INDRA statements for KCNG1

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KCNG1 affects NFkappaB
| 35
KCNG1 activates NFkappaB.
| 31
KCNG1 activates NFkappaB. 31 / 31
| 31
sparser
"As another independent test to rule out the involvement of linear Ub chains in K13-induced NF-κB activation, we tested the ability of CYLD to block K13-induced NF-κB-Luc reporter activity."
22590573
sparser
"Our results withHOIL-1 − / − and cpdm MEFs, rule out the requirement of LUBAC-induced linear polyubiquitination in K13-induced NF-κB activation."
22590573
sparser
"We used HOIL-1 -null MEFs to test the involvement of LUBAC-induced linear polyubiquitination in K13-induced NF-κB activation."
22590573
sparser
"The studies in the preceding section clearly demonstrate that TAK1, TRAF6 and linear polyubiquitination of NEMO are not involved in K13-induced NF-κB activation."
22590573
sparser
"HOIL-1 is not Essential for K13-induced NF-κB Activation."
22590573
sparser
"Sharpin is not Essential for K13-induced NF-κB Activation."
22590573
sparser
"Selective NF-kappaB activation by K13 might represent a novel strategy employed by the virus to promote latency."
17597077
sparser
"The lack of requirement of linear polyubiquitination in K13-induced NF-κB activation was further supported by our results showing that CYLD, a deubiquitylating enzyme that can cleave linear ubiquitin chains, cannot block K13-induced NF-κB activity."
22590573
sparser
"K13-induced NF-κB activation has been reported to play an essential role in promoting the survival of latently-infected PEL cells by up-regulating the expression of anti-apoptotic proteins xref ."
17957251
sparser
"In this report, we have excluded the involvement of TRAF6, which has been implicated in NF-κB activation during signaling emanating from IL-1 and Toll like receptors xref , xref , in K13-induced NF-κB activation."
22590573
sparser
"Furthermore, linear polyubiquitination of NEMO is not required for K13-induced NF-κB activation."
22590573
sparser
"Biochemical studies have revealed some insights into the molecular mechanisms that control NF-κB activation by K13 and K15."
27538487
sparser
"Interestingly, a F312A mutation in human NEMO, which corresponds to the F305A mutation in mouse NEMO tested in this study, was shown to be defective in binding to Lys63-linked ubiqutin chains xref , which suggests that K13 activates NF-κB independent of Lys63-linked chains as well."
22590573
sparser
"TRAF6 is not Required for K13-induced NF-κB Activation."
22590573
sparser
"TAK1 is not Required for K13-induced NF-κB Activation."
22590573
sparser
"Taken collectively with previous studies, the above results confirm that TAK1 is not required for K13-induced NF-κB activation."
22590573
sparser
"Furthermore, endogenously expressed TRAF2 and TRAF3 do not interact with K13 and play no role in K13-induced NF-kappaB activation or its interaction with the IKK complex."
17597077
sparser
"Ectopic expression of K13 failed to induce nuclear p65/RelA DNA binding activity in theNEMO −/Y MEFs reconstituted with an empty vector, but resulted in approximately 3 fold increase in the nuclear p65/RelA DNA binding activity in those reconstituted with the wild-type NEMO, thereby confirming that NEMO is required for K13-induced NF-κB activation ( xref )."
22590573
sparser
"As shown in xref , treatment with 4OHT resulted in equivalent upregulation of A20 in theTRAF6 +/+ andTRAF6 −/− ,which argues against the involvement of TRAF6 in K13-induced NF-κB activation."
22590573
sparser
"Based on the lack of involvement of TRAF6, TAK1 and LUBAC in K13-induced NF-κB activation, we support a model according to which the interaction between K13 and NEMO is direct and is not mediated via the TRAF family members or the linear ubiquitin chains."
22590573
sparser
"The stimulatory effect of 4OHT on G 1 to S phase transition was blocked by treatment with Bay-11-7082, thereby confirming the role of K13-induced NF-κB activation in this process ( xref )."
22624040
sparser
"Despite this fact, alteration of these residues in K13 results in a mutant K13 that no longer activates NF-κB ( xref )."
22301546
sparser
"To study the role of TAK1 in K13-induced NF-κB activation, we took advantage of murine embryonic fibroblast (MEFs) cells deficient in this protein."
22590573
sparser
"In this study, we have investigated the role of TRAF6, TAK1 and LUBAC in K13-induced NF-κB activation."
22590573
sparser
"To confirm the lack of involvement of linear polyubiquitination in K13-induced NF-κB activation, we took advantage of cells that are deficient in two essential components of LUBAC, an enzyme complex required for linear polyubiquitination."
22590573
sparser
"The K13-TRAF2 interaction is believed to be essential for the recruitment of K13 to the I-kappaB kinase (IKK) complex and for K13-induced NF-kappaB and JNK activation."
17597077
sparser
"In addition, TRAF3 has been reported to be required for K13-induced NF-kappaB and JNK activation."
17597077
sparser
"Thus, K13 activates NF-κB via a mechanism distinct from that utilized by inflammatory cytokines."
22590573
sparser
"Selective inhibitors of the IKK1 kinase activity may have a role in the treatment of disorders caused by abnormal NF-kappaB activation by HHV8 vFLIP K13."
14561765
sparser
"Thus, binding of NEMO to linear polyubiquitin chain is not required for K13-induced NF-κB activation."
22590573
sparser
"Therefore, we believe that rather than blocking NF-κB pathway globally, the ideal agent for the treatment of KSHV-associated lymphoproliferative disorders should selectively block K13-induced NF-κB activation."
22590573
KCNG1 binds NFkappaB.
| 4
NFkappaB binds KCNG1 and tat. 1 / 1
| 1
sparser
"We hypothesized that a functional interaction between K13-induced NF-κB and Tat may be particularly important in the early stages of HIV-1 infection when the amount of Tat is limited."
15713234
NFkappaB binds KCNG1 and cytokine. 1 / 1
| 1
sparser
"K13 is a powerful activator of the NF-κB pathway and others and we have previously reported that K13-induced upregulation of proinflammatory cytokines in vascular endothelium cells is associated with NF-κB activation and can be blocked by genetic and pharmacological inhibitors of this pathway [ xref , xref ]."
19660139
IKK_complex binds JNK, NFkappaB, and KCNG1. 1 / 1
| 1
sparser
"Our results support a model in which K13 bypasses the upstream components of the tumor necrosis factor receptor signaling pathway and directly interacts with the IKK complex to selectively activate the NF-kappaB pathway without affecting the JNK pathway."
17597077
NFkappaB binds CHUK, IKBKB, and KCNG1. 1 / 1
| 1
sparser
"KSHV protein K13 interacts with the IKKa-IKKb complex to prevent NF-κB inhibition ( xref )."
27650455
Hyd WA affects KCNG1
| 30
KCNG1 binds hyd WA. 28 / 28
| 28
sparser
"Although K13-propeller mutations previously associated with delayed parasite clearance in Cambodia were not identified, 26 K13-propeller mutations were identified in both recent samples and pre-ACT infections."
25918205
sparser
"Baseline parasitaemia was associated with the K13-propeller mutation ( P value = 0.37 [linear regression, adjusted for site])."
28086775
sparser
"The increased K13-propeller gene mutations previously associated with DPC among P. falciparum populations from 2013 to 2014 in Grande Comore (a ~20 % increment) may present new challenges in the ACT efficacy in the future [ xref , xref ]."
27527604
sparser
"Although wide-scale studies that analyzed P . falciparum isolates from numerous sub-Saharan African countries including Ethiopia found no mutations in the parasite’s K13-propeller gene, which is associated with artemisinin resistance in Southeast Asia [ xref , xref ] the threat is clear."
28445503
sparser
"It has been suggested that Y493H, I543T, R539T, and C580Y mutations in K13-propeller gene are associated with prolonged parasite survival ex vivo; Y493H, R539T, and C580Y mutations are linked to in vivo delayed parasite clearance; and M476I mutation is related to artemisinin tolerance in vitro [ xref , xref , xref , xref ] ."
26667053
sparser
"In GrpA, artemisinin resistance and K13-propeller polymorphisms also associated with down-regulation of genes involved in DNA replication ( xref and xref )."
25502316
sparser
"F32-DU whole genome sequencing (WGS) revealed that resistance to trioxaquine was associated with the same non-synonymous mutation in the propeller domain of the K13 protein (M476I) that was found in the F32-ART lineage."
29177421
sparser
"We found low prevalence of K13 propeller domain mutations, which are associated with artemisinin resistance in Asia, but one mutation previously identified in northern Uganda, 675V, was seen in 2.0% of samples, including 5.5% from the 3 northernmost sites."
30559133
sparser
"In addition, mutations in the P. falciparum K13 gene (PF3D7_1343700) that encodes the kelch propeller domain were associated with in vitro resistance to artemisinin and with delayed clearance after artemisinin treatment in southern Asia [ xref , xref , xref ]."
25849097
sparser
"Our observation is consistent with those in previous reports from Kenya [ xref ], Angola [ xref ], Mozambique [ xref ], Senegal [ xref ], Ugandan [ xref ] as well as other areas of Sub-Saharan Africa [ xref ], Caribbean’s Haiti [ xref ], and South Asia’ Bangladesh [ xref ], where the K13-propeller gene mutations associated with artemisinin resistance were absent."
26667053
sparser
"Furthermore, molecular surveillance in Dakar has demonstrated the emergence of polymorphisms in the K13 propeller domain gene, which is associated with in vitro and in vivo resistance to artemisinin in Asia [ xref – xref ]."
27387549
sparser
"These observations suggest that not all K13-propeller mutations are associated with artemisinin resistance, and that secondary loci are involved in resistance Asian parasites, but not in African parasites."
26667053
sparser
"Numerous independent K13 propeller mutations associated with resistance have emerged independently across the region ( xref , xref ), and the frequencies of some mutations, notably, Cys580Tyr, have risen in multiple geographical areas."
28137815
sparser
"Meanwhile, artemisinin tolerance in vitro was associated with the M476I mutation of K13-propeller [ xref ]."
