INDRA statements for KCNN1

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
STX1A affects KCNN1
| 8
STX1A binds KCNN1. 8 / 8
| 8
sparser
"These data suggested that syntaxin 1A is specifically associated with rSK1 in rat brain."
12681380
sparser
"The immunoprecipitation and pull-down data suggested that rSK1 and syntaxin 1A interact in rat brain."
12681380
sparser
"These data indicate that rSK1 subunits and syntaxin 1A may interact, because they could be reciprocally co-immunoprecipitated from rat brain."
12681380
sparser
"Therefore immunocytochemical studies were performed to examine the relative subcellular localizations of these two proteins and determine whether rSK1 and syntaxin 1A could interact in vivo."
12681380
sparser
"However, an antiserum to a tagged rSK1 channel was able to immunoprecipitate co-expressed syntaxin 1A, although the surface expressed syntaxin 1A should not have interacted with the intracellularly located rSK1."
12681380
sparser
"This result placed doubt on the interaction between rSK1 and syntaxin 1A in rat brain."
12681380
sparser
"Therefore, the surface expressed syntaxin 1A should not interact with the intracellularly located rSK1."
12681380
sparser
"Control co-immunoprecipitation reactions were used to confirm the specificity of the syntaxin 1A-rSK1 interaction."
12681380
PAPSS1 affects KCNN1
| 6
PAPSS1 binds KCNN1.
| 5
KCNN1 binds PAPSS1. 2 / 2
| 2
sparser
"STORM super-resolution microscopy revealed that co-expressed IKCa and SK1 channel subunits were closely associated, a finding substantiated by measurement of FRET between co-expressed fluorophore-tagged subunits."
31048549
sparser
"While our finding is that parasite cleavage of HK is unlike that of host kallikrein cleavage of HK, it has been reported that S. mansoni homogenates do possess a kallikrein-like activity; this is associated with an uncharacterized 66 kDa protein, sK1, that has been described as hydrolyzing the kallikrein synthetic substrate d-Pro-Phe-Arg-p-nitroanilide [ xref ]."
29540224
KCNN1 binds KCNN2 and PAPSS1. 2 / 2
| 2
sparser
"The SK channels responsible for these effects are most likely formed by SK1 and SK2 subunits, while no [ xref , xref ] or only weak [ xref ] SK3 expression was detected in the DCN."
18597044
sparser
"The overexpression of rat SK1(LV213/4YA) subunits reduced the sensitivity of the medium afterhyperpolarization to apamin, substantiating the preferential co-assembly of SK1 and SK2 subunits to form heteromeric channels."
25421315
KCNN1 binds KCNN3 and PAPSS1. 1 / 1
| 1
sparser
"hSK1YP dramatically reduced the SK3 current, supporting the idea that SK3 and SK1 subunits also interact."
14559917
PAPSS1 inhibits KCNN1.
| 1
PAPSS1 inhibits KCNN1. 1 / 1
| 1
sparser
"The effects of DMS were virtually identical to those of Sk1 G82D -mediated inhibition of Sk1 ( xref )."
20930159
KCNN1 affects PAPSS1
| 6
KCNN1 binds PAPSS1.
| 5
KCNN1 binds PAPSS1. 2 / 2
| 2
sparser
"STORM super-resolution microscopy revealed that co-expressed IKCa and SK1 channel subunits were closely associated, a finding substantiated by measurement of FRET between co-expressed fluorophore-tagged subunits."
31048549
sparser
"While our finding is that parasite cleavage of HK is unlike that of host kallikrein cleavage of HK, it has been reported that S. mansoni homogenates do possess a kallikrein-like activity; this is associated with an uncharacterized 66 kDa protein, sK1, that has been described as hydrolyzing the kallikrein synthetic substrate d-Pro-Phe-Arg-p-nitroanilide [ xref ]."
29540224
KCNN1 binds KCNN2 and PAPSS1. 2 / 2
| 2
sparser
"The SK channels responsible for these effects are most likely formed by SK1 and SK2 subunits, while no [ xref , xref ] or only weak [ xref ] SK3 expression was detected in the DCN."
