INDRA statements for KCND3

This page allows you to curate the loaded statements. For more information please see the manual.

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
SRC affects KCND3
1 2 | 3 2
SRC binds KCND3.
2 | 1 1
SRC binds KCND3. 3 / 3
2 | 1 1
biogrid
No evidence text available
18620005
biogrid
No evidence text available
18620005
sparser
"The functional relevance of the observed interaction between Kv4.3 and c-Src was established in patch-clamp experiments, where application of the Src inhibitor PP2 caused a decrease in Kv4.3 peak current amplitude, but not the inactive structural analogue PP3."
18620005
SRC phosphorylates KCND3.
1 |
SRC phosphorylates KCND3 on Y108. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
SRC activates KCND3.
| 2 1
SRC activates KCND3. 1 / 1
| 2 1
sparser
"In conclusion, our findings provide evidence that c-Src-induced Kv4.3 channel activation involves their association in a macromolecular complex and suggest a role for c-Src-Kv4.3 pathway in regulating cardiac and neuronal excitability."
18620005
Bop affects KCND3
| 3
KCND3 binds bop. 1 / 1
| 1
sparser
"Future studies employing appropriate disease models should explore the potential electrophysiological implications in (patho)physiological conditions, including BrS associated with KCND3 gain-of-function mutations."
29593552
RANGRF binds SCN3B, KCND3, and bop. 1 / 1
| 1
sparser
"However, recently released exome data make some of the prior associations of BrS with genes SCN3B, MOG1, and KCND3 less likely."
22284586
SCN1B binds RANGRF, SCN3B, KCND3, and bop. 1 / 1
| 1
sparser
"Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS."
22284586
PSMD4 affects KCND3
| 2 1
KCND3 binds PSMD4. 2 / 2
| 2
sparser
"The results of the functional experiments were contrary to those for mutant residues at position 361 in KCND3 associated with AF."
29383177
sparser
"The presence of AF was associated with a 61% reduction in Kv4.3 mRNA expression (P < 0.001 vs SR), which was paralleled by a reduction in Ito current densities in this group of patients (i.e., at +50 mV: 7.44+/-0.76 pA/pF in SR and 1.24+/-0.28 pA/pF in AF; P < 0.001 vs SR)."
10868735
Mutated KCND3 binds PSMD4. 1 / 1
| 1
reach
"A novel KCND3 mutation associated with early-onset lone atrial fibrillation."
29383177
P90RSK affects KCND3
| 3
P90RSK phosphorylates KCND3.
| 2
P90RSK phosphorylates KCND3. 2 / 2
| 2
sparser
"P90RSK Phosphorylates Kv4.3."
18599872
sparser
"I to,f decrease was caused by p90RSK phosphorylating Kv4.3 subunit and reduction of I K,slow was due to p90RSK inhibiting Kv1.5-encoded channel activity."
18599872
P90RSK inhibits KCND3.
| 1
P90RSK inhibits KCND3. 1 / 1
| 1
sparser
"P90RSK Inhibits Kv4.3- and Kv1.5- rather than Kv4.2- and Kv2.1-encoded Channel Activities."
18599872
KCND3 affects bop
| 3
KCND3 binds bop. 1 / 1
| 1
sparser
"Future studies employing appropriate disease models should explore the potential electrophysiological implications in (patho)physiological conditions, including BrS associated with KCND3 gain-of-function mutations."
29593552
RANGRF binds SCN3B, KCND3, and bop. 1 / 1
| 1
sparser
"However, recently released exome data make some of the prior associations of BrS with genes SCN3B, MOG1, and KCND3 less likely."
22284586
SCN1B binds RANGRF, SCN3B, KCND3, and bop. 1 / 1
| 1
sparser
"Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS."
22284586
KCND3 affects SRC
2 | 1 1
SRC binds KCND3. 3 / 3
2 | 1 1
biogrid
No evidence text available
18620005
biogrid
No evidence text available
18620005
sparser
"The functional relevance of the observed interaction between Kv4.3 and c-Src was established in patch-clamp experiments, where application of the Src inhibitor PP2 caused a decrease in Kv4.3 peak current amplitude, but not the inactive structural analogue PP3."
18620005
KCND3 affects PSMD4
| 2 1
KCND3 binds PSMD4. 2 / 2
| 2
sparser
"The results of the functional experiments were contrary to those for mutant residues at position 361 in KCND3 associated with AF."
29383177
sparser
"The presence of AF was associated with a 61% reduction in Kv4.3 mRNA expression (P < 0.001 vs SR), which was paralleled by a reduction in Ito current densities in this group of patients (i.e., at +50 mV: 7.44+/-0.76 pA/pF in SR and 1.24+/-0.28 pA/pF in AF; P < 0.001 vs SR)."
10868735
Mutated KCND3 binds PSMD4. 1 / 1
| 1
reach
"A novel KCND3 mutation associated with early-onset lone atrial fibrillation."
29383177
Sodium atom affects KCND3
| 2
Sodium atom activates KCND3. 2 / 2
| 2
reach
"Silencing of Na v beta1 produced a reduction in Kv4.2, Kv4.3 and KChIP2 mRNA and protein.34 These findings suggested a structural and functional association between Na v 1.5 and Kv4.3 via Na v beta1."
