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phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading

KCNC3 affects SCA13
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KCNC3 activates SCA13. 6 / 6
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"SCA13 is caused by mutations in the KCNC3 voltage gated potassium channel."
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"SCA13 is caused by mutations in the KCNC3 gene, which encodes a voltage gated potassium channel (Kv3.3) that is highly enriched in cerebellum."
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"SCA13 (prevalence : < 1/1000,000) is caused by point mutations in the KCNC3 gene (encoding K v 3.3 channels), which affect channel function by gain- and loss-of-function mechanisms."
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"82Mutations in the voltage gated potassium channel KCNC3 (Kv3.3) lead to SCA13."
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"SCA13 is caused by mutations in the KCNC3 gene, which encodes a voltage gated K+ channel (Kv3.3) highly enriched in the cerebellum."
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"Therefore, we conclude that we have identified at least one novel pathogenic mutation in KCNC3 that cause SCA13 and two additionally potential SCA13 mutations."
Mutated KCNC3 activates SCA13. 3 / 3
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"SCA13 caused by KCNC3 mutations may present with deep sensory loss and cognitive impairment in addition to cerebellar ataxia."
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"A KCNC3 mutation causes a neurodevelopmental, non progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking."
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"Our present data support the notion that SCA13 is a rare ataxia and that KCNC3 mutations causing SCA13 have arisen in a number of ethnic groups."
KCNC3 affects HAX1
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sparser
"Our data indicate that Hax-1 interacts with the C-terminal domain of Kv3.3 and becomes enriched at the cell cortex."
sparser
"Although Hax-1 binds G592R Kv3.3, its ability to trigger Arp2/3-dependent actin nucleation and to link N-type inactivation to the cytoskeleton is impaired when bound to this mutant channel."
sparser
"The interaction between Kv3.3 and Hax-1 provides potential links between SCA13 mutations and degeneration of neurons such as cerebellar Purkinje cells."
sparser
"The effects of Kv3.3 on the actin cytoskeleton are mediated by the binding of the cytoplasmic C-terminus of Kv3.3 to Hax-1, an anti-apoptotic protein that regulates actin nucleation through Arp2/3."
sparser
"Moreover, effects of cortical Kv3.3-Hax-1 interactions are likely to be abolished in disease-causing mutations that prevent trafficking of Kv3.3 to the plasma membrane ( Gallego-Iradi et al., 2014 )."
PKC affects KCNC3
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PKC phosphorylates KCNC3. 3 / 3
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rlimsp
"Elimination of the first 78 amino acids of the N terminus of Kv3.3 produced noninactivating currents suggesting that PKC modulates N-type inactivation, potentially by phosphorylation of sites in this region."
sparser
"Computer simulations of model neurons suggest that phosphorylation of Kv3.3 by PKC may allow neurons to maintain action potential height during stimulation at high frequencies, and may therefore contribute to stimulus-induced changes in the intrinsic excitability of neurons such as those of the auditory brainstem."
rlimsp
"Computer simulations of model neurons suggest that phosphorylation of Kv3.3 by PKC may allow neurons to maintain action potential height during stimulation at high frequencies, and may therefore contribute to stimulus-induced changes in the intrinsic excitability of neurons such as those of the auditory brainstem."
PKC phosphorylates KCNC3 on S9. 1 / 1
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rlimsp
"Elimination of the first 78 amino acids of the N terminus of Kv3.3 produced noninactivating currents suggesting that PKC modulates N-type inactivation, potentially by phosphorylation of sites in this region. To identify potential phosphorylation sites, we investigated the response of channels in which serines in this N-terminal domain were subjected to mutagenesis. Our results suggest that serines at positions 3 and 9 are potential PKC phosphorylation sites."
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KCNC3 binds voltage-gated potassium channel.
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HOMER3 binds KCNC1, KCNC3, and voltage-gated potassium channel. 1 / 1
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sparser
"In fact, SynDIG4 appeared to preferentially interact with the voltage-gated potassium channel subunits KCNC1 and KCNC3 and the post-synaptic scaffolding protein Homer3 in the cerebellum."
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"A rare form of dominantly inherited ataxia, SCA13 is caused by mutations in the KCNC3 gene encoding the voltage gated potassium channel protein, Kv3.3."
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"Sectioning these eyes to uncover the arrangement of photoreceptor cells within each ommatidium revealed that expression of LacZ or KCNC3 WT did not perturb the differentiation or organization of the photoreceptor cells (XREF_FIG, bottom row)."
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"Expression of KCNC3 R420H, however, caused aberrant differentiation of photoreceptor cells (XREF_FIG, bottom row, yellow arrowheads) and abnormal cell polarity (red lines)."
KCNC3 affects SCA
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KCNC3 binds SCA.
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sparser
"For example, some forms of SCA, such as SCA13, SCA14 and SCA28 [ xref ; xref ; xref ; xref ], begin in childhood and/or early adult life, progress very slowly and may be associated with a normal lifespan."
KCNC3 activates SCA.
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KCNC3 activates SCA. 1 / 1
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"Taken together, these data suggest that mutations in KCNC3 may cause SCA both by gain- and loss-of-function mechanisms."
