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databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading

DLG1 affects KCNA5
2 2 | 1 13 1
DLG1 binds KCNA5.
2 2 | 1 13
2 2 | 1 11
hprd
No evidence text available
sparser
"SAP97 appeared to be largely distributed along Z-lines In order to further test whether or not Kv1.5 and SAP97 directly interact in atrial and/or ventricular myocytes, we conducted co-immunoprecipitation experiments."
biogrid
No evidence text available
sparser
"The results of all of the experiments described above are inconsistent with a typical PDZ–extreme C-terminal interaction between SAP97 and Kv1.5."
sparser
"Interestingly, SAP97 also interacts with the 3 last residues of Kv4.2/4.3 (Ser-Ala-Leu) and Kv1.5 (Thr-Asp-Val) to potentially target and/or anchor ion channels to cell surface [ xref – xref ]."
sparser
"This is unlikely to be due to detergent disruption of the Kv1.5SAP97 interaction."
sparser
"But even if SAP97 does bind the Kv1.5 C-terminus under specific conditions, that fact cannot explain the lack of dependence of the SAP97-mediated current enhancement on the extreme Kv1.5 C-terminus."
sparser
"For this reason, we examined the interaction between Kv1.5 and SAP97, a PDZ protein that is widely expressed in mammalian heart [20] ."
hprd
No evidence text available
sparser
"Indeed, given this stark difference in effects of SAP97 on most Kv1 channels versus its effect on Kv1.5, it would be surprising if SAP97 did in fact bind Kv1.5."
sparser
"Perhaps in COS-7 cells the state of the channel is permissive of a stable SAP97-Kv1.5 interaction that is not seen in other cell types (including heart)."
sparser
"SAP97 and Kv1.5 subunits can interact, directly or indirectly, both in the heart and in heterologous systems. xref , xref Adenoviral overexpression of SAP97 in neonatal rat atrial myocytes leads to clustering of endogenous Kv1.5 subunits at myocyte-myocyte contacts and an increase in both I Kur and the number of 4-aminopyridine-sensitive potassium channels in cell-attached membrane patches. xref On the other hand, pull-down and coimmunoprecipitation assays in cardiac myocytes showed that the Kv4 channel C terminus, SAP97, and CaMKII interact together, and that the interaction is suppressed by SAP97 silencing and enhanced by SAP97 overexpression. xref In HEK293 cells, SAP97 silencing reproduced the effects of CaMKII inhibition on current kinetics and suppressed Kv4/CaMKII interactions."
sparser
"It remains formally possible that Kv1.5 and SAP97 do directly interact but that the interaction is fleeting."
biogrid
No evidence text available
sparser
"The results presented here exclude a role of SAP97 binding to Kv1.5 in effecting the current enhancement and show that a specific N-terminal threonine residue (T15) is required in this phenomenon."
DLG1 binds DLG4 and KCNA5. 1 / 1
| 1
sparser
"PSD-95 and SAP97 interact with Kv1.5 and recruit channels to a complex which includes caveolin-3 ( xref ; xref )."
ACTN1 binds DLG1 and KCNA5. 1 / 1
| 1
sparser
"We found that both Kv1.5 and SAP97 interact strongly with α-actinin2."
DLG1 activates KCNA5.
| 1
DLG1 activates KCNA5. 1 / 1
| 1
reach
"In particular, overexpression of SAP97 increases surface levels of Kv1.5 XREF_BIBR, XREF_BIBR, XREF_BIBR and decreases other Kv channels 56, while CASK participates in the targeting of Kir2 channels 57."
STUB1 affects KCNA5
2 | 15
STUB1 binds KCNA5.
2 | 13
2 | 10
sparser
"Overexpression of Hsc70 intensified, but knockdown of Hsc70 diminished, the interaction of CHIP with Kv1.5 proteins ( Fig. 7 A)."
sparser
"Knockdown of Hsc70 diminished interaction of Kv1.5 with CHIP ( Fig. 6 B), indicating that CHIP requires Hsc70 to form a complex with Kv1.5 proteins."
sparser
"Myc-CHIP ∆TPR also showed decreased interaction with Kv1.5 ( Fig. 5 B), reflecting that the interaction of CHIP with Kv1.5 is Hsc70 dependent."
biogrid
No evidence text available
sparser
"Effects of Hsc70 on Kv1.5 were similar to CHIP by altering interaction of CHIP with Kv1.5 protein."
sparser
"The function of CHIP in Kv1.5 protein regulation was first suggested by immunoprecipitation studies that showed interaction of CHIP with Kv1.5 proteins ( Fig. 1 A)."
sparser
"Cooperation of STUB1 and HSC70 may lead to enhanced ubiquitination of genes, for example, HSC70 is required for STUB1 to form a complex with Kv1.5 proteins [36] ."
sparser
"Immunoprecipitation showed that CHIP formed complexes with Kv1.5 proteins and heat shock cognate protein 70 (Hsc70)."
sparser
"Our findings presented evidence that Kv1.5 is a substrate of CHIP, and that CHIP associates with Kv1.5 proteins to depress their expression and channel function."
sparser
"First, to examine whether the E3 ligase CHIP interacts with Kv1.5 protein, we introduced Kv1.5-FLAG and myc-CHIP WT into HEK 293 cells."
sparser
"The interaction of CHIP with Kv1.5 was enhanced by overexpressed Hsc70 but depressed by siRNA against Hsc70 ( Fig. 6 B, bottom), indicating that Hsc70 is indispensable for the CHIP activity."
biogrid
No evidence text available
STUB1 binds KCNA5 and MYC. 2 / 2
| 2
sparser
"Interaction with Kv1.5 of myc-CHIP ∆U was much less than that of myc-CHIP WT ( Fig. 5 B), whereas the interaction with Hsc70 remained unaltered ( Fig. 6 A, right panel)."
sparser
"Whereas myc-CHIP WT could form complexes with Kv1.5, myc-CHIP ∆TPR and myc-CHIP ∆U failed to interact with Kv1.5 ( Fig. 5 B)."
| 1
sparser
"Hsc70 formed complexes with CHIP and Kv1.5 proteins ( Fig. 6 A , left panel)."
STUB1 ubiquitinates KCNA5.
| 2
STUB1 ubiquitinates KCNA5. 2 / 2
| 2
sparser
"Co-expression of Hsc70 together with myc-CHIP WT enhanced ubiquitination of Kv1.5 more strongly than expression of CHIP or Hsc70 alone ( Fig. 6 C)."
sparser
"Thus, U-box domain plays an essential role in the CHIP-induced Kv1.5 ubiquitination."
KCNA5 affects DLG1
2 2 | 1 13
2 2 | 1 11
hprd
No evidence text available
sparser
"SAP97 appeared to be largely distributed along Z-lines In order to further test whether or not Kv1.5 and SAP97 directly interact in atrial and/or ventricular myocytes, we conducted co-immunoprecipitation experiments."
biogrid
No evidence text available
sparser
"The results of all of the experiments described above are inconsistent with a typical PDZ–extreme C-terminal interaction between SAP97 and Kv1.5."
sparser
"Interestingly, SAP97 also interacts with the 3 last residues of Kv4.2/4.3 (Ser-Ala-Leu) and Kv1.5 (Thr-Asp-Val) to potentially target and/or anchor ion channels to cell surface [ xref – xref ]."
sparser
"This is unlikely to be due to detergent disruption of the Kv1.5SAP97 interaction."
sparser
"But even if SAP97 does bind the Kv1.5 C-terminus under specific conditions, that fact cannot explain the lack of dependence of the SAP97-mediated current enhancement on the extreme Kv1.5 C-terminus."
sparser
"For this reason, we examined the interaction between Kv1.5 and SAP97, a PDZ protein that is widely expressed in mammalian heart [20] ."
hprd
No evidence text available
sparser
"Indeed, given this stark difference in effects of SAP97 on most Kv1 channels versus its effect on Kv1.5, it would be surprising if SAP97 did in fact bind Kv1.5."
sparser
"Perhaps in COS-7 cells the state of the channel is permissive of a stable SAP97-Kv1.5 interaction that is not seen in other cell types (including heart)."
sparser
"SAP97 and Kv1.5 subunits can interact, directly or indirectly, both in the heart and in heterologous systems. xref , xref Adenoviral overexpression of SAP97 in neonatal rat atrial myocytes leads to clustering of endogenous Kv1.5 subunits at myocyte-myocyte contacts and an increase in both I Kur and the number of 4-aminopyridine-sensitive potassium channels in cell-attached membrane patches. xref On the other hand, pull-down and coimmunoprecipitation assays in cardiac myocytes showed that the Kv4 channel C terminus, SAP97, and CaMKII interact together, and that the interaction is suppressed by SAP97 silencing and enhanced by SAP97 overexpression. xref In HEK293 cells, SAP97 silencing reproduced the effects of CaMKII inhibition on current kinetics and suppressed Kv4/CaMKII interactions."
sparser
"It remains formally possible that Kv1.5 and SAP97 do directly interact but that the interaction is fleeting."
biogrid
No evidence text available
sparser
"The results presented here exclude a role of SAP97 binding to Kv1.5 in effecting the current enhancement and show that a specific N-terminal threonine residue (T15) is required in this phenomenon."
DLG1 binds DLG4 and KCNA5. 1 / 1
| 1
sparser
"PSD-95 and SAP97 interact with Kv1.5 and recruit channels to a complex which includes caveolin-3 ( xref ; xref )."
ACTN1 binds DLG1 and KCNA5. 1 / 1
| 1
sparser
"We found that both Kv1.5 and SAP97 interact strongly with α-actinin2."