30160358
reach
"In 2002, Deschenes etal33 found that Na v beta1 increased the current density of I to by modulating the gating kinetics of Kv4.3."
30160358
SEMA3A affects KCND3
1 | 1
SEMA3A binds KCND3. 2 / 2
1 | 1
biogrid
No evidence text available
24963029
sparser
"Disruption of a putative toxin binding domain on Kv4.3 was used to assess physical interactions between SEMA3A and Kv4.3."
24963029
SCN1Bbeta affects KCND3
| 2
KCND3 binds SCN1Bbeta. 2 / 2
| 2
reach
"Previously study reported that co-expressed with SCN1Bbeta/WT slowed recovery of I to from inactivation when compared with that of KCND3/WT alone.35 Besides, Co-IP study showed an impaired interaction between KCND3 and SCN1Bbeta and R250T."
30160358
reach
"Figure XREF_FIG A showed the association between Kv4.3 (~ 75kD, top) and SCN1Bbeta (~ 30kD, bottom) when co-expressed."
30160358
SCN1Bb affects KCND3
| 2
KCND3 binds SCN1Bb. 1 / 1
| 1
sparser
"To determine whether SCN1Bb proteins associate with KCND3 , we prepared extracts of TSA201 cells transfected with SCN1Bb and SCN5A , or SCN1Bb and KCND3 (n = 4). xref display western blots of the immunoprecipitated proteins showing a ~30 kDa SCN1Bb band using the anti- SCN1Bb antibody."
22155597
SCN5A binds KCND3 and SCN1Bb. 1 / 1
| 1
sparser
"These results provide evidence in support of an interaction of subsidiary SCN1Bb subunits (both WT and rare variant) with SCN5A and KCND3 subunits in the transfected cells."
22155597
RAPGEF5 affects KCND3
1 | 1 1
RAPGEF5 binds KCND3. 1 / 1
1 | 1
biogrid
No evidence text available
17725712
RAPGEF3 binds RAPGEF5, KCND3, and LRPAP1. 1 / 1
| 1
sparser
"Proteomic analysis of proteins coimmunoprecipitated with Kv4.3 revealed that Kv4.3 is associated with Rap guanine nucleotide exchange factors MR-GEF and EPAC-1."
17725712
MITF affects KCND3
| 1 1
MITF increases the amount of KCND3.
| 1
MITF increases the amount of KCND3. 1 / 1
| 1
reach
"In this model, the activity of OSNs leads to an increase in Mitf expression, and an Mitf dependent increase in the transcription of Kcnd3 in the output neurons of the OB."
| PMC
MITF binds KCND3.
| 1
KCND3 binds MITF. 1 / 1
| 1
sparser
"Analysis of two MITF ChIPseq datasets ( xref ; xref ) showed that MITF binds to intronic regions of KCND3 in 501mel melanoma cells."
| PMC
KCND3 affects sodium atom
| 2
KCND3 inhibits sodium atom. 2 / 2
| 2
reach
"Multiple mutations of genes, SCN5A, SCN1B, SCN3B, GPD1L, CACNA1C, CACNB2, KCNE3 and KCND3, have been shown to decrease cardiac Na + and Ca 2+ channel activity or increase fast transient outward K + channel activity, and they are linked to BrS."
26016905
reach
"115 In a subsequent study, co-expression of mutant SCN1B with WT-SCN5A and WT-KCND3 (separately) induced a 55.6% decrease in peak I Na and 70.6% gain of function in I to, moreover, co-immunoprecipitation revealed structural association between Na V beta1B, Na V 1.5 and K V 4.3, suggesting that the elevated level of transient outward potassium current is predominantly responsible for pathogenesis in these cases of BrS."
26671757
KCND3 affects SEMA3A
1 | 1
SEMA3A binds KCND3. 2 / 2
1 | 1
biogrid
No evidence text available
24963029
sparser
"Disruption of a putative toxin binding domain on Kv4.3 was used to assess physical interactions between SEMA3A and Kv4.3."
24963029
KCND3 affects SCN1Bbeta
| 2
KCND3 binds SCN1Bbeta. 2 / 2
| 2
reach
"Previously study reported that co-expressed with SCN1Bbeta/WT slowed recovery of I to from inactivation when compared with that of KCND3/WT alone.35 Besides, Co-IP study showed an impaired interaction between KCND3 and SCN1Bbeta and R250T."
30160358
reach
"Figure XREF_FIG A showed the association between Kv4.3 (~ 75kD, top) and SCN1Bbeta (~ 30kD, bottom) when co-expressed."
30160358
KCND3 affects SCN1Bb
| 2
KCND3 binds SCN1Bb. 1 / 1
| 1
sparser
"To determine whether SCN1Bb proteins associate with KCND3 , we prepared extracts of TSA201 cells transfected with SCN1Bb and SCN5A , or SCN1Bb and KCND3 (n = 4). xref display western blots of the immunoprecipitated proteins showing a ~30 kDa SCN1Bb band using the anti- SCN1Bb antibody."
