INDRA statements for KCNC1

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
Pyraclofos affects KCNC1
| 3
Pyraclofos activates KCNC1. 3 / 3
| 3
sparser
"FSIs are specifically adapted to fast firing by the expression of a unique selection of ion channels including rapid kinetics voltage‐activated potassium channel Kv3.1 subtype (Espinosa et al . xref , Gu et al . xref , Yanagi et al . xref ), and the voltage‐activated sodium Nav1.1 channels that have recently been suggested as a therapeutic target for cognitive disorders in schizophrenia (Jensen et al . xref )."
27364459
sparser
"Here, we transplanted homologous amino acid motifs from the tetrameric voltage-activated potassium channel Kv3.1 to the monomeric VSD of Ciona intestinalis voltage-sensitive phosphatase (Ci-VSP) to explore which portions of Kv3.1 subunits depend on the tetrameric structure of Kv channels and which properties of Kv3.1 can be transferred to the monomeric Ci-VSP scaffold."
22947928
sparser
"The Shaw-like voltage-activated potassium channel Kv3.1 is expressed in neurons that generate rapid trains of action potentials."
7472324
KCNC1 affects ANK3
1 1 | 1
ANK3 binds KCNC1. 2 / 2
1 1 |
hprd
No evidence text available
12805291
biogrid
No evidence text available
12805291
SLC25A4 binds ANK3 and KCNC1. 1 / 1
| 1
sparser
"Thus, the AnkG MB domain binds to the Kv3.1 T1-binding site in KIF5B tail."
24412576
NOG affects KCNC1
2 |
Transcriptionally active NOG decreases the amount of KCNC1. 2 / 2
2 |
biopax:ctd
No evidence text available
27188386
biopax:ctd
No evidence text available
27188386
KIF5 affects KCNC1
| 2
KCNC1 binds KIF5. 2 / 2
| 2
sparser
"Since Kv3.1 directly binds to KIF5, AnkG is not required for axonal transport of Kv3.1 channels."
24412576
sparser
"First, we have identified a novel interaction between Kv3.1 and KIF5, confirmed by immunoprecipitation from mouse brain lysates and by pull down assays with exogenously-expressed proteins."
21106837
KCNC1 affects FMR1
| 2
FMR1 binds KCNC1. 2 / 2
| 2
sparser
"Recent studies have shown that FMRP interacts with Kv3.1 mRNA and that dysregulated Kv3.1b translation in a variety of brain regions could be responsible of many symptoms of human FXS."
31885726
sparser
"Therefore, the finding that FMRP interacts with Kv3.1 mRNA in synaptosomes raises the possibility that dysregulated Kv3.1b translation in a variety of brain regions is a common etiology for many of the symptoms of human FXS."
20685971
Valproic acid affects KCNC1
| 1
Valproic acid decreases the amount of KCNC1. 1 / 1
| 1
reach
"In contrast, forebrain mRNA levels of Kcnc1 coding for K v 3.1 were significantly decreased by ~ 40% in VPA mice (p = 0.0114)."
28066177
Hsa-miR-92a-3p affects KCNC1
1 |
Transcriptionally active hsa-miR-92a-3p decreases the amount of KCNC1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-582-5p affects KCNC1
1 |
Transcriptionally active hsa-miR-582-5p decreases the amount of KCNC1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23295946
Hsa-miR-582-3p affects KCNC1
1 |
Transcriptionally active hsa-miR-582-3p decreases the amount of KCNC1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23295946
Hsa-miR-335-5p affects KCNC1
1 |
Transcriptionally active hsa-miR-335-5p decreases the amount of KCNC1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18185580
Voltage_gated_ion_channels affects KCNC1
| 1
Voltage_gated_ion_channels binds KCNC1. 1 / 1
| 1
sparser
"The interaction domain (ID), identified by Y2HS, lies within the C-terminal portion, a region conserved in the Kif5 subfamily ( Figure S2 A) and previously found to interact with Kv3.1 voltage-gated K + channels to mediate their transport to axons ( Xu et al., 2010 )."
22705394
PARVA affects KCNC1
| 1
PARVA binds KCNC1. 1 / 1
| 1
sparser
"In the OD interaction network, NCK2 and KCNG2 showed many interacting partners, having common interactions with PARVA and KCNC1 , respectively ( xref )."
26267224
KCNC1 affects thiocyanate
| 1
KCNC1 inhibits thiocyanate. 1 / 1
| 1
reach
"Thus, the lack of Kcnc1 and Kcnc2 genes appeared to eliminate the day and night difference in spontaneous activity in the SCN by reducing the firing rate during the mid-day peak."