18597044
sparser
"The overexpression of rat SK1(LV213/4YA) subunits reduced the sensitivity of the medium afterhyperpolarization to apamin, substantiating the preferential co-assembly of SK1 and SK2 subunits to form heteromeric channels."
25421315
KCNN1 binds KCNN3 and PAPSS1. 1 / 1
| 1
sparser
"hSK1YP dramatically reduced the SK3 current, supporting the idea that SK3 and SK1 subunits also interact."
14559917
KCNN1 inhibits PAPSS1.
| 1
KCNN1 inhibits PAPSS1. 1 / 1
| 1
sparser
"The effects of DMS were virtually identical to those of Sk1 G82D -mediated inhibition of Sk1 ( xref )."
20930159
KCNN1 affects MAT2A
| 6
KCNN1 phosphorylates MAT2A.
| 5
KCNN1 phosphorylates MAT2A. 5 / 5
| 5
sparser
"One is that Hsk1 is capable of phosphorylating CDK consensus sites that are found in Ams2."
20604974
sparser
"We next examined whether Hsk1 kinase phosphorylates Ams2 in vitro."
20230746
sparser
"These results indicated that Hsk1 kinase phosphorylates Ams2 directly in vitro, and that at least one of the serine residues (S599 and S601) mutated in the M3 fragment is a major phosphorylation site."
20230746
sparser
"The observations outlined above strongly suggest that Hsk1 kinase directly phosphorylates Ams2."
20230746
sparser
"Hsk1 Kinase Promotes Phosphorylation and Degradation of Ams2."
20230746
KCNN1 binds MAT2A.
| 1
KCNN1 binds MAT2A and DAD2. 1 / 1
| 1
sparser
"These results suggest that Ams2 physically interacts with Hsk1 kinase through the Dfp1 subunit."
20230746
MBTPS1 affects KCNN1
| 4
MBTPS1 binds KCNN1.
| 3
MBTPS1 binds KCNN1. 2 / 2
| 2
sparser
"In this regard, it is well established that S1P 1 mediates cell migration and proliferation of various tumor cells, and an enhanced SK-1-dependent formation of S1P was found to be crucial for cancer progression (for review, see [38] )."
23906789
sparser
"Functionally, TZD-dependent increase in SK-1 activity and intracellular S1P formation were associated with lower amounts of the pro-fibrotic factor, connective tissue growth factor (CTGF) [4] , which was in line with the findings of Ren et al. [6] , who demonstrated an anti-fibrotic effect of intracellular S1P. In addition to the intracellular functions described above, S1P also acts as an extracellular ligand at five specific G protein-coupled receptors, termed S1P receptors (S1PR)."
23906789
MBTPS1 binds CCN2 and KCNN1. 1 / 1
| 1
sparser
"Functionally, TZD-dependent increase in SK-1 activity and intracellular S1P formation were associated with lower amounts of the pro-fibrotic factor, connective tissue growth factor (CTGF) [4] , which was in line with the findings of Ren et al. [6] , who demonstrated an anti-fibrotic effect of intracellular S1P. In addition to the intracellular functions described above, S1P also acts as an extracellular ligand at five specific G protein-coupled receptors, termed S1P receptors (S1PR)."
23906789
MBTPS1 activates KCNN1.
| 1
MBTPS1 activates KCNN1. 1 / 1
| 1
sparser
"Second, chemical inhibition of the three S1P receptors identified on ECs (ie, S1P 1 , S1P 2 , and S1P 3 ) 31 using JTE-013 and VPC23019 previously shown to inhibit S1P-induced SK-1 activation in HUVECs 17 failed to inhibit TNFα-induced activation of β 1 integrin (Figure 3D) ."
20522645
TNF affects KCNN1
| 3
TNF activates KCNN1. 3 / 3
| 3
sparser
"TNFα activated Sk1 and induced its translocation to the smooth muscle cell membrane."
20930159
sparser
"As shown in Figure 2 , TNFα activates SK-1 in a biphasic pattern with significant increases observed at 10 minutes and 4 to 6 hours after TNFα treatment."
20522645
sparser
"First, TNFα-induced activation of SK-1 in ECs was confirmed using an enzymatic assay."