22155597
SCN5A binds KCND3 and SCN1Bb. 1 / 1
| 1
sparser
"These results provide evidence in support of an interaction of subsidiary SCN1Bb subunits (both WT and rare variant) with SCN5A and KCND3 subunits in the transfected cells."
22155597
KCND3 affects SCA19
| 2
KCND3 activates SCA19. 1 / 1
| 1
reach
"Mutations in KCNA1 (Kv1.1) cause Episodic Ataxia, Type 1 (OMIM 160120), and those in KCND3 (Kv4.3) cause the very rare Spinocerebellar Ataxia 19 (SCA19; OMIM 607346)."
28611571
Mutated KCND3 activates SCA19. 1 / 1
| 1
reach
"KCND3 mutations cause SCA19 by impaired protein maturation and/or reduced channel function."
23280838
KCND3 affects RAPGEF5
1 | 1 1
RAPGEF5 binds KCND3. 1 / 1
1 | 1
biogrid
No evidence text available
17725712
RAPGEF3 binds RAPGEF5, KCND3, and LRPAP1. 1 / 1
| 1
sparser
"Proteomic analysis of proteins coimmunoprecipitated with Kv4.3 revealed that Kv4.3 is associated with Rap guanine nucleotide exchange factors MR-GEF and EPAC-1."
17725712
KCND3 affects DPP10
1 | 1 1
DPP10 binds KCND3. 2 / 2
1 | 1 1
sparser
"Within the N-glycosylation mutations, N257Q showed the most pronounced effects with an impaired membrane trafficking completely disrupting the interaction between Kv4.3 and DPP10."
22387313
biogrid
No evidence text available
22387313
IL1RL1 affects KCND3, and KCNIP1
| 2
KCNIP1 binds IL1RL1 and KCND3. 2 / 2
| 2
sparser
"The proximal N-terminal peptide of Kv4.3 binds to an elongated groove on the surface of KChIP1, and the same KChIP1 molecule binds to an adjacent T1 domain of another Kv4.3 subunit to stabilize the tetrameric Kv4.3 channels ( 8,14,34–36 )."
20550899
sparser
"In the second interface, the same KChIP1 molecule binds to another adjacent T1 domain of a second Kv4.3 subunit, resulting in a stabilized tetrameric Kv4.3 T1-KChIP1 complex."
20550899
DPP10 affects KCND3
1 | 1 1
DPP10 binds KCND3. 2 / 2
1 | 1 1
sparser
"Within the N-glycosylation mutations, N257Q showed the most pronounced effects with an impaired membrane trafficking completely disrupting the interaction between Kv4.3 and DPP10."
22387313
biogrid
No evidence text available
22387313
CAMK2_complex affects KCND3
| 2
CAMK2_complex phosphorylates KCND3.
| 1
CAMK2_complex phosphorylates KCND3. 1 / 1
| 1
sparser
"CaMKII can phosphorylate Kv4.3 at both diastolic and systolic Ca 2+ concentration."
21774758
CAMK2_complex binds KCND3.
| 1
CALM binds CAMK2_complex and KCND3. 1 / 1
| 1
sparser
"We have recently demonstrated that in vivo Kv4.3 transfection in LV ventricular myocytes in the normal mice significantly inhibited CaMKII activity by direct binding to the CaM binding sites and forming a CaMKII-Kv4.3 molecular complex [ xref ]."
29262619
Voltage-gated potassium channel affects KCND3
| 1
KCND3 binds voltage-gated potassium channel. 1 / 1
| 1
sparser
"This voltage-gated potassium channel is formed by the α-subunit Kv4.3 containing six transmembrane segments."
23291429
Tsh affects KCND3
| 1
Tsh decreases the amount of KCND3. 1 / 1
| 1
reach
"In human myocytes, TSH decreased the expression of KCND3 and KCNQ1, Ito and delayed rectifier K+ current (IKs) encoding proteins in a PKA dependent way."
