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phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading

KCNH7 affects GLO3
| 6 4
| 6 4
sparser
"Erg3 interacted with Glo3 to a similar level as the positive control Arf1, while the β-galactosidase activity was much lower with Pub1, which served a negative control ( xref B)."
sparser
"Thus, Glo3 potentially interacts with Erg3 also in vivo ."
sparser
"Since we detected the interaction between Glo3 and Erg3 by crosslinking, we verified the observation by a yeast two-hybrid analysis."
sparser
"To extend our results, we tested for genetic interactions between ERG3 and GLO3 and generated a Δ glo3 Δ erg3 double mutant."
reach
"Erg3 interacted with Glo3 to a similar level as the positive control Arf1, while the beta-galactosidase activity was much lower with Pub1, which served a negative control (XREF_FIG B)."
sparser
"This phenotype was enhanced in the Δ glo3 Δ erg3 double deletion strain, which was unable to grow at intermediate tryptophan levels, indicating that GLO3 and ERG3 interact genetically."
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"To extend our results, we tested for genetic interactions between ERG3 and GLO3 and generated a Deltaglo3 Deltaerg3 double mutant."
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"Since we detected the interaction between Glo3 and Erg3 by crosslinking, we verified the observation by a yeast two-hybrid analysis."
sparser
"The ArfGAP Glo3 interacts with the C-5 sterol desaturase Erg3."
reach
"Thus, Glo3 potentially interacts with Erg3 also in vivo."
KCNH7 affects ergosterol
| 8
KCNH7 activates ergosterol.
| 5
| 5
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"Therefore, it is possible that decreased ERG3 expression by tsa3 mutation may further decrease cellular ergosterol content and exacerbate cell viability in addition to the effect by Erg11 inhibition with fluconazole."
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"Expression of C. reinhardtii ERG3 cDNA in erg3 null yeast was able to restore ergosterol biosynthesis and reverse phenotypes associated with lack of ERG3 function."
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"Reintroduction of a wild-type ERG3 allele into the homozygous deletion mutant restored virulence, ergosterol synthesis, and susceptibility to azoles, confirming that these phenotypic changes were solely due to the inactivation of Erg3p."
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"These experiments demonstrate that expression of ERG3 from C. reinhardtii can restore ergosterol biosynthesis in erg3Delta yeast."
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"S. cerevisiae erg3 null mutants are viable, but are unable to synthesize ergosterol XREF_BIBR."
KCNH7 decreases the amount of ergosterol.
| 3
KCNH7 decreases the amount of ergosterol. 3 / 3
| 3
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"It has been reported that mutations in the ERG3 gene that reduce the amount of ergosterol causes drug resistance in various fungal strains by stripping the drug of its intended target [XREF_BIBR - XREF_BIBR]."
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"It has been reported that mutations in the ERG3 gene that reduce the amount of ergosterol causes drug resistance in various fungal strains by stripping the drug of its intended target [66-68]."
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"Similarly, resistance against amphotericin and echinocandins is rare; however, it does occur if levels of the plasma membrane ergosterol and the cell wall (1,3)-beta-D-glucan are reduced by mutations in the ERG3 and GSC1 genes, respectively [XREF_BIBR]."
RIPK1 affects KCNH7
| 4
RIPK1 activates KCNH7.
| 3
RIPK1 activates mutated KCNH7. 3 / 3
| 3
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"Consequently, the frequency of RIP induced erg-3 mutants remains about constant regardless of the time that has elapsed between ascospore harvest and germination."
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"We found, however, that RIP induced erg-3 mutants were apparently selectively lost with time from among the ascospores stored from a cross with the wild isolated Carrefour Mme. Gras strain from Haiti."
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"Ordinarily, RIP induced erg-3 mutant Neurospora crassa ascospores and their erg (+) siblings do not differ in stability during long-term storage."
RIPK1 inhibits KCNH7.
| 1
RIPK1 inhibits mutated KCNH7. 1 / 1
| 1
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"Similar loss of RIP induced erg-3 mutant ascospores was seen among the stored ascospores from a subset of crosses heterozygous for the semi-dominant Sad-1 or Sad-2 suppressors of meiotic silencing."
