INDRA statements for KCNB1

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Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
Syntaxin affects KCNB1
| 26
KCNB1 binds syntaxin. 22 / 22
| 22
sparser
"Similarly the voltage sensitive potassium channel Kv2.1 can also interact with syntaxin 1 ( xref , xref )."
19251047
sparser
"Firstly, in view of the proposal that syntaxin lines the fusion pore xref , the Kv2.1-syntaxin interaction may promote full collapse fusion, which induces complete release, in place of the incomplete release associated with kiss and run exocytosis."
18167541
sparser
"Next, in an effort to evaluate the involvement of the interaction between endogenous Kv2.1 and syntaxin in the Ca 2+ -regulated secretion from PC12 cells, we aimed to disrupt this interaction and to assay the impact on secretion."
18167541
sparser
"In any of these or other possible mechanisms, both our studies together provide strong evidence that the Kv2.1-syntaxin interaction exerts its effect on secretion after ATP-dependent priming of the vesicles."
18167541
sparser
"Secondly, in view of the demonstration that Kv2.1 preferentially binds the open conformation of syntaxin xref , the Kv2.1-syntaxin interaction may influence the equilibrium between the closed and open conformations of syntaxin."
18167541
sparser
"In the present study, we tested whether disrupting the interaction of Kv2.1 and syntaxin promoted the survival of cortical neurons following injury."
24928958
sparser
"Here, we further characterized the binding of native syntaxin from PC12 cells to the Kv2.1 peptides."
18167541
sparser
"Importantly, the physical interaction of Kv2.1 with syntaxin was shown to be involved in the facilitation of secretion from PC12 cells, which was independent of potassium currents."
18636750
sparser
"Thirdly, the Kv2.1-syntaxin interaction may influence the equilibrium between the reserve and the releasable pools of vesicles."
18167541
sparser
"Here, we show that Kv2.1-induced facilitation of release is not restricted to neuroendocrine cells, but also occurs in the somatic-vesicle release from dorsal-root-ganglion neurons and is mediated by direct association of Kv2.1 with syntaxin."
20484665
sparser
"Notably, in both studies, the impact of the Kv2.1-syntaxin interaction on secretion was studied under conditions in which K + ion efflux and membrane potential changes were either minimal (secretion from living cells elicited by increasing the extracellular K + concentration ; xref or irrelevant (secretion from cells with permeable plasma membranes; this study)."
18167541
sparser
"Thus, direct association of Kv2.1 with syntaxin promotes exocytosis."
17301173
sparser
"This study is a direct continuation of and complement to our previous study xref ; both studies strongly suggest that Kv2.1-syntaxin interaction causes an enhancement of the release of DCVs."
18167541
sparser
"We show that impairment of the interaction of syntaxin with endogenous Kv2.1 attenuates NE release."
18167541
sparser
"Given the proposed role for surface VAMP2 in the regulation of the vesicle cycle and the important role for the sustained Kv2.1 current in the regulation of dendritic calcium entry during high-frequency stimulation, the interaction of VAMP2 with Kv2.1 N terminus may contribute, alongside with the interaction of syntaxin with Kv2.1 C terminus, to the activity dependence of DCV release."
18542995
sparser
"The above Kv2.1-derived syntaxin-binding peptides were shown to compete for the in situ association of syntaxin with Kv2.1 in PC12 cells xref and, hence, were suited for this purpose."
18167541
sparser
"These results establish that binding of syntaxin to Kv2.1 is crucial for the manifestation of oxidant-induced apoptosis, and thereby reveal a potential new direction for therapeutic intervention in the treatment of neurodegenerative disorders."
24928958
sparser
"Moreover, we show that impairment of the syntaxin-Kv2.1 interaction during the triggering phase is responsible for the reduced release."
18167541
sparser
"Here a rational approach was applied to define the key molecular interactions between syntaxin and Kv2.1, some of which are shared with mammalian uncoordinated-18 (munc18)."
31308225
sparser
"Thus, we postulated that direct association of overexpressed Kv2.1 with syntaxin promotes exocytosis."
18167541
sparser
"Thus, the impact of Kv2.1-syntaxin interaction does not result from a change in the voltage-dependent gating of the channel, but rather reflects the effect of a direct interaction between the channel and the secretory machinery"
18167541
sparser
"We showed previously that the observed increase in K(+) currents is a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated process, and that the SNARE protein syntaxin binds directly to Kv2.1 channels."
24928958
SNAP receptor activity binds KCNB1 and syntaxin. 2 / 2
| 2
sparser
"In particular, syntaxin associates with the C-terminus of Kv2.1 ( xref ), raising the possibility that S800 phosphorylation facilitates SNARE-mediated insertion of Kv2.1 into the plasma membrane, a hypothesis that warrants further investigation."
23223293
sparser
"Kv2.1 protein associates with syntaxin to stabilize the t-SNARE (soluble N-ethylamaleimide-sensitive factor attachment protein receptor) protein complex; 2)."
21466805
SNAP25 binds KCNB1 and syntaxin. 1 / 1
| 1
sparser
"Of interest, Kv2.1 binds to both syntaxin and SNAP-25 in vitro and thus has been postulated to be directly involved in membrane fusion events ( xref ; xref )."
22648171
C2 binds KCNB1 and syntaxin. 1 / 1
| 1
sparser
"In the presence of Kv2.1-C2 that binds syntaxin weakly xref , xref there was a relatively small and statistically insignificant reduction of release ( xref )."
18167541
P38 affects KCNB1
| 2 2 17 2
P38 phosphorylates KCNB1.
| 2 2 15 1
P38 phosphorylates KCNB1. 15 / 15
| 2 1 12 1
sparser
"In previous studies [ xref , xref ], we reported that the phosphorylation of Kv2.1 by Src and p38 kinases is associated with oxidant-triggered apoptotic K + current surges in transfected CHO cells."
26115091
rlimsp
"Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1."
17360683
sparser
"Together, these data indicate that although NS5A1b can depress basal Kv2.1-mediated currents in neurons and in a recombinant expression system, as well as limit the apoptotic surge in neurons, it likely does not interfere with p38 phosphorylation of Kv2.1."
22745487
sparser
"Interestingly, NS5A inhibited oxidative stress-induced p38 MAPK phosphorylation of Kv2.1."
21168955
sparser
"Since this result suggested a different mechanism of action by the viral protein than that suggested by xref , we investigated the status of p38 phosphorylation of Kv2.1 in CHO cells expressing NS5A1b."
22745487
sparser
"The HCV NS5A protein mediated this effect by inhibiting oxidative stress-induced p38 MAPK phosphorylation of Kv2.1."
19717445
sparser
"In addition, a phospho-specific antibody for S800 detects a p38-dependent increase in Kv2.1 phosphorylation in apoptotic neurons and reveals phosphorylation of S800 in immunopurified channels incubated with active p38."
17360683
reach
"30 Even though the oligomerization and insertion mechanisms are thought to be uncoupled and to be active during distinct phases of the apoptotic process, 18 it is possible that integrins may indirectly affect the phosphorylation of KCNB1 by p38 in pathological conditions through their modulation of Src signaling."
28383553
sparser
"The phosphorylation of Kv2.1 by p38 MAPK occurs specifically at the S800 residue of the intracellular C-terminus [ xref ], while Src mainly phosphorylates an N-terminal residue, Y124 [ xref ]."
26115091
rlimsp
"Consequently, phosphorylation of Kv2.1 residue S800 by p38 leads to trafficking and membrane insertion during apoptosis, and remarkably, the absence of S800 phosphorylation is sufficient to prevent completion of the cell death program."
17360683
sparser
"This process is triggered by the phosphorylation of Kv2.1 by Src and p38 kinases at two distinct intracellular n- and c-terminal residues of the channel, Y124 and S800 ( xref , xref )."
22745487
sparser
"It was recently demonstrated that in response to oxidative stress, activated p38MAPK phosphorylates the Kv2.1 protein, which mediates an K + efflux with a concomitant induction of apoptosis ( xref , xref )."
23857585
sparser
"In an attempt to ascribe a function to the P2 motif, we previously reported that HCV attenuates outward K + currents mediated by the Kv2.1 channel in a P2 dependent manner ( xref ), whereby channel activity was found to be impaired by inhibition of p38MAPK phosphorylation of serine 800 (S800) in the C-terminal cytoplasmic domain of Kv2.1."
23857585
sparser
"Combining molecular, biochemical and electrophysiological techniques, we establish Src kinase as a critical upstream signaling modulator facilitating p38 MAPK phosphorylation of Kv2.1."
26115091
sparser
"Cysteine mutations influence p38 phosphorylation of Kv2.1."
26115091
P38 phosphorylates KCNB1 on S800. 3 / 3
| 1 3
sparser
"CXCR4-mediated neuronal apoptosis is dependent on p38 MAPK phosphorylation of Kv2.1 at S800."
23223293
sparser
"In cortical neurons, increased currents are triggered by dual phosphorylation of Kv2.1 by Src and p38 at channel residues Y124 and S800."
22745487
sparser
"We had previously shown that p38 phosphorylation of residue S800 on Kv2.1 was a critical step necessary for the insertion of new channels into the plasma membrane, underlying the apoptotic K + current surge ( xref , xref )."
22745487
P38 binds KCNB1.
| 2
P38 binds SRC and KCNB1. 1 / 1
| 1
sparser
"In previous studies [ xref , xref ], we reported that the phosphorylation of Kv2.1 by Src and p38 kinases is associated with oxidant-triggered apoptotic K + current surges in transfected CHO cells."
26115091
P38 binds IK and KCNB1. 1 / 1
| 1
sparser
"Taken together, these results suggest that gp120 induces hippocampal neuron apoptosis by enhancement of the Ik, which might be associated with increased Kv2.1 expression via the p38 MAPK pathway."
26393286
P38 activates KCNB1.
| 1
P38 activates KCNB1. 1 / 1
| 1
reach
"XREF_BIBR, XREF_BIBR Modulation of KCNB1 by p38 kinases has been shown to have a role in conditions, such as hepatitis C and cancer."
28383553
SRC affects KCNB1
1 2 1 2 | 3 1 12
SRC phosphorylates KCNB1.
1 1 1 | 3 1 11
SRC phosphorylates KCNB1. 12 / 12
| 2 1 10
sparser
"This process is triggered by the phosphorylation of Kv2.1 by Src and p38 kinases at two distinct intracellular n- and c-terminal residues of the channel, Y124 and S800 ( xref , xref )."
22745487
sparser
"However, a systematic analysis of the molecular mechanism of Kv2.1 channel phosphorylation by Src is lacking."
22106938
sparser
"Fortunately, most (~80%) of the Src phosphorylation of Kv2.1 occurs at this residue ( xref )."
22745487
rlimsp
"Accordingly, NS5A1b coexpression prevents phosphorylation of wild-type Kv2.1 by Src at Y124, but is unable to inhibit p38 phosphorylation of the channel at S800."
22745487
sparser
"This result led us to evaluate whether NS5A1b could prevent Src phosphorylation of Kv2.1."
22745487
rlimsp
"The actions of the viral protein are genotype-selective, as NS5A1a does not depress neuronal potassium currents nor inhibit Src phosphorylation of Kv2.1."
22745487
sparser
"This may be a potential pathway involving CK2 which indirectly downregulates Src phosphorylation of Kv2.1 via PP2A activation, and thus diminishes Kv2.1 activity under normal, steady-state conditions."
26472706
sparser
"The actions of the viral protein are genotype-selective, as NS5A1a does not depress neuronal potassium currents nor inhibit Src phosphorylation of Kv2.1."
22745487
sparser
"In previous studies [ xref , xref ], we reported that the phosphorylation of Kv2.1 by Src and p38 kinases is associated with oxidant-triggered apoptotic K + current surges in transfected CHO cells."
26115091
sparser
"We identified two novel Tyr sites of Src-dependent phosphorylation in Kv2.1 channels and showed that mutation of these sites to non-phosphorylatable residues results in blockage or decrease of the K + current enhancement that is normally observed in the presence of active Src and that these sites regulate the activities and the surface expression levels of the channel when Src is present."
22106938
sparser
"NS5A1b co-expression also inhibited this more modest Src-induced phosphorylation of Kv2.1(Y124F) (0.015 ± 0.004 r."
22745487
sparser
"NS5A1b modulates this process by interfering with the phosphorylation of Kv2.1 by Src."
22745487
SRC phosphorylates KCNB1 on Y128. 3 / 3
1 1 1 |
biopax:phosphositeplus
No evidence text available
hprd
No evidence text available
12615930
signor
"In the present study we show that an n-terminal tyrosine of kv2.1 (y124), which is a known target of src kinase, is critical for the apoptotic current surge..Kv2.1-mediated k+ currents are also enhanced during non-injurious conditions through direct phosphorylation of intracellular n-terminal residue tyrosine 124 (y124) by src kinase"
19622611
SRC phosphorylates KCNB1 on S800. 2 / 2
| 1 1
rlimsp
"In cortical neurons, increased currents are triggered by dual phosphorylation of Kv2.1 by Src and p38 at channel residues Y124 and S800."
22745487
sparser
"In cortical neurons, increased currents are triggered by dual phosphorylation of Kv2.1 by Src and p38 at channel residues Y124 and S800."
22745487
SRC binds KCNB1.
1 1 | 1
SRC binds KCNB1. 2 / 2
1 1 |
biogrid
No evidence text available
12615930
hprd
No evidence text available
12615930
P38 binds SRC and KCNB1. 1 / 1
| 1
sparser
"In previous studies [ xref , xref ], we reported that the phosphorylation of Kv2.1 by Src and p38 kinases is associated with oxidant-triggered apoptotic K + current surges in transfected CHO cells."
26115091
SRC activates KCNB1.
1 |
SRC activates KCNB1. 1 / 1
1 |
signor
"In the present study we show that an n-terminal tyrosine of kv2.1 (y124), which is a known target of src kinase, is critical for the apoptotic current surge..Kv2.1-mediated k+ currents are also enhanced during non-injurious conditions through direct phosphorylation of intracellular n-terminal residue tyrosine 124 (y124) by src kinase"
19622611
STX1A affects KCNB1
4 1 | 11
STX1A binds KCNB1. 11 / 11
4 1 | 6
sparser
"Here we demonstrate, using co-immunoprecipitation and immunocytochemistry analyses, the existence of a physical interaction in neuroendocrine cells between Kv2.1 and syntaxin 1A. Furthermore, using concomitant co-immunoprecipitation from plasma membranes and two-electrode voltage clamp analyses in Xenopus oocytes combined with in vitro binding analysis, we characterized the effects of these interactions on the Kv2.1 channel gating pertaining to the assembly/disassembly of the syntaxin 1A/SNAP-25 (target (t)-SNARE) complex."