31084419
Hsa-miR-93-5p affects KCND3
1 |
Transcriptionally active hsa-miR-93-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-8082 affects KCND3
1 |
Transcriptionally active hsa-miR-8082 decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-765 affects KCND3
1 |
Transcriptionally active hsa-miR-765 decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6506-5p affects KCND3
1 |
Transcriptionally active hsa-miR-6506-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6504-3p affects KCND3
1 |
Transcriptionally active hsa-miR-6504-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-619-5p affects KCND3
1 |
Transcriptionally active hsa-miR-619-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6124 affects KCND3
1 |
Transcriptionally active hsa-miR-6124 decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-609 affects KCND3
1 |
Transcriptionally active hsa-miR-609 decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-5589-5p affects KCND3
1 |
Transcriptionally active hsa-miR-5589-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-548v affects KCND3
1 |
Transcriptionally active hsa-miR-548v decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-526b-3p affects KCND3
1 |
Transcriptionally active hsa-miR-526b-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-520h affects KCND3
1 |
Transcriptionally active hsa-miR-520h decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-520g-3p affects KCND3
1 |
Transcriptionally active hsa-miR-520g-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-520e affects KCND3
1 |
Transcriptionally active hsa-miR-520e decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-520d-3p affects KCND3
1 |
Transcriptionally active hsa-miR-520d-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-520c-3p affects KCND3
1 |
Transcriptionally active hsa-miR-520c-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-520b affects KCND3
1 |
Transcriptionally active hsa-miR-520b decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-520a-3p affects KCND3
1 |
Transcriptionally active hsa-miR-520a-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-519d-3p affects KCND3
1 |
Transcriptionally active hsa-miR-519d-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-512-3p affects KCND3
1 |
Transcriptionally active hsa-miR-512-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-5089-5p affects KCND3
1 |
Transcriptionally active hsa-miR-5089-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4802-5p affects KCND3
1 |
Transcriptionally active hsa-miR-4802-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-4731-5p affects KCND3
1 |
Transcriptionally active hsa-miR-4731-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4638-5p affects KCND3
1 |
Transcriptionally active hsa-miR-4638-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4534 affects KCND3
1 |
Transcriptionally active hsa-miR-4534 decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-449c-5p affects KCND3
1 |
Transcriptionally active hsa-miR-449c-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-376b-3p affects KCND3
1 |
Transcriptionally active hsa-miR-376b-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-376a-3p affects KCND3
1 |
Transcriptionally active hsa-miR-376a-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-373-3p affects KCND3
1 |
Transcriptionally active hsa-miR-373-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-372-3p affects KCND3
1 |
Transcriptionally active hsa-miR-372-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-3605-5p affects KCND3
1 |
Transcriptionally active hsa-miR-3605-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-335-3p affects KCND3
1 |
Transcriptionally active hsa-miR-335-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-302e affects KCND3
1 |
Transcriptionally active hsa-miR-302e decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-302d-3p affects KCND3
1 |
Transcriptionally active hsa-miR-302d-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-302c-3p affects KCND3
1 |
Transcriptionally active hsa-miR-302c-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-302b-3p affects KCND3
1 |
Transcriptionally active hsa-miR-302b-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-302a-3p affects KCND3
1 |
Transcriptionally active hsa-miR-302a-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-26b-3p affects KCND3
1 |
Transcriptionally active hsa-miR-26b-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-2392 affects KCND3
1 |
Transcriptionally active hsa-miR-2392 decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-20b-5p affects KCND3
1 |
Transcriptionally active hsa-miR-20b-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-20a-5p affects KCND3
1 |
Transcriptionally active hsa-miR-20a-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-186-3p affects KCND3
1 |
Transcriptionally active hsa-miR-186-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-17-5p affects KCND3
1 |
Transcriptionally active hsa-miR-17-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-16-5p affects KCND3
1 |
Transcriptionally active hsa-miR-16-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-142-3p affects KCND3
1 |
Transcriptionally active hsa-miR-142-3p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
17612493
Hsa-miR-139-5p affects KCND3
1 |
Transcriptionally active hsa-miR-139-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-1306-5p affects KCND3
1 |
Transcriptionally active hsa-miR-1306-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-1304-5p affects KCND3
1 |
Transcriptionally active hsa-miR-1304-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-106b-5p affects KCND3
1 |
Transcriptionally active hsa-miR-106b-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-106a-5p affects KCND3
1 |
Transcriptionally active hsa-miR-106a-5p decreases the amount of KCND3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Dda affects KCND3
| 1
KCND3 binds dda. 1 / 1
| 1
reach
"To investigate the potential association between KCND3 and SUD and SIDS, mutational analysis of KCND3 was conducted in 123 SUDS and 292 SIDS victims using polymerase chain reaction, denaturing high-performance liquid chromatography, and direct sequencing."
22457051
Celecoxib affects KCND3
| 1
Celecoxib inhibits KCND3. 1 / 1
| 1
reach
"Celecoxib inhibited the peak KCND3 current with an IC 50 of 10.6 microM (XREF_FIG)."
22039467
Agtr1-b affects KCND3
| 1
KCND3 binds agtr1-b. 1 / 1
| 1
sparser
"Previously, we demonstrated that Kv4.3 interacts with the angiotensin type 1 receptor in HE293 cells and cardiac myocytes."
17725712
XRCC6 affects KCND3
1 |
XRCC6 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
XRCC5 affects KCND3
1 |
XRCC5 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
VPS4A affects KCND3
1 |
VPS4A binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
UQCRC2 affects KCND3
1 |
UQCRC2 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
TUBB2A affects KCND3
1 |
TUBB2A binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
TUBA1B affects KCND3
1 |
TUBA1B binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
TRbeta1 aporeceptor affects KCND3
| 1
TRbeta1 aporeceptor decreases the amount of KCND3. 1 / 1
| 1
reach
"While the TRalpha1 aporeceptor enhanced KCND3 transcription, the TRbeta1 aporeceptor suppressed KCND3 expression, with both effects exhibiting ligand dependent amplification upon T3 stimulation."
19171649
TRalpha1 aporeceptor affects KCND3
| 1
TRalpha1 aporeceptor increases the amount of KCND3. 1 / 1
| 1
reach
"While the TRalpha1 aporeceptor enhanced KCND3 transcription, the TRbeta1 aporeceptor suppressed KCND3 expression, with both effects exhibiting ligand dependent amplification upon T3 stimulation."