KCNH7 affects ERG8
| 2 1
| 2 1
sparser
"Thus, BiFC assay demonstrated interaction between ERG3 and ERG8 variants in live cells."
reach
"Further, we showed a physical association between ERG3 and ERG8 in live cells by the bimolecular fluorescence complementation assay, providing a basis for the observed effects."
sparser
"To address the underlying basis for the interference of TMPRSS2-ERG3 mediated functions by TMPRSS2-ERG8 , we assessed the potential interaction between ERG3 and ERG8 proteins through fluorescence microscopy and flow cytometry using the bimolecular fluorescence complementation (BiFC) assay in live cells."
DNAH5 affects KCNH7, KIAA1109, NRXN1, and ZFHX4
| 3
KCNH7 binds KIAA1109, DNAH5, ZFHX4, and NRXN1. 3 / 3
| 3
sparser
"We found that mutations in ZFHX4, SPHKAP, NRXN1, KIAA1109, DNAH5 and KCNH7 were associated with poor overall survival."
sparser
"Importantly, mutations in ZFHX4, SPHKAP, NRXN1 , KIAA1109 , DNAH5 and KCNH7 were associated with poor survival."
sparser
"Survival analysis of frequently mutated genes in patients suggested that mutations in ZFHX4 , SPHKAP , NRXN1 , KIAA1109 , DNAH5 and KCNH7 were associated with poor prognosis."
Sertindole affects KCNH7
| 2
| 2
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"Block of erg3 by sertindole also displayed a positive voltage-dependence."
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"The antipsychotic drugs sertindole and pimozide block erg3, a human brain K (+) channel."
Fluconazole affects KCNH7
| 2
| 2
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"We found that ERG3 and ERG11 were normally induced by fluconazole treatment in UPR mutants, indicating that the UPR pathway is not likely to be directly involved in ergosterol biosynthesis."
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"However, while the addition of 5 microg/ml fluconazole increased the ERG3 transcript three- to fourfold in both wild-type and lnprERG3 strains, this response was not observed in the shprERG3 strain."
Ergosterol affects KCNH7
| 2
Ergosterol decreases the amount of KCNH7.
| 1
Ergosterol decreases the amount of KCNH7. 1 / 1
| 1
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"A block in the ergosterol biosynthetic pathway up-regulates ERG3 expression Thus far, regulation of ergosterol biosynthesis has focused e a enzymatic steps in the pre-lanosterol portion of the path- x ~ ay."
Ergosterol activates KCNH7.
| 1
| 1
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"Our genetic inactivation experiment of the oxygen dependent ergosterol biosynthetic genes in C. albicans (ERG1, ERG3, and ERG11) underlined an essential role of the C-5 sterol desaturase Erg3 for hypoxic growth (XREF_FIG)."
NOG affects KCNH7
2 |
Transcriptionally active NOG increases the amount of KCNH7. 2 / 2
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biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
KCNH7 affects fluconazole
| 2
KCNH7 inhibits fluconazole.
| 1
Mutated KCNH7 inhibits fluconazole. 1 / 1
| 1
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"None of the leaky fluconazole resistance erg3 mutations observed were altered in these residues and this might be expected as they retained some activity."
KCNH7 activates fluconazole.
| 1
Mutated KCNH7 activates fluconazole. 1 / 1
| 1
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"However, deletion of both HDA1 and RPD3 in an erg3 mutant reduced fluconazole resistance back to wild-type levels, similar to the impact of trichostatin A (XREF_FIG C and XREF_FIG A)."
| 2
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"Expression of C. reinhardtii ERG3 cDNA in erg3 null yeast was able to restore ergosterol biosynthesis and reverse phenotypes associated with lack of ERG3 function."
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"These experiments demonstrate that expression of ERG3 from C. reinhardtii can restore ergosterol biosynthesis in erg3Delta yeast."
KCNH7 affects SEPSECS
| 2
Mutated KCNH7 activates SEPSECS. 2 / 2
| 2
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"It should be noticed that pso6 and erg3 mutants were also sensitive to NDEA, but not to 8HQ, most probably due to the inability of 8HQ to cause LP [103]."
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"It should be noticed that pso6 / erg3 mutants were also sensitive to NDEA, but not to 8HQ, most probably due to the inability of 8HQ to cause LP [49]."
KCNH7 affects HSP42
| 2
KCNH7 increases the amount of HSP42.
| 1
KCNH7 increases the amount of HSP42. 1 / 1
| 1
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"In surprising results, we discovered that Rvs167p, which has previously been shown to play a direct role in the internalization step of endocytosis, associates with the SAGA complex, detected only in the erg3 mutant, and is required for the erg3 dependent increase in HSP42 and HSP104 mRNA expression."
