"PKA phosphorylation of Kv3.2 lowered the maximum firing frequency of inhibitory neurons, which in turn negatively modulated high-frequency population oscillations recorded in principal cell layers."
"In this study, we observed a significant DMR association of KCNC2 using genome-wide DNA methylome profiles in our T2D-discordant monozygotic twin model."
"Although the effects of NO on Kv3.1 and Kv3.2 channels require PKG activity, two observations suggest that they are not mediated by phosphorylation of channel proteins: (a) the reagents affect both Kv3.2 and Kv3.1 channels, although only Kv3.2 proteins have a putative PKA-PKG phosphorylation site, and (b) mutation of the PKA-PKG phosphorylation site in Kv3.2 does not interfere with the effects of NO or cGMP."
"Thus, the lack of Kcnc1 and Kcnc2 genes appeared to eliminate the day and night difference in spontaneous activity in the SCN by reducing the firing rate during the mid-day peak."
"In this study, we observed a significant DMR association of KCNC2 using genome-wide DNA methylome profiles in our T2D-discordant monozygotic twin model."
"We recorded the FDR current from SCN neurons and found that the loss of Kcnc2 modestly reduced the magnitude of the FDR current while the loss of both Kcnc1 and Kcnc2 resulted in a dramatically reduced current (XREF_FIG)."
"Kv3.2c, the only one of three C-terminal splice variants of the GIRK Kv3.2 which binds to the PDZ protein SAP-97, also requires SAP-97 for activation by G-βγ."
"In contrast, seizure-induced increase of NRSF levels markedly augmented NRSF binding to genes such as Calb1, Glra2, Grin2A, Hcn1, and Kcnc2 , where binding was moderate in the naive hippocampus."