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phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading

P14_3_3 affects KCNF1
| 4
| 4
sparser
"We also show that phospho-KH1 interacts directly and specifically with 14-3-3 in vitro and phosphorylation of Ser193 causes a 14-3-3-dependent alteration of the nuclear/cytoplasmic distribution of the protein."
sparser
"To confirm that this model is applicable to our data and to show that the 14-3-3-KH1 interaction is indeed mediated by a short unfolded and phosphorylated amino acid stretch we have used a 10-fold excess of a phospho-peptide that spans the KH1 14-3-3 target sequence (GLPERSVS p LTGAPES) to compete out 14-3-3 protein."
sparser
"14-3-3KH1 interaction regulates the mRNA decay activity of KSRP by sequestering the protein in a separate functional pool."
sparser
"The experiments described above show that KH1 interacts with 14-3-3 only when the domain is phosphorylated and unfolded and that, as we previously proposed xref , this interaction is mediated by a short target sequence within the domain."
PCBP2 affects KCNF1
| 4
| 3
sparser
"The data demonstrate interaction of isolated PCBP2 KH1 and KH3 domains to four distinct target sites within the 5'-nontranslated region of the CVB3 genomic RNA."
sparser
"In this model, the extensive interactions of PCBP2's KH1 domain with d10c would clearly be critical for its function and would account for the strict requirement for this domain in initiation on Type 1 IRESs ( xref , xref )."
sparser
"The KH1 domain of PCBP2 binds near the cadicivirus GNRA tetraloop and is essential for initiation."
MAVS binds KCNF1 and PCBP2. 1 / 1
| 1
sparser
"When we re-evaluated the interaction of PCBP2 with MAVS, we found that MAVS specifically interacted with the KH1 domain of PCBP2, which is the same domain that bound EPRS ( xref and Supplementary Fig. 7a,b )."
KCNF1 affects p14_3_3
| 4
| 4
sparser
"We also show that phospho-KH1 interacts directly and specifically with 14-3-3 in vitro and phosphorylation of Ser193 causes a 14-3-3-dependent alteration of the nuclear/cytoplasmic distribution of the protein."
sparser
"To confirm that this model is applicable to our data and to show that the 14-3-3-KH1 interaction is indeed mediated by a short unfolded and phosphorylated amino acid stretch we have used a 10-fold excess of a phospho-peptide that spans the KH1 14-3-3 target sequence (GLPERSVS p LTGAPES) to compete out 14-3-3 protein."
sparser
"14-3-3KH1 interaction regulates the mRNA decay activity of KSRP by sequestering the protein in a separate functional pool."
sparser
"The experiments described above show that KH1 interacts with 14-3-3 only when the domain is phosphorylated and unfolded and that, as we previously proposed xref , this interaction is mediated by a short target sequence within the domain."
KCNF1 affects PCBP2
| 4
| 3
sparser
"The data demonstrate interaction of isolated PCBP2 KH1 and KH3 domains to four distinct target sites within the 5'-nontranslated region of the CVB3 genomic RNA."
sparser
"In this model, the extensive interactions of PCBP2's KH1 domain with d10c would clearly be critical for its function and would account for the strict requirement for this domain in initiation on Type 1 IRESs ( xref , xref )."
sparser
"The KH1 domain of PCBP2 binds near the cadicivirus GNRA tetraloop and is essential for initiation."
MAVS binds KCNF1 and PCBP2. 1 / 1
| 1
sparser
"When we re-evaluated the interaction of PCBP2 with MAVS, we found that MAVS specifically interacted with the KH1 domain of PCBP2, which is the same domain that bound EPRS ( xref and Supplementary Fig. 7a,b )."
ATR2 affects KCNF1
| 2 2
ATR2 binds KCNF1.
| 2 1
| 2 1
sparser
"Autoinhibition of NusA is mediated by AR2-KH1 interaction and released by αCTD."
reach
"This binding releases anauto-inhibitory interaction between AR2 and KH1 and promotes RNA binding to NusA."
sparser
"In contrast to KH1, resonances from the S1 and KH2 regions were not affected, suggesting that AR2 interacts exclusively with the KH1 domain (Figure xref , xref )."