20522645
KCNN1 affects MBTPS1
| 3
MBTPS1 binds KCNN1. 2 / 2
| 2
sparser
"In this regard, it is well established that S1P 1 mediates cell migration and proliferation of various tumor cells, and an enhanced SK-1-dependent formation of S1P was found to be crucial for cancer progression (for review, see [38] )."
23906789
sparser
"Functionally, TZD-dependent increase in SK-1 activity and intracellular S1P formation were associated with lower amounts of the pro-fibrotic factor, connective tissue growth factor (CTGF) [4] , which was in line with the findings of Ren et al. [6] , who demonstrated an anti-fibrotic effect of intracellular S1P. In addition to the intracellular functions described above, S1P also acts as an extracellular ligand at five specific G protein-coupled receptors, termed S1P receptors (S1PR)."
23906789
MBTPS1 binds CCN2 and KCNN1. 1 / 1
| 1
sparser
"Functionally, TZD-dependent increase in SK-1 activity and intracellular S1P formation were associated with lower amounts of the pro-fibrotic factor, connective tissue growth factor (CTGF) [4] , which was in line with the findings of Ren et al. [6] , who demonstrated an anti-fibrotic effect of intracellular S1P. In addition to the intracellular functions described above, S1P also acts as an extracellular ligand at five specific G protein-coupled receptors, termed S1P receptors (S1PR)."
23906789
KCNN1 affects DAD2
| 3
KCNN1 binds DAD2. 1 / 1
| 1
sparser
"This protein binds and activates Hsk1 kinase, which phosphorylates the MCM2 protein."
11402029
KCNN1 binds MAT2A and DAD2. 1 / 1
| 1
sparser
"These results suggest that Ams2 physically interacts with Hsk1 kinase through the Dfp1 subunit."
20230746
KCNN1 binds MRC1, DAD2, and Swi3 and Hsk1. 1 / 1
| 1
sparser
"Mrc1 interacts with Swi3 and Hsk1 proteins through its central segment (378-879) containing a SQ/TQ cluster, and this segment is sufficient for checkpoint reaction."
19422421
Syntaxin affects KCNN1
| 1 1
Syntaxin increases the amount of KCNN1.
| 1
Modified syntaxin increases the amount of KCNN1. 1 / 1
| 1
reach
"In contrast to data reported for other channels (e.g. the amiloride sensitive epithelial Na + channel, Saxena et al., 1999), we have found no evidence that co-expression of syntaxin 1A enhances the surface expression of rSK1)."
12681380
Syntaxin binds KCNN1.
| 1
KCNN1 binds syntaxin. 1 / 1
| 1
sparser
"As the GST/rSK1 fusion protein was able to pull-down syntaxin 1A, this also demonstrated that the rSK1 antiserum was not directly interacting with syntaxin in the earlier immunoprecipitation studies."
12681380
Calcium(2+) affects KCNN1
| 2
Calcium(2+) activates KCNN1. 2 / 2
| 2
reach
"The three small-conductance calcium activated K + channels KCa2.1 (SK1), KCa2.2 (SK2), and KCa2.3 (SK3), and the intermediate-conductance KCa3.1 channel (IK1, SK4) play important roles in various physiological functions by modulating calcium signaling cascades and regulating membrane potential."
18955585
reach
"We have used an antibody to the rat small conductance calcium activated potassium channel subtype 1 (rSK1) to immunoprecipitate proteins from rat brain."
12681380
TGFB affects KCNN1
| 2
TGFB activates KCNN1. 2 / 2
| 2
sparser
"38 In functional terms, our data show that the activation of SK-1 by TGFβ is involved in the regulation of the important profibrotic factor, CTGF."
19657322
sparser
"Moreover, in human podocytes, Ren et al. [10] demonstrated that activation of SK-1 by TGF-β 2 acts anti-fibrotic."
25601519
SKA-31 affects KCNN1
| 2
SKA-31 activates KCNN1. 2 / 2
| 2
reach
"While SKA-31 activated both KCa2.1 and KCa2.3 with an EC 50 of 2.9 muM, SKA-20 showed roughly 3-fold higher activity on KCa2.1 (EC 50 430 nM) than on KCa2.3 (EC 50 1.2 muM)."