KCNA5 affects STUB1
2 | 13
2 | 10
sparser
"Overexpression of Hsc70 intensified, but knockdown of Hsc70 diminished, the interaction of CHIP with Kv1.5 proteins ( Fig. 7 A)."
sparser
"Knockdown of Hsc70 diminished interaction of Kv1.5 with CHIP ( Fig. 6 B), indicating that CHIP requires Hsc70 to form a complex with Kv1.5 proteins."
sparser
"Myc-CHIP ∆TPR also showed decreased interaction with Kv1.5 ( Fig. 5 B), reflecting that the interaction of CHIP with Kv1.5 is Hsc70 dependent."
biogrid
No evidence text available
sparser
"Effects of Hsc70 on Kv1.5 were similar to CHIP by altering interaction of CHIP with Kv1.5 protein."
sparser
"The function of CHIP in Kv1.5 protein regulation was first suggested by immunoprecipitation studies that showed interaction of CHIP with Kv1.5 proteins ( Fig. 1 A)."
sparser
"Cooperation of STUB1 and HSC70 may lead to enhanced ubiquitination of genes, for example, HSC70 is required for STUB1 to form a complex with Kv1.5 proteins [36] ."
sparser
"Immunoprecipitation showed that CHIP formed complexes with Kv1.5 proteins and heat shock cognate protein 70 (Hsc70)."
sparser
"Our findings presented evidence that Kv1.5 is a substrate of CHIP, and that CHIP associates with Kv1.5 proteins to depress their expression and channel function."
sparser
"First, to examine whether the E3 ligase CHIP interacts with Kv1.5 protein, we introduced Kv1.5-FLAG and myc-CHIP WT into HEK 293 cells."
sparser
"The interaction of CHIP with Kv1.5 was enhanced by overexpressed Hsc70 but depressed by siRNA against Hsc70 ( Fig. 6 B, bottom), indicating that Hsc70 is indispensable for the CHIP activity."
biogrid
No evidence text available
STUB1 binds KCNA5 and MYC. 2 / 2
| 2
sparser
"Interaction with Kv1.5 of myc-CHIP ∆U was much less than that of myc-CHIP WT ( Fig. 5 B), whereas the interaction with Hsc70 remained unaltered ( Fig. 6 A, right panel)."
sparser
"Whereas myc-CHIP WT could form complexes with Kv1.5, myc-CHIP ∆TPR and myc-CHIP ∆U failed to interact with Kv1.5 ( Fig. 5 B)."
| 1
sparser
"Hsc70 formed complexes with CHIP and Kv1.5 proteins ( Fig. 6 A , left panel)."
Sertraline affects KCNA5
| 12
| 12
sparser
"For an analysis of a frequency-dependent inhibition of Kv1.5 by sertraline without contamination of the decline of the current under control conditions, the relative currents (I Sertraline /I Control ) at 1 and 2 Hz were plotted ( xref )."
sparser
"The phospholipid composition of the cell may be different from human native cardiac myocytes and the differences of membrane composition may affect sertraline-induced Kv1.5 inhibition."
sparser
"The result of voltage-dependent inhibition of Kv1.5 by sertraline shows an additional low degree of inhibition detected in the voltage range positive to +10 mV despite Kv1.5 being fully activated at this voltage range ( xref )."
sparser
"To further investigate the time-dependent inhibition of Kv1.5 by sertraline, deactivation kinetics of Kv1.5 current was studied. xref shows the representative superimposed tail currents recorded with a 250-ms repolarizing pulse at –40 mV after a 250-ms depolarizing pulse of +50 mV from a holding potential of –80 mV, under control conditions and in the presence of 1 µM sertraline."
sparser
"3) The inhibition of Kv1.5 induced by sertraline was highly voltage-dependent and increased steeply in the voltage range of channel activation."
sparser
"Time-dependent inhibition of Kv1.5 by sertraline."
sparser
"Concentration-dependent and reversible inhibition of Kv1.5 by sertraline."
sparser
"In this study, the characteristics of the sertraline-induced inhibition of Kv1.5 suggest that sertraline preferentially interacts with the open state of Kv1.5 based on the following lines of evidence."
sparser
"The voltage-dependent inhibition of Kv1.5 by sertraline implies that the inhibition of Kv1.5 by sertraline occurs preferentially after the channels are open [ xref xref xref xref xref xref xref ]."
sparser
"Voltage-dependent inhibition of Kv1.5 by sertraline."
sparser
"Use- and frequency-dependent inhibition of Kv1.5 by sertraline."
sparser
"Inhibition of Kv1.5 by sertraline was use-dependent."
KCNA5 affects PSMD4
| 2 9
KCNA5 activates PSMD4.
| 5
KCNA5 activates PSMD4. 5 / 5
| 5
reach
"Functional mutations in the underlying KCNA5 gene have been shown to cause hereditary forms of atrial fibrillation (AF)."
reach
"Interestingly, both loss and gain-of-function mutations in KCNA5 have been shown to cause familial AF."
reach
"A recent study of more than 300 patients with early-onset lone AF revealed 3 " gain-of-function " mutations in KCNA5 in addition to several loss-of-function mutations, supporting the hypothesis that AF susceptibility may be enhanced by either change in KCNA5 function."
reach
"This engineered cell line designated KCNA5 fs/fs hence resembles the genotype of a well documented patient case of lone AF caused by a heterozygous but dominant KCNA5 nonsense mutation, to lead to a loss of K v 1.5 function."
reach
"A gain of KCNA5 function is thought to promote AF through electrical reentry."
KCNA5 inhibits PSMD4.
| 4
KCNA5 inhibits PSMD4. 4 / 4
| 4
reach
"Further, loss-of-function mutation in KCNA5 has been shown to cause AF in humans 8."
reach
"Recent studies however have shown that loss-of-function mutations in KCNA5, the gene that encodes K V 1.5, the alpha subunit of the I Kur channel, is associated with the development of AF and that inhibition of I Kur can promote the induction of AF in experimental models."
reach
"Since both gain and loss-of-function mutations in KCNA5 can cause AF, it may be postulated that this must be based on distinct mechanisms."
reach
"Loss-of-function mutations in the related voltage gated potassium channel KCNA5 unexpectedly lead to AF by an atypical mechanism involving decreased I Kur which leads to a predisposition for atrial action potential prolongation and early after-depolarizations [XREF_BIBR, XREF_BIBR]."
KCNA5 binds PSMD4.
| 2
| 2
sparser
"Indeed, a loss-of-function mutation in KCNA5 associated with AF results in decreased ultrarapid delayed rectifier potassium current ( I Kur ), prolongation of the atrial action potential, and facilitates early afterdepolarizations. xref Recent discoveries have also revealed mechanisms by which mutations in sodium channels may influence AF susceptibility."
sparser
"Important issues regarding the safety of I Kur blockers have been raised recently with the finding that loss-of-function mutations in KCNA5 are associated with familial AF. xref Because KCNA5 encodes the α subunit of the I Kur channel, these results suggest that a reduction in I Kur may predispose to the development of AF."
KCNA5 affects ACTN2
7 2 |
7 2 |
hprd
No evidence text available
biogrid
No evidence text available
biogrid
No evidence text available
biogrid
No evidence text available
biogrid
No evidence text available
hprd
No evidence text available
biogrid
No evidence text available
biogrid
No evidence text available
biogrid
No evidence text available
| 9 8
| 6 5
reach
"Overexpression of human KCNA5 increases IK V and enhances apoptosis."
reach
"The results of flow cytometry and Tunel assay experiments showed that Kv1.5 silencing induced apoptosis significantly, in contrast to several results reported previously [XREF_BIBR]."
reach
"Taken together, these results suggest that Kv1.5 could induce osteosarcoma cell apoptosis through regulation of Bcl-2 family proteins."
reach
"Overexpression of the human KCNA5 gene increases K+ currents (i.e., K+ efflux or loss), accelerates apoptotic volume decrease (AVD), increases caspase-3 activity, and induces apoptosis."
reach
"The objective of this study was to test the hypothesis that overexpression of KCNA5, which encodes a delayed-rectifier voltage gated K+ (Kv) channel, increases K+ currents and enhances apoptosis."
| 3 3
reach
"Silencing Kv1.5 expression in the osteosarcoma cells significantly inhibited the proliferation of osteosarcoma cells, induced cell cycle arrest at G0/G1 phase, and induced cell apoptosis through up-regulation of p21, p27, Bax, Bcl-XL and caspase-3 and down-regulation of cyclins A, cyclins D1, cyclins E, Bcl-2 and Bik."
reach
"Silencing of Kv1.5 Gene Inhibits Proliferation and Induces Apoptosis of Osteosarcoma Cells."
reach
"In contrast, overexpression of KCNA5 gene or attenuation of Kv1.5 downregulation XREF_BIBR, XREF_BIBR, XREF_BIBR reduces apoptosis during these diseases."
KCNA5 affects ACTN1
| 8
| 6
sparser
"These results confirm the interaction between Kv1.5 and α-actinin-2 seen in the yeast two-hybrid growth assay, both in vitro and in HEK cells."
sparser
"To further investigate the binding of Kv1.5 to α-actinin-2, a GST fusion protein affinity binding method was employed."
sparser
"Thus, a significant portion of the interaction between Kv1.5 and α-actinin-2 is mediated across a region where the N-terminus meets the core transmembrane domains of the protein."
sparser
"None yielded lacZ reporter gene activity above control, showing that there is little to no interaction between the C-terminus of Kv1.5 and α-actinin-2."
sparser
"As shown in , neither Ca nor calmodulin had any effect on α-actinin-2 binding to Kv1.5."
sparser
"We utilized the yeast two-hybrid lacZ reporter gene to estimate the relative strength of interaction between various domains in Kv1.5 and the α-actinin-2 interacting fragment."
