INDRA statements for KCNH4

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
Hsa-miR-335-5p affects KCNH4
1 |
Transcriptionally active hsa-miR-335-5p decreases the amount of KCNH4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18185580
Hsa-miR-26b-5p affects KCNH4
1 |
Transcriptionally active hsa-miR-26b-5p decreases the amount of KCNH4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19088304
Dihydrogen affects KCNH4
| 1
Dihydrogen inhibits KCNH4. 1 / 1
| 1
sparser
"We show here that Kv10.2, Kv12.2, and Kv12.3 are similarly inhibited by external protons, suggesting that high sensitivity to physiological pH changes is a general property of EAG superfamily channels."
23712551
RAMP1 affects KCNH4
| 1
KCNH4 binds RAMP1. 1 / 1
| 1
reach
"In this study, we report an association between KCNH4, ENDOG, RAMP1, and PHKB with LV traits in African Americans from the HyperGEN study."
29503979
PHKB affects KCNH4
| 1
KCNH4 binds PHKB. 1 / 1
| 1
reach
"In this study, we report an association between KCNH4, ENDOG, RAMP1, and PHKB with LV traits in African Americans from the HyperGEN study."
29503979
MAF affects KCNH4
| 1
MAF activates KCNH4. 1 / 1
| 1
reach
"We recognize that the associations of our top genes (KCNH4 and ENDOG) are driven by very rare (MAF < 0.5%) single variants."
29503979
KCNH4 affects anti-GD3 IgG
| 1
KCNH4 activates anti-GD3 IgG. 1 / 1
| 1
reach
"BEC2, an anti-idiotypic monoclonal antibody that mimics GD3, can induce anti-GD3 IgG in rabbits."
9816218
KCNH4 affects RAMP1
| 1
KCNH4 binds RAMP1. 1 / 1
| 1
reach
"In this study, we report an association between KCNH4, ENDOG, RAMP1, and PHKB with LV traits in African Americans from the HyperGEN study."
29503979
KCNH4 affects PHKB
| 1
KCNH4 binds PHKB. 1 / 1
| 1
reach
"In this study, we report an association between KCNH4, ENDOG, RAMP1, and PHKB with LV traits in African Americans from the HyperGEN study."
29503979
KCNH4 affects IgG
| 1
KCNH4 activates IgG. 1 / 1
| 1
reach
"Immunization of rabbits with BEC2 induced IgG against GD3 which was an encouraging observation since rabbits, like humans, express GD3 on some normal tissues.16 371 We have carried out a series of clinical trials exploring the ability of BEC2 to induce anti-GD3 antibodies in melanoma patients."
8938275
KCNH4 affects GD3
| 1
KCNH4 activates GD3. 1 / 1
| 1
reach
"This includes the anti-idiotype vaccine, BEC-2 (administered with BCG adjuvant) targeting GD3 ganglioside, which was tested in a randomized trial as maintenance therapy in patients with limited stage SCLC, but yielded limited antibody responses against GD3 and no improvement in survival or progression-free survival [XREF_BIBR]."
21811785
KCNH4 affects ENDOG
| 1
ENDOG binds KCNH4. 1 / 1
| 1
reach
"In this study, we report an association between KCNH4, ENDOG, RAMP1, and PHKB with LV traits in African Americans from the HyperGEN study."
29503979
KCNH4 affects EGR3
| 1
KCNH4 activates EGR3. 1 / 1
| 1
reach
"In a small pilot study, 15 patients with SCLC were treated with the anti-idiotype BEC2 vaccine, for which the ganglioside antigen GD3 is the target [XREF_BIBR]."
22495056
ENDOG affects KCNH4
| 1
ENDOG binds KCNH4. 1 / 1
| 1
reach
"In this study, we report an association between KCNH4, ENDOG, RAMP1, and PHKB with LV traits in African Americans from the HyperGEN study."
29503979