INDRA statements for KCNA4

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
KCNA4 affects DLG4
14 7 | 1 11
DLG4 binds KCNA4. 28 / 28
14 7 | 1 7
biogrid
No evidence text available
7477295
biogrid
No evidence text available
11744724
biogrid
No evidence text available
12435606
sparser
"When domains that mediate the interaction of Kv1.4 and PSD-95 were disrupted, Kv1.4 localized nonspecifically."
10402201
hprd
No evidence text available
9581762
sparser
"Defined substitutions within the four C-terminal residues could abolish Kv1.4 interaction with PSD-95 (as measured in the yeast two-hybrid assay), and all the mutations that abolished Kv1.4 binding to PSD-95 also completely abolished coclustering in transfected COS cells ( Table 1 )."
8938729
biogrid
No evidence text available
11723117
biogrid
No evidence text available
11997254
hprd
No evidence text available
7477295
biogrid
No evidence text available
11723117
sparser
"However, the yeast cell growth was slowed by halothane ( xref ) and isoflurane ( xref ) in a dose-dependent manner, indicating that these anesthetics dose-dependently inhibit PDZ domain-mediated protein-protein interactions between PSD-95 and Kv1.4."
25654436
hprd
No evidence text available
8601796
hprd
No evidence text available
12435606
sparser
"The strength of this interaction in the yeast two-hybrid system was similar to the binding of the Shaker-type K + channel Kv1.4 to the PDZ1+2 domains of PSD-95."
12067714
hprd
No evidence text available
11744724
sparser
"Although direct interaction of E-dlg PDZ domains with Kv1.4 has yet to be demonstrated, these data are consistent with a function for E-dlg in regulating development and transmission in the synapse."
18618587
hprd
No evidence text available
8938729
biogrid
No evidence text available
7477295
sparser
"To determine whether inhaled anesthetics disrupt PDZ domain-mediated protein-protein interactions in a physiological setting, we used a co-immunoprecipitation assay to detect in vivo binding of PSD-95 to Kv1.4."
25654436
biogrid
No evidence text available
11723117
hprd
No evidence text available
11723117
biogrid
No evidence text available
9581762
sparser
"In the same assay, an H 6 -tagged fusion protein of PDZ1-2 of PSD-95 bound specifically to Kv1.4 ( Figure 1B , right)."
11931740
biogrid
No evidence text available
8938729
biogrid
No evidence text available
8601796
biogrid
No evidence text available
12435606
biogrid
No evidence text available
8938729
biogrid
No evidence text available
12435606
DLG4 binds KCNA4 and KCND2. 1 / 1
| 1
sparser
"Because both Kv1.4 and Kv4.2 interact with postsynaptic density protein 95 (PSD-95), which is acylated (specifically, palmitoylated), we examined whether PSD-95 can recruit these channels to lipid rafts."
14559911
DLG1 binds DLG4 and KCNA4. 1 / 1
| 1
sparser
"Taken together, these results indicate that Kv1.4 forms a non-covalent complex with both PSD-95 and SAP97 that can be disrupted by denaturing detergents."
8938729
DLG4 binds GRIN2A and KCNA4. 1 / 1
| 1
sparser
"Effects of Halothane and Isoflurane on PDZ Domain-mediated Interactions between NMDA Receptor-interacting Protein PSD-95 and Kv1.4."
25654436
DLG4 binds KCNA4 and FAS2. 1 / 1
| 1
sparser
"Unlike wild type PSD-95, the cysteine mutant of PSD-95 cannot form a ternary complex with Kv1.4 and the cell adhesion molecule Fasciclin II."
9867876
KCNA4 affects DLG1
4 2 | 2 1
DLG1 binds KCNA4. 8 / 8
4 2 | 1 1
biogrid
No evidence text available
12860415
hprd
No evidence text available
7477295
reach
"KCNA4 interacts with several molecules including synaptotagmin I, DLG1 and DLG2."
27582084
hprd
No evidence text available
12860415
biogrid
No evidence text available
11997254
biogrid
No evidence text available
7477295
sparser
"This biochemical association presumably underlies the coclustering seen when the K + channel is expressed with PSD-95 or SAP97, and further supports the idea that the intracellular SAP97/Kv1.4 coclusters are due to specific binding of Kv1.4 to SAP97."
