCNQ1 and KCNE1, cPKC and PKCepsilon isoenzymes produce the contrary regulatory effects on the channel."
29452158
reach
"By phosphorylating distinct sites in KCNQ1 and KCNE1, cPKC and PKCepsilon isoenzymes produce contrary regulatory effects on the channel."
29452158
CPKC activates KCNQ1.
| 1
CPKC activates KCNQ1. 1 / 1
| 1
reach
"Our data shows that alpha 1 -AR - cPKC signaling activates the KCNQ1 and KCNE1 channel by shifting the voltage dependence of channel activation via phosphorylation of ancillary subunit KCNE1 at Ser102."
25479336
USP2-69 affects KCNQ1
| 3
USP2-69 activates KCNQ1.
| 2
USP2-69 activates KCNQ1. 2 / 2
| 2
reach
"Expression of USP2-69 together with KCNQ1 and Nedd4-2 partially restored the membrane localization of KCNQ1."
22024150
reach
"We find by electrophysiology, biochemistry, and confocal microscopy that both USP2-45 and USP2-69 counter the Nedd4-2-dependent ubiquitylation and thereby restore the plasma membrane localization of KCNQ1 potassium channels.See Supplementary Material."
22024150
USP2-69 increases the amount of KCNQ1.
| 1
USP2-69 increases the amount of KCNQ1. 1 / 1
| 1
reach
"Both USP2-45 and USP2-69 restored the KCNQ1 protein level almost to the control level when coexpressed with Nedd4-2."
22024150
UBA2 affects KCNQ1
| 3
UBA2 binds KCNQ1. 3 / 3
| 3
sparser
"The amount of KCNQ1-R562S C-terminal fragment exhibited significantly lower binding to PIP2 (by 69.92% ± 4.14%) compared with the KCNQ1-WT C-terminal fragment ( Fig. 5 , E and F)."
30170673
sparser
"The aim of this study was the identification of the amino acids responsible for the interaction between Kv7.1 and PIP2."
24947509
sparser
"Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP2."
24681627
TCF7L2 affects KCNQ1
| 3
TCF7L2 binds KCNQ1. 1 / 1
| 1
sparser
"Of these, 8 SNPs including IGF2BP2 rs4402960, WFS1 rs734312, CDKAL1 rs7756992, SLC30A8 rs13266634, CDKN2A/B rs10811661, HHEX rs7923837, TCF7L2 rs7903146 and KCNQ1 rs2237892 were consistently and significantly associated with T2D after adjusting for sex, age and BMI (OR = 1.14–2.09, 8.5×10 −18 < P <8.5×10 −3 ) ( xref )."
24376643
TCF7L2 binds FTO, GCKR, and KCNQ1. 1 / 1
| 1
sparser
"xref shows that TCF7L2 , CDKN2BAS , KCNQ1 , FTO and GCKR are significantly associated with IFH (OR ranged between 1.171–1.524; p value ranged between 0.0023–0.0476)."
23990951
TCF7L2 binds CDKAL1, KCNQ1, and PRC1. 1 / 1
| 1
sparser
"xref shows that TCF7L2 , CDKAL1 , KCNQ1 , and PRC1 are significantly associated with IPH (OR ranged between 1.154–1.709, p value ranged between 0.00038–0.03482)."
23990951
STUB1 affects KCNQ1
| 2 1
STUB1 leads to the ubiquitination of KCNQ1. 3 / 3
| 2 1
sparser
"Engineered CHIP enhanced KCNQ1 ubiquitination, eliminated KCNQ1 surface-density, and abolished reconstituted K + currents without affecting protein expression."
29256394
sparser
"The paper not only describes the CHIP-dependent ubiquitination of KCNQ1, but also its ubiquitination by other E3 ligases such as the NEDD4-2 ligase, already shown to ubiquitinate KCNQ1."
29256394
reach
"Engineered CHIP enhanced KCNQ1 ubiquitination, eliminated KCNQ1 surface-density, and abolished reconstituted K + currents without affecting protein expression."
29256394
SP3 affects KCNQ1
| 2 1
SP3 binds KCNQ1 and SNP. 2 / 2
| 2
sparser
"Taken together with the data from the in vitro binding assay, these results suggest that Sp3 preferentially binds the non-risk allele of the endogenous KCNQ1 intronic region that contains SNP rs163184."
29207083
sparser
"Sp3 preferentially bound to the non-risk allele of the KCNQ1 SNP rs163184 region and stimulated transcriptional activity of an artificial promoter containing the SNP rs163184 region."
29207083
SP3 binds KCNQ1. 1 / 1
| 1
reach
"Taken together with the data from the in vitro binding assay, these results suggest that Sp3 preferentially binds the non risk allele of the endogenous KCNQ1 intronic region that contains SNP rs163184."
29207083
SMCHD1 affects KCNQ1
| 1 1 1
SMCHD1 binds KCNQ1.
| 1 1
KCNQ1 binds SMCHD1. 1 / 1
| 1
isi
"We showed SMCHD1 binding to an intronic region of KCNQ1 that is lost following 5-azaC treatment suggesting DNA methylation facilitated binding of SMCHD1."
31941450
SMCHD1 binds KCNQ1. 1 / 1
| 1
sparser
"We showed SMCHD1 binding to an intronic region of KCNQ1 that is lost following 5-azaC treatment suggesting DNA methylation facilitated binding of SMCHD1."
31941450
SMCHD1 decreases the amount of KCNQ1.
| 1
SMCHD1 decreases the amount of KCNQ1. 1 / 1
| 1
reach
"Indeed, deletion of SMCHD1 by CRISPR- Cas9 increases KCNQ1 gene expression confirming its role in regulating KCNQ1 gene expression."
31941450
PRKACA affects KCNQ1
1 2 |
PRKACA binds KCNQ1.
2 |
KCNQ1 binds PRKACA. 2 / 2
2 |
biogrid
No evidence text available
11799244
biogrid
No evidence text available
11799244
PRKACA phosphorylates KCNQ1.
1 |
PRKACA phosphorylates KCNQ1 on S27. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PPY affects KCNQ1
| 3
PPY inhibits KCNQ1. 3 / 3
| 3
reach
"In CHO cells an alkaline pH activated and an acidic pH inhibited 293B sensitive KCNQ1 currents."
11692278
reach
"For example, homomeric KCNQ1 is inhibited by low pH o whereas KCNQ1-KCNE2 activity is potentiated by low pH o [XREF_BIBR]."
28718502
reach
"Low external pH (pH (o)) also slowed down the activation and deactivation kinetics and strongly reduced the KCNQ1 inactivation process."
12482884
KCNQ1 affects yotiao
| 3
KCNQ1 binds yotiao. 2 / 2
| 2
reach
"It is the interaction between yotiao and KCNQ1 that provided the first genetic evidence supporting the importance of AKAPs in compartmentalizing PKA with its substrates."
24378903
reach
"But in this case, increasing mechanistic detail was used to represent the reversible binding of yotiao to KCNQ1 and the reversible binding of PKA and PP1 to yotiao."
21562426
KCNQ1 binds leucine and yotiao. 1 / 1
| 1
reach
"121 These authors elegantly demonstrated that yotiao binds to the human KCNQ1 by a leucine zipper motif, which is disrupted by an LQTS mutation (hKCNQ1-G589D)."
26044251
KCNQ1 affects thiazole
| 3
KCNQ1 activates thiazole.
| 2
KCNQ1 activates thiazole. 2 / 2
| 2
reach
"The majority of BWS cases occur sporadically, but in case of IC2 LOM caused by a germline variant in KCNQ1, the probability of transmission and the risk of offspring suffering from BWS and LQTS are increased [XREF_BIBR]."
32393365
reach
"Our study strengthens the hypothesis that proper KCNQ1 transcription is required for the establishment of IC2 methylation, but that KCNQ1 variants cause IC2 LOM only in a small number of BWS patients."
32393365
KCNQ1 inhibits thiazole.
| 1
KCNQ1 inhibits thiazole. 1 / 1
| 1
reach
"However, there are also cases where a loss of transcription of KCNQ1, either by CNVs or single nucleotide variants (SNVs), causes a LOM of the IC2 [XREF_BIBR - XREF_BIBR]."
32393365
KCNQ1 affects sensor
| 3
KCNQ1 activates sensor.
| 2
KCNQ1-S140G activates sensor. 2 / 2
| 2
reach
"We show that KCNQ1 S140G directly slows voltage sensor deactivation which in turn slows current deactivation, whereas KCNQ1 V141M has minimal effect on channel gating."
28383569
reach
"Taken together, these experiments show that KCNQ1 S140G slows voltage sensor deactivation even in the absence of channel opening."
28383569
KCNQ1 inhibits sensor.
| 1
KCNQ1-S140G inhibits sensor. 1 / 1
| 1
reach
"As KCNQ1 S140G slows voltage sensor movement and current deactivation by a similar order of magnitude, but with a slightly greater effect on the voltage sensor, we explored whether KCNQ1 S140G slows voltage sensor movement when channel pore opening is prevented."
28383569
KCNQ1 affects prKCNE1
| 1 2
KCNQ1 binds prKCNE1. 3 / 3
| 1 2
sparser
"Our results do not exclude that prKCNE1 reaches other compartments including the plasma membrane, or that prKCNE1 and KCNQ1 may associate at the plasma membrane."
20139709
reach
"Our results do not exclude that prKCNE1 reaches other compartments including the plasma membrane, or that prKCNE1 and KCNQ1 may associate at the plasma membrane."
20139709
reach
"XREF_BIBR An alternative explanation is that only prKCNE1 that enters the early secretory pathway and associates with KCNQ1 is properly glycosylated, XREF_BIBR and this protein represents a very small fraction of the total amount injected."
20139709
KCNQ1 affects pituitary hormone
| 3
KCNQ1 activates pituitary hormone.
| 2
KCNQ1 activates pituitary hormone. 1 / 1
| 1
reach
"We recently reported that two specific mutations in KCNQ1, a gene encoding the alpha subunit of a voltage gated K+ channel (Kv7.1), result in a gain-of-function in patch clamp analyses and cause pituitary hormone deficiency and maternally inherited gingival fibromatosis."
29740400
Mutated KCNQ1 activates pituitary hormone. 1 / 1
| 1
reach
"Although the exact mechanism by which the two KCNQ1 mutations cause pituitary hormone deficiency in humans is unclear, our data suggest that the KCNQ1 and KCNE2 complex may play a role in it."
29097701
KCNQ1 inhibits pituitary hormone.
| 1
KCNQ1 inhibits pituitary hormone. 1 / 1
| 1
reach
"Expression of the mutated KCNQ1 with the auxiliary potassium channel subunit KCNE2 was shown to reduce pituitary hormone secretion in functional experiments."
29703730
KCNQ1 affects localization
| 3
KCNQ1 activates localization.
| 2
KCNQ1-G569A activates localization. 1 / 1
| 1
reach
"Immunocytochemistry revealed that the KCNQ1 G569A mutation leads to impaired trafficking and localization of the mutant channels."
23015789
KCNQ1 activates localization. 1 / 1
| 1
reach
"However, I Kr was substantially reduced by KCNQ1-T587M transfection, suggesting that the effect of endogenous KCNQ1 to enhance KCNH2 membrane localization is overcome by overexpressed KCNQ1-T587M, possibly by competition for KCNH2 that is trapped with associated KCNQ1-T587M in the ER."
19959132
KCNQ1 inhibits localization.
| 1
KCNQ1 inhibits localization. 1 / 1
| 1
reach
"This is accomplished without any effect on HERG1 current.To address whether the mutations in KCNQ1 and HERG1 impede the subcellular localization of the channels, immunocytochemical analysis of transfected COS-1 cells was conducted."
16253915
KCNQ1 affects lafA
| 2 1
KCNQ1 binds lafA.
| 2
KCNQ1 binds lafA. 2 / 2
| 2
sparser
"KCNQ1 mutation is associated with LAF and rs760419 polymorphism is a susceptible marker for LAF."
23651960
sparser
"Therefore, we focused on whether the KCNQ1 gene was associated with LAF and screened for KCNQ1 mutations in a cohort of 190 unrelated individuals with LAF."
23710137
KCNQ1 activates lafA.
| 1
Mutated KCNQ1 activates lafA. 1 / 1
| 1
reach
"Second, AF is a genetically heterogeneous disorder, so a large sample is generally required to sufficiently screen for KCNQ1 mutations that cause LAF."
23710137
KCNQ1 affects exocytosis
| 3
KCNQ1 inhibits exocytosis.
| 2
KCNQ1 inhibits exocytosis. 2 / 2
| 2
reach
"siRNA knockdown of KCNQ1 in human islets enhanced depolarization induced exocytosis, whereas pharmacological inhibition in INS-1 cells did not affect basal, tolbutamide or GSIS."
25071823
reach
"siRNA silencing of KCNQ1 (64 +/- 3% [n = 3] reduction of mRNA, 74% protein reduction as measured by immunocytochemistry, and 54% reduction as measured by Western blot) likewise enhanced exocytosis from 59 +/- 9 fF/pC to 99 +/- 15 fF/pC (P = 0.011) (XREF_FIG)."
22492527
KCNQ1 activates exocytosis.
| 1
KCNQ1 activates exocytosis. 1 / 1
| 1
reach
"Inhibition of Kv7.1, as well as KCNQ1 knockdown with siRNA, increased exocytosis and insulin secretion in pancreatic beta-cells."
29259974
KCNQ1 affects ead
| 3
KCNQ1 binds ead. 2 / 2
| 2
sparser
"The present study was designed to elucidate the molecular mechanisms underlying tissue heterogeneity and EAD formation in LQT1 rabbits."
29769222
sparser
"Since I Kr activation and deactivation kinetics are similar in rabbits and humans, xref our results suggest that I Kr kinetics is likely to play an important role in LQT1 EAD formation."
29769222
KCNQ1 binds t and ead. 1 / 1
| 1
sparser
"These results strongly suggest that I to is responsible for APD gradient and RV-specific EAD formation in LQT1 rabbits."
29769222
KCNQ1 affects cell population proliferation
| 3
KCNQ1 activates cell population proliferation. 2 / 2
| 2
reach
"The KCNQ1 ion channel inhibitor chromanol 293B caused membrane depolarization, redistribution of beta-catenin into the cytosol, and a reduced transepithelial electrical resistance, and stimulated CRC cell proliferation."
28373572
reach
"In AE there is evidence that K + channels may be involved in alveolar epithelial cell repair processes [XREF_BIBR], since the inhibition of K ATP and KvLQT1 K + channels reduces wound healing, cell migration, and proliferation in a model of mechanical injury of primary cultured rat ATII cells [XREF_BIBR]."
22131798
KCNQ1 inhibits cell population proliferation. 1 / 1
| 1
reach
"In summary, our data reveal that KvLQT1 channel blockade efficiently reduces A549 and H460 cell proliferation and migration."
24366043
KCNQ1 affects calcium(2+)
| 3
KCNQ1 binds calcium(2+).
| 2
Calcium(2+) binds KCNQ1. 2 / 2
| 2
reach
"Ca binding to KCNQ1 associated calmodulin leads to an increase in the number of I Ks channels on the cell surface XREF_BIBR, XREF_BIBR."
28611207
reach
"One possibility is that Ca 2+ binding to KCNQ1 bound calmodulin exerts conformational effects that can be transmitted to co-assembled SMITs to Ca 2+ -dependently regulate myo-inositol intake."
28718502
KCNQ1 inhibits calcium(2+).
| 1
KCNQ1 inhibits calcium(2+). 1 / 1
| 1
reach
"16 One might speculate that altered interactions of KCNQ1 and calmodulin, in the presence of KCNQ1 mutations, could perturb intracellular calcium homeostasis and affect the contractile performance of cardiac myocytes."
25616976
KCNQ1 affects UBA2
| 3
UBA2 binds KCNQ1. 3 / 3
| 3
sparser
"The amount of KCNQ1-R562S C-terminal fragment exhibited significantly lower binding to PIP2 (by 69.92% ± 4.14%) compared with the KCNQ1-WT C-terminal fragment ( Fig. 5 , E and F)."
30170673
sparser
"The aim of this study was the identification of the amino acids responsible for the interaction between Kv7.1 and PIP2."
24947509
sparser
"Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP2."
24681627
KCNQ1 affects TCF7L2
| 3
TCF7L2 binds KCNQ1. 1 / 1
| 1
sparser
"Of these, 8 SNPs including IGF2BP2 rs4402960, WFS1 rs734312, CDKAL1 rs7756992, SLC30A8 rs13266634, CDKN2A/B rs10811661, HHEX rs7923837, TCF7L2 rs7903146 and KCNQ1 rs2237892 were consistently and significantly associated with T2D after adjusting for sex, age and BMI (OR = 1.14–2.09, 8.5×10 −18 < P <8.5×10 −3 ) ( xref )."
24376643
TCF7L2 binds FTO, GCKR, and KCNQ1. 1 / 1
| 1
sparser
"xref shows that TCF7L2 , CDKN2BAS , KCNQ1 , FTO and GCKR are significantly associated with IFH (OR ranged between 1.171–1.524; p value ranged between 0.0023–0.0476)."
23990951
TCF7L2 binds CDKAL1, KCNQ1, and PRC1. 1 / 1
| 1
sparser
"xref shows that TCF7L2 , CDKAL1 , KCNQ1 , and PRC1 are significantly associated with IPH (OR ranged between 1.154–1.709, p value ranged between 0.00038–0.03482)."
23990951
KCNQ1 affects TCF4
| 3
KCNQ1 binds TCF4.
| 2
TCF4 binds KCNQ1. 2 / 2
| 2
reach
"To determine if TCF4 directly binds to KCNQ1 and SCN10a we first analyzed the publicly available ENCODE datasets of TCF4 ChIP-seq performed in human K562 cell line."
26971948
reach
"These results in both human and rat indicate TCF4 directly binds to genomic regions within KCNQ1 and SCN10a and suggests TCF4 could directly regulate the expression of these genes."
26971948
KCNQ1 inhibits TCF4.
| 1
KCNQ1 inhibits TCF4. 1 / 1
| 1
reach
"Furthermore, increased expression of KCNQ1 in neurons causes decreased action potential frequency, and it is partly through this mechanism that Transcription Factor 4 (TCF4), a strong candidate gene for schizophrenia, alters the intrinsic excitability of prefrontal neurons and this excitability deficit is reversed by KCNQ1 antagonists (Rannals et al 2014)."
28188958
KCNQ1 affects SP3
| 2 1
SP3 binds KCNQ1 and SNP. 2 / 2
| 2
sparser
"Taken together with the data from the in vitro binding assay, these results suggest that Sp3 preferentially binds the non-risk allele of the endogenous KCNQ1 intronic region that contains SNP rs163184."
29207083
sparser
"Sp3 preferentially bound to the non-risk allele of the KCNQ1 SNP rs163184 region and stimulated transcriptional activity of an artificial promoter containing the SNP rs163184 region."
29207083
SP3 binds KCNQ1. 1 / 1
| 1
reach
"Taken together with the data from the in vitro binding assay, these results suggest that Sp3 preferentially binds the non risk allele of the endogenous KCNQ1 intronic region that contains SNP rs163184."
29207083
KCNQ1 affects QT syndrome type 1
| 3
KCNQ1 activates QT syndrome type 1.
| 2
KCNQ1 activates QT syndrome type 1. 2 / 2
| 2
reach
"Long QT syndrome type 1 (LQT1) is caused by mutations in KCNQ1 coding slowly activating delayed-rectifier K + channels."
31245483
reach
"Long QT syndrome type 1 (LQT1) is caused by mutations in the KCNQ1 gene resulting in a decrease in the repolarizing potassium current slow delayed rectifier current (I Ks)."
26318259
KCNQ1 inhibits QT syndrome type 1.
| 1
KCNQ1 inhibits QT syndrome type 1. 1 / 1
| 1
reach
"Long QT syndrome type 1 (LQT1) is the most common form of LQTS and is caused by loss-of-function mutations in the KCNQ1 gene encoding the I Ks channel alpha subunit 5."
25479336
KCNQ1 affects NEDD4
2 | 1
KCNQ1 binds NEDD4. 3 / 3
2 | 1
sparser
"However, coexpression of USP2 together with Nedd4-2 and KCNQ1 augments the binding efficiency of Nedd4-2 ( Figure 3 A), indicating that either both USP2-45 and USP-69 stabilize the binding to the KCNQ1 protein or Nedd4-2 interacts directly with USP2."
22024150
biogrid
No evidence text available
22024150
biogrid
No evidence text available
22024150
KCNQ1 affects MAD2L2
| 3
KCNQ1 binds MAD2L2. 2 / 2
| 2
sparser
"These apparent discrepancies may have been resolved, however, with the recent discovery that KvLQT1 co-assembles with an accessory subunit, KCNE3, in colonic epithelial cells."
12191600
sparser
"Thus, these data imply that AMIT interacts with the Kv7.1 pore-forming (α) subunit instead of the accessory subunit (KCNE1)."
29621539
KCNE3 binds KCNE4, KCNQ1, and MAD2L2. 1 / 1
| 1
sparser
"The channel complexes formed by the accessory subunit KCNE3 or KCNE4 and Kv7.1 were unaffected by the Q147R mutation."
17997361
KCNQ1 affects LQTS1
| 3
KCNQ1 activates LQTS1.
| 2
KCNQ1 activates LQTS1. 2 / 2
| 2
reach
"Several missense variants are reported to cause RWS by a dominant negative mechanism, and some KCNQ1 variants can cause both Jervell and Lange-Nielsen Syndrome (JLNS; in an autosomal recessive manner) and LQTS1 (in an autosomal dominant manner), while other KCNQ1 variants cause only JLNS."
28595573
reach
"Mutations in KCNQ1 and HERG cause the congenital LQTS1 XREF_BIBR and LQTS2, XREF_BIBR respectively."
20348026
KCNQ1 inhibits LQTS1.
| 1
KCNQ1 inhibits LQTS1. 1 / 1
| 1
reach
"LQTS1 can be caused by loss-of-function variants in the KCNQ1 encoded cardiac potassium channel [XREF_BIBR]."
28595573
KCNQ1 affects Kcnq1ot1
| 3
KCNQ1 increases the amount of Kcnq1ot1. 3 / 3
| 3
reach
"This result coincided with the up-regulated transcription of KCNQ1 in the spinal cord of human NTDs (XREF_FIG), because hypermethylated KvDMR1 is known to inhibit the expression of the lncRNA Kcnq1ot1 gene, and loss function of Kcnq1ot1 consequently promotes KCNQ1 transcription (XREF_FIG) XREF_BIBR."
25423083
reach
"However, Kcnq1ot1 regulates Kcnq1 transcription, not by regulating its imprinting, but through modulating chromatin flexibility and access to enhancers [XREF_BIBR]."
24113581
reach
"Kcnq1ot1, a new lncRNA regulates Kcnq1 transcription through modulating chromatin flexibility and access of transcriptional machinery to its enhancer [XREF_BIBR]."
27848894
KCNQ1 affects KCNE5
| 2 3
KCNE5 binds KCNQ1. 1 / 1
| 2 1
sparser
"From biochemical studies, KCNE2 to KCNE5 each can bind KCNQ1 and alter its channel properties ( xref ; xref )."
30461122
KCNE5 binds KCNE4 and KCNQ1. 1 / 1
| 1
sparser
"We have reported interaction of KCNE4 and KCNE5 with KCNQ1, providing modulations of the KCNQ1 current ( Grunnet et al., 2002a ; Angelo et al., 2002 )."
12944270
KCNE1 binds KCNE5, KCNE3, and KCNQ1. 1 / 1
| 1
sparser
"We determined inactivation properties and compared K+ vs. Rb+ inward currents for channels formed by co-assembly of KCNQ1 with KCNE1, KCNE3 and KCNE5, and for homomeric KCNQ1 channels with point mutations in the pore helix S5 or S6 transmembrane domains."
14561821
KCNQ1 affects IGF2BP2
| 3
IGF2BP2 binds KCNQ1. 3 / 3
| 3
sparser
"Similarly, the nominal association of variants IGF2BP2 rs4402960 and KCNQ1 rs2237892 nominally associated with TRG/HDL-C ( p  = 0.003) and DBP ( p  = 0.004) respectively agree with this principle and therefore have a high probability to be replicated."
29800730
sparser
"Association with T2D of variants IGF2BP2 rs4402960 and KCNQ1 rs2237892 in a Mexican population was found with a p  = 0.001 and p  < 0.050 respectively under the additive model ( Gamboa-Meléndez et al., 2012 )."
29800730
sparser
"That suggested a potential gene-gene interaction of gene IGF2BP2 with KCNQ1 on overweight in our study."
24959828
KCNQ1 affects IGF2
| 2 1
KCNQ1 binds IGF2.
| 2
IGF2 binds KCNQ1. 2 / 2
| 2
sparser
"These functional associations of IGF2 and KCNQ1 rely on publications reporting how a differentially methylated region in KCNQ1 controls imprinted expression of other genes in the neighborhood xref and about epigenetic abnormalities in the IGF2/H19 region of Beckwith-Wiedemann syndrome patients xref ."
23226257
sparser
"Our results suggest that the aberrant methylation of IGF2 and KCNQ1 genes may be associated with sperm DNA damage."
30680773
KCNQ1 decreases the amount of IGF2.
| 1
KCNQ1 decreases the amount of IGF2. 1 / 1
| 1
reach
"For example, the KCNQ1 gene locus has been shown to influence expression of insulin like growth factor 2 (IGF2), thus, dysregulation of IGF2 expression by KCNQ 1 polymorphisms may lead to aberrant islet cell development and function [XREF_BIBR - XREF_BIBR]."
22134088
KCNQ1 affects IC2
| 2 1
KCNQ1 binds IC2.
| 2
KCNQ1 binds IC2. 1 / 1
| 1
sparser
"These data demonstrate that a deletion removing both main promoters and affecting the expression of KCNQ1 is associated with absence of IC2 methylation on the maternal chromosome."
30635621
KCNQ1 binds KCNQ1OT1 and IC2. 1 / 1
| 1
sparser
"In the mouse, targeted deletion of the orthologous IC2 region results in growth restriction and loss of imprinting of six genes including Cdkn1c and Phlda2 when paternally inherited. xref By contrast, paternal transmission of 250–330 kb deletions, including most of the KCNQ1 gene, IC2 and KCNQ1OT1 is associated with normal phenotype in humans (refs. xref and xref ; also see xref )."
23243085
KCNQ1 inhibits IC2.
| 1
KCNQ1 inhibits IC2. 1 / 1
| 1
reach
"However, there are also cases where a loss of transcription of KCNQ1, either by CNVs or single nucleotide variants (SNVs), causes a LOM of the IC2 [XREF_BIBR - XREF_BIBR]."
32393365
KCNQ1 affects GH1
| 3
KCNQ1 activates GH1. 3 / 3
| 3
reach
"Recently, we showed that two missense mutations in KCNQ1 (potassium voltage gated channel subfamily Q member 1), underlie maternally inherited gingival fibromatosis and autosomal dominant growth hormone deficiency which, in some patients, expanded to multiple pituitary hormone deficiency."
29703730
reach
"Recently, mutations in KCNQ1, a potassium channel gene usually linked to long QT syndrome, were reported to cause maternally inherited gingival fibromatosis and growth hormone deficiency (GHD)."
29703730
reach
"The current work was sparked by our recent finding which showed that two specific mutations in KCNQ1, p. (Arg116Leu) and p. (Pro369Leu), underlie growth hormone deficiency and maternally inherited gingival fibromatosis."
29740400
KCNQ1 affects ADCY9
| 1 2 1
ADCY9 binds AKAP9 and KCNQ1. 2 / 2
| 2
sparser
"Importantly, formation of a KCNQ1–yotiao–AC9 complex sensitized KCNQ1 to β-adrenergic receptor stimulation, allowing the channel to respond to significantly lower concentrations of agonist ( xref )."
24378903
sparser
"The interaction of AC9 with Yotiao and KCNQ1 was shown by immunoprecipitation of the complex from cells co-expressing all three proteins, a transgenic mouse line with cardiac expression of KCNQ1–KCNE1, and from guinea pig hearts, which endogenously express the complex."
29367580
ADCY9 binds KCNQ1. 1 / 1
| 1 1
reach
"We now show that either AC2 or AC9 can associate with KCNQ1 in a complex mediated by Yotiao."
22778270
JLN affects KCNQ1
| 3
JLN activates KCNQ1. 3 / 3
| 3
reach
"Here we demonstrate that JLN, but not RW, mutations suppress dominant negative effects of the truncated KvLQT1, thereby explaining the different phenotypes found in RW and JLN mutation heterozygous carriers."
10090886
reach
"In a mammalian expression system, we found that JLN, but not RW, mutations suppress the dominant negative effects of the truncated KvLQT1."
10090886
reach
"Here, we also show that JLN, but not RW, mutations suppress the dominant negative properties of KvLQT1 isoform 2."