12807875
sparser
"Syntaxin 1A alone binds strongly to Kv2.1 and shifts both activation and inactivation to hyperpolarized potentials."
12807875
sparser
"Kv2.1 interacts directly with syntaxin 1A, a plasma membrane t-SNARE component of the vesicle docking and fusion apparatus."
17609479
sparser
"This phenomenon relies on Kv2.1 binding to syntaxin 1A via 9 amino acids within the channel intrinsically disordered C terminus."
31308225
sparser
"Colocalization of KCNQ2 and syntaxin 1A at synaptic terminals suggests a role for their interaction in vesicle release, similar to the recently identified novel role for the syntaxin 1A-Kv2.1 interaction in the enhancement of dense-core vesicle release xref , xref ."
19675672
biogrid
No evidence text available
22411134
sparser
"Indeed, this is true in both rodent and human β-cells, in which we demonstrated that disruption of the Kv2.1–syntaxin 1A interaction impairs depolarization-induced exocytosis and insulin secretion ( xref )."
28607108
hprd
No evidence text available
12403834
biogrid
No evidence text available
15518587
biogrid
No evidence text available
22411134
biogrid
No evidence text available
15518587
SNAP25 binds STX1A and KCNB1. 2 / 2
| 2
sparser
"We have shown that Kv2.1 interacts with syntaxin 1A and SNAP-25 and, based on studies in oocytes, suggested a model of two distinct modes of interaction of syntaxin 1A and the complex syntaxin 1A/SNAP-25 with the C terminus of the channel."
16754785
sparser
"Expression of Kv2.1, SNAP-25, and syntaxin 1A was detected in human islet lysates by Western blot, and coimmunoprecipitation studies showed that heterologously expressed SNAP-25 and syntaxin 1A associate with Kv2.1."
12403834
STX1A binds KCNA1 and KCNB1. 1 / 1
| 1
sparser
"Studies have shown that Syntaxin 1A interacts with both Kv2.1 and Kv1.1 and modulates the firing frequency of the pre-synaptic membrane ( xref ; xref )."
21797886
STX1A binds KCNB1 and PCID:21618712. 1 / 1
| 1
sparser
"We have obtained evidence that syntaxin-1A physically interacts with Kv2.1 (the predominant Kv in beta-cells) and the sulfonylurea receptor subunit of beta-cell K(ATP) channel to modify their gating behaviors."
17878408
C1 binds STX1A and KCNB1. 1 / 1
| 1
sparser
"Previous in vitro binding studies, using immobilized glutathione S-transferase (GST) fusion peptides corresponding to the major cytoplasmic parts of Kv2.1 (depicted in xref ), showed that syntaxin 1A (syntaxin) binds Kv2.1 C-terminal C1 and C1a domains, but not the Kv2.1 N terminus xref ."
18167541
KCNB1 affects apoptotic process
| 2 14
KCNB1 activates apoptotic process.
| 2 12
KCNB1 activates apoptotic process. 12 / 12
| 2 12
reach
"Oxidant induced oligomerization of wild-type KCNB1 enhanced apoptosis in neuronal cells subject to oxidative insults."
22442077
reach
"Pharmacological inhibition of integrin signaling or FAK suppressed apoptosis induced by oxidation of KCNB1, as well as FAK and Src and Fyn activation."
31591393
reach
"Abstract Oxidative modification of the voltage gated potassium (K +) channel KCNB1 promotes apoptosis in the neurons of cortex and hippocampus through a signaling pathway mediated by Src tyrosine kinases."
31591393
reach
"Moreover, pharmacological inhibition of integrin signaling in primary neurons and CHO cells was protective against apoptosis induced by oxidation of KCNB1."
28383553
reach
"KCNB1 oxidation promotes inflammation, oxidative stress, neuronal apoptosis, and behavioral deficit in mouse model of traumatic brain injury a condition that, likewise AD, is associated to copious release of ROS 7."
30050035
reach
"Pharmacological inhibition of integrin signaling or FAK suppressed apoptosis induced by oxidation of KCNB1, as well as FAK and Src and Fyn activation."
28383553
reach
"When ROS levels further increase, such as in AD, oxidation of KCNB1 may become exacerbated and promote neuronal apoptosis."
27114846
reach
"XREF_BIBR, XREF_BIBR If integrins are responsible for the apoptotic stimulus, pharmacologically inhibiting integrin signaling should prevent apoptosis induced by oxidation of KCNB1, whereas inhibiting integrin signaling in cells expressing C73A should have only minor effect on their viability."
28383553
reach
"Together, these data suggest that the accumulation of KCNB1 oligomers in the membrane disrupts planar lipid raft integrity and causes apoptosis via activating the c-Src and JNK signaling pathway."
23275378
reach
"KCNB1 oxidation acts to enhance apoptosis in mammalian cell lines, whereas a KCNB1 variant resistant to oxidative modification, C73A-KCNB1, is cytoprotective."
23275378
reach
"Accordingly, cholesterol supplementation reduced apoptosis promoted by oxidation of KCNB1."
23275378
reach
"Oxidative modification of the voltage gated potassium (K +) channel KCNB1 promotes apoptosis in the neurons of cortex and hippocampus through a signaling pathway mediated by Src tyrosine kinases."
28383553
KCNB1 inhibits apoptotic process.
| 2
KCNB1 inhibits apoptotic process. 2 / 2
| 2
reach
"Inhibition of integrins prevents KCNB1 induced apoptosis."
28383553
reach
"Inhibition of FAK protects against KCNB1 mediated apoptosis."
28383553
PPP3 affects KCNB1
| 1 13
PPP3 dephosphorylates KCNB1.
| 1 12
PPP3 dephosphorylates KCNB1. 12 / 12
| 1 12
sparser
"In addition, activity-dependent Kv2.1 dephosphorylation by CaN induces a hyperpolarizing shift in the voltage-dependent activation of channels, causing a decrease in neuronal excitability ( xref )."
21273417
sparser
"For example, cytosolic Ca 2+ increase and subsequent calcineurin activation affects the gating kinetics of I DR channels via dephosphorylating Kv2.1 channels, since calcineurin-dependent dephosphorylation of Kv2.1 decreases the threshold for I DR channel opening and disrupts channel clustering, resulting in changes of activation kinetics [ xref xref ]."
28280420
sparser
"We previously found that seizures in rats in vivo , or glutamate stimulation of cultured rat hippocampal pyramidal neurons, led to calcineurin-dependent dephosphorylation of Kv2.1, and dispersion of Kv2.1 clusters. xref Initial experiments showed that glutamate stimulation of cultured neurons also led to significant hyperpolarizing shifts in voltage-dependent activation of neuronal I K . xref However, the potential impact of these changes on neuronal function could not be accurately deduced without a more comprehensive analysis of the effects of glutamate stimulation on the gating properties of neuronal Kv2.1 channels."
19276663
sparser
"Variable calcineurin-dependent dephosphorylation of Kv2.1 at 16 phosphorylated residues generates an activity gradient for channel gating and neuronal firing."
21730325
sparser
"Activity-dependent Kv2.1 dephosphorylation by calcineurin induces graded hyperpolarizing shifts in voltage-dependent activation, causing suppression of neuronal excitability."
16917065
sparser
"We previously found that reversible calcineurin-dependent Kv2.1 dephosphorylation as induced by ischemic insult is neuroprotective. xref However, sustained activation of Kv2.1, as occurs upon induction of apoptosis xref , or prolonged treatment with high levels of glutamate xref , might lead to excessive K + efflux, and subsequent induction of apoptotic or excitotoxic cell death, as we suggested previously. xref "
19276663
sparser
"In that respect, previous studies have shown that activity- and calcineurin-dependent Kv2.1 dephosphorylation induces hyperpolarizing shifts."
26890139
sparser
"This shift was blocked by WZ811 (100 nM), MK-801 (10 μM), and the calcineurin inhibitor FK506 (10 μM; xref ), suggesting that SDF-1α/CXCR4-induced elevations in [Ca 2+ ] i result in calcineurin-dependent dephosphorylation of the Kv2.1 channel protein."
23223293
sparser
"One SNP (rs756529) is intragenic within KCNB1 , which is dephosphorylated by calcineurin, a previously reported candidate gene for LV hypertrophy within this population [ xref ]."
19454037
sparser
"One SNP (rs756529) is intragenic within KCNB1 , which is dephosphorylated by calcineurin, a previously reported candidate gene for LV hypertrophy within this population."
19454037
sparser
"Our study demonstrates that SDF-1α acts upon neuronal CXCR4 to induce an NMDA receptor-dependent elevation in [Ca 2+ ] i , leading to calcineurin-dependent dephosphorylation of Kv2.1, dispersal of channel clusters and enhancement of voltage-dependent activation of Kv2.1/ I DR currents."
23223293
sparser
"During ischemia, increased intracellular zinc concentrations also induce calcineurin-dependent dephosphorylation of Kv2.1, which causes dispersal of channel clusters on the plasma membrane."
20606213
PPP3 activates KCNB1.
| 1
PPP3 activates KCNB1. 1 / 1
| 1
sparser
"The authors speculate that glutamate accumulation in the extracellular space following ischemia may activate ionotropic glutamate receptors, leading to elevated [Ca 2+ ] i , calcineurin activation, and modulation of Kv2.1 ( xref )."
20092568
SNAP receptor activity affects KCNB1
| 1 8
SNAP receptor activity binds KCNB1. 5 / 5
| 1 5
sparser
"Inhibition of Kv2.1 SNARE protein interaction interferes with dense core vesicle release from PC-12 cells, and overexpression enhances release via a mechanism independent of ion conduction ( xref )."
22648171
sparser
"Recent work demonstrating that Kv2.1 directly interacts with exocytotic SNARE proteins to modulate exocytosis xref , xref , xref raises the possibility of non-channel exocytotic function(s) of Kv2.1 in skeletal muscle regulating GLUT4 transport or function."
23431371
sparser
"Moreover, the physiological significance of the redox sensitivity of Kv2.1 in insulin secretion is unclear, because it has been reported that changes in Kv2.1 channels do not affect the levels of the critical pool of subplasma membrane calcium that regulates exocytosis. xref Because NADPH facilitates insulin exocytosis, xref it has been speculated that the binding of NADPH increases the association of Kv2.1 with SNARE proteins, which facilitates granule docking or priming. xref Although this is an interesting possibility, additional investigations are required to fully elucidate the relationship between NADP(H) and Kv2.1 and to assess its importance in regulating insulin secretion or other physiological phenomena."
23410881
sparser
"In β-cells, these Kv2.1-SNARE complex interactions can enhance insulin secretion [ xref ]."
26377690
sparser
"This suggests that the interactions of the SNARE components with Kv2.1 are abolished upon their recruitment into a full SNARE complex, which does not interact with the channel."
18636750
SNAP receptor activity binds KCNB1 and syntaxin. 2 / 2
| 2
sparser
"In particular, syntaxin associates with the C-terminus of Kv2.1 ( xref ), raising the possibility that S800 phosphorylation facilitates SNARE-mediated insertion of Kv2.1 into the plasma membrane, a hypothesis that warrants further investigation."
23223293
sparser
"Kv2.1 protein associates with syntaxin to stabilize the t-SNARE (soluble N-ethylamaleimide-sensitive factor attachment protein receptor) protein complex; 2)."
21466805
SNAP receptor activity binds KCNB1 and Plekhg5. 1 / 1
| 1
sparser
"Taken together, these findings suggest that physical interactions of both Syx and the t-SNARE complex with the C terminus of Kv2.1 are involved in channel regulation."
15525758
KCNB1 affects Integrins
| 2 6
KCNB1 binds Integrins.
| 2 2
Integrins binds KCNB1. 4 / 4
| 2 2
reach
"We next determined whether KCNB1 formed a complex with integrins in the mouse brain."
28383553
sparser
"KCNB1 forms macromolecular complexes with integrins in the mouse brain xref ."
30050035
sparser
"Here we show that the apoptotic signal originates from integrins, which form macromolecular complexes with KCNB1 channels."
31591393
reach
"To determine whether KCNB1 and integrins form complexes in the human brain, proteins were immunoprecipitated (IP) with an antibody that detects integrin alpha chain V (integrin-alpha5) and immunoblotted (IB) with an antibody that detects KCNB1 or vice versa."
30050035
KCNB1 activates Integrins.
| 4
KCNB1 activates Integrins. 4 / 4
| 4
reach
"Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain."
28383553
reach
"This leads us to conclude that the transition between the non oxidized and oxidized state of KCNB1 activates integrin signaling."
31591393
reach
"Correction : Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain."
31591393
reach
"This leads us to conclude that the transition between the non oxidized and oxidized state of KCNB1 activates integrin signaling."
28383553
SNAP25 affects KCNB1
1 1 | 5
SNAP25 binds KCNB1. 3 / 3
1 1 | 1
sparser
"In the present study, we characterize the interaction of the SNARE protein SNAP-25 (synaptosome-associated protein of 25 kDa) with the beta-cell voltage-dependent K(+) channel Kv2.1."
12403834
biogrid
No evidence text available
12403834
hprd
No evidence text available
12403834
SNAP25 binds STX1A and KCNB1. 2 / 2
| 2
sparser
"We have shown that Kv2.1 interacts with syntaxin 1A and SNAP-25 and, based on studies in oocytes, suggested a model of two distinct modes of interaction of syntaxin 1A and the complex syntaxin 1A/SNAP-25 with the C terminus of the channel."
16754785
sparser
"Expression of Kv2.1, SNAP-25, and syntaxin 1A was detected in human islet lysates by Western blot, and coimmunoprecipitation studies showed that heterologously expressed SNAP-25 and syntaxin 1A associate with Kv2.1."
12403834
SNAP25 binds KCNB1 and Plekhg5. 1 / 1
| 1
sparser
"We also demonstrated physical interactions in neuroendocrine cells between Kv2.1, Syx, and SNAP-25, characterized their effects on Kv2.1 activation and inactivation in Xenopus laevis oocytes, and suggested that they pertain to the assembly/disassembly of the Syx/SNAP-25 (t-SNARE) complex."