26667053
sparser
"The role of the A578S amino acid substitution is unclear, but it occurs near the most common K13-propeller mutation (C580Y), which has been associated with delayed parasite clearance in Southeast Asia and with tolerance to artemisinin in vitro ( xref )."
26079933
sparser
"Recently association of K13-propeller polymorphism with artemisinin resistance in vitro and in vivo has been proposed [ xref ]."
25052385
sparser
"Both transcriptional phenotypes are closely associated with K13-propeller polymorphism, and may enable parasites to survive artemisinin by repairing and replenishing their oxidatively-damaged proteins before advancing through the cell cycle."
27337450
sparser
"Mutations in the P. falciparum k13 gene that encodes the kelch propeller domain were associated with in vitro resistance to artemisinin and with delayed clearance after artemisinin treatment in Southeast Asia [ xref , xref – xref ]."
25471113
sparser
"It needs to be confirmed whether parasites harbouring both K13 mutation and pfmdr1 multiple copies and/or the observed new mutations of K13 propeller domain are associated with clinical artemisinin resistance."
31239407
sparser
"The presence of K13 propeller mutations within Africa, where parasite clearance is generally rapid, suggests that not all K13 propeller mutations are associated with resistance, that secondary loci are involved in resistance and found in Asia but not in Africa thus far, or that the resistance phenotype is masked by high levels of antimalarial immunity."
25891142
sparser
"The K13-propeller mutations associated with artemisinin-resistance were mainly found in Southeast Asia, with C580Y being the predominant one."
28797235
sparser
"The sensitivity and specificity of this definition may be enhanced by using only the subset of K13 -propeller mutations that have been associated with artemisinin resistance in clinical and in vitro studies, or combining them with other molecular markers."
27776514
sparser
"Interestingly, a cluster of seven mutants were identified that were sensitive to artemisinin, including one with a mutation in the K13-propeller gene that is associated with resistance xref , xref , xref ."
27803804
sparser
"A mutant K13 propeller domain has now been associated with artemisinin resistance in Cambodia and in the Greater Mekong Region ( xref – xref , xref , xref )."
26401601
sparser
"Genomic analysis of Cambodian parasite isolates have identified four prevalent K13-propeller mutations (Y493H, R539T, I543T, and C580Y) that are associated with elevated ring-stage survival rates In vitro and long parasite clearance half-lives (>5 h) [ xref ]."
27543172
sparser
"Specifically, three mutations (C580Y, R539T and Y493H) in the K13-propeller gene were strongly associated with increased ring stage survival and delayed parasite clearance [ xref ]."
26667053
sparser
"Major mutations in the K13 propeller domain associated with artemisinin resistance in the Mekong region (C580Y, R539T and Y493H) were absent, but F446I and two previously undescribed mutations (V603E and V454I) were identified."
30883571
sparser
"Based on Keap1 function, a hypothetical model could be that in steady state conditions, the wild-type K13-propeller domain binds to uTF (a putative, unidentified transcription factor functionally equivalent to human Nrf2) allowing its ubiquitination and proteosomal degradation."
26955948
AGRP binds KCNG1 and hyd WA. 1 / 1
| 1
sparser
"Importantly, K13-propeller mutations more accurately identify slow-clearing parasites than KH group ( xref ), demonstrating that the association of K13-propeller polymorphism with clinical ART resistance in Cambodia is partially independent of the genetic background of KH subpopulations."
24352242
GNL3 binds KCNG1 and hyd WA. 1 / 1
| 1
sparser
"As per the published literature, k13 NS propeller region mutations are not always associated with artemisinin resistance."
27912758
KCNG1 affects IKBKG
| 12
IKBKG binds KCNG1. 9 / 9
| 9
sparser
"However, the exact mechanism by which K13-NEMO interaction results in the activation of the IKK complex and the NF-κB pathway is not clear."
22590573
sparser
"We and others have previously demonstrated that K13 interacts with NEMO and NEMO is essential for K13-induced NF-κB activation xref , xref ."
22590573
sparser
"We further demonstrate that binding of K13 to NEMO is required for recruitment of IKK1 and IKK2 to K13."
22590573
sparser
"In a recent study, we demonstrated that TRAF2, which is required for NF-κB activation by TNFα, is not required for the interaction of K13 with NEMO and for K13-induced NF-κB activation xref ."
22590573
sparser
"However, it is not clear how K13-NEMO interaction results in the activation of the IKK complex."
22590573
sparser
"Based on the lack of involvement of TRAF6, TAK1 and LUBAC in K13-induced NF-κB activation, we support a model according to which the interaction between K13 and NEMO is direct and is not mediated via the TRAF family members or the linear ubiquitin chains."
22590573
sparser
"We next asked the question how the interaction of K13 with NEMO results in the activation of the IKK complex and the NF-κB pathway."
22590573
sparser
"Taken collectively, the above results support the model according to which binding of K13 to NEMO manipulates the latter into an open conformation that facilitates the recruitment of IKK1 and IKK2 and their subsequent activation by “T loop” phosphorylation."
22590573
sparser
"However, it has remained enigmatic how K13-NEMO interaction results in the activation of the IKK complex."
22590573
CHUK binds IKBKB, IKBKG, and KCNG1. 2 / 2
| 2
sparser
"We next examined if recruitment of IKK1 and IKK2 to the K13-NEMO complex is also associated with “T Loop” phosphorylation of IKK1, IKK2 or both."
22590573
sparser
"As shown in xref , while interaction of K13 with NEMO, IKK1, and IKK2 was readily detected in samples immunoprecipitated with Flag antibody from wild-type Jurkat cells, no significant interaction between K13 and IKK1 or IKK2 was observed in the NEMO-deficient Jurkat cells, Stimulation of cells with TNFα or IL-1 induces recruitment of IKK1 and IKK2 to NEMO and their subsequent phosphorylation and activation xref , xref ."
22590573
HSP90 binds IKBKG and KCNG1. 1 / 1
| 1
sparser
"K13 interacts with HSP90 via NEMO."
23881928
KCNG1 affects IKK_complex
| 10
KCNG1 binds IKK_complex.
| 9
IKK_complex binds KCNG1. 8 / 8
| 8
sparser
"Essential Role of NEMO in Mediating K13-IKK Interaction and IKK Activation."
22590573
sparser
"BIIB021 also blocked constitutive NF-κB activity present in PEL cells in part by blocking the interaction of vFLIP K13 with the IKK complex subunits."
23881928
sparser
"HSP90 inhibitors disrupt the interaction between K13 and the IKK complex."
23881928
sparser
"Most importantly, BIIB021 blocked the activity of K13, which was associated with a disruption of the K13-IKK complex."
23881928
sparser
"KSHV-encoded viral FLICE-inhibitory protein (vFLIP) K13 binds to the IkappaB kinase (IKK) complex to constitutively activate the NF-κB pathway, which has been shown to be essential for the survival and proliferation of PEL cells."
23881928
sparser
"To understand the mechanism by which HSP90 inhibitors block K13-induced NF-κB, we examined their effect on K13-IKK complex interaction in 293-pSLIK-TO-K13/NF-κB-Luc cells using a co-immunoprecipitation (co-IP) assay."
23881928
sparser
"NEMO is essential for the interaction of K13 with the IKK complex ( xref , xref )."
23881928
sparser
"Thus, HSP90 activity is required for the assembly of the K13-IKK complex and BIIB021 blocks K13-induced NF-κB activity by disrupting this complex."
23881928
IKK_complex binds JNK, NFkappaB, and KCNG1. 1 / 1
| 1
sparser
"Our results support a model in which K13 bypasses the upstream components of the tumor necrosis factor receptor signaling pathway and directly interacts with the IKK complex to selectively activate the NF-kappaB pathway without affecting the JNK pathway."
17597077
KCNG1 activates IKK_complex.
| 1
KCNG1 activates IKK_complex. 1 / 1
| 1
sparser
"Activation of the IKK complex by K13 results in phosphorylation of IκB proteins which leads to their ubiquitination and proteasomal-mediated degradation, allowing the classical NF-κB subunits to enter the nucleus and turn on the expression of their target genes xref ."
22624040
IKK_complex affects KCNG1
| 9
IKK_complex binds KCNG1. 8 / 8
| 8
sparser
"Essential Role of NEMO in Mediating K13-IKK Interaction and IKK Activation."
22590573
sparser
"BIIB021 also blocked constitutive NF-κB activity present in PEL cells in part by blocking the interaction of vFLIP K13 with the IKK complex subunits."
23881928
sparser
"HSP90 inhibitors disrupt the interaction between K13 and the IKK complex."
23881928
sparser
"Most importantly, BIIB021 blocked the activity of K13, which was associated with a disruption of the K13-IKK complex."
23881928
sparser
"KSHV-encoded viral FLICE-inhibitory protein (vFLIP) K13 binds to the IkappaB kinase (IKK) complex to constitutively activate the NF-κB pathway, which has been shown to be essential for the survival and proliferation of PEL cells."
23881928
sparser
"To understand the mechanism by which HSP90 inhibitors block K13-induced NF-κB, we examined their effect on K13-IKK complex interaction in 293-pSLIK-TO-K13/NF-κB-Luc cells using a co-immunoprecipitation (co-IP) assay."
23881928
sparser
"NEMO is essential for the interaction of K13 with the IKK complex ( xref , xref )."
23881928
sparser
"Thus, HSP90 activity is required for the assembly of the K13-IKK complex and BIIB021 blocks K13-induced NF-κB activity by disrupting this complex."
23881928
IKK_complex binds JNK, NFkappaB, and KCNG1. 1 / 1
| 1
sparser
"Our results support a model in which K13 bypasses the upstream components of the tumor necrosis factor receptor signaling pathway and directly interacts with the IKK complex to selectively activate the NF-kappaB pathway without affecting the JNK pathway."
17597077
KCNG1 affects AGRP
| 7
AGRP binds KCNG1. 6 / 6
| 6
sparser
"ART resistance has been associated with mutations in k13 [ xref , xref , xref , xref ]."
31822269
sparser
"K13 mutations associated with ART resistance were mainly detected in areas of the GMS [ xref , xref - xref ], with C580Y being the predominant."
25927592
sparser
"The other codon mutations in k13 are reportedly associated with ART resistance."