10090886
IGF2BP2 affects KCNQ1
| 3
IGF2BP2 binds KCNQ1. 3 / 3
| 3
sparser
"Similarly, the nominal association of variants IGF2BP2 rs4402960 and KCNQ1 rs2237892 nominally associated with TRG/HDL-C ( p  = 0.003) and DBP ( p  = 0.004) respectively agree with this principle and therefore have a high probability to be replicated."
29800730
sparser
"Association with T2D of variants IGF2BP2 rs4402960 and KCNQ1 rs2237892 in a Mexican population was found with a p  = 0.001 and p  < 0.050 respectively under the additive model ( Gamboa-Meléndez et al., 2012 )."
29800730
sparser
"That suggested a potential gene-gene interaction of gene IGF2BP2 with KCNQ1 on overweight in our study."
24959828
IC2 affects KCNQ1
| 3
IC2 binds KCNQ1.
| 2
KCNQ1 binds IC2. 1 / 1
| 1
sparser
"These data demonstrate that a deletion removing both main promoters and affecting the expression of KCNQ1 is associated with absence of IC2 methylation on the maternal chromosome."
30635621
KCNQ1 binds KCNQ1OT1 and IC2. 1 / 1
| 1
sparser
"In the mouse, targeted deletion of the orthologous IC2 region results in growth restriction and loss of imprinting of six genes including Cdkn1c and Phlda2 when paternally inherited. xref By contrast, paternal transmission of 250–330 kb deletions, including most of the KCNQ1 gene, IC2 and KCNQ1OT1 is associated with normal phenotype in humans (refs. xref and xref ; also see xref )."
23243085
IC2 methylates KCNQ1.
| 1
IC2 methylates KCNQ1. 1 / 1
| 1
sparser
"The majority of BWS cases occur sporadically, but in case of IC2 LOM caused by a germline variant in KCNQ1 , the probability of transmission and the risk of offspring suffering from BWS and LQTS are increased [ xref ]."
32393365
FSD1 affects KCNQ1
| 3
FSD1 inhibits KCNQ1.
| 2
FSD1 inhibits KCNQ1. 2 / 2
| 2
reach
"Moreover, the expression levels of mir-1, that has been proved to suppress KCNQ1 and KCNE1 because up-regulated by hyperglycemia [XREF_BIBR], was also evaluated."
29707106
reach
"Also, the expression levels of miR-1 proved to suppress KCNQ1 and KCNE1, were analyzed."
29707106
FSD1 activates KCNQ1.
| 1
FSD1 activates KCNQ1. 1 / 1
| 1
reach
"MiR-1 and miR-133 have been shown experimentally to target KCNE1 and KCNQ1, which are the genes that comprise the channels that regulates the slow delayed rectifier current (I Ks)."
18988904
FOXH1 affects KCNQ1
| 3
FOXH1 activates KCNQ1.
| 2
FOXH1 activates KCNQ1. 2 / 2
| 2
sparser
"The trajectories maintained tight coupling between VSLs and pore, a property that underlies KCNQ1 fast activation without substantial delay."
30292722
sparser
"When test pulses to voltages between − 40 mV and + 40 mV were applied, KCNQ1 currents showed fast activation during the first ~ 500 ms of the voltage step, followed by a second, slower activation time course."
19540844
FOXH1 inhibits KCNQ1.
| 1
FOXH1 inhibits KCNQ1. 1 / 1
| 1
sparser
"Without sufficient other information concerning the inactivation dynamics of I KCNQ5 , we have, therefore, used the fast inactivation of I KCNQ1 and the slow inactivation of I KCNQ4 to represent the fast and slow inactivation conditions for I KCNQ5 , i.e. , w Q5∞  =  w Q1∞ , τw Q5  =  τw Q1 , s Q5∞  =  s Q4∞ andτ s Q5  = τ s Q4 ."
25474527
CPT1A affects KCNQ1
| 1 2
CPT1A activates KCNQ1. 3 / 3
| 1 2
reach
"Two components of the M. oppositifolius leaf extract, mallotoxin (MTX) and 3-ethyl-2-hydroxy-2-cyclopenten-1-one (CPT1), augmented KCNQ1 current by negative shifting its voltage dependence of activation."
30443601
sparser
"MTX and CPT1 activated KCNQ1 by hydrogen bonding to the foot of the voltage sensor, a previously unidentified drug site which we also find to be essential for MTX activation of the related KCNQ2/3 channel."
30443601
reach
"MTX and CPT1 activated KCNQ1 by hydrogen bonding to the foot of the voltage sensor, a previously unidentified drug site which we also find to be essential for MTX activation of the related KCNQ2/3 channel."
30443601
CPOX affects KCNQ1
| 3
CPOX activates KCNQ1.
| 2
CPOX activates KCNQ1. 2 / 2
| 2
reach
"Differently, HCP significantly increases the overall conductance of the homomeric KCNQ1 (XREF_FIG)."
23251633
reach
"Hence, HCP increases overall conductance of the KCNQ1 by left shifting the G-V curve but not affecting inactivation."
23251633
CPOX increases the amount of KCNQ1.
| 1
CPOX increases the amount of KCNQ1. 1 / 1
| 1
reach
"HCP potently increases the current amplitude of KCNQ1 and KCNE1 expressed by stabilizing the channel in an open state with an EC 50 of 4.61 +/-1.29 muM."
23251633
Arg-Trp affects KCNQ1
| 3
Arg-Trp activates KCNQ1. 3 / 3
| 3
reach
"In a mammalian expression system, we found that JLN, but not RW, mutations suppress the dominant negative effects of the truncated KvLQT1."
10090886
reach
"Here we demonstrate that JLN, but not RW, mutations suppress dominant negative effects of the truncated KvLQT1, thereby explaining the different phenotypes found in RW and JLN mutation heterozygous carriers."
10090886
reach
"Here, we also show that JLN, but not RW, mutations suppress the dominant negative properties of KvLQT1 isoform 2."
10090886
AR affects KCNQ1
| 3
AR activates KCNQ1. 3 / 3
| 3
reach
"Our results suggest that alpha 1 AR mediated direct internalization of KCNQ1 is AP2 and clathrin dependent and may be triggered by ubiquitination of KCNQ1 via the AMP dependent kinase (AMPK)/Nedd4-2 pathway."
31491415
reach
"Because we have observed down-regulation of KCNQ1 and KCNE1 currents by activation of the alpha 1 -adrenergic receptor (alpha 1 AR) that activates PKC, this study investigated whether alpha 1 AR causes internalization of the KCNQ1 protein."
31491415
reach
"Activation of alpha 1A AR and alpha 1B AR caused marked internalization of KCNQ1, which was not KCNE1 dependent."
31491415
ADCY9 affects KCNQ1
| 1 2 1
ADCY9 binds AKAP9 and KCNQ1. 2 / 2
| 2
sparser
"Importantly, formation of a KCNQ1–yotiao–AC9 complex sensitized KCNQ1 to β-adrenergic receptor stimulation, allowing the channel to respond to significantly lower concentrations of agonist ( xref )."
24378903
sparser
"The interaction of AC9 with Yotiao and KCNQ1 was shown by immunoprecipitation of the complex from cells co-expressing all three proteins, a transgenic mouse line with cardiac expression of KCNQ1–KCNE1, and from guinea pig hearts, which endogenously express the complex."
29367580
ADCY9 binds KCNQ1. 1 / 1
| 1 1
reach
"We now show that either AC2 or AC9 can associate with KCNQ1 in a complex mediated by Yotiao."
22778270
(20S)-ginsenoside Rg3 affects KCNQ1
| 3
(20S)-ginsenoside Rg3 activates KCNQ1. 3 / 3
| 3
reach
"We have previously reported that ginsenoside Rg3 activated human KCNQ1 K + channel currents through interactions with the K318 and V319 residues XREF_BIBR."
24198658
reach
"Ginsenoside Rg3 activates human KCNQ1 K+ channel currents through interacting with the K318 and V319 residues : a role of KCNE1 subunit."
20399767
reach
"In a previous study, we showed that ginsenoside Rg3 activates human KCNQ1 K + channel currents through interactions with the K318 and V319 residues."
24198658
Voltage-gated potassium channel affects KCNQ1
| 2
KCNQ1 binds voltage-gated potassium channel. 1 / 1
| 1
sparser
"For example, in male pups the expression of the gene Kcnq1 , a voltage-gated potassium channel, which has been associated with Jervell and Lange-Nielsen syndrome and hereditary long QT syndrome 1 [ xref , xref ], and the gene Tsix that expresses the non-coding antisense transcript required for imprinted X inactivation [ xref ], were down-regulated."
25629700
KCNH2 binds KCNQ1 and voltage-gated potassium channel. 1 / 1
| 1
sparser
"Both LQT1 and LQT2 are associated with loss of function of voltage-gated potassium channels (I Ks and I Kr ). xref "
20728018
Tr-rKCNQ1 product affects KCNQ1
| 2
Tr-rKCNQ1 product decreases the amount of KCNQ1. 2 / 2
| 2
reach
"As I Ks in the heart was composed of KCNQ1 and minK, it was investigated whether the tr-rKCNQ1 product suppressed the potassium current when KCNQ1 and minK were co-expressed."
12051693
reach
"As I Ks in the heart was composed of KCNQ1 and minK, it was investigated whether the tr-rKCNQ1 product suppressed the potassium current when KCNQ1 and minK were co-expressed."
12051693
Tacrolimus hydrate affects KCNQ1
| 2
Tacrolimus hydrate activates KCNQ1. 2 / 2
| 2
reach
"The results of this study suggest lack of association between KCNJ11 and KCNQ1 gene polymorphisms and post-transplant diabetes mellitus in kidney allograft recipients treated with tacrolimus in the Polish population."
28805561
reach
"The aim of this study was to examine the association between KCNJ11 and KCNQ1 gene polymorphisms and posttransplant diabetes mellitus in kidney allograft recipients treated with tacrolimus."
28805561
Puerarin affects KCNQ1
| 2
Puerarin inhibits KCNQ1. 2 / 2
| 2
reach
"In this study, our results partly revealed that puerarin probably inhibit KCNQ1 and IKs via direct inhibition, as puerarin was applied directly to the intracellular side and reduced the open probability of the channels under the inside-out recording model."
27762288
reach
"At a micromolar concentration, puerarin inhibited KvLQT1 and IKs and when application of milimolar puerarin, it affected Kir2.1, Kir2.3, KvLQT1 and IKs."
27762288
Pioglitazone affects KCNQ1
| 2
Pioglitazone activates KCNQ1. 2 / 2
| 2
reach
"KCNQ1 and H +/K +-ATPase protein abundance in the parietal cell membrane was enhanced by pioglitazone treatment in sgk1 +/+ but not in sgk1-/- mice."
19710534
reach
"In conclusion, pioglitazone increases gastric acid secretion, an effect at least partially due to stimulation of SGK1 expression and SGK1 dependent upregulation of KCNQ1."
19710534
MiR-133 affects KCNQ1
| 2
MiR-133 activates KCNQ1. 2 / 2
| 2
reach
"KCNQ1 and KCNH2 mRNA and protein are directly negatively modulated by miR-133, which can target the 3 ' UTR of KCNQ1 and KCNH2 mRNA [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
29843720
reach
"miR-1 and miR-133 have been shown experimentally to target KCNE1 and KCNQ1, which are the genes that comprise the channels that regulates the slow delayed rectifier current (I Ks)."
18988904
LafA affects KCNQ1
| 2
KCNQ1 binds lafA. 2 / 2
| 2
sparser
"KCNQ1 mutation is associated with LAF and rs760419 polymorphism is a susceptible marker for LAF."
23651960
sparser
"Therefore, we focused on whether the KCNQ1 gene was associated with LAF and screened for KCNQ1 mutations in a cohort of 190 unrelated individuals with LAF."
23710137
Isoflurane affects KCNQ1
| 2
Isoflurane inhibits KCNQ1.
| 1
Isoflurane inhibits KCNQ1. 1 / 1
| 1
reach
"Under heterozygous conditions, isoflurane inhibited A341V + KCNQ1 + KCNE1 by 65.2 +/- 3.0% (n = 13) and wild-type KCNQ1 + KCNE1 (2:1 ratio) by 32.0 +/- 4.5% (n = 11)."
25585005
Isoflurane activates KCNQ1.
| 1
Isoflurane activates KCNQ1. 1 / 1
| 1
reach
"The hypothesis that volatile anesthetics act on channel protein is, however, not yet confirmed.In conclusion, the volatile anesthetics isoflurane and sevoflurane cause potency dependent reductions in I Ks and KvLQT1 currents, and this result is consistent with the clinical observations that volatile anesthetics prolong the ventricular repolarization (Q-T interval)."
12616988
Glucose affects KCNQ1
| 2
Glucose inhibits KCNQ1.
| 1
Glucose inhibits KCNQ1. 1 / 1
| 1
reach
"Volker Vallon found that glucose induced currents of small intestinal mucosa are reduced in KCNQ1 -/- mice compared to wild-type mice [XREF_BIBR], indicating an important role of KCNQ1 in regulating intestinal nutrient absorption."
26784222
Glucose decreases the amount of KCNQ1.
| 1
Glucose decreases the amount of KCNQ1. 1 / 1
| 1
reach
"BF-5m dose-dependently increased plasmatic KCNE1 and KCNQ1 levels, significantly reduced by high glucose medium, paralleled by a significant down-regulation of miR-1 levels."
29707106
Forskolin affects KCNQ1
| 2
Forskolin activates KCNQ1. 2 / 2
| 2
reach
"Treatment with GSK-3 iX decreased the forskolin stimulated KCNQ1 currents."
| PMC
reach
"Results : Forskolin stimulated KCNQ1 currents were measured in untreated cl.19 A monolayers."
| PMC
Fenofibrate affects KCNQ1
| 1 2
Fenofibrate inhibits KCNQ1.
| 1 1
Fenofibrate inhibits KCNQ1. 1 / 1
| 1 1
reach
"Membrane permeabilization experiments on T84 cells indicated that fenofibrate inhibits basolateral cAMP stimulated K (+) channels (putatively KCNQ1 and KCNE3) without affecting Ca (2+)-stimulated K (+) channel activity, whereas clofibrate inhibits both K (+) pathways."
17916649
Fenofibrate activates KCNQ1.
| 1
Fenofibrate activates KCNQ1. 1 / 1
| 1
reach
"Fenofibrate inhibits intestinal Cl- secretion by blocking basolateral KCNQ1 K+ channels."
17916649
Ezogabine affects KCNQ1
| 2
Ezogabine activates KCNQ1. 2 / 2
| 2
reach
"The M-type current was activated by 1) 10 muM retigabine, an opener of all KCNQ channels except KCNQ1, 2) 10 muM zinc pyrithione, which augments all KCNQ channels except KCNQ3, and 3) 50 muM N-ethylmaleimide, which activates KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3, channels."
22135213
reach
"In contrast, retigabine did not enhance cardiac KCNQ1 currents."
11466425
Estrogen affects KCNQ1
| 2
Estrogen inhibits KCNQ1. 2 / 2
| 2
reach
"Therefore, in distal colonic cells estrogen inhibition of KCNQ1 activity leads to the inhibition of transepithelial chloride secretion."
24223826
reach
"We have previously shown that estrogen causes a female-gender specific inhibition of KCNQ1 channels in rat colonic crypts, producing an antisecretory response which is also dependent on PKA activation and association with the KCNQ1 channel."
21747769
CtcA affects KCNQ1
| 2
CtcA binds KCNQ1.
| 1
KCNQ1 binds ctcA. 1 / 1
| 1
reach
"To find a possible physiological function of the constitutively open KCNQ1 and CHIF complex, the precise localization of KCNQ1 and CHIF in distal colon and kidney from control and salt depleted rats was determined by confocal microscopy."
16476578
CtcA activates KCNQ1.
| 1
CtcA activates KCNQ1. 1 / 1
| 1
reach
"In both expression systems, we find that CHIF drastically modulates the KCNQ1 current; in the presence of CHIF, the KCNQ1 channels open at all membrane potentials."
16476578
CAMP-dependent affects KCNQ1
| 2
CAMP-dependent phosphorylates KCNQ1. 2 / 2
| 2
sparser
"Few pathogenic variants have been reported in this gene, the AP duration is prolonged due to a reduction of the cAMP-dependent phosphorylation of Kv7.1, and reduction in cAMP stimulation response occurs. xref "
26566530
sparser
"Loss of this scaffold decreases cAMP-dependent PKA phosphorylation of KCNQ1, eliminates the functional response by I Ks , and prolongs the action potential [ xref ]."
29367580
Berberine affects KCNQ1
| 2
Berberine inhibits KCNQ1. 2 / 2
| 2
reach
"Similarly, berberine inhibited a cAMP stimulated and chromanol 293B sensitive whole-cell conductance, suggesting berberine inhibits KCNQ1 channels."
21747769
reach
"In HEK-293 cells, the IC50 for berberine was 3.1 +/- 0.5 microM on hERG compared with 11 +/- 4% decreases on KCNQ1 and KCNE1 channels by 100 microM berberine."
16424781
VSD affects KCNQ1
| 2
VSD activates KCNQ1. 2 / 2
| 2
reach
"Modification of I230C is voltage dependent in the presence of endogenous PIP 2 and after PIP 2 depletion by CiVSP, confirming that PIP 2 is not required for VSD activation in KCNQ1."
24904429
reach
"To test if PIP 2 affects VSD activation in KCNQ1 channels, VSD activation was detected by using voltage clamp fluorometry (VCF) while dynamically depleting the endogenous PIP 2 by expressing and activating the lipid-phosphatase CiVSP."
24904429
V72T-KCNE3 affects KCNQ1
| 2
V72T-KCNE3 inhibits KCNQ1. 2 / 2
| 2
reach
"Thus, V72T-KCNE3 slows KCNQ1 activation almost as much as KCNE1 does, and eliminates KCNQ1-KCNE3 constitutive activation 33."
26410412
reach
"Thus, V72T-KCNE3 slows KCNQ1 activation almost as much as KCNE1 does, and eliminates KCNQ1-KCNE3 constitutive activation (Melman et al., 2002)."
26410412
USP2-45 affects KCNQ1
| 2
USP2-45 increases the amount of KCNQ1.
| 1
USP2-45 increases the amount of KCNQ1. 1 / 1
| 1
reach
"Both USP2-45 and USP2-69 restored the KCNQ1 protein level almost to the control level when coexpressed with Nedd4-2."
22024150
USP2-45 activates KCNQ1.
| 1
USP2-45 activates KCNQ1. 1 / 1
| 1
reach
"We find by electrophysiology, biochemistry, and confocal microscopy that both USP2-45 and USP2-69 counter the Nedd4-2-dependent ubiquitylation and thereby restore the plasma membrane localization of KCNQ1 potassium channels.See Supplementary Material."
22024150
TYMS affects KCNQ1
| 2
TYMS binds KCNQ1. 1 / 1
| 1
sparser
"Since there are no cysteine residues in the extracellular domain of KCNE1, it has been proposed that TMS interacts with its partner protein KCNQ1."
11944086
TYMS binds IK and KCNQ1. 1 / 1
| 1
sparser
"The aim of this study was therefore to investigate the interaction of TMS with KCNQ1 and the respective K+current IK."
11944086
TRAF6 affects KCNQ1
1 1 |
TRAF6 binds KCNQ1. 2 / 2
1 1 |
biogrid
No evidence text available
14743216
hprd
No evidence text available
14743216
TG affects KCNQ1
| 1 1
TG inhibits KCNQ1.
| 1
TG inhibits KCNQ1. 1 / 1
| 1
reach
"We have evaluated a transgenic (TG) mouse (FVB) overexpressing a dominant negative KvLQT1 isoform, as an in vivo screening model for I (Kr) blocking drugs."
11334836
TG binds KCNQ1.
| 1
KCNQ1 binds MT and TG. 1 / 1
| 1
sparser
"According to the results, the block of KCNQ1-related currents by HMR1556 contributed to complete functional restoration of the conduction system in the TG MT mice; however, HMR1556 had no effect on the ECG in either TG WT mice or wild-type mice, indicating that it was the S140G mutation rather than overexpression of KCNQ1 that was associated with AVBs in the TG MT mice."
17467630
StKTx23 toxin affects KCNQ1
| 2
StKTx23 toxin inhibits KCNQ1. 2 / 2
| 2
reach
"StKTx23 toxin, with a cystine stabilized alpha-helix-loop-beta-sheet (CS-alpha and beta) fold motif, could inhibit Kv1.3 channel, but not the KCNQ1 channel."
22511981
reach
"StKTx23 toxin, with a CS-alpha and beta fold motif, inhibits Kv1.3 channels, but not the KCNQ1 channel."
22511981
SSD609 affects KCNQ1
| 2
SSD609 inhibits KCNQ1. 2 / 2
| 2
reach
"As shown in XREF_FIG, SSD609 reversibly inhibited the channel conductance of I ks (KCNQ1 and KCNE1), specifically affecting the KCNE1 auxiliary subunit, because no inhibition of the KCNQ1 channel expressed in CHO cells was observed."
26307551
reach
"Although SSD609 inhibited KCNQ1 and KCNE3, the distribution of the KCNQ1 and KCNE3 complex in the colon and other non cardiac cells XREF_BIBR precluded any inhibitory effect of SSD609 on KCNQ1 and KCNE3 in the cardiovascular system."
26307551
S4S5(L) peptides affects KCNQ1
| 2
S4S5(L) peptides inhibits KCNQ1. 1 / 1
| 1
reach
"We showed that S4S5 (L) peptides inhibit KCNQ1, in a reversible and state dependent manner."
20940310
S4S5(L) peptides inhibits mutated KCNQ1. 1 / 1
| 1
reach
"S4S5 (L) peptides also inhibited a voltage independent KCNQ1 mutant."
20940310
RL3 affects KCNQ1
| 2
RL3 activates KCNQ1. 2 / 2
| 2
reach
"R-L3 potentiates the homomeric KCNQ1 channel at very low concentration, but does not affect the KCNQ1 and KCNE1 complex."
23251633
reach
"Using a pharmacological tool compound R-L3 (L-364,373 [(3-R) -1,3-dihydro-5-(2-fluorophenyl)-3-(1H-indol- 3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one]), which activates KCNQ1 and mink channels, we then developed and validated a non radioactive rubidium (Rb+) efflux assay that directly measures the functional activity of KCNQ1 and KCNE1 channels by atomic absorption spectroscopy."
16945016
PPP1CA affects KCNQ1
2 |
KCNQ1 binds PPP1CA. 2 / 2
2 |
biogrid
No evidence text available
11799244
biogrid
No evidence text available
11799244
PKCepsilon isoenzymes affects KCNQ1
| 2
PKCepsilon isoenzymes leads to the phosphorylation of KCNQ1. 2 / 2
| 2
reach
"By phosphorylating distinct sites in KCNQ1 and KCNE1, cPKC and PKCepsilon isoenzymes produce contrary regulatory effects on the channel."
29452158
reach
"Our results demonstrate that PKCepsilon isoenzyme mediates the inhibitory action of Ang II on I Ks and by phosphorylating distinct sites in KCNQ1 and KCNE1, cPKC and PKCepsilon isoenzymes produce the contrary regulatory effects on the channel."
29452158
PBA affects KCNQ1
| 2
PBA activates KCNQ1. 2 / 2
| 2
reach
"Analysis of different sized charge carriers revealed that PBA also targets the permeation pathway of KCNQ1 channels."
19156197
reach
"PBA potentiates both the KNCQ1 and the KCNQ1 and KCNE1."
23251633
NOG affects KCNQ1
2 |
NOG increases the amount of KCNQ1.
1 |
Transcriptionally active NOG increases the amount of KCNQ1. 1 / 1
1 |
biopax:ctd
No evidence text available
27188386
NOG decreases the amount of KCNQ1.
1 |
Transcriptionally active NOG decreases the amount of KCNQ1. 1 / 1
1 |
biopax:ctd
No evidence text available
27188386
MiRP1 COOH terminus affects KCNQ1
| 2
MiRP1 COOH terminus activates KCNQ1. 2 / 2
| 2
reach
"Furthermore, using chimeric analysis between two members of the KCNE family, we show that the MiRP1 COOH terminus can modulate KvLQT1 in the presence of the MinK transmembrane domain."
10962015
reach
"The converse chimera consisting of the MiRP1 COOH terminus in a MinK background does modulate KvLQT1, suggesting that the MiRP1 COOH terminus can modulate KvLQT1 gating in concert with the MinK transmembrane domain."
10962015
MYOD1 affects KCNQ1
| 2
MYOD1 increases the amount of KCNQ1.
| 1
MYOD1 increases the amount of KCNQ1. 1 / 1
| 1
reach
"We observed that MyoD also induces the expression of kcnq1, co-imprinted with p57."
22740650
MYOD1 activates KCNQ1.
| 1
MYOD1 activates KCNQ1. 1 / 1
| 1
reach
"In light of the observed biallelic binding, we queried whether the MyoD dependent induction of p57 and kcnq1 involved the up-regulation of the maternal or the de-repression of the paternal imprinted alleles."
22740650
ML277 affects KCNQ1
| 2
ML277 inhibits KCNQ1.
| 1
ML277 inhibits KCNQ1. 1 / 1
| 1
reach
"It is believed that ML277 inhibits the voltage dependent inactivation kinetics of KCNQ1 to contribute to the augmentation of current amplitude while the hyperpolarizing shift of V (1/2) could significantly increase the maximal conductance [XREF_BIBR]."
25889101
ML277 activates KCNQ1.
| 1
ML277 activates KCNQ1. 1 / 1
| 1
reach
"ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling."
31329101
L-735,821 affects KCNQ1
| 2
L-735,821 inhibits KCNQ1. 2 / 2
| 2
reach
"This, in fact, has already been shown by Tinel et al. (1998) for L-735,821, a novel benzodiazepine that inhibits both KCNQ1 (EC 50 = 0.08 muM) and KCNQ2 (EC 50 = 1.5 muM)."
10958929
reach
"L-735,821, a benzodiazepine molecule which inhibits the KCNQ1 channel activity (EC50 = 0.08 microM), also blocks KCNQ2 currents (EC50 = 1.5 microM)."
9827540
KCNQ1 affects voltage-gated potassium channel
| 2
KCNQ1 binds voltage-gated potassium channel. 1 / 1
| 1
sparser
"For example, in male pups the expression of the gene Kcnq1 , a voltage-gated potassium channel, which has been associated with Jervell and Lange-Nielsen syndrome and hereditary long QT syndrome 1 [ xref , xref ], and the gene Tsix that expresses the non-coding antisense transcript required for imprinted X inactivation [ xref ], were down-regulated."
25629700
KCNH2 binds KCNQ1 and voltage-gated potassium channel. 1 / 1
| 1
sparser
"Both LQT1 and LQT2 are associated with loss of function of voltage-gated potassium channels (I Ks and I Kr ). xref "
20728018
KCNQ1 affects translation
| 2
KCNQ1 inhibits translation.
| 1
KCNQ1 inhibits translation. 1 / 1
| 1
reach
"We show that SNPs in the 3 ' UTR of KCNQ1 repress translation, and that these repressive SNPs largely determine the clinical severity in heterozygous carriers of an LQTS linked KCNQ1 mutation."
23595704
KCNQ1 activates translation.
| 1
KCNQ1 activates translation. 1 / 1
| 1
reach
"To explain the presence of LQTS segregating with the t (11; 17) translocation in this family, we hypothesize that the translocation that interrupts KCNQ1 allow translation of an abnormal short allele that interferes in a dominant negative way with the normal isoform 1 of KCNQ1 in the heart (where this allele is not subject to parental imprint)."
23061425
KCNQ1 affects inositol
| 1 1
KCNQ1 binds inositol.
| 1
Inositol binds KCNQ1. 1 / 1
| 1
sparser
"KCNQ1 interaction with sodium-coupled myo-inositol transporters."
28718502
KCNQ1 activates inositol.
| 1
KCNQ1 activates inositol. 1 / 1
| 1
reach
"While KCNQ1 co-expression enhanced SMIT1 myo-inositol uptake, KCNQ1-KCNE2 inhibited it, as did co-expression with R231A-KCNQ1, a constitutively active mutant with the VSD locked in the active state [XREF_BIBR]."
28718502
KCNQ1 affects hydrogen chloride
| 2
KCNQ1 inhibits hydrogen chloride.
| 1
KCNQ1 inhibits hydrogen chloride. 1 / 1
| 1
reach
"Similarly, the compound 293B, a blocker of basolateral KCNQ1 and KCNE3 K (+) channels effectively blocked Cl (-) secretion when applied to either the luminal or basolateral side of the epithelium."
12235489
KCNQ1 activates hydrogen chloride.
| 1
KCNQ1 activates hydrogen chloride. 1 / 1
| 1
reach
"Moreover, pharmacological inhibition of KvLQT1 and KCa3.1 channels was found to strongly reduce Cl - transport in nasal, tracheal, and bronchial cells [XREF_BIBR]."