15525758
SNAP25 binds KCNB1 and syntaxin. 1 / 1
| 1
sparser
"Of interest, Kv2.1 binds to both syntaxin and SNAP-25 in vitro and thus has been postulated to be directly involved in membrane fusion events ( xref ; xref )."
22648171
PTPRE affects KCNB1
2 2 2 | 1
PTPRE dephosphorylates KCNB1.
1 1 | 1
PTPRE dephosphorylates KCNB1 on Y128. 2 / 2
1 1 |
hprd
No evidence text available
12615930
signor
"Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon"
10921884
PTPRE dephosphorylates KCNB1. 1 / 1
| 1
sparser
"We have previously shown that dephosphorylation of Kv2.1 by the nonreceptor-type tyrosine phosphatase PTPepsilon (cyt-PTPepsilon) down-regulates channel activity and counters its phosphorylation and up-regulation by Src or Fyn."
12615930
PTPRE binds KCNB1.
2 1 |
KCNB1 binds PTPRE. 3 / 3
2 1 |
biogrid
No evidence text available
10921884
hprd
No evidence text available
12615930
biogrid
No evidence text available
10921884
PTPRE inhibits KCNB1.
1 |
PTPRE inhibits KCNB1. 1 / 1
1 |
signor
"Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon"
10921884
KCNB1 affects SNAP25
1 1 | 5
SNAP25 binds KCNB1. 3 / 3
1 1 | 1
sparser
"In the present study, we characterize the interaction of the SNARE protein SNAP-25 (synaptosome-associated protein of 25 kDa) with the beta-cell voltage-dependent K(+) channel Kv2.1."
12403834
biogrid
No evidence text available
12403834
hprd
No evidence text available
12403834
SNAP25 binds STX1A and KCNB1. 2 / 2
| 2
sparser
"We have shown that Kv2.1 interacts with syntaxin 1A and SNAP-25 and, based on studies in oocytes, suggested a model of two distinct modes of interaction of syntaxin 1A and the complex syntaxin 1A/SNAP-25 with the C terminus of the channel."
16754785
sparser
"Expression of Kv2.1, SNAP-25, and syntaxin 1A was detected in human islet lysates by Western blot, and coimmunoprecipitation studies showed that heterologously expressed SNAP-25 and syntaxin 1A associate with Kv2.1."
12403834
SNAP25 binds KCNB1 and Plekhg5. 1 / 1
| 1
sparser
"We also demonstrated physical interactions in neuroendocrine cells between Kv2.1, Syx, and SNAP-25, characterized their effects on Kv2.1 activation and inactivation in Xenopus laevis oocytes, and suggested that they pertain to the assembly/disassembly of the Syx/SNAP-25 (t-SNARE) complex."
15525758
SNAP25 binds KCNB1 and syntaxin. 1 / 1
| 1
sparser
"Of interest, Kv2.1 binds to both syntaxin and SNAP-25 in vitro and thus has been postulated to be directly involved in membrane fusion events ( xref ; xref )."
22648171
KCNB1 affects PTK2
| 3 3
KCNB1 binds PTK2.
| 3
KCNB1 binds PTK2. 3 / 3
| 3
sparser
"Our earlier work revealed a novel mechanism underlying FAK phosphorylation/activation via formation of a FAK-Kv2.1 complex[ xref ]."
23914259
sparser
"The formation of the FAK-Kv2.1 complex increased FAK phosphorylation in neurons and Kv2.1-expressing CHO cells, which played a key role in cellular polarization and directed migration towards the wounded area in a traumatic injury model and an in vitro wound healing test[ xref ]."
23914259
sparser
"In Kv2.1-transfected CHO cells, formation of the Kv2.1-FAK complex was stimulated by fibronectin/integrin and inhibited by the K(+) channel blocker tetraethylammonium (TEA)."
18615577
KCNB1 activates PTK2.
| 3
KCNB1 activates PTK2. 3 / 3
| 3
reach
"Pharmacological inhibition of integrin signaling or FAK suppressed apoptosis induced by oxidation of KCNB1, as well as FAK and Src and Fyn activation."
28383553
reach
"To determine whether oxidation of KCNB1 could induce activation of FAK via integrin signaling, we assessed the fraction of autophosphorylated FAK at tyr397 in CHO cells transfected with WT or C73A."
28383553
reach
"Pharmacological inhibition of integrin signaling or FAK suppressed apoptosis induced by oxidation of KCNB1, as well as FAK and Src and Fyn activation."
31591393
Pyraclofos affects KCNB1
| 4 1
Pyraclofos activates KCNB1.
| 4
Pyraclofos activates KCNB1. 4 / 4
| 4
sparser
"Voltage-activated Kv2.1 channels have properties commensurate with a contribution to delayed rectifier currents and are expressed in neurones throughout the mammalian central nervous system."
14608003
sparser
"We find that voltage activation of Kv2.1 channels triggers GxTX dissociation, and thus GxTX binding dynamically marks Kv2 activation."
25331865
sparser
"Furthermore, it was reported that coexpression of stx1A reduced the surface expression of the voltage-activated potassium channel Kv2.1 ( xref ) but increased the surface expression of Kv1.1 ( xref )."
24743596
sparser
"The voltage-activated K(+) channel subunit Kv2.1 can form heterotetramers with members of the Kv6 subfamily, generating channels with biophysical properties different from homomeric Kv2.1 channels."
19074135
Pyraclofos inhibits KCNB1.
| 1
Pyraclofos inhibits KCNB1. 1 / 1
| 1
reach
"Furthermore, external Ba2+ also caused a very low affinity (Kd approximately 30 mM) and voltage independent block of the open DRK1 channel."
8341271
Hsa-miR-8485 affects KCNB1
5 |
Transcriptionally active hsa-miR-8485 decreases the amount of KCNB1. 5 / 5
5 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
23824327
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-603 affects KCNB1
5 |
Transcriptionally active hsa-miR-603 decreases the amount of KCNB1. 5 / 5
5 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
23824327
VAMP2 affects KCNB1
| 5
VAMP2 binds KCNB1. 5 / 5
| 5
sparser
"It should be noted that in a different set of experiments, some VAMP2 binding to Kv2.1 C1a peptide was observed; its intensity was always significantly lower than that of syntaxin (not shown)."
18167541
sparser
"Recently, we showed that also VAMP2, the vesicular SNARE, interacts physically and functionally with Kv2.1."
18636750
sparser
"We report here that Kv2.1 interacts with VAMP2, the vesicular SNARE partner that is also present at high concentration in neuronal plasma membrane."
18542995
sparser
"Using the interaction of VAMP2 with Kv2.1 in Xenopus oocytes as a probe, we showed that coexpression of the t-SNARE complex with VAMP2 abolished the VAMP2 effect on channel inactivation and reduced the amount of VAMP2 that coprecipitated with Kv2.1."
18636750
sparser
"Given the proposed role for surface VAMP2 in the regulation of the vesicle cycle and the important role for the sustained Kv2.1 current in the regulation of dendritic calcium entry during high-frequency stimulation, the interaction of VAMP2 with Kv2.1 N terminus may contribute, alongside with the interaction of syntaxin with Kv2.1 C terminus, to the activity dependence of DCV release."
18542995
KCNE5 affects KCNB1
1 | 4 4
KCNE5 inhibits KCNB1.
| 2
KCNE5 inhibits KCNB1. 2 / 2
| 2
reach
"Kv2.1 (KCNB1), which is a delayed rectifier alpha subunit (Frech et al., 1989) expressed widely including in mouse and rat heart (Dixon and McKinnon, 1994; Bou-Abboud et al., 2000), was inhibited 90% by KCNE4, and 50% by KCNE5, with no obvious change in gating kinetics for the remaining current (David et al., 2015)."
27484720
reach
"Kv2.1 (KCNB1), which is a delayed rectifier alpha subunit 68 expressed widely including in mouse and rat heart XREF_BIBR, XREF_BIBR, was inhibited 90% by KCNE4, and 50% by KCNE5, with no obvious change in gating kinetics for the remaining current 71."
27484720
KCNE5 activates KCNB1.
| 2
KCNE5 activates KCNB1. 2 / 2
| 2
reach
"In the brain, the ability of KCNE5 to modulate Kv2.1 and several KCNQ isoforms suggests possible leads for its potential roles in the CNS, but these have not been investigated in vivo to my knowledge."
27484720
reach
"In the brain, the ability of KCNE5 to modulate Kv2.1 and several KCNQ isoforms suggests possible leads for its potential roles in the CNS, but these have not been investigated in vivo to my knowledge.KCNE5 coding region sequence variants have been suggested to associate with atrial fibrillation and Brugada syndrome, but not LQTS thus far (Ohno et al., 2011; Ravn et al., 2005; Ravn et al., 2008)."
27484720
KCNE5 binds KCNB1.
1 | 4
KCNB1 binds KCNE5. 1 / 1
1 | 4
biogrid
No evidence text available
26242757
KCNB1 affects VAMP2
| 5
VAMP2 binds KCNB1. 5 / 5
| 5
sparser
"It should be noted that in a different set of experiments, some VAMP2 binding to Kv2.1 C1a peptide was observed; its intensity was always significantly lower than that of syntaxin (not shown)."
18167541
sparser
"Recently, we showed that also VAMP2, the vesicular SNARE, interacts physically and functionally with Kv2.1."
18636750
sparser
"We report here that Kv2.1 interacts with VAMP2, the vesicular SNARE partner that is also present at high concentration in neuronal plasma membrane."
18542995
sparser
"Using the interaction of VAMP2 with Kv2.1 in Xenopus oocytes as a probe, we showed that coexpression of the t-SNARE complex with VAMP2 abolished the VAMP2 effect on channel inactivation and reduced the amount of VAMP2 that coprecipitated with Kv2.1."
18636750
sparser
"Given the proposed role for surface VAMP2 in the regulation of the vesicle cycle and the important role for the sustained Kv2.1 current in the regulation of dendritic calcium entry during high-frequency stimulation, the interaction of VAMP2 with Kv2.1 N terminus may contribute, alongside with the interaction of syntaxin with Kv2.1 C terminus, to the activity dependence of DCV release."
18542995
KCNB1 affects SRC
1 1 | 1 2
KCNB1 binds SRC.
1 1 | 1
SRC binds KCNB1. 2 / 2
1 1 |
biogrid
No evidence text available
12615930
hprd
No evidence text available
12615930
P38 binds SRC and KCNB1. 1 / 1
| 1
sparser
"In previous studies [ xref , xref ], we reported that the phosphorylation of Kv2.1 by Src and p38 kinases is associated with oxidant-triggered apoptotic K + current surges in transfected CHO cells."
26115091
KCNB1 activates SRC.
| 2
KCNB1 activates SRC. 2 / 2
| 2
reach
"Pharmacological inhibition of integrin signaling or FAK suppressed apoptosis induced by oxidation of KCNB1, as well as FAK and Src and Fyn activation."
28383553
reach
"Pharmacological inhibition of integrin signaling or FAK suppressed apoptosis induced by oxidation of KCNB1, as well as FAK and Src and Fyn activation."
31591393
KCNB1 affects INS
| 2 3
KCNB1 inhibits INS.
| 3
KCNB1 inhibits INS. 3 / 3
| 3
reach
"In our previous study, we had assessed in the Chinese Han population the association of KCNB1 rs1051295 with metabolic traits indicating metabolic syndrome, and showed that KCNB1 rs1051295 genotype TT was associated with increase of waist to hip ratio (WHR), fasting insulin (FINS), triglycerides (TG) and decreased insulin sensitivity at basal condition."
26377690
reach
"For example, glucose induced the de-phosphorylation of Ca 2+ -dependent protein phosphatase calcineurin target site on voltage gated potassium channel Kv2.1 (Kcnb1), which would activate this K + channel and increase outward K + currents thus impaired insulin exocytosis 31."
28432305
reach
"Although we had already found that KCNB1 rs1051295 genotype TT was associated with T2D and decreased insulin sensitivity in our previous study, no association was observed for rs1051295 and insulin resistance in either dominant model (P = 0.72, OR = 1.07 (0.75,1.51)) or recessive model (P = 0.24, OR = 0.75 (0.47,1.20)) by univariate or multivariate analysis in this study."
26377690
KCNB1 binds INS.
| 2
INS binds KCNB1. 2 / 2
| 2
sparser
"In summary, we unexpectedly found that KCNB1 rs1051295 genotype TT was associated with decreased insulin sensitivity at basal conditions in a general population."
23431371
sparser
"Together, these results indicate that KCNB1 is likely associated with changes in lipid metabolism and insulin sensitivity."
26377690
Hsa-miR-5695 affects KCNB1
4 |
Transcriptionally active hsa-miR-5695 decreases the amount of KCNB1. 4 / 4
4 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
23824327
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-3145-5p affects KCNB1
4 |
Transcriptionally active hsa-miR-3145-5p decreases the amount of KCNB1. 4 / 4
4 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
23824327
biopax:mirtarbase
No evidence text available
27418678
Glutamate(2-) affects KCNB1
| 4
Glutamate(2-) dephosphorylates KCNB1. 4 / 4
| 4
sparser
"Because the glutamine-glutamate cycle is also directly linked to the citric acid cycle ( xref ), the cessation of the cycle would also affect the glutamate uptake of astrocytes ( xref ; xref ) which is also implicated in our results that MSO induced the glutamate-dependent Kv2.1 dephosphorylation."
18716211
sparser
"Our finding shows that inhibiting GLT-1 function with DHK and TBOA is sufficient to cause glutamate-dependent Kv2.1 dephosphorylation in vitro, although this does not exclude the possibility of glutamate release from astrocytes during ischemia ( xref ; xref ; xref ; xref ; xref )."
18716211
sparser
"Glutamate produces a Ca 2+ -dependent dephosphorylation of Kv2.1 channels, which disrupts channel clusters and increases mean open channel probability and conductance (Murakoshi et al. xref ; Misonou et al. xref )."
20396973
sparser
"Taken together with the preliminary finding of another group that a non-selective inhibitor of glutamate transporter, TBOA ( xref ), induces Kv2.1 dephosphorylation in organotypic hippocampal slice culture ( xref ), we hypothesized that the dysfunction of glutamate transporters in astrocytes during ischemia results in the accumulation of extracellular glutamate and glutamate-induced Kv2.1 modulation."
18716211
Flotillin-1 affects KCNB1
| 4
KCNB1 binds flotillin-1. 4 / 4
| 4
sparser
"Furthermore, co-IP experiments showed that a direct interaction between Kv2.1 and flotillin-1 could be detected (Fig.  xref F)."