18955585
reach
"Out of a library of 41 benzothiazoles we identified two compounds, SKA-20 (anthra [2,1-d] thiazol-2-ylamine) and SKA-31 (naphtho [1,2-d] thiazol-2-ylamine), which are 10-20 times more potent than riluzole and activate KCa2.1 with EC 50 s of 430 nM and 2.9 muM, KCa2.2 with EC 50 s of 1.9 muM, KCa2.3 with EC 50 s of 1.2 muM and 2.9 muM, and KCa3.1 with EC 50 s of 115 nM and 260 nM."
18955585
KCNN1 affects MRC1
| 2
KCNN1 phosphorylates MRC1.
| 1
KCNN1 phosphorylates MRC1. 1 / 1
| 1
sparser
"Hsk1 kinase vigorously phosphorylates Mrc1 in vitro, predominantly at non-SQ/TQ sites, but this phosphorylation does not seem to affect the Rad3 action on Mrc1."
21099360
KCNN1 binds MRC1.
| 1
KCNN1 binds MRC1, DAD2, and Swi3 and Hsk1. 1 / 1
| 1
sparser
"Mrc1 interacts with Swi3 and Hsk1 proteins through its central segment (378-879) containing a SQ/TQ cluster, and this segment is sufficient for checkpoint reaction."
19422421
KCNN1 affects MCM7
| 2
KCNN1 phosphorylates MCM7. 2 / 2
| 2
sparser
"This protein binds and activates Hsk1 kinase, which phosphorylates the MCM2 protein."
11402029
sparser
"A number of functions have been ascribed to the Cdc23/Mcm10 replication factor and some of these have been mapped to specific domains of the protein (Fig. xref ), such as in vitro stimulation of Hsk1 phosphorylation of Mcm2 [ xref ] and stimulation of pol α-primase function [ xref ]."
15941470
KCNN1 affects KCNN2, and PAPSS1
| 2
KCNN1 binds KCNN2 and PAPSS1. 2 / 2
| 2
sparser
"The SK channels responsible for these effects are most likely formed by SK1 and SK2 subunits, while no [ xref , xref ] or only weak [ xref ] SK3 expression was detected in the DCN."
18597044
sparser
"The overexpression of rat SK1(LV213/4YA) subunits reduced the sensitivity of the medium afterhyperpolarization to apamin, substantiating the preferential co-assembly of SK1 and SK2 subunits to form heteromeric channels."
25421315
KCNN1 affects Integrins
| 2
KCNN1 activates Integrins. 2 / 2
| 2
sparser
"Furthermore, TNF α -induced SK-1 activates α 5 β 1 integrin on human umbilical vein ECs (HUVEC) to promote the adhesion of neutrophils under shear stress, again the events appear to be S1P receptor independent and can be inhibited by FTY720 [ xref ]."
23316248
sparser
"This inhibition was not observed with the α v β 3 blocking antibody (LM609) (Figure 6B) , an integrin also activated by SK-1."
20522645
IGF1 affects KCNN1
| 2
IGF1 activates KCNN1. 2 / 2
| 2
sparser
"Notably, IGF-1, one of the most important physiological regulator of skeletal muscle regeneration (Pedersen and Febbraio, xref ), activates both SK isoforms, SK1 and SK2, and via specific transactivation of S1P 2 , exerts its myogenic action (Bernacchioni et al., xref )."
24324439
sparser
"These data demonstrate that enhanced biosynthesis of S1P, due to SK1 and SK2 activation induced by IGF-1, is responsible for the engagement of S1P 1 and S1P 3 and is negatively implicated in the mitogenic effect of the growth factor."
22788716
Small interfering RNA affects KCNN1
| 1
Small interfering RNA inhibits KCNN1. 1 / 1
| 1
sparser
"Significantly increased levels of ceramide specie C 16 were detected when SK-1 was inhibited by siRNA against SK-1 prior to treatment with R-MA ( xref left panel), while the levels of C 18 remained unaffected ( xref right panel)."
19609004
Peptide toxins affects KCNN1
| 1
Peptide toxins inhibits KCNN1. 1 / 1
| 1
reach
"Leiurotoxin I (Lei) and PO5, peptide toxins that share the RXCQ motif, potently blocked human SKCa2 and SKCa3 but not SKCa1, whereas maurotoxin, Pi1, Tskappa, and PO1 were ineffective."