ACTN1 binds DLG1 and KCNA5. 1 / 1
| 1
sparser
"We found that both Kv1.5 and SAP97 interact strongly with α-actinin2."
| 1
sparser
"Substantial further work will be necessary to identify the precise residues required for Kv1.5 and Kv1.4 binding to α-actinin-2."
5-HT affects KCNA5
| 8
5-HT inhibits KCNA5. 8 / 8
| 8
sparser
"KMUP-1 modulation of 5-HT-inhibited Kv1.5 proteins via the PKC pathway."
sparser
"Notably, KMUP-1 reversed 5-HT-inhibited Kv1.5 protein and this effect was attenuated significantly by adding the PKC activator PMA, suggesting that KMUP-1 did modulate the 5-HT-mediated PKC pathway (Fig xref )."
sparser
"5-HT-inhibited Kv1.5 protein was unaffected by the PKA inhibitor KT5720 but significantly affected by the PKC inhibitor chelerythrine, suggesting that 5-HT is not involved in cross-talk with AC/PKA cascades xref , xref but exclusively involved in the PKC pathway in rat PASMCs."
sparser
"Notably, KMUP-1 reversed 5-HT-inhibited Kv1.5 protein and this response was significantly attenuated by co-incubation with the PKC activator PMA, suggesting that 5-HT-mediated PKC signaling can be modulated by KMUP-1."
sparser
"Taken together, KMUP-1 alone increased Kv1.5 and it also reversed 5-HT-inhibited Kv1.5 protein, suggesting that KMUP-1 is not simply an inhibitor of 5-HT-mediated PKC signaling, but might have the direct actions on AC/PKA pathways."
sparser
"Surprisingly, in addition to increases in Kv1.5 channel protein with KMUP-1, KMUP-1 also reversed 5-HT inhibition of Kv1.5 and this effect was markedly blunted in combination with the PKC activator PMA."
sparser
"Additionally, 5-HT inhibition of Kv1.5, Kv2.1 and BK Ca channel proteins in PASMCs was reversed by KMUP-1 in a dose-dependent manner."
sparser
"5-HT inhibition of Kv1.5 protein was reversed by KMUP-1 (1 μM), chelerythrine (1 μM), KMUP-1+PMA (1 μM) or KMUP-1+chelerythrine, but not affected by the PKC activator PMA (1 μM)."
KCNA5 affects DLG4
5 1 | 1
5 1 |
biogrid
No evidence text available
biogrid
No evidence text available
hprd
No evidence text available
biogrid
No evidence text available
biogrid
No evidence text available
biogrid
No evidence text available
DLG1 binds DLG4 and KCNA5. 1 / 1
| 1
sparser
"PSD-95 and SAP97 interact with Kv1.5 and recruit channels to a complex which includes caveolin-3 ( xref ; xref )."
SRC affects KCNA5
2 1 | 2
2 1 | 2
biogrid
No evidence text available
biogrid
No evidence text available
hprd
No evidence text available
sparser
"Recent work has shown that the Src tyrosine kinase can physically associate with Kv1.5 to bring about its tyrosine kinase–dependent suppression ( Holmes et al. 1996 )."
sparser
"Using immunoprecipitation, we show that Kv1.5 is associated with Src family protein tyrosine kinases and that this association does not change with cell differentiation."
| 5
| 5
reach
"Overexpression of the human KCNA5 gene increases K+ currents (i.e., K+ efflux or loss), accelerates apoptotic volume decrease (AVD), increases caspase-3 activity, and induces apoptosis."
reach
"The objective of this study was to test the hypothesis that overexpression of KCNA5, which encodes a delayed-rectifier voltage gated K+ (Kv) channel, increases K+ currents and enhances apoptosis."
reach
"Furthermore, ST induced apoptotic cell shrinkage was significantly accelerated in COS-7 cells and rat PASMC transfected with KCNA5, and blockade of KCNA5 channels with 4-aminopyridine (4-AP) reduced K+ currents through KCNA5 channels and inhibited ST induced apoptosis in KCNA5 transfected COS-7 cells."
reach
"Kv1.5 mediates the ultrarapid potassium current (I Kur) that controls atrial action potential duration."
reach
"Moreover, voltage dependent potassium channels are also targeted by miRNAs - KCNA5 as a target of miR-1, KCNQ5 as a target of miR-190 and TASK1 as a target of miR-138."
KCNA5 affects SRC
2 1 | 2
2 1 | 2
biogrid
No evidence text available
biogrid
No evidence text available
hprd
No evidence text available
sparser
"Recent work has shown that the Src tyrosine kinase can physically associate with Kv1.5 to bring about its tyrosine kinase–dependent suppression ( Holmes et al. 1996 )."
sparser
"Using immunoprecipitation, we show that Kv1.5 is associated with Src family protein tyrosine kinases and that this association does not change with cell differentiation."
KCNA5 affects FHL1
3 | 1 1
3 | 1
biogrid
No evidence text available
reach
"FHL1 also binds and regulates KCNA5, the key molecular component of the voltage gated K + channel (Kv1.5), responsible for repolarization of the human atrium after depolarization [65] and an important therapeutic target in the treatment of AF [66]."
biogrid
No evidence text available
biogrid
No evidence text available
KCNA5 binds FHL1. 1 / 1
| 1
sparser
"FHL1 also binds and regulates KCNA5, the key molecular component of the voltage-gated K + channel (Kv1.5), responsible for repolarization of the human atrium after depolarization [65] and an important therapeutic target in the treatment of AF [66] ."
CAV1 affects KCNA5
2 | 1 1 1 1
CAV1 binds KCNA5.
2 | 1 1 1
2 | 1 1 1
sparser
"Overall, our finding indicated that KCNA5 protein may interact with Cav-1, thereby contributing to the proliferation and early transformation of mammary cells."
biogrid
No evidence text available
trips
"Overall, our finding indicated that KCNA5 protein may interact with Cav-1, thereby contributing to the proliferation and early transformation of mammary cells."
biogrid
No evidence text available
CAV1 increases the amount of KCNA5.
| 1
CAV1 increases the amount of KCNA5. 1 / 1
| 1
reach
"We found that expression of Cav-1 correlated with the expression of Kv channels in mammary epithelial cells (MCF10A, MCF10A-ST1, and MCF7), and silencing of Cav-1 inhibited the expression of KCNA5 (voltage gated shaker related subfamily A, member 5)."
Polycomb affects KCNA5
| 4
Polycomb inhibits KCNA5. 4 / 4
| 4
reach
"We recently showed that polycomb dependent repression of KCNA5 contributes to Ewing sarcoma cell survival under conditions of hypoxia."
reach
"KCNA5 is repressed by polycomb in cancer cells."
reach
"Thus, we hypothesized that tolerance of hypoxic stress in cancer cells might be mediated by polycomb dependent repression of the KCNA5 locus."
reach
"Our results implicate polycomb dependent epigenetic repression of KCNA5 as a key mechanism of channel inhibition and reveal the critical role of this inhibition in promoting cancer cell survival under conditions of microenvironmental stress, in particular hypoxic stress."
| 2 4
reach
"We explored the effects of Kv1.5 silencing on proliferation and growth of osteosarcoma cells using CCK-8 and colony formation assays, and we found that Kv1.5 silencing significantly suppressed cell proliferation and growth after a 48-h treatment compared to the control-shRNA or untreated groups in MG-63 cells."
reach
"Promoter Methylation Analysis Reveals that KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation."
reach
"Silencing of Kv1.5 Gene Inhibits Proliferation and Induces Apoptosis of Osteosarcoma Cells."
reach
"Silencing Kv1.5 expression in the osteosarcoma cells significantly inhibited the proliferation of osteosarcoma cells, induced cell cycle arrest at G0/G1 phase, and induced cell apoptosis through up-regulation of p21, p27, Bax, Bcl-XL and caspase-3 and down-regulation of cyclins A, cyclins D1, cyclins E, Bcl-2 and Bik."
KCNA5 affects CREB
| 4
| 4
sparser
"We found that CREB knock-down by siRNA reduces Kv1.5, CREB binds to the Kv1.5 promoter in the heart, and CREB increases transcription of mouse and human Kv1.5 promoters."
sparser
"3.3 Chromatin Immunoprecipitation shows that CREB binds to the Kv1.5 promoter in the heart."
sparser
"To determine if CREB binds to the Kv1.5 promoter in the heart, mouse ventricular tissue was homogenized and chromatin immunoprecipitation (ChIP) was performed with an anti-CREB antibody."
sparser
"Although this early work was suggestive, we have gone further by showing that CREB transfection increases the transcription of human and mouse Kv1.5 promoter reporter constructs, and that ChIP demonstrates binding of CREB to the Kv1.5 promoter in mouse heart."
KCNA5 affects CAV1
2 | 1 1 1
2 | 1 1 1
sparser
"Overall, our finding indicated that KCNA5 protein may interact with Cav-1, thereby contributing to the proliferation and early transformation of mammary cells."
biogrid
No evidence text available
trips
"Overall, our finding indicated that KCNA5 protein may interact with Cav-1, thereby contributing to the proliferation and early transformation of mammary cells."
biogrid
No evidence text available
KCNA5 affects ACTN
| 1 4
| 1 4
sparser
"However, in our system, no evidence for a calmodulin or calcium effect on the association of Kv1.5 with actinin could be found."
sparser
"If, for example, actinin binding to Kv1.5 anchors the channel in the cell interior, SAP97 binding to an overlapping site in actinin could free the channel to traffic to the cell surface."
sparser
"Unlike the reported interaction between actinin and the NMDA receptor, calmodulin was found to have no effect on actinin binding to Kv1.5."
sparser
"Unlike the interaction of actinin with the NMDA receptor, the actinin interaction with Kv1.5 is not affected by calcium or calmodulin."