27221754
sparser
"In order to further characterize the interactions between flotillin-1 and Kv2.1, we employed the minimally invasive BiFC technique to directly visualize the protein complex formation in live HEK-293 cells (Fig.  xref A)."
27221754
sparser
"Thus, we believe that flotillin-1 and Kv2.1 form a complex on the lipid rafts regions of the cell membrane in vivo ."
27221754
sparser
"We therefore studied the flotillin-1 and Kv2.1 interactions following similar protocol."
27221754
KCNB1 affects autophagy
| 4
KCNB1 activates autophagy.
| 3
KCNB1 activates autophagy. 3 / 3
| 3
reach
"To determine the roles of these kinases in KCNB1 induced autophagy, we evaluated the phosphorylation status of these MAPK proteins in U87MG and U118MG cells."
28144039
reach
"Western blot analysis showed that the protein levels of LC3II in xenografts from the U87MG-KCNB1+ group were much higher than those from the U87MG-CTR group, confirming that KCNB1 overexpression induced autophagy in vivo."
28144039
reach
"In vivo studies showed that KCNB1 induced autophagy while inhibiting tumor growth and increasing survival."
28144039
KCNB1 inhibits autophagy.
| 1
KCNB1 inhibits autophagy. 1 / 1
| 1
reach
"KEGG pathway analysis and in vitro studies suggested that the ERK pathway is involved in KCNB1 mediated regulation of autophagy, which was confirmed by inhibition of KCNB1 induced autophagy by using a selective ERK1/2 inhibitor (U0126) or siERK1/2."
28144039
KCNB1 affects FYN
| 1 3
KCNB1 activates FYN.
| 3
KCNB1 activates FYN. 3 / 3
| 3
reach
"Pharmacological inhibition of integrin signaling or FAK suppressed apoptosis induced by oxidation of KCNB1, as well as FAK and Src and Fyn activation."
31591393
reach
"Pharmacological inhibition of integrin signaling or FAK suppressed apoptosis induced by oxidation of KCNB1, as well as FAK and Src and Fyn activation."
28383553
reach
"Together these data led us to conclude that KCNB1 oligomers activate an integrin-FAK-Src and Fyn apoptotic pathway that is conserved in both primary hippocampal neurons and mammalian cells."
28383553
KCNB1 binds FYN.
| 1
FYN binds KCNA5 and KCNB1. 1 / 1
| 1
sparser
"The Kv1.5 and Kv2.1 K+-channel alpha subunits are constitutively tyrosine phosphorylated and physically associate with Fyn both in cultured SCs and in the sciatic nerve in vivo."
9707431
KCNB1 affects EAF2
| 3 1
EAF2 binds KCNB1. 4 / 4
| 3 1
sparser
"In our previous study, we had assessed in the Chinese Han population the association of KCNB1 rs1051295 with metabolic traits indicating metabolic syndrome, and showed that KCNB1 rs1051295 genotype TT was associated with increase of waist to hip ratio (WHR), fasting insulin (FINS), triglycerides (TG) and decreased insulin sensitivity at basal condition."
26377690
reach
"KCNB1 rs1051295 Associated with T2D related Traits Under Basal Condition and OGTT."
23431371
sparser
"These results indicate that KCNB1 is likely associated with metabolic traits that may either predispose or protect from progression to metabolic syndrome."
26377690
sparser
"KCNB1 rs1051295 Associated with T2D-related Traits Under Basal Condition and OGTT."
23431371
Ischemia affects KCNB1
| 4
Ischemia dephosphorylates KCNB1. 4 / 4
| 4
sparser
"In cultured rat hippocampal neurons, chemical ischemia (CI) elicited a similar dephosphorylation and translocation of Kv2.1."
16319318
sparser
"The released Ca 2+ also contributes to the ischemia-induced Kv2.1 dephosphorylation, but only when the ischemic stress is prolonged."
18716211
sparser
"Next, we examined whether Zn 2+ was required for the ischemia-induced dephosphorylation of Kv2.1 channel subunits."
20092568
sparser
"To determine whether sub-lethal ischemia could dephosphorylate Kv2.1, we performed immunoblot experiments on cortical neurons exposed to either KCN or control conditions ( xref )."
20092568
Integrins affects KCNB1
| 2 2
Integrins binds KCNB1. 4 / 4
| 2 2
reach
"We next determined whether KCNB1 formed a complex with integrins in the mouse brain."
28383553
sparser
"KCNB1 forms macromolecular complexes with integrins in the mouse brain xref ."
30050035
sparser
"Here we show that the apoptotic signal originates from integrins, which form macromolecular complexes with KCNB1 channels."
31591393
reach
"To determine whether KCNB1 and integrins form complexes in the human brain, proteins were immunoprecipitated (IP) with an antibody that detects integrin alpha chain V (integrin-alpha5) and immunoblotted (IB) with an antibody that detects KCNB1 or vice versa."
30050035
IK affects KCNB1
| 4
IK binds KCNB1.
| 3
IK binds KCNB1. 1 / 1
| 1
sparser
"As expected, bath application of NMDA to hippocampal cultures reduced the size of Kv2.1 clusters and produced a hyperpolarizing shift in the voltage-dependent activation of I K that was associated with dephosphorylated Kv2.1 channels."
19185209
P38 binds IK and KCNB1. 1 / 1
| 1
sparser
"Taken together, these results suggest that gp120 induces hippocampal neuron apoptosis by enhancement of the Ik, which might be associated with increased Kv2.1 expression via the p38 MAPK pathway."
26393286
IK binds KCNA2 and KCNB1. 1 / 1
| 1
sparser
"Kv1.2 and Kv2.1 were associated with IK(DR); Slo and KCNN4 were associated with IK(Ca); and Kv1.4 and Kv4.3 were associated with Ito."
18505444
IK inhibits KCNB1.
| 1
IK inhibits KCNB1. 1 / 1
| 1
sparser
"In contrast, Kv2.1(S5–S6⋯Kv1.2) I K inhibition by anoxia was observed over the whole range of potentials similar to wild-type Kv1.2 current."
12804584
HaTx affects KCNB1
| 4
HaTx inhibits KCNB1. 4 / 4
| 4
reach
"Thus, HaTx inhibits the drk1 K+ channel, not by physically occluding the ion conduction pore, but by modifying channel gating."
9136774
reach
"Since HaTx inhibits DRK1 by hindering the movement of gating charges, the HaTx sensitivity of the chimera indicates that its gate remains under control of the voltage sensors."
12407078
reach
"To test further if the substituting KcsA pore is indeed under the control of the voltage sensors, we made a chimera between KcsA and the DRK1 (K V 2.1) voltage gated K + channel, because DRK1 is inhibited by HaTx."
12407078
reach
"We studied the mechanism by which Hanatoxin (HaTx) inhibits the drk1 voltage gated K+ channel."
9136774
EAF2 affects KCNB1
| 3 1
EAF2 binds KCNB1. 4 / 4
| 3 1
sparser
"In our previous study, we had assessed in the Chinese Han population the association of KCNB1 rs1051295 with metabolic traits indicating metabolic syndrome, and showed that KCNB1 rs1051295 genotype TT was associated with increase of waist to hip ratio (WHR), fasting insulin (FINS), triglycerides (TG) and decreased insulin sensitivity at basal condition."
26377690
reach
"KCNB1 rs1051295 Associated with T2D related Traits Under Basal Condition and OGTT."
23431371
sparser
"These results indicate that KCNB1 is likely associated with metabolic traits that may either predispose or protect from progression to metabolic syndrome."
26377690
sparser
"KCNB1 rs1051295 Associated with T2D-related Traits Under Basal Condition and OGTT."
23431371
AMPK affects KCNB1
| 4
AMPK phosphorylates KCNB1.
| 3
AMPK phosphorylates KCNB1. 3 / 3
| 3
sparser
"We identified two sites (S440 and S537) directly phosphorylated on Kv2.1 by AMPK and, using phosphospecific antibodies and quantitative mass spectrometry, show that phosphorylation of both sites increased in A-769662-treated cells."
22006306
sparser
"Since we have shown that AMPK activation was significantly impaired by HCV infection ( xref ), it will be of great interest to see how Kv2.1 phosphorylation by AMPK is affected during either HCV infection or NS5A expression."
23857585
sparser
"AMPK phosphorylates purified Kv2.1 at two sites in its cytoplasmic C-terminal tail, and the effect of AMPK activation on voltage gating was lost in cells in which one of these (Ser440) was substituted with a non-phosphorylatable alanine xref ."
22436748
AMPK activates KCNB1.
| 1
AMPK activates KCNB1. 1 / 1
| 1
sparser
"In accordance with an AMPK-induced activation of Kv2.1, introduction of active AMPK into cultured hippocampal neurons caused a decrease in the frequency of evoked action potentials."
23181165
Toxin affects KCNB1
| 2 1
Toxin inhibits KCNB1. 2 / 2
| 2
sparser
"The sequence of GxTX-1E is similar to toxins known to interact with voltage sensors ( xref ) and electrophysiological studies show that the toxin inhibits Kv2.1 by modifying gating ( xref , xref ) and that mutations in the S3b-S4 paddle region of the voltage-sensing domain of Kv2.1 weaken toxin affinity ( xref )."
20509680
sparser
"This toxin does not inhibit Kv2.1 (in Xenopus oocytes), and yet it does inhibit the paddle chimera, which contains the Kv2.1 voltage sensor paddle xref ."
18638484
Toxin inhibits KCNB1. 1 / 1
| 1
reach
"The toxin inhibits DRK1 by binding to its S3-S4 linker and thereby hindering the movement of its gating charges."
12407078
RBPJ affects KCNB1
| 3
RBPJ binds KCNB1. 1 / 1
| 1
sparser
"Interestingly, we observe dynamic binding of RBP-J to the Kcnip2 promoter in heart failure similar to what we observe in adult Notch-activated mice, while dynamic RBP-J binding to the Kcnb1 promoter was not detected in heart failure ( xref )."
27697822
KCNIP2 binds RBPJ and KCNB1. 1 / 1
| 1
sparser
"Notch activation resulted in over 3.5 fold enrichment of RBP-J binding at both the Kcnip2 ( P = 0.003) and Kcnb1 ( P = 0.001 ) promoters ( xref ), consistent with a Notch-regulated dynamic binding profile."
27697822
KCNIP2 binds RBPJ, KCNB1, and NOTCH1. 1 / 1
| 1
sparser
"In contrast to the dynamic RBP-J binding to Kcnip2 and Kcnb1 promoters in the presence of NICD ( xref ), we did not detect an increase in RBP-J binding to the Hrt2 promoter and enhancer sites in LV nor RV in the presence of NICD ( xref )."
27697822
PTK2 affects KCNB1
| 3
KCNB1 binds PTK2. 3 / 3
| 3
sparser
"Our earlier work revealed a novel mechanism underlying FAK phosphorylation/activation via formation of a FAK-Kv2.1 complex[ xref ]."
23914259
sparser
"The formation of the FAK-Kv2.1 complex increased FAK phosphorylation in neurons and Kv2.1-expressing CHO cells, which played a key role in cellular polarization and directed migration towards the wounded area in a traumatic injury model and an in vitro wound healing test[ xref ]."
23914259
sparser
"In Kv2.1-transfected CHO cells, formation of the Kv2.1-FAK complex was stimulated by fibronectin/integrin and inhibited by the K(+) channel blocker tetraethylammonium (TEA)."
18615577
MAPK affects KCNB1
| 3
MAPK binds KCNB1.
| 2
MAPK binds KCNB1. 2 / 2
| 2
sparser
"KEGG pathway analysis showed that KCNB1 was associated with the MAPK signaling pathway (Fig.  xref )."
28144039
sparser
"Many stimuli cause apoptosis also trigger autophagy and KEGG pathways analysis showed that KCNB1 was associated with MAPK signaling pathway, which can control the balance of apoptosis and autophagy xref , xref ."
28144039
MAPK phosphorylates KCNB1.
| 1
MAPK phosphorylates KCNB1. 1 / 1
| 1
sparser
"xref suggested that NS5A blocked hepatocyte K + current function by interfering with p38 kinase activation and subsequent phosphorylation of Kv2.1 by this MAPK."
22745487
KCNB1 affects RBPJ
| 3
RBPJ binds KCNB1. 1 / 1
| 1
sparser
"Interestingly, we observe dynamic binding of RBP-J to the Kcnip2 promoter in heart failure similar to what we observe in adult Notch-activated mice, while dynamic RBP-J binding to the Kcnb1 promoter was not detected in heart failure ( xref )."
27697822
KCNIP2 binds RBPJ and KCNB1. 1 / 1
| 1
sparser
"Notch activation resulted in over 3.5 fold enrichment of RBP-J binding at both the Kcnip2 ( P = 0.003) and Kcnb1 ( P = 0.001 ) promoters ( xref ), consistent with a Notch-regulated dynamic binding profile."
27697822
KCNIP2 binds RBPJ, KCNB1, and NOTCH1. 1 / 1
| 1
sparser
"In contrast to the dynamic RBP-J binding to Kcnip2 and Kcnb1 promoters in the presence of NICD ( xref ), we did not detect an increase in RBP-J binding to the Hrt2 promoter and enhancer sites in LV nor RV in the presence of NICD ( xref )."
27697822
KCNB1 affects PTPRE
2 1 |
KCNB1 binds PTPRE. 3 / 3
2 1 |
biogrid
No evidence text available
10921884
hprd
No evidence text available
12615930
biogrid
No evidence text available
10921884
KCNB1 affects MAPK
| 2 1
KCNB1 binds MAPK.
| 2
MAPK binds KCNB1. 2 / 2
| 2
sparser
"KEGG pathway analysis showed that KCNB1 was associated with the MAPK signaling pathway (Fig.  xref )."
28144039
sparser
"Many stimuli cause apoptosis also trigger autophagy and KEGG pathways analysis showed that KCNB1 was associated with MAPK signaling pathway, which can control the balance of apoptosis and autophagy xref , xref ."
28144039
KCNB1 activates MAPK.
| 1
KCNB1 activates MAPK. 1 / 1
| 1
reach
"DRK1 is located in an upstream position in the HOG pathway, whose RR senses and relays environmental signals and subsequently activates the MAPK pathway; this location may explain decrease in Ste20 resulting from interference of DRK1."