29843734
sparser
"ART resistance has been associated with mutant forms of the Kelch protein K13, first identified via in vitro DHA resistance selection and whole-genome sequencing of patient samples xref ."
30115924
sparser
"Surveys conducted in different regions showed that K13 mutations associated with ART resistance were restricted to certain areas of the GMS, including Cambodia, Thailand, Myanmar, and Vietnam."
25927592
sparser
"In this study, the polymorphisms of K13 genes in parasite populations along the China-Myanmar border were investigated, and the presence of K13 mutations that are associated with clinical ART resistance in this region was demonstrated using longitudinally archived parasite samples."
25927592
AGRP binds KCNG1 and hyd WA. 1 / 1
| 1
sparser
"Importantly, K13-propeller mutations more accurately identify slow-clearing parasites than KH group ( xref ), demonstrating that the association of K13-propeller polymorphism with clinical ART resistance in Cambodia is partially independent of the genetic background of KH subpopulations."
24352242
NFkappaB affects KCNG1
| 6
NFkappaB binds KCNG1.
| 4
NFkappaB binds KCNG1 and tat. 1 / 1
| 1
sparser
"We hypothesized that a functional interaction between K13-induced NF-κB and Tat may be particularly important in the early stages of HIV-1 infection when the amount of Tat is limited."
15713234
NFkappaB binds KCNG1 and cytokine. 1 / 1
| 1
sparser
"K13 is a powerful activator of the NF-κB pathway and others and we have previously reported that K13-induced upregulation of proinflammatory cytokines in vascular endothelium cells is associated with NF-κB activation and can be blocked by genetic and pharmacological inhibitors of this pathway [ xref , xref ]."
19660139
IKK_complex binds JNK, NFkappaB, and KCNG1. 1 / 1
| 1
sparser
"Our results support a model in which K13 bypasses the upstream components of the tumor necrosis factor receptor signaling pathway and directly interacts with the IKK complex to selectively activate the NF-kappaB pathway without affecting the JNK pathway."
17597077
NFkappaB binds CHUK, IKBKB, and KCNG1. 1 / 1
| 1
sparser
"KSHV protein K13 interacts with the IKKa-IKKb complex to prevent NF-κB inhibition ( xref )."
27650455
NFkappaB activates KCNG1.
| 2
NFkappaB activates KCNG1. 2 / 2
| 2
sparser
"K13 most likely promoted NF-κB activation by direct or indirect physical recruitment of MALT1, as K13 interacted with MALT1 but not with BCL10 upon co-expression of the proteins in 293 T cells ( xref )."
27538487
sparser
"Furthermore, our approach confirmed K10.5 as an NF-kappaB inhibitor and newly identified K1 as an inhibitor of both K13- and ORF75-mediated NF-kappaB activation."
19129458
KCNG1 affects RNA binding
| 6
KCNG1 activates RNA binding.
| 4
KCNG1 activates RNA binding. 4 / 4
| 4
reach
"Chemical shift perturbation data confirm that RNA binding is mediated by the canonical RNA binding grooves of KH2 and KH3."
20385598
reach
"These data suggest that loss of FMRP function, particularly in KH2 mediated RNA binding and in synaptic plasticity, play critical roles in pathogenesis of the Fragile X Syndrome and establish a new model for studying the disorder."
20011099
reach
"Supporting this hypothesis, a missense mutation (I304N), known to alter the KH2 mediated RNA binding properties of FMRP, abolishes the localization of human FMRP ISO6 to Cajal bodies."
24204304
reach
"The I304N mutation causes defective KH2 mediated RNA binding in neurons, and decreased FMRP levels, particularly in younger animals."
20011099
KCNG1 inhibits RNA binding.
| 2
KCNG1 inhibits RNA binding. 1 / 1
| 1
reach
"The conserved hydrophobic residue implicated in the development of fragile X mental retardation makes an aliphatic stacking interaction with the Ade of 5 '-Ura-Cyt-Ade-Y-3 ', suggesting that the FMR1 protein deficiency phenotype is caused by impairment of RNA binding by KH2 of FMR1."
10676814
KCNG1-G319D inhibits RNA binding. 1 / 1
| 1
reach
"Our results also lend support to earlier mutational data which showed that RNA binding was abolished by mutating the first glycine in the conserved GXXG motifs of KH1 (G253D) and KH2 (G319D)."
21742261
KCNG1 affects MAP3K7
| 6
KCNG1 phosphorylates MAP3K7. 4 / 4
| 4
sparser
"Thus, in contrast to HTLV-1 oncoprotein Tax, K13 does not induce TAK1 phosphorylation."
22590573
sparser
"K13 does not Induce TAK1 Phosphorylation."
22590573
sparser
"K13 does not Induce TAK1 Phosphorylation."
22590573
sparser
"Thus, in contrast to HTLV-1 oncoprotein Tax, K13 does not induce TAK1 phosphorylation."
22590573
KCNG1 phosphorylates MAP3K7 on T187. 2 / 2
| 2
sparser
"Therefore, to examine whether K13 would similarly induce TAK1 Thr-187 phosphorylation, we used retroviral-mediated gene transfer and generated polyclonal populations of two lymphoma cell lines, BCBL1 and Namalwa, expressing an empty vector and FLAG-K13."
22590573
sparser
"Therefore, to examine whether K13 would similarly induce TAK1 Thr-187 phosphorylation, we used retroviral-mediated gene transfer and generated polyclonal populations of two lymphoma cell lines, BCBL1 and Namalwa, expressing an empty vector and FLAG-K13."
22590573
KCNG1 affects KH3
| 6
KCNG1 binds KH3.
| 3
KCNG1 binds KH3. 3 / 3
| 3
reach
"We found that the KH2 can interact with both KH1 and KH3, and KH3 alone can activate the reporter gene expression in yeast cells (XREF_SUPPLEMENTARY)."
23874224
reach
"NMR CSP data obtained titrating 15 N labelled KH23 with the TNFalpha 12mer (XREF_FIG A) revealed not only that both KH2 and KH3 bind RNA using the ' classical ' nucleic acid binding grooves (XREF_FIG B), but also that KH2- and KH3 binding surfaces do not coalesce."
20385598
reach
"Our data indicate that an interaction between KH2 and KH3 is taking place in which the linker plays a pivotal role."
20385598
KCNG1 activates KH3.
| 2
KCNG1-G114A activates KH3. 1 / 1
| 1
reach
"Amino acid substitution mutations of G30A, KH2 G114A and G296A in GXXG motif of KH domain were produced to break KH1, KH2 and KH3 of PCBP1, respectively [XREF_BIBR]."
30086790
KCNG1-G296A activates KH3. 1 / 1
| 1
reach
"Amino acid substitution mutations of G30A, KH2 G114A and G296A in GXXG motif of KH domain were produced to break KH1, KH2 and KH3 of PCBP1, respectively [XREF_BIBR]."
30086790
KCNG1 inhibits KH3.
| 1
KCNG1 inhibits KH3. 1 / 1
| 1
reach
"The deletion analysis showing in the XREF_FIG also raised a possibility of intramolecular interactions within SHI1 because KH2 inhibits the interactions of KH1 and KH3 with FRY2 and CPL1."
23874224
PI3K affects KCNG1
| 5
PI3K binds KCNG1. 5 / 5
| 5
sparser
"Their model of artemisinin mode of action ( xref ) proposes that the interaction between wild-type K13 and PI3K targets the latter for proteosomal degradation."
27337450
sparser
"A prior report associated ART resistance with elevated PI3P levels, mediated by an interaction between K13 and PI3K. The rise in PI3P levels in mutant parasites was attributed to reduced binding of K13 to PI3K, resulting in attenuated ubiquitin-mediated degradation of the kinase [ xref ]."
32310999
sparser
"A prior report associated ART resistance with elevated PI3P levels, mediated by an interaction between K13 and PI3K. The rise in PI3P levels in mutant parasites was attributed to reduced binding of K13 to PI3K, resulting in attenuated ubiquitin-mediated degradation of the kinase [ xref ]."
32310999
sparser
"K13 could similarly associate with PI3K and promote its degradation."
28688800
sparser
"In ART-resistant parasites harboring mutations in the K13 propeller domains, K13 cannot bind and target PI3K for proteasome-mediated degradation."
28688800
KCNG1 affects NPPA
| 5
KCNG1 binds NPPA.
| 4
KCNG1 binds NPPA. 4 / 4
| 4
sparser
"If v-rel proteins do interact with proteins of the NF-K13 complex in vivo, they may disturb an equilibrium between I KB, the NF-KB subunits (p50 and p65), and the full-length precursor of NF-KB p50."
2203533
sparser
"Consequently, it has been hypothesized that either the heat shock tran scription factor HSF regulates HIV -1 transcription through its binding to KB sites or the heat shock treat ment activates NF-K13 binding to DNA [14]."
7811329
sparser
"Direct Interaction between MAD-3 and NF-KB (A) DOC releases NF-K13 DNA- binding activity from the MAD-3 inhibition."
1829648
sparser
"It is tempting to speculate that similar chromatin disruption may lie at the heart of other cooperative interactions involving NF-K13."
9570137
KCNG1 activates NPPA.
| 1
KCNG1 activates NPPA. 1 / 1
| 1
sparser
"Taken collectively, the above results demonstrate that although K13 activates the NF-??"
22624040
NPPA affects KCNG1
| 4
KCNG1 binds NPPA. 4 / 4
| 4
sparser
"If v-rel proteins do interact with proteins of the NF-K13 complex in vivo, they may disturb an equilibrium between I KB, the NF-KB subunits (p50 and p65), and the full-length precursor of NF-KB p50."
2203533
sparser
"Consequently, it has been hypothesized that either the heat shock tran scription factor HSF regulates HIV -1 transcription through its binding to KB sites or the heat shock treat ment activates NF-K13 binding to DNA [14]."
7811329
sparser
"Direct Interaction between MAD-3 and NF-KB (A) DOC releases NF-K13 DNA- binding activity from the MAD-3 inhibition."
1829648
sparser
"It is tempting to speculate that similar chromatin disruption may lie at the heart of other cooperative interactions involving NF-K13."