ATR2 inhibits KCNF1.
| 1
ATR2 inhibits KCNF1. 1 / 1
| 1
reach
"Addition of alphaCTD to the SKK : AR2 complex reversed the chemical shift changes induced in the KH1 signals on AR2 addition (XREF_FIG), confirming that alphaCTD promotes NusA binding to RNA by displacing AR2 from SKK."
PCBP1 affects KCNF1
| 3
| 2
sparser
"Our results revealed that break of PCBP1 KH1 domain apparently mitigated p27 protein expression and the reporter activity, but not the KH2 and KH3 mutations, indicating that PCBP1 binds to p27 mRNA mainly through its KH1 domain, rather than KH2 and KH3 domains, which is consistent to that PCBP1 KH1 domain interacts with stem-loops I and IV of EV71 5’UTR, facilitating viral replication [ xref ]."
sparser
"Thus, we proposed that KH1 domain of PCBP1 specifically binds to stem-loop I and IV of EV71 5′UTR, which may play an important biological function in viral replication."
| 1
sparser
"Our results revealed that break of PCBP1 KH1 domain apparently mitigated p27 protein expression and the reporter activity, but not the KH2 and KH3 mutations, indicating that PCBP1 binds to p27 mRNA mainly through its KH1 domain, rather than KH2 and KH3 domains, which is consistent to that PCBP1 KH1 domain interacts with stem-loops I and IV of EV71 5’UTR, facilitating viral replication [ xref ]."
KHSRP affects KCNF1
| 1 2
KHSRP binds KCNF1.
| 1 1
| 1 1
sparser
"KH1 binding to KSRP AU-rich target sequences is significantly weaker than the binding of the other domains (at least 10-fold weaker than KH3), while the differences between KH2, KH3 and KH4 are only 2- to 3-fold ( xref )."
reach
"KH1 binding to KSRP AU rich target sequences is significantly weaker than the binding of the other domains (at least 10-fold weaker than KH3), while the differences between KH2, KH3 and KH4 are only 2- to 3-fold."
KHSRP inhibits KCNF1.
| 1
KHSRP inhibits KCNF1. 1 / 1
| 1
reach
"To further examine whether the interaction of KSRP with the exosome is necessary for RNA decay, the decay of ARE tnf was examined in the KSRP depleted S100 supplemented with KSRP and either GST-KH 3 or GST-KH 1."
| 3
reach
"3.5 KH-1 Enhances Apoptosis Pathways."
reach
"In contrast to KH-1 (valence = 0, and 1.2), which only triggered moderate apoptosis, KH-1 with higher valences of 5.4, 9.4 and 16.6 significantly enhanced apoptosis, highlighting the importance of multivalence."
reach
"We next determined the optimal valence of KH-1 to initiate intracellular apoptosis response (XREF_FIG)."
KCNF1 affects PCBP1
| 3
| 2
sparser
"Our results revealed that break of PCBP1 KH1 domain apparently mitigated p27 protein expression and the reporter activity, but not the KH2 and KH3 mutations, indicating that PCBP1 binds to p27 mRNA mainly through its KH1 domain, rather than KH2 and KH3 domains, which is consistent to that PCBP1 KH1 domain interacts with stem-loops I and IV of EV71 5’UTR, facilitating viral replication [ xref ]."
sparser
"Thus, we proposed that KH1 domain of PCBP1 specifically binds to stem-loop I and IV of EV71 5′UTR, which may play an important biological function in viral replication."
| 1
sparser
"Our results revealed that break of PCBP1 KH1 domain apparently mitigated p27 protein expression and the reporter activity, but not the KH2 and KH3 mutations, indicating that PCBP1 binds to p27 mRNA mainly through its KH1 domain, rather than KH2 and KH3 domains, which is consistent to that PCBP1 KH1 domain interacts with stem-loops I and IV of EV71 5’UTR, facilitating viral replication [ xref ]."
KCNF1 affects KHSRP
| 1 2
KCNF1 binds KHSRP.
| 1 1
| 1 1
sparser
"KH1 binding to KSRP AU-rich target sequences is significantly weaker than the binding of the other domains (at least 10-fold weaker than KH3), while the differences between KH2, KH3 and KH4 are only 2- to 3-fold ( xref )."
reach
"KH1 binding to KSRP AU rich target sequences is significantly weaker than the binding of the other domains (at least 10-fold weaker than KH3), while the differences between KH2, KH3 and KH4 are only 2- to 3-fold."