KCNH7 activates HSP42.
| 1
KCNH7 activates HSP42. 1 / 1
| 1
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"The function of Rvs167p in the nucleus is not an indirect consequence of the block in the endocytic pathway because the rvs161 mutant, which has the same endocytic phenotype as rvs167, did not block the erg3 -- dependent induction of HSP42 and HSP104."
KCNH7 affects ERG6
| 1 1
| 1
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"Second, Parsons et al. [XREF_BIBR] concluded from ERG2, ERG3, ERG4 and ERG6 interactions that ergosterol synthesis affects multidrug resistance."
KCNH6 binds KCNH7, ERG4, and ERG6. 1 / 1
| 1
sparser
"Second, Parsons et al . [ xref ] concluded from ERG2 , ERG3 , ERG4 and ERG6 interactions that ergosterol synthesis affects multidrug resistance."
KCNH7 affects ERG4
| 1 1
| 1
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"Second, Parsons et al. [XREF_BIBR] concluded from ERG2, ERG3, ERG4 and ERG6 interactions that ergosterol synthesis affects multidrug resistance."
KCNH6 binds KCNH7, ERG4, and ERG6. 1 / 1
| 1
sparser
"Second, Parsons et al . [ xref ] concluded from ERG2 , ERG3 , ERG4 and ERG6 interactions that ergosterol synthesis affects multidrug resistance."
KCNH7 affects ERG11
| 2
| 2
sparser
"Here, we identified that the null mutants of ERG3 and ERG11, two key genes in ergosterol biosynthesis pathway, can form typical hyphae but failed to cause the oral mucosal infection in vitro and in vivo for the first time."
sparser
"Southern analysis of L. maculans chromosomal DNA revealed binding of erg3 and erg11 fragments to the largest chromosomal DNA bands sized 4.2, 3.6 and 3.2 Mb in isolate M1, and 3.6, 3.6 and 2.9 Mb in isolate C13 ( Fig. 3 )."
KCNH7 affects 1H-pyrrole
| 2
KCNH7 inhibits 1H-pyrrole.
| 1
Mutated KCNH7 inhibits 1H-pyrrole. 1 / 1
| 1
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"C. albicans erg3 mutants are able to resist both polyene and azole treatment [XREF_BIBR]."
KCNH7 activates 1H-pyrrole.
| 1
| 1
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"The resulting nonsynonymous mutation yielded a nonfunctional Erg3 protein, which triggered azole resistance."
HSP90 affects KCNH7
| 1 1
HSP90 binds KCNH7.
| 1
| 1
sparser
"Hsp90 mediated azole resistance is associated with loss of erg3 function, leading to accumulation of ergosta-7,22-dienol in C. albicans ."
HSP90 activates KCNH7.
| 1
HSP90 activates KCNH7. 1 / 1
| 1
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"By chaperoning Calcineurin, Hsp90 therefore allows the ERG3 variants to persist in the population and contribute to the evolution of drug resistance."
ERG6 affects KCNH7
| 1 1
| 1
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"Second, Parsons et al. [XREF_BIBR] concluded from ERG2, ERG3, ERG4 and ERG6 interactions that ergosterol synthesis affects multidrug resistance."
KCNH6 binds KCNH7, ERG4, and ERG6. 1 / 1
| 1
sparser
"Second, Parsons et al . [ xref ] concluded from ERG2 , ERG3 , ERG4 and ERG6 interactions that ergosterol synthesis affects multidrug resistance."
ERG4 affects KCNH7
| 1 1
| 1
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"Second, Parsons et al. [XREF_BIBR] concluded from ERG2, ERG3, ERG4 and ERG6 interactions that ergosterol synthesis affects multidrug resistance."
KCNH6 binds KCNH7, ERG4, and ERG6. 1 / 1
| 1
sparser
"Second, Parsons et al . [ xref ] concluded from ERG2 , ERG3 , ERG4 and ERG6 interactions that ergosterol synthesis affects multidrug resistance."