CREB affects KCNA5
| 4
| 4
sparser
"We found that CREB knock-down by siRNA reduces Kv1.5, CREB binds to the Kv1.5 promoter in the heart, and CREB increases transcription of mouse and human Kv1.5 promoters."
sparser
"3.3 Chromatin Immunoprecipitation shows that CREB binds to the Kv1.5 promoter in the heart."
sparser
"To determine if CREB binds to the Kv1.5 promoter in the heart, mouse ventricular tissue was homogenized and chromatin immunoprecipitation (ChIP) was performed with an anti-CREB antibody."
sparser
"Although this early work was suggestive, we have gone further by showing that CREB transfection increases the transcription of human and mouse Kv1.5 promoter reporter constructs, and that ChIP demonstrates binding of CREB to the Kv1.5 promoter in mouse heart."
ACTN affects KCNA5
| 1 4
| 1 4
sparser
"However, in our system, no evidence for a calmodulin or calcium effect on the association of Kv1.5 with actinin could be found."
sparser
"If, for example, actinin binding to Kv1.5 anchors the channel in the cell interior, SAP97 binding to an overlapping site in actinin could free the channel to traffic to the cell surface."
sparser
"Unlike the reported interaction between actinin and the NMDA receptor, calmodulin was found to have no effect on actinin binding to Kv1.5."
sparser
"Unlike the interaction of actinin with the NMDA receptor, the actinin interaction with Kv1.5 is not affected by calcium or calmodulin."
Nickel(2+) affects KCNA5
| 3
| 3
reach
"Fig. 2 shows the concentration response relationship for the block of Kv1.5 by Ni 2+ and the influence of [K +] o thereon."
reach
"Is the block of Kv1.5 by Ni 2+ antagonized by increasing [K +] o?"
reach
"These results clearly demonstrate that, as with the block by H o + and Zn 2+, the block of Kv1.5 by Ni 2+ is antagonized by increasing [K +] o."
UBE2I affects KCNA5
2 | 1 1
2 | 1 1
biogrid
No evidence text available
biogrid
No evidence text available
sparser
"We find that Kv1.5 interacts specifically with the SUMO-conjugating enzyme Ubc9 and is a target for modification by SUMO-1, -2, and -3 in vivo."
MYC affects KCNA5
| 3
MYC binds KCNA5.
| 2
STUB1 binds KCNA5 and MYC. 2 / 2
| 2
sparser
"Interaction with Kv1.5 of myc-CHIP ∆U was much less than that of myc-CHIP WT ( Fig. 5 B), whereas the interaction with Hsc70 remained unaltered ( Fig. 6 A, right panel)."
sparser
"Whereas myc-CHIP WT could form complexes with Kv1.5, myc-CHIP ∆TPR and myc-CHIP ∆U failed to interact with Kv1.5 ( Fig. 5 B)."
MYC ubiquitinates KCNA5.
| 1
MYC ubiquitinates KCNA5. 1 / 1
| 1
sparser
"Co-expression of Hsc70 together with myc-CHIP WT enhanced ubiquitination of Kv1.5 more strongly than expression of CHIP or Hsc70 alone ( Fig. 6 C)."
KCNA5 affects UBE2I
2 | 1 1
2 | 1 1
biogrid
No evidence text available
biogrid
No evidence text available
sparser
"We find that Kv1.5 interacts specifically with the SUMO-conjugating enzyme Ubc9 and is a target for modification by SUMO-1, -2, and -3 in vivo."
KCNA5 affects FYN
1 | 2
1 | 1
sparser
"It has been shown that Kv1.5 associates with the Src kinase Fyn in mammalian hippocampus through Kv1.5's Src homology 3 (SH3) domain [ xref ]."
biogrid
No evidence text available
FYN binds KCNA5 and KCNB1. 1 / 1
| 1
sparser
"The Kv1.5 and Kv2.1 K+-channel alpha subunits are constitutively tyrosine phosphorylated and physically associate with Fyn both in cultured SCs and in the sciatic nerve in vivo."
KCNA5 affects CDH2
| 1 3
| 1 2
sparser
"Kv1.5 associates with N-cadherin [40,61] , caveolin and PSD-95/SAP97 [62–64] , as well as with lipid rafts [65] ."
sparser
"However, hitherto no studies have been published on a functional interaction between N-cadherin and Kv1.5."
CDH2 binds CTTN and KCNA5. 1 / 1
| 1
sparser
"It is known that mXinα interacts not only with cortactin ( xref ) but also with p120-catenin ( xref ) and β-catenin ( xref ), suggesting that mXinα may be required for the association of Kv1.5, cortactin, and N-cadherin."
KCNA5 affects CD244
| 3
| 2
sparser
"Considering all the exposure estimates, expression of TNF-α was associated with both water and urinary concentrations of arsenic, that of POLB was associated with nail and urinary levels, and that of KCNA5 was associated with water and nail levels (and was borderline significant with urinary arsenic)."
sparser
"Furthermore, the expression level of KCNA5 was also associated with nail arsenic concentrations, whereas that of TNF-α was also associated with urine arsenic concentrations."
sparser
"Expression of KCNA5 , which encodes a potassium ion channel protein, was positively associated with water and toe nail arsenic levels."
FYN affects KCNA5
1 | 2
1 | 1
sparser
"It has been shown that Kv1.5 associates with the Src kinase Fyn in mammalian hippocampus through Kv1.5's Src homology 3 (SH3) domain [ xref ]."
biogrid
No evidence text available
FYN binds KCNA5 and KCNB1. 1 / 1
| 1
sparser
"The Kv1.5 and Kv2.1 K+-channel alpha subunits are constitutively tyrosine phosphorylated and physically associate with Fyn both in cultured SCs and in the sciatic nerve in vivo."
CDH2 affects KCNA5
| 1 3
| 1 2
sparser
"Kv1.5 associates with N-cadherin [40,61] , caveolin and PSD-95/SAP97 [62–64] , as well as with lipid rafts [65] ."
sparser
"However, hitherto no studies have been published on a functional interaction between N-cadherin and Kv1.5."
CDH2 binds CTTN and KCNA5. 1 / 1
| 1
sparser
"It is known that mXinα interacts not only with cortactin ( xref ) but also with p120-catenin ( xref ) and β-catenin ( xref ), suggesting that mXinα may be required for the association of Kv1.5, cortactin, and N-cadherin."
CD244 affects KCNA5
| 3
| 2
sparser
"Considering all the exposure estimates, expression of TNF-α was associated with both water and urinary concentrations of arsenic, that of POLB was associated with nail and urinary levels, and that of KCNA5 was associated with water and nail levels (and was borderline significant with urinary arsenic)."
sparser
"Furthermore, the expression level of KCNA5 was also associated with nail arsenic concentrations, whereas that of TNF-α was also associated with urine arsenic concentrations."
sparser
"Expression of KCNA5 , which encodes a potassium ion channel protein, was positively associated with water and toe nail arsenic levels."
BMI1 affects KCNA5
| 1 2
BMI1 inhibits KCNA5.
| 2
BMI1 inhibits KCNA5. 2 / 2
| 2
reach
"In addition, levels of KCNA5 expression were found to be higher in a subset of ES tumors that did not express high levels of BMI-1, thus providing indirect evidence that BMI-1 might repress KCNA5 in ES (XREF_FIG)."
reach
"Thus, BMI-1 dependent repression of the KCNA5 gene can be an adaptive, physiologic response to chronic stress."
BMI1 binds KCNA5.
| 1
| 1
sparser
"ChIP assays with antibodies against SCMH1 or BMI1 indicated that both SCMH1 and BMI1 bound to the promoter regions of Kcna5 and Kcnab2 ( xref )."
| 2
| 2
reach
"As expected, increasing sulfenic acid with tBOOH, or trapping this modification with dimedone, significantly increased internalization of Kv1.5 (XREF_FIG)."
reach
"Therefore, under acute oxidative stress, sulfenic acid modification triggers internalization of Kv1.5 and significantly reduces channel recycling back to the cell surface."
LpxD affects KCNA5
| 2
| 1
sparser
"In the previously mentioned study, the association of KCNA5 with SSc and specifically with PAH-positive (PAH + ) patients was described [ xref ]."
KCNA5 binds PAH and lpxD. 1 / 1
| 1
sparser
"In light of the previous evidence, the main goal of this report is to replicate the association of KCNA5 rs10744676 polymorphism with SSc and SSc-related PAH in an independent European population of Caucasian ancestry."
Cyclic AMP affects KCNA5
2 |
Cyclic AMP increases the amount of KCNA5. 2 / 2
2 |
bel
"# Ariadne: The transcription of a potassium channel gene, Kv1.5 , is regulated by glucocorticoids and cAMP in both GH3 cells and cardiac myocytes ( 16-18 ). [Expression]"
bel
"A cAMP response element (CRE) consensus signal was identified in the 5'-noncoding region. cAMP regulates the expression of Kv1.5 gene in a cell-specific manner. In primary cardiac cells, cAMP induces a 6-fold increase in the steady state levels of Kv1.5 transcript. However, in GH3 cells cAMP induces a 5-6-fold decrease in steady state levels of Kv1.5 transcript."
TNK2 affects KCNA5
2 |
2 |
biogrid
No evidence text available
biogrid
No evidence text available
SIRT1 affects KCNA5
2 |
2 |
biogrid
No evidence text available
biogrid
No evidence text available
RACK1 affects KCNA5
2 |
2 |
biogrid
No evidence text available
biogrid
No evidence text available
RAB5A affects KCNA5
1 | 1
1 |
biogrid
No evidence text available
| 1
sparser
"Upon internalization, Kv1.5 rapidly associated with Rab5-and Rab4-positive endosomes, suggesting that the channel is internalized via a Rab5-dependent pathway and rapidly targeted for recycling to the plasma membrane."