KCNF1 inhibits KHSRP.
| 1
KCNF1 inhibits KHSRP. 1 / 1
| 1
reach
"Unfolding of KH1 does not impair the ability of KSRP to bind the mRNA, since the KH3 and KH4 domains of KSRP mediate high affinity RNA binding to the ARE in TNF-alpha."
KCNF1 affects ATR2
| 2 1
| 2 1
sparser
"Autoinhibition of NusA is mediated by AR2-KH1 interaction and released by αCTD."
reach
"This binding releases anauto-inhibitory interaction between AR2 and KH1 and promotes RNA binding to NusA."
sparser
"In contrast to KH1, resonances from the S1 and KH2 regions were not affected, suggesting that AR2 interacts exclusively with the KH1 domain (Figure xref , xref )."
AKT affects KCNF1
| 2 1
AKT phosphorylates KCNF1. 3 / 3
| 2 1
sparser
"Two independent phosphorylation events are involved in KHSRP-mediated mRNA degradation: p38 MAPK phosphorylated C-terminal Thr692 regulated the decay of ARE-containing myogenic mRNAs, while AKT phosphorylated KH1 domain reduced the degradation rate of mRNAs [51,52] ."
sparser
"AKT phosphorylation of KH1 is responsible for its unfolding, which creates a binding site for 14-3-3."
reach
"AKT phosphorylation of KH1 is responsible for its unfolding, which forms the binding site for 14-3-3zeta."
Kh affects KCNF1
| 2
| 2
sparser
"Our model for PRRSV −2/−1 PRF is that PCBPs interact with the PRRSV mRNA through KH1 and KH3, with each domain contacting one of the two C-patches (CCCA and CUCC) within the C-rich region."
sparser
"We found that the KH2 can interact with both KH1 and KH3, and KH3 alone can activate the reporter gene expression in yeast cells ( xref )."
Gold atom affects KCNF1
| 2
reach
"This may explain why KH1 binds to AU rich sequences with an affinity significantly lower than that of the other domains."
reach
"Finally, KH1 binds to the AU rich elements very weakly but discriminates effectively in favour of the SIA targets (uUGGG) (XREF_FIG a)."
KCNF1 affects translation
| 2
| 2
reach
"Furthermore, KH1 acts as a dominant negative mutant to inhibit translation from a poliovirus reporter gene in both Xenopus laevis oocytes and HeLa cell in vitro translation extracts."
reach
"KH1 and KH3 bind to poly (C) homopolymers and KH1 acts as a dominant negative mutant to inhibit translation of poliovirus XREF_BIBR, XREF_BIBR."
KCNF1 affects mTOR2
| 2
KCNF1 inhibits mTOR2. 2 / 2
| 2
reach
"Although the inhibition of mTOR2 induced by GDC-0980 alone was not as significant as PI3K or mTOR1, further addition of KH-1 markedly decreased mTOR2 activity."
reach
"However, the participation of KH-1 potentiated the GDC-0980-mediated inhibition of mTOR2, thereby catalyzing full deactivation of Akt."
KCNF1 affects kh
| 2
| 2
sparser
"Our model for PRRSV −2/−1 PRF is that PCBPs interact with the PRRSV mRNA through KH1 and KH3, with each domain contacting one of the two C-patches (CCCA and CUCC) within the C-rich region."
sparser
"We found that the KH2 can interact with both KH1 and KH3, and KH3 alone can activate the reporter gene expression in yeast cells ( xref )."
KCNF1 affects gold atom
| 2
reach
"This may explain why KH1 binds to AU rich sequences with an affinity significantly lower than that of the other domains."
reach
"Finally, KH1 binds to the AU rich elements very weakly but discriminates effectively in favour of the SIA targets (uUGGG) (XREF_FIG a)."
KCNF1 affects NFkappaB
| 2
| 2
reach
"Both GDC-0980 and KH-1 inhibited NF-kappaB to some degree, but the lowest level of NF-kappaB occurred when they were combined (XREF_FIG)."
reach
"In addition, GDC-0980 and KH-1 also worked together to down-regulate NF-kappaB and Bcl-2 which are broadly associated with oncogenesis through their ability to facilitate cell progression."