11527975
New SL0101 analogue affects KCNN1
| 1
New SL0101 analogue inhibits KCNN1. 1 / 1
| 1
eidos
"They found that a new SL0101 analogue , SL0101 ( 1b ) , specifically inhibits RSK1 and 2 in vitro and suppresses proliferation , survival and migration of TNBC cells ."
30813401
Hsa-miR-892c-5p affects KCNN1
1 |
Transcriptionally active hsa-miR-892c-5p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-7848-3p affects KCNN1
1 |
Transcriptionally active hsa-miR-7848-3p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-764 affects KCNN1
1 |
Transcriptionally active hsa-miR-764 decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6893-3p affects KCNN1
1 |
Transcriptionally active hsa-miR-6893-3p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-6891-3p affects KCNN1
1 |
Transcriptionally active hsa-miR-6891-3p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6821-3p affects KCNN1
1 |
Transcriptionally active hsa-miR-6821-3p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6790-3p affects KCNN1
1 |
Transcriptionally active hsa-miR-6790-3p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-634 affects KCNN1
1 |
Transcriptionally active hsa-miR-634 decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6072 affects KCNN1
1 |
Transcriptionally active hsa-miR-6072 decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-5702 affects KCNN1
1 |
Transcriptionally active hsa-miR-5702 decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-5193 affects KCNN1
1 |
Transcriptionally active hsa-miR-5193 decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-506-5p affects KCNN1
1 |
Transcriptionally active hsa-miR-506-5p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-5000-3p affects KCNN1
1 |
Transcriptionally active hsa-miR-5000-3p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4796-3p affects KCNN1
1 |
Transcriptionally active hsa-miR-4796-3p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4750-3p affects KCNN1
1 |
Transcriptionally active hsa-miR-4750-3p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4454 affects KCNN1
1 |
Transcriptionally active hsa-miR-4454 decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4436a affects KCNN1
1 |
Transcriptionally active hsa-miR-4436a decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4256 affects KCNN1
1 |
Transcriptionally active hsa-miR-4256 decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-3934-5p affects KCNN1
1 |
Transcriptionally active hsa-miR-3934-5p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-378a-5p affects KCNN1
1 |
Transcriptionally active hsa-miR-378a-5p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-370-3p affects KCNN1
1 |
Transcriptionally active hsa-miR-370-3p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-3653-5p affects KCNN1
1 |
Transcriptionally active hsa-miR-3653-5p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3621 affects KCNN1
1 |
Transcriptionally active hsa-miR-3621 decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-3065-3p affects KCNN1
1 |
Transcriptionally active hsa-miR-3065-3p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-1306-5p affects KCNN1
1 |
Transcriptionally active hsa-miR-1306-5p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-125a-3p affects KCNN1
1 |
Transcriptionally active hsa-miR-125a-3p decreases the amount of KCNN1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Ferbam affects KCNN1
| 1
Ferbam activates KCNN1. 1 / 1
| 1
reach
"The carbamate GW542573X (XREF_FIG) in contrast selectively activates KCa2.1 channels, and has been termed " a true activator " because it can activate KCa2.1 even in the absence of Ca 2+ [XREF_BIBR, XREF_BIBR]."
23883298
Ceramide affects KCNN1
| 1
Ceramide inhibits KCNN1. 1 / 1
| 1
sparser
"In notoriously difficult to treat pancreatic cancer, manipulation of the ceramide/S1P ratio using ceramide analogs and SK1 inhibition improved sensitivity to gemicitibine therapy, whereas upregulating SK1 caused gemcitibine resistance."
23290775
[ 125 I ] -apamin affects KCNN1
| 1
KCNN1 binds [ 125 I ] -apamin. 1 / 1
| 1
reach
"If rSK1 is like hSK1 and can bind [125 I] -apamin with low affinity, demonstration of its presence in brain tissue should be possible in saturation experiments by extending the range of [125 I] -apamin concentrations beyond 1 nM."