9570137
KCNG1 affects vFLIP
| 4
KCNG1 activates vFLIP. 4 / 4
| 4
sparser
"In order to determine the contribution of the classical vs alternate NF-κB pathway to vFLIP K13-induced HIV-1 LTR activation, we used a supershift assay to analyze the nature of the protein complexes bound to HIV-1 LTR from nuclear extracts of vFLIP K13-expressing cells."
15713234
sparser
"As shown in Fig. xref , vFLIP K13-induced HIV-1 LTR reporter activation was effectively blocked by MG132, lactacystin and arsenic acid."
15713234
sparser
"Collectively, the above results suggested the involvement of the NF-κB pathway in vFLIP K13-induced HIV-1 LTR activation."
15713234
sparser
"Next we sought to determine whether pharmacological inhibitors of the NF-κB pathway may be used to block vFLIP K13-induced HIV-1 LTR reporter activation."
15713234
KCNG1 affects replication
| 4
KCNG1 inhibits replication.
| 3
KCNG1 inhibits replication. 3 / 3
| 3
sparser
"To rule out the possibility that the inhibition of lytic replication by K13 in the previous studies was an artifact of K13 over-expression, we examined whether silencing of endogenous K13 expression by RNA interference will induce lytic gene expression in PEL cells."
17957251
sparser
"Role of the NF-κB pathway in the inhibition of lytic replication by K13."
17957251
sparser
"To confirm the above results and to examine the role of the NF-κB pathway in the K13-induced inhibition of lytic replication, we generated stable clones of BCBL1-TREx-RTA cells expressing Flag-tagged wild-type K13 (i.e. without fusion with ER TAM ) and its two NF-κB-defective mutants, K13-58AAA and K13-67AAA, respectively xref ."
17957251
KCNG1 activates replication.
| 1
KCNG1 activates replication. 1 / 1
| 1
sparser
"As shown in Figure xref , co-expression of Murr1 led to significant block in K13-induced HIV-1 LTR reporter activity, thereby suggesting that K13-induced activation of HIV-1 replication in resting lymphoid cells may be regulated by Murr1 and K13 may selectively activate HIV-1 replication in activated cells in which expression of Murr1 is known to be down-regulated [ xref ]."
15713234
KCNG1 affects ORF71
| 4
KCNG1 activates ORF71. 4 / 4
| 4
sparser
"In order to determine the contribution of the classical vs alternate NF-κB pathway to vFLIP K13-induced HIV-1 LTR activation, we used a supershift assay to analyze the nature of the protein complexes bound to HIV-1 LTR from nuclear extracts of vFLIP K13-expressing cells."
15713234
sparser
"Next we sought to determine whether pharmacological inhibitors of the NF-κB pathway may be used to block vFLIP K13-induced HIV-1 LTR reporter activation."
15713234
sparser
"Collectively, the above results suggested the involvement of the NF-κB pathway in vFLIP K13-induced HIV-1 LTR activation."
15713234
sparser
"As shown in Fig. xref , vFLIP K13-induced HIV-1 LTR reporter activation was effectively blocked by MG132, lactacystin and arsenic acid."
15713234
KCNG1 affects MALT1
| 4
KCNG1 binds MALT1.
| 3
KCNG1 binds MALT1. 2 / 2
| 2
sparser
"K13 directly or indirectly interacted with MALT1 and in particular its protease domain, and may thus induce a conformational change in the protease domain that promotes MALT1 activation, for example, by rendering it accessible to monoubiquitination."
27538487
sparser
"K13 most likely promoted NF-κB activation by direct or indirect physical recruitment of MALT1, as K13 interacted with MALT1 but not with BCL10 upon co-expression of the proteins in 293 T cells ( xref )."
27538487
Protease binds KCNG1 and MALT1. 1 / 1
| 1
sparser
"K13 directly interacted with the protease domain of MALT1 and may thus induce an active (or activatable) MALT1 conformation."
29560084
KCNG1 activates MALT1.
| 1
KCNG1 activates MALT1. 1 / 1
| 1
sparser
"Thus, K13 probably activates MALT1 and consequently NF-κB via binding to its protease domain, either directly or via an additional binding partner."
27538487
KCNG1 affects HSP90
| 4
HSP90 binds KCNG1. 2 / 2
| 2
sparser
"Thus, NEMO is essential for the interaction of K13 with HSP90."
23881928
sparser
"To check whether NEMO is required for the interaction of K13 with HSP90, we used FLAG-tagged K13-expressing wild-type and NEMO-deficient Jurkat cells."
23881928
HSP90 binds DLST and KCNG1. 1 / 1
| 1
sparser
"While we readily detected an interaction between K13 and HSP90 in the wild-type Jurkat cells using the co-IP assay, we failed to observe this interaction in the NEMO-deficient cells ( xref )."
23881928
HSP90 binds IKBKG and KCNG1. 1 / 1
| 1
sparser
"K13 interacts with HSP90 via NEMO."
23881928
KCNG1 affects DSF
| 4
KCNG1 activates DSF. 4 / 4
| 4
reach
"These results indicated that strain KH2 failed to synthesize branch-chain DSF family signals from carbohydrate metabolism."
29312195
reach
"None of these candidates promoted KH2 production of branched-chain DSF family signals."
29312195
reach
"To determine if branched-chain DSF family signals produced by mutant strain KH2 were from conversion of exogenous BCAAs, we tested DSF family signal production by resting cells of mutant strain KH2 in PBSS medium supplemented with valine, leucine or isoleucine."
29312195
reach
"These results confirmed that the branched-chain DSF family signals produced by KH2 were from conversion of exogenous BCAAs and that KIV and KIC were the precursors of the DSF signal, and KMV was the precursor of the IDSF signal."
29312195
KCNG1 affects 3HA
| 4
KCNG1 binds 3HA. 4 / 4
| 4
sparser
"As comparators, we also engineered an NF54 C580Y attB line co-expressing GFP-K13 C580Y as well as an NF54 WT attB line co-expressing 3HA-K13 WT ( xref )."
32310999
sparser
"As comparators, we also engineered an NF54 C580Y attB line co-expressing GFP-K13 C580Y as well as an NF54 WT attB line co-expressing 3HA-K13 WT ( xref )."
32310999
sparser
"Co-expression of GFP-K13 WT or 3HA-K13 C580Y in our NF54 WT attB epitope-tagged lines (see above) led to ART sensitivity, with RSA values of 0.8% and 0.7% in the NF54 WT attB-GFP-K13 WT and NF54 WT attB-3HA-K13 C580Y lines, respectively."
32310999
sparser
"Co-expression of GFP-K13 WT or 3HA-K13 C580Y in our NF54 WT attB epitope-tagged lines (see above) led to ART sensitivity, with RSA values of 0.8% and 0.7% in the NF54 WT attB-GFP-K13 WT and NF54 WT attB-3HA-K13 C580Y lines, respectively."
32310999
HSP90 affects KCNG1
| 4
HSP90 binds KCNG1. 2 / 2
| 2
sparser
"Thus, NEMO is essential for the interaction of K13 with HSP90."
23881928
sparser
"To check whether NEMO is required for the interaction of K13 with HSP90, we used FLAG-tagged K13-expressing wild-type and NEMO-deficient Jurkat cells."
23881928
HSP90 binds DLST and KCNG1. 1 / 1
| 1
sparser
"While we readily detected an interaction between K13 and HSP90 in the wild-type Jurkat cells using the co-IP assay, we failed to observe this interaction in the NEMO-deficient cells ( xref )."
23881928
HSP90 binds IKBKG and KCNG1. 1 / 1
| 1
sparser
"K13 interacts with HSP90 via NEMO."
23881928
CHUK affects IKBKB, and KCNG1
| 4
CHUK binds IKBKB and KCNG1. 4 / 4
| 4
sparser
"Therefore, to explain the role of NEMO in K13-inducd NF-κB activation, we tested the hypothesis that NEMO mediates the interaction between K13 and IKK1 and IKK2."
22590573
sparser
"Instead, NEMO is required for mediating the interaction between K13 and IKK1 and IKK2."
22590573
sparser
"As shown in xref , while interaction of K13 with NEMO, IKK1, and IKK2 was readily detected in samples immunoprecipitated with Flag antibody from wild-type Jurkat cells, no significant interaction between K13 and IKK1 or IKK2 was observed in the NEMO-deficient Jurkat cells, Stimulation of cells with TNFα or IL-1 induces recruitment of IKK1 and IKK2 to NEMO and their subsequent phosphorylation and activation xref , xref ."
22590573
sparser
"Conversely, the KSHV protein K13 interacts with the IKKα-IKKβ complex such that NFκb is activated 98 ."
18989317
3HA affects KCNG1
| 4
KCNG1 binds 3HA. 4 / 4
| 4
sparser
"As comparators, we also engineered an NF54 C580Y attB line co-expressing GFP-K13 C580Y as well as an NF54 WT attB line co-expressing 3HA-K13 WT ( xref )."
32310999
sparser
"As comparators, we also engineered an NF54 C580Y attB line co-expressing GFP-K13 C580Y as well as an NF54 WT attB line co-expressing 3HA-K13 WT ( xref )."
32310999
sparser
"Co-expression of GFP-K13 WT or 3HA-K13 C580Y in our NF54 WT attB epitope-tagged lines (see above) led to ART sensitivity, with RSA values of 0.8% and 0.7% in the NF54 WT attB-GFP-K13 WT and NF54 WT attB-3HA-K13 C580Y lines, respectively."
32310999
sparser
"Co-expression of GFP-K13 WT or 3HA-K13 C580Y in our NF54 WT attB epitope-tagged lines (see above) led to ART sensitivity, with RSA values of 0.8% and 0.7% in the NF54 WT attB-GFP-K13 WT and NF54 WT attB-3HA-K13 C580Y lines, respectively."
32310999
NOG affects KCNG1
3 |
Transcriptionally active NOG increases the amount of KCNG1. 3 / 3
3 |
biopax:ctd
No evidence text available
27188386
biopax:ctd
No evidence text available
27188386
biopax:ctd
No evidence text available
27188386
MALT1 affects KCNG1
| 3
KCNG1 binds MALT1. 2 / 2
| 2
sparser
"K13 directly or indirectly interacted with MALT1 and in particular its protease domain, and may thus induce a conformational change in the protease domain that promotes MALT1 activation, for example, by rendering it accessible to monoubiquitination."