KCNF1 affects IV/C RNA
| 2
KCNF1 binds IV/C RNA. 2 / 2
| 2
reach
"Domain KH1 interacts with IV/C RNA but not with IV/B (data not shown); in contrast, KH3 binds to IV/B but not to IV/C (data not shown)."
reach
"For closely related CVB3, individual KH1 and KH3 domains of PCBP bind to IRES stem loop IV, KH1 interacts with subdomain IV/C RNA, whereas KH3 interacts with subdomain IV/B."
KCNF1 affects CASP3
| 2
KCNF1 inhibits CASP3.
| 1
KCNF1 inhibits CASP3. 1 / 1
| 1
reach
"Full-length CAGE, but not KH1 deletion construct, conferred resistance to trastuzumab in Malme3M cells, prevented caspase-3 activity from increasing in response to trastuzumab in Malme3M cells and prevented cleavage of PARP in response to trastuzumab in Malme3M cells."
KCNF1 activates CASP3.
| 1
KCNF1 activates CASP3. 1 / 1
| 1
reach
"We discovered that GDC-0980 and KH-1 could cooperate to promote caspase-3 activation (XREF_FIG)."
IV/C RNA affects KCNF1
| 2
KCNF1 binds IV/C RNA. 2 / 2
| 2
reach
"Domain KH1 interacts with IV/C RNA but not with IV/B (data not shown); in contrast, KH3 binds to IV/B but not to IV/C (data not shown)."
reach
"For closely related CVB3, individual KH1 and KH3 domains of PCBP bind to IRES stem loop IV, KH1 interacts with subdomain IV/C RNA, whereas KH3 interacts with subdomain IV/B."
1 |
Transcriptionally active hsa-miR-26b-5p decreases the amount of KCNF1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
ZBP1 affects KCNF1
| 1
| 1
sparser
"The regions of ZBP1 containing the RRM domains (1–179) or KH1-KH2 (195–304) bound the zipcode with ∼100-fold less affinity than KH3-KH4."
YWHAZ affects KCNF1
| 1
| 1
sparser
"14-3-3zeta -KH1 interaction regulates the mRNA-decay activity of KSRP by sequestering the protein in a separate functional pool."
TXNL4B affects KCNF1
| 1
| 1
sparser
"This analysis showed that ct Dim2 utilizes its KH-like domain (KH1) to interact with ct Utp1, which is reminiscent of how Dim2KH1 binds to Nob1 xref ."
S1 affects KCNF1
| 1
| 1
reach
"The protein is in fact composed of an N-terminal RNAP binding domain, connected through a flexible linker to the S1, KH1 and KH2 RNA binding motifs."
OPRM1 affects KCNF1
1 |
1 |
biogrid
No evidence text available
MITF affects KCNF1
| 1
| 1
reach
"The KH1 variant could bind MITF RNA, however its binding profile does not follow the usual saturation binding curve as exhibited by the WT CRD-BP, and hence its K d value can not be determined (XREF_FIG)."
KRR1 affects KCNF1
| 1
| 1
sparser
"For example, Krr1 binds via its KH1 (KH-like) domain to Kri1, a nucleolar assembly factor associated with snR30 xref , whereas the KH1 domain of Dim2 provides a binding site for the endonuclease Nob1 xref ."
KH4 affects KCNF1
| 1
KCNF1 binds KH4. 1 / 1
| 1
reach
"Next, we have added FUSE DNA to the FIR RRM1-RRM2-FBP Nbox KH1 and KH4 complex described above and recorded again a fingerprint NMR 15 N- 1 H correlation NMR spectrum."
KCNF1 affects wild-type NusA
| 1
KCNF1 activates wild-type NusA. 1 / 1
| 1
reach
"In this assay, the KH1 and KH2 mutants increased pause dwell times similarly to wild-type NusA, supporting the view that interactions of the KH domains with the nascent RNA or with RNAP are not important for the pause enhancement by NusA (XREF_FIG; XREF_TABLE)."
KCNF1 affects poliovirus
| 1
KCNF1 inhibits poliovirus. 1 / 1
| 1
reach
"KH1 and KH3 bind to poly (C) homopolymers and KH1 acts as a dominant negative mutant to inhibit translation of poliovirus XREF_BIBR, XREF_BIBR."
KCNF1 affects lysis
| 1
KCNF1 inhibits lysis. 1 / 1
| 1
sparser
"In vitro, mucin or bovine mucus did not inhibit bacterial lysis by phage SH1 or KH1."