29115539
KCNB1 affects IK
| 3
IK binds KCNB1. 1 / 1
| 1
sparser
"As expected, bath application of NMDA to hippocampal cultures reduced the size of Kv2.1 clusters and produced a hyperpolarizing shift in the voltage-dependent activation of I K that was associated with dephosphorylated Kv2.1 channels."
19185209
P38 binds IK and KCNB1. 1 / 1
| 1
sparser
"Taken together, these results suggest that gp120 induces hippocampal neuron apoptosis by enhancement of the Ik, which might be associated with increased Kv2.1 expression via the p38 MAPK pathway."
26393286
IK binds KCNA2 and KCNB1. 1 / 1
| 1
sparser
"Kv1.2 and Kv2.1 were associated with IK(DR); Slo and KCNN4 were associated with IK(Ca); and Kv1.4 and Kv4.3 were associated with Ito."
18505444
INS affects KCNB1
1 | 2
INS binds KCNB1.
| 2
INS binds KCNB1. 2 / 2
| 2
sparser
"In summary, we unexpectedly found that KCNB1 rs1051295 genotype TT was associated with decreased insulin sensitivity at basal conditions in a general population."
23431371
sparser
"Together, these results indicate that KCNB1 is likely associated with changes in lipid metabolism and insulin sensitivity."
26377690
INS increases the amount of KCNB1.
1 |
Transcriptionally active INS increases the amount of KCNB1. 1 / 1
1 |
biopax:ctd
No evidence text available
28628672
Smo-1 affects KCNB1
| 2
KCNB1 binds smo-1. 2 / 2
| 2
sparser
"To confirm that endogenous Kv2.1 and SUMO associate in hippocampal neurons, we used antibody-mediated FRET ( xref )."
21518833
sparser
"Association of native Kv2.1 with SUMO at the neuronal cell surface."
21518833
Ion channel affects KCNB1
| 2
KCNB1 binds ion channel. 2 / 2
| 2
sparser
"The presence of potential 3 10 -helical character in the PrRP20 models may be a result of its amphipathic nature and the fact that the NMR data were also collected in SDS micelles at high PrRP20 concentration (0.5−15 mM). xref Indeed, there is evidence that amphipathic helices can assume extended (often 3 10 ) helical conformations in certain mediums, such as in detergent micelles. xref , xref Remarkably, it has been proposed that the R 1 xxR 2 xxR 3 xxR 4 xxR 5 xxR 6 motif in the Kv1.2- and Kv2.1-chimeric potassium ion channel structures form an extended 3 10 -helix, which allows the arginine residues to sit on the same side of the helix. xref , xref This is also often observed in our models of PrRP, which contains three arginine residues in an R 1 xxR 2 xxxR 3 motif."
23426574
sparser
"Direct action could result from interaction of the sigma receptor with the Kv2.1 or other ion channels."
20167253
Hsa-miR-3941 affects KCNB1
2 |
Transcriptionally active hsa-miR-3941 decreases the amount of KCNB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-362-3p affects KCNB1
2 |
Transcriptionally active hsa-miR-362-3p decreases the amount of KCNB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-329-3p affects KCNB1
2 |
Transcriptionally active hsa-miR-329-3p decreases the amount of KCNB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
23313552
Cephradine affects KCNB1
| 2
Cephradine dephosphorylates KCNB1. 2 / 2
| 2
sparser
"As shown in xref , the glutamate receptor antagonists completely blocked the Kv2.1 dephosphorylation induced by 10 min CED."
18716211
sparser
"To test whether there is an accumulation of glutamate during CED, we examined the effect of glutamate receptor antagonists on the CED-induced Kv2.1 dephosphorylation."
18716211
YRDC affects KCNB1
| 2
YRDC dephosphorylates KCNB1. 2 / 2
| 2
sparser
"Ischemia induced dephosphorylation of Kv2.1 in the neuroglial interaction."
18716211
sparser
"Ischemia induces rapid Kv2.1 dephosphorylation and a dispersal of these clusters, accompanied by a hyperpolarizing shift in their voltage-dependent activation kinetics."
20092568
Voltage_gated_ion_channels affects KCNB1
| 2
Voltage_gated_ion_channels activates KCNB1. 2 / 2
| 2
sparser
"Additionally, these results suggest that constitutively active CK2 by itself may downregulate Kv2.1 activity under basal conditions, or that the CK2 inhibitor may have induce a shift in the voltage-gated activation of Kv2.1."
26472706
sparser
"However, we found Kv2.1 channel voltage-gated activation to be the same in vehicle-treated and IQA-treated neurons."
26472706
TEA affects KCNB1
| 1 1
TEA binds KCNB1.
| 1
KCNB1 binds TEA. 1 / 1
| 1
sparser
"[K + ] Dependence of the Interaction of Internal TEA with Wild-Type Kv2.1."
10352033
TEA activates KCNB1.
| 1
TEA activates KCNB1. 1 / 1
| 1
reach
"As predicted from block of whole-oocyte currents, internal TEA produced a slow block of DRK1 and RCK2 single-channel currents but had almost no effect on r-NGK2 single-channel currents."
1875913
SLC6A3 affects KCNB1
| 2
SLC6A3 binds KCNB1. 2 / 2
| 2
sparser
"Given recent reports of Kv2.1 dysregulation in neurological disorders, it is possible that alterations in the functional interaction between DAT and Kv2.1 affect dopamine neuron activity."
30824538
sparser
"Here, we describe a novel physical and functional interaction between DAT and the voltage-gated K+ channel Kv2.1 (potassium voltage-gated channel subfamily B member 1 or KCNB1)."
30824538
SLC1A2 affects KCNB1
| 2
SLC1A2 dephosphorylates KCNB1. 2 / 2
| 2
sparser
"Thus, we next investigated whether ethanol prevented NMDA- and EAAT2-induced dephosphorylation of Kv2.1 in organotypic hippocampal slices that, unlike dispersed cell cultures, maintain a normal glial-neuronal component ( xref ; xref ; xref )."
19185209
sparser
"Given that ethanol is capable of inhibiting NMDA receptor and EAAT2 dephosphorylation of Kv2.1, it is tempting to speculate that tonic NMDA currents that arise from astrocytic glutamate release are blocked during acute exposure to ethanol."
19185209
RyR affects KCNB1
| 2
KCNB1 binds RyR. 2 / 2
| 2
sparser
"This suggests that Kv2.1 and RyR form clusters independent of one another."
24962901
sparser
"Future studies will determine whether specific protein kinases and phosphatases associate with these unique Kv2.1:RyR assemblies in MSNs, and their role on regulating Kv2.1 in response to stimulation by dopaminergic, muscarinic and other modulatory signaling pathways crucial to regulating the physiology of MSNs."
24962901
PTPRA affects KCNB1
2 |
PTPRA inhibits KCNB1.
1 |
PTPRA inhibits KCNB1. 1 / 1
1 |
signor
"Ptpalpha inhibits kv channels more strongly than ptpepsilon;this correlates with constitutive association of ptpalpha with kv2.1, driven by membranal localization of ptpalpha."
16870705
PTPRA dephosphorylates KCNB1.
1 |
PTPRA dephosphorylates KCNB1. 1 / 1
1 |
signor
"Ptpalpha inhibits kv channels more strongly than ptpepsilon;this correlates with constitutive association of ptpalpha with kv2.1, driven by membranal localization of ptpalpha."
16870705
NOG affects KCNB1
2 |
Transcriptionally active NOG decreases the amount of KCNB1. 2 / 2
2 |
biopax:ctd
No evidence text available
27188386
biopax:ctd
No evidence text available
27188386
NMDAR affects KCNB1
| 2
NMDAR dephosphorylates KCNB1.
| 1
NMDAR dephosphorylates KCNB1. 1 / 1
| 1
sparser
"Kv2.1 channels are phosphorylated at multiple sites ( xref ), and these data suggest that extrasynaptic NMDA receptors may dephosphorylate Kv2.1 channels at calcineurin-independent dephosphorylation sites."
18753382
NMDAR binds KCNB1.
| 1
KCNB1 binds NMDAR. 1 / 1
| 1
sparser
"Surprisingly, hyperactivation of synaptic NMDA receptors was not associated with changes in Kv2.1 dephosphorylation ( xref ), voltage-dependency for activation of I K ( xref ), cell capacitance, current density, or membrane-associated Kv2.1 protein levels ( xref )."
18753382
NEDD4L affects KCNB1
2 |
KCNB1 binds NEDD4L. 2 / 2
2 |
biogrid
No evidence text available
19953087
biogrid
No evidence text available
19953087
MAP3K11 affects KCNB1
| 2 2
MAP3K11 activates KCNB1. 2 / 2
| 2 2
sparser
"MLK3 Activation of Kv2.1 Is Inhibited by NS5A."
23857585
sparser
"In this study, we further demonstrate that MLK3 activates Kv2.1 and induces cellular apoptosis, processes suppressed by HCV NS5A in a P2-dependent manner."
23857585
KCNB1 affects smo-1
| 2
KCNB1 binds smo-1. 2 / 2
| 2
sparser
"To confirm that endogenous Kv2.1 and SUMO associate in hippocampal neurons, we used antibody-mediated FRET ( xref )."
21518833
sparser
"Association of native Kv2.1 with SUMO at the neuronal cell surface."
21518833
KCNB1 affects ion channel
| 2
KCNB1 binds ion channel. 2 / 2
| 2
sparser
"The presence of potential 3 10 -helical character in the PrRP20 models may be a result of its amphipathic nature and the fact that the NMR data were also collected in SDS micelles at high PrRP20 concentration (0.5−15 mM). xref Indeed, there is evidence that amphipathic helices can assume extended (often 3 10 ) helical conformations in certain mediums, such as in detergent micelles. xref , xref Remarkably, it has been proposed that the R 1 xxR 2 xxR 3 xxR 4 xxR 5 xxR 6 motif in the Kv1.2- and Kv2.1-chimeric potassium ion channel structures form an extended 3 10 -helix, which allows the arginine residues to sit on the same side of the helix. xref , xref This is also often observed in our models of PrRP, which contains three arginine residues in an R 1 xxR 2 xxxR 3 motif."
23426574
sparser
"Direct action could result from interaction of the sigma receptor with the Kv2.1 or other ion channels."
20167253
KCNB1 affects exocytosis
| 2
KCNB1 inhibits exocytosis.
| 1
KCNB1 inhibits exocytosis. 1 / 1
| 1
reach
"For example, glucose induced the de-phosphorylation of Ca 2+ -dependent protein phosphatase calcineurin target site on voltage gated potassium channel Kv2.1 (Kcnb1), which would activate this K + channel and increase outward K + currents thus impaired insulin exocytosis 31."
28432305
KCNB1 activates exocytosis.
| 1
KCNB1 activates exocytosis. 1 / 1
| 1
reach
"However, knockdown of KCNB1, but not KCNB2, impairs depolarization induced exocytosis in human beta-cells (XREF_FIG), which is consistent with the divergent C-terminal homology and an inability of Kv2.2 to bind the syntaxin 1A/SNAP -25 complex."
28607108
KCNB1 affects SNAP25, and STX1A
| 2
SNAP25 binds STX1A and KCNB1. 2 / 2
| 2
sparser
"We have shown that Kv2.1 interacts with syntaxin 1A and SNAP-25 and, based on studies in oocytes, suggested a model of two distinct modes of interaction of syntaxin 1A and the complex syntaxin 1A/SNAP-25 with the C terminus of the channel."
16754785
sparser
"Expression of Kv2.1, SNAP-25, and syntaxin 1A was detected in human islet lysates by Western blot, and coimmunoprecipitation studies showed that heterologously expressed SNAP-25 and syntaxin 1A associate with Kv2.1."
12403834
KCNB1 affects SNAP receptor activity, and syntaxin
| 2
SNAP receptor activity binds KCNB1 and syntaxin. 2 / 2
| 2
sparser
"In particular, syntaxin associates with the C-terminus of Kv2.1 ( xref ), raising the possibility that S800 phosphorylation facilitates SNARE-mediated insertion of Kv2.1 into the plasma membrane, a hypothesis that warrants further investigation."
23223293
sparser
"Kv2.1 protein associates with syntaxin to stabilize the t-SNARE (soluble N-ethylamaleimide-sensitive factor attachment protein receptor) protein complex; 2)."
21466805
KCNB1 affects SLC6A3
| 2
SLC6A3 binds KCNB1. 2 / 2
| 2
sparser
"Given recent reports of Kv2.1 dysregulation in neurological disorders, it is possible that alterations in the functional interaction between DAT and Kv2.1 affect dopamine neuron activity."
30824538
sparser
"Here, we describe a novel physical and functional interaction between DAT and the voltage-gated K+ channel Kv2.1 (potassium voltage-gated channel subfamily B member 1 or KCNB1)."
30824538
KCNB1 affects RyR
| 2
KCNB1 binds RyR. 2 / 2
| 2
sparser
"This suggests that Kv2.1 and RyR form clusters independent of one another."
24962901
sparser
"Future studies will determine whether specific protein kinases and phosphatases associate with these unique Kv2.1:RyR assemblies in MSNs, and their role on regulating Kv2.1 in response to stimulation by dopaminergic, muscarinic and other modulatory signaling pathways crucial to regulating the physiology of MSNs."
24962901
KCNB1 affects NEDD4L
2 |
KCNB1 binds NEDD4L. 2 / 2
2 |
biogrid
No evidence text available
19953087
biogrid
No evidence text available
19953087
KCNB1 affects Lys-Val
| 2
KCNB1 activates Lys-Val. 2 / 2
| 2
reach
"Expression of KCNB1 appears reduced in T2D islets, and further knockdown of KCNB1 does not inhibit Kv current in T2D beta-cells."
28607108
reach
"In beta-cells from donors with T2D, we find that Kv currents are similar to those from ND donors (XREF_FIG), although knockdown of either KCNB1 (XREF_FIG) or KCNB2 (XREF_FIG) now fail to inhibit Kv currents."
28607108
KCNB1 affects IL1RL1
| 2
IL1RL1 binds KCNB1. 1 / 1
| 1
sparser
"Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation."
19074135
KCNG3 binds KCNG4, IL1RL1, and KCNB1. 1 / 1
| 1
sparser
"Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation."
19074135
KCNB1 affects GNPTAB
| 2
GNPTAB binds KCNB1. 1 / 1
| 1
sparser
"Investigations of inactivation properties of heteromeric channels resulting from the association of other modulatory α -subunits with Kv2.1 have produced a variety of results."