8938729
biogrid
No evidence text available
8938729
DLG1 binds DLG4 and KCNA4. 1 / 1
| 1
sparser
"Taken together, these results indicate that Kv1.4 forms a non-covalent complex with both PSD-95 and SAP97 that can be disrupted by denaturing detergents."
8938729
SRC affects KCNA4
1 | 5
SRC phosphorylates KCNA4.
| 3
SRC phosphorylates KCNA4. 3 / 3
| 3
sparser
"We then tried to identify tyrosine residues phosphorylated by c-Src on HK1 and HK2 by employing affinity purification combined with mass spectrometry techniques."
28054552
sparser
"Acting as a tyrosine kinase, c-Src regulates cell functions by phosphorylating and activating a variety of its substrate proteins xref xref , therefore, we examined whether c-Src could phosphorylate HK1 and HK2."
28054552
sparser
"Both HK1 and HK2 are phosphorylated by c-Src."
28054552
SRC activates KCNA4.
| 2
SRC activates KCNA4. 2 / 2
| 2
sparser
"We next explored the biological significance underlying c-Src-induced activation of HK1 and HK2."
28054552
sparser
"PDGF could robustly trigger glucose uptake in both HeLa and A549 cells, and this effect was suppressed either by PP2 treatment ( xref and xref ) or by knockdown of HK1 ( xref ) or HK2 ( xref ), indicating that c-Src activation of HK1 and HK2 is essential for PDGF-stimulated glycolysis."
28054552
SRC binds KCNA4.
1 |
SRC binds KCNA4. 1 / 1
1 |
biogrid
No evidence text available
11149959
LNX1 affects KCNA4
3 |
KCNA4 binds LNX1. 3 / 3
3 |
biogrid
No evidence text available
22889411
biogrid
No evidence text available
22889411
biogrid
No evidence text available
22087225
KCNA4 affects ACTN1
| 3
ACTN1 binds KCNA4. 2 / 2
| 2
sparser
"Since α-actinin-2 fused to the GAL4 DNA binding domain also activates the reporter genes (data not shown), the yeast two-hybrid system could not indicate to us whether Kv1.4 and α-actinin-2 interact."
11389904
sparser
"The same approach was used to determine whether the Kv1.4 N-terminus also bound α-actinin-2."
11389904
ACTN1 binds KCNA4 and KCNA5. 1 / 1
| 1
sparser
"Substantial further work will be necessary to identify the precise residues required for Kv1.5 and Kv1.4 binding to α-actinin-2."
11389904
FSCN1 affects KCNA4
| 3
FSCN1 inhibits KCNA4.
| 1
FSCN1 inhibits KCNA4. 1 / 1
| 1
reach
"Neither AAV5-Dnmt3a shRNA nor AAV5-Cre affected SNL induced reductions of Kcna1 and Kcna4 mRNAs in the injured DRG (XREF_FIG)."
28270689
FSCN1 decreases the amount of KCNA4.
| 1
FSCN1 decreases the amount of KCNA4. 1 / 1
| 1
reach
"SNL gradually reduced the mRNA levels of Kcna4, Kcnd2, Kcnq2 and Kcnma1 in the DRG over a 4-week period (XREF_FIG)."
26551542
FSCN1 activates KCNA4.
| 1
FSCN1 activates KCNA4. 1 / 1
| 1
reach
"Intrathecal administration of BIX01294 also blocked the SNL induced increase in the level of H3K9me2, a marker of G9a activity, and reversed SNL induced downregulation of Oprm1 mRNA, Oprk1 mRNA, Oprd1 mRNA, Kcna2 mRNA, and Kcna4 mRNA, the downstream targets of G9a, in the ipsilateral L5 DRG."
31497620
ACTN1 affects KCNA4
| 3
ACTN1 binds KCNA4. 2 / 2
| 2
sparser
"Since α-actinin-2 fused to the GAL4 DNA binding domain also activates the reporter genes (data not shown), the yeast two-hybrid system could not indicate to us whether Kv1.4 and α-actinin-2 interact."
11389904
sparser
"The same approach was used to determine whether the Kv1.4 N-terminus also bound α-actinin-2."
11389904
ACTN1 binds KCNA4 and KCNA5. 1 / 1
| 1
sparser
"Substantial further work will be necessary to identify the precise residues required for Kv1.5 and Kv1.4 binding to α-actinin-2."