19171649
Sudden Infant Death affects KCND3
| 1
KCND3 binds Sudden Infant Death. 1 / 1
| 1
reach
"To investigate the potential association between KCND3 and SUD and SIDS, mutational analysis of KCND3 was conducted in 123 SUDS and 292 SIDS victims using polymerase chain reaction, denaturing high-performance liquid chromatography, and direct sequencing."
22457051
SCN1Bbeta mutations affects KCND3
| 1
KCND3 binds SCN1Bbeta mutations. 1 / 1
| 1
reach
"Co-immunoprecipitation study demonstrated an increased association between SCN1Bbeta mutations and Kv4.3 compared with SCN1Bbeta/WT (P < 0.05 and P < 0.01, respectively)."
30160358
RUVBL1 affects KCND3
1 |
RUVBL1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
RCN2 affects KCND3
1 |
KCND3 binds RCN2. 1 / 1
1 |
biogrid
No evidence text available
17725712
PYCR2 affects KCND3
1 |
PYCR2 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
NONO affects KCND3
1 |
KCND3 binds NONO. 1 / 1
1 |
biogrid
No evidence text available
17725712
NDUFS2 affects KCND3
1 |
KCND3 binds NDUFS2. 1 / 1
1 |
biogrid
No evidence text available
17725712
NAP1L1 affects KCND3
1 |
KCND3 binds NAP1L1. 1 / 1
1 |
biogrid
No evidence text available
17725712
MPP5 affects KCND3
| 1
MPP5 binds KCND3. 1 / 1
| 1
sparser
"At the protein level, KCND3 interacts with another membrane protein, DPP10, of which genetic variants have been associated with conditions including asthma xref xref ."
28139761
MAD2L2 affects KCND3
| 1
KCND3 binds MAD2L2. 1 / 1
| 1
sparser
"For instance, in human heart cells, KChIP2 may not be the only accessory subunit interacting with Kv4.3, some other K + channel accessory proteins, such as Kvβ1.3, Mink, MiRP1 and KChAP, may also be associated with K4.3 channel function [44] ."
12967631
LBR affects KCND3
1 |
KCND3 binds LBR. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects voltage-gated potassium channel
| 1
KCND3 binds voltage-gated potassium channel. 1 / 1
| 1
sparser
"This voltage-gated potassium channel is formed by the α-subunit Kv4.3 containing six transmembrane segments."
23291429
KCND3 affects thraa, and thrb
| 1
KCND3 binds thraa and thrb. 1 / 1
| 1
sparser
"To further evaluate a possible direct interaction of TRalpha1 and TRbeta1 with the KCND3 promoter, TR expression vectors were cotransfected with a construct containing 2335 bp of the KCND3 5'-flanking sequence linked to a luciferase reporter into ventricular myocytes."
19171649
KCND3 affects potassium(1+)
| 1
KCND3 activates potassium(1+). 1 / 1
| 1
reach
"Kcnd3 encodes Kv4.3 and contributes to the cardiac transient outward potassium current (I to)."
23617620
KCND3 affects dda
| 1
KCND3 binds dda. 1 / 1
| 1
reach
"To investigate the potential association between KCND3 and SUD and SIDS, mutational analysis of KCND3 was conducted in 123 SUDS and 292 SIDS victims using polymerase chain reaction, denaturing high-performance liquid chromatography, and direct sequencing."
22457051
KCND3 affects agtr1-b
| 1
KCND3 binds agtr1-b. 1 / 1
| 1
sparser
"Previously, we demonstrated that Kv4.3 interacts with the angiotensin type 1 receptor in HE293 cells and cardiac myocytes."
17725712
KCND3 affects XRCC6
1 |
XRCC6 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects XRCC5
1 |
XRCC5 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects VPS4A
1 |
VPS4A binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects UQCRC2
1 |
UQCRC2 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects TUBB2A
1 |
TUBB2A binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects TUBA1B
1 |
TUBA1B binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects TRalpha1 aporeceptor
| 1
KCND3 increases the amount of TRalpha1 aporeceptor. 1 / 1
| 1
reach
"While the TRalpha1 aporeceptor enhanced KCND3 transcription, the TRbeta1 aporeceptor suppressed KCND3 expression, with both effects exhibiting ligand dependent amplification upon T3 stimulation."
19171649
KCND3 affects Sudden Infant Death
| 1
KCND3 binds Sudden Infant Death. 1 / 1
| 1
reach
"To investigate the potential association between KCND3 and SUD and SIDS, mutational analysis of KCND3 was conducted in 123 SUDS and 292 SIDS victims using polymerase chain reaction, denaturing high-performance liquid chromatography, and direct sequencing."
22457051
KCND3 affects Spinocerebellar Ataxia 19
| 1
KCND3 activates Spinocerebellar Ataxia 19. 1 / 1
| 1
reach
"Mutations in KCNA1 (Kv1.1) cause Episodic Ataxia, Type 1 (OMIM 160120), and those in KCND3 (Kv4.3) cause the very rare Spinocerebellar Ataxia 19 (SCA19; OMIM 607346)."