27538487
sparser
"K13 most likely promoted NF-κB activation by direct or indirect physical recruitment of MALT1, as K13 interacted with MALT1 but not with BCL10 upon co-expression of the proteins in 293 T cells ( xref )."
27538487
Protease binds KCNG1 and MALT1. 1 / 1
| 1
sparser
"K13 directly interacted with the protease domain of MALT1 and may thus induce an active (or activatable) MALT1 conformation."
29560084
KH3 affects KCNG1
| 3
KCNG1 binds KH3. 3 / 3
| 3
reach
"We found that the KH2 can interact with both KH1 and KH3, and KH3 alone can activate the reporter gene expression in yeast cells (XREF_SUPPLEMENTARY)."
23874224
reach
"NMR CSP data obtained titrating 15 N labelled KH23 with the TNFalpha 12mer (XREF_FIG A) revealed not only that both KH2 and KH3 bind RNA using the ' classical ' nucleic acid binding grooves (XREF_FIG B), but also that KH2- and KH3 binding surfaces do not coalesce."
20385598
reach
"Our data indicate that an interaction between KH2 and KH3 is taking place in which the linker plays a pivotal role."
20385598
KCNG1 affects H2AC20
| 3
KCNG1 ubiquitinates H2AC20.
| 2
KCNG1 ubiquitinates H2AC20. 2 / 2
| 2
sparser
"Akin to its interaction with ubiquitylated NCP, RNF169 favored K15- over K13-ubiquitylated H2A-H2B with corresponding K d s of 0.3 μM and 1.1 μM ( xref )."
28506460
sparser
"For RNF168, the K d s were 1.2, 2.3 and 3.6 μM for K15-, K13K15- and K13-ubiquitylated H2A-H2B, respectively ( xref )."
28506460
KCNG1 binds H2AC20.
| 1
Ubiquitin binds H2AC20 and KCNG1. 1 / 1
| 1
sparser
"PBAF Promotes H2AK119ub but Not H2A K13/15-Dependent Ubiquitin Chain Formation."
25066234
KCNG1 affects DSF-family
| 3
KCNG1 activates DSF-family. 3 / 3
| 3
reach
"These results confirmed that the branched-chain DSF family signals produced by KH2 were from conversion of exogenous BCAAs and that KIV and KIC were the precursors of the DSF signal, and KMV was the precursor of the IDSF signal."
29312195
reach
"To determine if branched-chain DSF family signals produced by mutant strain KH2 were from conversion of exogenous BCAAs, we tested DSF family signal production by resting cells of mutant strain KH2 in PBSS medium supplemented with valine, leucine or isoleucine."
29312195
reach
"These results indicated that strain KH2 failed to synthesize branch-chain DSF family signals from carbohydrate metabolism."
29312195
TRAF2 affects KCNG1
| 2
TRAF2 binds KCNG1. 1 / 1
| 1
sparser
"The K13-TRAF2 interaction is believed to be essential for the recruitment of K13 to the I-kappaB kinase (IKK) complex and for K13-induced NF-kappaB and JNK activation."
17597077
TRAF2 binds TRAF3 and KCNG1. 1 / 1
| 1
sparser
"Furthermore, endogenously expressed TRAF2 and TRAF3 do not interact with K13 and play no role in K13-induced NF-kappaB activation or its interaction with the IKK complex."
17597077
SEC24A affects KCNG1
| 2
SEC24A binds KCNG1. 2 / 2
| 2
sparser
"Our co-IP data suggested that K13 might also partially associate with the transitional ER marker Sec24a, involved in vesicle budding from the ER."
32310999
sparser
"Our co-IP data suggested that K13 might also partially associate with the transitional ER marker Sec24a, involved in vesicle budding from the ER."
32310999
RNF168 affects KCNG1
| 2
RNF168 ubiquitinates KCNG1. 2 / 2
| 2
sparser
"The K63-linked polyubiquitin chains recruit the E3 ubiquitin ligase RNF168, which ubiquitylates histone H2A on K13 and K15 [ xref , xref ]."
28681078
sparser
"While RNF168 can ubiquitylate H2A K13 or K15 in vitro and in vivo xref , xref , we tested whether 53BP1 displayed selectivity towards K13ub or K15ub."
23760478
KCNG1 affects dsbA
| 2
KCNG1 activates dsbA. 2 / 2
| 2
reach
"Resting KH2 cells produced DSF when valine or leucine was added to PBSS medium, while addition of isoleucine to PBSS medium resulted in IDSF production."
29312195
reach
"Addition of KIV and KIC resulted in KH2 production of DSF, while addition of KMV resulted in production of the IDSF signal."
29312195
KCNG1 affects construct
| 2
KCNG1 activates construct. 2 / 2
| 2
sparser
"K13 could effectively activate a HIV-1 LTR reporter construct lacking the Tat binding site but failed to activate a construct lacking the NF-kappaB binding sites."
15713234
sparser
"K13 could effectively activate a HIV-1 LTR reporter construct lacking the Tat binding site but failed to activate a construct lacking the NF-κB binding sites."
15713234
KCNG1 affects apoptotic process
| 2
KCNG1 inhibits apoptotic process. 2 / 2
| 2
sparser
"Inhibition of anti-IgM-induced apoptosis by K13 may contribute to the development of KSHV-associated lymphoproliferative disorders."
23236068
sparser
"Other viral genes code for proteins that are also implicated in oncogenesis: viral interferon regulatory factor-1 (v-IRF-1) suppresses both type I and type II interferon responses; K13 (aka vFLIP) inhibits Fas-mediated apoptosis; viral g-protein-coupled receptor (vGPCR), a homologue of the IL-8 receptor, produces tumors when vGPCR-expressing fibroblasts are injected into nude mice [ xref – xref ]."
21253546
KCNG1 affects TRAF2
| 2
TRAF2 binds KCNG1. 1 / 1
| 1
sparser
"The K13-TRAF2 interaction is believed to be essential for the recruitment of K13 to the I-kappaB kinase (IKK) complex and for K13-induced NF-kappaB and JNK activation."
17597077
TRAF2 binds TRAF3 and KCNG1. 1 / 1
| 1
sparser
"Furthermore, endogenously expressed TRAF2 and TRAF3 do not interact with K13 and play no role in K13-induced NF-kappaB activation or its interaction with the IKK complex."
17597077
KCNG1 affects SEC24A
| 2
SEC24A binds KCNG1. 2 / 2
| 2
sparser
"Our co-IP data suggested that K13 might also partially associate with the transitional ER marker Sec24a, involved in vesicle budding from the ER."
32310999
sparser
"Our co-IP data suggested that K13 might also partially associate with the transitional ER marker Sec24a, involved in vesicle budding from the ER."
32310999
KCNG1 affects PCBP1
| 2
KCNG1-G296A activates PCBP1. 1 / 1
| 1
reach
"Amino acid substitution mutations of G30A, KH2 G114A and G296A in GXXG motif of KH domain were produced to break KH1, KH2 and KH3 of PCBP1, respectively [XREF_BIBR]."
30086790
KCNG1-G114A activates PCBP1. 1 / 1
| 1
reach
"Amino acid substitution mutations of G30A, KH2 G114A and G296A in GXXG motif of KH domain were produced to break KH1, KH2 and KH3 of PCBP1, respectively [XREF_BIBR]."
30086790
KCNG1 affects NFKBIA
| 2
KCNG1 phosphorylates NFKBIA. 2 / 2
| 2
sparser
"Overexpression of A20 blocked K13-induced IκBα phosphorylation, NF-κB nuclear translocation, and cellular transformation."
21531730
sparser
"Consistent with the above, K13-induced IκBα phosphorylation and NF-κB transcriptional activation were enhanced in A20-deficient cells."
21531730
KCNG1 affects MIR146A
| 2
KCNG1 activates MIR146A. 2 / 2
| 2
eidos
"The M type K15 protein of KSHV induces the expression of microRNAs miR-21 and miR-31 via this conserved motif [ 42 ] , while K13 strongly stimulated upregulation of miR-146a [ 43 ] ."
| PMC
eidos
"The M type K15 protein of KSHV induces the expression of microRNAs miR-21 and miR-31 via this conserved motif [ 90 ] , while K13 strongly stimulated upregulation of miR-146a [ 91 ] ."
| PMC
KCNG1 affects MAPK9
| 2
KCNG1 activates MAPK9. 2 / 2
| 2
sparser
"The K13-TRAF2 interaction is believed to be essential for the recruitment of K13 to the I-kappaB kinase (IKK) complex and for K13-induced NF-kappaB and JNK activation."
17597077
sparser
"In addition, TRAF3 has been reported to be required for K13-induced NF-kappaB and JNK activation."
17597077
KCNG1 affects KLK3
| 1 1
KCNG1 activates KLK3. 2 / 2
| 1 1
reach
"[XREF_BIBR] Evidence from in vitro studies suggests that PSA is activated by kH2, a protein that is encoded by the closely related gene, kallikrein 2 (KLK2)."
28272245
sparser
"The PSA protein is encoded by the kallikrein 3 ( KLK3 ) gene, and the expression of PSA is mediated by the androgen receptor in both healthy and cancerous prostate tissues.[ xref ]Evidence from in vitro studies suggests that PSA is activated by kH2, a protein that is encoded by the closely related gene, kallikrein 2 ( KLK2 ).[ xref ]PSA is also involved in the proteolytic breakdown of the extracellular matrix in PCa tumorigenesis, which contributes to tumor invasion and metastasis,[ xref ]and high serum PSA correlates with mutations in p53 and the overexpression of the B-cell lymphoma 2 protein, which inhibits apoptosis in tumor cells.[ xref ]These findings strongly suggest that PSA plays a role in the etiology of PCa."
28272245
KCNG1 affects JNK
| 2
JNK binds KCNG1. 1 / 1
| 1
sparser
"The enhanced resistance to apoptosis, loss of contact inhibition, and predisposition to anchorage-independent growth in the K12 transformants were associated with higher AKT/protein kinase B activation, bcl-2, E-cadherin, beta-catenin, and focal adhesion kinase overexpression, and RhoA underexpression, whereas the increased sensitivity of K13 or Kwt-oe transformants to apoptosis was associated with increased activation of the c-Jun-NH2-terminal kinase 1 pathway."