21414897
KCNC1 affects potassium(1+)
| 1
KCNC1 activates potassium(1+). 1 / 1
| 1
reach
"Therefore, we utilized TEA (10 mM external concentration) to block selectively most of the delayed rectifier K+ current contributed by the NGK2 channel in differentiated NG108-15 cells (Yokoyama et al., 1989)."
8261514
KCNC1 affects cell population proliferation
| 1
KCNC1 inhibits cell population proliferation. 1 / 1
| 1
reach
"For example, it has been shown that Kv1.3 (KCNA3) and Kv3.1 (KCNC1) blockade increases neural progenitor cell proliferation [XREF_BIBR]; likewise, induction of H + flux induces regeneration of a complex appendage [XREF_BIBR] and blockade of gap junction mediated signals results in the formation of a complete, properly patterned head in a planarian tail blastema [XREF_BIBR]."
19406249
KCNC1 affects Voltage_gated_ion_channels
| 1
Voltage_gated_ion_channels binds KCNC1. 1 / 1
| 1
sparser
"The interaction domain (ID), identified by Y2HS, lies within the C-terminal portion, a region conserved in the Kif5 subfamily ( Figure S2 A) and previously found to interact with Kv3.1 voltage-gated K + channels to mediate their transport to axons ( Xu et al., 2010 )."
22705394
KCNC1 affects PARVA
| 1
PARVA binds KCNC1. 1 / 1
| 1
sparser
"In the OD interaction network, NCK2 and KCNG2 showed many interacting partners, having common interactions with PARVA and KCNC1 , respectively ( xref )."
26267224
KCNC1 affects N-methyl-D-aspartic acid
| 1
KCNC1 inhibits N-methyl-D-aspartic acid. 1 / 1
| 1
reach
"So the lack of Kcnc1 and Kcnc2 genes also reduced the ability of NMDA to increase firing rate of SCN neurons during the night."
21414897
KCNC1 affects KLRK1
| 1
KCNC1 inhibits KLRK1. 1 / 1
| 1
reach
"The percentage of pMSCs that expressed ligands for the NK activating receptors, DNAM-1 and NKG2D, and for the NK inhibitory receptors, CD94 and NGK2, is shown in Table XREF_TABLE."
30728068
KCNC1 affects DLG1
1 |
DLG1 binds KCNC1. 1 / 1
1 |
biogrid
No evidence text available
19213956
KCNC1 affects CD226
| 1
KCNC1 inhibits CD226. 1 / 1
| 1
reach
"The percentage of pMSCs that expressed ligands for the NK activating receptors, DNAM-1 and NKG2D, and for the NK inhibitory receptors, CD94 and NGK2, is shown in Table XREF_TABLE."
30728068
KCNC1 affects CAMK2A
1 |
CAMK2A binds KCNC1. 1 / 1
1 |
biogrid
No evidence text available
19213956
HOMER3 affects KCNC1, KCNC3, and voltage-gated potassium channel
| 1
HOMER3 binds KCNC1, KCNC3, and voltage-gated potassium channel. 1 / 1
| 1
sparser
"In fact, SynDIG4 appeared to preferentially interact with the voltage-gated potassium channel subunits KCNC1 and KCNC3 and the post-synaptic scaffolding protein Homer3 in the cerebellum."
26660156
DLG1 affects KCNC1
1 |
DLG1 binds KCNC1. 1 / 1
1 |
biogrid
No evidence text available
19213956
CAMK2A affects KCNC1
1 |
CAMK2A binds KCNC1. 1 / 1
1 |
biogrid
No evidence text available
19213956
BMP2 affects KCNC1
| 1
BMP2 decreases the amount of KCNC1. 1 / 1
| 1
reach
"The real-time PCR experiments show that KCNA1 to 2, KCNA4, KCNB1 to 2, and KCNC1 expression levels were slightly decreased by BMP-2 treatment in human PASMC, as were those of KCNB1 and KCNB3 regulatory subunits."
23733654
APP affects KCNC1
1 |
Transcriptionally active APP decreases the amount of KCNC1. 1 / 1
1 |
biopax:ctd
No evidence text available
21298039
ANK3 affects KCNC1, and SLC25A4
| 1
SLC25A4 binds ANK3 and KCNC1. 1 / 1
| 1
sparser
"Thus, the AnkG MB domain binds to the Kv3.1 T1-binding site in KIF5B tail."
24412576