RAB4A affects KCNA5
1 | 1
1 |
biogrid
No evidence text available
| 1
sparser
"Upon internalization, Kv1.5 rapidly associated with Rab5-and Rab4-positive endosomes, suggesting that the channel is internalized via a Rab5-dependent pathway and rapidly targeted for recycling to the plasma membrane."
PTPRE affects KCNA5
2 |
2 |
hprd
No evidence text available
hprd
No evidence text available
PSMD4 affects KCNA5
| 2
| 2
sparser
"Indeed, a loss-of-function mutation in KCNA5 associated with AF results in decreased ultrarapid delayed rectifier potassium current ( I Kur ), prolongation of the atrial action potential, and facilitates early afterdepolarizations. xref Recent discoveries have also revealed mechanisms by which mutations in sodium channels may influence AF susceptibility."
sparser
"Important issues regarding the safety of I Kur blockers have been raised recently with the finding that loss-of-function mutations in KCNA5 are associated with familial AF. xref Because KCNA5 encodes the α subunit of the I Kur channel, these results suggest that a reduction in I Kur may predispose to the development of AF."
Notch affects KCNA5
| 2
Notch inhibits KCNA5. 2 / 2
| 2
reach
"Furthermore, activation of Notch attenuates whole-cell K + currents in KCNA5- and KCNA2 transfected cells."
reach
"Furthermore, activation of Notch attenuates whole-cell K + currents in KCNA5- and KCNA2 transfected cells."
NR2F2 affects KCNA5
| 1 1
| 1
reach
"In accordance, we had shown in differentiated hESC-AMs that COUP-TFII is able to bind to the promoters of atrial specific ion channel genes KCNA5 and KCNJ3 and regulates their expression in hESC derived CMs."
sparser
"In accordance, we had shown in differentiated hESC-AMs that COUP-TFII is able to bind to the promoters of atrial-specific ion channel genes KCNA5 and KCNJ3 and regulates their expression in hESC-derived CMs ( xref )."
NOS3 affects KCNA5
| 1 1
| 1 1
reach
"The correlation of polymorphisms with NO level also suggest of an interaction between KCNA5 and NOS3."
sparser
"The correlation of polymorphisms with NO level also suggest of an interaction between KCNA5 and NOS3."
KCNA5 affects lpxD
| 2
| 1
sparser
"In the previously mentioned study, the association of KCNA5 with SSc and specifically with PAH-positive (PAH + ) patients was described [ xref ]."
KCNA5 binds PAH and lpxD. 1 / 1
| 1
sparser
"In light of the previous evidence, the main goal of this report is to replicate the association of KCNA5 rs10744676 polymorphism with SSc and SSc-related PAH in an independent European population of Caucasian ancestry."
KCNA5 affects TNK2
2 |
2 |
biogrid
No evidence text available
biogrid
No evidence text available
KCNA5 affects SIRT1
2 |
2 |
biogrid
No evidence text available
biogrid
No evidence text available
KCNA5 affects RACK1
2 |
2 |
biogrid
No evidence text available
biogrid
No evidence text available
KCNA5 affects RAB5A
1 | 1
1 |
biogrid
No evidence text available
| 1
sparser
"Upon internalization, Kv1.5 rapidly associated with Rab5-and Rab4-positive endosomes, suggesting that the channel is internalized via a Rab5-dependent pathway and rapidly targeted for recycling to the plasma membrane."
KCNA5 affects RAB4A
1 | 1
1 |
biogrid
No evidence text available
| 1
sparser
"Upon internalization, Kv1.5 rapidly associated with Rab5-and Rab4-positive endosomes, suggesting that the channel is internalized via a Rab5-dependent pathway and rapidly targeted for recycling to the plasma membrane."
KCNA5 affects PTPRE
2 |
2 |
hprd
No evidence text available
hprd
No evidence text available
KCNA5 affects NR2F2
| 1 1
| 1
reach
"In accordance, we had shown in differentiated hESC-AMs that COUP-TFII is able to bind to the promoters of atrial specific ion channel genes KCNA5 and KCNJ3 and regulates their expression in hESC derived CMs."
sparser
"In accordance, we had shown in differentiated hESC-AMs that COUP-TFII is able to bind to the promoters of atrial-specific ion channel genes KCNA5 and KCNJ3 and regulates their expression in hESC-derived CMs ( xref )."
KCNA5 affects NOS3
| 1 1
| 1 1
reach
"The correlation of polymorphisms with NO level also suggest of an interaction between KCNA5 and NOS3."
sparser
"The correlation of polymorphisms with NO level also suggest of an interaction between KCNA5 and NOS3."
KCNA5 affects MYC, and STUB1
| 2
STUB1 binds KCNA5 and MYC. 2 / 2
| 2
sparser
"Interaction with Kv1.5 of myc-CHIP ∆U was much less than that of myc-CHIP WT ( Fig. 5 B), whereas the interaction with Hsc70 remained unaltered ( Fig. 6 A, right panel)."
sparser
"Whereas myc-CHIP WT could form complexes with Kv1.5, myc-CHIP ∆TPR and myc-CHIP ∆U failed to interact with Kv1.5 ( Fig. 5 B)."
KCNA5 affects HSPA8
1 | 1
1 |
biogrid
No evidence text available
| 1
sparser
"Hsc70 formed complexes with CHIP and Kv1.5 proteins ( Fig. 6 A , left panel)."
KCNA5 affects GJA1
| 2
| 1
sparser
"In atrial muscle, Kv1.5 labeling was closely associated with labeling of Cx43 (gap junction protein) and DPI/II (desmosomal protein), whereas in SA node Kv1.5 labeling was closely associated with labeling of DPI/II but not labeling of Cx43 (absent in the SA node) or Cx45 (another gap junction protein present in the SA node)."
GJA1 binds GJC1 and KCNA5. 1 / 1
| 1
sparser
"In atrial muscle, Kv1.5 labeling was closely associated with labeling of Cx43 (gap junction protein) and DPI/II (desmosomal protein), whereas in SA node Kv1.5 labeling was closely associated with labeling of DPI/II but not labeling of Cx43 (absent in the SA node) or Cx45 (another gap junction protein present in the SA node)."
KCNA5 affects CTTN
| 2
| 1
sparser
"In addition to showing the association of Kv1.5 with cortactin, Radice group used cardiac-specific N- cadherin conditional knockout mice to provide strong evidence for essential roles of N- cadherin in ICD integrity, cardiac conduction & rhythms, and I k,slow1 surface expression [ xref , xref – xref ]."
CDH2 binds CTTN and KCNA5. 1 / 1
| 1
sparser
"It is known that mXinα interacts not only with cortactin ( xref ) but also with p120-catenin ( xref ) and β-catenin ( xref ), suggesting that mXinα may be required for the association of Kv1.5, cortactin, and N-cadherin."
KCNA5 affects CASP3
| 2 2
KCNA5 activates CASP3. 2 / 2
| 2 2
reach
"It has been reported that overexpression of the KCNA5 gene induces accelerated K efflux and increases caspase-3 proteolytic activity, promoting apoptosis [XREF_BIBR]."
reach
"Overexpression of the human KCNA5 gene increases K+ currents (i.e., K+ efflux or loss), accelerates apoptotic volume decrease (AVD), increases caspase-3 activity, and induces apoptosis."
HSPA8 affects KCNA5
1 | 1
1 |
biogrid
No evidence text available
| 1
sparser
"Hsc70 formed complexes with CHIP and Kv1.5 proteins ( Fig. 6 A , left panel)."
GJA1 affects KCNA5
| 2
| 1
sparser
"In atrial muscle, Kv1.5 labeling was closely associated with labeling of Cx43 (gap junction protein) and DPI/II (desmosomal protein), whereas in SA node Kv1.5 labeling was closely associated with labeling of DPI/II but not labeling of Cx43 (absent in the SA node) or Cx45 (another gap junction protein present in the SA node)."
GJA1 binds GJC1 and KCNA5. 1 / 1
| 1
sparser
"In atrial muscle, Kv1.5 labeling was closely associated with labeling of Cx43 (gap junction protein) and DPI/II (desmosomal protein), whereas in SA node Kv1.5 labeling was closely associated with labeling of DPI/II but not labeling of Cx43 (absent in the SA node) or Cx45 (another gap junction protein present in the SA node)."
GIP affects KCNA5
| 2
GIP phosphorylates KCNA5.
| 1
GIP phosphorylates KCNA5. 1 / 1
| 1
sparser
"Both GIP and GLP-1 increased phosphorylation and acetylation of Kv1.5 and its Kvβ2 protein subunit, leading to their enhanced interaction."
GIP acetylates KCNA5.
| 1
GIP acetylates KCNA5. 1 / 1
| 1
sparser
"Both GIP and GLP-1 increased phosphorylation and acetylation of Kv1.5 and its Kvβ2 protein subunit, leading to their enhanced interaction."
GCG affects KCNA5
| 2
GCG phosphorylates KCNA5.
| 1
GCG phosphorylates KCNA5. 1 / 1
| 1
sparser
"Both GIP and GLP-1 increased phosphorylation and acetylation of Kv1.5 and its Kvβ2 protein subunit, leading to their enhanced interaction."
GCG acetylates KCNA5.
| 1
GCG acetylates KCNA5. 1 / 1
| 1
sparser
"Both GIP and GLP-1 increased phosphorylation and acetylation of Kv1.5 and its Kvβ2 protein subunit, leading to their enhanced interaction."