11522325
SKalpha subunits affects KCNN1
| 1
SKalpha subunits activates KCNN1. 1 / 1
| 1
reach
"SKalpha subunits are products of the KCNN1 (K Ca 2.1; SK1), KCNN2 (K Ca 2.2; SK2) and KCNN3 (K Ca 2.3; SK3) genes, whereas IKalpha (K Ca 3.1; IK1; SK4) are encoded by the KCNN4 gene."
30104956
Reactive Oxygen Species affects KCNN1
| 1
Reactive Oxygen Species activates KCNN1. 1 / 1
| 1
sparser
"OxLDLs trigger a ROS-dependent activation of nSMase2 and SK1 and the subsequent generation of S1P that elicits the angiogenic response through S1PRs activation and VEGFR2 transactivation xref , xref ."
28212521
PRL affects KCNN1
| 1
PRL activates KCNN1. 1 / 1
| 1
sparser
"Here, we show that prolactin (PRL) biphasically activates the SK-1, but not the SK-2 subtype, in the breast adenocarcinoma cell-line MCF7."
17639048
PPP2C affects KCNN1
| 1
PPP2C dephosphorylates KCNN1. 1 / 1
| 1
sparser
"In vitro phosphatase assays showed that PP2Ac dephosphorylated both recombinant SK1 and a phosphopeptide based on the phospho-Ser(225) region of SK1."
18852266
PPARG affects KCNN1
| 1
PPARG activates KCNN1. 1 / 1
| 1
sparser
"Thus, PPARγ-dependent activation of SK-1 [6] , and upregulation of S1P 1 (this study) might be part of a coordinated action of this class of drugs that finally may turn out to be critical for tumor progression."
23906789
PO5 affects KCNN1
| 1
PO5 inhibits KCNN1. 1 / 1
| 1
reach
"Leiurotoxin I (Lei) and PO5, peptide toxins that share the RXCQ motif, potently blocked human SKCa2 and SKCa3 but not SKCa1, whereas maurotoxin, Pi1, Tskappa, and PO1 were ineffective."
11527975
PMAIP1 affects KCNN1
| 1
PMAIP1 phosphorylates KCNN1. 1 / 1
| 1
sparser
"PMA also induced phosphorylation of GFP-hSK1."
12124383
PDGF affects KCNN1
| 1
PDGF activates KCNN1. 1 / 1
| 1
sparser
"Consistently, the activation of PDGFRβ and SK1 by PDGF does not require nSMase2 and Cer, as shown in fro/fro mFbl."
23651497
MAPK affects KCNN1
| 1
MAPK activates KCNN1. 1 / 1
| 1
sparser
"Taken together, we demonstrate that isoflurane, in addition to its potent analgesic and anesthetic properties, protects against endothelial apoptosis most likely via SK1 and ERK MAPK activation."
22312298
Leiurotoxin I affects KCNN1
| 1
Leiurotoxin I inhibits KCNN1. 1 / 1
| 1
reach
"Leiurotoxin I (Lei) and PO5, peptide toxins that share the RXCQ motif, potently blocked human SKCa2 and SKCa3 but not SKCa1, whereas maurotoxin, Pi1, Tskappa, and PO1 were ineffective."
11527975
KCNN1 affects syntaxin
| 1
KCNN1 binds syntaxin. 1 / 1
| 1
sparser
"As the GST/rSK1 fusion protein was able to pull-down syntaxin 1A, this also demonstrated that the rSK1 antiserum was not directly interacting with syntaxin in the earlier immunoprecipitation studies."
12681380
KCNN1 affects progeny virion
| 1
KCNN1 activates progeny virion. 1 / 1
| 1
eidos
"Depletion of RSK1 / RSK2 by small interfering RNA or the specific inhibitor BI-D1870 suppresses KSHV lytic gene expression and progeny virion production , suggesting an essential role of RSK1 / RSK2 in KSHV lytic replication ."
18057234
KCNN1 affects lytic
| 1
KCNN1 activates lytic. 1 / 1
| 1
eidos
"Depletion of RSK1 / RSK2 by small interfering RNA or the specific inhibitor BI-D1870 suppresses KSHV lytic gene expression and progeny virion production , suggesting an essential role of RSK1 / RSK2 in KSHV lytic replication ."