11118062
IKK_complex binds JNK, NFkappaB, and KCNG1. 1 / 1
| 1
sparser
"Our results support a model in which K13 bypasses the upstream components of the tumor necrosis factor receptor signaling pathway and directly interacts with the IKK complex to selectively activate the NF-kappaB pathway without affecting the JNK pathway."
17597077
KCNG1 affects Histone_H2B
| 2
KCNG1 ubiquitinates Histone_H2B. 2 / 2
| 2
sparser
"For RNF168, the K d s were 1.2, 2.3 and 3.6 μM for K15-, K13K15- and K13-ubiquitylated H2A-H2B, respectively ( xref )."
28506460
sparser
"Akin to its interaction with ubiquitylated NCP, RNF169 favored K15- over K13-ubiquitylated H2A-H2B with corresponding K d s of 0.3 μM and 1.1 μM ( xref )."
28506460
KCNG1 affects FMR1
| 2
KCNG1 binds FMR1.
| 1
FMR1 binds KCNG1. 1 / 1
| 1
reach
"Similarly, point mutations in the human FMR1 gene that disrupt the FMRP RNA binding domain KH2 also result in FXS symptoms."
25201111
KCNG1 activates FMR1.
| 1
KCNG1 activates FMR1. 1 / 1
| 1
reach
"The conserved hydrophobic residue implicated in the development of fragile X mental retardation makes an aliphatic stacking interaction with the Ade of 5 '-Ura-Cyt-Ade-Y-3 ', suggesting that the FMR1 protein deficiency phenotype is caused by impairment of RNA binding by KH2 of FMR1."
10676814
KCNG1 affects FAM189A2
2 |
FAM189A2 binds KCNG1. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
JNK affects KCNG1
| 2
JNK binds KCNG1. 1 / 1
| 1
sparser
"The enhanced resistance to apoptosis, loss of contact inhibition, and predisposition to anchorage-independent growth in the K12 transformants were associated with higher AKT/protein kinase B activation, bcl-2, E-cadherin, beta-catenin, and focal adhesion kinase overexpression, and RhoA underexpression, whereas the increased sensitivity of K13 or Kwt-oe transformants to apoptosis was associated with increased activation of the c-Jun-NH2-terminal kinase 1 pathway."
11118062
IKK_complex binds JNK, NFkappaB, and KCNG1. 1 / 1
| 1
sparser
"Our results support a model in which K13 bypasses the upstream components of the tumor necrosis factor receptor signaling pathway and directly interacts with the IKK complex to selectively activate the NF-kappaB pathway without affecting the JNK pathway."
17597077
FAM189A2 affects KCNG1
2 |
FAM189A2 binds KCNG1. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
CHUK affects IKBKB, IKBKG, and KCNG1
| 2
CHUK binds IKBKB, IKBKG, and KCNG1. 2 / 2
| 2
sparser
"We next examined if recruitment of IKK1 and IKK2 to the K13-NEMO complex is also associated with “T Loop” phosphorylation of IKK1, IKK2 or both."
22590573
sparser
"As shown in xref , while interaction of K13 with NEMO, IKK1, and IKK2 was readily detected in samples immunoprecipitated with Flag antibody from wild-type Jurkat cells, no significant interaction between K13 and IKK1 or IKK2 was observed in the NEMO-deficient Jurkat cells, Stimulation of cells with TNFα or IL-1 induces recruitment of IKK1 and IKK2 to NEMO and their subsequent phosphorylation and activation xref , xref ."
22590573
Rrn BoxC RNA affects KCNG1
| 1
KCNG1 binds rrn BoxC RNA. 1 / 1
| 1
reach
"In this complex, rrn BoxC RNA interacts predominantly with KH2."
21742261
Phorbol affects KCNG1
| 1
Phorbol activates KCNG1. 1 / 1
| 1
reach
"Adult T-cell Leukemia cell lines MT-1, MT-2, KH-2 and MT-2 stimulated by phorbol 12-myristate 13-acetate (PMA) were used as target cells in immunofluorescence microscopy (IF) examination with positive rates as 0.20% (2/965), 0.62% (6/965), 0.20% (2/965) and 0.51 (5/965) respectively."
2684368
PBS31-Hlf construct affects KCNG1
| 1
PBS31-Hlf construct activates KCNG1. 1 / 1
| 1
reach
"Next, the pBS31-Hlf construct was used to target KH2 ESCs by Flpase mediated recombination."
29166614
Lectin affects KCNG1
| 1
KCNG1 binds lectin. 1 / 1
| 1
sparser
"Consistent with this observation, bacterial binding was enhanced in vaginal epithelial cultures that were induced to differentiate, and this enhanced bacterial binding was associated with increased K13 expression levels and increased binding of the mannose-specific lectin Galanthus nivalis agglutinin."
12447740
Hsa-miR-324-5p affects KCNG1
1 |
Transcriptionally active hsa-miR-324-5p decreases the amount of KCNG1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Ferredoxin affects KCNG1
| 1
KCNG1 binds ferredoxin. 1 / 1
| 1
sparser
"Interestingly the ferredoxin D193Y background mutation was not always associated with the k13 mutations in the KH3 subpopulation."
29258508
Dihydroartemisinin affects KCNG1
| 1
Dihydroartemisinin binds KCNG1. 1 / 1
| 1
sparser
"This phenotype has been associated with mutations in the parasite k13 gene, which is sufficient to mediate enhanced survival of DHA-pulsed parasites in RSAs ( xref , xref )."
31040246
Caspase-8 activation affects KCNG1
| 1
Caspase-8 activation inhibits KCNG1. 1 / 1
| 1
eidos
"The antiapoptotic activity of vFLIP / K13 has been attributed to inhibition of caspase-8 activation ( Guasparri et al ., 2004 ) and expression of antiapoptotic proteins via NF-kappaB activation ( Sun et al ., 2003 ) ."
20813204
CY 1 affects KCNG1
| 1
KCNG1 binds cY 1. 1 / 1
| 1
reach
"Upon mutation of cY 1, we observed a significantly lower affinity for full-length hnRNP E1, and a complete loss of affinity for KH2, suggesting an interaction between cY 1 and KH2."
27067543
CGMP subfamily affects KCNG1
| 1
CGMP subfamily activates KCNG1. 1 / 1
| 1
sparser
"Sperm population speract responses in the presence of IBMX have shown that membrane potential remains hyperpolarized indicating that cGMP activation of KCNG prevails over the cAMP induced depolarization caused by SpHCN xref ."
28652586
Base affects KCNG1
| 1
Base activates KCNG1. 1 / 1
| 1
reach
"An additional factor that influences the Mgt ` concentration in the buffer is the base, or H+ acceptor, used to raise the pH of the KH2 POQ stock solution."
4616724
ZNRF4 affects KCNG1
1 |
ZNRF4 binds KCNG1. 1 / 1
1 |
biogrid
No evidence text available
28514442
UQ-10 affects KCNG1
| 1
UQ-10 activates KCNG1. 1 / 1
| 1
reach
"Introduction Prenylquinones like phylloquinone (vitamin K-l), plastoquinone-9 (PQ-9), and ubiquinones-9 and - 10 (UQ-9 and UQ-10) are synthesized by green leafy Abbreviations : KH2, vitamin K hydroquinone; KO, vitamin K epoxide; PQ-9, plastoquinone-9; UQ-9, ubiquinone-9; UQ-10, ubiquinone-10; DTT, dithiothreitol; Gla, y-carboxyglutamate; CHAPS, 3-((cholamidopropyl)-dimethylammonio)-l-propane sul- fonate * Corresponding author."
8948492
UBE2K affects KCNG1
| 1
UBE2K ubiquitinates KCNG1. 1 / 1
| 1
sparser
"Ring Finger Protein 168, E3 Ubiquitin Protein Ligase (RNF168) and RNF8 also ubiquitylate H2AX on K13, K15, K118 and K119, which initiate the formation of ubiquitin chains and recruitment of various DDR proteins containing ubiquitin-binding domain [ xref - xref ]."
25003966
TNFRSF1B affects KCNG1
| 1
TNFRSF1B activates KCNG1. 1 / 1
| 1
sparser
"In this respect, a potential involvment of c-IAPs in TRAF2-mediated NF-K13 activation by TNFR2 and CD40 was not substantiated (M. R. and D. V. G., unpublished data)."
8548810
TAOK3 affects KCNG1
| 1
TAOK3 binds KCNG1. 1 / 1
| 1
reach
"The known affinities of the four domains for the short AU rich RNA oligos follow the trend : KH3> KH4> = KH2>> KH1, while KH2, KH3 and KH4 bind the two short RNA oligos with K d s in the 100-400microM range, KH1 binds with K d> 1mM (XREF_TABLE)."
22547390
S1 affects KCNG1
| 1
KCNG1 binds S1. 1 / 1
| 1
reach
"The protein is in fact composed of an N-terminal RNAP binding domain, connected through a flexible linker to the S1, KH1 and KH2 RNA binding motifs."
23222129
RNF8 affects KCNG1
| 1
RNF8 ubiquitinates KCNG1. 1 / 1
| 1
sparser
"Ring Finger Protein 168, E3 Ubiquitin Protein Ligase (RNF168) and RNF8 also ubiquitylate H2AX on K13, K15, K118 and K119, which initiate the formation of ubiquitin chains and recruitment of various DDR proteins containing ubiquitin-binding domain [ xref - xref ]."
25003966
Parkinson Disease affects KCNG1
| 1
Parkinson Disease activates KCNG1. 1 / 1
| 1
reach
"To gain insights into the role of Erk signaling in Mek inhibition of ESCs, six samples, WT KH2 ESCs treated with or without PD for 48h (KH2_PD and KH2, respectively), iErk1; Erk KO ESCs cultured with Dox (P0), 48 and 96h after Dox withdrawal (P1 and P2, respectively), and iErk1; Erk KO ESCs cultured without Dox for 96h and treated with PD in the last 48h (P2_PD), are subjected to RNA sequencing (RNA-seq) analysis."