CTTN affects KCNA5
| 2
| 1
sparser
"In addition to showing the association of Kv1.5 with cortactin, Radice group used cardiac-specific N- cadherin conditional knockout mice to provide strong evidence for essential roles of N- cadherin in ICD integrity, cardiac conduction & rhythms, and I k,slow1 surface expression [ xref , xref – xref ]."
CDH2 binds CTTN and KCNA5. 1 / 1
| 1
sparser
"It is known that mXinα interacts not only with cortactin ( xref ) but also with p120-catenin ( xref ) and β-catenin ( xref ), suggesting that mXinα may be required for the association of Kv1.5, cortactin, and N-cadherin."
| 2
reach
"Current research indicates that Kv1.5, similar to Kv1.3, is inhibited by 4-AP, TEA, and some new chemicals, such as S0100176 (from Sanofi-Aventis) or diphenyl phosphine oxide-1 (DPO-1) 2."
reach
"We first demonstrated that I KCNQ1 was insensitive to concentrations of 4-AP known to inhibit I KCNA5 XREF_BIBR (XREF_FIG)."
~ 50% decrease in I Kur affects KCNA5
| 1
~ 50% decrease in I Kur inhibits KCNA5. 1 / 1
| 1
reach
"Therefore, the ~ 50% decrease in I Kur and Kv1.5 protein levels in AF may reflect a combination of decreased cell surface trafficking and enhanced endocytosis of Kv1.5 leading to channel degradation."
Zinc atom affects KCNA5
| 1
| 1
reach
"As noted above, Zn 2+ also causes a concentration and K o + -dependent inhibition of Kv1.5 currents and for that reason its effects on inactivation were also examined."
Phosphane affects KCNA5
| 1
| 1
reach
"Current research indicates that Kv1.5, similar to Kv1.3, is inhibited by 4-AP, TEA, and some new chemicals, such as S0100176 (from Sanofi-Aventis) or diphenyl phosphine oxide-1 (DPO-1) 2."
Perhexiline affects KCNA5
| 1
| 1
sparser
"With the use of inside-out macropatches, we found that perhexiline inhibited Kv1.5 current in a time- and voltage-dependent manner with an IC50 value of 1.5 x 10(-6) M at +50 mV."
| 1 1
reach
"Sp1 has known sensitivity to oxidative stress and, consistent with this property, Kcna5 promoter activity was suppressed by hydrogen peroxide induced oxidative stress."
1 |
Transcriptionally active hsa-miR-766-5p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-7106-5p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-6883-5p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-6797-5p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-6785-5p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-6730-5p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-6133 decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-6130 decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-6129 decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-6127 decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-5681a decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-488-3p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-4756-5p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-4739 decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-4728-5p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-4510 decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-4433b-3p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-4419a decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-26b-5p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-149-3p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-1321 decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-1249-5p decreases the amount of KCNA5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Glucocorticoid increases the amount of KCNA5. 1 / 1
1 |
bel
"# Ariadne: The transcription of a potassium channel gene, Kv1.5 , is regulated by glucocorticoids and cAMP in both GH3 cells and cardiac myocytes ( 16-18 ). [Expression]"
| 1
| 1
reach
"In 1 mM Cd 2+ the V 1/2 for the g-V relationship was shifted rightward by 19.5 +/- 1.2 mV.Of the divalent cations we tested for an ability to block Kv1.5, Mn 2+ proved to be the least effective."
YIPF4 affects KCNA5
1 |
1 |
biogrid
No evidence text available
| 1
sparser
"Finally, we find that the induction of Kv1.5 protein is associated with an increase in a noninactivating component of the voltage-gated K+ current."
VANGL2 affects KCNA5
1 |
1 |
biogrid
No evidence text available
V-SRC affects KCNA5
| 1
V-SRC inhibits KCNA5. 1 / 1
| 1
reach
"The Src-TK inhibitor PP2 prevented KCNA5 current suppression by v-Src."
TMX2 affects KCNA5
1 |
1 |
biogrid
No evidence text available
TMEM223 affects KCNA5
1 |
1 |
biogrid
No evidence text available
TFRC affects KCNA5
1 |
1 |
biogrid
No evidence text available
TEA affects KCNA5
| 1
TEA inhibits KCNA5. 1 / 1
| 1
reach
"Current research indicates that Kv1.5, similar to Kv1.3, is inhibited by 4-AP, TEA, and some new chemicals, such as S0100176 (from Sanofi-Aventis) or diphenyl phosphine oxide-1 (DPO-1) 2."
SNTA1 affects KCNA5
1 |
1 |
biogrid
No evidence text available
SLC9A3R2 affects KCNA5
| 1
| 1
sparser
"Expression studies in Xenopus oocytes demonstrated that NHERF1 and NHERF2 activate Kv1.5, an effect requiring the C-terminal PDZ-binding motif on Kv1.5."
SLC9A3R1 affects KCNA5
| 1
| 1
sparser
"Expression studies in Xenopus oocytes demonstrated that NHERF1 and NHERF2 activate Kv1.5, an effect requiring the C-terminal PDZ-binding motif on Kv1.5."
SLC30A6 affects KCNA5
1 |
1 |
biogrid
No evidence text available
SLC27A6 affects KCNA5
1 |
1 |
biogrid
No evidence text available
SENP2 affects KCNA5
| 1
SENP2 desumoylates KCNA5. 1 / 1
| 1
sparser
"Benson et al have reported that SENP2 can de-SUMOylate Kv1.5 and lead to a substantial hyperpolarizing shift in the voltage dependence of steady-state inactivation( xref )."
SARAF affects KCNA5
1 |
1 |
biogrid
No evidence text available
RHBDD3 affects KCNA5
1 |
1 |
biogrid
No evidence text available
Polycomb affects KCNA5
| 1 1
Polycomb inhibits KCNA5. 1 / 1
| 1 1
reach
"Polycomb dependent repression of the potassium channel encoding gene KCNA5 promotes cancer cell survival under conditions of stress."
PRKCQ affects KCNA5
1 |
1 |
biogrid
No evidence text available
PRKCB affects KCNA5
1 |
1 |
biogrid
No evidence text available
PRKCA affects KCNA5
1 |
PRKCA phosphorylates KCNA5 on T15. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKAA1 affects KCNA5
| 1
PRKAA1 inhibits KCNA5. 1 / 1
| 1
sparser
"Inhibition of mitochondrial oxidative phosphorylation with either phenformin or hypoxia was found to result in AMP-activated protein kinase (AMPK)-mediated inhibition of Kv1.5 channels in rat PASMCs."
PPP2 affects KCNA5
| 1
PPP2 activates KCNA5. 1 / 1
| 1
reach
"The Src-TK inhibitor PP2 prevented KCNA5 current suppression by v-Src."
P90RSK affects KCNA5
| 1
P90RSK inhibits KCNA5. 1 / 1
| 1
sparser
"P90RSK Inhibits Kv4.3- and Kv1.5- rather than Kv4.2- and Kv2.1-encoded Channel Activities."
OLR1 affects KCNA5
| 1
| 1
sparser
"Hence, it is possible that Ang II- or oxLDL-induced increase in Kv1.5 may interact with TGF-β/SMAD signaling pathway, especial with SMAD4, which can reduce UCP2 expression, enhance mitochondrial ROS production and promote endothelial injury."
NT5C3A affects KCNA5
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1 |
biogrid
No evidence text available
NPHP3 affects KCNA5
| 1
| 1
sparser
"A nonsense mutation in the pore domain (E375X) and three missense mutations in the C-terminal region of KCNA5 (T527M, A576V, E610K) are associated with autosomal dominant atrial fibrillation susceptibility type 7 (ATFB7; xref )."
NPHP1 affects KCNA5
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1 |
biogrid
No evidence text available
NOG affects KCNA5
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Transcriptionally active NOG decreases the amount of KCNA5. 1 / 1
1 |
biopax:ctd
No evidence text available
NH affects KCNA5
| 1
KCNA5 binds NH. 1 / 1
| 1
sparser
"In this study, we have characterized the gating properties of the short NH 2 -terminal form of human Kv1.5."
| 1
reach
"Additionally, our results predict that deterioration of the actin cytoskeleton would disrupt myosin mediated delivery of Kv1.5 to the plasma membrane."
LEMD2 affects KCNA5
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1 |
biogrid
No evidence text available
Kvbeta2.1 subunit affects KCNA5
| 1
Kvbeta2.1 subunit inhibits KCNA5. 1 / 1
| 1
reach
"In fact, the presence of the Kvbeta2.1 subunit impairs the location of Kv1.5 in rafts, and this has been proposed to be the mechanism of how Kv1.5 colocalizes with caveolin in heterologous expression systems that lack Kvbeta expression but does not in native cells and tissues."
Kv1.5 mutant channels affects KCNA5
| 1
Kv1.5 mutant channels activates KCNA5. 1 / 1
| 1
reach
"A consistent pattern that emerges from these studies, whether it is the spontaneously occurring conductance collapse in Shaker IR and Kv1.5 mutant channels or the metal ion induced block and conductance collapse in wt Kv1.5, is that inhibition of the conductance loss occurs with low millimolar K o + concentrations and that this inhibition occurs in the absence of a change of the inactivation rate measured during depolarizing pulses."
KN-93 affects KCNA5
| 1
KN-93 inhibits KCNA5. 1 / 1
| 1
sparser
"MDR1 did not affect KCNA5 inhibition by KN-93 (1 µM), a blocker acting on the outer mouth of the channel pore."