18057234
KCNN1 affects invasion metastasis cancer cells different tumours
| 1
KCNN1 activates invasion metastasis cancer cells different tumours. 1 / 1
| 1
eidos
"RSK1 and 2 also promote the invasion and metastasis of cancer cells from different tumours such as breast , colon , kidney , stomach and prostate , through mechanisms including ( 1 ) inducing a FRA1 and c-jun-dependent transcriptional program related to epithelial-mesenchymal transition ( EMT ) ; ( 2 ) phosphorylating SH3P2 and blocking its anti-motility effects ; and ( 3 ) phosphorylating filamin A and suppressing the integrin activation through its increased binding activity [ 74 ] ."
30813401
KCNN1 affects growth
| 1
KCNN1 inhibits growth. 1 / 1
| 1
sparser
"SK-1 inhibited growth of the microalga Dunaliella salina."
23645384
KCNN1 affects functions
| 1
KCNN1 inhibits functions. 1 / 1
| 1
sparser
"Experimentally, Pushparaj et al 51 showed both in vitro and in vivo that silencing SK-1 inhibited several mast-cell effector functions triggered by FcεRI engagement, whereas silencing SK-2 had no effect."
22322303
KCNN1 affects channel protein 1
| 1
KCNN1 activates channel protein 1. 1 / 1
| 1
reach
"In this work, we tested the binding capacities of compounds that had the strongest inhibition capacity to MAO B (1 and 4) to also bind into the small conductance calcium activated channel protein 1 (KCNN1), since this is a novel target for the treatment of neurological diseases through activation."
30018949
KCNN1 affects cell population proliferation
| 1
KCNN1 activates cell population proliferation. 1 / 1
| 1
eidos
"RSK1 and 2 induce cell proliferation through phosphorylating substrates such as GSK3 , c-Fos , Cdc25C and p27kip1 , regulating the activity of cyclin-dependent kinases and increasing the protein level of cyclins ."
30813401
KCNN1 affects cell growth
| 1
KCNN1 activates cell growth. 1 / 1
| 1
eidos
"RSK1 and 2 promote cell growth through phosphorylating substrates , such as TSC2 , raptor and eEF2 kinase , leading to the activation of mTOR pathway and increased translation of growth factors ."
30813401
KCNN1 affects [ 125 I ] -apamin
| 1
KCNN1 binds [ 125 I ] -apamin. 1 / 1
| 1
reach
"If rSK1 is like hSK1 and can bind [125 I] -apamin with low affinity, demonstration of its presence in brain tissue should be possible in saturation experiments by extending the range of [125 I] -apamin concentrations beyond 1 nM."
11522325
KCNN1 affects RAD9
| 1
KCNN1 phosphorylates RAD9. 1 / 1
| 1
sparser
"We show that fission yeast Rad9, a 9-1-1 heterotrimeric checkpoint-clamp component, is phosphorylated by Hsk1(Cdc7), the Schizosaccharomyces pombe Dbf4-dependent kinase (DDK) homolog, in response to replication-induced DNA damage."
21095590
KCNN1 affects MCM2
| 1
KCNN1 phosphorylates MCM2. 1 / 1
| 1
sparser
"This protein binds and activates Hsk1 kinase, which phosphorylates the MCM2 protein."
11402029
KCNN1 affects KCNN3, and PAPSS1
| 1
KCNN1 binds KCNN3 and PAPSS1. 1 / 1
| 1
sparser
"hSK1YP dramatically reduced the SK3 current, supporting the idea that SK3 and SK1 subunits also interact."
14559917
KCNN1 affects JMJD6
| 1
JMJD6 binds KCNN1. 1 / 1
| 1
sparser
"The binding of SK-1 to lipid phosphatidylserine can enhance SK-1 activity and plasma membrane translocation [ xref ]."
23316248
KCNN1 affects IK
| 1
KCNN1 inhibits IK. 1 / 1
| 1
sparser
"SK1, SK2 and SK3 CCD peptides inhibit I K,Ca in atrial myocytes."