28611571
KCND3 affects SCN1Bbeta mutations
| 1
KCND3 binds SCN1Bbeta mutations. 1 / 1
| 1
reach
"Co-immunoprecipitation study demonstrated an increased association between SCN1Bbeta mutations and Kv4.3 compared with SCN1Bbeta/WT (P < 0.05 and P < 0.01, respectively)."
30160358
KCND3 affects SCN1Bb, and SCN5A
| 1
SCN5A binds KCND3 and SCN1Bb. 1 / 1
| 1
sparser
"These results provide evidence in support of an interaction of subsidiary SCN1Bb subunits (both WT and rare variant) with SCN5A and KCND3 subunits in the transfected cells."
22155597
KCND3 affects SCA29
| 1
KCND3 activates SCA29. 1 / 1
| 1
reach
"In some cases, the causative gene was identical in several previously reported SCAs, so SCA15, SCA16, and SCA29 all are caused by mutations in ITPR1 and SCA19 and SCA22 are caused by mutations in KCND3 [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25055202
KCND3 affects SCA19/22
| 1
KCND3 inhibits SCA19/22. 1 / 1
| 1
reach
"Recently, loss-of function mutations in KCND3 (potassium voltage gated channel, Shal related subfamily, member 3) have been identified causing SCA19/22 [XREF_BIBR, XREF_BIBR], whereas gain-of function mutations in KCND3 were implicated in Brugada syndrome and atrial fibrillation [XREF_BIBR - XREF_BIBR]."
26189493
KCND3 affects SCA16
| 1
KCND3 activates SCA16. 1 / 1
| 1
reach
"In some cases, the causative gene was identical in several previously reported SCAs, so SCA15, SCA16, and SCA29 all are caused by mutations in ITPR1 and SCA19 and SCA22 are caused by mutations in KCND3 [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25055202
KCND3 affects SCA15
| 1
KCND3 activates SCA15. 1 / 1
| 1
reach
"In some cases, the causative gene was identical in several previously reported SCAs, so SCA15, SCA16, and SCA29 all are caused by mutations in ITPR1 and SCA19 and SCA22 are caused by mutations in KCND3 [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25055202
KCND3 affects RUVBL1
1 |
RUVBL1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects RCN2
1 |
KCND3 binds RCN2. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects RANGRF, SCN3B, and bop
| 1
RANGRF binds SCN3B, KCND3, and bop. 1 / 1
| 1
sparser
"However, recently released exome data make some of the prior associations of BrS with genes SCN3B, MOG1, and KCND3 less likely."
22284586
KCND3 affects RANGRF, SCN1B, SCN3B, and bop
| 1
SCN1B binds RANGRF, SCN3B, KCND3, and bop. 1 / 1
| 1
sparser
"Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS."
22284586
KCND3 affects PYCR2
1 |
PYCR2 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects OMIM 607346
| 1
KCND3 activates OMIM 607346. 1 / 1
| 1
reach
"Mutations in KCNA1 (Kv1.1) cause Episodic Ataxia, Type 1 (OMIM 160120), and those in KCND3 (Kv4.3) cause the very rare Spinocerebellar Ataxia 19 (SCA19; OMIM 607346)."
28611571
KCND3 affects NONO
1 |
KCND3 binds NONO. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects NDUFS2
1 |
KCND3 binds NDUFS2. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects NAP1L1
1 |
KCND3 binds NAP1L1. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects MPP5
| 1
MPP5 binds KCND3. 1 / 1
| 1
sparser
"At the protein level, KCND3 interacts with another membrane protein, DPP10, of which genetic variants have been associated with conditions including asthma xref xref ."
28139761
KCND3 affects MITF
| 1
KCND3 binds MITF. 1 / 1
| 1
sparser
"Analysis of two MITF ChIPseq datasets ( xref ; xref ) showed that MITF binds to intronic regions of KCND3 in 501mel melanoma cells."
| PMC
KCND3 affects MAD2L2
| 1
KCND3 binds MAD2L2. 1 / 1
| 1
sparser
"For instance, in human heart cells, KChIP2 may not be the only accessory subunit interacting with Kv4.3, some other K + channel accessory proteins, such as Kvβ1.3, Mink, MiRP1 and KChAP, may also be associated with K4.3 channel function [44] ."
12967631
KCND3 affects LRPAP1, RAPGEF3, and RAPGEF5
| 1
RAPGEF3 binds RAPGEF5, KCND3, and LRPAP1. 1 / 1
| 1
sparser
"Proteomic analysis of proteins coimmunoprecipitated with Kv4.3 revealed that Kv4.3 is associated with Rap guanine nucleotide exchange factors MR-GEF and EPAC-1."
17725712
KCND3 affects LBR
1 |
KCND3 binds LBR. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects KCN
| 1
KCN binds KCND3. 1 / 1
| 1
sparser
"We used well-characterized mouse monoclonal antibodies against the Kv4.3 and potassium channel interacting protein (KChIP) 1 subunits of A-type Kv channels, and antibodies against different interneuron markers in single- and double-label immunohistochemistry experiments to analyze the expression patterns of Kv4.3 and KChIP1 in hippocampal Ammon's horn (CA1) neurons."