KCNA5 affects uncoupling protein 2
| 1
KCNA5 increases the amount of uncoupling protein 2. 1 / 1
| 1
reach
"In oxLDL induced endothelial cell injury model, we further found that knockdown of KCNA5 gene attenuated, whereas overexpression of KCNA5 gene enhanced oxLDL induced endothelial morphological changes, ROS generation derived from NADPH oxidase and mitochondria, and the protein expression of uncoupling protein 2 (UCP2), a modulator of mitochondria derived ROS production XREF_BIBR, XREF_BIBR."
| 1
| 1
reach
"Diamide treatment produced a robust, global increase in sulfenic acid modified proteins in the heart (XREF_SUPPLEMENTARY), and importantly, increased sulfenic acid modification to Kv1.5 (XREF_FIG)."
KCNA5 affects pyraclofos
| 1
| 1
reach
"Moreover, voltage dependent potassium channels are also targeted by miRNAs - KCNA5 as a target of miR-1, KCNQ5 as a target of miR-190 and TASK1 as a target of miR-138."
KCNA5 affects nickel(2+)
| 1
KCNA5-H463Q inhibits nickel(2+). 1 / 1
| 1
reach
"Currents through the Kv1.5 H463Q construct decreased by ~ 30% in 5 mM Ni 2+ and, as with the Zn 2+ block of this mutant channel (Kehl et al., 2002), the n H fitted to the concentration dependence of this block was quite small (~ 0.5) suggesting the involvement of a binding site and mechanism of action that is different."
KCNA5 affects cell death
| 1 1
| 1 1
reach
"Further, this disruption of Kv1.5 trafficking was shown to cause arrhythmias and sudden-arrhythmic death in mice."
KCNA5 affects cell cycle
| 1
| 1
reach
"Silencing Kv1.5 expression in the osteosarcoma cells significantly inhibited the proliferation of osteosarcoma cells, induced cell cycle arrest at G0/G1 phase, and induced cell apoptosis through up-regulation of p21, p27, Bax, Bcl-XL and caspase-3 and down-regulation of cyclins A, cyclins D1, cyclins E, Bcl-2 and Bik."
KCNA5 affects YIPF4
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1 |
biogrid
No evidence text available
| 1
sparser
"Finally, we find that the induction of Kv1.5 protein is associated with an increase in a noninactivating component of the voltage-gated K+ current."
KCNA5 affects VANGL2
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1 |
biogrid
No evidence text available
KCNA5 affects TMX2
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1 |
biogrid
No evidence text available
KCNA5 affects TMEM223
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1 |
biogrid
No evidence text available
KCNA5 affects TFRC
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1 |
biogrid
No evidence text available
KCNA5 affects SNTA1
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1 |
biogrid
No evidence text available
KCNA5 affects SLC8A1
| 1
KCNA5 inhibits SLC8A1. 1 / 1
| 1
reach
"Neither stimulus affected Kcna5, Kcnma1, Kcnn4, and Trpm2 but both decreased Slc8a1."
KCNA5 affects SLC30A6
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1 |
biogrid
No evidence text available
KCNA5 affects SLC27A6
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1 |
biogrid
No evidence text available
KCNA5 affects SCN5A, and ion channel
| 1
sparser
"The XIRP proteins interact with cardiac ion channel proteins Nav1.5 and Kv1.5 within intercalated 8 ."
| DOI
KCNA5 affects SARAF
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1 |
biogrid
No evidence text available
KCNA5 affects RHBDD3
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1 |
biogrid
No evidence text available
KCNA5 affects RAB4A, and RAB5A
| 1
| 1
sparser
"Upon internalization, Kv1.5 rapidly associated with Rab5-and Rab4-positive endosomes, suggesting that the channel is internalized via a Rab5-dependent pathway and rapidly targeted for recycling to the plasma membrane."
KCNA5 affects PRKCQ
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1 |
biogrid
No evidence text available
KCNA5 affects PRKCB
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1 |
biogrid
No evidence text available
KCNA5 affects PAH, and lpxD
| 1
KCNA5 binds PAH and lpxD. 1 / 1
| 1
sparser
"In light of the previous evidence, the main goal of this report is to replicate the association of KCNA5 rs10744676 polymorphism with SSc and SSc-related PAH in an independent European population of Caucasian ancestry."
KCNA5 affects OLR1
| 1
| 1
sparser
"Hence, it is possible that Ang II- or oxLDL-induced increase in Kv1.5 may interact with TGF-β/SMAD signaling pathway, especial with SMAD4, which can reduce UCP2 expression, enhance mitochondrial ROS production and promote endothelial injury."
KCNA5 affects NT5C3A
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1 |
biogrid
No evidence text available
KCNA5 affects NPHP3
| 1
| 1
sparser
"A nonsense mutation in the pore domain (E375X) and three missense mutations in the C-terminal region of KCNA5 (T527M, A576V, E610K) are associated with autosomal dominant atrial fibrillation susceptibility type 7 (ATFB7; xref )."
KCNA5 affects NPHP1
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1 |
biogrid
No evidence text available
KCNA5 affects NLRP1, and PAH
| 1
NLRP1 binds KCNA5 and PAH. 1 / 1
| 1
sparser
"This, however, yielded positive and negative results, with on one hand associations of NLRP1 and KCNA5 with PAH, and on the other hand no associations with fibrosis-related MMP genes."
KCNA5 affects NH
| 1
KCNA5 binds NH. 1 / 1
| 1
sparser
"In this study, we have characterized the gating properties of the short NH 2 -terminal form of human Kv1.5."
KCNA5 affects NFAT
| 1
KCNA5 inhibits NFAT. 1 / 1
| 1
sparser
"Kv1.5 inhibits the calcium-dependent transcription factor NFAT, which impairs apoptosis."
KCNA5 affects NAV1, and XIRP2
| 1
XIRP2 binds NAV1 and KCNA5. 1 / 1
| 1
sparser
"On the other hand, the epitopes recognized by U1040 are located at the extreme C‐terminus of Xirp2, which may not be required for Xirp2 to interact with Kv1.5 and Nav1.5."
KCNA5 affects Lys-Val
| 1
KCNA5 activates Lys-Val. 1 / 1
| 1
reach
"Overexpression of the human KCNA5 gene in rat PASMC and other cell types increases whole-cell Kv currents and causes membrane hyperpolarization."
KCNA5 affects LEMD2
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1 |
biogrid
No evidence text available
KCNA5 affects KCNJ3, NR2F2, and ion channel
| 1
sparser
"In accordance, we had shown in differentiated hESC-AMs that COUP-TFII is able to bind to the promoters of atrial-specific ion channel genes KCNA5 and KCNJ3 and regulates their expression in hESC-derived CMs ( xref )."
| 1
sparser
"We then determined whether PcG proteins interacted with the promoter region of Kcna5 or Kcnab2 and whether changes in PcG protein abundance can result in alteration of outward potassium currents."
KCNA5 affects Ischemia
| 1
sparser
"It was recently shown that exposure of neuronal cells to acute hypoxia and glucose deprivation leads to apoptosis and that this ischemia-induced cell death is associated with up-regulation of Kv1.5 expression ( xref )."
KCNA5 affects IK
| 1
KCNA5 activates IK. 1 / 1
| 1
reach
"Overexpression of human KCNA5 increases IK V and enhances apoptosis."
KCNA5 affects HTR2A
| 1
KCNA5 inhibits HTR2A. 1 / 1
| 1
sparser
"If MK801 and ketamine inhibit Kv1.5, these drugs could be hypothesized to augment 5-HT 2A R signaling by facilitating 5-HT 2A R-mediated Kv1.5 inhibition and E m depolarization."
KCNA5 affects HSP90AA1
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biogrid
No evidence text available
KCNA5 affects GST
| 1
| 1
sparser
"Confirming yeast two-hybrid studies, data in show that α-actinin-2 did not bind to the Kv1.5 C-terminus GST fusion protein."
KCNA5 affects GOLM1
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1 |
biogrid
No evidence text available
KCNA5 affects GJA5
| 1
KCNA5 increases the amount of GJA5. 1 / 1
| 1
reach
"Similarly, silencing of KCNA5 suppressed the expression of Cx40."
KCNA5 affects GHDC
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1 |
biogrid
No evidence text available
KCNA5 affects G0/G1
| 1
KCNA5 activates G0/G1. 1 / 1
| 1
reach
"These results indicated that Kv1.5 silencing induced G0/G1 arrest in osteosarcoma cells through a mechanism involving the up-regulation of cdk inhibitors p21 and p27."
KCNA5 affects FlaG
| 1
| 1
sparser
"The interaction between Kv1.5-FLAG and CHIP was further demonstrated by 72.7% colocalization in the immunofluorescence experiment (supplementary Fig. 1)."
KCNA5 affects ERBIN
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1 |
biogrid
No evidence text available
KCNA5 affects DYNC1I1
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1 |
biogrid
No evidence text available
KCNA5 affects DOLK
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1 |
biogrid
No evidence text available
KCNA5 affects DNALI1
| 1
| 1
sparser
"Coimmunoprecipitation experiments demonstrated a direct interaction between Kv1.5 and the dynein motor complex in both heterologous cells and rat cardiac myocytes, supporting the role of this complex in Kv1.5 trafficking, which required an intact SH3-binding domain in the Kv1.5 N terminus to occur."
KCNA5 affects DNAJC18
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1 |
biogrid
No evidence text available
KCNA5 affects DEFB1
| 1
| 1
sparser
"We have delineated a Kv1.5 aminoterminal region of up to 90 amino acids (residues 112-201) that is sufficient for interactions of Kv1.5 alpha and Kv beta 1 subunits."
KCNA5 affects DCTN2
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1 |
biogrid
No evidence text available
| 1 1
| 1 1
reach
"Polycomb dependent repression of the potassium channel encoding gene KCNA5 promotes cancer cell survival under conditions of stress."