KCNF1 affects furosemide
| 1
| 1
reach
"We propose that KH1 mediates transit of LmxGT1 from the flagellar pocket into the flagellar membrane via interaction with the proximal portion of the flagellar axoneme."
KCNF1 affects cell cycle
| 1
| 1
reach
"As these drugs have different effects on inhibition of cell cycle with G2/M phase arrest by DTX [XREF_BIBR], S phase arrest by GEM [XREF_BIBR], and G1/G0 arrest by GDC-0980 [XREF_BIBR], we further investigated the impact of KH-1 on drug modulated cell cycle."
KCNF1 affects calcium(2+)
| 1
| 1
reach
"In contrast, GDC-0980 apparently negated the calcium influx induced by KH-1 (XREF_FIG), which might be explained by PI3K dependent extracellular calcium influx [XREF_BIBR] and potential inhibition of calcium influx by PI3K inhibitors such as GDC-0980."
KCNF1 affects ZBP1
| 1
| 1
sparser
"The regions of ZBP1 containing the RRM domains (1–179) or KH1-KH2 (195–304) bound the zipcode with ∼100-fold less affinity than KH3-KH4."
KCNF1 affects YWHAZ
| 1
| 1
sparser
"14-3-3zeta -KH1 interaction regulates the mRNA-decay activity of KSRP by sequestering the protein in a separate functional pool."
KCNF1 affects TXNL4B
| 1
| 1
sparser
"This analysis showed that ct Dim2 utilizes its KH-like domain (KH1) to interact with ct Utp1, which is reminiscent of how Dim2KH1 binds to Nob1 xref ."
KCNF1 affects S1
| 1
| 1
reach
"The protein is in fact composed of an N-terminal RNAP binding domain, connected through a flexible linker to the S1, KH1 and KH2 RNA binding motifs."
KCNF1 affects RNA binding
| 1
KCNF1-G253D inhibits RNA binding. 1 / 1
| 1
reach
"Our results also lend support to earlier mutational data which showed that RNA binding was abolished by mutating the first glycine in the conserved GXXG motifs of KH1 (G253D) and KH2 (G319D)."
KCNF1 affects PARP1
| 1
KCNF1 inhibits PARP1. 1 / 1
| 1
reach
"Full-length CAGE, but not KH1 deletion construct, conferred resistance to trastuzumab in Malme3M cells, prevented caspase-3 activity from increasing in response to trastuzumab in Malme3M cells and prevented cleavage of PARP in response to trastuzumab in Malme3M cells."
KCNF1 affects OPRM1
1 |
1 |
biogrid
No evidence text available
KCNF1 affects MITF
| 1
| 1
reach
"The KH1 variant could bind MITF RNA, however its binding profile does not follow the usual saturation binding curve as exhibited by the WT CRD-BP, and hence its K d value can not be determined (XREF_FIG)."
KCNF1 affects MAVS, and PCBP2
| 1
MAVS binds KCNF1 and PCBP2. 1 / 1
| 1
sparser
"When we re-evaluated the interaction of PCBP2 with MAVS, we found that MAVS specifically interacted with the KH1 domain of PCBP2, which is the same domain that bound EPRS ( xref and Supplementary Fig. 7a,b )."
KCNF1 affects LmxGT1
| 1
KCNF1 activates LmxGT1. 1 / 1
| 1
reach
"We propose that KH1 mediates transit of LmxGT1 from the flagellar pocket into the flagellar membrane via interaction with the proximal portion of the flagellar axoneme."
KCNF1 affects KRR1
| 1
| 1
sparser
"For example, Krr1 binds via its KH1 (KH-like) domain to Kri1, a nucleolar assembly factor associated with snR30 xref , whereas the KH1 domain of Dim2 provides a binding site for the endonuclease Nob1 xref ."
KCNF1 affects KH4
| 1
KCNF1 binds KH4. 1 / 1
| 1
reach
"Next, we have added FUSE DNA to the FIR RRM1-RRM2-FBP Nbox KH1 and KH4 complex described above and recorded again a fingerprint NMR 15 N- 1 H correlation NMR spectrum."
KCNF1 affects KH2 di-domain, and confluentin
| 1
KCNF1 binds KH2 di-domain and confluentin. 1 / 1
| 1
reach
"Further study is clearly required to test the hypothesis that confluentin binds to KH1 and KH2 di-domain to inhibit the function of IMP1."