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Transcriptionally active hsa-miR-939-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-874-5p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-7974 decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-7110-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-7108-5p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-7108-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-6892-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-6845-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-6783-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-6769b-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-6759-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-6742-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-6736-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-663b decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
Hsa-miR-637 affects KCNC3
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Transcriptionally active hsa-miR-637 decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-6069 decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4793-5p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4749-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4747-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4723-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4707-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4448 decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4438 decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4433a-5p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4267 decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-361-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-3183 decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-215-5p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-192-5p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-136-5p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-1343-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-1226-3p decreases the amount of KCNC3. 1 / 1
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biopax:mirtarbase
No evidence text available
Filament affects KCNC3
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sparser
"In addition, Kv3.3 channel interactions with actin filaments appeared to be significantly decreased ( Figures 6 B and 6D; −45.1% ± 4.2%)."
SCA affects KCNC3
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sparser
"For example, some forms of SCA, such as SCA13, SCA14 and SCA28 [ xref ; xref ; xref ; xref ], begin in childhood and/or early adult life, progress very slowly and may be associated with a normal lifespan."
NOG affects KCNC3
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Transcriptionally active NOG decreases the amount of KCNC3. 1 / 1
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biopax:ctd
No evidence text available
KCNC3 affects filament
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sparser
"In addition, Kv3.3 channel interactions with actin filaments appeared to be significantly decreased ( Figures 6 B and 6D; −45.1% ± 4.2%)."
KCNC3 affects Kv3.3 currents
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KCNC3 inhibits Kv3.3 currents. 1 / 1
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"Mutations in KCNC3 are presumed to suppress Kv3.3 currents in dominant negative manner."
KCNC3 affects EGFR
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KCNC3-R423H inhibits EGFR. 1 / 1
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"Negative co-immunoprecipitation data confirms that the intracellular retention of EGFR by KCNC3 R423H is not likely to be dependent on a direct protein-to-protein interactions."
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KCNC3-R420H activates Cell Polarity. 1 / 1
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"Expression of KCNC3 R420H, however, caused aberrant differentiation of photoreceptor cells (XREF_FIG, bottom row, yellow arrowheads) and abnormal cell polarity (red lines)."
KCNC3 affects CTTN
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sparser
"We found that cortactin associates with Kv3.3 and is localized to the cell cortex along with Hax-1."
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sparser
"To test whether the interaction of Kv3.3 with Arp2/3 influences actin nucleation, we carried out triple channel confocal imaging of actin filaments, Arp2/3, and the Kv3.3 channel in untransfected CHO cells and in cells transiently or stably expressing wild-type Kv3.3 ( Figures 1 B–1E and S1 A)."
KCNC3 affects A-type K
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KCNC3 activates A-type K. 1 / 1
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"In expression systems, the channels produced by the expression of Kcnc1 and Kcnc2 produce delayed rectifier K + currents, whereas the expression of Kcnc3 and Kcnc4 produce inactivating A-type K + currents."
HOMER3 affects KCNC1, KCNC3, and voltage-gated potassium channel
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HOMER3 binds KCNC1, KCNC3, and voltage-gated potassium channel. 1 / 1
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sparser
"In fact, SynDIG4 appeared to preferentially interact with the voltage-gated potassium channel subunits KCNC1 and KCNC3 and the post-synaptic scaffolding protein Homer3 in the cerebellum."
HFBF affects KCNC3
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HFBF inhibits KCNC3. 1 / 1
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"KCNC3, KCNA6, KCNQ2, KCNE1, KCNN1, and KCTD19 genes encode potassium voltage gated channels and are downregulated by the HFBF (XREF_TABLE)."
GAD1 affects GAD2, and KCNC3
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GAD1 binds GAD2 and KCNC3. 1 / 1
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sparser
"► Kv3.1b and Kv3.3 expression was studied in dorsal horn GABAergic interneurones. ► Kv3.1b or Kv3.3 was most abundantly expressed in laminae I–III. ► Kv3.1b but not Kv3.3 was associated with GAD65 and GAD67 neurones. ► Capsaicin-induced c-fos expression was localized mainly to GAD65-GFP interneurones."
EGFR affects KCNC3
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EGFR activates KCNC3-R423H. 1 / 1
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"Because the profound KCNC3 R423H eye phenotype can be almost completely rescued by elevated Egfr expression and R423H and Egfr-RNAi co-expression accentuates wing malformations, a direct or indirect association is strongly implicated between KCNC3 and Egfr, as well as a link between this potent growth factor receptor and cerebellar hypoplasia."
DSPP affects KCNC3
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DSPP activates KCNC3-R423H. 1 / 1
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"Similarly, KCNC3 R423H self-cross, driven by dpp-Gal4 in the wing, led to disruption of veins L2, L3, and ACV in the wing (XREF_FIG compared to XREF_FIG), whereas co-expression of KCNC3 WT with KCNC3 R423H resulted in a phenotype similar to KCNC3 R423H alone (XREF_FIG compared to XREF_FIG)."
CTTN affects KCNC3
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sparser
"We found that cortactin associates with Kv3.3 and is localized to the cell cortex along with Hax-1."
BMP2 affects KCNC3
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BMP2 increases the amount of KCNC3. 1 / 1
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"BMP-2 (100 nM for 18-24 h) significantly (> 2-fold) upregulated mRNA expression of KCNA5, KCNA7, KCNA10, KCNC3, KCNC4, KCNF1, KCNG3, KCNS1, and KCNS3 but downregulated (at least 2-fold) KCNAB1, KCNA2, KCNG2, and KCNV2."
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sparser
"To test whether the interaction of Kv3.3 with Arp2/3 influences actin nucleation, we carried out triple channel confocal imaging of actin filaments, Arp2/3, and the Kv3.3 channel in untransfected CHO cells and in cells transiently or stably expressing wild-type Kv3.3 ( Figures 1 B–1E and S1 A)."