10388754
GNPTAB binds KCNB1 and KCNG1. 1 / 1
| 1
sparser
"Protein-protein interactions between Kv2.1 and electrically silent Kv6.1 a-subunits were detected using two microelectrode voltage clamp and yeast two-hybrid measurements."
8980147
KCNB1 affects GDF15
| 2
GDF15 binds KCNB1. 2 / 2
| 2
sparser
"Taken together, our observations suggest that the effect of GDF15 on Kv2.1 expression may be developmentally regulated and associated with neuronal maturation."
24597762
sparser
"Thus we used TGFβR1 (ALK5) inhibitors (LY364947, SB431542 and PP1) and TGFβR1/TGFβR2 dual inhibitors (PP2 and LY2109761) to determine whether the effect of GDF15 on Kv2.1 expression was associated with the TGFβR1–TGFβR2 heterodimer complex [ xref ]."
24597762
IL1RL1 affects KCNB1
| 2
IL1RL1 binds KCNB1. 1 / 1
| 1
sparser
"Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation."
19074135
KCNG3 binds KCNG4, IL1RL1, and KCNB1. 1 / 1
| 1
sparser
"Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation."
19074135
Hanatoxin affects KCNB1
| 2
Hanatoxin inhibits KCNB1. 2 / 2
| 2
reach
"We studied the mechanism by which Hanatoxin (HaTx) inhibits the drk1 voltage gated K+ channel."
9136774
reach
"Hanatoxin inhibits the drk1 voltage gated K + channel by shifting activation to more depolarized voltages (Swartz and MacKinnon 1997a)."
10828242
GNPTAB affects KCNB1
| 2
GNPTAB binds KCNB1. 1 / 1
| 1
sparser
"Investigations of inactivation properties of heteromeric channels resulting from the association of other modulatory α -subunits with Kv2.1 have produced a variety of results."
10388754
GNPTAB binds KCNB1 and KCNG1. 1 / 1
| 1
sparser
"Protein-protein interactions between Kv2.1 and electrically silent Kv6.1 a-subunits were detected using two microelectrode voltage clamp and yeast two-hybrid measurements."
8980147
GIP affects KCNB1
| 2
GIP phosphorylates KCNB1.
| 1
GIP phosphorylates KCNB1. 1 / 1
| 1
sparser
"In studies designed to identify their mode of action, both GIP and GLP‐1 promoted phosphorylation and acetylation of Kv2.1 through pathways involving PKA, and/or MSK‐1 and HAT ( xref )."
24843552
GIP acetylates KCNB1.
| 1
GIP acetylates KCNB1. 1 / 1
| 1
sparser
"In studies designed to identify their mode of action, both GIP and GLP‐1 promoted phosphorylation and acetylation of Kv2.1 through pathways involving PKA, and/or MSK‐1 and HAT ( xref )."
24843552
GDF15 affects KCNB1
| 2
GDF15 binds KCNB1. 2 / 2
| 2
sparser
"Taken together, our observations suggest that the effect of GDF15 on Kv2.1 expression may be developmentally regulated and associated with neuronal maturation."
24597762
sparser
"Thus we used TGFβR1 (ALK5) inhibitors (LY364947, SB431542 and PP1) and TGFβR1/TGFβR2 dual inhibitors (PP2 and LY2109761) to determine whether the effect of GDF15 on Kv2.1 expression was associated with the TGFβR1–TGFβR2 heterodimer complex [ xref ]."
24597762
CDK5 affects KCNB1
| 2 1
CDK5 phosphorylates KCNB1. 2 / 2
| 2 1
rlimsp
"Here, we show that cyclin-dependent kinase 5 (CDK5), a Pro-directed Ser/Thr protein kinase, directly phosphorylates Kv2.1, and determines the constitutive level of Kv2.1 phosphorylation, the rapid increase in Kv2.1 phosphorylation upon acute blockade of neuronal activity, and the recovery of Kv2.1 phosphorylation after stimulus-induced dephosphorylation."
21712386
rlimsp
"Recently, cyclin-dependent kinase 5 (Cdk5) was shown to phosphorylate Kv2.1, with pharmacological Cdk5 inhibition being sufficient to decluster channels."
24647953
BDM affects KCNB1
| 2
BDM inhibits KCNB1. 2 / 2
| 2
reach
"In two-microelectrode voltage-clamp experiments, the application of BDM to the bath inhibited DRK1 current (ki = 16.6 mM, H = 0.96) rapidly and reversibly, with a time course similar to the time course of solution change within the bath."
8496800
reach
"Instead, the results suggest that BDM can inhibit DRK1 channels directly from inside or outside of the membrane."
8496800
Polypeptide affects KCNB1
| 1
KCNB1 binds polypeptide. 1 / 1
| 1
sparser
"Although there are a number of theoretical explanations for these observations, the most likely is that the C-terminal domain of Kv2.1 is capable of associating with the full-length channel polypeptide so as to produce inactive heteromultimeric assemblies, comprising full-length channel polypeptide and terminal polypeptide fragments."
10209222
Nicotine affects KCNB1
1 |
Nicotine decreases the amount of KCNB1. 1 / 1
1 |
bel
"Table 2b Genes whose expression is decreased by nicotine stimulation"
11328964
MtnN affects KCNB1
| 1
KCNB1 binds mtnN. 1 / 1
| 1
sparser
"The KCNB1 -high group was associated with favorable OS (median OS = 27.9 months, 95% confidence interval [CI] = 15.8 to 39.9 months; vs median OS = 12.5 months, 95% CI = 9.7 to 15.3 months; hazard ratio [HR] = 2.2, 95% CI = 1.35 to 3.5; p  < 0.001, two-sided log-rank test, Fig.  xref ) and PFS (median PFS = 20.3 months, 95% confidence interval [CI] = 12.9 to 27.6 months; vs median PFS = 9.3 months, 95% CI = 5.7 to 13.0 months; hazard ratio [HR] = 2.0, 95% CI = 1.2 to 3.3; p  < 0.05, two-sided log-rank test, Fig.  xref )."
28144039
LuxY affects KCNB1
| 1
LuxY sumoylates KCNB1. 1 / 1
| 1
sparser
"Consistent with sumoylation of CFP-Kv2.1 by YFP-SUMO1 101 , their coexpression produced donor photobleaching time constants >20 s."
21518833
Hsa-miR-93-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-93-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-7850-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-7850-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-7-2-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-7-2-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-7-1-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-7-1-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6871-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-6871-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6867-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-6867-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6832-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-6832-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6818-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-6818-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6776-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-6776-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-6739-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-6739-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6733-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-6733-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6505-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-6505-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-582-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-582-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-574-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-574-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-570-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-570-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-5589-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-5589-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-5580-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-5580-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-552-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-552-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-548t-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-548t-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-548c-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-548c-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-548ap-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-548ap-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-548ah-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-548ah-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-548aa affects KCNB1
1 |
Transcriptionally active hsa-miR-548aa decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-526b-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-526b-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-520f-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-520f-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-519d-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-519d-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-519c-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-519c-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-519b-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-519b-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-519a-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-519a-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-514b-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-514b-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-514a-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-514a-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-512-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-512-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-5011-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-5011-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4796-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-4796-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4696 affects KCNB1
1 |
Transcriptionally active hsa-miR-4696 decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4668-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-4668-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4639-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-4639-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-454-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-454-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4473 affects KCNB1
1 |
Transcriptionally active hsa-miR-4473 decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4295 affects KCNB1
1 |
Transcriptionally active hsa-miR-4295 decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3666 affects KCNB1
1 |
Transcriptionally active hsa-miR-3666 decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3613-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-3613-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3609 affects KCNB1
1 |
Transcriptionally active hsa-miR-3609 decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3153 affects KCNB1
1 |
Transcriptionally active hsa-miR-3153 decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3117-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-3117-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-302c-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-302c-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-301b-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-301b-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-301a-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-301a-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-210-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-210-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-20b-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-20b-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-20a-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-20a-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-190a-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-190a-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-17-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-17-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-153-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-153-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-147a affects KCNB1
1 |
Transcriptionally active hsa-miR-147a decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-130b-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-130b-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-130a-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-130a-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-1305 affects KCNB1
1 |
Transcriptionally active hsa-miR-1305 decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-129-2-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-129-2-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-129-1-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-129-1-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-1277-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-1277-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1250-3p affects KCNB1
1 |
Transcriptionally active hsa-miR-1250-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-106b-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-106b-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-106a-5p affects KCNB1
1 |
Transcriptionally active hsa-miR-106a-5p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-let-7i-3p affects KCNB1
1 |
Transcriptionally active hsa-let-7i-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-let-7g-3p affects KCNB1
1 |
Transcriptionally active hsa-let-7g-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-let-7a-2-3p affects KCNB1
1 |
Transcriptionally active hsa-let-7a-2-3p decreases the amount of KCNB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Grammotoxin affects KCNB1
| 1
KCNB1 binds grammotoxin. 1 / 1
| 1
reach
"Furthermore, binding of grammotoxin to drk1 K + channels can be greatly reduced by altering residues within the S3-S4 linker that also affect hanatoxin binding (Swartz and MacKinnon, 1997a, b), and conversely, the rabbit alpha 1A Ca 2+ channel can be inhibited by hanatoxin, a selective K + channel blocker."
10049321
Glucose affects KCNB1
| 1
Glucose dephosphorylates KCNB1. 1 / 1
| 1
sparser
"For example, glucose induced the de-phosphorylation of Ca 2+ -dependent protein phosphatase calcineurin target site on voltage-gated potassium channel Kv2.1 ( Kcnb1 ), which would activate this K + channel and increase outward K + currents thus impaired insulin exocytosis xref ."
28432305
Chemical modifier affects KCNB1
| 1
Chemical modifier inhibits KCNB1. 1 / 1
| 1
sparser
"Importantly, several gating modifier peptides inhibit Kv2.1 channels in a relatively specific fashion."
17101164
Calcineurin affects KCNB1
| 1
KCNB1 binds calcineurin. 1 / 1
| 1
sparser
"Calcineurin-mediated dephosphorylation of Kv2.1 is also associated with hyperpolarizing shifts in the voltage-dependent activation of Kv2.1 currents ( xref ; xref ; xref ; xref ), which constitute the majority (>70%) of I DR in hippocampal neurons ( xref ; xref )."
23223293
Butane-2,3-dione affects KCNB1
| 1
Butane-2,3-dione inhibits KCNB1. 1 / 1
| 1
reach
"Lopatin A. N. and Nichols C. G. (1993) 2,3-Butanedione monoxime (BDM) inhibition of delayed rectifier DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes."
8570023
Antagonist affects KCNB1
| 1
Antagonist inhibits KCNB1. 1 / 1
| 1
sparser
"To investigate whether this Kv2.1 inhibition by σ1-R antagonists was truly mediated by σ1-R, we used the CRISPR/Cas9 technology to specifically knock out the σ1-R protein in Kv2.1-overexpressing HEK293 cells."
28938641
VSTM2A affects KCNB1
| 1
VSTM2A inhibits KCNB1. 1 / 1
| 1
reach
"There are 1403 DEGs uniquely identified in ER + HER2 - BC including the top 10 up-regulated genes : CBLN2, SLC30A8, VSTM2A, GRM4, FOX11, RIMS4, SERPINA12, SYT1, IGFL1 and EEF1A2; and the top 10 down-regulated genes : FGFBP2, SPHKAP, XDH, SLC22A3, SLCO1B7, KCNB1, SERTM1, AKR1B15, ACSL1 and BMP3 (XREF_SUPPLEMENTARY)."
30089167
VAPs affects KCNB1
| 1
KCNB1 binds VAPs. 1 / 1
| 1
reach
"Here serine phosphorylation adjacent to the Kv2.1 C-terminal FFAT motif allows channel binding to VAPs present on the cytoplasmic surface of ER."
30712450
VAPA affects KCNB1
| 1
VAPA binds KCNB1. 1 / 1
| 1
sparser
"The association of VAPA with Kv2.1 relies on a "two phenylalanines in an Acidic Tract" (FFAT) binding domain on VAPA, and a non-canonical phosphorylation-dependent FFAT motif comprising the Kv2-specific clustering or PRC motif."
30012696
TRAPPC9 affects KCNB1
| 1
TRAPPC9 binds KCNB1. 1 / 1
| 1
sparser
"Comparative study performed with wild-type and mutant Kv2.1, wild-type Kv1.5, and chimeric Kv1.5N/Kv2.1 channels revealed that VAMP2 enhanced the inactivation of Kv2.1, but not of Kv1.5, via direct interaction with the T1 domain of the N terminus of Kv2.1."
18542995
SYT1 affects KCNB1
| 1
SYT1 inhibits KCNB1. 1 / 1
| 1
reach
"There are 1403 DEGs uniquely identified in ER + HER2 - BC including the top 10 up-regulated genes : CBLN2, SLC30A8, VSTM2A, GRM4, FOX11, RIMS4, SERPINA12, SYT1, IGFL1 and EEF1A2; and the top 10 down-regulated genes : FGFBP2, SPHKAP, XDH, SLC22A3, SLCO1B7, KCNB1, SERTM1, AKR1B15, ACSL1 and BMP3 (XREF_SUPPLEMENTARY)."
30089167
SUMO3 affects KCNB1
| 1
SUMO3 binds KCNB1. 1 / 1
| 1
sparser
"Photobleaching of the acceptor (leading to increased donor fluorescence) revealed close interaction of native Kv2.1 and SUMO2/3 ( xref ) in three subcellular locales: within Kv2.1 clusters (open arrow), at the periphery of Kv2.1 clusters (solid arrow), and at the surface distant from clusters (arrowhead)."
21518833
SUMO1 affects KCNB1
| 1
SUMO1 sumoylates KCNB1. 1 / 1
| 1
sparser
"Consistent with sumoylation of CFP-Kv2.1 by YFP-SUMO1 101 , their coexpression produced donor photobleaching time constants >20 s."
21518833
SOX10 affects KCNB1
| 1
SOX10 activates KCNB1. 1 / 1
| 1
reach
"Using Ingenuity Pathway Analysis (IPA; https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis), we found that TCF7L2 was predicted as a positive regulator of a broad variety of glial differentiation associated genes, including several that have been reported to regulate K + channel gene expression - for instance, the SOX10 modulated KCNB1, which was down-regulated in hGPCs derived from all three of our tested HD lines."