ERG11 affects KCNH7
| 2
| 2
sparser
"Here, we identified that the null mutants of ERG3 and ERG11, two key genes in ergosterol biosynthesis pathway, can form typical hyphae but failed to cause the oral mucosal infection in vitro and in vivo for the first time."
sparser
"Southern analysis of L. maculans chromosomal DNA revealed binding of erg3 and erg11 fragments to the largest chromosomal DNA bands sized 4.2, 3.6 and 3.2 Mb in isolate M1, and 3.6, 3.6 and 2.9 Mb in isolate C13 ( Fig. 3 )."
Tsa3 mutation affects KCNH7
| 1
Tsa3 mutation increases the amount of KCNH7. 1 / 1
| 1
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"Therefore, it is possible that decreased ERG3 expression by tsa3 mutation may further decrease cellular ergosterol content and exacerbate cell viability in addition to the effect by Erg11 inhibition with fluconazole."
Sirolimus affects KCNH7
| 1
| 1
reach
"Although the expressions of p53, p21 Cip1, p27 Kip1 and cyclin D 1 mRNAs did not significantly change, we found that expressions of several genes such as cyclin G 2, TGFBI, BIK, GRB7 and ERG3 were markedly modulated in MCF-7 cells treated with rapamycin plus CN-A."
Rvs161 mutant affects KCNH7
| 1
Rvs161 mutant inhibits KCNH7. 1 / 1
| 1
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"The function of Rvs167p in the nucleus is not an indirect consequence of the block in the endocytic pathway because the rvs161 mutant, which has the same endocytic phenotype as rvs167, did not block the erg3 -- dependent induction of HSP42 and HSP104."
Rpr affects KCNH7
| 1
Rpr inhibits KCNH7. 1 / 1
| 1
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"These residues are conserved in the highly homologous ether-a-go-go-related gene 3 (ERG3) subunit; however, RPR blocks ERG3 channels."
Pimozide affects KCNH7
| 1
| 1
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"The antipsychotic drugs sertindole and pimozide block erg3, a human brain K (+) channel."
MiR-30 affects KCNH7
| 1
MiR-30 activates KCNH7. 1 / 1
| 1
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"Together, these results demonstrate that miR-30 directly targets the ERG 3 ' UTR, thereby reducing TMPRSS2-ERG expression."
Erg11 fragments affects KCNH7
| 1
KCNH7 binds erg11 fragments. 1 / 1
| 1
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"Southern analysis of L. maculans chromosomal DNA revealed binding of erg3 and erg11 fragments to the largest chromosomal DNA bands sized 4.2, 3.6 and 3.2 Mb in isolate M1, and 3.6, 3.6 and 2.9 Mb in isolate C13."
Dioxygen affects KCNH7
| 1
| 1
reach
"Our genetic inactivation experiment of the oxygen dependent ergosterol biosynthetic genes in C. albicans (ERG1, ERG3, and ERG11) underlined an essential role of the C-5 sterol desaturase Erg3 for hypoxic growth (XREF_FIG)."
XII a AT-sterol-5-desaturase affects KCNH7
| 1
XII a AT-sterol-5-desaturase activates KCNH7. 1 / 1
| 1
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"These enzymes are indicated in Fig. 2 and are : (i) from XI to X, a AS-AZ-sterol isomerase (product of ERG2); and (ii) from X to XII a AT-sterol-5-desaturase (product of ERG3), a A22-desa- turase (product of ERG5) and a A24-reductase (product of ERG4) [15,25]."
SrbA affects KCNH7
| 1
SrbA activates KCNH7. 1 / 1
| 1
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"Chromatin immunoprecipitation sequencing (ChIP-seq) analysis of SrbA in A.fumigatus, combined with the expression pattern of ergosterol biosynthesis genes for N.crassa (XREF_FIG), supports the hypothesis that SAH-2 directly regulates erg-1, erg-3, erg-5, erg-11, and erg-25 and that the increased expression of these direct target genes is a good indicator of SAH-2 activation."
SKN7 affects KCNH7
| 1
SKN7 activates KCNH7. 1 / 1
| 1
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"The induction of HSP42 in the erg3 mutant is completely abrogated by SAGA mutations, and the erg3 dependent increase was reduced by ~ 50% by deletion of the transcription factors PDR1 or SKN7, but unaffected by deletion of HAP1 and even increased by deletion of UPC2."