27092946
KCNQ1 affects Type 1 long QT syndrome
| 2
KCNQ1 inhibits Type 1 long QT syndrome. 2 / 2
| 2
reach
"Type 1 long QT syndrome (LQT1) is caused by loss-of-function mutations in the KCNQ1 encoded Kv7.1 channel that conducts the slowly activating component of the delayed rectifier K + current (I Ks)."
24269949
reach
"Type 1 long QT syndrome (LQT1) accounts for ~ 35% of LQTS and is caused by loss-of-function mutations in the KCNQ1 K + channel (Kv7.1)."
23092362
KCNQ1 affects TYMS
| 2
TYMS binds KCNQ1. 1 / 1
| 1
sparser
"Since there are no cysteine residues in the extracellular domain of KCNE1, it has been proposed that TMS interacts with its partner protein KCNQ1."
11944086
TYMS binds IK and KCNQ1. 1 / 1
| 1
sparser
"The aim of this study was therefore to investigate the interaction of TMS with KCNQ1 and the respective K+current IK."
11944086
KCNQ1 affects TRAF6
1 1 |
TRAF6 binds KCNQ1. 2 / 2
1 1 |
biogrid
No evidence text available
14743216
hprd
No evidence text available
14743216
KCNQ1 affects SQT2
| 2
KCNQ1 inhibits SQT2.
| 1
KCNQ1-V141M inhibits SQT2. 1 / 1
| 1
reach
"Inhibition of I Ks as a potential therapeutic strategy was further tested in another form of SQT2 caused by the KCNQ1 V141M mutation, which differs from the V307L mutation in that it induces a constitutively active voltage independent current component 11."
28814790
KCNQ1 activates SQT2.
| 1
KCNQ1 activates SQT2. 1 / 1
| 1
reach
"SQTS has been associated with the gain-of-function mutations in 3 distinct potassium channels, KCNH2, KCNQ1 and KCNJ2, which cause SQT1, SQT2 and SQT3, respectively [111-114]."
30027834
KCNQ1 affects SQT1
| 2
KCNQ1-V307L activates SQT1. 1 / 1
| 1
reach
"N588K-KCNH2 and V307L KCNQ1 mutations lead to a gain-of-function of IKr and IKs thus causing short-QT syndromes (SQT1, SQT2)."
23718892
KCNQ1 activates SQT1. 1 / 1
| 1
reach
"SQTS has been associated with the gain-of-function mutations in 3 distinct potassium channels, KCNH2, KCNQ1 and KCNJ2, which cause SQT1, SQT2 and SQT3, respectively [111-114]."
30027834
KCNQ1 affects SNP, and SP3
| 2
SP3 binds KCNQ1 and SNP. 2 / 2
| 2
sparser
"Taken together with the data from the in vitro binding assay, these results suggest that Sp3 preferentially binds the non-risk allele of the endogenous KCNQ1 intronic region that contains SNP rs163184."
29207083
sparser
"Sp3 preferentially bound to the non-risk allele of the KCNQ1 SNP rs163184 region and stimulated transcriptional activity of an artificial promoter containing the SNP rs163184 region."
29207083
KCNQ1 affects SMCHD1
| 1 1
KCNQ1 binds SMCHD1. 1 / 1
| 1
isi
"We showed SMCHD1 binding to an intronic region of KCNQ1 that is lost following 5-azaC treatment suggesting DNA methylation facilitated binding of SMCHD1."
31941450
SMCHD1 binds KCNQ1. 1 / 1
| 1
sparser
"We showed SMCHD1 binding to an intronic region of KCNQ1 that is lost following 5-azaC treatment suggesting DNA methylation facilitated binding of SMCHD1."
31941450
KCNQ1 affects SLC5A5
| 1 1
KCNQ1 binds SLC5A5.
| 1
SLC5A5 binds KCNQ1. 1 / 1
| 1
sparser
"Regarding the mechanism of KCNQ1-NIS interaction, we do not yet have confirmation of a physical interaction, although this is suspected."
27098917
KCNQ1 activates SLC5A5.
| 1
KCNQ1 activates SLC5A5. 1 / 1
| 1
reach
"Future investigations will be targeted at understanding exactly how KCNQ1 augments SMIT1 and NIS activity and whether there are underlying mechanistic commonalties."
27098917
KCNQ1 affects SH2B2
| 2
KCNQ1-S140G activates SH2B2. 1 / 1
| 1
reach
"We conclude that the S140G KCNQ1 mutation would be predicted to augment substantially repolarising current both early and throughout atrial APs and, in principle, also to influence markedly ventricular AP repolarisation."
21224508
KCNQ1 activates SH2B2. 1 / 1
| 1
reach
"Each of I KCNQ1, I KCNQ4 or I hERG contributed to the ability of the modified USMC model to produce longer bursting APs."
25474527
KCNQ1 affects PRKACA
2 |
KCNQ1 binds PRKACA. 2 / 2
2 |
biogrid
No evidence text available
11799244
biogrid
No evidence text available
11799244
KCNQ1 affects PPP1CA
2 |
KCNQ1 binds PPP1CA. 2 / 2
2 |
biogrid
No evidence text available
11799244
biogrid
No evidence text available
11799244
KCNQ1 affects Long-QT syndrome type 1
| 2
KCNQ1 activates Long-QT syndrome type 1. 2 / 2
| 2
reach
"Long-QT syndrome type 1 (LQT1) is caused by mutations in KCNQ1, which encodes the alpha-subunit of the slow delayed rectifier potassium current (I Ks) channel."
29857160
reach
"Long-QT syndrome type 1 (LQT1) is caused by mutations in the KCNQ1 gene resulting in a decrease in the repolarizing potassium current IKs."
26318259
KCNQ1 affects LQTS2
| 2
KCNQ1 inhibits LQTS2.
| 1
KCNQ1 inhibits LQTS2. 1 / 1
| 1
reach
"Moreover, KCNQ1 antibodies were able to restore alterations in cardiac repolarization and most importantly tosuppress arrhythmias in LQTS2."
32354382
KCNQ1 activates LQTS2.
| 1
KCNQ1 activates LQTS2. 1 / 1
| 1
reach
"Mutations in KCNQ1 and HERG cause the congenital LQTS1 XREF_BIBR and LQTS2, XREF_BIBR respectively."
20348026
KCNQ1 affects LQTS type 1
| 2
KCNQ1 activates LQTS type 1. 2 / 2
| 2
reach
"LQTS type 1 (LQT1) is caused by a mutation in the KCNQ1 gene, which encodes for a subunit of the ion channel responsible for the adrenergic sensitive, slow outward potassium current, I Ks."
28007615
reach
"LQTS type 1 (LQT1), one of the most common forms of LQTS, is caused by mutations in the slow potassium current (I (Ks)) channel alpha subunit KCNQ1."
21451124
KCNQ1 affects LQT3
| 2
KCNQ1 activates LQT3. 2 / 2
| 2
reach
"Among them most common are LQT1, LQT2, and LQT3, caused by mutations in KCNQ1, KCNH2, and SCN5A genes, respectively (Splawski etal."
28944242
reach
"LQT1, LQT2, and LQT3 are caused by mutations in KCNQ1 (LQT1), KCNH2 (LQT2), and SCN5A (LQT3), which account for approximately 90% of genotyped LQTS patients."
26282245
KCNQ1 affects LQT
| 2
KCNQ1 binds LQT.
| 1
KCNQ1 binds LQT. 1 / 1
| 1
reach
"Hence, a consistent association between KCNQ1 and LQT and epilepsy remains to be demonstrated.Here we report a family showing the association of epilepsy concomitant with LQTS."
25645639
KCNQ1 activates LQT.
| 1
KCNQ1 activates LQT. 1 / 1
| 1
reach
"Mutations in KVLQT1, HERG, SCN5A, and KCNE1, genes encoding cardiac ion channels, cause LQT."
9693036
KCNQ1 affects Kr
| 2
KCNQ1 inhibits Kr.
| 1
KCNQ1 inhibits Kr. 1 / 1
| 1
reach
"Taken together, KCNQ1 (including KCNQ1 R174C mutant channels) attenuated I Kr when co-expressed with hERG."
29449639
KCNQ1 activates Kr.
| 1
KCNQ1 activates Kr. 1 / 1
| 1
reach
"Mutations in the KCNQ1 and HERG genes cause the Long QT Syndromes, LQTS1 and LQTS2, due to reductions in the cardiac repolarizing I Ks and I Kr currents, respectively."
20348026
KCNQ1 affects KCNE proteins
| 2
KCNQ1 binds KCNE proteins. 2 / 2
| 2
reach
"Although it has been known that KCNE proteins interact with KCNQ1 via the pore domain, some recent reports suggest that the VSD movement may be altered by KCNE."
25603957
reach
"XREF_BIBR, XREF_BIBR Heterologous expression experiments have demonstrated that KCNE proteins alter the properties of several K V channels, XREF_BIBR - XREF_BIBR and that all KCNE proteins (KCNE1-KCNE5) interact with KCNQ1 (K V 7.1), each yielding a distinct phenotype."
20139709
KCNQ1 affects JLN1
| 2
Mutated KCNQ1 activates JLN1. 1 / 1
| 1
reach
"Homozygous or compound heterozygous mutations of KCNQ1 also cause Jervell and Lange-Nielsen form of LQTS (JLN1) [XREF_BIBR]."
18478063
KCNQ1 activates JLN1. 1 / 1
| 1
reach
"Homozygous or compound heterozygous mutation in either KCNQ1 or KCNE1 (minK) causes the Jervell and Lange-Nielsen autosomal recessive form of the disease (JLN1 and JLN2, respectively), which is characterized by cardiac phenotype (long QT interval and susceptibility to ventricular arrhythmia) and sensorineural deafness."
20890437
KCNQ1 affects IKs
| 2
KCNQ1 inhibits IKs.
| 1
KCNQ1 inhibits IKs. 1 / 1
| 1
reach
"Mutations in KCNQ1 reduce IKs and cause long-QT syndrome, a disorder of ventricular repolarization that predisposes affected individuals to arrhythmia and sudden death."
14576198
KCNQ1 activates IKs.
| 1
KCNQ1 activates IKs. 1 / 1
| 1
reach
"Therefore, tKvLQT1 may modulate the function of IKs in human cardiac myocytes."
9305853
KCNQ1 affects I Ks
| 2
KCNQ1 inhibits I Ks. 2 / 2
| 2
reach
"Therefore, KCNQ1 -G269S might minimally affect I Ks at rest but impair the up-regulation of I Ks by PKA, because the exercise stress (PKA activation) does not prolong the QTc interval in control subjects (13)."
24184248
reach
"The co-expression of KCNE1-S38G and KCNQ1 decreased tail current density of I Ks but had little effect in modulation channel kinetics of I Ks."
29395134
KCNQ1 affects HMR-1556
| 2
KCNQ1 activates HMR-1556. 2 / 2
| 2
reach
"Wild-type (WT) KCNQ1 or the familial AF mutation KCNQ1 S140G were heterologously co-expressed with KCNE1 to enable electrophysiological recording of the slow delayed rectifier current (I Ks) and investigation of pharmacological effects of the I Ks selective blocker HMR-1556."
24006450
reach
"Wild-type (WT) KCNQ1 or the familial atrial fibrillation mutation KCNQ1 S140G was heterologously coexpressed with KCNE1 to enable electrophysiological recording of the slow delayed rectifier current (IKs) and investigation of pharmacological effects of the IKs selective blocker HMR-1556."
24006450
KCNQ1 affects GNPTAB
| 2
GNPTAB binds KCNQ1. 1 / 1
| 1
sparser
"Flexibility in KCNQ1’s β-subunits association, both in number and in type, allows for a powerful mechanism to modulate repolarization in the heart through changes in expression."
26802629
GNPTAB binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"The data we present here characterize a physical and functional interaction between the two K + channel subunits, KCNQ1 and KCNE1 residing in their intracellular C-termini."
20196769
KCNQ1 affects GCG
| 2
KCNQ1 decreases the amount of GCG.
| 1
KCNQ1 decreases the amount of GCG. 1 / 1
| 1
reach
"Subjects with the type-2 diabetes associated KCNQ1 SNP rs151290 (C) also have significantly reduced GLP-1 levels in response to oral glucose, compared with controls [XREF_BIBR]."
22134088
KCNQ1 activates GCG.
| 1
KCNQ1 activates GCG. 1 / 1
| 1
reach
"Wolfram syndrome 1 gene (WFS1) has been associated with type 2 diabetes and with impaired insulin secretion during a GLP-1 infusion, and the variant rs151290 in KCNQ1 has been associated with changes in insulin secretion and increased GIP and GLP-1 secretion."
21525464
KCNQ1 affects FTO
| 2
FTO binds KCNQ1. 1 / 1
| 1
sparser
"In particular, it has been suggested that the interaction of the FTO or KCNQ1 genes with environmental factors increases the incidence of diabetes."
30603301
TCF7L2 binds FTO, GCKR, and KCNQ1. 1 / 1
| 1
sparser
"xref shows that TCF7L2 , CDKN2BAS , KCNQ1 , FTO and GCKR are significantly associated with IFH (OR ranged between 1.171–1.524; p value ranged between 0.0023–0.0476)."
23990951
KCNQ1 affects F57Bpa
| 2
KCNQ1 binds F57Bpa. 2 / 2
| 2
reach
"Since F57Bpa interacts with KCNQ1 in the channel 's closed state, we used this observation to test whether an independently expressed F57Bpa KCNE1 beta-subunit could enter an open cleft in EQQQQ or EQQ and crosslink with the channel."
26802629
reach
"To determine if F57Bpa directly interacts with KCNQ1, a 300 ms flash of UV light (365 nm) was applied while holding at -90 mV followed by a 4s activation step (+60 mV) and repeated with each successive sweep (XREF_FIG)."
26802629
KCNQ1 affects EAF2
| 2
KCNQ1 binds EAF2.
| 1
EAF2 binds KCNQ1. 1 / 1
| 1
reach
"However, we did not find evidence of association between KCNQ1 and diabetic related quantitative traits."
29871606
KCNQ1 activates EAF2.
| 1
KCNQ1 activates EAF2. 1 / 1
| 1
reach
"Current knowledge of the KCNQ1 protein in INS-1-cells and the association of the KCNQ1 polymorphisms with type 2 diabetes in two large Japanese studies XREF_BIBR, XREF_BIBR led us to investigate a role for these variants in type 2 diabetes related quantitative traits (especially serum insulin release) in the population based Inter99 study sample."
19516902
KCNQ1 affects DERL1
| 1 1
KCNQ1 inhibits DERL1.
| 1
KCNQ1 inhibits DERL1. 1 / 1
| 1
reach
"LQT1 associated mutations increase KCNQ1 proteasomal degradation independently of Derlin-1."
19114714
KCNQ1 binds DERL1.
| 1
DERL1 binds KCNQ1. 1 / 1
| 1
sparser
"Small interfering RNA knock-down of Derlin-1 did not modify KCNQ1 expression level, and no interaction between endogenous KCNQ1 and Derlin-1 could be detected."
19114714
KCNQ1 affects C-peptide
| 2
KCNQ1 inhibits C-peptide. 2 / 2
| 2
reach
"Loss-of-function mutations in KCNQ1 causes long QT syndrome along with glucose stimulated hyperinsulinemia, increased C-peptide and postprandial hypoglycemia."
32164657
reach
"Loss-of-function mutations in KCNQ1 causes long QT syndrome along with glucose stimulated hyperinsulinemia, increased C-peptide and postprandial hypoglycemia."
32164657
KCNQ1 affects BACE1
2 |
KCNQ1 binds BACE1. 2 / 2
2 |
biogrid
No evidence text available
26454161
biogrid
No evidence text available
26454161
KCNQ1 affects Ala-Pro
| 2
KCNQ1-S140G activates Ala-Pro. 2 / 2
| 2
reach
"Thus : (i) the S140G KCNQ1 mutation was found to abbreviate atrial AP duration and effective refractory period and this is causally linked to a substrate favourable to re-entry; (ii) selective K channel blockade was found to mitigate the effect of the S140G KCNQ1 mutation on atrial electrophysiology, with a simulated reduction in I Ks but not I Kr having marked effects at single cell and tissue levels (iii) the S140G KCNQ1 mutation can produce ventricular AP abbreviation, though this effect seems to be model specific."
24411289
reach
"We conclude that the S140G KCNQ1 mutation would be predicted to augment substantially repolarising current both early and throughout atrial APs and, in principle, also to influence markedly ventricular AP repolarisation."
21224508
KCNQ1 affects ATP
| 1 2
ATP binds KCNQ1. 2 / 2
| 1 2
reach
"Furthermore, the second component of IKs inhibition by Ci-VSP was reduced by AMP-PCP in the pipette filling solution, indicating that direct binding of ATP to the KCNQ1 and KCNE1 complex is required for voltage activation of IKs."
25892084
reach
"We demonstrate that intracellular ATP is a more potent modulator of I Ks activity than PIP 2, supporting the notion that direct binding of ATP to the KCNQ1 and KCNE1 channel is essential for channel activation [23]."
25892084
KCNQ1 affects AC2
| 2
KCNQ1 binds AC2. 2 / 2
| 2
reach
"AC2 expression has been reported in cardiac myocytes and can associate with KCNQ1 and Yotiao (important in modulating the slow delayed rectifier current contributing to the late-phase repolarization of the cardiac action potential), 30 but its specific physiologic role has yet to be determined."
27427220
reach
"We now show that either AC2 or AC9 can associate with KCNQ1 in a complex mediated by Yotiao."
22778270
KCNQ1 affects ABCC1
| 2
ABCC1 binds KCNQ1. 1 / 1
| 1
sparser
"In the study reported by Chen et al. xref , the authors found that subjects with minor alleles of SNPs rs2283228 and rs2237892 in the KQT-like subfamily member 1 ( KCNQ1 ) gene, which were associated with type 2 diabetes, had higher levels of TG."
24474964
ABCC1 binds KCNA1 and KCNQ1. 1 / 1
| 1
sparser
"Polymorphisms in intron 15 of potassium voltage-gated channel, KQT-like subfamily member 1 ( KCNQ1 ) gene have been associated with type II diabetes (T2D) in Japanese genome-wide association studies (GWAS)."
21261977
KCNH2 affects KCNJ2, KCNQ1, and PSMD4
| 2
KCNH2 binds KCNJ2, KCNQ1, and PSMD4. 2 / 2
| 2
sparser
"In addition, AF has been associated with rare gain of function mutations in KCNQ1, hERG and KCNJ2 causing the short QT syndrome and sudden death."
16887036
sparser
"This is largely due to reduced L-type Ca 2+ current, although rare gain-of-function mutations in KCNQ1 [ xref ], hERG [ xref ], Kir2.1 [ xref ] and KCNE ancillary subunits [ xref ] have also been associated with AF due to increases in channel conductance."
20670193
KCNE4S-145D affects KCNQ1
| 2
KCNE4S-145D inhibits KCNQ1. 2 / 2
| 2
reach
"In Xenopus oocytes, human KCNE4S-145D inhibited KCNQ1 activity by 80%, while human KCNE4L-145D inhibited KCNQ1 by 40%, differing from the previous results reported for KCNE4-145D in CHO cells 42 (although there was no direct comparison of the D versus E polymorphisms)."
27484720
reach
"In Xenopus oocytes, human KCNE4S-145D inhibited KCNQ1 activity by 80%, while human KCNE4L-145D inhibited KCNQ1 by 40%, differing from the previous results reported for KCNE4-145D in CHO cells (Abbott, 2016b) (although there was no direct comparison of the D versus E polymorphisms)."
27484720
KCNE4L-145D affects KCNQ1
| 2
KCNE4L-145D inhibits KCNQ1. 2 / 2
| 2
reach
"In Xenopus oocytes, human KCNE4S-145D inhibited KCNQ1 activity by 80%, while human KCNE4L-145D inhibited KCNQ1 by 40%, differing from the previous results reported for KCNE4-145D in CHO cells (Abbott, 2016b) (although there was no direct comparison of the D versus E polymorphisms)."
27484720
reach
"In Xenopus oocytes, human KCNE4S-145D inhibited KCNQ1 activity by 80%, while human KCNE4L-145D inhibited KCNQ1 by 40%, differing from the previous results reported for KCNE4-145D in CHO cells 42 (although there was no direct comparison of the D versus E polymorphisms)."
27484720
KCNE peptides affects KCNQ1
| 2
KCNE peptides activates KCNQ1. 2 / 2
| 2
reach
"All five KCNE peptides have been shown to assemble with and differentially modulate KCNQ1 (Q1) K + channels."
17130521
reach
"In total, these results suggest that KCNE peptides differently modulate the voltage sensor in KCNQ1 K (+) channels."
18079560
KCN affects KCNE2, and KCNQ1
| 2
KCN binds KCNE2 and KCNQ1. 2 / 2
| 2
sparser
"Here, we show that the potassium channel subunits KCNQ1 and KCNE2 form a thyroid-stimulating hormone-stimulated, constitutively active, thyrocyte K+ channel required for normal thyroid hormone biosynthesis."
19767733
sparser
"Kcne2 colocalized and coimmunoprecipitated with Kcnq1 in mouse lungs, suggesting the formation of pulmonary Kcnq1-Kcne2 potassium channel complexes."
31162977
KCN affects KCNE1, and KCNQ1
| 2
KCN binds KCNE1 and KCNQ1. 2 / 2
| 2
sparser
"Genetic defect is located in the KCNQ1 and KCNE1 (LQT1) genes that form the slow component of the delayed rectifier potassium channel complex (90 and 10% of cases, resp.)."
22013448
sparser
"KvLQT1 and minK associate to form the functional slowly activated delayed rectifier potassium channel ( I Ks ) [12,13] while HERG and MiRP1 associate to form the rapidly activated delayed rectifier potassium channel ( I Kr ) [10] ."
12051962
JPH2 affects KCNQ1
| 2
JPH2 binds KCNQ1.
| 1
JPH2 binds KCNQ1. 1 / 1
| 1
reach
"JPH-2 also interacts with Cav1.2 and KCNQ1, the pore forming subunits of L-type Ca (I CaL) and slow delayed rectifier (I Ks) channels."
26538326
JPH2 activates KCNQ1.
| 1
JPH2 activates KCNQ1. 1 / 1
| 1
reach
"JPH-2 does not alter whole cell KCNQ1 protein level, but increases% of KCNQ1 on the cell surface while decreasing the KCNQ1 and I Ks current amplitudes."
26538326
IGF2 affects KCNQ1
| 2
IGF2 binds KCNQ1. 2 / 2
| 2
sparser
"These functional associations of IGF2 and KCNQ1 rely on publications reporting how a differentially methylated region in KCNQ1 controls imprinted expression of other genes in the neighborhood xref and about epigenetic abnormalities in the IGF2/H19 region of Beckwith-Wiedemann syndrome patients xref ."
23226257
sparser
"Our results suggest that the aberrant methylation of IGF2 and KCNQ1 genes may be associated with sperm DNA damage."
30680773
Histone affects KCNQ1
| 2
Histone methylates KCNQ1.
| 1
Histone methylates KCNQ1. 1 / 1
| 1
reach
"Kcnq1ot1 induces transcriptional silencing by histone methylation of the overlapping Kcnq1 and Kv7.1 potassium channel gene and other genes at the same genomic locus XREF_BIBR - XREF_BIBR."
28367094
Histone inhibits KCNQ1.
| 1
Histone inhibits KCNQ1. 1 / 1
| 1
reach
"Kcnq1ot1 interacts with PRC2 as well as the H3K9 specific histone methyltransferase G9a in a lineage specific manner to mediate the silencing of the Kcnq1 gene in the paternal allele in placenta."
24342564
HeTx204 affects KCNQ1
| 2
HeTx204 inhibits KCNQ1. 2 / 2
| 2
reach
"Toxins ImKTx104 and HeTx204 effectively blocked the KCNQ1 channel at 10 microM concentration, while LmKTx2 and HeTx203 only weakly inhibited the KCNQ1 channel at the same concentration, and 10 microM StKTx23 did not inhibit KCNQ1 channels."
22511981
reach
"Acidic ImKTx104 is a selective KCNQ1 channel inhibitor, whereas HeTx204 can block both Kv1.3 and KCNQ1 channels."
22511981
GYG1 affects KCNQ1
| 2
GYG1 inhibits KCNQ1.
| 1
GYG1 inhibits KCNQ1. 1 / 1
| 1
reach
"A triple alanine mutation of the " GYG "-motif in the KCNQ1 pore was introduced to produce a comparator KCNQ1 mutation (dominant negative KCNQ1 [dnKCNQ1])."
19959132
GYG1 activates KCNQ1.
| 1
GYG1 activates mutated KCNQ1. 1 / 1
| 1
reach
"A triple alanine mutation of the " GYG "-motif in the KCNQ1 pore was introduced to produce a comparator KCNQ1 mutation (dominant negative KCNQ1 [dnKCNQ1])."
19959132
GS26575 affects KCNQ1
| 2
GS26575 inhibits KCNQ1. 2 / 2
| 2
reach
"Furthermore, invalidation of the KCNQ1 S92 consensus phosphorylation site completely abolished the PKA effect on M1 inhibition of KCNQ1 and KCNE1 currents."
22787448
reach
"PKA modulation of wortmannin inhibition was similar to the PKA modulation of M1 inhibition of KCNQ1."
22787448
GRB10 affects KCNQ1
| 1 1
GRB10 inhibits KCNQ1.
| 1
GRB10 inhibits KCNQ1. 1 / 1
| 1
reach
"Only Grb10 significantly inhibited KCNQ1 and KCNE1 K (+) channels, and only Grb7 reduced Kir2.3 activity, whereas neither Grb protein significantly affected the closely related Kir2.1 and Kir2.2 channels."
19371729
GRB10 binds KCNQ1.
| 1
XIST binds YY1, GRB10, KCNQ1, and RASGRF1. 1 / 1
| 1
sparser
"So far, two transcription factors are known to bind to DMRs: CTCF binds to the DMRs of H19 , Kcnq1 , Rasgrf1 , Grb10 , Dlk1/Gtl2 , Tsix and Xist , and YY1 binds to the DMRs of Nespas , Xist , Tsix and Peg3 ( xref )."
19628663
GNPTAB affects KCNQ1
| 2
GNPTAB binds KCNQ1. 1 / 1
| 1
sparser
"Flexibility in KCNQ1’s β-subunits association, both in number and in type, allows for a powerful mechanism to modulate repolarization in the heart through changes in expression."
26802629
GNPTAB binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"The data we present here characterize a physical and functional interaction between the two K + channel subunits, KCNQ1 and KCNE1 residing in their intracellular C-termini."
20196769
FTO affects KCNQ1
| 2
FTO binds KCNQ1. 1 / 1
| 1
sparser
"In particular, it has been suggested that the interaction of the FTO or KCNQ1 genes with environmental factors increases the incidence of diabetes."
30603301
TCF7L2 binds FTO, GCKR, and KCNQ1. 1 / 1
| 1
sparser
"xref shows that TCF7L2 , CDKN2BAS , KCNQ1 , FTO and GCKR are significantly associated with IFH (OR ranged between 1.171–1.524; p value ranged between 0.0023–0.0476)."
23990951
F57Bpa affects KCNQ1
| 2
KCNQ1 binds F57Bpa. 2 / 2
| 2
reach
"Since F57Bpa interacts with KCNQ1 in the channel 's closed state, we used this observation to test whether an independently expressed F57Bpa KCNE1 beta-subunit could enter an open cleft in EQQQQ or EQQ and crosslink with the channel."
26802629
reach
"To determine if F57Bpa directly interacts with KCNQ1, a 300 ms flash of UV light (365 nm) was applied while holding at -90 mV followed by a 4s activation step (+60 mV) and repeated with each successive sweep (XREF_FIG)."
26802629
EGFR affects KCNQ1
1 | 1
EGFR inhibits KCNQ1.
| 1
EGFR inhibits KCNQ1. 1 / 1
| 1
reach
"These results indicate that the reduction of tyrosine phosphorylation in KCNQ1 protein caused by EGFR kinase inhibition can be countered by inhibiting protein tyrosine phophatases."
20085748
EGFR binds KCNQ1.
1 |
EGFR binds KCNQ1. 1 / 1
1 |
biogrid
No evidence text available
28065597
EGF affects KCNQ1
| 2
EGF increases the amount of KCNQ1.
| 1
EGF increases the amount of KCNQ1. 1 / 1
| 1
reach
"The biochemical experiments also showed that tyrosine phosphorylation level of the recombinant KCNQ1 was not enhanced by EGF or orthovanadate in cells cultured with a normal medium; however, the tyrosine phosphorylation level was reduced in the cells cultured with serum-free medium for 36-h, even the reduction was not statistically significance."