26981366
PSMD8 affects KCNG1
| 1
KCNG1 binds PSMD8. 1 / 1
| 1
sparser
"The stacking interaction with the Q145 carboxamide moiety is similar to the interaction of adenine 1 with the K13–S14 peptide bond."
20600125
PRP42 affects KCNG1
| 1
KCNG1 binds PRP42. 1 / 1
| 1
reach
"KH2 of Snu56 interacts with Prp42, similar to KH2 of Nova-1 that interacts with other proteins."
29051543
PRKN affects KCNG1
| 1
PRKN ubiquitinates KCNG1. 1 / 1
| 1
sparser
"We clearly showed that p62 is required to be ubiquitinated by wild-type parkin at the K13 residue and mutation at this site blocked its degradation (Fig.  xref )."
26746706
PE affects KCNG1
| 1
KCNG1 binds PE. 1 / 1
| 1
sparser
"Yang HP, Wang TC, Wang SJ, Chen SP, Wu E, Lai SQ, Chang HW, Liao CW (2013) Recombinant chimeric vaccine composed of PRRSV antigens and truncated Pseudomonas exotoxin A (PE-K13)."
26895704
PD 0325901 affects KCNG1
| 1
PD 0325901 activates KCNG1. 1 / 1
| 1
reach
"To test whether there is an Erk independent function of Mek, RNA sequencing (RNA-seq) is carried out on six samples, WT KH2 ESCs treated with or without PD0325901 (PD) for 48h (KH2_PD and KH2, respectively), iErk1; Erk KO ESCs cultured in the presence of Dox (P0), 48 and 96h after Dox withdrawal (P1 and P2, respectively), and iErk1; Erk KO ESCs cultured without Dox for 96h, and treated with PD in the last 48h (P2_PD)."
26981366
PCBP2 affects KCNG1
| 1
PCBP2 activates KCNG1. 1 / 1
| 1
reach
"We suggest that the nine extra amino acids of the PCBP2 linker domain (compared to PCBP1) extends this region and allows greater structural flexibility to accommodate the interactions of KH2 and KH3 with the RNA."
18656221
MYC affects KCNG1
| 1
KCNG1 binds MYC. 1 / 1
| 1
sparser
"To study the cooperative interaction between K13 and c-Myc in the pathogenesis of PEL, we crossed the K13 transgenic mice to iMyc(Eμ) transgenic mice that overexpress Myc."
20818173
MED36A affects KCNG1
| 1
MED36A activates KCNG1. 1 / 1
| 1
reach
"Specifically, flp mediated recombination was perfomed in KH2 ES cells, resulting in a single-copy integration downstream of the Col1a1 gene that has a TetO minimal CMV promoter -- ORF (either mouse Lin28a or human LIN28B)-pA signal."
28400788
KCNG1 affects wild-type NusA
| 1
Mutated KCNG1 activates wild-type NusA. 1 / 1
| 1
reach
"In this assay, the KH1 and KH2 mutants increased pause dwell times similarly to wild-type NusA, supporting the view that interactions of the KH domains with the nascent RNA or with RNAP are not important for the pause enhancement by NusA (XREF_FIG; XREF_TABLE)."
20600118
KCNG1 affects vitamin K-dependent coagulation factors II, VII, IX
| 1
KCNG1 activates vitamin K-dependent coagulation factors II, VII, IX. 1 / 1
| 1
reach
"XREF_BIBR These compounds act by reducing vitamin KH2 (reduced form of vitamin K) levels, thereby limiting the cofactor effect of vitamin K on the gamma carboxylation of the vitamin K dependent coagulation factors II, VII, IX, and X. VKAs also limit the effect of anticoagulant proteins, protein C and protein S, resulting in an inhibition of these proteins XREF_BIBR, XREF_BIBR because their synthesis depends on the presence of vitamin K."
26150723
KCNG1 affects rrn BoxC RNA
| 1
KCNG1 binds rrn BoxC RNA. 1 / 1
| 1
reach
"In this complex, rrn BoxC RNA interacts predominantly with KH2."
21742261
KCNG1 affects pro-inflammatory
| 1
KCNG1 activates pro-inflammatory. 1 / 1
| 1
eidos
"Interestingly , K13 expression is necessary and sufficient for the acquisition of the typical spindle shape of HHV-8-infected cells and contributes to their pro-inflammatory phenotype [ S297 , S298 ] ."
18516228
KCNG1 affects lectin
| 1
KCNG1 binds lectin. 1 / 1
| 1
sparser
"Consistent with this observation, bacterial binding was enhanced in vaginal epithelial cultures that were induced to differentiate, and this enhanced bacterial binding was associated with increased K13 expression levels and increased binding of the mannose-specific lectin Galanthus nivalis agglutinin."
12447740
KCNG1 affects innate immune response
| 1
KCNG1 activates innate immune response. 1 / 1
| 1
reach
"also investigated the ability of orally administered Enterococcus faecalis KH2 to beneficially modulate the innate immune response to influenza infection."
28066442
KCNG1 affects immune response
| 1
KCNG1 activates immune response. 1 / 1
| 1
reach
"In the present study, we evaluated whether or not oral administration of a cell preparation of E. faecalis strain KH-2 (CPEF) stimulated cell mediated immunity such as NK activity in a mouse model."
30094120
KCNG1 affects ferredoxin
| 1
KCNG1 binds ferredoxin. 1 / 1
| 1
sparser
"Interestingly the ferredoxin D193Y background mutation was not always associated with the k13 mutations in the KH3 subpopulation."
29258508
KCNG1 affects dihydroartemisinin
| 1
Dihydroartemisinin binds KCNG1. 1 / 1
| 1
sparser
"This phenotype has been associated with mutations in the parasite k13 gene, which is sufficient to mediate enhanced survival of DHA-pulsed parasites in RSAs ( xref , xref )."
31040246
KCNG1 affects constructs
| 1
KCNG1 activates constructs. 1 / 1
| 1
sparser
"Therefore, we sought to determine whether vFLIP K13 will differentially activate luciferase reporter constructs driven by LTRs derived from different HIV strains."
15713234
KCNG1 affects cis-2-dodecenoic acid
| 1
KCNG1 activates cis-2-dodecenoic acid. 1 / 1
| 1
reach
"While mutant strain KH2 produced only the BDSF signal."
29312195
KCNG1 affects cell differentiation
| 1
KCNG1 activates cell differentiation. 1 / 1
| 1
reach
"For the global screen of LIN41 's ubiquitination targets, a set of four extracts was prepared from Dox inducible Flag-Trim71 KH2 mouse ES cells (iLin41) 5 cultured in the presence or absence of Dox and maintained either 48h in the pluripotent state in the presence of LIF or subjected to RA induced differentiation for 3 days."
28430184
KCNG1 affects cY 1
| 1
KCNG1 binds cY 1. 1 / 1
| 1
reach
"Upon mutation of cY 1, we observed a significantly lower affinity for full-length hnRNP E1, and a complete loss of affinity for KH2, suggesting an interaction between cY 1 and KH2."
27067543
KCNG1 affects activation NF-kB
| 1
KCNG1 activates activation NF-kB. 1 / 1
| 1
eidos
"Thus , K13 promotes the activation of NF-kB via multiple , partially distinct molecular pathways [ S289-S292 ] , which in turn lead to ( 1 ) reduced sensitivity to death receptor-mediated [ S293 ] and intrinsic apoptosis [ 86 ] ; In addition , RID has been shown to target tyrosine kinase receptors , such as the epidermal growth factor receptor ( EGFR ) [ S304 ] ."
18516228
KCNG1 affects ZNRF4
1 |
ZNRF4 binds KCNG1. 1 / 1
1 |
biogrid
No evidence text available
28514442
KCNG1 affects TRAF2, and TRAF3
| 1
TRAF2 binds TRAF3 and KCNG1. 1 / 1
| 1
sparser
"Furthermore, endogenously expressed TRAF2 and TRAF3 do not interact with K13 and play no role in K13-induced NF-kappaB activation or its interaction with the IKK complex."
17597077
KCNG1 affects TAOK3
| 1
TAOK3 binds KCNG1. 1 / 1
| 1
reach
"The known affinities of the four domains for the short AU rich RNA oligos follow the trend : KH3> KH4> = KH2>> KH1, while KH2, KH3 and KH4 bind the two short RNA oligos with K d s in the 100-400microM range, KH1 binds with K d> 1mM (XREF_TABLE)."
22547390
KCNG1 affects SQSTM1
| 1
KCNG1 ubiquitinates SQSTM1. 1 / 1
| 1
sparser
"P62 is ubiquitinated at K13 site for proteasomal degradation."
26746706
KCNG1 affects S1
| 1
KCNG1 binds S1. 1 / 1
| 1
reach
"The protein is in fact composed of an N-terminal RNAP binding domain, connected through a flexible linker to the S1, KH1 and KH2 RNA binding motifs."
23222129
KCNG1 affects PTEN
| 1
KCNG1 ubiquitinates PTEN. 1 / 1
| 1
sparser
"Yet, in NMDA-challenged cortical neurons, inhibition of PTEN's nuclear translocation by a peptide designed to antagonize K13-ubiquitination of PTEN appears to be neuroprotective (Zhang et al., xref )."
24744697
KCNG1 affects PSMD8
| 1
KCNG1 binds PSMD8. 1 / 1
| 1
sparser
"The stacking interaction with the Q145 carboxamide moiety is similar to the interaction of adenine 1 with the K13–S14 peptide bond."
20600125
KCNG1 affects PRP42
| 1
KCNG1 binds PRP42. 1 / 1
| 1
reach
"KH2 of Snu56 interacts with Prp42, similar to KH2 of Nova-1 that interacts with other proteins."
29051543
KCNG1 affects PE
| 1
KCNG1 binds PE. 1 / 1
| 1
sparser
"Yang HP, Wang TC, Wang SJ, Chen SP, Wu E, Lai SQ, Chang HW, Liao CW (2013) Recombinant chimeric vaccine composed of PRRSV antigens and truncated Pseudomonas exotoxin A (PE-K13)."