SAH-2 affects KCNH7
| 1
SAH-2 activates KCNH7. 1 / 1
| 1
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"Chromatin immunoprecipitation sequencing (ChIP-seq) analysis of SrbA in A.fumigatus, combined with the expression pattern of ergosterol biosynthesis genes for N.crassa (XREF_FIG), supports the hypothesis that SAH-2 directly regulates erg-1, erg-3, erg-5, erg-11, and erg-25 and that the increased expression of these direct target genes is a good indicator of SAH-2 activation."
Rg3 affects KCNH7
| 1
Rg3 inhibits KCNH7. 1 / 1
| 1
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"Rg3 also induced slowing of ERG1, ERG3, and ELK1 channel deactivation and accelerated the rate of EAG1 channel activation."
RPD3 affects KCNH7
| 1
RPD3 activates KCNH7. 1 / 1
| 1
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"Homozygous deletion of RPD3 or HDA1 did not reduce erg3 mediated azole resistance, nor did combined deletion of HOS2, RPD3, and HDA1 (XREF_FIG), suggesting that there is additional functional redundancy in the KDACs governing azole resistance in C. albicans."
OenB affects KCNH7
| 1
OenB activates KCNH7. 1 / 1
| 1
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"The C-5 sterol desaturase (ERG3) gene was down-regulated in Paracoccidioides yeast treated with OenB for 90min."
NADPH affects KCNH7
| 1
NADPH inhibits KCNH7. 1 / 1
| 1
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"Like other iron containing enzymes in the ER, Erg3 is reduced by NADPH via Ncp1 and Cyb5."
MOGS affects KCNH7
| 1
| 1
sparser
"Since Glo3 and Gcs1 have partially overlapping functions ( xref ), we tested next whether GCS1 would interact genetically with ERG3 ."
Lovastatin affects KCNH7
| 1
Lovastatin increases the amount of KCNH7. 1 / 1
| 1
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"Lovastatin treatment enhanced the expression of ergosterol biosynthetic genes, ERG2 and ERG3 in wild-type and upc2BDelta but not in upc2ADelta cells."
| 1
sparser
"While cells transfected with reporter construct by itself showed baseline luciferase activity, co-transfection with either the wtERG3 or TMPRSS2-ERG3 activated the transcription mediated by the mef2c reporter."
KCNH7 affects tomatidine
| 1
Mutated KCNH7 activates tomatidine. 1 / 1
| 1
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"However, erg6 and erg3 mutants (but not erg2 mutants) have enhanced resistance to tomatidine, suggesting a complex interaction of erg mutations, sterol content, and tomatidine resistance."
| 1
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"Given the number of adventitious synonymous SNPs discovered in our test strain (and in yFS101, below), it seemed unlikely that the erg3 + synonymous SNP caused the TMS phenotype in yDA317."
KCNH7 affects sterol C5,6-desaturase
| 1
Mutated KCNH7 activates sterol C5,6-desaturase. 1 / 1
| 1
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"This study demonstrates that an ERG3 mutation causing inactivation of sterol C5,6-desaturase can not confer fluconazole resistance in vivo by itself regardless of resistance measured by standard in vitro testing."
| 1
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"Although sterol composition analyses of Hyb-8 and its parental strains are needed, the enhanced expression of ERG25 and ERG3 may contribute to the high fermentation ability of Hyb-8 by maintaining cell membrane homeostasis under microaerobic and multiple stress conditions."
KCNH7 affects gacH
| 1
KCNH7 increases the amount of gacH. 1 / 1
| 1
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"TGF-beta also induces Egr-3 by canonical Smad3 signaling, and Erg-3 overexpression stimulates CI gene expression."
KCNH7 affects erg11 fragments
| 1
KCNH7 binds erg11 fragments. 1 / 1
| 1
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"Southern analysis of L. maculans chromosomal DNA revealed binding of erg3 and erg11 fragments to the largest chromosomal DNA bands sized 4.2, 3.6 and 3.2 Mb in isolate M1, and 3.6, 3.6 and 2.9 Mb in isolate C13."
KCNH7 affects TK-CAT gene
| 1
KCNH7 increases the amount of TK-CAT gene. 1 / 1
| 1
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"Erg-3 was also found to activate the transcription of the reporter TK-CAT gene linked to erg target sequences suggesting that erg-3 codes for a sequence specific transcriptional activator."
KCNH7 affects NOL3
| 1
KCNH7 increases the amount of NOL3. 1 / 1
| 1
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"BDNF has been shown to regulate ERG3 through activation of the protein kinase C pathway, and ERG3 transcriptional activity induces the expression of ARC, a protein involved in synaptic plasticity and long-term potentiation."