20085748
EGF activates KCNQ1.
| 1
EGF activates KCNQ1. 1 / 1
| 1
reach
"Finally, EGF stimulated K (ATP) and KvLQT1 currents and channel expression."
17631610
DDX41 affects KCNQ1
| 2
DDX41 activates KCNQ1. 2 / 2
| 2
reach
"We used rabbit and mouse Abs targeting KCNQ1 and KCNE1, respectively, followed by Alexa488- and Alexa568 conjugated secondary Abs targeting rabbit and mouse IgG."
30075281
reach
"We used rabbit and mouse Abs targeting KCNQ1 and KCNE1, respectively, followed by Alexa488- and Alexa568 conjugated secondary Abs targeting rabbit and mouse IgG."
30075281
CFH affects KCNQ1
| 2
CFH inhibits KCNQ1.
| 1
CFH inhibits KCNQ1. 1 / 1
| 1
reach
"Dyssynchronous HF reduces repolarizing potassium currents, including the inward rectifier K + current (I K1), transient outward K + current (I to), and delayed rectifier K + current (I K) [XREF_BIBR], concordant with less protein expression in corresponding channel proteins : Kir 2.1, Kv4.3 and KChIP2, and KvLQT1, respectively."
26596804
CFH decreases the amount of KCNQ1.
| 1
CFH decreases the amount of KCNQ1. 1 / 1
| 1
reach
"KvLQT1 expression was reduced by 69% in the HF group and in the Biso by 56%."
23554701
CDKAL1 affects KCNQ1, and SLC30A8
| 2
SLC30A8 binds CDKAL1 and KCNQ1. 2 / 2
| 2
sparser
"In our present study, the findings support the individual associations of CDKN2A/2B (rs10811661), SLC30A8 (rs13266634 and rs2466293), CDKAL1 (rs7756992) and KCNQ1 (rs2237892) with not only T2DM but also IGR in a case-control study."
21103332
sparser
"We found that CDKAL1 (rs7756992), SLC30A8 (rs13266634, rs2466293), CDKN2A/2B (rs10811661) and KCNQ1 (rs2237892) were associated with T2DM with odds ratio from 1.21 to 1.35."
21103332
AT1R affects KCNQ1
| 2
AT1R activates KCNQ1. 2 / 2
| 2
reach
"Persistent AT1R stimulation promotes KCNQ1 trafficking to cell surface in a Ca- and calmodulin dependent manner."
28611207
reach
"Biotinylation experiments show that AT1R stimulation fails to increase cell surface KCNQ1 under these two conditions (XREF_FIG, 2 right panels)."
28611207
AKAP9 affects KCNQ1, and PKA
| 2
PKA binds AKAP9 and KCNQ1. 2 / 2
| 2
sparser
"We have previously shown that adenylyl cyclase Type 9 (AC9) is associated with a KCNQ1-Yotiao-PKA complex and facilitates isoproterenol-stimulated phosphorylation of KCNQ1 in an immortalized cell line."
31461851
sparser
"Molecular mechanistic studies showed that this mutation partially inhibits protein-protein interactions of KCNQ1-AKAP9, leading to decreased PKA-mediated phosphorylation of KCNQ1."
29370121
AICA ribonucleotide affects KCNQ1
| 2
AICA ribonucleotide ubiquitinates KCNQ1.
| 1
AICA ribonucleotide leads to the ubiquitination of KCNQ1. 1 / 1
| 1
reach
"AICAR treatment also induced increased ubiquitination of KCNQ1 immunoprecipitated from kidney slice homogenates."
20861072
AICA ribonucleotide activates KCNQ1.
| 1
AICA ribonucleotide activates KCNQ1. 1 / 1
| 1
reach
"Moreover, AICAR treatment of rat kidney slices ex vivo induced AMPK activation and intracellular redistribution of KCNQ1 from the basolateral membrane in collecting duct principal cells."
20861072
ADCY9 affects AKAP9, and KCNQ1
| 2
ADCY9 binds AKAP9 and KCNQ1. 2 / 2
| 2
sparser
"Importantly, formation of a KCNQ1–yotiao–AC9 complex sensitized KCNQ1 to β-adrenergic receptor stimulation, allowing the channel to respond to significantly lower concentrations of agonist ( xref )."
24378903
sparser
"The interaction of AC9 with Yotiao and KCNQ1 was shown by immunoprecipitation of the complex from cells co-expressing all three proteins, a transgenic mouse line with cardiac expression of KCNQ1–KCNE1, and from guinea pig hearts, which endogenously express the complex."
29367580
AC2 affects KCNQ1
| 2
KCNQ1 binds AC2. 2 / 2
| 2
reach
"AC2 expression has been reported in cardiac myocytes and can associate with KCNQ1 and Yotiao (important in modulating the slow delayed rectifier current contributing to the late-phase repolarization of the cardiac action potential), 30 but its specific physiologic role has yet to be determined."
27427220
reach
"We now show that either AC2 or AC9 can associate with KCNQ1 in a complex mediated by Yotiao."
22778270
ABCC1 affects KCNQ1
| 2
ABCC1 binds KCNQ1. 1 / 1
| 1
sparser
"In the study reported by Chen et al. xref , the authors found that subjects with minor alleles of SNPs rs2283228 and rs2237892 in the KQT-like subfamily member 1 ( KCNQ1 ) gene, which were associated with type 2 diabetes, had higher levels of TG."
24474964
ABCC1 binds KCNA1 and KCNQ1. 1 / 1
| 1
sparser
"Polymorphisms in intron 15 of potassium voltage-gated channel, KQT-like subfamily member 1 ( KCNQ1 ) gene have been associated with type II diabetes (T2D) in Japanese genome-wide association studies (GWAS)."
21261977
A568VJAK3 affects KCNQ1
| 2
A568VJAK3 inhibits KCNQ1.
| 1
A568VJAK3 inhibits KCNQ1. 1 / 1
| 1
reach
"Inhibition of KCNE1 and KCNQ1 protein insertion into the cell membrane by brefeldin A (5 microM) resulted in a decline of the voltage gated current, which was similar in the absence and presence of A568VJAK3, suggesting that A568VJAK3 did not accelerate KCNE1 and KCNQ1 protein retrieval from the cell membrane."
26666518
A568VJAK3 activates KCNQ1.
| 1
A568VJAK3 activates KCNQ1. 1 / 1
| 1
reach
"KCNE1 and KCNQ1 activity was significantly increased by wild-type JAK3 and A568VJAK3, but not by K851AJAK3."
26666518
10muM UCL2077 affects KCNQ1
| 2
10muM UCL2077 inhibits KCNQ1. 1 / 1
| 1
reach
"Application of 10muM UCL2077 drastically reduces current of both KCNQ1 and KCNQ1 S140G (XREF_FIG)."
28383569
10muM UCL2077 inhibits KCNQ1-S140G. 1 / 1
| 1
reach
"Application of 10muM UCL2077 drastically reduces current of both KCNQ1 and KCNQ1 S140G (XREF_FIG)."
28383569
YA affects KCNQ1
| 1
KCNQ1 binds yA. 1 / 1
| 1
sparser
"5 Coimmunoprecipitations of the KCNQ1 PY motif mutant (KCNQ1-YA) revealed that USP2-45 and -69 can also bind to KCNQ1-YA, indicating that this interaction is independent of the PY motif ( Figure 3 B)."
22024150
Triglyceride affects KCNQ1
| 1
Triglyceride binds KCNQ1. 1 / 1
| 1
reach
"Similar to this, data from a Mexican population suggested significant associations between KCNQ1 and TG and HDL-C [XREF_BIBR]."
32016123
Trans-aconitic acid affects KCNQ1
| 1
Trans-aconitic acid decreases the amount of KCNQ1. 1 / 1
| 1
reach
"Acid suppression by proton pump inhibitors enhances aquaporin-4 and KCNQ1 expression in gastric fundic parietal cells in mouse."
20437101
Toxins LmKTx2 affects KCNQ1
| 1
Toxins LmKTx2 inhibits KCNQ1. 1 / 1
| 1
reach
"After screening five newly identified acidic peptides and three known peptides (BmP01, BmP02, and PbTx1), we found that each of the acidic toxins had different effects on KCNQ1 : toxin ImKTx104 was the first selective inhibitor of KCNQ1 with a K d of 11.69 microM; toxin HeTx204 blocked Kv1.3 and KCNQ1 at micromolar concentration; toxins LmKTx2, HeTx203, BmP02, and PbTx1 could weakly inhibit KCNQ1 at 10 microM level; and toxins StKTx23 and BmP01 had a minor effect on KCNQ1 at 10 microM concentration."
22511981
Toxin affects KCNQ1
| 1
Toxin inhibits KCNQ1. 1 / 1
| 1
sparser
"Here, we describe the derivatization of a scorpion toxin that irreversibly inhibits KCNQ1 (Q1) K+ channel complexes that contain a specific KCNE peptide."
17602620
Thromboxane A2 affects KCNQ1
| 1
Thromboxane A2 activates KCNQ1. 1 / 1
| 1
reach
"However, even if PGE 2 and TXA 2 stimulate KCNQ1 and KCNE3 channel activity in active UC, this is not accompanied by an overall Cl - secretory response, as net colonic Cl - secretion does not occur in patients with this disease XREF_BIBR, XREF_BIBR."
26718405
Thimerosal affects KCNQ1
| 1
Thimerosal activates KCNQ1. 1 / 1
| 1
reach
"The oxidant thimerosal modulates gating behavior of KCNQ1 by interaction with the channel outer shell."
11944086
Tetramethylsilane affects KCNQ1
| 1
Tetramethylsilane binds KCNQ1. 1 / 1
| 1
reach
"Since there are no cysteine residues in the extracellular domain of KCNE1, it has been proposed that TMS interacts with its partner protein KCNQ1."
11944086
Testosterone affects KCNQ1
| 1
Testosterone increases the amount of KCNQ1. 1 / 1
| 1
reach
"Expression of Kv7.1 (KCNQ1) mRNA was significantly upregulated by testosterone in cardiomyocytes of male and female rats."
29332211
Tat affects KCNQ1
| 1
Tat inhibits KCNQ1. 1 / 1
| 1
reach
"In myocytes, Tat accelerates hERG and KCNE1 and KCNQ1 deactivation, thereby increasing action potential duration 22."
29884859
Tanshinone IIA affects KCNQ1
| 1
Tanshinone IIA activates KCNQ1. 1 / 1
| 1
reach
"These results indicate that tanshinone IIA directly and specifically activate human cardiac KCNQ1 and KCNE1 potassium channels (I (Ks)) in HEK 293 cell through affecting the channels ' kinetics."
18573250
T-AUCB affects KCNQ1
| 1
T-AUCB increases the amount of KCNQ1. 1 / 1
| 1
reach
"T-AUCB upregulated KCNQ1 and KCNH2 mRNA expression dose-dependently."
29843720
Stimulating hormone affects KCNQ1
| 1
Stimulating hormone increases the amount of KCNQ1. 1 / 1
| 1
reach
"We found that KCNQ1-KCNE2 channels are expressed on the basolateral side of thyroid epithelial cells, and that thyroid stimulating hormone (TSH) stimulates protein expression of KCNQ1 and KCNE2, and increases in the FRTL5 thyroid epithelial cell line a K + current with the electrophysiological and pharmacological characteristics of KCNQ1-KCNE2."
26123744
Spn-A affects KCNQ1
| 1
KCNQ1 binds spn-A. 1 / 1
| 1
sparser
"The CAGA haplotype more frequent among BWS patients was associated with loss of methylation of an exon 10 DMR (KvDMR1) in the maternally imprinted KCNQ1 gene ( xref )."
20639793
Sodium(1+) affects KCNQ1
| 1
Sodium(1+) binds KCNQ1. 1 / 1
| 1
reach
"KCNQ1 interaction with sodium coupled myo-inositol transporters."
28718502
Simvastatin affects KCNQ1
| 1
Simvastatin inhibits KCNQ1. 1 / 1
| 1
reach
"Simvastatin inhibited cholesterol synthesis and decreased I KCNQ1 and I (Ks)."
23424208
Similar model developed rabbit heart affects KCNQ1
| 1
Similar model developed rabbit heart inhibits KCNQ1. 1 / 1
| 1
eidos
"A similar model , developed in the rabbit heart , exhibits electrical remodeling with prolonged QT interval , spontaneous torsades des pointes ( TdP ) in 75 % of bradypaced rabbits , reduced I Ks and I Kr , and downregulated KvLQT1 , minK and HERG [ 12 ] ."
32288771
Side affects KCNQ1
| 1
Side activates KCNQ1. 1 / 1
| 1
reach
"A total synthetic approach was used for the preparation of side chain modified derivatives, that slowed down KCNQ1 and KCNE1 channel deactivation to different degrees."
32338831
Sevoflurane affects KCNQ1
| 1
Sevoflurane activates KCNQ1. 1 / 1
| 1
reach
"The hypothesis that volatile anesthetics act on channel protein is, however, not yet confirmed.In conclusion, the volatile anesthetics isoflurane and sevoflurane cause potency dependent reductions in I Ks and KvLQT1 currents, and this result is consistent with the clinical observations that volatile anesthetics prolong the ventricular repolarization (Q-T interval)."
12616988
SEHi t-AUCB affects KCNQ1
| 1
SEHi t-AUCB increases the amount of KCNQ1. 1 / 1
| 1
reach
"More important, we further demonstrated that sEHi t-AUCB could restore the expression of KCNQ1 and KCNH2 mRNA, which were repressed by the agonist miR-133 agomir."
29843720
SEHI t-AUCB affects KCNQ1
| 1
SEHI t-AUCB activates KCNQ1. 1 / 1
| 1
reach
"In conclusion, the sEHI t-AUCB increases KCNQ1 and KCNH2 mRNA and protein by suppressing miR-133 under ischemic arrhythmia conditions."
29843720
Rubidium(1+) affects KCNQ1
| 1
Rubidium(1+) activates KCNQ1. 1 / 1
| 1
reach
"Rubidium has consistently been reported to increase the open dwell time of BK, KcsA, KCNQ1, ROMK2, and IRK1 channels."
16636204
Rottlerin affects KCNQ1
| 1
Rottlerin activates KCNQ1. 1 / 1
| 1
reach
"Two components of the M. oppositifolius leaf extract, mallotoxin (MTX) and 3-ethyl-2-hydroxy-2-cyclopenten-1-one (CPT1), augmented KCNQ1 current by negative shifting its voltage dependence of activation."
30443601
Pyrithione affects KCNQ1
| 1
Pyrithione activates KCNQ1. 1 / 1
| 1
reach
"Zinc pyrithione (ZnPy) is a potent activator of KCNQ2 and KCNQ3 channels, but also activates KCNQ1 XREF_BIBR, XREF_BIBR."
27261821
Prostaglandin E2-UM affects KCNQ1
| 1
Prostaglandin E2-UM activates KCNQ1. 1 / 1
| 1
reach
"However, even if PGE 2 and TXA 2 stimulate KCNQ1 and KCNE3 channel activity in active UC, this is not accompanied by an overall Cl - secretory response, as net colonic Cl - secretion does not occur in patients with this disease XREF_BIBR, XREF_BIBR."
26718405
Probucol affects KCNQ1
| 1
Probucol inhibits KCNQ1. 1 / 1
| 1
reach
"More specifically, Probucol - known as a cholesterol depleting agent - is able to decrease the coexpressed KCNE1 and KCNQ1 current amplitude XREF_BIBR without decreasing cholesterol levels in CHO-K1 XREF_BIBR."
24681627
Prickle1-a affects KCNQ1
| 1
Prickle1-a phosphorylates KCNQ1. 1 / 1
| 1
reach
"In humans, the sympathetic regulation of the cardiac action potential requires PKA- mediated phosphorylation of the KCNQ1 subunit of the slowly activating delayed rectifier potassium channel I Ks (XREF_FIG and XREF_FIG)."
23043438
Potassium(1+) affects KCNQ1
| 1
Potassium(1+) activates KCNQ1. 1 / 1
| 1
reach
"Mutations in genes encoding the major potassium ion channels mediating this event, KCNQ1 and HERG, therefore account for ~ 90% of cases of inherited long QT syndrome."
26481773
Pimozide affects KCNQ1
| 1
Pimozide inhibits KCNQ1. 1 / 1
| 1
reach
"In contrast, pimozide (10 microM) was a weak inhibitor of KvLQT1 and minK and Kv1.5."
10762666
Phosphatidylinositol affects KCNQ1
| 1
Phosphatidylinositol activates KCNQ1. 1 / 1
| 1
sparser
"Recent mutational analysis indicates that a cluster of basic residues in the proximal C-terminus (K354/K358/R360/K362) is crucial for PI(4,5)P 2 activation of cardiac Kv7.1 channels."
23291709
P15AS affects KCNQ1
| 1
P15AS inhibits KCNQ1. 1 / 1
| 1
reach
"Intriguing examples are the p15AS (p15 antisense transcript), which is expressed in antisense orientation to the cyclin dependent kinase inhibitor p15 and controls its silencing by heterochromatin formation in a DICER dependent manner, and the KCNQ1 antisense transcripts (KCNQ1ot1) which represses KCNQ1 by recruiting the H3K9 histone methyltransferase G9a and the PRC2 complex increasing the level of H3K9me3 and H3K27me3 in cis to its locus."
26617633
P.G272S affects KCNQ1
| 1
P.G272S inhibits KCNQ1. 1 / 1
| 1
reach
"The variants KCNQ1 (p.G272S) and KCNH2 (p.A913V) resulted in gain of function due to faster activation (KCNQ1) and slowed deactivation kinetics (KCNQ1, KCNH2)."
28549997
Okadaic acid affects KCNQ1
| 1
Okadaic acid activates KCNQ1. 1 / 1
| 1
reach
"As we have previously reported, XREF_BIBR dialysis of patch clamped Chinese hamster ovary (CHO) cells co-expressing wild type KCNE1, KCNQ1, and Yotiao with cAMP (0.2 mM) and OA (0.2 muM) increases the activity of KCNE1 and KCNQ1 channels that can be quantified by measuring the amplitude of deactivating current tails (after +100 mV test pulses : -cAMP/OA 72.0 +/- 8.7 pA/pF, n = 10; cAMP/OA 133.7 +/- 10.8 pA/pF, n = 10; p < 0.05) (XREF_FIG)."
19077539
MuM DSA L affects KCNQ1
| 1
MuM DSA L activates KCNQ1. 1 / 1
| 1
reach
"KCNQ1 and KCNE1 expressing oocytes were treated with human recombinant Klotho protein (30 ng/mL) for 24 h. Moreover, oocytes which express both KCNQ1 and KCNE1 and Klotho were treated with 10 muM DSA L (D-saccharic acid-1,4-lactone), a beta-glucuronidase inhibitor."
24457979
MinK-L51H affects KCNQ1
| 1
KCNQ1 binds minK-L51H. 1 / 1
| 1
reach
"Collectively, our data suggest that ER quality control prevents minK-L51H and KvLQT1 complexes from trafficking to the plasma membrane, resulting in decreased I (Ks)."
14761891
MiR190 affects KCNQ1
| 1
MiR190 inhibits KCNQ1. 1 / 1
| 1
reach
"Moreover, KCNQ1 and KCNQ5 are down-regulated by other miRs, namely, miR1/133 and miR190, respectively."
27389411
MiR1/133 affects KCNQ1
| 1
MiR1/133 inhibits KCNQ1. 1 / 1
| 1
reach
"Moreover, KCNQ1 and KCNQ5 are down-regulated by other miRs, namely, miR1/133 and miR190, respectively."
27389411
MiR-1/133 affects KCNQ1
| 1
Modified miR-1/133 decreases the amount of KCNQ1. 1 / 1
| 1
reach
"An overexpression of miR-1/133 abolished KCNE1 and KCNQ1 expression, thus reducing the I KS with enhanced risk of lethal arrhythmias."
29259974
Magnesium atom affects KCNQ1
| 1
Magnesium atom inhibits KCNQ1. 1 / 1
| 1
reach
"External Mg 2+ (10 mM) neither blocked KCNQ1 conductance nor affected channel gating (online supplemental material, available at http://www.jgp.org/cgi/content/full/jgp.200409068/DC1)."
15226366
LncRNA Kcnq1ot1 affects KCNQ1
| 1
LncRNA Kcnq1ot1 decreases the amount of KCNQ1. 1 / 1
| 1
reach
"For example, the lncRNA Kcnq1ot1 represses the transcription of the gene kcnq1, recruiting to its promoter G9a and two members of the polycomb repressive complex 2 (PRC2) -- Ezh2 and Suz12 -- responsible for tri methylation of H3K9 and H3K27 [XREF_BIBR]."
27006627
Lipopolysaccharide affects KCNQ1
| 1
Lipopolysaccharide activates KCNQ1. 1 / 1
| 1
reach
"This LPS induced current exhibited KCNQ1 K+ channel characteristics, i.e. inhibition by quinidine, chromanol293B and low dose of HMR1556 (IC50 < 1 microM) and insensitive to TEA and charybdotoxin."
20332617
Inositol affects KCNQ1
| 1
Inositol binds KCNQ1. 1 / 1
| 1
sparser
"KCNQ1 interaction with sodium-coupled myo-inositol transporters."
28718502
Hydrogen chloride affects KCNQ1
| 1
Hydrogen chloride activates KCNQ1. 1 / 1
| 1
reach
"Both types take part in Cl - secretion in rat colon : Ca 2+ -dependent rSK4 channels (Warth et al., 1999) and cyclic AMP activated KCNQ1 and KCNE3 channels (Schroeder et al., 2000)."
12799067
Hsa-miR-133a-3p affects KCNQ1
1 |
Transcriptionally active hsa-miR-133a-3p decreases the amount of KCNQ1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
17443681
Guanosine monophosphate affects KCNQ1
| 1
Guanosine monophosphate activates KCNQ1. 1 / 1
| 1
reach
"Elevations in the levels of cAMP, cyclic guanosine monophosphate (cGMP), and Ca 2+ activate apical Cl - channels (CFTR and CaCC) and basolateral K + channels (KCNQ1 and KNE3, KCNN4)."
22850599
Glucocorticoid-inducible kinase 1 affects KCNQ1
| 1
Glucocorticoid-inducible kinase 1 activates KCNQ1. 1 / 1
| 1
reach
"We further demonstrate that RAB dependent KCNQ1 and KCNE1 exocytosis is enhanced by the serum- and glucocorticoid inducible kinase 1, and requires phosphorylation and activation of phosphoinositide 3-phosphate 5-kinase and the generation of PI (3,5) P (2)."
17293474
Globin affects KCNQ1
| 1
KCNQ1 binds globin. 1 / 1
| 1
sparser
"Our results suggest that rs231841 on the KCNQ1 gene with positive natural selection is related to Hb A 2 levels in Chinese β-thal carriers, and KCNQ1 is probably associated with the expression of the β-like globin gene cluster."
28747083
Gene hKCNE4 affects KCNQ1
| 1
Gene hKCNE4 inhibits KCNQ1. 1 / 1
| 1
reach
"Novel gene hKCNE4 slows the activation of the KCNQ1 channel."
12670483
Gate affects KCNQ1
| 1
Gate activates KCNQ1. 1 / 1
| 1
reach
"The propensity of KCNQ1 for conversion to leak mode by MiRP1 and MiRP2 poses several questions, three of which we address here : how can a channel with a voltage sensor lose voltage dependence; is the KCNQ1 activation gate uncoupled from S4 in leak channels; and why do MiRP1 and MiRP2 not convert any of their many other potassium channel partners to leak channels?"
17227916
Full-length hKCNE4 affects KCNQ1
| 1
Full-length hKCNE4 inhibits KCNQ1. 1 / 1
| 1
reach
"In contrast, full-length hKCNE4 inhibition of KCNQ1 was limited to 40% at +40 mV vs. 80% inhibition by the shorter form, and augmentation of KCNQ4 activity by hKCNE4 was entirely abolished by the additional segment."
27162025
Flecainide affects KCNQ1
| 1
Flecainide inhibits KCNQ1. 1 / 1
| 1
reach
"Moreover, Flecainide blocks the rapid component of the delayed rectifier potassium current (IKr) (KCNH2 and KCNQ1), prolonging the action potential duration (APD) in ventricular and atrial muscle fibers [82]."
29551391
Fenamic acid affects KCNQ1
| 1
Fenamic acid activates KCNQ1. 1 / 1
| 1
sparser
"For example, Kcnq1 and Slc22a18 are selectively activated by 13.5 and 18.5 dpc, respectively, from the normally silent paternal alleles in embryonic tissues but not in placenta, indicating that in addition to embryo-specific mechanisms, placental-specific mechanisms are layered on the ubiquitously imprinted genes."
21345374
Ethanol affects KCNQ1
| 1
Ethanol activates KCNQ1. 1 / 1
| 1
reach
"XREF_FIG illustrates representative whole-cell currents recorded from KCNQ1 expressing oocytes treated with CHX or EtOH and injected with prKCNE1."
20139709
Estradiol affects KCNQ1
| 1
Estradiol activates KCNQ1. 1 / 1
| 1
reach
"She showed that estradiol inhibits secretion in the colonic epithelia by targeting the KCNQ1 channels via PKC and CREB signaling."
19073201
Dofetilide affects KCNQ1
| 1
Dofetilide inhibits KCNQ1. 1 / 1
| 1
reach
"The I (Kr)-specific blockers, E-4031 and dofetilide, do not inhibit KvLQT1, whereas clofilium, a class III antiarrhythmic agent with the propensity to induce torsades de pointes, substantially inhibits the current."
9108097
Dihydroartemisinin affects KCNQ1
| 1
Dihydroartemisinin activates KCNQ1. 1 / 1
| 1
sparser
"DHA activates Kv7.1 by shifting the G(V) curve in the negative direction along the voltage axis."
27818172
Dexamethasone affects KCNQ1
| 1
Dexamethasone inhibits KCNQ1. 1 / 1
| 1
reach
"The down-regulation of KCNN4 and KCNQ1 channel activities by dexamethasone involves rapid non genomic activation of PKCalpha and PKA signalling pathways, respectively."
31330137
DeltaCaMKII affects KCNQ1
| 1
DeltaCaMKII phosphorylates KCNQ1. 1 / 1
| 1
reach
"20 Therefore, the ability of activated deltaCaMKII to phosphorylate intracellular regions of KCNQ1 was assessed using a peptide array."
29410121
Cyclosporin A affects KCNQ1
| 1
Cyclosporin A activates KCNQ1. 1 / 1
| 1
reach
"Of note, cyclosporine A has been proposed to activate KCNQ1 47, and this immunosuppressive agent also frequently causes GF as a side effect."
29097701
Connexin-40 affects KCNQ1
| 1
Connexin-40 increases the amount of KCNQ1. 1 / 1
| 1
isi
"Expression (mRNA) of KCNQ1 and connexin-40 were increased, but KCNA5 was decreased in the right atrium of rats exposed to chronic ethanol."
31756527
Ciguatoxin CTX1B affects KCNQ1
| 1
Ciguatoxin CTX1B inhibits KCNQ1. 1 / 1
| 1
reach
"Whereas application of 200 nM CTX did not suppress wild-type KCNQ1 channels, half-maximal blockade at equilibrium (K i) for Kv * channels was achieved at 0.93 +/- 0.11 nM CTX."
14527430
Cholesterol affects KCNQ1
| 1
Cholesterol inhibits KCNQ1. 1 / 1
| 1
reach
"In the present study, we investigated the effects of three cholesterol lowering agents (probucol, an enhancer of cholesterol efflux; simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor; and triparanol, a 3beta-hydroxysterol-^ 24-reductase inhibitor) on cholesterol synthesis, the KCNQ1 current (I KCNQ1), and the I (Ks) to clarify the differences in the modes of action of these agents on the I (Ks)."
23424208
Chlorthalidone affects KCNQ1
| 1
Chlorthalidone inhibits KCNQ1. 1 / 1
| 1
reach
"Chlorthalidone inhibits the KvLQT1 potassium current in guinea-pig ventricular myocytes and oocytes from Xenopus laevis."
18037918
Catenin affects KCNQ1
| 1
Catenin inhibits KCNQ1. 1 / 1
| 1
reach
"Louis Richter, Joseph Morris, Irene Oglesby, Eimear Dunne, Dermot Kenny P4 : Beta catenin and TCF4 activation reduces KCNQ1 current in colonic monolayers Ibrahim Mohammed Mahdi Khayyat, Viviana Bustos Salgado, Brian J. Harvey P5 : Size Matters."
| PMC
Carbachol affects KCNQ1
| 1
Carbachol activates KCNQ1. 1 / 1
| 1
reach
"TxA 2 has been shown to increase intracellular Ca 2+ in platelets XREF_BIBR, and thus its stimulatory effect on KCNQ1 and KCNE3 channels in human colonic crypts may also be Ca 2+ -mediated, since carbachol (a Ca 2+ -mediated cholinergic agonist) activated KCNQ1 and KCNE3 channels during its stimulation of Cl - secretion in mouse colon XREF_BIBR."