30554964
SLC30A8 affects KCNB1
| 1
SLC30A8 inhibits KCNB1. 1 / 1
| 1
reach
"There are 1403 DEGs uniquely identified in ER + HER2 - BC including the top 10 up-regulated genes : CBLN2, SLC30A8, VSTM2A, GRM4, FOX11, RIMS4, SERPINA12, SYT1, IGFL1 and EEF1A2; and the top 10 down-regulated genes : FGFBP2, SPHKAP, XDH, SLC22A3, SLCO1B7, KCNB1, SERTM1, AKR1B15, ACSL1 and BMP3 (XREF_SUPPLEMENTARY)."
30089167
SIGMAR1 affects KCNB1
| 1
KCNB1 binds SIGMAR1. 1 / 1
| 1
sparser
"The study indeed describes a functional interaction between Sig1R, Kv2.1 and a G-protein coupled receptor (GPCR): the mu-opoid receptor (He et al., xref )."
23882221
SERPINA12 affects KCNB1
| 1
SERPINA12 inhibits KCNB1. 1 / 1
| 1
reach
"There are 1403 DEGs uniquely identified in ER + HER2 - BC including the top 10 up-regulated genes : CBLN2, SLC30A8, VSTM2A, GRM4, FOX11, RIMS4, SERPINA12, SYT1, IGFL1 and EEF1A2; and the top 10 down-regulated genes : FGFBP2, SPHKAP, XDH, SLC22A3, SLCO1B7, KCNB1, SERTM1, AKR1B15, ACSL1 and BMP3 (XREF_SUPPLEMENTARY)."
30089167
S1R affects KCNB1
| 1
S1R activates KCNB1. 1 / 1
| 1
sparser
"At the moment, it is unclear how the S1R might activate Kv2.1 and/or SK channels and thus decrease excitability."
25704013
RIMS4 affects KCNB1
| 1
RIMS4 inhibits KCNB1. 1 / 1
| 1
reach
"There are 1403 DEGs uniquely identified in ER + HER2 - BC including the top 10 up-regulated genes : CBLN2, SLC30A8, VSTM2A, GRM4, FOX11, RIMS4, SERPINA12, SYT1, IGFL1 and EEF1A2; and the top 10 down-regulated genes : FGFBP2, SPHKAP, XDH, SLC22A3, SLCO1B7, KCNB1, SERTM1, AKR1B15, ACSL1 and BMP3 (XREF_SUPPLEMENTARY)."
30089167
REG1A affects KCNB1
| 1
REG1A dephosphorylates KCNB1. 1 / 1
| 1
trips
"We have previously shown that dephosphorylation of Kv2.1 by the nonreceptor-type tyrosine phosphatase PTPepsilon (cyt-PTPepsilon) down-regulates channel activity and counters its phosphorylation and up-regulation by Src or Fyn."
12615930
PPP1 affects KCNB1
| 1
PPP1 dephosphorylates KCNB1. 1 / 1
| 1
sparser
"Dephosphorylation of Kv2.1 by PP1 in response to synaptic activity results in substantial shifts in the inactivation curve of IK, resulting in a reduction in intrinsic excitability, facilitating negative feedback to neuronal excitability."
25220706
PKA affects KCNB1
| 1
PKA activates KCNB1. 1 / 1
| 1
reach
"These results indicate that phosphorylation via protein kinase A modulates drk1 channel function and that both consensus phosphorylation sites seems to be essential for channels to function."
7971176
NAV1 affects KCNB1
| 1
NAV1 binds KCNB1. 1 / 1
| 1
sparser
"The bioactive surfaces of JZTX-III interacting with Kv2.1 and Nav1.5 are only partially overlapping."
24044413
N-methyl-D-aspartic acid affects KCNB1
| 1
N-methyl-D-aspartic acid dephosphorylates KCNB1. 1 / 1
| 1
sparser
"Kv2.1 dephosphorylation induced by either NMDA or DHK was significantly attenuated by ethanol ( xref )."
19185209
MAPK14 affects KCNB1
1 |
MAPK14 phosphorylates KCNB1 on S805. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
LGI1 affects KCNB1
| 1
LGI1 inhibits KCNB1. 1 / 1
| 1
sparser
"Partial inactivation of Aplysia Kv2.1 during repetitive firing produces frequency-dependent broadening of action potentials during the afterdischarge."
18276591
KCNB1 affects positive regulation of wound healing
| 1
KCNB1 inhibits positive regulation of wound healing. 1 / 1
| 1
reach
"Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury."
27798188
KCNB1 affects polypeptide
| 1
KCNB1 binds polypeptide. 1 / 1
| 1
sparser
"Although there are a number of theoretical explanations for these observations, the most likely is that the C-terminal domain of Kv2.1 is capable of associating with the full-length channel polypeptide so as to produce inactive heteromultimeric assemblies, comprising full-length channel polypeptide and terminal polypeptide fragments."
10209222
KCNB1 affects mtnN
| 1
KCNB1 binds mtnN. 1 / 1
| 1
sparser
"The KCNB1 -high group was associated with favorable OS (median OS = 27.9 months, 95% confidence interval [CI] = 15.8 to 39.9 months; vs median OS = 12.5 months, 95% CI = 9.7 to 15.3 months; hazard ratio [HR] = 2.2, 95% CI = 1.35 to 3.5; p  < 0.001, two-sided log-rank test, Fig.  xref ) and PFS (median PFS = 20.3 months, 95% confidence interval [CI] = 12.9 to 27.6 months; vs median PFS = 9.3 months, 95% CI = 5.7 to 13.0 months; hazard ratio [HR] = 2.0, 95% CI = 1.2 to 3.3; p  < 0.05, two-sided log-rank test, Fig.  xref )."
28144039
KCNB1 affects localization
| 1
KCNB1 inhibits localization. 1 / 1
| 1
reach
"A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization."
26503721
KCNB1 affects integrin-FAK-Src
| 1
KCNB1 activates integrin-FAK-Src. 1 / 1
| 1
reach
"Together these data led us to conclude that KCNB1 oligomers activate an integrin-FAK-Src and Fyn apoptotic pathway that is conserved in both primary hippocampal neurons and mammalian cells."
28383553
KCNB1 affects inflammatory response
| 1
KCNB1 activates inflammatory response. 1 / 1
| 1
reach
"KCNB1 oxidation promotes inflammation, oxidative stress, neuronal apoptosis, and behavioral deficit in mouse model of traumatic brain injury a condition that, likewise AD, is associated to copious release of ROS 7."
30050035
KCNB1 affects grammotoxin
| 1
KCNB1 binds grammotoxin. 1 / 1
| 1
reach
"Furthermore, binding of grammotoxin to drk1 K + channels can be greatly reduced by altering residues within the S3-S4 linker that also affect hanatoxin binding (Swartz and MacKinnon, 1997a, b), and conversely, the rabbit alpha 1A Ca 2+ channel can be inhibited by hanatoxin, a selective K + channel blocker."
10049321
KCNB1 affects cell migration
| 1
KCNB1 inhibits cell migration. 1 / 1
| 1
reach
"These KCNB1+ subclones showed a reduced rate of cell proliferation and wound healing, indicating that KCNB1 expression leads to both growth inhibition and attenuated cell migration."
28144039
KCNB1 affects cell death
| 1
KCNB1 activates cell death. 1 / 1
| 1
reach
"However, oligomerization is only one mechanism by which KCNB1 promotes cell death; other mechanisms have also been amply demonstrated and will not be discussed here [XREF_BIBR - XREF_BIBR]."
27114846
KCNB1 affects calcineurin
| 1
KCNB1 binds calcineurin. 1 / 1
| 1
sparser
"Calcineurin-mediated dephosphorylation of Kv2.1 is also associated with hyperpolarizing shifts in the voltage-dependent activation of Kv2.1 currents ( xref ; xref ; xref ; xref ), which constitute the majority (>70%) of I DR in hippocampal neurons ( xref ; xref )."
23223293
KCNB1 affects aroA
| 1
KCNB1 inhibits aroA. 1 / 1
| 1
reach
"Consequently, the deficient expression KCNS3 and KCNB1 mRNAs in PV neurons, if reflected in a lower complement of Kv2.1/Kv9.3 channels, would be predicted to slow the time course of EPSPs in PV neurons, impairing their ability to appropriately generate gamma oscillations, and thus contribute to cognitive dysfunction in schizophrenia [XREF_BIBR]."
24650500
KCNB1 affects VAPs
| 1
KCNB1 binds VAPs. 1 / 1
| 1
reach
"Here serine phosphorylation adjacent to the Kv2.1 C-terminal FFAT motif allows channel binding to VAPs present on the cytoplasmic surface of ER."
30712450
KCNB1 affects VAPA
| 1
VAPA binds KCNB1. 1 / 1
| 1
sparser
"The association of VAPA with Kv2.1 relies on a "two phenylalanines in an Acidic Tract" (FFAT) binding domain on VAPA, and a non-canonical phosphorylation-dependent FFAT motif comprising the Kv2-specific clustering or PRC motif."
30012696
KCNB1 affects TRAPPC9
| 1
TRAPPC9 binds KCNB1. 1 / 1
| 1
sparser
"Comparative study performed with wild-type and mutant Kv2.1, wild-type Kv1.5, and chimeric Kv1.5N/Kv2.1 channels revealed that VAMP2 enhanced the inactivation of Kv2.1, but not of Kv1.5, via direct interaction with the T1 domain of the N terminus of Kv2.1."
18542995
KCNB1 affects TEA
| 1
KCNB1 binds TEA. 1 / 1
| 1
sparser
"[K + ] Dependence of the Interaction of Internal TEA with Wild-Type Kv2.1."
10352033
KCNB1 affects SUMO3
| 1
SUMO3 binds KCNB1. 1 / 1
| 1
sparser
"Photobleaching of the acceptor (leading to increased donor fluorescence) revealed close interaction of native Kv2.1 and SUMO2/3 ( xref ) in three subcellular locales: within Kv2.1 clusters (open arrow), at the periphery of Kv2.1 clusters (solid arrow), and at the surface distant from clusters (arrowhead)."
21518833
KCNB1 affects SRC, and p38
| 1
P38 binds SRC and KCNB1. 1 / 1
| 1
sparser
"In previous studies [ xref , xref ], we reported that the phosphorylation of Kv2.1 by Src and p38 kinases is associated with oxidant-triggered apoptotic K + current surges in transfected CHO cells."
26115091
KCNB1 affects SNAP25, and syntaxin
| 1
SNAP25 binds KCNB1 and syntaxin. 1 / 1
| 1
sparser
"Of interest, Kv2.1 binds to both syntaxin and SNAP-25 in vitro and thus has been postulated to be directly involved in membrane fusion events ( xref ; xref )."
22648171
KCNB1 affects SIGMAR1
| 1
KCNB1 binds SIGMAR1. 1 / 1
| 1
sparser
"The study indeed describes a functional interaction between Sig1R, Kv2.1 and a G-protein coupled receptor (GPCR): the mu-opoid receptor (He et al., xref )."
23882221
KCNB1 affects Plekhg5, and SNAP25
| 1
SNAP25 binds KCNB1 and Plekhg5. 1 / 1
| 1
sparser
"We also demonstrated physical interactions in neuroendocrine cells between Kv2.1, Syx, and SNAP-25, characterized their effects on Kv2.1 activation and inactivation in Xenopus laevis oocytes, and suggested that they pertain to the assembly/disassembly of the Syx/SNAP-25 (t-SNARE) complex."
15525758
KCNB1 affects Plekhg5, and SNAP receptor activity
| 1
SNAP receptor activity binds KCNB1 and Plekhg5. 1 / 1
| 1
sparser
"Taken together, these findings suggest that physical interactions of both Syx and the t-SNARE complex with the C terminus of Kv2.1 are involved in channel regulation."
15525758
KCNB1 affects Phylogenetic Species 2
| 1
KCNB1 activates Phylogenetic Species 2. 1 / 1
| 1
reach
"Four of seven single gene phylogenies examined (chs2, drk1, pyrF, and its-2) supported the separation of Phylogenetic Species 1 (PS1) and Phylogenetic Species 2 (PS2) which were also well differentiated in the concatenated chs2-drk1-fads-pyrF-tub1-arf6-its2 genealogy with all isolates falling into one of two evolutionarily independent lineages."
23533607
KCNB1 affects Phylogenetic Species 1
| 1
KCNB1 activates Phylogenetic Species 1. 1 / 1
| 1
reach
"Four of seven single gene phylogenies examined (chs2, drk1, pyrF, and its-2) supported the separation of Phylogenetic Species 1 (PS1) and Phylogenetic Species 2 (PS2) which were also well differentiated in the concatenated chs2-drk1-fads-pyrF-tub1-arf6-its2 genealogy with all isolates falling into one of two evolutionarily independent lineages."
23533607
KCNB1 affects PSEN1
| 1
KCNB1 activates PSEN1. 1 / 1
| 1
reach
"Four of seven single gene phylogenies examined (chs2, drk1, pyrF, and its-2) supported the separation of Phylogenetic Species 1 (PS1) and Phylogenetic Species 2 (PS2) which were also well differentiated in the concatenated chs2-drk1-fads-pyrF-tub1-arf6-its2 genealogy with all isolates falling into one of two evolutionarily independent lineages."
23533607
KCNB1 affects PPP6C
| 1
KCNB1 dephosphorylates PPP6C. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects PPP2CB
| 1
KCNB1 dephosphorylates PPP2CB. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects PPP2CA
| 1
KCNB1 dephosphorylates PPP2CA. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects PPP1CB
| 1
KCNB1 dephosphorylates PPP1CB. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects PPP1CA
| 1
KCNB1 dephosphorylates PPP1CA. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects PPM1G
| 1
KCNB1 dephosphorylates PPM1G. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects PPM1D
| 1
KCNB1 dephosphorylates PPM1D. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects PPM1B
| 1
KCNB1 dephosphorylates PPM1B. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects PPEF1
| 1
KCNB1 dephosphorylates PPEF1. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects PHLPP1
| 1
KCNB1 dephosphorylates PHLPP1. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects PDP2
| 1
KCNB1 dephosphorylates PDP2. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects PCID:21618712, and STX1A
| 1
STX1A binds KCNB1 and PCID:21618712. 1 / 1
| 1
sparser
"We have obtained evidence that syntaxin-1A physically interacts with Kv2.1 (the predominant Kv in beta-cells) and the sulfonylurea receptor subunit of beta-cell K(ATP) channel to modify their gating behaviors."