KCNH7 affects MOGS
| 1
| 1
sparser
"Since Glo3 and Gcs1 have partially overlapping functions ( xref ), we tested next whether GCS1 would interact genetically with ERG3 ."
KCNH7 affects HSP90
| 1
| 1
sparser
"Hsp90 mediated azole resistance is associated with loss of erg3 function, leading to accumulation of ergosta-7,22-dienol in C. albicans ."
KCNH7 affects HSP104 mRNA
| 1
KCNH7 increases the amount of HSP104 mRNA. 1 / 1
| 1
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"In surprising results, we discovered that Rvs167p, which has previously been shown to play a direct role in the internalization step of endocytosis, associates with the SAGA complex, detected only in the erg3 mutant, and is required for the erg3 dependent increase in HSP42 and HSP104 mRNA expression."
KCNH7 affects HSP104
| 1
KCNH7 activates HSP104. 1 / 1
| 1
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"The function of Rvs167p in the nucleus is not an indirect consequence of the block in the endocytic pathway because the rvs161 mutant, which has the same endocytic phenotype as rvs167, did not block the erg3 -- dependent induction of HSP42 and HSP104."
KCNH7 affects ERG28
| 1
Mutated KCNH7 inhibits ERG28. 1 / 1
| 1
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"In the erg3 mutant the SAGA mutations reduce the ERG28 transcripts to wild-type levels, suggesting a particular role of the SAGA complex in regulating gene expression under sterol deficiency."
KCNH7 affects DAN1
| 1
KCNH7 activates DAN1. 1 / 1
| 1
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"To select mutants that are defective in the erg3 dependent induction of DAN1, we mutagenized erg3 ura3 cells harboring the DAN1-URA3 plasmid with ethanemethanesulfonate, allowed the cells to recover from the mutagenesis, and then selected for cells that grew on geneticin containing 5-FOA plates (thus defective for DAN1 induction)."
KCNH7 affects CA1
| 1
KCNH7 activates CA1. 1 / 1
| 1
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"Knockdown of ERG3 channels enhances neuronal intrinsic excitability (caused by decreased fast afterhyperpolarization, shortened delay time to the generation of an action potential and enhanced summation of somatic excitatory post-synaptic potentials) in hippocampal CA1 pyramidal neurons and DG granule cells."
KCNH7 affects C-MYC [
| 1
KCNH7 increases the amount of C-MYC [. 1 / 1
| 1
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"Earlier studies from our laboratory showed that ERG3 binds to the C-MYC P2 promoter downstream elements and activates the expression of C-MYC [XREF_BIBR]."
KCNH7 affects Asp-Gly
| 1
KCNH7 activates Asp-Gly. 1 / 1
| 1
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"Knockdown of ERG3 channels enhances neuronal intrinsic excitability (caused by decreased fast afterhyperpolarization, shortened delay time to the generation of an action potential and enhanced summation of somatic excitatory post-synaptic potentials) in hippocampal CA1 pyramidal neurons and DG granule cells."
KCNH7 affects Ala-Pro
| 1
KCNH7 activates Ala-Pro. 1 / 1
| 1
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"Knock-down of ERG3 channels significantly increases neuronal intrinsic excitability, which is mainly caused by decreased fast afterhyperpolarization (AHP), shortened delay time to the generation of an action potential (AP) and enhanced summation of somatic excitatory post-synaptic potentials (EPSPs)."
KCNH7 affects AS'6-desaturase
| 1
KCNH7 inhibits AS'6-desaturase. 1 / 1
| 1
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"It is a haploid strain containing a gene disrupted sterol 14 ~-demethylase (ACYP51A1; ergll) and a suppressor mutation in sterol AS ' 6-desaturase (erg3) which allows the sterol 14ct-demethylase disruptant to grow aerobically by changing the sterol accumulating to 14 ~-methylfecosterol [4]."
| 1
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"One Erg proteins was found to bind known substrates (e.g. Erg3 bound episterol) and three other Erg proteins bound known products (e.g. (S) -2,3-epoxysqualene for Erg1) suggesting that these substrates and products are tightly associated with their metabolizing and biosynthetic enzymes."