KCNF1 affects KCNG1, and M9
| 1
KCNF1 binds KCNG1 and M9. 1 / 1
| 1
reach
"Consistently, binding of all three KH domains was almost completely abolished by M7, M8 and M11 substitutions whereas binding of KH1 and KH2 was moderately reduced by M9 and M10 substitutions and binding of KH3 was unaffected."
KCNF1 affects IV/C
| 1
KCNF1 binds IV/C. 1 / 1
| 1
reach
"Supplementary Fig. 3B shows binding of KH1 to IV/C but not to IV/C mut, IV/B and IV/B *."
KCNF1 affects GST
| 1
| 1
sparser
"An in vitro binding assay revealed that PCBP2 KH1 specifically interacted with the GST and L1 regions of EPRS (amino acids 1–196) but not with the GST-like domain alone (amino acids 1–168) ( xref and Supplementary Fig. 6a,b ), which further supported the finding that EPRS L1 was essential for interaction with PCBP2."
KCNF1 affects FUT3
| 1
KCNF1 activates FUT3. 1 / 1
| 1
reach
"16 These intense research efforts on KH-1 and its derivatives have been driven by the apparently strong immune responses induced by KH-1 as compared to monomeric Le y and Le x antigens."
KCNF1 affects FRY2/CPL1
| 1
KCNF1 binds FRY2/CPL1. 1 / 1
| 1
sparser
"The deletion analysis showing in the xref also raised a possibility of intramolecular interactions within SHI1 because KH2 inhibits the interactions of KH1 and KH3 with FRY2/CPL1."
KCNF1 affects ERBB2
| 1
KCNF1 increases the amount of ERBB2. 1 / 1
| 1
reach
"Full-length CAGE, but not KH1 deletion construct, increased the expression of pEGFR Y845 and HER2, and induced interaction of EGFR with CAGE and HER2."
KCNF1 affects EPS
| 1
KCNF1 increases the amount of EPS. 1 / 1
| 1
reach
"The activity of extracellular enzymes cellulase, amylase, and protease, and the amount of EPS produced by mutant strain KH1 were not significantly different from the wild type strain Xc1 (data not shown)."
KCNF1 affects EGFR
| 1
KCNF1 increases the amount of EGFR. 1 / 1
| 1
reach
"Full-length CAGE, but not KH1 deletion construct, increased the expression of pEGFR Y845 and HER2, and induced interaction of EGFR with CAGE and HER2."
KCNF1 affects DTX
| 1
KCNF1 activates DTX. 1 / 1
| 1
reach
"Interestingly, while KH-1 alone had little impact on cell cycle regulation, it exerted drug dependent effect on the alteration of cell cycle when combined with different drugs (XREF_FIG) : KH-1 enhanced DTX induced G2/M arrest, GEM induced S phase arrest and GDC-0980-induced G1/G0 arrest."
KCNF1 affects BCL2
| 1
KCNF1 inhibits BCL2. 1 / 1
| 1
reach
"In addition, GDC-0980 and KH-1 also worked together to down-regulate NF-kappaB and Bcl-2 which are broadly associated with oncogenesis through their ability to facilitate cell progression."
| 1
reach
"The KH1 bacteriophage reduces the population of O157 : H7 cells attached to stainless steel, but not those incased within a biofilm matrix."
KCNF1 affects 2-NAc-NAN
| 1
KCNF1 demethylates 2-NAc-NAN. 1 / 1
| 1
reach
"Since 2-NAc-NAN was not demethylated by strain KH1 (XREF_TABLE), metabolites 208a and 208b are proposed to result from demethylation of DNAN followed by two successive acetylations of the primary amine group."
IV/C affects KCNF1
| 1
KCNF1 binds IV/C. 1 / 1
| 1
reach
"Supplementary Fig. 3B shows binding of KH1 to IV/C but not to IV/C mut, IV/B and IV/B *."
| 1
sparser
"Pull-down experiments show that KH1-7 domains of vigilin interact with zinc-finger domains of CTCF."
GST affects KCNF1
| 1
| 1
sparser
"An in vitro binding assay revealed that PCBP2 KH1 specifically interacted with the GST and L1 regions of EPRS (amino acids 1–196) but not with the GST-like domain alone (amino acids 1–168) ( xref and Supplementary Fig. 6a,b ), which further supported the finding that EPRS L1 was essential for interaction with PCBP2."