20689065
KCNN1 affects Cell Survival
| 1
KCNN1 activates Cell Survival. 1 / 1
| 1
eidos
"RSK1 and 2 promote cell survival through phosphorylating substrates such as CREB , Bad , Bim-EL and DAPK , decreasing the activity of pro-apoptotic molecules and inducing the transcription of pro-survival genes [ 2,72,73 ] ."
30813401
KCNN1 affects CDC19
| 1
KCNN1 phosphorylates CDC19. 1 / 1
| 1
sparser
"Purified Hsk1 phosphorylates the Cdc19 (Mcm2) subunit of the six-member minichromosome maintenance protein complex purified from fission yeast."
9705352
JMJD6 affects KCNN1
| 1
JMJD6 binds KCNN1. 1 / 1
| 1
sparser
"The binding of SK-1 to lipid phosphatidylserine can enhance SK-1 activity and plasma membrane translocation [ xref ]."
23316248
HFBF affects KCNN1
| 1
HFBF inhibits KCNN1. 1 / 1
| 1
reach
"KCNC3, KCNA6, KCNQ2, KCNE1, KCNN1, and KCTD19 genes encode potassium voltage gated channels and are downregulated by the HFBF (XREF_TABLE)."
24688594
ERK affects KCNN1
| 1
ERK phosphorylates KCNN1. 1 / 1
| 1
sparser
"The fact that ERK1/2-dependent Sk1 phosphorylation integrates several inflammatory cytokine inputs (e.g., IL1β, IL6) xref , xref highlights the additional potential of this suggested therapeutic approach as a more general means to interfere with the microvascular effects of inflammatory processes."
20930159
EGFR affects KCNN1
1 |
EGFR phosphorylates KCNN1 on Y109. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
DAD2 affects KCNN1, MRC1, and Swi3 and Hsk1
| 1
KCNN1 binds MRC1, DAD2, and Swi3 and Hsk1. 1 / 1
| 1
sparser
"Mrc1 interacts with Swi3 and Hsk1 proteins through its central segment (378-879) containing a SQ/TQ cluster, and this segment is sufficient for checkpoint reaction."
19422421
DAD2 affects KCNN1, and MAT2A
| 1
KCNN1 binds MAT2A and DAD2. 1 / 1
| 1
sparser
"These results suggest that Ams2 physically interacts with Hsk1 kinase through the Dfp1 subunit."
20230746
CCN2 affects KCNN1, and MBTPS1
| 1
MBTPS1 binds CCN2 and KCNN1. 1 / 1
| 1
sparser
"Functionally, TZD-dependent increase in SK-1 activity and intracellular S1P formation were associated with lower amounts of the pro-fibrotic factor, connective tissue growth factor (CTGF) [4] , which was in line with the findings of Ren et al. [6] , who demonstrated an anti-fibrotic effect of intracellular S1P. In addition to the intracellular functions described above, S1P also acts as an extracellular ligand at five specific G protein-coupled receptors, termed S1P receptors (S1PR)."
23906789
BCL2 affects KCNN1
| 1
BCL2 ubiquitinates KCNN1. 1 / 1
| 1
sparser
"Bcl-2 ubiquitination in SK1 or LKR with or without GO6976 treatment was tested by immunoprecipitation using anti-Bcl-2 antibody and immunoblotting with anti-ubiquitin antibody (Fig xref , left panel)."
26041886
APP affects KCNN1
1 |
Transcriptionally active APP decreases the amount of KCNN1. 1 / 1
1 |
biopax:ctd
No evidence text available
21298039
2-aminooctadec-4-ene-1,3-diol affects KCNN1
| 1
2-aminooctadec-4-ene-1,3-diol inhibits KCNN1. 1 / 1
| 1
sparser
"The earliest example of an SK inhibitor is N,N-dimethylsphingosine (DMS), a naturally occurring N-methyl derivative of sphingosine that inhibits both SK1 and SK2 with K i s of ~ 16 and ~ 14 µM, respectively ( xref )."
30060814
1b affects KCNN1
| 1
1b inhibits KCNN1. 1 / 1
| 1
eidos
"They found that a new SL0101 analogue , SL0101 ( 1b ) , specifically inhibits RSK1 and 2 in vitro and suppresses proliferation , survival and migration of TNBC cells ."
30813401