26718405
Cadmium atom affects KCNQ1
| 1
Cadmium atom decreases the amount of KCNQ1. 1 / 1
| 1
reach
"Failure of voltage to alter block in the latter case suggests that the KCNQ1 mutations alter the pathway taken by Cd 2+, and/or the location of the Cd 2+ binding site, and/or the function of the Cd 2+ -occupied channel.Pore blockers (especially those that are charged) are often affected by ions in the conduction pathway; thus, efflux of internal potassium, rubidium, and cesium alters external Cd 2+ block of channels with MinK-55C and wild-type KCNQ1 expressed in oocytes (Tai and Goldstein, 1998)."
12770875
Butyric acid affects KCNQ1
| 1
Butyric acid inhibits KCNQ1. 1 / 1
| 1
reach
"Thus, it is conceivable that reduced oxidation of butyrate by colonic epithelial cells, as occurs in UC XREF_BIBR, might result in upregulation of KCNQ1 and KCNE3 and/or BK channels in this disease."
26718405
Bepridil affects KCNQ1
| 1
Bepridil inhibits KCNQ1. 1 / 1
| 1
reach
"Similarly, KvLQT1 and IsK is inhibited by bepridil (EC50 = 10.0 microM) and mibefradil (EC50 = 11.8 microM), while being insensitive to nitrendipine, diltiazem, or verapamil."
9765513
Benzodiazepine R-L3 affects KCNQ1
| 1
Benzodiazepine R-L3 inhibits KCNQ1. 1 / 1
| 1
reach
"In addition, benzodiazepine R-L3 increases the magnitude and slows the gating of KCNQ1 channels, but has no effect on KCNQ1 / minK channels [68]."
12623297
Benzodiazepine L-364,373 affects KCNQ1
| 1
Benzodiazepine L-364,373 activates KCNQ1. 1 / 1
| 1
reach
"The benzodiazepine L-364,373, which activates KCNQ1 even when expressed alone either in Xenopus oocytes [18] or in COS cells (not shown), is unable to activate the KCNQ2 channel."
9827540
Associated mutations affects KCNQ1
| 1
Associated mutations inhibits KCNQ1. 1 / 1
| 1
reach
"LQT1 associated mutations increase KCNQ1 proteasomal degradation independently of Derlin-1."
19114714
Arsenic atom affects KCNQ1
| 1
Arsenic atom decreases the amount of KCNQ1. 1 / 1
| 1
reach
"Expression of the ion-channel genes CACNA1, KCNH2, KCNQ1 and KCNE1 were down-regulated by 1-muM arsenic."
21776218
Amiloride affects KCNQ1
| 1
Amiloride activates KCNQ1. 1 / 1
| 1
reach
"In conclusion, amiloride induces KCNQ1 splicing changes through affecting expression of splicing factors, and the effects show transmural differences."
23608591
Alr2 affects KCNQ1
| 1
Alr2 decreases the amount of KCNQ1. 1 / 1
| 1
reach
"Insights acquired here show for the first time that the blockade of the ALR2 with BF-5m causes changes of the expression of H9c2 KCNQ1 and KCNE1 potassium channels subunits at the plasma membrane level and not at the level of the mitochondria after high glucose exposure."
29707106
Alpha-KTx ImKTx104 affects KCNQ1
| 1
Alpha-KTx ImKTx104 inhibits KCNQ1. 1 / 1
| 1
reach
"In addition to the known pharmacological effects of acidic KTxs on Kv1.x and SKCa channels XREF_BIBR, XREF_BIBR, our electrophysiological studies demonstrated for the first time that the alpha-KTx ImKTx104 blocked the KCNQ1 channel with a K d of 11.69 microM."
22511981
Adenosine 5'-monophosphate affects KCNQ1
| 1
Adenosine 5'-monophosphate inhibits KCNQ1. 1 / 1
| 1
reach
"AMP activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells."
20861072
Adenosine affects KCNQ1
| 1
Adenosine inhibits KCNQ1. 1 / 1
| 1
reach
"Adenosine (0.1 mm) also inhibited the KCNQ1 currents by about 56%."
22805606
Acetylcholine affects KCNQ1
| 1
Acetylcholine inhibits KCNQ1. 1 / 1
| 1
reach
"This study demonstrated that ACh inhibition of KCNQ1 and KCNE1 currents in injected Xenopus laevis oocytes was lower in activated-PKA conditions and higher in inhibited-PKA conditions as compared to control."
22787448
Zinc affects KCNQ1
| 1
Zinc activates KCNQ1. 1 / 1
| 1
reach
"Zinc pyrithione (ZnPy) is a potent activator of KCNQ2 and KCNQ3 channels, but also activates KCNQ1 XREF_BIBR, XREF_BIBR."
27261821
Wave affects KCNQ1
| 1
KCNQ1 binds Wave. 1 / 1
| 1
sparser
"LQT1 is associated with a broad-based T wave, LQT2 with a low amplitude notched or biphasic T wave, and LQT3 with a long isoelectric segment followed by a narrow-based T wave."
21382904
VCL affects KCNQ1
| 1
VCL activates KCNQ1. 1 / 1
| 1
reach
"In contrast, KCNE5 shifts the voltage dependence of KCNQ1 activation by ~ +140 mV, and in this way renders it effectively nonfunctional at physiological membrane potentials (Angelo et al., 2002)."
27484720
USP2-45/-69 affects KCNQ1
| 1
KCNQ1 binds USP2-45/-69. 1 / 1
| 1
reach
"Our results demonstrated that both USP2-45 and -69 isoforms coimmunoprecipitated with KCNQ1, independently of the presence of Nedd4-2, indicating a direct interaction between KCNQ1 and USP2-45/-69."
22024150
UCL-2077 affects KCNQ1
| 1
UCL-2077 inhibits KCNQ1. 1 / 1
| 1
reach
"We show that the KCNQ1 antagonists UCL-2077 and JNJ-303 were effective at blocking the mAHP and sAHP, and this resulted in rescue of spike frequency in shTCF4 cells."
26971948
UBE2K affects KCNQ1
| 1
UBE2K decreases the amount of KCNQ1. 1 / 1
| 1
reach
"As it has been recently shown that the ubiquitin protein ligase Nedd4-2 inhibits KCNQ1 plasma membrane expression and that AMPK regulates epithelial Na (+) channels via Nedd4-2, we examined the role of Nedd4-2 in the AMPK dependent regulation of KCNQ1."
20861072
Toxins ImKTx104 affects KCNQ1
| 1
Toxins ImKTx104 inhibits KCNQ1. 1 / 1
| 1
reach
"Toxins ImKTx104 and HeTx204 effectively blocked the KCNQ1 channel at 10 microM concentration, while LmKTx2 and HeTx203 only weakly inhibited the KCNQ1 channel at the same concentration, and 10 microM StKTx23 did not inhibit KCNQ1 channels."
22511981
Tanshinone IIA affects KCNQ1
| 1
Tanshinone IIA activates KCNQ1. 1 / 1
| 1
reach
"Tanshinone IIA : a new activator of human cardiac KCNQ1 and KCNE1 (I (Ks)) potassium channels."
18573250
Tan affects KCNQ1
| 1
Tan activates KCNQ1. 1 / 1
| 1
reach
"On gene level, Sun et al. [XREF_BIBR] indicated that Tan IIA could activate human cardiac KCNQ1 and KCNE1 potassium channels (I Ks) in HEK 293 cell directly and specifically through affecting the channels ' kinetics, which would be a promising therapeutic medicine in arrhythmia."
22454677
TNF affects KCNQ1
| 1
TNF activates KCNQ1. 1 / 1
| 1
reach
"We now show that TNF-alpha enhances KvLQT1 and K (ATP) currents, while their inhibition abolishes TNF-alpha-induced repair stimulation."
21908587
TBX5 affects KCNQ1
| 1
TBX5 activates KCNQ1. 1 / 1
| 1
reach
"We speculated that Tbx5 and its binding site could be important for activation of Kcnq1 and could help determine the domain-wide conformation of the region in the heart."
25539921
TAC1 affects KCNQ1
| 1
TAC1 inhibits KCNQ1. 1 / 1
| 1
reach
"Thus, we observed that PPT inhibited IK s and KCNQ1 alone K + channels currents in both concentration- and voltage dependent manners, but the PPT blockade of the IK s current had an IC 50 value of 5.18 +/-0.13 muM, which was 2-fold less than that of KCNQ1 alone K + current."
24198658
T58V-MinK affects KCNQ1
| 1
KCNQ1 binds T58V-MinK. 1 / 1
| 1
reach
"Furthermore, swapping of this central residue of the " activation triplet " within the transmembrane domain between MinK and MiRP2 bestows the activation properties of either subunit on complexes formed with KCNQ1; T58V-MinK and KCNQ1 complexes exhibit a degree of constitutive activation, whereas V72T-MiRP2-KCNQ1 complexes produce slowly activating currents."
17227916
T2A3 affects KCNQ1
| 1
T2A3 inhibits KCNQ1. 1 / 1
| 1
reach
"34 Interestingly, T2A3 has also been shown to inhibit KCNQ1 as well as TMEM16A in other MLPCN based bioassays (pubchem bioassays 588353 and 588511, respectively)."
27805811
Src-family kinases affects KCNQ1
| 1
Src-family kinases activates KCNQ1. 1 / 1
| 1
reach
"Our results are supported by the previous report in which KCNQ1 channel expressed in CHO cells is not modulated by Src family kinases [32]."
20085748
SjAPI-2 affects KCNQ1
| 1
SjAPI-2 inhibits KCNQ1. 1 / 1
| 1
reach
"Concentration dependent studies showed that SjAPI-2 inhibited the KCNQ1 potassium channel with an IC50 of 771.5 +/-169.9 nM."
26014142
SRC affects KCNQ1
| 1
SRC activates KCNQ1. 1 / 1
| 1
reach
"Our results are supported by the previous report in which KCNQ1 channel expressed in CHO cells is not modulated by Src family kinases [32]."
20085748
SP1 affects KCNQ1
| 1
SP1 activates KCNQ1. 1 / 1
| 1
reach
"It has been reported that the transcription factor Sp1 modulates the activities of the KCNQ1 (which encodes KvLQT1) and KCNH2 (which encodes HERG1) promoters, suggesting that the differential expression of Sp1 (RV> LV) may account for the interventricular gradients of KvLQT1 and HERG1 protein expression [XREF_BIBR, XREF_BIBR]."
26391345
SLC5A5 affects KCNQ1
| 1
SLC5A5 binds KCNQ1. 1 / 1
| 1
sparser
"Regarding the mechanism of KCNQ1-NIS interaction, we do not yet have confirmation of a physical interaction, although this is suspected."
27098917
SIL1 affects KCNQ1
| 1
SIL1 binds KCNQ1. 1 / 1
| 1
sparser
"In the group of MSS tumours, low expression of KCNQ1 was associated with poor DFS in both stage II colon cancer patients (HR 3.82; 95% CI 2.04–7.14; P <0.0001; xref ) and stage III colon cancer patients (HR 2.93; 95% CI 1.70–5.02; P <0.0001; xref )."
27855440
SGMS1 affects KCNQ1
| 1
SGMS1 activates KCNQ1. 1 / 1
| 1
reach
"These results suggest that SMS1 positively regulates KCNQ1 and KCNE1 channel density in a protein kinase D dependent manner."
27194473
SGK3 affects KCNQ1
| 1
SGK3 activates KCNQ1. 1 / 1
| 1
reach
"SGK3 has previously been shown to up-regulate KCNQ1 and KCNE1 [32], the other key K + channel involved in cardiac repolarization."
21463633
SGK1-3 affects KCNQ1
| 1
SGK1-3 activates KCNQ1. 1 / 1
| 1
reach
"Moreover, SGK1-3 stimulate the KCNE1 and KCNQ1 channel."
23227301
SCARB2 affects KCNQ1
| 1
SCARB2 decreases the amount of KCNQ1. 1 / 1
| 1
reach
"Although LIMP2 is normally expressed in all cells of the stria vascularis, in the organ of Corti and cochlear neurons, the lack of LIMP2 preferentially caused a loss of KCNQ1 and KCNE1 and megalin, and structural changes were only seen months later, indicating that these proteins are highly sensitive to disturbances in the lysosomal pathway."
16901941
S18 affects KCNQ1
| 1
S18 activates KCNQ1. 1 / 1
| 1
reach
"S17 and S18) but modulate KCNQ1 channel function very differently."
27626070
Radix astragali affects KCNQ1
| 1
Radix astragali increases the amount of KCNQ1. 1 / 1
| 1
reach
"Radix astragali significantly reduced the ABR deficits and the SV damage, and decreased the shifts of the expression of cx26 and KCNQ1 in the SV."
24858698
RAB5A affects KCNQ1
| 1
RAB5A inhibits KCNQ1. 1 / 1
| 1
reach
"Fluvastatin inhibition of Rab5 has been shown to mediate cPKC dependent trafficking regulation of the cardiac delayed rectifier KCNQ1 and KCNE1 channels."
31780674
QT c affects KCNQ1
| 1
QT c activates KCNQ1. 1 / 1
| 1
reach
"However, a recent study showed that hypergastrinemia, a marker of parietal cell dysfunction, correlated well with QT c prolongation in KCNQ1 linked Jervell and Lange-Nielsen Syndrome 32."
24403551
Purinergic_receptors affects KCNQ1
| 1
Purinergic_receptors inhibits KCNQ1. 1 / 1
| 1
reach
"P2U purinergic receptor inhibits apical IsK and KvLQT1 channel via protein kinase C in vestibular dark cells."
9435509
Pitx2c affects KCNQ1
| 1
Pitx2c activates KCNQ1. 1 / 1
| 1
reach
"Luciferase assays demonstrated that Pitx2c increased transcriptional activity of KCNQ1 and KCNE1 genes."
26714926
Phe-Glu affects KCNQ1
| 1
Phe-Glu increases the amount of KCNQ1. 1 / 1
| 1
reach
"Effect of Fe 3 O 4 -magnetic nanoparticles on acute exercise enhanced KCNQ 1 expression in mouse cardiac muscle."
20309397
PRKCA affects KCNQ1
| 1
PRKCA inhibits KCNQ1. 1 / 1
| 1
reach
"The molecular mechanism by which berberine induced activation of PKCalpha and p38 MAPK inhibits basolateral KCNQ1 channels in T84 is an important goal of future studies."
21747769
PRKAR2A affects KCNQ1
1 |
KCNQ1 binds PRKAR2A. 1 / 1
1 |
biogrid
No evidence text available
11799244
PPARG affects KCNQ1
| 1
KCNQ1 binds PPARG. 1 / 1
| 1
sparser
"Variants ADRA2A rs553668, IGF2BP2 rs4402960, KCNQ1 rs2237892, and PPARG rs1801282 were previously associated with T2D and identified by GWAS in European and/or Asian populations."
29800730
PITX2c affects KCNQ1
| 1
Modified PITX2c inhibits KCNQ1. 1 / 1
| 1
reach
"As shown in XREF_FIG, knockdown of the PITX2c expression by siRNA significantly increased expression of NKX2.5 by 3.10-fold, TBX5 by 2.32-fold, KCNQ1 by 1.55-fold, and SCN1B by 1.27-fold."
26267381
PHLDA2 affects KCNQ1
| 1
PHLDA2 activates KCNQ1. 1 / 1
| 1
reach
"Compared to controls, we observed that Nup107 and Nup62 depletion increased paternal Osbpl5 transcripts by 13,472-13,662 copies, Nup107 depletion increased Phlda2 transcripts by 430 copies, Nup107, Nup62, and Nup153 depletion increased paternal transcripts of Slc22a18 by 29,547-32,214, Cdkn1c by 10,882-13,153, and Kcnq1 by 728-805 copies, and Nup153 depletion increased Cd81 transcripts by 13,033 copies."
30022050
PEG10 affects KCNQ1
| 1
PEG10 binds KCNQ1. 1 / 1
| 1
reach
"In contrast, the stronger associations between both Peg10 and Kcnq1 and E12.5 placental phenotypes were not occluded by confounding epistatic effects."
26241757
PDC affects KCNQ1
| 1
PDC activates KCNQ1. 1 / 1
| 1
reach
"Because Ca 2+ / CaM is required for desensitization of TRPV1 (Numazaki et al., 2003), we suggest that PDC contributes to recovery from desensitization.In addition to TRP channels, KCNQ1, and Ca v 1.2, many additional classes of ion channels and ion transporters appear to bind PIs and CaM (reviewed in Saimi and Kung [2002], Suh and Hille [2005], and Halling et al. [2006])."
17317623
PC affects KCNQ1
| 1
PC decreases the amount of KCNQ1. 1 / 1
| 1
reach
"Moreover, PC and MC (1 mM) decreased KCNQ1 protein expression (relative density : 0.58 +/- 0.08 and 0.16 +/- 0.05; P <.01)."
26854997
NUP107 affects KCNQ1
| 1
NUP107 activates KCNQ1. 1 / 1
| 1
reach
"Compared to controls, we observed that Nup107 and Nup62 depletion increased paternal Osbpl5 transcripts by 13,472-13,662 copies, Nup107 depletion increased Phlda2 transcripts by 430 copies, Nup107, Nup62, and Nup153 depletion increased paternal transcripts of Slc22a18 by 29,547-32,214, Cdkn1c by 10,882-13,153, and Kcnq1 by 728-805 copies, and Nup153 depletion increased Cd81 transcripts by 13,033 copies."
30022050
NPR1 affects KCNQ1
| 1
NPR1 activates KCNQ1. 1 / 1
| 1
reach
"Collectively, these results suggest that NPR-A promotes gastric cancer development in part by regulating KCNQ1."
25419351
MicroRNA-1/133 affects KCNQ1
| 1
MicroRNA-1/133 activates KCNQ1. 1 / 1
| 1
reach
"MicroRNA-1/133 targeted dysfunction of potassium channels KCNE1 and KCNQ1 in human cardiac progenitor cells with simulated hyperglycemia."
23157812
MiRP2 affects KCNQ1
| 1
MiRP2 activates KCNQ1. 1 / 1
| 1
reach
"While the expression of MiRP2 in heart tissue suggests a role in cardiac excitability, it is not yet known whether MiRP2 modulates hERG, KCNQ1 or any other channels in vivo in mammalian heart."
19219384
MiRP1 Chimera affects KCNQ1
| 1
MiRP1 Chimera activates KCNQ1. 1 / 1
| 1
reach
"A MinK and MiRP1 Chimera Modulates KvLQT1."
10962015
MTNR1B affects KCNQ1
| 1
KCNQ1 binds MTNR1B. 1 / 1
| 1
sparser
"Associations of MTNR1B [ xref ] and KCNQ1 [ xref ] with GDM were also identified in Korean studies."
28049284
MT2A affects KCNQ1
| 1
MT2A inhibits KCNQ1. 1 / 1
| 1
reach
"Concentration dependent experiments showed that MT2 inhibited the KCNQ1 and KCNE1 channel with an IC50 value of 4.6 +/-1.9 muM."
26188173
MT2-2 peptide affects KCNQ1
| 1
MT2-2 peptide inhibits KCNQ1. 1 / 1
| 1
reach
"With MT2 as a new template, we further designed a more potent MT2-2 peptide, which selectively inhibited the KCNQ1 and KCNE1 channel with an IC50 of 1.51 +/-0.62 muM."
26188173
MSI affects KCNQ1
| 1
KCNQ1 binds MSI. 1 / 1
| 1
sparser
"In the group of MSI tumours, low expression of KCNQ1 was not significantly associated with DFS in stage II colon cancer patients (HR 3.37; 95% CI 0.38–30.17; P =0.278; xref ), but was associated with poor DFS in stage III colon cancer patients (HR 5.06; 95% CI 1.07–23.89; P =0.041; xref )."
27855440
MP affects KCNQ1
| 1
MP increases the amount of KCNQ1. 1 / 1
| 1
reach
"To determine if the Kcnq1ot1 MP sequence per se contributed to the RNA levels of Kcnq1, we performed RT-qPCR for Kcnq1 from 10.5 dpc and neonatal heart and neonatal brain in Kcnq1ot1 +/PO mice."
25539921
MESET affects KCNQ1
| 1
MESET inhibits KCNQ1. 1 / 1
| 1
reach
"MESET decreases the KCNQ1 */KCNE1-E43C current amplitude because of a positive shift in V 0.5 (XREF_FIG), whereas it increases the KCNQ1 */KCNE2-Y48C current amplitude because of a negative shift in V 0.5 (XREF_FIG)."
23183700
MAP affects KCNQ1
| 1
KCNQ1 binds MAP. 1 / 1
| 1
sparser
"The identification of a secondary structure within the KCNE1 C-terminal domain provides a structural scaffold to map protein–protein interactions with the pore-forming KCNQ1 subunit as well as the cytoplasmic regulatory proteins anchored to KCNQ1–KCNE complexes."
17130521
Lys-Ser affects KCNQ1
| 1
Lys-Ser activates KCNQ1. 1 / 1
| 1
reach
"Although KCNE1 is necessary to reproduce the functional properties of the native I (Ks) channel, the mechanism (s) through which KCNE1 modulates KCNQ1 is unknown."
21149716
LmKTx2 affects KCNQ1
| 1
LmKTx2 inhibits KCNQ1. 1 / 1
| 1
reach
"Toxins ImKTx104 and HeTx204 effectively blocked the KCNQ1 channel at 10 microM concentration, while LmKTx2 and HeTx203 only weakly inhibited the KCNQ1 channel at the same concentration, and 10 microM StKTx23 did not inhibit KCNQ1 channels."
22511981
LTD affects KCNQ1
| 1
LTD activates KCNQ1. 1 / 1
| 1
reach
"By contrast, the proinflammatory mediators IL-1beta (which originates from helper CD4 T lymphocytes, monocytes, macrophages and endothelial cells), and LTD 4 (another eicosanoid inflammatory mediator), both of which stimulate Cl - secretion in non inflamed mammalian colon XREF_BIBR, XREF_BIBR, failed to stimulate KCNQ1 and KCNE3 channel activity in control crypts, due to either the acute nature of our experiments, or the non involvement of KCNQ1 and KCNE3 channels in the Cl - -secretory effects of IL-1beta and LTD 4."
26718405
LQT2 affects KCNQ1
| 1
LQT2 activates KCNQ1. 1 / 1
| 1
reach
"LQT1 and LQT2 are caused due to mutations in the potassium channel genes, KCNQ1 (OMIM # 607542) and KCNH2 (OMIM # 152427) respectively, while LQT3 is caused by mutations in a sodium channel gene, SCN5A (OMIM # 600163) XREF_BIBR."
27485560
LQT affects KCNQ1
| 1
KCNQ1 binds LQT. 1 / 1
| 1
reach
"Hence, a consistent association between KCNQ1 and LQT and epilepsy remains to be demonstrated.Here we report a family showing the association of epilepsy concomitant with LQTS."
25645639
Kv4.3 affects KCNQ1
| 1
Kv4.3 inhibits KCNQ1. 1 / 1
| 1
reach
"Insulin substitution fully prevented the diabetes induced changes in I (Ks), KvLQT1 and MinK, however, the changes in I (to), Kv4.3, and Kv1.4 were only partially diminished by insulin."
17182020
Kv1.4 affects KCNQ1
| 1
Kv1.4 inhibits KCNQ1. 1 / 1
| 1
reach
"Insulin substitution fully prevented the diabetes induced changes in I (Ks), KvLQT1 and MinK, however, the changes in I (to), Kv4.3, and Kv1.4 were only partially diminished by insulin."
17182020
Kv1.2 affects KCNQ1
| 1
Kv1.2 activates KCNQ1. 1 / 1
| 1
reach
"In addition to allowing for more sophisticated predictions for Kv channel activation, these crystal structures of Kv1.2 have enabled the generation of open- and closed-state models of KCNQ1, onto which many disease causing mutations have been mapped and KCNE1 interaction modeled."
20421371
KNCE1 affects KCNQ1
| 1
KCNQ1 binds KNCE1. 1 / 1
| 1
reach
"Based on the functional data, we suggest that the interaction between KNCE1 and KCNQ1 may be reversible and transient in a " Kiss & Go " manner, supporting a physiological role for KCNE1 as a dynamic regulatory molecule."
17845799
KMT2A affects KCNQ1
| 1
KMT2A inhibits KCNQ1. 1 / 1
| 1
reach
"Our experimental data revealed that replacement of P320 by two structurally different amino acids (histidine, alanine) prevented KCNQ1 channel function."
19540844
KLF14 affects KCNQ1
| 1
KCNQ1 binds KLF14. 1 / 1
| 1
sparser
"The aim of this investigation was to analyze the association of KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 polymorphisms with T2DM in Han Chinese people in Henan province, China."
26927145
KCNQ1s affects KCNQ1
| 1
KCNQ1 binds KCNQ1s. 1 / 1
| 1
sparser
"All three mutant KCNQ1s assembled with wt KCNQ1 as determined by fluorescence resonance energy transfer (FRET)."
25344363
KCNQ1ot1 affects KCNQ1
| 1
KCNQ1ot1 inhibits KCNQ1. 1 / 1
| 1
reach
"Intriguing examples are the p15AS (p15 antisense transcript), which is expressed in antisense orientation to the cyclin dependent kinase inhibitor p15 and controls its silencing by heterochromatin formation in a DICER dependent manner, and the KCNQ1 antisense transcripts (KCNQ1ot1) which represses KCNQ1 by recruiting the H3K9 histone methyltransferase G9a and the PRC2 complex increasing the level of H3K9me3 and H3K27me3 in cis to its locus."
26617633
KCNQ1 affects yA
| 1
KCNQ1 binds yA. 1 / 1
| 1
sparser
"5 Coimmunoprecipitations of the KCNQ1 PY motif mutant (KCNQ1-YA) revealed that USP2-45 and -69 can also bind to KCNQ1-YA, indicating that this interaction is independent of the PY motif ( Figure 3 B)."
22024150
KCNQ1 affects wave
| 1
KCNQ1-V241F activates wave. 1 / 1
| 1
reach
"The short APD in the V241F KCNQ1 mutation causes a short wavelength and persistent spiral wave of limited size in the 2D and 3D tissue models."
25230101
KCNQ1 affects ubiC
| 1
KCNQ1 inhibits ubiC. 1 / 1
| 1
reach
"Effects of KCNQ1 channel blocker, 293B, on the acetylcholine induced Cl- secretion of rat pancreatic acini."
15097862
KCNQ1 affects triglyceride
| 1
Triglyceride binds KCNQ1. 1 / 1
| 1
reach
"Similar to this, data from a Mexican population suggested significant associations between KCNQ1 and TG and HDL-C [XREF_BIBR]."
32016123
KCNQ1 affects transport
| 1
KCNQ1 activates transport. 1 / 1
| 1
reach
"How KCNQ1 K + channel contributes to epithelial transport in distinct segments of renal tubules remains to be determined."
20353914
KCNQ1 affects tolbutamide
| 1
KCNQ1 activates tolbutamide. 1 / 1
| 1
reach
"The KCNQ1 protein is expressed in insulin secreting cultured cells, and the KCNQ1 blocker inhibits tolbutamide stimulated insulin secretion, which suggests involvement of KCNQ1 in insulin secretion [XREF_BIBR]."
25944304
KCNQ1 affects this family
| 1
KCNQ1 activates this family. 1 / 1
| 1
reach
"The mutation was present in all affected family members but absent in normal control individuals, providing evidence that the mutated KVLQT1 gene product indeed caused LQTS in this family."
9272155
KCNQ1 affects tetramethylsilane
| 1
Tetramethylsilane binds KCNQ1. 1 / 1
| 1
reach
"Since there are no cysteine residues in the extracellular domain of KCNE1, it has been proposed that TMS interacts with its partner protein KCNQ1."
11944086
KCNQ1 affects sqt-3
| 1
KCNQ1 activates sqt-3. 1 / 1
| 1
reach
"SQTS has been associated with the gain-of-function mutations in 3 distinct potassium channels, KCNH2, KCNQ1 and KCNJ2, which cause SQT1, SQT2 and SQT3, respectively [111-114]."
30027834
KCNQ1 affects spn-A
| 1
KCNQ1 binds spn-A. 1 / 1
| 1
sparser
"The CAGA haplotype more frequent among BWS patients was associated with loss of methylation of an exon 10 DMR (KvDMR1) in the maternally imprinted KCNQ1 gene ( xref )."
20639793
KCNQ1 affects sodium(1+)
| 1
Sodium(1+) binds KCNQ1. 1 / 1
| 1
reach
"KCNQ1 interaction with sodium coupled myo-inositol transporters."