18495361
KCND3 affects K V 4.3 channel kinetics
| 1
KCND3 activates K V 4.3 channel kinetics. 1 / 1
| 1
reach
"In conclusion, two novel BrS related mutations in the KCND3 gene were found to cause a gain-of-function of I to by altering K V 4.3 channel kinetics and membrane protein expression."
26016905
KCND3 affects HSPA8
1 |
HSPA8 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects HSPA5
1 |
HSPA5 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects HNRNPF
1 |
HNRNPF binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects HNRNPD
| 1
HNRNPD binds KCND3. 1 / 1
| 1
sparser
"Thus, to examine the mechanisms underlying Ang-II redox signaling, we turned to the Ang II-induced CaMKII activation shown previously to downregulate the Kv4.3 K + channel, which is produced by mRNA destabilization induced by AUF1 protein binding to the Kv4.3 3′ untranslated region (3′ UTR) in response to CaMKII phosphorylation xref xref xref ."
27079272
KCND3 affects G3BP1
1 |
G3BP1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects EWSR1
1 |
EWSR1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects EMD
1 |
EMD binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects DDB1
1 |
DDB1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects CUX1
1 |
CUX1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects CNBP
1 |
CNBP binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects CIRBP
| 1
CIRBP binds KCND3. 1 / 1
| 1
sparser
"We speculate that the mutation may disrupt the interaction of CIRP protein with KCND3 mRNAs, increasing the translation efficiency which leads to an upregulation of protein levels of K v 4.3 subunits."
29383177
KCND3 affects CDK1
1 |
CDK1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects Ala-Pro
| 1
KCND3 activates Ala-Pro. 1 / 1
| 1
reach
"Increased expression of KCND3, encoding a potassium voltage gated channel conducting the transient outward potassium current (I to1), promotes a more mature AP shape [48]."
25771005
KCND3 affects AUP1
1 |
KCND3 binds AUP1. 1 / 1
1 |
biogrid
No evidence text available
17725712
KCND3 affects AGT
| 1
AGT binds KCND3. 1 / 1
| 1
sparser
"Kv4.3 has been previously associated with AngII signaling in the heart xref and its expression in the RVLM is also down-regulated in the LPS model of hypertension xref ."
30354763
KCND3 affects 4-aminopyridine
| 1
KCND3 activates 4-aminopyridine. 1 / 1
| 1
reach
"KCNE2 can modulate the function of other ion channels XREF_BIBR, XREF_BIBR, including the 4-aminopyridine (4-AP)-sensitive rapidly activated, transient outward potassium current I A, which is mediated by the KCND3 gene-product, Kv4.3 XREF_BIBR."
22880098
KCN affects KCND3, KCNE5, KCNJ2, KCNJ5, and KCNJ8
| 1
KCN binds KCND3, KCNE5, KCNJ2, KCNJ5, and KCNJ8. 1 / 1
| 1
sparser
"It is probable that these polymorphisms may be correlated with the sensitivity of the SUNDS with the influence of environmental conditions, ethnic-specificity, individual state, and interaction with other genes such as KCND3 , KCNJ5 , KCNJ8 , KCNJ2 and KCNE5 which are also potassium channel genes related with LQTS and even genes of other cardiac ion channels."
23890619
KCN affects KCND3
| 1
KCN binds KCND3. 1 / 1
| 1
sparser
"We used well-characterized mouse monoclonal antibodies against the Kv4.3 and potassium channel interacting protein (KChIP) 1 subunits of A-type Kv channels, and antibodies against different interneuron markers in single- and double-label immunohistochemistry experiments to analyze the expression patterns of Kv4.3 and KChIP1 in hippocampal Ammon's horn (CA1) neurons."
18495361
IL1RL1 affects KCND3, and KIF22
| 1
IL1RL1 binds KCND3 and KIF22. 1 / 1
| 1
sparser
"Taken together, our findings reveal a novel (to our knowledge) role of the T1 domain in suppressing Kv4 CSI, and that KChIP4a KID directly interacts with the T1 domain to facilitate Kv4.3 CSI, thus leading to inhibition of channel function."
25185545
Histone_H3 affects KCND3
| 1
Histone_H3 increases the amount of KCND3. 1 / 1
| 1
reach
"Inducible cardiac ablation of PAX interacting protein 1 (PTIP), a key component of the histone H3 lysine 4 (H3K4me) complex, for example, has been demonstrated to increase the transcript expression levels of the genes, Kcnip2, Kcnd2 and Kcnd3, encoding I to, f channel subunits [XREF_BIBR]."
26391345
HSPA8 affects KCND3
1 |
HSPA8 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
HSPA5 affects KCND3
1 |
HSPA5 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
HSPA affects KCND3, and KCNH2
| 1
HSPA binds KCND3 and KCNH2. 1 / 1
| 1
sparser
"In addition, Hsp70 interacted with hERG and Kv4.3 respectively, and formed complexes with hERG and Kv4.3."