17878408
KCNB1 affects NMDAR
| 1
KCNB1 binds NMDAR. 1 / 1
| 1
sparser
"Surprisingly, hyperactivation of synaptic NMDA receptors was not associated with changes in Kv2.1 dephosphorylation ( xref ), voltage-dependency for activation of I K ( xref ), cell capacitance, current density, or membrane-associated Kv2.1 protein levels ( xref )."
18753382
KCNB1 affects NAV1
| 1
NAV1 binds KCNB1. 1 / 1
| 1
sparser
"The bioactive surfaces of JZTX-III interacting with Kv2.1 and Nav1.5 are only partially overlapping."
24044413
KCNB1 affects Kv2.1 channel
| 1
KCNB1 activates Kv2.1 channel. 1 / 1
| 1
reach
"8 Patch-clamp studies have demonstrated that some KCNB1 variants cause significant alterations of Kv2.1 channel function and increased excitability of cortical neurons."
29264397
KCNB1 affects KCNIP2, and RBPJ
| 1
KCNIP2 binds RBPJ and KCNB1. 1 / 1
| 1
sparser
"Notch activation resulted in over 3.5 fold enrichment of RBP-J binding at both the Kcnip2 ( P = 0.003) and Kcnb1 ( P = 0.001 ) promoters ( xref ), consistent with a Notch-regulated dynamic binding profile."
27697822
KCNB1 affects KCNIP2, NOTCH1, and RBPJ
| 1
KCNIP2 binds RBPJ, KCNB1, and NOTCH1. 1 / 1
| 1
sparser
"In contrast to the dynamic RBP-J binding to Kcnip2 and Kcnb1 promoters in the presence of NICD ( xref ), we did not detect an increase in RBP-J binding to the Hrt2 promoter and enhancer sites in LV nor RV in the presence of NICD ( xref )."
27697822
KCNB1 affects KCNE5
1 | 4
KCNB1 binds KCNE5. 1 / 1
1 | 4
biogrid
No evidence text available
26242757
KCNB1 affects HaTx1
| 1
KCNB1 binds HaTx1. 1 / 1
| 1
sparser
"If the model of HaTx1-VS R shown in xref A were representative of the binding of HaTx1 to Kv2.1 in real systems, the model should be able to reproduce the effect of single mutation to the VS on toxin binding observed experimentally."
23250329
KCNB1 affects GSC
| 1
KCNB1 inhibits GSC. 1 / 1
| 1
reach
"SCN8A, KCNB1, or GRIA3 knockdown reduces GSC viability."
28264064
KCNB1 affects FOXH1
| 1
KCNB1 inhibits FOXH1. 1 / 1
| 1
sparser
"In the following, we show experimental evidence that the fast Kv2.1(4.2NT) inactivation bears features similar to the ones described for the N-type inactivation."
14695263
KCNB1 affects Epsilon
| 1
KCNB1 binds Epsilon. 1 / 1
| 1
sparser
"Kv2.1 associates with a substrate-trapping mutant of PTP epsilon, and PTP epsilon profoundly reduces Src- or Fyn-stimulated Kv2.1 currents and tyrosine phosphorylation in transfected HEK 293 cells."
10921884
KCNB1 affects ERK
| 1
KCNB1 phosphorylates ERK. 1 / 1
| 1
sparser
"Not only did pretreatment with U0126 inhibit the KCNB1 induced ERK1/2 phosphorylation, but it also decreased the level of LC3II conversion (Fig.  xref )."
28144039
KCNB1 affects ER
| 1
KCNB1 binds ER. 1 / 1
| 1
reach
"Thus, Kv2.1 channel bound to the ER is corralled by the edge of the ER membrane at the point where this organelle turns inward towards the more internal cytoplasm."
30712450
KCNB1 affects DUSP1
| 1
KCNB1 dephosphorylates DUSP1. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects CTDNEP1
| 1
KCNB1 dephosphorylates CTDNEP1. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects CDC14B
| 1
KCNB1 dephosphorylates CDC14B. 1 / 1
| 1
sparser
"The increased levels of intracellular calcium arising from neuronal activity lead to activation of the protein phosphatase calcineurin and Kv2.1 dephosphorylation ( xref , xref )."
21518832
KCNB1 affects CALM1
1 |
CALM1 binds KCNB1. 1 / 1
1 |
biogrid
No evidence text available
26487174
KCNB1 affects CABIN1
| 1
KCNB1 dephosphorylates CABIN1. 1 / 1
| 1
sparser
"The calcineurin inhibitor FK520 (0.01 – 5 μM) partially attenuated Kv2.1 dephosphorylation only at high concentrations ( xref ), and we did not observe any effect on NMDA dephosphorylation of Kv2.1 using the calcineurin inhibitor cypermethrin (0.01 – 5 μM) (data not shown)."
18753382
KCNA1 affects KCNB1, and STX1A
| 1
STX1A binds KCNA1 and KCNB1. 1 / 1
| 1
sparser
"Studies have shown that Syntaxin 1A interacts with both Kv2.1 and Kv1.1 and modulates the firing frequency of the pre-synaptic membrane ( xref ; xref )."
21797886
IL1RL1 affects KCNB1, KCNG3, and KCNG4
| 1
KCNG3 binds KCNG4, IL1RL1, and KCNB1. 1 / 1
| 1
sparser
"Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation."
19074135
IK affects KCNB1, and p38
| 1
P38 binds IK and KCNB1. 1 / 1
| 1
sparser
"Taken together, these results suggest that gp120 induces hippocampal neuron apoptosis by enhancement of the Ik, which might be associated with increased Kv2.1 expression via the p38 MAPK pathway."
26393286
IK affects KCNA2, and KCNB1
| 1
IK binds KCNA2 and KCNB1. 1 / 1
| 1
sparser
"Kv1.2 and Kv2.1 were associated with IK(DR); Slo and KCNN4 were associated with IK(Ca); and Kv1.4 and Kv4.3 were associated with Ito."
18505444
IGFL1 affects KCNB1
| 1
IGFL1 inhibits KCNB1. 1 / 1
| 1
reach
"There are 1403 DEGs uniquely identified in ER + HER2 - BC including the top 10 up-regulated genes : CBLN2, SLC30A8, VSTM2A, GRM4, FOX11, RIMS4, SERPINA12, SYT1, IGFL1 and EEF1A2; and the top 10 down-regulated genes : FGFBP2, SPHKAP, XDH, SLC22A3, SLCO1B7, KCNB1, SERTM1, AKR1B15, ACSL1 and BMP3 (XREF_SUPPLEMENTARY)."
30089167
HaTx1 affects KCNB1
| 1
KCNB1 binds HaTx1. 1 / 1
| 1
sparser
"If the model of HaTx1-VS R shown in xref A were representative of the binding of HaTx1 to Kv2.1 in real systems, the model should be able to reproduce the effect of single mutation to the VS on toxin binding observed experimentally."
23250329
Grammotoxin affects KCNB1
| 1
Grammotoxin inhibits KCNB1. 1 / 1
| 1
reach
"Grammotoxin, a gating modifier of the alpha1A voltage gated Ca 2+ channel, also inhibits the drk1 K + channel and the binding affinity of grammotoxin to the K + channel is altered by mutations at I273, F274, or E277 (Li-Smerin and Swartz 1998)."
10828242
GRM4 affects KCNB1
| 1
GRM4 inhibits KCNB1. 1 / 1
| 1
reach
"There are 1403 DEGs uniquely identified in ER + HER2 - BC including the top 10 up-regulated genes : CBLN2, SLC30A8, VSTM2A, GRM4, FOX11, RIMS4, SERPINA12, SYT1, IGFL1 and EEF1A2; and the top 10 down-regulated genes : FGFBP2, SPHKAP, XDH, SLC22A3, SLCO1B7, KCNB1, SERTM1, AKR1B15, ACSL1 and BMP3 (XREF_SUPPLEMENTARY)."
30089167
GNPTAB affects KCNB1, and KCNG1
| 1
GNPTAB binds KCNB1 and KCNG1. 1 / 1
| 1
sparser
"Protein-protein interactions between Kv2.1 and electrically silent Kv6.1 a-subunits were detected using two microelectrode voltage clamp and yeast two-hybrid measurements."
8980147
FYN affects KCNA5, and KCNB1
| 1
FYN binds KCNA5 and KCNB1. 1 / 1
| 1
sparser
"The Kv1.5 and Kv2.1 K+-channel alpha subunits are constitutively tyrosine phosphorylated and physically associate with Fyn both in cultured SCs and in the sciatic nerve in vivo."
9707431
FOXH1 affects KCNB1
| 1
FOXH1 inhibits KCNB1. 1 / 1
| 1
sparser
"Notably, Kv2.1(4.2NT) showed features typically observed for Shaker N-type inactivation: fast inactivation of Kv2.1(4.2NT) channels was slowed by intracellular tetraethylammonium and removed by N-terminal truncation (Delta40)."
14695263
FOX11 affects KCNB1
| 1
FOX11 inhibits KCNB1. 1 / 1
| 1
reach
"There are 1403 DEGs uniquely identified in ER + HER2 - BC including the top 10 up-regulated genes : CBLN2, SLC30A8, VSTM2A, GRM4, FOX11, RIMS4, SERPINA12, SYT1, IGFL1 and EEF1A2; and the top 10 down-regulated genes : FGFBP2, SPHKAP, XDH, SLC22A3, SLCO1B7, KCNB1, SERTM1, AKR1B15, ACSL1 and BMP3 (XREF_SUPPLEMENTARY)."
30089167
Epsilon affects KCNB1
| 1
KCNB1 binds Epsilon. 1 / 1
| 1
sparser
"Kv2.1 associates with a substrate-trapping mutant of PTP epsilon, and PTP epsilon profoundly reduces Src- or Fyn-stimulated Kv2.1 currents and tyrosine phosphorylation in transfected HEK 293 cells."
10921884
EXT1 affects GABRB3, and KCNB1
| 1
EXT1 binds GABRB3 and KCNB1. 1 / 1
| 1
sparser
"It is worth noting that LGS has also been associated with mutations in other genes such as GABRB3 and KCNB1 [ xref ] [ xref ]."
31176687
ER affects KCNB1
| 1
KCNB1 binds ER. 1 / 1
| 1
reach
"Thus, Kv2.1 channel bound to the ER is corralled by the edge of the ER membrane at the point where this organelle turns inward towards the more internal cytoplasm."
30712450
EEF1A2 affects KCNB1
| 1
EEF1A2 inhibits KCNB1. 1 / 1
| 1
reach
"There are 1403 DEGs uniquely identified in ER + HER2 - BC including the top 10 up-regulated genes : CBLN2, SLC30A8, VSTM2A, GRM4, FOX11, RIMS4, SERPINA12, SYT1, IGFL1 and EEF1A2; and the top 10 down-regulated genes : FGFBP2, SPHKAP, XDH, SLC22A3, SLCO1B7, KCNB1, SERTM1, AKR1B15, ACSL1 and BMP3 (XREF_SUPPLEMENTARY)."
30089167
Dizocilpine affects KCNB1
| 1
Dizocilpine dephosphorylates KCNB1. 1 / 1
| 1
sparser
"Indeed, our results showing attenuation of SDF-1α-induced [Ca 2+ ] i elevation and calcineurin-dependent dephosphorylation of Kv2.1 by the NMDA receptor antagonist MK-801 are consistent with these reports."
23223293
DCA affects KCNB1
| 1
DCA activates KCNB1. 1 / 1
| 1
sparser
"In a mammalian expression system, DCA activated Kv2.1 by a tyrosine kinase-dependent mechanism."
11790708
DAPK affects KCNB1
| 1
DAPK activates KCNB1. 1 / 1
| 1
reach
"The DAPK family also contains two distantly related kinases : DAPK related apoptosis inducing kinase 1 and 2 (DRK1 and DRK2) XREF_BIBR."
27312851
CBLN2 affects KCNB1
| 1
CBLN2 inhibits KCNB1. 1 / 1
| 1
reach
"There are 1403 DEGs uniquely identified in ER + HER2 - BC including the top 10 up-regulated genes : CBLN2, SLC30A8, VSTM2A, GRM4, FOX11, RIMS4, SERPINA12, SYT1, IGFL1 and EEF1A2; and the top 10 down-regulated genes : FGFBP2, SPHKAP, XDH, SLC22A3, SLCO1B7, KCNB1, SERTM1, AKR1B15, ACSL1 and BMP3 (XREF_SUPPLEMENTARY)."
30089167
CBD affects KCNB1
| 1
CBD inhibits KCNB1. 1 / 1
| 1
reach
"We also found that CBD inhibits other voltage dependent currents from diverse channels, including bacterial homomeric Nav channel (NaChBac) and voltage gated potassium channel subunit Kv2.1."
30219789
CALM1 affects KCNB1
1 |
CALM1 binds KCNB1. 1 / 1
1 |
biogrid
No evidence text available
26487174
C2 affects KCNB1, and syntaxin
| 1
C2 binds KCNB1 and syntaxin. 1 / 1
| 1
sparser
"In the presence of Kv2.1-C2 that binds syntaxin weakly xref , xref there was a relatively small and statistically insignificant reduction of release ( xref )."
18167541
C1 affects KCNB1, and STX1A
| 1
C1 binds STX1A and KCNB1. 1 / 1
| 1
sparser
"Previous in vitro binding studies, using immobilized glutathione S-transferase (GST) fusion peptides corresponding to the major cytoplasmic parts of Kv2.1 (depicted in xref ), showed that syntaxin 1A (syntaxin) binds Kv2.1 C-terminal C1 and C1a domains, but not the Kv2.1 N terminus xref ."
18167541
5-HT affects KCNB1
| 1
5-HT inhibits KCNB1. 1 / 1
| 1
sparser
"Additionally, 5-HT inhibition of Kv1.5, Kv2.1 and BK Ca channel proteins in PASMCs was reversed by KMUP-1 in a dose-dependent manner."
25999786
2,3-Butanedione monoxime affects KCNB1
| 1
2,3-Butanedione monoxime inhibits KCNB1. 1 / 1
| 1
reach
"2,3-Butanedione monoxime (BDM) inhibition of delayed rectifier DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes."
8496800
17beta-estradiol affects KCNB1
| 1
17beta-estradiol inhibits KCNB1. 1 / 1
| 1
sparser
"17beta-Estradiol inhibits Kv2.1 and IK of hippocampus at similar level."
15606014