28718502
KCNQ1 affects sodium atom
| 1
Modified KCNQ1 increases the amount of sodium atom. 1 / 1
| 1
reach
"7 KCNE1 and KCNQ1 K + channel have been localized to the brush border of the mid to late proximal tubule in mouse, where they maintain the proximal tubule brush border membrane potential, and the loss of KCNQ1 and KCNE1 lead to urinary loss of Na + and glucose."
20353914
KCNQ1 affects sevoflurane
| 1
KCNQ1 inhibits sevoflurane. 1 / 1
| 1
reach
"These results suggest that the inhibition of KCNQ1 underlies sevoflurane induced decrease in airway secretion."
17567648
KCNQ1 affects rps9
| 1
KCNQ1 activates rps9. 1 / 1
| 1
reach
"Further deletion of the human KCNQ1 region diminished the shift of V 1/2 by KCNE1."
22042987
KCNQ1 affects potassium iodide
| 1
KCNQ1-V241F activates potassium iodide. 1 / 1
| 1
reach
"(ii) The V241F KCNQ1 mutation sustained re-entry, produce more persistent wavelets in a limited size of tissue, and led to more frequent atrial excitation in the 2D and 3D model.According to Ki et al. (2013), the V241F KCNQ1 mutation induces an increment of I Ks."
25230101
KCNQ1 affects phenol
| 1
KCNQ1 activates phenol. 1 / 1
| 1
reach
"In addition, TCF7L2 and KCNQ1 increased the risk of both IFH and IPH."
23990951
KCNQ1 affects minK-L51H
| 1
KCNQ1 binds minK-L51H. 1 / 1
| 1
reach
"Collectively, our data suggest that ER quality control prevents minK-L51H and KvLQT1 complexes from trafficking to the plasma membrane, resulting in decreased I (Ks)."
14761891
KCNQ1 affects metabolic process
| 1
KCNQ1 activates metabolic process. 1 / 1
| 1
reach
"The present study explored the influence of KCNQ1 on insulin induced cellular K+ uptake and glucose metabolism."
19369585
KCNQ1 affects long-QT syndrome type 1
| 1
KCNQ1 activates long-QT syndrome type 1. 1 / 1
| 1
reach
"The nonsense mutations R518X KCNQ1 and Q530X-KCNQ1 cause LQT1 (long-QT syndrome type 1) and result in a complete loss of I (Ks) channel function."
22309168
KCNQ1 affects long QT syndromes
| 1
KCNQ1 activates long QT syndromes. 1 / 1
| 1
reach
"We next analyzed mouse lines engineered to carry the orthologous point mutations in Kcnq1 that underlie two human long QT syndromes (XREF_FIG, XREF_SUPPLEMENTARY)."
20368164
KCNQ1 affects long QT syndrome
| 1
KCNQ1 activates long QT syndrome. 1 / 1
| 1
reach
"Potassium channels comprised of KCNQ1 and KCNE1 subunits are responsible for one of the primary cardiac repolarizing currents, the slow delayed rectifier current (I Ks) 17, and mutations in KCNQ1 are known to cause the long QT syndrome XREF_BIBR, XREF_BIBR (LQT1, MIM : 192500) and the rare short QT syndrome XREF_BIBR, XREF_BIBR (MIM : 609621)."
29097701
KCNQ1 affects leucine, and yotiao
| 1
KCNQ1 binds leucine and yotiao. 1 / 1
| 1
reach
"121 These authors elegantly demonstrated that yotiao binds to the human KCNQ1 by a leucine zipper motif, which is disrupted by an LQTS mutation (hKCNQ1-G589D)."
26044251
KCNQ1 affects incretin
| 1
KCNQ1 activates incretin. 1 / 1
| 1
reach
"Therefore, we can not rule out that genetic variation in KCNQ1 may, in addition to its effects on glucose stimulated incretin secretion, also alter GLP-1-induced insulin secretion."
19366866
KCNQ1 affects immune response
| 1
KCNQ1 inhibits immune response. 1 / 1
| 1
reach
"In addition, two risk genes, RFX3 and KCNQ1, which might impair immune response and lead to functional deficiency of beta cell were recently discovered to influence hyperuiceamia and gout in Han Chinese."
27103454
KCNQ1 affects hook
| 1
KCNQ1 inhibits hook. 1 / 1
| 1
reach
"Co-expression of KCNQ1 and KCNE1 results in slowed deactivation kinetics, as well as the removal of the inactivation " hook " on the tail current."
19340287
KCNQ1 affects hereditary long QT syndromes
| 1
Mutated KCNQ1 activates hereditary long QT syndromes. 1 / 1
| 1
reach
"The mutations of KCNQ1 have been known to cause hereditary long QT syndromes, which are characterized by the prolongation of QT intervals on the electrocardiogram; in some instances, these syndromes cause sudden cardiac death in the young through the loss of function of the potassium channel in the heart."
20056949
KCNQ1 affects hereditary long QT syndrome
| 1
KCNQ1 activates hereditary long QT syndrome. 1 / 1
| 1
reach
"Mutations in KCNQ1 underlie the most common type of hereditary long QT syndrome (LQTS)."
18266681
KCNQ1 affects hKCNE4
| 1
KCNQ1 binds hKCNE4. 1 / 1
| 1
reach
"In order to determine if hKCNE4 can interact with HERG and KCNQ1, similar to other KCNE subunits we coexpressed hKCNE1 with wild type (WT) KCNQ1 and with HERG in Xenopus oocytes and CHO cells.Cotransfection of hKCNE4 with WT-HERG did not modify the properties of WT-HERG channel mediated currents."
12670483
KCNQ1 affects globin
| 1
KCNQ1 binds globin. 1 / 1
| 1
sparser
"Our results suggest that rs231841 on the KCNQ1 gene with positive natural selection is related to Hb A 2 levels in Chinese β-thal carriers, and KCNQ1 is probably associated with the expression of the β-like globin gene cluster."
28747083
KCNQ1 affects gintonin
| 1
KCNQ1 inhibits gintonin. 1 / 1
| 1
reach
"Mutations in the KCNQ1 [Ca (2+)] i/CaM binding IQ motif sites (S373P, W392R, or R539W) blocked the action of gintonin on I (Ks) channel."
25234465
KCNQ1 affects gate
| 1
KCNQ1 activates gate. 1 / 1
| 1
reach
"The propensity of KCNQ1 for conversion to leak mode by MiRP1 and MiRP2 poses several questions, three of which we address here : how can a channel with a voltage sensor lose voltage dependence; is the KCNQ1 activation gate uncoupled from S4 in leak channels; and why do MiRP1 and MiRP2 not convert any of their many other potassium channel partners to leak channels?"
17227916
KCNQ1 affects estrogen
| 1
KCNQ1-Q244R activates estrogen. 1 / 1
| 1
reach
"XREF_FIG shows that the KCNQ1 Gln244Arg mutation negates the inhibitory effect of estrogen on KCNQ1-KCNE3 currents."
27626070
KCNQ1 affects ead, and t
| 1
KCNQ1 binds t and ead. 1 / 1
| 1
sparser
"These results strongly suggest that I to is responsible for APD gradient and RV-specific EAD formation in LQT1 rabbits."
29769222
KCNQ1 affects disease phenotype
| 1
KCNQ1 inhibits disease phenotype. 1 / 1
| 1
reach
"18 Importantly, this finding was validated in a replication cohort consisting of 336 LQT1 patients from South African KCNQ1-A341V and Finnish KCNQ1-G589D founder populations, suggesting that at the very least the KCNQ1 rs2074238 SNP attenuates the LQT1 disease phenotype in multiple genetic backgrounds."
23963159
KCNQ1 affects ctcA
| 1
KCNQ1 binds ctcA. 1 / 1
| 1
reach
"To find a possible physiological function of the constitutively open KCNQ1 and CHIF complex, the precise localization of KCNQ1 and CHIF in distal colon and kidney from control and salt depleted rats was determined by confocal microscopy."
16476578
KCNQ1 affects chromanol
| 1
Chromanol binds KCNQ1. 1 / 1
| 1
sparser
"For example, NS1643 was discovered to bind to KCNQ1 and to enhance the channel conductance xref , whereas chromanol 293B could interact with KCNQ1 and inhibit the channel xref ."
26307551
KCNQ1 affects chromane
| 1
KCNQ1 activates chromane. 1 / 1
| 1
reach
"We explored the pharmacological properties of trans-6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dime thyl- chromane (293B), a chromanol compound, on the K+ current produced by direct intranuclear injection of KvLQT1 and IsK cDNA plasmids in COS-7 cells."
9396783
KCNQ1 affects channel subfamily N member 4
| 1
KCNQ1 activates channel subfamily N member 4. 1 / 1
| 1
reach
"On the basolateral membrane, Na-K-2Cl cotransporter 1 (NKCC1) contributes to the uptake of Cl -, and the Na + / K + ATPase and K + channels, such as potassium voltage gated channel subfamily Q member 1 (KCNQ1) and potassium calcium activated channel subfamily N member 4 (KCNN4), support the function of NKCC1 by producing an electrochemical gradient across the luminal membrane XREF_BIBR."
27827428
KCNQ1 affects cell migration
| 1
KCNQ1 activates cell migration. 1 / 1
| 1
reach
"In AE there is evidence that K + channels may be involved in alveolar epithelial cell repair processes [XREF_BIBR], since the inhibition of K ATP and KvLQT1 K + channels reduces wound healing, cell migration, and proliferation in a model of mechanical injury of primary cultured rat ATII cells [XREF_BIBR]."
22131798
KCNQ1 affects cause type 1 long-QT syndrome
| 1
Mutated KCNQ1 inhibits cause type 1 long-QT syndrome. 1 / 1
| 1
reach
"KCNQ1 mutations that disrupt this complex cause type 1 long-QT syndrome (LQT1), one of the potentially lethal heritable arrhythmia syndromes."
21978991
KCNQ1 affects cardiac long QT syndrome LQTS1
| 1
KCNQ1 activates cardiac long QT syndrome LQTS1. 1 / 1
| 1
reach
"Moreover, mutations in KCNQ1 can lead to dysfunction of the channel and cause the cardiac long QT syndrome LQTS1 that, in turn, may lead to serious arrhythmias, ventricular fibrillation and cardiac arrest."
19448982
KCNQ1 affects cardiac long QT
| 1
KCNQ1 activates cardiac long QT. 1 / 1
| 1
reach
"Mutations in KCNQ1 and KCNE1, the alpha- and beta-subunits of the I (KS) K+ channel, produce the cardiac long QT (LQT) syndrome."
12084623
KCNQ1 affects barium(2+)
| 1
KCNQ1 inhibits barium(2+). 1 / 1
| 1
sparser
"First, while at low external K + (1 μM and 2 mM) Ba 2+ virtually suppressed KCNQ1 inactivation, Ba 2+ left KCNQ1 inactivation intact at 50 mM [K + ] 0 , as revealed by the presence of the hook in tail currents ( xref A) with a fractional inactivation of ∼0.6 without and with Ba 2+ ( xref C)."
15226366
KCNQ1 affects atrial fibrillation
| 1
KCNQ1 activates atrial fibrillation. 1 / 1
| 1
reach
"Gain of function mutations in KCNQ1 can cause SQTS and atrial fibrillation XREF_BIBR, XREF_BIBR."
22039467
KCNQ1 affects apoptotic process
| 1
KCNQ1 activates apoptotic process. 1 / 1
| 1
reach
"Activation of the KCNQ1 and KCNE3 K+ current appeared to be an essential step in the LPS induced apoptosis process since HMR1556 blocked the LPS induced- cell volume decrease, -caspase-3 activation and -phosphatidylserine exposure."
20332617
KCNQ1 affects amiloride
| 1
KCNQ1 activates amiloride. 1 / 1
| 1
reach
"Ussing experiments showed that the pan-KCNQ channel blocker XE991, but not KCNQ1 selective blockers, reduced the short circuit current and the amiloride sensitive component."
18663467
KCNQ1 affects activity
| 1
KCNQ1 inhibits activity. 1 / 1
| 1
sparser
"R231A-KCNQ1 also inhibited activity of SMIT2, a SMIT1-related myo -inositol transporter encoded by SLC5A11 , while SMIT2 inhibited KCNQ1 activity, when the two were co-expressed in Xenopus oocytes [ xref ]."
28718502
KCNQ1 affects Wnt
| 1
KCNQ1 inhibits Wnt. 1 / 1
| 1
reach
"showed that KCNQ1 suppresses the Wnt and beta-catenin signaling pathway and forms complexes with beta-catenin and E-cadherin in the cell membrane."
29703730
KCNQ1 affects Wave
| 1
KCNQ1 binds Wave. 1 / 1
| 1
sparser
"LQT1 is associated with a broad-based T wave, LQT2 with a low amplitude notched or biphasic T wave, and LQT3 with a long isoelectric segment followed by a narrow-based T wave."
21382904
KCNQ1 affects VCL
| 1
KCNQ1-V141M activates VCL. 1 / 1
| 1
reach
"V141M KCNQ1 also caused a leftward shift of the conductance-voltage curve compared to wild type (WT) I Ks (V 1/2 = 33.6 +/- 4.0 mV for WT, and 24.0 +/- 1.3 mV for heterozygous V141M)."
29213224
KCNQ1 affects USP9X
| 1
KCNQ1 activates mutated USP9X. 1 / 1
| 1
reach
"This is the first study to link a known LQT1 mutation (R231C) to FAF and to show that an LQT1 mutation can generate a functional phenotype similar to the other KCNQ1 mediated FAF mutations."
20850564
KCNQ1 affects USP2-45/-69
| 1
KCNQ1 binds USP2-45/-69. 1 / 1
| 1
reach
"Our results demonstrated that both USP2-45 and -69 isoforms coimmunoprecipitated with KCNQ1, independently of the presence of Nedd4-2, indicating a direct interaction between KCNQ1 and USP2-45/-69."
22024150
KCNQ1 affects Type-1 long-QT syndrome
| 1
KCNQ1 activates Type-1 long-QT syndrome. 1 / 1
| 1
reach
"Type-1 long-QT syndrome (LQT1) is caused by mutations in the KCNQ1 gene."
19490272
KCNQ1 affects TLX2
| 1
KCNQ1 decreases the amount of TLX2. 1 / 1
| 1
reach
"Decreased expression of Kv4.3 alpha, KvLQT1 and L-Caalpha 1c but increased expression of NCX in HF patients."
23599743
KCNQ1 affects TGM2
| 1
KCNQ1 methylates TGM2. 1 / 1
| 1
sparser
"Bivariate regression analysis revealed a significant negative association between Kcnq1 gDMD methylation and accumulation of TGCs ( xref and xref )."
26241757
KCNQ1 affects T58V-MinK
| 1
KCNQ1 binds T58V-MinK. 1 / 1
| 1
reach
"Furthermore, swapping of this central residue of the " activation triplet " within the transmembrane domain between MinK and MiRP2 bestows the activation properties of either subunit on complexes formed with KCNQ1; T58V-MinK and KCNQ1 complexes exhibit a degree of constitutive activation, whereas V72T-MiRP2-KCNQ1 complexes produce slowly activating currents."
17227916
KCNQ1 affects Short QT
| 1
Mutated KCNQ1 activates Short QT. 1 / 1
| 1
reach
"In human cardiac muscle, KCNQ1 mutations cause Long and Short QT XREF_BIBR, XREF_BIBR."
23209695
KCNQ1 affects SQTS2
| 1
KCNQ1 activates SQTS2. 1 / 1
| 1
reach
"[XREF_BIBR] Gain of function mutations in three K + channel genes have been associated with SQTS, causing three syndromes-SQTS1 caused by mutations in hERG, SQTS2 caused by mutations in KCNQ1 and SQTS3 caused by mutations in KCNJ2."
26556967
KCNQ1 affects SQTS
| 1
KCNQ1 activates SQTS. 1 / 1
| 1
reach
"Gain of function mutations in KCNQ1 can cause SQTS and atrial fibrillation XREF_BIBR, XREF_BIBR."
22039467
KCNQ1 affects SQTL1
| 1
KCNQ1 activates SQTL1. 1 / 1
| 1
reach
"173 The most common mutation occurs in the KCNQ1 gene, which is responsible for more than 30% of the genetic variants and pathological mutations identified in LQTS and causes SQTL1."
30916199
KCNQ1 affects SLC5A1, and SLC5A11
| 1
SLC5A1 binds SLC5A11 and KCNQ1. 1 / 1
| 1
sparser
"KCNQ1 activity was augmented by SGLT1 (a sodium-dependent glucose transporter encoded by SLC5A1 ); it should be noted that physical interactions of KCNQ1 with SGLT1 and SMIT2 have yet to be established."
27789743
KCNQ1 affects SIL1
| 1
SIL1 binds KCNQ1. 1 / 1
| 1
sparser
"In the group of MSS tumours, low expression of KCNQ1 was associated with poor DFS in both stage II colon cancer patients (HR 3.82; 95% CI 2.04–7.14; P <0.0001; xref ) and stage III colon cancer patients (HR 2.93; 95% CI 1.70–5.02; P <0.0001; xref )."
27855440
KCNQ1 affects SHBG
| 1
KCNQ1 increases the amount of SHBG. 1 / 1
| 1
reach
"It was the first time to discover that rs163182 in KCNQ1 gene would raise the risk of MetS and elevate the level of BMI and SBP."
30157802
KCNQ1 affects SCD
| 1
KCNQ1 activates SCD. 1 / 1
| 1
reach
"The results suggest that the equine K V 7.1/KCNE1 channel may be important for cardiac repolarization and this could indicate that horses are susceptible to SCD caused by mutations in KCNQ1 and KCNE1."
28917093
KCNQ1 affects Rb
| 1
KCNQ1 activates Rb. 1 / 1
| 1
reach
"This has been explained by a suppression of KCNQ1 inactivation by Rb + ions caused by its long residence time in the KCNQ1 pore."
23183700
KCNQ1 affects REST
| 1
KCNQ1 activates REST. 1 / 1
| 1
reach
"On the paternal allele, the expression of the KCNQ1 silences all the subsequent genes in the domain, while in the maternal allele, the ICR methylation prevents expression of the KCNQ1, allowing the rest of the genes to be maternally expressed [XREF_BIBR, XREF_BIBR]."
25937812
KCNQ1 affects Perspectives Long QT syndrome type 1
| 1
KCNQ1 activates Perspectives Long QT syndrome type 1. 1 / 1
| 1
reach
"Clinical Perspectives Long QT syndrome type 1 (LQT1) is caused by mutations in the KCNQ1 gene resulting in a decrease in the repolarizing potassium current I Ks."
26318259
KCNQ1 affects PSMB5, PSMC1, PSMC2, PSMC3, PSMD1, PSMD12, PSMD13, PSMD3, PSMD6, PSMD7, and TRAF6
1 |
TRAF6 binds KCNQ1, PSMB5, PSMC1, PSMC2, PSMC3, PSMD1, PSMD12, PSMD13, PSMD3, PSMD6, and PSMD7. 1 / 1
1 |
hprd
No evidence text available
14743216
KCNQ1 affects PRKAR2A
1 |
KCNQ1 binds PRKAR2A. 1 / 1
1 |
biogrid
No evidence text available
11799244
KCNQ1 affects PPARG
| 1
KCNQ1 binds PPARG. 1 / 1
| 1
sparser
"Variants ADRA2A rs553668, IGF2BP2 rs4402960, KCNQ1 rs2237892, and PPARG rs1801282 were previously associated with T2D and identified by GWAS in European and/or Asian populations."
29800730
KCNQ1 affects PKA, and PPP1
| 1
PKA binds PPP1 and KCNQ1. 1 / 1
| 1
sparser
"With regard to disease processes leading to arrhythmia, it has been recently shown that the β-adrenergic signaling cascade involves the association of PKA and PP1 with the C-terminal domain of KCNQ1[ xref ] (the α-subunit of I Ks )."
20652086
KCNQ1 affects PEG10
| 1
PEG10 binds KCNQ1. 1 / 1
| 1
reach
"In contrast, the stronger associations between both Peg10 and Kcnq1 and E12.5 placental phenotypes were not occluded by confounding epistatic effects."
26241757
KCNQ1 affects PC/PG
| 1
KCNQ1 activates PC/PG. 1 / 1
| 1
reach
"The conserved nature of glycine at position 269 in the homologous proteins reflects the noteworthy importance of this residue in the structure and/or function of the S5 segment of KvLQT1 channel protein.The synthetic S5 segment of KvLQT1 induced the release of calcein from calcein entrapped PC/PG lipid vesicles much more efficiently than its mutant, Mut-S5, of the same size."
20044973
KCNQ1 affects Neoplasm Metastasis
| 1
KCNQ1 inhibits Neoplasm Metastasis. 1 / 1
| 1
reach
"In conclusion, KCNQ1 is down-regulated in HCC and may suppress HCC metastasis, which could represent a prognostic marker and promising therapeutic target for HCC."
30144972
KCNQ1 affects Neoplasm Invasiveness
| 1
KCNQ1 inhibits Neoplasm Invasiveness. 1 / 1
| 1
reach
"Overexpression of KCNQ1 trapped beta-catenin at the plasma membrane, induced a patent lumen in CRC spheroids, and slowed CRC cell invasion."
28373572
KCNQ1 affects MiRP1
| 1
KCNQ1 binds MiRP1. 1 / 1
| 1
reach
"Cysteine scanning mutagenesis in MiRP1 has been applied to study interactions between MiRP1 and KCNQ1 in parietal cells and results indicated that the transmembrane domain of MiRP1 adopted an alpha-helical secondary structure with one face making intimate contact with the KCNQ1 pore domain [17]."
21087668
KCNQ1 affects MTSS1
| 1
KCNQ1 activates MTSS1. 1 / 1
| 1
reach
"Mutations in KCNQ1 cause the autosomal recessive Jervell and Lange-Nielsen syndrome [MIM 220400], characterized by SNHL and cardiac abnormalities (long QT syndrome) (Jervell and Lange-Nielsen, 1957; Neyroud et al., 1997)."
25663387
KCNQ1 affects MTNR1B
| 1
KCNQ1 binds MTNR1B. 1 / 1
| 1
sparser
"Associations of MTNR1B [ xref ] and KCNQ1 [ xref ] with GDM were also identified in Korean studies."
28049284
KCNQ1 affects MT, and TG
| 1
KCNQ1 binds MT and TG. 1 / 1
| 1
sparser
"According to the results, the block of KCNQ1-related currents by HMR1556 contributed to complete functional restoration of the conduction system in the TG MT mice; however, HMR1556 had no effect on the ECG in either TG WT mice or wild-type mice, indicating that it was the S140G mutation rather than overexpression of KCNQ1 that was associated with AVBs in the TG MT mice."
17467630
KCNQ1 affects MSI
| 1
KCNQ1 binds MSI. 1 / 1
| 1
sparser
"In the group of MSI tumours, low expression of KCNQ1 was not significantly associated with DFS in stage II colon cancer patients (HR 3.37; 95% CI 0.38–30.17; P =0.278; xref ), but was associated with poor DFS in stage III colon cancer patients (HR 5.06; 95% CI 1.07–23.89; P =0.041; xref )."
27855440
KCNQ1 affects MAP6
| 1
KCNQ1 activates MAP6. 1 / 1
| 1
reach
"Direct sequencing of the KCNH2, KCNQ1 and SCN5A genes revealed a novel heterozygous frameshift mutation in the sixth exon of the KCNH2 gene producing a premature STOP codon : c. 1232_1234delinsTTTGAA (p.Asp411Valfs * 2)."
26577721
KCNQ1 affects MAP
| 1
KCNQ1 binds MAP. 1 / 1
| 1
sparser
"The identification of a secondary structure within the KCNE1 C-terminal domain provides a structural scaffold to map protein–protein interactions with the pore-forming KCNQ1 subunit as well as the cytoplasmic regulatory proteins anchored to KCNQ1–KCNE complexes."
17130521
KCNQ1 affects Long QT Syndrome type 1
| 1
KCNQ1 activates Long QT Syndrome type 1. 1 / 1
| 1
reach
"Long QT Syndrome type 1 (LQT1), an inherited cardiac ion channelopathy associated with arrhythmias and risk of sudden death, is caused by mutations in KCNQ1 encoding the alpha-subunit of Kv7.1, that affects the slow component of delayed rectifier K + current (I Ks) channel."
31415974
KCNQ1 affects Long QT Syndrome (LQTS) Type 1
| 1
Mutated KCNQ1 activates Long QT Syndrome (LQTS) Type 1. 1 / 1
| 1
reach
"KCNQ1 mutations underlie Long QT Syndrome (LQTS) Type 1 (LQT1), sub-classified as Romano Ward Syndrome (RWS; autosomal dominant) and Jervell Lange-Nielsen Syndrome (JLNS; typically autosomal recessive)."
20688187
KCNQ1 affects LQTs
| 1
KCNQ1 activates LQTs. 1 / 1
| 1
reach
"Mutations in KCNQ1 have been found to cause LQTs XREF_BIBR, XREF_BIBR."
23251633
KCNQ1 affects LQTS2 mutations
| 1
KCNQ1 activates LQTS2 mutations. 1 / 1
| 1
reach
"Moreover, KCNQ1 variably modulates LQTS2 mutations with distinct underlying pathologies."
20348026
KCNQ1 affects LQTS [
| 1
KCNQ1 inhibits LQTS [. 1 / 1
| 1
reach
"In addition to sequence variants, both deletions and duplications of KCNQ1 exon (s) are known to cause LQTS [XREF_BIBR, XREF_BIBR]."
25187895
KCNQ1 affects LQT-5
| 1
KCNQ1 activates LQT-5. 1 / 1
| 1
reach
"Genetic mutations in the alpha- (KCNQ1) and beta- (KCNE1) subunits of I (Ks) underlie Long QT Syndrome type 1 and 5 (LQT-1 and LQT-5), respectively, and predispose carriers to the development of polymorphic ventricular arrhythmias and sudden cardiac death."
15731462
KCNQ1 affects LQT-1
| 1
KCNQ1 activates LQT-1. 1 / 1
| 1
reach
"Genetic mutations in the alpha- (KCNQ1) and beta- (KCNE1) subunits of I (Ks) underlie Long QT Syndrome type 1 and 5 (LQT-1 and LQT-5), respectively, and predispose carriers to the development of polymorphic ventricular arrhythmias and sudden cardiac death."
15731462
KCNQ1 affects LQT syndrome type 1
| 1
KCNQ1 activates LQT syndrome type 1. 1 / 1
| 1
reach
"LQT syndrome type 1 (LQT1) is caused by a mutation in KCNQ1 (also known as KVLQT1 or K v7.1), which encodes the pore forming alpha subunits of the channels that generate I Ks, an adrenergic sensitive slow outward potassium current."
26274955
KCNQ1 affects Kv7.1
| 1
KCNQ1 activates Kv7.1. 1 / 1
| 1
reach
"Long QT Syndrome type 1 (LQT1), an inherited cardiac ion channelopathy associated with arrhythmias and risk of sudden death, is caused by mutations in KCNQ1 encoding the alpha-subunit of Kv7.1, that affects the slow component of delayed rectifier K + current (I Ks) channel."
31415974
KCNQ1 affects Kv2.1 channels
| 1
KCNQ1 inhibits Kv2.1 channels. 1 / 1
| 1
reach
"Previous studies have shown that KCNE peptides modulate K + channel activation and/or deactivation kinetics; for example, KCNE1 slows activation and deactivation of KCNQ1 XREF_BIBR, XREF_BIBR, and KCNE3 slows activation and deactivation of Kv2.1 channels in neurons XREF_BIBR."
19623261
KCNQ1 affects KNCE1
| 1
KCNQ1 binds KNCE1. 1 / 1
| 1
reach
"Based on the functional data, we suggest that the interaction between KNCE1 and KCNQ1 may be reversible and transient in a " Kiss & Go " manner, supporting a physiological role for KCNE1 as a dynamic regulatory molecule."
17845799
KCNQ1 affects KLF14
| 1
KCNQ1 binds KLF14. 1 / 1
| 1
sparser
"The aim of this investigation was to analyze the association of KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 polymorphisms with T2DM in Han Chinese people in Henan province, China."
26927145
KCNQ1 affects KCNQ3, and STX1A
| 1
STX1A binds KCNQ1 and KCNQ3. 1 / 1
| 1
sparser
"The present study establishes a novel interaction between syntaxin 1A and a specific member of the Kv7 family, KCNQ2, but not KCNQ3 or KCNQ1, which bind syntaxin 1A more weakly ( xref )."
19675672
KCNQ1 affects KCNQ2/3
| 1
KCNQ1 activates KCNQ2/3. 1 / 1
| 1
reach
"However, KCNQ4 and KCNQ1 homomers produce a K + current with an amplitude that is dramatically larger than those of KCNQ2 and KCNQ3 homomers, and KCNQ2/3 heteromers (9-12)."