29259226
HNRNPF affects KCND3
1 |
HNRNPF binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
HNRNPD affects KCND3
| 1
HNRNPD binds KCND3. 1 / 1
| 1
sparser
"Thus, to examine the mechanisms underlying Ang-II redox signaling, we turned to the Ang II-induced CaMKII activation shown previously to downregulate the Kv4.3 K + channel, which is produced by mRNA destabilization induced by AUF1 protein binding to the Kv4.3 3′ untranslated region (3′ UTR) in response to CaMKII phosphorylation xref xref xref ."
27079272
GNPTAB affects KCND2, KCND3, and KCNIP2
| 1
KCNIP2 binds GNPTAB, KCND2, and KCND3. 1 / 1
| 1
sparser
"Biochemical studies suggest that mouse ventricular I(to,f) channels reflect the heteromeric assembly of Kv4.2 and Kv4.3 with the accessory subunits, KChIP2 and Kvbeta1, and that Kv4.2 is the primary determinant of regional differences in (mouse ventricular) I(to,f) densities."
16293790
G3BP1 affects KCND3
1 |
G3BP1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
FOXH1 affects KCND3
| 1
FOXH1 inhibits KCND3. 1 / 1
| 1
sparser
"Single Ala516 mutation abolished the acceleration of Kv4.3 fast component inactivation and decrease in Kv4.3 current density by p90RSK ( xref ); single Ala550 mutation abolished the acceleration of Kv4.3 slow component inactivation and decrease in Kv4.3 current density by p90RSK ( xref )."
18599872
EWSR1 affects KCND3
1 |
EWSR1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
EMD affects KCND3
1 |
EMD binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
EGFR affects KCND3
1 |
EGFR phosphorylates KCND3 on Y136. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
DPP6 affects KCND2, and KCND3
| 1
DPP6 binds KCND2, KCND2, and KCND3. 1 / 1
| 1
sparser
"It is interesting that the gradient matches the patterned distribution of Kv4.2 and not that of Kv4.3 since it has been suggested that, in neurons expressing predominantly Kv4.2 or Kv4.3 subunits, DPPX may form complexes preferentially with Kv4.2, whereas DPP10 with Kv4.3 ( Zagha et al., 2005 )."
16764835
DLG1 affects KCND3, and NAV1
| 1
NAV1 binds DLG1 and KCND3. 1 / 1
| 1
sparser
"It is conceivable that this mutation could affect DLG1-Kv4.3 or DLG1-NaV1.5 interactions, modulating their functions and favoring susceptibility for arrhythmias."
28750076
DDB1 affects KCND3
1 |
DDB1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
CUX1 affects KCND3
1 |
CUX1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
CREB1 affects KCND3
| 1
CREB1 decreases the amount of KCND3. 1 / 1
| 1
reach
"Long-term pacing down-regulates nuclear CREB1, which leads to reduced expression of KCND3 and KCNIP2, the main components of potassium channel contribution to transient outward potassium current in ventricular cardiomyocytes XREF_BIBR, XREF_BIBR."
20407090
CNBP affects KCND3
1 |
CNBP binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
CIRBP affects KCND3
| 1
CIRBP binds KCND3. 1 / 1
| 1
sparser
"We speculate that the mutation may disrupt the interaction of CIRP protein with KCND3 mRNAs, increasing the translation efficiency which leads to an upregulation of protein levels of K v 4.3 subunits."
29383177
CDK1 affects KCND3
1 |
CDK1 binds KCND3. 1 / 1
1 |
biogrid
No evidence text available
17725712
CALM affects CAMK2_complex, and KCND3
| 1
CALM binds CAMK2_complex and KCND3. 1 / 1
| 1
sparser
"We have recently demonstrated that in vivo Kv4.3 transfection in LV ventricular myocytes in the normal mice significantly inhibited CaMKII activity by direct binding to the CaM binding sites and forming a CaMKII-Kv4.3 molecular complex [ xref ]."
29262619
AUP1 affects KCND3
1 |
KCND3 binds AUP1. 1 / 1
1 |
biogrid
No evidence text available
17725712
AOX1 affects KCND3
| 1
AOX1 inhibits KCND3. 1 / 1
| 1
sparser
"Raloxifene inhibited Kv4.3 channels by interacting with their open state during depolarization and with the closed state at subthreshold potentials."
25231973
AOPEP affects KCND3, and MBTPS1
| 1
AOPEP binds MBTPS1 and KCND3. 1 / 1
| 1
sparser
"Mutation of Tyr-174 or Phe-218 on KChIP3 abolished the enhancement of Kv4.3 site 1 binding in the apo-state, highlighting the role of these residues in drug and K4.3 binding."
25228688
AGT affects KCND3
| 1
AGT binds KCND3. 1 / 1
| 1
sparser
"Kv4.3 has been previously associated with AngII signaling in the heart xref and its expression in the RVLM is also down-regulated in the LPS model of hypertension xref ."
30354763
3,3',5-triiodo-L-thyronine affects KCND3
| 1
3,3',5-triiodo-L-thyronine increases the amount of KCND3. 1 / 1
| 1
reach
"T3 stimulation enhanced KCND2 and KCND3 expression and decreased KCNA4 transcription, while KCNIP2 remained unaffected."
19171649