26895704
KCNG1 affects NusA proteins
| 1
KCNG1 activates NusA proteins. 1 / 1
| 1
reach
"Other structurally characterized type II KH domains include : the KH1 and KH2 modules of the NusA proteins from Mycobacterium tuberculosis 25 and Thermotoga maritima 26), the N-terminal KH domain of Thermus thermophilus ribosomal protein S3 27), and the C-terminal KH domain of GTP binding protein Era from Escherichia coli 28)."
12628255
KCNG1 affects NFkappaB, and tat
| 1
NFkappaB binds KCNG1 and tat. 1 / 1
| 1
sparser
"We hypothesized that a functional interaction between K13-induced NF-κB and Tat may be particularly important in the early stages of HIV-1 infection when the amount of Tat is limited."
15713234
KCNG1 affects NFkappaB, and cytokine
| 1
NFkappaB binds KCNG1 and cytokine. 1 / 1
| 1
sparser
"K13 is a powerful activator of the NF-κB pathway and others and we have previously reported that K13-induced upregulation of proinflammatory cytokines in vascular endothelium cells is associated with NF-κB activation and can be blocked by genetic and pharmacological inhibitors of this pathway [ xref , xref ]."
19660139
KCNG1 affects MYC
| 1
KCNG1 binds MYC. 1 / 1
| 1
sparser
"To study the cooperative interaction between K13 and c-Myc in the pathogenesis of PEL, we crossed the K13 transgenic mice to iMyc(Eμ) transgenic mice that overexpress Myc."
20818173
KCNG1 affects MALT1, and Protease
| 1
Protease binds KCNG1 and MALT1. 1 / 1
| 1
sparser
"K13 directly interacted with the protease domain of MALT1 and may thus induce an active (or activatable) MALT1 conformation."
29560084
KCNG1 affects IRF3
| 1
KCNG1 activates IRF3. 1 / 1
| 1
sparser
"K13 induces IFNβ production ( xref ), implying that K13 may activate IRF3."
27342840
KCNG1 affects IL12
| 1
KCNG1 activates IL12. 1 / 1
| 1
reach
"The E. faecalis KH-2 used in this study also stimulates IL-12 production in murine splenocytes (Kan et al. unpublished data) and the mechanism of activation of CTLs and NK cells may have been stimulation of IL-12 production as a results of CPEF administration in the present study."
30094120
KCNG1 affects IKK_family
| 1
KCNG1 activates IKK_family. 1 / 1
| 1
sparser
"Taken collectively, the above results demonstrate that linear polyubiquitination is not required for K13-induced activation of the IKK complex and the NF-κB pathway."
22590573
KCNG1 affects IKB
| 1
IKB binds KCNG1. 1 / 1
| 1
sparser
"KSHV-encoded viral FLICE Inhibitory Protein (vFLIP) K13 binds to the IkappaB Kinase (IKK) complex to constitutively activate the NF-κB pathway, which has been shown to be essential for the survival and proliferation of PEL cells."
23881928
KCNG1 affects IDSF
| 1
KCNG1 activates IDSF. 1 / 1
| 1
reach
"However, the amount of IDSF signal produced by strain KH2 in PBSS medium containing isoleucine was lower than the DSF signal produced in PBSS medium supplemented with the same concentrations of valine or leucine."
29312195
KCNG1 affects HTN3
| 1
KCNG1 activates HTN3. 1 / 1
| 1
reach
"At lower Pb level (300 mg x kg (-1)), KH2 PO4 and K2SO4 caused Pb in soil transformed from non residual fractions to residual fraction substantially and for higher Pb level (500 mg x kg (-1)) only KH2PO4 application had similar effect."
18441941
KCNG1 affects HSP90AA1
1 |
HSP90AA1 binds KCNG1. 1 / 1
1 |
biogrid
No evidence text available
22939624
KCNG1 affects E3_Ub_ligase
| 1
E3_Ub_ligase binds KCNG1. 1 / 1
| 1
sparser
"In one hypothetical model of artemisinin sensitivity and resistance ( xref ), wild-type K13 binds a putative transcription factor and delivers it to ubiquitin ligase, which targets it for proteosomal degradation."
26237549
KCNG1 affects CXCR4
| 1
CXCR4 binds KCNG1. 1 / 1
| 1
sparser
"KSHV- and K13-induced downregulation of CXCR4 expression is associated with increased miR-146a expression."
20023696
KCNG1 affects CCL5
| 1
KCNG1 activates CCL5. 1 / 1
| 1
sparser
"K13 strongly activated the RANTES promoter as compared to empty vector-transfected cells ( xref )."
22624040
KCNF1 affects KCNG1, and M9
| 1
KCNF1 binds KCNG1 and M9. 1 / 1
| 1
reach
"Consistently, binding of all three KH domains was almost completely abolished by M7, M8 and M11 substitutions whereas binding of KH1 and KH2 was moderately reduced by M9 and M10 substitutions and binding of KH3 was unaffected."
27387282
IKK_complex affects JNK, KCNG1, and NFkappaB
| 1
IKK_complex binds JNK, NFkappaB, and KCNG1. 1 / 1
| 1
sparser
"Our results support a model in which K13 bypasses the upstream components of the tumor necrosis factor receptor signaling pathway and directly interacts with the IKK complex to selectively activate the NF-kappaB pathway without affecting the JNK pathway."
17597077
IKB affects KCNG1
| 1
IKB binds KCNG1. 1 / 1
| 1
sparser
"KSHV-encoded viral FLICE Inhibitory Protein (vFLIP) K13 binds to the IkappaB Kinase (IKK) complex to constitutively activate the NF-κB pathway, which has been shown to be essential for the survival and proliferation of PEL cells."
23881928
Histone affects KCNG1
| 1
Histone ubiquitinates KCNG1. 1 / 1
| 1
sparser
"Histone H2A ubiquitination on K13 and K15 by the RNF168 drives DNA damage signaling [ xref ]."
28052107
HSPG2 affects KCNG1, KRT14, and KRT19
| 1
HSPG2 binds KCNG1, KRT14, and KRT19. 1 / 1
| 1
sparser
"Immunohistochemically, the lining epithelium is positive for K13, K14, and K19, perlecan, and UEA-I binding."
26116019
HSP90AA1 affects KCNG1
1 |
HSP90AA1 binds KCNG1. 1 / 1
1 |
biogrid
No evidence text available
22939624
HSP90 affects IKBKG, and KCNG1
| 1
HSP90 binds IKBKG and KCNG1. 1 / 1
| 1
sparser
"K13 interacts with HSP90 via NEMO."
23881928
H2AC20 affects KCNG1, and Ubiquitin
| 1
Ubiquitin binds H2AC20 and KCNG1. 1 / 1
| 1
sparser
"PBAF Promotes H2AK119ub but Not H2A K13/15-Dependent Ubiquitin Chain Formation."
25066234
GNPTAB affects KCNB1, and KCNG1
| 1
GNPTAB binds KCNB1 and KCNG1. 1 / 1
| 1
sparser
"Protein-protein interactions between Kv2.1 and electrically silent Kv6.1 a-subunits were detected using two microelectrode voltage clamp and yeast two-hybrid measurements."
8980147
GNL3 affects KCNG1, and hyd WA
| 1
GNL3 binds KCNG1 and hyd WA. 1 / 1
| 1
sparser
"As per the published literature, k13 NS propeller region mutations are not always associated with artemisinin resistance."
27912758
FMR1 affects KCNG1
| 1
FMR1 binds KCNG1. 1 / 1
| 1
reach
"Similarly, point mutations in the human FMR1 gene that disrupt the FMRP RNA binding domain KH2 also result in FXS symptoms."
25201111
ELANE affects KCNG1, and ShPI-1
| 1
ELANE binds KCNG1 and ShPI-1. 1 / 1
| 1
sparser
"On the other hand, the results obtained from the MD simulations of the disrupted complexes also revealed the importance of the long-ranged electrostatic interaction between D226 of HNE and K13 of ShPI-1 in the binding process."
26372354
E3_Ub_ligase affects KCNG1
| 1
E3_Ub_ligase binds KCNG1. 1 / 1
| 1
sparser
"In one hypothetical model of artemisinin sensitivity and resistance ( xref ), wild-type K13 binds a putative transcription factor and delivers it to ubiquitin ligase, which targets it for proteosomal degradation."
26237549
DSF-family affects KCNG1
| 1
DSF-family activates KCNG1. 1 / 1
| 1
reach
"Production of DSF family signals of the mutant strain KH2 grown in NA medium was first tested."
29312195
DSF affects KCNG1
| 1
DSF activates KCNG1. 1 / 1
| 1
reach
"Production of DSF family signals of the mutant strain KH2 grown in NA medium was first tested."
29312195
DLST affects HSP90, and KCNG1
| 1
HSP90 binds DLST and KCNG1. 1 / 1
| 1
sparser
"While we readily detected an interaction between K13 and HSP90 in the wild-type Jurkat cells using the co-IP assay, we failed to observe this interaction in the NEMO-deficient cells ( xref )."
23881928
CXCR4 affects KCNG1
| 1
CXCR4 binds KCNG1. 1 / 1
| 1
sparser
"KSHV- and K13-induced downregulation of CXCR4 expression is associated with increased miR-146a expression."
20023696
CHUK affects IKBKB, KCNG1, and NFkappaB
| 1
NFkappaB binds CHUK, IKBKB, and KCNG1. 1 / 1
| 1
sparser
"KSHV protein K13 interacts with the IKKa-IKKb complex to prevent NF-κB inhibition ( xref )."
27650455
CD40 affects KCNG1
| 1
CD40 activates KCNG1. 1 / 1
| 1
sparser
"In this respect, a potential involvment of c-IAPs in TRAF2-mediated NF-K13 activation by TNFR2 and CD40 was not substantiated (M. R. and D. V. G., unpublished data)."
8548810
AGRP affects KCNG1, and hyd WA
| 1
AGRP binds KCNG1 and hyd WA. 1 / 1
| 1
sparser
"Importantly, K13-propeller mutations more accurately identify slow-clearing parasites than KH group ( xref ), demonstrating that the association of K13-propeller polymorphism with clinical ART resistance in Cambodia is partially independent of the genetic background of KH subpopulations."
24352242