22713565
KCNQ1 affects KCNQ1s
| 1
KCNQ1 binds KCNQ1s. 1 / 1
| 1
sparser
"All three mutant KCNQ1s assembled with wt KCNQ1 as determined by fluorescence resonance energy transfer (FRET)."
25344363
KCNQ1 affects KCNQ1 transmembrane protein
| 1
KCNQ1 activates KCNQ1 transmembrane protein. 1 / 1
| 1
reach
"The variations also resulted in a change of position of the splicing enhancer and inhibitor in KCNQ1 and exonic variations leading to truncated S2-S3 fragment of KCNQ1 transmembrane protein in cardiac cells with aberrant repolarization causing prolonged QTc."
27479201
KCNQ1 affects KCNE1-5
| 1
KCNQ1 binds KCNE1-5. 1 / 1
| 1
reach
"10,12,13 KCNQ1 can interact with KCNE1-5 to form complex currents."
17467630
KCNQ1 affects KCNE gene
| 1
KCNQ1 binds KCNE gene. 1 / 1
| 1
reach
"The third KCNE gene, KCNE3, is expressed in cardiac myocytes and interacts with KCNQ1 to change the channel properties."
19306396
KCNQ1 affects JPH2
| 1
JPH2 binds KCNQ1. 1 / 1
| 1
reach
"JPH-2 also interacts with Cav1.2 and KCNQ1, the pore forming subunits of L-type Ca (I CaL) and slow delayed rectifier (I Ks) channels."
26538326
KCNQ1 affects JNLS
| 1
KCNQ1 activates JNLS. 1 / 1
| 1
reach
"Our findings are the first in Korea to demonstrate that compound heterozygote mutations in KCNQ1 causes JNLS."
20890437
KCNQ1 affects JLNS variant
| 1
KCNQ1 activates JLNS variant. 1 / 1
| 1
reach
"Homozygous gene variants in KCNQ1, or compound heterozygous gene variants, may cause the recessive JLNS variant, which is characterized by deafness."
28595573
KCNQ1 affects JLN2
| 1
KCNQ1 activates JLN2. 1 / 1
| 1
reach
"Homozygous or compound heterozygous mutation in either KCNQ1 or KCNE1 (minK) causes the Jervell and Lange-Nielsen autosomal recessive form of the disease (JLN1 and JLN2, respectively), which is characterized by cardiac phenotype (long QT interval and susceptibility to ventricular arrhythmia) and sensorineural deafness."
20890437
KCNQ1 affects JLN variant
| 1
KCNQ1 activates JLN variant. 1 / 1
| 1
reach
"Homozygous mutations in KCNQ1, or compound heterozygous mutations, can cause the autosomal recessive JLN variant."
23684683
KCNQ1 affects JLN
| 1
KCNQ1 activates JLN. 1 / 1
| 1
reach
"At least 16 mutations in the KCNQ1 gene, typically recessive, cause JLN syndrome."
26084842
KCNQ1 affects IsK protein
| 1
KCNQ1 binds IsK protein. 1 / 1
| 1
reach
"These results indicate that the IsK protein associates with both KvLQT1 and ERG products to modulate IKr and IKs in cardiac myocytes."
11484762
KCNQ1 affects IsK channel
| 1
KCNQ1 binds IsK channel. 1 / 1
| 1
reach
"AKAP proteins anchor cAMP dependent protein kinase to KvLQT1 and IsK channel complex."
11299204
KCNQ1 affects ISK
| 1
KCNQ1 binds ISK. 1 / 1
| 1
reach
"Also, activation of the G-protein-coupled receptor, P2Y4, triggers PKC induced phosphorylation of the IsK (KCNE) auxiliary subunit, thereby inhibiting activity of the KCNQ1 and ISK complex that enables potassium entry into the endolymph."
21909974
KCNQ1 affects IRS-2/PI3K/Akt
| 1
KCNQ1 inhibits IRS-2/PI3K/Akt. 1 / 1
| 1
reach
"In this study, we found that a KCNQ1 selective inhibitor (chromanol 293B) increased the uptake of extracellular glucose and activated the IRS-2/PI3K/Akt pathway in normal and IR HepG2 cells, indicating that KCNQ1 has a pivotal role in regulating insulin signal transduction pathways under both physiological and pathological conditions."
27857189
KCNQ1 affects IRS-2/PI(3)K/Akt
| 1
KCNQ1 inhibits IRS-2/PI(3)K/Akt. 1 / 1
| 1
reach
"As predicted, the overexpression of KCNQ1 hindered glucose metabolism and diminished IRS-2/PI (3) K/Akt signaling in HepG2 cells (XREF_FIG)."
27857189
KCNQ1 affects IQ
| 1
KCNQ1 binds IQ. 1 / 1
| 1
sparser
"The results show that gintonin enhancesI Ks channel currents through the interaction of the Ca 2+ /CaM complex with KCNQ1 IQ motifs and that gintonin also increasesI Ks currents in guinea pig cardiac myocytes."
25234465
KCNQ1 affects IFH
| 1
KCNQ1 activates IFH. 1 / 1
| 1
reach
"In addition, TCF7L2 and KCNQ1 increased the risk of both IFH and IPH."
23990951
KCNQ1 affects ICR2
| 1
KCNQ1 leads to the methylation of ICR2. 1 / 1
| 1
reach
"Disruption of KCNQ1 prevents methylation of the ICR2 and supports the hypothesis that its transcription is necessary for imprint establishment."
30778172
KCNQ1 affects HSPA4
1 |
HSPA4 binds KCNQ1. 1 / 1
1 |
biogrid
No evidence text available
19114714
KCNQ1 affects Gly-Val
| 1
KCNQ1 activates Gly-Val. 1 / 1
| 1
reach
"The first step, leading to an intermediate-state, promoted the opening of homomeric KCNQ1 channels causing the GV to overlap with the first component of the FV (XREF_FIG)."
25535795
KCNQ1 affects Glu-Ser
| 1
KCNQ1 activates Glu-Ser. 1 / 1
| 1
reach
"Using an in silico search to identify not3 target genes, we found that not3 has been shown to bind to the Kcnq1 promoter in ES cells."
20371351
KCNQ1 affects GOLGA2
| 1 1
GOLGA2 binds KCNQ1. 1 / 1
| 1 1
sparser
"GM130 did not interact with the N or C terminus of either KvLQT1 or Shaker channels."
12270925
KCNQ1 affects GIP
| 1
KCNQ1 activates GIP. 1 / 1
| 1
reach
"Wolfram syndrome 1 gene (WFS1) has been associated with type 2 diabetes and with impaired insulin secretion during a GLP-1 infusion, and the variant rs151290 in KCNQ1 has been associated with changes in insulin secretion and increased GIP and GLP-1 secretion."
21525464
KCNQ1 affects GHD
| 1
KCNQ1 activates GHD. 1 / 1
| 1
reach
"We identified two missense mutations in KCNQ1 to underlie childhood onset of GHD and maternally inherited gingival fibromatosis."
29097701
KCNQ1 affects GFP
| 1
KCNQ1 binds GFP. 1 / 1
| 1
sparser
"We developed protocols to evaluate the interaction between the green fluorescent protein-tagged C-terminus of KCNQ1 (KCNQ1cL) and Ca2+-sensors by detecting its fluorescence in size exclusion chromatography and electrophoresed gels."
26184980
KCNQ1 affects FPDc
| 1
KCNQ1 inhibits FPDc. 1 / 1
| 1
reach
"FPDc was prolonged by blockade of the hERG channel (E-4031 and dl-sotalol) and KvLQT1 channel (chromanol 293B and HMR1556), and by activation of the sodium channel (veratridine) and calcium channel (Bay K8644)."
22198052
KCNQ1 affects F56Bpa
| 1
KCNQ1 binds F56Bpa. 1 / 1
| 1
reach
"UV induced cross linking suggested that F56Bpa interacts with KCNQ1 in the open state, whereas F57Bpa interacts predominantly in resting channel conformations."
28746852
KCNQ1 affects ERVK-18
| 1
ERVK-18 binds KCNQ1. 1 / 1
| 1
sparser
"However it is KCNE1 (also known as minK), a single transmembrane protein [ xref ], that co-assembles with KCNQ1 and imparts to the KCNQ1 channel its unique slow kinetics similar to that of the native I Ks recorded in cardiac myocytes [ xref , xref ]."
27261823
KCNQ1 affects ERK
| 1
KCNQ1 inhibits ERK. 1 / 1
| 1
reach
"Altogether, these data suggest that the inhibitory outcome of K + channel blockers could be due, at least in part, to the repressor activity of ERK1/2 on the alpha-ENaC promoter.Similarly to A549 cells, inhibition of KvLQT1 and K ATP channels in polarized primary ATII cells cultured on permeant filters also elicited strong activation of ERK1/2 at 15 min and 45 min."
22406554
KCNQ1 affects EGFR
1 |
EGFR binds KCNQ1. 1 / 1
1 |
biogrid
No evidence text available
28065597
KCNQ1 affects EBPL
| 1
KCNQ1-V307L inhibits EBPL. 1 / 1
| 1
reach
"In our simulations we found that the KCNQ1 V307L mutation reduces ERP at all rates."
28814790
KCNQ1 affects DBI
| 1
KCNQ1 activates DBI. 1 / 1
| 1
reach
"An additional K (+)-diffusion potential formed by KCNQ1 and KCNE1-K (+) channels at the apical membranes of marginal cells also contributes to the EP."
20012478
KCNQ1 affects CORO1A
| 1
CORO1A binds KCNQ1. 1 / 1
| 1
sparser
"Evidence indicates that VSELs freshly isolated from murine BM erase the paternally methylated imprints (e.g., at Igf2-H19 and Rasgrf1 loci); however, at the same time they hypermethylate the maternally methylated imprints (e.g., at the locus encoding the Igf2 receptor [Igf2R] and at the Kcnq1-p57 KIP2 and Peg1 loci)."
28057792
KCNQ1 affects CIB2
| 1
KCNQ1 increases the amount of CIB2. 1 / 1
| 1
reach
"In particular, a mutation has been identified at the KCNQ1 locus that increases the expression of p57 Kip2 in mouse pancreatic islets by epigenetically modifying Cdkn1c [XREF_BIBR]."
29614816
KCNQ1 affects CDH1
| 1
CDH1 binds KCNQ1. 1 / 1
| 1
sparser
"High expression of KCNQ1 was associated with high expression of E-cadherin."
29703730
KCNQ1 affects CDH
| 1
KCNQ1 activates CDH. 1 / 1
| 1
reach
"We hypothesized that KCNQ1, KCNQ4, and KCNQ5 expression is altered in the pulmonary vasculature of nitrofen induced CDH rats."
28189443
KCNQ1 affects BWS
| 1
KCNQ1 inhibits BWS. 1 / 1
| 1
reach
"KCNQ1 deletion causes BWS only when transmitted maternally and causes the syndrome through its effect on maternal CDKN1C expression."
22205991
KCNQ1 affects BOS_7381
1 |
KCNQ1 binds BOS_7381. 1 / 1
1 |
biogrid
No evidence text available
20861072
KCNQ1 affects BMI
| 1
KCNQ1 increases the amount of BMI. 1 / 1
| 1
reach
"It was the first time to discover that rs163182 in KCNQ1 gene would raise the risk of MetS and elevate the level of BMI and SBP."
30157802
KCNQ1 affects Arg-Trp
| 1
Mutated KCNQ1 activates Arg-Trp. 1 / 1
| 1
reach
"Heterozygous KCNQ1 mutations cause the dominant RW LQT1 syndrome and is the most common LQTS genotype accounting for 30-35% of LQTS."
23684683
KCNQ1 affects ATXN3
| 1
KCNQ1 binds ATXN3. 1 / 1
| 1
sparser
"An autosomal dominant form of LQT1, known as Romano–Ward syndrome, is the result of the dominant negative effect, where mutant channels are not only nonfunctional themselves, but also inhibit the function of any wild-type subunits present in the final assembled channel (Chouabe et al., 1997; Wollnik et al., 1997) ."
11448722
KCNQ1 affects ATP4A
1 |
KCNQ1 binds ATP4A. 1 / 1
1 |
biogrid
No evidence text available
17255364
KCNQ1 affects APC
| 1
KCNQ1 inhibits APC. 1 / 1
| 1
reach
"Loss of Kcnq1 enhances tumor multiplicity in Apc Min mice."
23975432
KCNQ1 affects AP2M1
1 |
AP2M1 binds KCNQ1. 1 / 1
1 |
biogrid
No evidence text available
23529131
KCNQ1 affects AGT
| 1
KCNQ1 activates AGT. 1 / 1
| 1
reach
"The single site mutation of either S95 or T96 in the N-terminus of KCNQ1 significantly attenuated the inhibition of Ang II compared to WT (P < 0.05, Fig. 5 C)."
29452158
KCNQ1 affects ADAMTS9
| 1
ADAMTS9 binds KCNQ1. 1 / 1
| 1
sparser
"Risk alleles in WFS1 rs10010131, IGF2BP2 rs4402960, CDKAL1 rs10946398, FTO rs8050136, KCNQ1 rs2237897, and ADAMTS9 rs4607103 were significantly associated with decreased homeostatic model assessment (HOMA)-β (P < 0.05)."
23298195
KCNQ1 affects 5-azaC
| 1
5-azaC binds KCNQ1. 1 / 1
| 1
isi
"We showed SMCHD1 binding to an intronic region of KCNQ1 that is lost following 5-azaC treatment suggesting DNA methylation facilitated binding of SMCHD1."
31941450
KCNH2 affects KCNQ1, and voltage-gated potassium channel
| 1
KCNH2 binds KCNQ1 and voltage-gated potassium channel. 1 / 1
| 1
sparser
"Both LQT1 and LQT2 are associated with loss of function of voltage-gated potassium channels (I Ks and I Kr ). xref "
20728018
KCNH2 affects KCNQ1, and ion channel
| 1
KCNH2 binds KCNQ1 and ion channel. 1 / 1
| 1
sparser
"The KCNH2 and KCNQ1 mutations are associated with different ion channel dysfunctions, xref , xref and gene specific triggers of arrhythmias. xref In LQT-1, it is recognized that exercise (catecholamine) is the primary trigger because of the malfunctioning I Ks channels that leads to less effective shortening of the QT intervals during tachycardia than in normal individuals."
23094878
KCNH2 affects KCNQ1, and hydrolase activity, acting on glycosyl bonds
| 1
Hydrolase activity, acting on glycosyl bonds binds KCNH2 and KCNQ1. 1 / 1
| 1
sparser
"Peptide N-glycosidase F-sensitive forms of horse ERG1 (145 kDa) and KCNQ1 (75 kDa) were detected."
12063283
KCNH2 affects KCNQ1, and Q1
| 1
KCNH2 binds KCNQ1 and Q1. 1 / 1
| 1
reach
"We have previously reported a physiologically relevant interaction between KCNQ1 (Q1) and KCNH2 (H2)."
25790957
KCNE4 affects KCNE5, and KCNQ1
| 1
KCNE5 binds KCNE4 and KCNQ1. 1 / 1
| 1
sparser
"We have reported interaction of KCNE4 and KCNE5 with KCNQ1, providing modulations of the KCNQ1 current ( Grunnet et al., 2002a ; Angelo et al., 2002 )."
12944270
KCNE3 affects KCNQ1, and S4
| 1
KCNE3 binds KCNQ1 and S4. 1 / 1
| 1
reach
"This observation is also consistent with the idea that, within the KCNQ1 and KCNE3 complex, the S4 segment is locked in the active state."
17698596
KCNE3 affects KCNQ1, and Q1
| 1
KCNE3 binds KCNQ1 and Q1. 1 / 1
| 1
reach
"Regulatory subunit KCNE3 (E3) interacts with KCNQ1 (Q1) in epithelia, regulating its activation kinetics and augmenting current density."
11956246
KCNE3 affects KCNE4, KCNQ1, and MAD2L2
| 1
KCNE3 binds KCNE4, KCNQ1, and MAD2L2. 1 / 1
| 1
sparser
"The channel complexes formed by the accessory subunit KCNE3 or KCNE4 and Kv7.1 were unaffected by the Q147R mutation."
17997361
KCNE2-5 subunits affects KCNQ1
| 1
KCNE2-5 subunits activates KCNQ1. 1 / 1
| 1
reach
"In view of our expression data, we considered the possibility that KCNE2-5 subunits might modulate KCNQ1 channels even in the presence of KCNE1."
15698834
KCNE2 affects KCNQ1, and tmd
| 1
KCNE2 binds KCNQ1 and tmd. 1 / 1
| 1
sparser
"The transmembrane domains (TMDs) of KCNE1 and KCNE2 were illustrated to associate with the KCNQ1 channel in different modes: Ile64 in KCNE2-TMD interacting with Phe340 and Phe275 in KCNQ1, while two pairs of interacting residues (Phe340-Thr58 and Ala244-Tyr65) in the KCNQ1/KCNE1 complex."
24827085
KCNE2 affects KCNQ1, and PSMD4
| 1
KCNE2 binds KCNQ1 and PSMD4. 1 / 1
| 1
sparser
"Mutations in KCNE2 and/or KCNQ1 have previously been associated with LQTS, AF, and even early-onset myocardial infarction ( xref ; xref ; xref ; xref ; xref ), each of which is also predisposed to by thyroid dysfunction in the general population ( xref ; xref ; xref ), suggesting the intriguing possibility of an endocrine component to some KCNE2- and KCNQ1-associated human cardiac disease."
20688187
KCNE1-beta subunits affects KCNQ1
| 1
KCNE1-beta subunits inhibits KCNQ1. 1 / 1
| 1
reach
"The mechanism by which KCNE1-beta subunits slow the kinetics of KCNQ1 channels is a matter of current controversy."
24769622
KCNE1-S102 affects KCNQ1
| 1
KCNE1-S102 activates KCNQ1. 1 / 1
| 1
reach
"However, a recent report has demonstrated that KCNE1-S102 contributes to the human KCNQ1 and KCNE1 stimulatory regulation by cPKC isoforms [43]."
29452158
KCNE1-D85N affects KCNQ1
| 1
KCNE1-D85N activates KCNQ1. 1 / 1
| 1
reach
"Verapamil (0.5-10 muM) increased the protein level of KCNE1-D85N, decreased its ubiquitination, slowed its degradation, and enhanced KCNQ1 and KCNE1-D 85N channel currents."
24499369
KCNE1-5 affects KCNQ1
| 1
KCNQ1 binds KCNE1-5. 1 / 1
| 1
reach
"10,12,13 KCNQ1 can interact with KCNE1-5 to form complex currents."
17467630
KCNE1 affects KCNQ1, and tmd
| 1
KCNE1 binds KCNQ1 and tmd. 1 / 1
| 1
reach
"The KCNQ1, KCNE1, and TMD complex models will then be expanded to include these domains of the channel complex, enhancing the power of these models to generate hypotheses for how KCNE1 modulates KCNQ1 activity."
21296569
KCNE1 affects KCNQ1, and phosphatidylinositol phosphate
| 1
Phosphatidylinositol phosphate binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"Similarly, mutations in Kv7.1 or KCNE1 that lead to a reduction in Kv7.1-PIP 2 affinity have been associated with congenital LQTS [114,136,137] ."
27818172
KCNE1 affects KCNQ1, and Yotiao
| 1
KCNE1 binds KCNQ1 and Yotiao. 1 / 1
| 1
reach
"Using a transgenic mouse strain expressing the KCNQ1-KCNE1 subunits of I Ks, we show that AC9 is the only adenylyl cyclase (AC) isoform associated with the KCNQ1, KCNE1, and Yotiao complex in the heart."
31461851
KCNE1 affects KCNQ1, and TEA
| 1
KCNE1 binds KCNQ1 and TEA. 1 / 1
| 1
sparser
"Conversely, we observe none of these pore-associated attributes for Cd 2+ block of channels containing MinK-55C and a KCNQ1 mutant (K318I, V319Y) that binds TEA with high affinity."
12770875
KCNE1 affects KCNQ1, RPS6, and tmd
| 1
RPS6 binds KCNE1, KCNQ1, and tmd. 1 / 1
| 1
sparser
"Several previous reports have demonstrated that the KCNE1-TMD interacts with the S6 segment or S4/S5 linker of KCNQ1."
24827085
KCNE1 affects KCNQ1, RPS6, and cooH
| 1
RPS6 binds KCNE1, KCNQ1, and cooH. 1 / 1
| 1
sparser
"As mentioned previously, disulfide cross-linking establishes an interaction between the KCNE1 proximal COOH terminus (residues 70–81) and the KCNQ1 S4/S5 linker (residues 251–257) as well as the S6 gate (residues 342–370; Lvov et al., xref )."
22529812
KCNE1 affects KCNQ1, and RPS6
| 1
RPS6 binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"Here, we identified a protein-protein interaction between the KCNE1 C-terminal domain and the KCNQ1 S6 activation gate and S4-S5 linker."
20479109
KCNE1 affects KCNQ1, and Q1C1
| 1
KCNE1 binds KCNQ1 and Q1C1. 1 / 1
| 1
sparser
"The sensorgrams (as shown in the example in xref ) could be fitted to a two-state binding model (as outlined in Materials and Methods) indicating that KCNQ1-Q1C1 associated with KCNE1 involving a conformational change."
20196769
KCNE1 affects KCNE3, KCNQ1, and tmd
| 1
KCNE1 binds KCNE3, KCNQ1, and tmd. 1 / 1
| 1
sparser
"This notion is illustrated by KCNE1 and KCNE3 chimeras carrying the KCNE4 C terminus, which act to inhibit rather than activate KCNQ1 ( xref ), suggesting that the KCNE4 C terminus is able to impose a KCNE4-like interaction between KCNQ1 and the TMD of either KCNE1 or KCNE3."
19687231
KCNE1 affects KCNE3, KCNE5, and KCNQ1
| 1
KCNE1 binds KCNE5, KCNE3, and KCNQ1. 1 / 1
| 1
sparser
"We determined inactivation properties and compared K+ vs. Rb+ inward currents for channels formed by co-assembly of KCNQ1 with KCNE1, KCNE3 and KCNE5, and for homomeric KCNQ1 channels with point mutations in the pore helix S5 or S6 transmembrane domains."
14561821
KCNE1 affects KCNE2, KCNH2, KCNQ1, SCN5A, and ion channel
| 1
SCN5A binds KCNE1, KCNE2, KCNH2, KCNQ1, and ion channel. 1 / 1
| 1
sparser
"To our knowledge, only one study has utilized sequencing to examine rare variation in unselected SCD cases from adult populations. xref , xref The entire coding sequence and splice junctions of five ion channel genes associated with IADS, SCN5A, KCNE1, KCNE2, KCNQ1 and KCNH2 , were directly sequenced in 113 cases of SCD. xref No unique or rare coding sequence variants were identified in any of the ion channel genes in 53 men. xref In 60 women with SCD, 6 rare missense variants (10%) were identified in the cardiac sodium channel gene (SCN5A) . xref The overall frequency of these rare variants in SCN5A was significantly higher in the SCD cases compared to 733 controls from the same population (1.6%; P=0.001), and subtle alterations in ion channel function were observed for 4 of the 5 variants."
22294707
KCNE gene affects KCNQ1
| 1
KCNQ1 binds KCNE gene. 1 / 1
| 1
reach
"The third KCNE gene, KCNE3, is expressed in cardiac myocytes and interacts with KCNQ1 to change the channel properties."
19306396
KCNE affects KCNQ1, and cysteine
| 1
KCNQ1 binds KCNE and cysteine. 1 / 1
| 1
reach
"To determine whether these two KCNE peptides influence voltage sensing in KCNQ1 channels, we monitored the position of the S4 voltage sensor in KCNQ1 and KCNE complexes using cysteine accessibility experiments."
18079560
KCN affects KCNE3, and KCNQ1
| 1
KCN binds KCNE3 and KCNQ1. 1 / 1
| 1
sparser
"The Kv7.1 protein may be also associated with MiRP2 protein to form the potassium channel ( xref )."
30420954
KCN affects KCNE1, KCNE3, and KCNQ1
| 1
KCN binds KCNE1, KCNE3, and KCNQ1. 1 / 1
| 1
sparser
"The KCNQ1 gene, encodes the Kv7.1 channel protein, which can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. xref In the human heart the KCNQ1 encodes the pore-forming α subunit, and KCNE1 (also known as minK) encodes the regulatory β subunit of the KCNQ1- KCNE1 complex responsible for I Ks , the slowly activating delayed rectifier K + repolarizing current. xref Mutations in KCNQ1 are associated with hereditary LQTS1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. xref In 2002, Marx et al showed that modulation of I KS β-adrenergic receptor stimulation requires targeting of cyclic adenosine 3′,5′-monophosphate (cAMP)–dependent PKA and protein phosphatase 1 (PP1) to hKCNQ1 through the A kinase-anchoring protein (AKAP)-9, also known as yotiao. xref These authors elegantly demonstrated that yotiao binds to the human KCNQ1 by a leucine zipper motif, which is disrupted by an LQTS mutation (hKCNQ1-G589D)."
26044251
K851AJAK3 affects KCNQ1
| 1
K851AJAK3 activates KCNQ1. 1 / 1
| 1
reach
"KCNE1 and KCNQ1 activity was significantly increased by wild-type JAK3 and A568VJAK3, but not by K851AJAK3."
26666518
JAK3 affects KCNQ1
| 1
JAK3 activates KCNQ1. 1 / 1
| 1
reach
"KCNE1 and KCNQ1 activity was significantly increased by wild-type JAK3 and A568VJAK3, but not by K851AJAK3."
26666518
IsK protein affects KCNQ1
| 1
KCNQ1 binds IsK protein. 1 / 1
| 1
reach
"These results indicate that the IsK protein associates with both KvLQT1 and ERG products to modulate IKr and IKs in cardiac myocytes."
11484762
IsK channel affects KCNQ1
| 1
KCNQ1 binds IsK channel. 1 / 1
| 1
reach
"AKAP proteins anchor cAMP dependent protein kinase to KvLQT1 and IsK channel complex."
11299204
ImKTx104 affects KCNQ1
| 1
ImKTx104 inhibits KCNQ1. 1 / 1
| 1
reach
"ImKTx104 selectively inhibited KCNQ1 channel with a K d of 11.69 microM, but was less effective against the basic KTxs sensitive potassium channels."
22511981
ISK affects KCNQ1
| 1
KCNQ1 binds ISK. 1 / 1
| 1
reach
"Also, activation of the G-protein-coupled receptor, P2Y4, triggers PKC induced phosphorylation of the IsK (KCNE) auxiliary subunit, thereby inhibiting activity of the KCNQ1 and ISK complex that enables potassium entry into the endolymph."
21909974
IQ affects KCNQ1
| 1
KCNQ1 binds IQ. 1 / 1
| 1
sparser
"The results show that gintonin enhancesI Ks channel currents through the interaction of the Ca 2+ /CaM complex with KCNQ1 IQ motifs and that gintonin also increasesI Ks currents in guinea pig cardiac myocytes."
25234465
IL1B affects KCNQ1
| 1
IL1B activates KCNQ1. 1 / 1
| 1
reach
"By contrast, the proinflammatory mediators IL-1beta (which originates from helper CD4 T lymphocytes, monocytes, macrophages and endothelial cells), and LTD 4 (another eicosanoid inflammatory mediator), both of which stimulate Cl - secretion in non inflamed mammalian colon XREF_BIBR, XREF_BIBR, failed to stimulate KCNQ1 and KCNE3 channel activity in control crypts, due to either the acute nature of our experiments, or the non involvement of KCNQ1 and KCNE3 channels in the Cl - -secretory effects of IL-1beta and LTD 4."
26718405
IKr affects KCNQ1
| 1
IKr activates KCNQ1. 1 / 1
| 1
reach
"After identification of the channel subunits underlying IKs, KCNQ1 associated with KCNE1, and IKr, HERG, their involvement in human cardiac channelopathies have provided various models allowing the description of the molecular mechanisms of the KCNQ1 and HERG channels trafficking, activity and regulation."
19683534
IK affects KCNQ1, and TYMS
| 1
TYMS binds IK and KCNQ1. 1 / 1
| 1
sparser
"The aim of this study was therefore to investigate the interaction of TMS with KCNQ1 and the respective K+current IK."
11944086
ICR affects KCNQ1
| 1
Methylated ICR decreases the amount of KCNQ1. 1 / 1
| 1
reach
"On the paternal allele, the expression of the KCNQ1 silences all the subsequent genes in the domain, while in the maternal allele, the ICR methylation prevents expression of the KCNQ1, allowing the rest of the genes to be maternally expressed [XREF_BIBR, XREF_BIBR]."