KCNA5 affects CYB5R1
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1 |
biogrid
No evidence text available
KCNA5 affects COUP-TFs
| 1
KCNA5 activates COUP-TFs. 1 / 1
| 1
reach
"To test whether the atrial enriched ion channel genes KCNA5 and KCNJ3 are direct targets of COUP-TFs, we performed ChIP-qPCR assays using day 30 hESC-atrial CMs."
KCNA5 affects C1orf43
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1 |
biogrid
No evidence text available
KCNA5 affects C17orf80
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biogrid
No evidence text available
KCNA5 affects ATP2B4
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1 |
biogrid
No evidence text available
KCNA5 affects ATP2A3
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1 |
biogrid
No evidence text available
KCNA5 affects ANKLE2
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1 |
biogrid
No evidence text available
KCNA5 affects ADCY3
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1 |
biogrid
No evidence text available
KCNA5 affects ADCK2
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1 |
biogrid
No evidence text available
KCNA5 affects ABCD4
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1 |
biogrid
No evidence text available
KCNA5 affects ABCB10
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1 |
biogrid
No evidence text available
Ischemia affects KCNA5
| 1
sparser
"It was recently shown that exposure of neuronal cells to acute hypoxia and glucose deprivation leads to apoptosis and that this ischemia-induced cell death is associated with up-regulation of Kv1.5 expression ( xref )."
IL4 affects KCNA5
| 1
IL4 inhibits KCNA5. 1 / 1
| 1
reach
"IL-4 also decreased Kcna3, Kcna5, Kcnn4, and Trpm4 (after I+T)."
IGF1 affects KCNA5
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IGF1 increases the amount of KCNA5. 1 / 1
1 |
bel
"In contrast to PE, a 48% enhancement of the protein expression of Kv1.5 channel was induced by IGF-1 and this stimulation was specifically blocked by genistein."
HSPA8 affects KCNA5, and STUB1
| 1
| 1
sparser
"Hsc70 formed complexes with CHIP and Kv1.5 proteins ( Fig. 6 A , left panel)."
HSP90AA1 affects KCNA5
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biogrid
No evidence text available
GST affects KCNA5
| 1
| 1
sparser
"Confirming yeast two-hybrid studies, data in show that α-actinin-2 did not bind to the Kv1.5 C-terminus GST fusion protein."
GOLM1 affects KCNA5
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1 |
biogrid
No evidence text available
GJA5 affects KCNA5
| 1
GJA5 decreases the amount of KCNA5. 1 / 1
| 1
reach
"In atrial myocytes, downregulation of Cx40 inhibited the expression of KCNA5."
GJA1 affects GJC1, and KCNA5
| 1
GJA1 binds GJC1 and KCNA5. 1 / 1
| 1
sparser
"In atrial muscle, Kv1.5 labeling was closely associated with labeling of Cx43 (gap junction protein) and DPI/II (desmosomal protein), whereas in SA node Kv1.5 labeling was closely associated with labeling of DPI/II but not labeling of Cx43 (absent in the SA node) or Cx45 (another gap junction protein present in the SA node)."
GHDC affects KCNA5
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1 |
biogrid
No evidence text available
FlaG affects KCNA5
| 1
| 1
sparser
"The interaction between Kv1.5-FLAG and CHIP was further demonstrated by 72.7% colocalization in the immunofluorescence experiment (supplementary Fig. 1)."
FYN affects KCNA5, and KCNB1
| 1
FYN binds KCNA5 and KCNB1. 1 / 1
| 1
sparser
"The Kv1.5 and Kv2.1 K+-channel alpha subunits are constitutively tyrosine phosphorylated and physically associate with Fyn both in cultured SCs and in the sciatic nerve in vivo."
ERBIN affects KCNA5
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1 |
biogrid
No evidence text available
DYNC1I1 affects KCNA5
1 |
1 |
biogrid
No evidence text available
DOLK affects KCNA5
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1 |
biogrid
No evidence text available
DNALI1 affects KCNA5
| 1
| 1
sparser
"Coimmunoprecipitation experiments demonstrated a direct interaction between Kv1.5 and the dynein motor complex in both heterologous cells and rat cardiac myocytes, supporting the role of this complex in Kv1.5 trafficking, which required an intact SH3-binding domain in the Kv1.5 N terminus to occur."
DNAJC18 affects KCNA5
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1 |
biogrid
No evidence text available
DLG1 affects DLG4, and KCNA5
| 1
DLG1 binds DLG4 and KCNA5. 1 / 1
| 1
sparser
"PSD-95 and SAP97 interact with Kv1.5 and recruit channels to a complex which includes caveolin-3 ( xref ; xref )."
DEFB1 affects KCNA5
| 1
| 1
sparser
"We have delineated a Kv1.5 aminoterminal region of up to 90 amino acids (residues 112-201) that is sufficient for interactions of Kv1.5 alpha and Kv beta 1 subunits."
DCTN2 affects KCNA5
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1 |
biogrid
No evidence text available
Calcium affects KCNA5
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Calcium increases the amount of KCNA5. 1 / 1
1 |
bel
"Using inhibitors of PDGF-activated pathways, we found that PDGF-induced upregulation of Kv1.5 and I(K) density involves Src family tyrosine kinases, sphingosine kinase, and intracellular Ca(2+) but not ERK1/2 or phosphatidylinositol 3-kinase pathways."
CYB5R1 affects KCNA5
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1 |
biogrid
No evidence text available
CXCL8 affects KCNA5, and RAB11A
| 1
| 1
sparser
"In both cases, Rab11 mediates cargo protein recycling back to the plasma membrane, and it is not known whether the IL-8 receptors or Kv1.5 directly interact with Rab11."
CLOCK affects KCNA5
| 1
CLOCK activates KCNA5. 1 / 1
| 1
reach
"The DNA microarray showed that KCNA5, KCND2, KCNK3, KCNJ12 and ATP2A2, SLC9A3R2 were augmented by Bmal1 and Clock induction (data not shown)."
CDH2 affects CTTN, and KCNA5
| 1
CDH2 binds CTTN and KCNA5. 1 / 1
| 1
sparser
"It is known that mXinα interacts not only with cortactin ( xref ) but also with p120-catenin ( xref ) and β-catenin ( xref ), suggesting that mXinα may be required for the association of Kv1.5, cortactin, and N-cadherin."
CD244 affects KCNA5, and ion channel
| 1
sparser
"Expression of KCNA5 , which encodes a potassium ion channel protein, was positively associated with water and toe nail arsenic levels."
C1orf43 affects KCNA5
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1 |
biogrid
No evidence text available
C17orf80 affects KCNA5
1 |
biogrid
No evidence text available
C-type affects KCNA5
| 1
C-type inhibits KCNA5. 1 / 1
| 1
reach
"Because C-type inactivated Shaker IR (Starkus et al., 1997) and Kv1.5 (Wang et al., 2000a) channels are able to conduct Na + ions, the current view is that the conformational change at the outer pore mouth involves an incomplete constriction rather than a complete collapse."
BMP2 affects KCNA5
| 1 1
BMP2 increases the amount of KCNA5. 1 / 1
| 1 1
reach
"BMP-2 (100 nM for 18-24 h) significantly (> 2-fold) upregulated mRNA expression of KCNA5, KCNA7, KCNA10, KCNC3, KCNC4, KCNF1, KCNG3, KCNS1, and KCNS3 but downregulated (at least 2-fold) KCNAB1, KCNA2, KCNG2, and KCNV2."
BMI1 affects KCNA5, KCNAB2, and SCMH1
| 1
| 1
sparser
"ChIP assays with antibodies against SCMH1 or BMI1 indicated that both SCMH1 and BMI1 bound to the promoter regions of Kcna5 and Kcnab2 ( xref )."
BAX affects KCNA1, KCNA3, and KCNA5
| 1
KCNA1 binds KCNA3, KCNA5, and BAX. 1 / 1
| 1
sparser
"Here we report that, like Kv1.3, Kv1.1 and Kv1.5 also interact with Bax."
ATP2B4 affects KCNA5
1 |
1 |
biogrid
No evidence text available
ATP2A3 affects KCNA5
1 |
1 |
biogrid
No evidence text available
ARNTL affects KCNA5
| 1
ARNTL activates KCNA5. 1 / 1
| 1
reach
"The DNA microarray showed that KCNA5, KCND2, KCNK3, KCNJ12 and ATP2A2, SLC9A3R2 were augmented by Bmal1 and Clock induction (data not shown)."
ANKLE2 affects KCNA5
1 |
1 |
biogrid
No evidence text available
AMPK affects KCNA5
| 1 1
AMPK inhibits KCNA5. 1 / 1
| 1 1
sparser
"AMPK inhibits Kv1.5 presumably in part by activation of Nedd4- 2 with subsequent clearance of channel protein from the cell membrane."
ADCY3 affects KCNA5
1 |
1 |
biogrid
No evidence text available
ADCK2 affects KCNA5
1 |
1 |
biogrid
No evidence text available
ACTN1 affects KCNA4, and KCNA5
| 1
| 1
sparser
"Substantial further work will be necessary to identify the precise residues required for Kv1.5 and Kv1.4 binding to α-actinin-2."
ACTN1 affects DLG1, and KCNA5
| 1
ACTN1 binds DLG1 and KCNA5. 1 / 1
| 1
sparser
"We found that both Kv1.5 and SAP97 interact strongly with α-actinin2."
ABCD4 affects KCNA5
1 |
1 |
biogrid
No evidence text available
ABCB10 affects KCNA5
1 |
1 |
biogrid
No evidence text available
ABCB1 affects KCNA5
| 1
ABCB1 activates KCNA5. 1 / 1
| 1
reach
"MDR1 expression attenuated KCNA5 block by erythromycin (an MDR1 substrate)."
| 1
reach
"EGCG blocks the atrial specific KCNA5 potassium channel."