FRY2/CPL1 affects KCNF1
| 1
KCNF1 binds FRY2/CPL1. 1 / 1
| 1
sparser
"The deletion analysis showing in the xref also raised a possibility of intramolecular interactions within SHI1 because KH2 inhibits the interactions of KH1 and KH3 with FRY2/CPL1."
FMR1 affects KCNF1, and NTS
| 1
FMR1 binds KCNF1 and NTS. 1 / 1
| 1
sparser
"A His-tag pulldown assay was performed to check for potential interaction of FMRP Nt-KH1 and FXR1P Nt-KH2–His 6 ."
ESR2 affects KCNF1
1 |
Transcriptionally active ESR2 increases the amount of KCNF1. 1 / 1
1 |
biopax:ctd
No evidence text available
EEF1A1 affects KCNF1, and KH2 domains
| 1
EEF1A1 binds KCNF1 and KH2 domains. 1 / 1
| 1
reach
"The results can be summarized as follows : the KH1 and KH3 domains bind the BAT element (XREF_SUPPLEMENTARY, right upper panel), whereas KH1 and KH2 domains bind eEF1A1 (XREF_SUPPLEMENTARY, right bottom panel)."
CDKN1B affects KCNF1, and PCBP1
| 1
| 1
sparser
"Our results revealed that break of PCBP1 KH1 domain apparently mitigated p27 protein expression and the reporter activity, but not the KH2 and KH3 mutations, indicating that PCBP1 binds to p27 mRNA mainly through its KH1 domain, rather than KH2 and KH3 domains, which is consistent to that PCBP1 KH1 domain interacts with stem-loops I and IV of EV71 5’UTR, facilitating viral replication [ xref ]."
BOLA2B affects KCNF1, and KH3 domains
| 1
BOLA2B binds KCNF1 and KH3 domains. 1 / 1
| 1
reach
"Although both the KH1 and the KH3 domains of PCBP1 bound to BolA2 in an Fe- and GSH dependent manner, only KH3 could support the formation of [2Fe-2S] clusters on the BolA2 and Glrx3 complex in cells."
BMP2 affects KCNF1
| 1 1
BMP2 increases the amount of KCNF1. 1 / 1
| 1 1
reach
"BMP-2 (100 nM for 18-24 h) significantly (> 2-fold) upregulated mRNA expression of KCNA5, KCNA7, KCNA10, KCNC3, KCNC4, KCNF1, KCNG3, KCNS1, and KCNS3 but downregulated (at least 2-fold) KCNAB1, KCNA2, KCNG2, and KCNV2."
BAAT affects KCNF1, and KH3 domains
| 1
KCNF1 binds BAAT and KH3 domains. 1 / 1
| 1
reach
"The results can be summarized as follows : the KH1 and KH3 domains bind the BAT element (XREF_SUPPLEMENTARY, right upper panel), whereas KH1 and KH2 domains bind eEF1A1 (XREF_SUPPLEMENTARY, right bottom panel)."
2 di-domains affects KCNF1, and confluentin
| 1
KCNF1 binds 2 di-domains and confluentin. 1 / 1
| 1
reach
"These results suggest that confluentin inhibits IMP1-KRAS RNA interaction by binding to the KH1 & 2 di-domains of IMP1."
2 di-domains affects IGF2BP1, and KCNF1
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IGF2BP1 binds KCNF1 and 2 di-domains. 1 / 1
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"These results suggest that confluentin inhibits IMP1-KRAS RNA interaction by binding to the KH1 & 2 di-domains of IMP1."
2 di-domain affects KCNF1, and confluentin
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KCNF1 binds 2 di-domain and confluentin. 1 / 1
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"Given that the only difference between KH1to4 IMP1 and KH3 & 4 IMP1 is the presence of KH1 and KH2 domains in the former, it is highly likely that confluentin binds to the KH1 & 2 di-domain to exert its inhibitory effect on IMP1-KRAS RNA interaction."
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"As calcium influx is one of the most important mechanisms underlying the effectiveness of CD20 crosslinking function [XREF_BIBR], whether GDC-0980 that abrogated calcium influx antagonized KH-1 in apoptosis was investigated."