"While no single SNP produced significant evidence for association in the Finnish case–control sample, SNP × SNP epistasis analysis of the 66 SNPs selected for replication detected a significant interaction between KCNB2SNP rs1431656 on chromosome 8q13.3 and CACNB2 SNP rs7076100 on chromosome 10p12.33 (point-wise P = 0.0000199; global P = 0.022)."
"The
top SNP associations were: for LV diastolic dimension, a SNP associated with SLIT2 gene; for LV systolic dimension, a SNP associated
with KCNB2 gene; and for LV mass, and left atrial size, SNPs
associated with FAM5C gene."
"Interestingly, a SNP × SNP epistasis analysis of the 66 replication SNPs in the Finnish case–control sample detected an interaction between KCNB2SNP rs1431656 on chromosome 8q13.3 and CACNB2 SNP rs7076100 on chromosome 10p12.33 (point-wise P = 0.0000199), which remained significant after conservatively correcting for all 2145 possible interaction tests [i.e. treating the 66 replication SNPs as independent] (global P = 0.042)."
"By searching for two-way interactions in a panel of candidate genes implicated in memory, we observed an additive interaction between KCNB2SNP rs7006287 and KCNH5SNP rs243146."
"Although no variant remained significant after adjusting for multiple testing nor produced consistent evidence for association across all cohorts, a significant epistatic interaction between KCNB2SNP rs1431656 (chromosome 8q13.3) and CACNB2SNP rs7076100 (chromosome 10p12.33) (pointwise P = 0.00002; global P = 0.02) was observed in the Finnish case–control sample."
"Comparative two-electrode voltage clamp analysis in oocytes between Kv2.2 and Kv2.1 shows that Kv2.2 interacts only with syntaxin 1A and, in contrast to Kv2.1, it does not interact with the syntaxin 1A/SNAP-25 complex and hence is not sensitive to the assembly/disassembly state of the complex."
"MicroRNA-1 Accelerates the Shortening of Atrial Effective Refractory Period by Regulating KCNE1 and KCNB2 Expression : An Atrial Tachypacing Rabbit Model."
"However, knockdown of KCNB1, but not KCNB2, impairs depolarization induced exocytosis in human beta-cells (XREF_FIG), which is consistent with the divergent C-terminal homology and an inability of Kv2.2 to bind the syntaxin 1A/SNAP -25 complex."
"In beta-cells from donors with T2D, we find that Kv currents are similar to those from ND donors (XREF_FIG), although knockdown of either KCNB1 (XREF_FIG) or KCNB2 (XREF_FIG) now fail to inhibit Kv currents."
"By searching for two-way interactions in a panel of candidate genes implicated in memory, we observed an additive interaction between KCNB2SNP rs7006287 and KCNH5SNP rs243146."
"Several regions were identified for these techniques that harbored genes, such as kind1 and chp2 , which have been associated with growth-related traits or the kcnb2 gene related to immune system in Atlantic salmon, making them particularly relevant in the context of aquaculture."
"Although no variant remained significant after adjusting for multiple testing nor produced consistent evidence for association across all cohorts, a significant epistatic interaction between KCNB2SNP rs1431656 (chromosome 8q13.3) and CACNB2SNP rs7076100 (chromosome 10p12.33) (pointwise P = 0.00002; global P = 0.02) was observed in the Finnish case–control sample."