ITZ affects KCNH7
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ITZ increases the amount of KCNH7. 1 / 1
| 1
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"The ERG11 and ERG3 gene expressions were upregulated by ITZ and its combination with LOV, but seemingly not by LOV single treatment after 1.5 and 3h."
HDA19 affects KCNH7
| 1
HDA19 activates KCNH7. 1 / 1
| 1
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"Homozygous deletion of RPD3 or HDA1 did not reduce erg3 mediated azole resistance, nor did combined deletion of HOS2, RPD3, and HDA1 (XREF_FIG), suggesting that there is additional functional redundancy in the KDACs governing azole resistance in C. albicans."
GRB2 affects KCNH7, and SH2B3
| 1
KCNH7 binds SH2B3 and GRB2. 1 / 1
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sparser
"The two input genes, KCNH7 and SH2B3 , interacted with GRB2 , which was highly expressed in islets (data not shown) and is central in the network."
GFM1 affects KCNH7
| 1
GFM1 inhibits KCNH7. 1 / 1
| 1
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"Further study showed that Efg1, but not Cph1, negatively regulated ERG3."
GCA affects IFIH1, and KCNH7
| 1
KCNH7 binds IFIH1 and GCA. 1 / 1
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sparser
"Association of the IFIH1-GCA-KCNH7 chromosomal region with rheumatoid arthritis."
FgERG5 genes affects KCNH7
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FgERG5 genes activates KCNH7. 1 / 1
| 1
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"In addition, complementation of FgERG3 and FgERG5 genes into S. cerevisiae partially rescued the susceptibility of S. cerevisiae ERG3 and ERG5 deletion mutants towards hydroxyurea and caffeine."
FgERG3 affects KCNH7
| 1
FgERG3 activates KCNH7. 1 / 1
| 1
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"In addition, complementation of FgERG3 and FgERG5 genes into S. cerevisiae partially rescued the susceptibility of S. cerevisiae ERG3 and ERG5 deletion mutants towards hydroxyurea and caffeine."
FLC affects KCNH7
| 1
FLC decreases the amount of KCNH7. 1 / 1
| 1
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"The regulation variations included increased mRNA levels of ERG3, ERG6, and ERG11 and decreased mRNA levels of ERG3 and ERG6 in response to FLC."
ERG4 affects ERG6, KCNH6, and KCNH7
| 1
KCNH6 binds KCNH7, ERG4, and ERG6. 1 / 1
| 1
sparser
"Second, Parsons et al . [ xref ] concluded from ERG2 , ERG3 , ERG4 and ERG6 interactions that ergosterol synthesis affects multidrug resistance."
ERG affects KCNH7
| 1
ERG activates KCNH7. 1 / 1
| 1
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"Knockdown of ERG3 channels in hippocampus enhanced seizure susceptibility, while mice treated with ERG channel activator NS-1643 were less prone to epileptogenesis."
CPH1 affects KCNH7
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CPH1 inhibits KCNH7. 1 / 1
| 1
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"Further study showed that Efg1, but not Cph1, negatively regulated ERG3."
ABCG29 affects KCNH7
| 1
ABCG29 activates KCNH7. 1 / 1
| 1
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"The induction of HSP42 in the erg3 mutant is completely abrogated by SAGA mutations, and the erg3 dependent increase was reduced by ~ 50% by deletion of the transcription factors PDR1 or SKN7, but unaffected by deletion of HAP1 and even increased by deletion of UPC2."
A22-desa- turase affects KCNH7
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A22-desa- turase activates KCNH7. 1 / 1
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"These enzymes are indicated in Fig. 2 and are : (i) from XI to X, a AS-AZ-sterol isomerase (product of ERG2); and (ii) from X to XII a AT-sterol-5-desaturase (product of ERG3), a A22-desa- turase (product of ERG5) and a A24-reductase (product of ERG4) [15,25]."
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"One Erg proteins was found to bind known substrates (e.g. Erg3 bound episterol) and three other Erg proteins bound known products (e.g. (S) -2,3-epoxysqualene for Erg1) suggesting that these substrates and products are tightly associated with their metabolizing and biosynthetic enzymes."
1H-pyrrole affects KCNH7
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1H-pyrrole activates mutated KCNH7. 1 / 1
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"As a consequence of the erg3 mutation the sterols of cells not treated with azole also do not contain ergosterol, and this absence of ergosterol provides a mechanism causing cross-resistance to antifungal amphotericin B [41]."