25937812
IC2 affects KCNQ1, and KCNQ1OT1
| 1
KCNQ1 binds KCNQ1OT1 and IC2. 1 / 1
| 1
sparser
"In the mouse, targeted deletion of the orthologous IC2 region results in growth restriction and loss of imprinting of six genes including Cdkn1c and Phlda2 when paternally inherited. xref By contrast, paternal transmission of 250–330 kb deletions, including most of the KCNQ1 gene, IC2 and KCNQ1OT1 is associated with normal phenotype in humans (refs. xref and xref ; also see xref )."
23243085
HeTx204 peptide affects KCNQ1
| 1
HeTx204 peptide inhibits KCNQ1. 1 / 1
| 1
reach
"HeTx204 peptide, with a CS-alpha and alpha fold scaffold, blocks both Kv1.3 and KCNQ1 channels."
22511981
HeTx203 affects KCNQ1
| 1
HeTx203 inhibits KCNQ1. 1 / 1
| 1
reach
"Toxins ImKTx104 and HeTx204 effectively blocked the KCNQ1 channel at 10 microM concentration, while LmKTx2 and HeTx203 only weakly inhibited the KCNQ1 channel at the same concentration, and 10 microM StKTx23 did not inhibit KCNQ1 channels."
22511981
HSPA4 affects KCNQ1
1 |
HSPA4 binds KCNQ1. 1 / 1
1 |
biogrid
No evidence text available
19114714
HMR1556 affects KCNQ1
| 1
HMR1556 inhibits KCNQ1. 1 / 1
| 1
reach
"HMR1556 blocks KCNQ1 and KCNE1 with a higher affinity than D609, but it also blocks I kr with an IC 50 of 12.6 microM (Thomas et al., 2003)."
29438706
H2 affects KCNH2, and KCNQ1
| 1
KCNH2 binds KCNQ1 and H2. 1 / 1
| 1
reach
"We have previously reported a physiologically relevant interaction between KCNQ1 (Q1) and KCNH2 (H2)."
25790957
GRB10 affects KCNQ1, RASGRF1, XIST, and YY1
| 1
XIST binds YY1, GRB10, KCNQ1, and RASGRF1. 1 / 1
| 1
sparser
"So far, two transcription factors are known to bind to DMRs: CTCF binds to the DMRs of H19 , Kcnq1 , Rasgrf1 , Grb10 , Dlk1/Gtl2 , Tsix and Xist , and YY1 binds to the DMRs of Nespas , Xist , Tsix and Peg3 ( xref )."
19628663
GOLGA2 affects KCNQ1
| 1 1
GOLGA2 binds KCNQ1. 1 / 1
| 1 1
sparser
"GM130 did not interact with the N or C terminus of either KvLQT1 or Shaker channels."
12270925
GO affects KCNK9, and KCNQ1
| 1
KCNK9 binds KCNQ1 and GO. 1 / 1
| 1
sparser
"Therefore, not surprisingly, the five maternally expressed genes Kcnk9 , Kcnq1 , Slca22a2 , Slca22a3 and Slca22a18 form a gene cluster that is associated with the same transport-related GO terms."
23226257
GNPTAB affects KCNE1, and KCNQ1
| 1
GNPTAB binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"The data we present here characterize a physical and functional interaction between the two K + channel subunits, KCNQ1 and KCNE1 residing in their intracellular C-termini."
20196769
GJB6 affects KCNQ1
| 1
GJB6 activates KCNQ1. 1 / 1
| 1
reach
"Gjb2 and Gjb6 genes produce the gap junction proteins, connexin 26 (Cx26) and connexin 30 (Cx30), while Cldn14 codes for a tight-junction protein; Kcne1, Kcnq1, and Kcnq4, all encoding for potassium ion channels; and finally Slc26a4 that encodes an anion transporter."
22567353
GJB2 affects KCNQ1
| 1
GJB2 activates KCNQ1. 1 / 1
| 1
reach
"Gjb2 and Gjb6 genes produce the gap junction proteins, connexin 26 (Cx26) and connexin 30 (Cx30), while Cldn14 codes for a tight-junction protein; Kcne1, Kcnq1, and Kcnq4, all encoding for potassium ion channels; and finally Slc26a4 that encodes an anion transporter."
22567353
GFP affects KCNQ1
| 1
KCNQ1 binds GFP. 1 / 1
| 1
sparser
"We developed protocols to evaluate the interaction between the green fluorescent protein-tagged C-terminus of KCNQ1 (KCNQ1cL) and Ca2+-sensors by detecting its fluorescence in size exclusion chromatography and electrophoresed gels."
26184980
FTO affects GCKR, KCNQ1, and TCF7L2
| 1
TCF7L2 binds FTO, GCKR, and KCNQ1. 1 / 1
| 1
sparser
"xref shows that TCF7L2 , CDKN2BAS , KCNQ1 , FTO and GCKR are significantly associated with IFH (OR ranged between 1.171–1.524; p value ranged between 0.0023–0.0476)."
23990951
F56Bpa affects KCNQ1
| 1
KCNQ1 binds F56Bpa. 1 / 1
| 1
reach
"UV induced cross linking suggested that F56Bpa interacts with KCNQ1 in the open state, whereas F57Bpa interacts predominantly in resting channel conformations."
28746852
Eu1.6 affects KCNQ1
| 1
Eu1.6 inhibits KCNQ1. 1 / 1
| 1
reach
"Furthermore, Eu1.6 did not inhibit voltage gated sodium channels in DRG neurons nor KCNQ1 channels or L- and T-type calcium channels expressed in HEK293 cells (Supp."
29343689
ESR1 affects KCNQ1, and MIER1
| 1
MIER1 binds ESR1 and KCNQ1. 1 / 1
| 1
sparser
"Using R3C, we confirmed that both the ectopically expressed ER6K and ER1 fragments directly interacted with the Kcnq1 promoter (D1/Ra and D6/Ra; xref , lanes 5 and 7) and the KvDMR1 region (D6/Ra and D6/Ra; xref , lanes 11 and 13)."
24395636
ERVK-18 affects KCNQ1
| 1
ERVK-18 binds KCNQ1. 1 / 1
| 1
sparser
"However it is KCNE1 (also known as minK), a single transmembrane protein [ xref ], that co-assembles with KCNQ1 and imparts to the KCNQ1 channel its unique slow kinetics similar to that of the native I Ks recorded in cardiac myocytes [ xref , xref ]."
27261823
EOF affects KCNQ1
| 1
EOF activates KCNQ1. 1 / 1
| 1
reach
"Effects of IGF2BP2, KCNQ1 and GCKR polymorphisms on clinical outcome in metastatic gastric cancer treated with EOF regimen."
26115082
ENO3 affects KCNE1, and KCNQ1
| 1
ENO3 binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"A tetramer of 4 KCNQ1 alpha subunits co-assembles with the minK gene product (beta regulatory subunit) to form the IKs slowly deactivating delayed rectifier potassium channel [ xref ]."
22275999
EHMT2 affects KCNQ1, KCNQ1OT1, and PRC2_complex
| 1
PRC2_complex binds EHMT2, KCNQ1, and KCNQ1OT1. 1 / 1
| 1
sparser
"Kcnq1ot1 interacts with PRC2 as well as the H3K9-specific histone methyltransferase G9a in a lineage-specific manner to mediate the silencing of the Kcnq1 gene in the paternal allele in placenta ( xref )."
24342564
EAF2 affects KCNQ1
| 1
EAF2 binds KCNQ1. 1 / 1
| 1
reach
"However, we did not find evidence of association between KCNQ1 and diabetic related quantitative traits."
29871606
EAF2 affects GCK, HHEX, KCNQ1, TBX5, and TCF7L2
| 1
TBX5 binds TCF7L2, EAF2, GCK, HHEX, and KCNQ1. 1 / 1
| 1
sparser
"We found that CAMTA1, ABI2, VHL, KAT2B, PKHD1, ESR1, TOX, SLC30A8, SFI1, and MYH9 polymorphisms were associated with HbA1c, FPG, and/or P2PG; GCK, HHEX, TCF7L2, KCNQ1, and TBX5 polymorphisms were associated with insulin resistance-related traits; ABCG2, SLC2A9, and PKHD1 polymorphisms were associated with SUA; CAMTA1, VHL, KAT2B, PON1, NUB1, SLITRK5, SMAD3, FTO, FANCA, and PCSK2 polymorphisms were associated with blood lipid traits; CAMTA1, SPAG16, TOX, KCNQ1, ACACB, and MYH9 polymorphisms were associated with blood pressure; and UBE2E3, SPAG16, SLC2A9, CDKAL1, CDKN2A/B, TCF7L2, SMAD3, and PNPLA3 polymorphisms were associated with BMI (all P values <0.05)."
26634513
E2 affects KCNQ1
| 1
E2 inhibits KCNQ1. 1 / 1
| 1
reach
"Then in 2011, they found that E2 reduced the currents with Ussing chamber mediated by the KCNQ1 : KCNE3 potassium channel rather than KCNQ1 : KCNE1 or KCNQ1 alone [XREF_BIBR]."
29228643
DNMT1 affects KCNQ1
| 1
DNMT1 methylates KCNQ1. 1 / 1
| 1
reach
"Then, the interaction between KCNQ1OT1 and the Kcnq1 and DNA methyltransferase 1 (DNMT1) axis was evaluated by measuring the level of Kcnq1 promoter region methylation and DNMT1 enrichment of the Kcnq1 promoter region."
31454677
DERL1 affects KCNQ1
| 1
DERL1 binds KCNQ1. 1 / 1
| 1
sparser
"Small interfering RNA knock-down of Derlin-1 did not modify KCNQ1 expression level, and no interaction between endogenous KCNQ1 and Derlin-1 could be detected."
19114714
Cterm-MinK affects KCNQ1
| 1
Cterm-MinK activates KCNQ1. 1 / 1
| 1
reach
"The recorded currents exhibit a phenotype identical to that of KvLQT1 alone (XREF_FIG C, left; XREF_TABLE), indicating that MiRP1 and Cterm-MinK either does not associate with and modulate KvLQT1 or that it is not expressed at the cell surface."
10962015
Cromakalim affects KCNQ1
| 1
Cromakalim inhibits KCNQ1. 1 / 1
| 1
reach
"Cromakalim, another chromanol compound, also blocked KvLQT1 currents."
9396783
Common variant loci affects KCNQ1
| 1
Common variant loci activates KCNQ1. 1 / 1
| 1
reach
"Common variant loci found in the current and prior studies include 5 genes previously established to cause monogenic LQTS (KCNQ1, KCNH2, SCN5A, KCNE1, and KCNJ2)."
24952745
CTSG affects KCNQ1
| 1
CTSG activates KCNQ1. 1 / 1
| 1
reach
"We noted that the discordance of the assays appeared to be mostly in terms of HELP-seq identifying additional hypomethylated loci, such as the alternative, non CpG island, non CG cluster promoter of KCNQ1, which appears to become hypomethylated in erythroid progenitor cells (XREF_FIG)."
19386619
CPT2 affects KCNQ1
| 1
CPT2 activates KCNQ1. 1 / 1
| 1
sparser
"MTX and CPT1 activated KCNQ1 by hydrogen bonding to the foot of the voltage sensor, a previously unidentified drug site which we also find to be essential for MTX activation of the related KCNQ2/3 channel."
30443601
CORO1A affects KCNQ1
| 1
CORO1A binds KCNQ1. 1 / 1
| 1
sparser
"Evidence indicates that VSELs freshly isolated from murine BM erase the paternally methylated imprints (e.g., at Igf2-H19 and Rasgrf1 loci); however, at the same time they hypermethylate the maternally methylated imprints (e.g., at the locus encoding the Igf2 receptor [Igf2R] and at the Kcnq1-p57 KIP2 and Peg1 loci)."
28057792
CFTR affects KCNQ1, and MUC2
| 1
CFTR binds KCNQ1 and MUC2. 1 / 1
| 1
sparser
"A promising model is via KCNQ1’ s functional interactions with CFTR and MUC2 ."
23975432
CDKAL1 affects KCNQ1, PRC1, and TCF7L2
| 1
TCF7L2 binds CDKAL1, KCNQ1, and PRC1. 1 / 1
| 1
sparser
"xref shows that TCF7L2 , CDKAL1 , KCNQ1 , and PRC1 are significantly associated with IPH (OR ranged between 1.154–1.709, p value ranged between 0.00038–0.03482)."
23990951
CDKAL1 affects HHEX, IGF2BP2, KCNQ1, SLC30A8, TCF7L2, and WFS1
| 1
TCF7L2 binds WFS1, SLC30A8, CDKAL1, IGF2BP2, HHEX, and KCNQ1. 1 / 1
| 1
sparser
"We observed consistent and significant associations of IGF2BP2 , WFS1 , CDKAL1 , SLC30A8 , CDKN2A/B , HHEX , TCF7L2 and KCNQ1 (8.5×10 −18 < P <8.5×10 −3 ), as well as nominal associations of NOTCH2 , JAZF1 , KCNJ11 and HNF1B (0.05< P <0.1) with T2D risk, which yielded odds ratios ranging from 1.07 to 2.09."
24376643
CDKAL1 affects HHEX, IGF2BP2, KCNJ11, KCNQ1, MTNR1B, PPARG, SLC30A8, and TCF7L2
| 1
TCF7L2 binds SLC30A8, CDKAL1, IGF2BP2, HHEX, KCNJ11, KCNQ1, MTNR1B, and PPARG. 1 / 1
| 1
sparser
"Other genes have been associated with T2DM such as TCF7L2 , SLC30A8 , HHEX , CDKAL1 , IGF2BP2 , CDKN2A/B , PPARG , KCNJ11 , KCNQ1 and MTNR1B , as determined through genome-wide association studies (GWAS) xref , xref ."
23349674
CDH1 affects KCNQ1
| 1
CDH1 binds KCNQ1. 1 / 1
| 1
sparser
"High expression of KCNQ1 was associated with high expression of E-cadherin."
29703730
CAV3 affects KCNE1, KCNE2, KCNJ2, KCNQ1, and SCN5A
| 1
SCN5A binds CAV3, KCNE1, KCNE2, KCNJ2, and KCNQ1. 1 / 1
| 1
sparser
"However, pathogenic variants associated with KCNQ1 , SCN5A , KCNE1 , KCNE2 , KCNJ2 , and CAV3 were not observed."
30079003
CALM affects KCNQ1, and KCNQ2
| 1
CALM binds KCNQ1 and KCNQ2. 1 / 1
| 1
sparser
"WT and mutant Kv7.1 C-termini and Kv7.2 C-terminus did interact with CaM as assayed by HIS3 induction in the GAL4 based yeast two-hybrid system ( Fig. 4 B) while the negative controls did not produce any signal."
17482572
CALM affects KCNE1, and KCNQ1
| 1
CALM binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"KCNE1 forms a ternary complex with wild-type KCNQ1 and Ca(2+)-CaM that prevents inactivation, facilitates channel assembly, and mediates a Ca(2+)-sensitive increase of IKS-current, with a considerable Ca(2+)-dependent left-shift of the voltage-dependence of activation."
16556865
CALM affects CAMK2_complex, KCNE1, and KCNQ1
| 1
CALM binds CAMK2_complex, KCNE1, and KCNQ1. 1 / 1
| 1
sparser
"Thus, the interaction of calmodulin and Kv7.1 appears to be critical for expression and function of I Ks , with the intriguing possibility that regulatory mechanisms could also involve some form of CaMKII interaction with calmodulin and Kv7.1 or KCNE1."
24600393
CA5B affects KCNQ1
| 1
CA5B inhibits KCNQ1. 1 / 1
| 1
reach
"Using a combination of Northern blot, competitive multiplex PCR and immunoblot assays, we found that CAVB reduces KCNE1 and KCNQ1 RNA in the canine ventricles by 70 and 80%, respectively."
12566121
Benzodiazepine L-7 affects KCNQ1
| 1
Benzodiazepine L-7 inhibits KCNQ1. 1 / 1
| 1
reach
"Benzodiazepine L-7 blocks KCNQ1 channels by binding to the S6 protein domain; normalized I-V curves and activation kinetics were not affected by the presence of L-7, suggesting that the block is voltage independent."
20478918
BOS_7381 affects KCNQ1
1 |
KCNQ1 binds BOS_7381. 1 / 1
1 |
biogrid
No evidence text available
20861072
BCL11A affects ETV3, GCKR, KCNQ1, KLF14, MTNR1B, TCF7L2, and ZFAND6
| 1
TCF7L2 binds BCL11A, ZFAND6, ETV3, GCKR, KCNQ1, MTNR1B, and KLF14. 1 / 1
| 1
sparser
"The results revealed that seven genomic loci, including BCL11A , GCKR , KLF14 , TCF7L2 , MTNR1B , KCNQ1 , and ZFAND6 were significantly associated with MetS-related components in T2D among Chinese."
26599349
BBR affects KCNQ1
| 1
BBR activates KCNQ1. 1 / 1
| 1
reach
"At 10 muM, BBR potentiated KCNQ1, KCNQ4, and KCNQ5 but not KCNQ3."
25735002
Aldosterone affects KCNQ1
| 1
Aldosterone increases the amount of KCNQ1. 1 / 1
| 1
reach
"Aldosterone down-regulates IK s by inhibiting the expression of KCNQ1 and KCNE1, thus delaying the ventricular repolarization."
25857626
ATXN3 affects KCNQ1
| 1
KCNQ1 binds ATXN3. 1 / 1
| 1
sparser
"An autosomal dominant form of LQT1, known as Romano–Ward syndrome, is the result of the dominant negative effect, where mutant channels are not only nonfunctional themselves, but also inhibit the function of any wild-type subunits present in the final assembled channel (Chouabe et al., 1997; Wollnik et al., 1997) ."
11448722
ATP4A affects KCNQ1
1 |
KCNQ1 binds ATP4A. 1 / 1
1 |
biogrid
No evidence text available
17255364
ATP1B1 affects CACNA1C, CAV3, KCNH2, and KCNQ1
| 1
CACNA1C binds CAV3, KCNH2, KCNQ1, and ATP1B1. 1 / 1
| 1
sparser
"We showed that ATP1B1 interacts with KCNH2, CACNA1C, KCNQ1and CAV3."
24952909
ASCL2 affects CD81, KCNQ1, and KCNQ1OT1
| 1
CD81 binds KCNQ1, KCNQ1OT1, and ASCL2. 1 / 1
| 1
sparser
"This is indeed the case, as we not only found significant enrichment of heterochromatin modifications in the overlapping Kcnq1-Cd81-Ascl2 region but also specific interaction of Kcnq1ot1 with Kcnq1 , Cd81 , and Ascl2 gene regions in comparison to the other regions in the Kcnq1 domain."
18951091
ARs affects KCNQ1, and NEUROD1
| 1
KCNQ1 binds NEUROD1 and ARs. 1 / 1
| 1
sparser
"These data indicate intimate association of KCNQ1 and beta2-ARs and that beta2-AR signaling can modulate the function of IKs channels under conditions of increased beta2-AR expression, even in the absence of exogenous beta-AR agonist."
15272004
AP2M1 affects KCNQ1
1 |
AP2M1 binds KCNQ1. 1 / 1
1 |
biogrid
No evidence text available
23529131
AOPEP affects CALM, and KCNQ1
| 1
CALM binds AOPEP and KCNQ1. 1 / 1
| 1
sparser
"Yeast two-hybrid assay also suggests that KCNQ1 associates with apo-CaM."
19333131
ANPEP affects KCNQ1, and ZMIZ1
| 1
ZMIZ1 binds ANPEP and KCNQ1. 1 / 1
| 1
sparser
"Tobacco smoking is associated with differential DNA methylation of the diabetes risk genes ANPEP , KCNQ1 and ZMIZ1 ."
26825526
AKAP9 affects KCNQ1, and leucine
| 1
AKAP9 binds KCNQ1 and leucine. 1 / 1
| 1
reach
"AKAP9 binds KCNQ1 carboxy terminus via a leucine zipper (LZ) motif."
21885989
AKAP9 affects KCNQ1, and TUBB3
| 1
TUBB3 binds AKAP9 and KCNQ1. 1 / 1
| 1
sparser
"Although most of this subset remains genotype negative, mutations occurring at 1% frequency have been identified in a variety of ion channels or channel interacting proteins: cytoskeletal protein ankyrin B (LQT4), xref KCNQ1 beta-subunit minK (LQT5), xref HERG beta-subunit MiRP1(LQT6), xref potassium channel Kir2.1 (LQT7), xref L-type calcium channel (Timothy syndrome/LQT8), xref caveolin-3 (LQT9), xref beta4 subunit of the sodium channel (LQT10), xref AKAP9 -encoded adaptor protein yotiao, which interacts with KCNQ1 (LQT11), xref and cytoskeletal sodium channel regulator α 1 -syntrophin (LQT12). xref "
18823823
AKAP9 affects KCNQ1, PKA, PPP1, and sch1
| 1
PKA binds PPP1, AKAP9, KCNQ1, and sch1. 1 / 1
| 1
sparser
"Notably, I KS activity is tightly regulated by PKA-dependent phosphorylation, and this phosphorylation is tuned by both local PKA and PP1 signaling cascades. xref In heart, yotiao directly associates with Kv7.1 to recruit both PKA and PP1 to regulate I KS phosphorylation and gating ( xref ). xref Moreover, the LQT1-causative mutation, G589D abolishes Kv7.1’s association with yotiao thereby disrupting the channel’s sensitivity to beta-adrenergic regulation. xref "
20724725
AKAP9 affects KCNE1, and KCNQ1
| 1
AKAP9 binds KCNE1 and KCNQ1. 1 / 1
| 1
sparser
"KCNQ1, Yotiao and KCNE1 were detected in the anti-KCNQ1 immunoprecipitates from all the cell groups, suggesting that the KCNQ1(A590T) or KCNQ1(G589D) mutation did not disrupt the KCNQ1–KCNE1–Yotiao interaction ( Fig. 4 )."
24713462
AKAP9 affects CAV3, KCNE1, KCNE2, KCNH2, KCNJ5, KCNQ1, SCN4B, SCN5A, and SNTA1
| 1
SCN4B binds SCN5A, SNTA1, CAV3, AKAP9, KCNE1, KCNE2, KCNH2, KCNJ5, and KCNQ1. 1 / 1
| 1
sparser
"The Romano-Ward syndrome, which occurs commonly in an autosomal dominant fashion, encompasses heterozygous mutations associated with KCNQ1 (LQT1), KCNH2 (LQT2), SCN5A (LQT3), KCNE1 (LQT5), KCNE2 (LQT6), CAV3 (LQT9), SCN4B (LQT10), AKAP9 (LQT11), SNTA1 (LQT12) and KCNJ5 (LQT13)."
26779509
AGT affects KCNQ1
| 1
AGT activates KCNQ1. 1 / 1
| 1
reach
"Biotinylation experiments confirm that Ang II pretreatment increases cell surface KCNQ1 but not KCNE1 (XREF_FIG)."
28611207
ADCY5 affects CDKN2A, CXXC1, HMGA2, KCNQ1, TCF7L2, and WFS1
| 1
TCF7L2 binds WFS1, ADCY5, CXXC1, HMGA2, KCNQ1, and CDKN2A. 1 / 1
| 1
sparser
"In addition, six CpG-SNP loci representing CDKN2A , TCF7L2 , HMGA2 , KCNQ1 , ADCY5 and WFS1 were associated with differential DNA methylation of surrounding CpG sites ( p  < 0.05, Fig.  xref and ESM Table  xref )."
23462794
ADAMTS9 affects KCNQ1
| 1
ADAMTS9 binds KCNQ1. 1 / 1
| 1
sparser
"Risk alleles in WFS1 rs10010131, IGF2BP2 rs4402960, CDKAL1 rs10946398, FTO rs8050136, KCNQ1 rs2237897, and ADAMTS9 rs4607103 were significantly associated with decreased homeostatic model assessment (HOMA)-β (P < 0.05)."
23298195
ACVR1C affects KCNQ1
| 1
ACVR1C increases the amount of KCNQ1. 1 / 1
| 1
reach
"mRNA levels of KCNH2 (Erg) and KCNQ1 (Kv7.1), the pore forming subunit for I Kr and I Ks respectively, were moderately increased by 20% in Alk7 -/- mice relative to controls (XREF_FIG)."
26882027
ACACB affects CAMTA1, KCNQ1, MYH9, SPAG16, and TOX
| 1
CAMTA1 binds TOX, SPAG16, KCNQ1, MYH9, and ACACB. 1 / 1
| 1
sparser
"We found that CAMTA1, ABI2, VHL, KAT2B, PKHD1, ESR1, TOX, SLC30A8, SFI1, and MYH9 polymorphisms were associated with HbA1c, FPG, and/or P2PG; GCK, HHEX, TCF7L2, KCNQ1, and TBX5 polymorphisms were associated with insulin resistance-related traits; ABCG2, SLC2A9, and PKHD1 polymorphisms were associated with SUA; CAMTA1, VHL, KAT2B, PON1, NUB1, SLITRK5, SMAD3, FTO, FANCA, and PCSK2 polymorphisms were associated with blood lipid traits; CAMTA1, SPAG16, TOX, KCNQ1, ACACB, and MYH9 polymorphisms were associated with blood pressure; and UBE2E3, SPAG16, SLC2A9, CDKAL1, CDKN2A/B, TCF7L2, SMAD3, and PNPLA3 polymorphisms were associated with BMI (all P values <0.05)."
26634513
ABCG1 affects FTO, KCNQ1, PHOSPHO1, SLC30A8, SREBF1, TCF7L2, and TXNIP
| 1
SREBF1 binds TCF7L2, PHOSPHO1, TXNIP, SLC30A8, FTO, KCNQ1, and ABCG1. 1 / 1
| 1
sparser
"Based on reproducible findings from the reviewed studies in different population groups, differentially methylated sites in TCF7L2, KCNQ1, ABCG1, TXNIP, PHOSPHO1, SREBF1, SLC30A8 , and FTO are potentially associated with T2D and their predictive powers may hold irrespective of different genetic backgrounds and different lifestyle or environmental pressures."
30564199
ABCC1 affects KCNA1, and KCNQ1
| 1
ABCC1 binds KCNA1 and KCNQ1. 1 / 1
| 1
sparser
"Polymorphisms in intron 15 of potassium voltage-gated channel, KQT-like subfamily member 1 ( KCNQ1 ) gene have been associated with type II diabetes (T2D) in Japanese genome-wide association studies (GWAS)."
21261977
5-azaC affects KCNQ1
| 1
5-azaC binds KCNQ1. 1 / 1
| 1
isi
"We showed SMCHD1 binding to an intronic region of KCNQ1 that is lost following 5-azaC treatment suggesting DNA methylation facilitated binding of SMCHD1."
31941450
3R,4S-293B affects KCNQ1
| 1
3R,4S-293B inhibits KCNQ1. 1 / 1
| 1
reach
"At high extracellular potassium concentrations the inhibition of KCNQ1 by 3R,4S-293B and 3S,4R-293B was unaffected."
11739240
3-methylcholanthrene affects KCNQ1
| 1
3-methylcholanthrene decreases the amount of KCNQ1. 1 / 1
| 1
reach
"Moreover, PC and MC (1 mM) decreased KCNQ1 protein expression (relative density : 0.58 +/- 0.08 and 0.16 +/- 0.05; P <.01)."
26854997
293B affects KCNQ1
| 1
293B inhibits KCNQ1. 1 / 1
| 1
reach
"The IC50 value for 293B to block KvLQT1 related current was not significantly modified by the presence of IsK (9.9 microM in the absence of IsK versus 9.8 microM in its presence)."
9396783
1muM SSD609 affects KCNQ1
| 1
1muM SSD609 inhibits KCNQ1. 1 / 1
| 1
reach
"However, similar to the inhibitory effects of SSD609 on KCNQ1 and KCNE1 (XREF_FIG), the perfusion of 1muM SSD609 also attenuated the KCNQ1 and KCNE3 currents (approximately 31.2% reversible current attenuation; XREF_FIG)."
26307551
17beta-estradiol affects KCNQ1
| 1
17beta-estradiol inhibits KCNQ1. 1 / 1
| 1
reach
"In whole cell patch-clamp analysis, 17beta-estradiol inhibited a chromanol 293B sensitive KCNQ1 channel current in isolated female rat distal colonic crypts."
17556370
1,4-dithiothreitol affects KCNQ1
| 1
1,4-dithiothreitol inhibits KCNQ1. 1 / 1
| 1
reach
"XREF_FIG shows that although DTT causes a modest negative shift in the V 0.5 values of KCNQ1 alone and KCNQ1 and KCNE1-WT, it causes a prominent positive shift in the V 0.5 value of KCNQ1 and KCNE1-F 54C, supporting the second prediction."
23183700
(3S,5R)-fluvastatin affects KCNQ1
| 1
(3S,5R)-fluvastatin inhibits KCNQ1. 1 / 1
| 1
reach
"Fluvastatin inhibition of Rab5 has been shown to mediate cPKC dependent trafficking regulation of the cardiac delayed rectifier KCNQ1 and KCNE1 channels."
31780674