11389904
SYT1 affects KCNA4
| 1 1
SYT1 binds KCNA4. 2 / 2
| 1 1
reach
"KCNA4 interacts with several molecules including synaptotagmin I, DLG1 and DLG2."
27582084
sparser
"Mutagenesis experiments indicated that synaptotagmin I interacted with the N-terminus of Kv1.4 and thus delayed its N-type fast inactivation."
24423395
SNTA1 affects KCNA4
1 1 |
SNTA1 binds KCNA4. 2 / 2
1 1 |
biogrid
No evidence text available
15123239
hprd
No evidence text available
16637659
SIRT1 affects KCNA4
2 |
SIRT1 binds KCNA4. 2 / 2
2 |
biogrid
No evidence text available
23390957
biogrid
No evidence text available
23390957
SAT1 affects KCNA4
1 1 |
SAT1 binds KCNA4. 2 / 2
1 1 |
biogrid
No evidence text available
16169070
hprd
No evidence text available
16169070
NMA111 affects KCNA4
| 1 1
KCNA4 binds NMA111. 1 / 1
| 1
reach
"GST-PDZ1 was able to bind KCNA4 and PLEKHG5."
22087225
GST binds PLEKHG5, KCNA4, and NMA111. 1 / 1
| 1
sparser
"GST-PDZ1 was able to bind KCNA4 and PLEKHG5."
22087225
NDUFA4L2 affects KCNA4
1 1 |
NDUFA4L2 binds KCNA4. 2 / 2
1 1 |
hprd
No evidence text available
16169070
biogrid
No evidence text available
16169070
KCNA4 affects potassium(1+)
| 1 1
KCNA4 binds potassium(1+).
| 1
Potassium(1+) binds KCNA2 and KCNA4. 1 / 1
| 1
sparser
"We present here biochemical evidence that Kv1.4 and Kv1.2, two K+ channel subunits of the Shaker subfamily, co-assemble in rat brain."
8361540
KCNA4 activates potassium(1+).
| 1
KCNA4 activates potassium(1+). 1 / 1
| 1
reach
"For example, immunohistochemical evidence has suggested that the " A-type " potassium current from PVN-RVLM neurones is mediated by KCNA4 (K v 1.4) and/or KCND3 (K v 4.3) channel subunits."
30034342
KCNA4 affects SYT1
| 1 1
SYT1 binds KCNA4. 2 / 2
| 1 1
reach
"KCNA4 interacts with several molecules including synaptotagmin I, DLG1 and DLG2."
27582084
sparser
"Mutagenesis experiments indicated that synaptotagmin I interacted with the N-terminus of Kv1.4 and thus delayed its N-type fast inactivation."
24423395
KCNA4 affects SNTA1
1 1 |
SNTA1 binds KCNA4. 2 / 2
1 1 |
biogrid
No evidence text available
15123239
hprd
No evidence text available
16637659
KCNA4 affects SIRT1
2 |
SIRT1 binds KCNA4. 2 / 2
2 |
biogrid
No evidence text available
23390957
biogrid
No evidence text available
23390957
KCNA4 affects SAT1
1 1 |
SAT1 binds KCNA4. 2 / 2
1 1 |
biogrid
No evidence text available
16169070
hprd
No evidence text available
16169070
KCNA4 affects NMA111
| 1 1
KCNA4 binds NMA111. 1 / 1
| 1
reach
"GST-PDZ1 was able to bind KCNA4 and PLEKHG5."
22087225
GST binds PLEKHG5, KCNA4, and NMA111. 1 / 1
| 1
sparser
"GST-PDZ1 was able to bind KCNA4 and PLEKHG5."
22087225
KCNA4 affects NDUFA4L2
1 1 |
NDUFA4L2 binds KCNA4. 2 / 2
1 1 |
hprd
No evidence text available
16169070
biogrid
No evidence text available
16169070
KCNA4 affects ERBIN
2 |
ERBIN binds KCNA4. 2 / 2
2 |
biogrid
No evidence text available
15123239
biogrid
No evidence text available
11278603
KCNA4 affects DLGAP1
1 | 1 1
DLGAP1 binds KCNA4. 2 / 2
1 | 1 1
hprd
No evidence text available
9024696
sparser
"Thus, there is no direct association of Kv1.4 and GKAP."
9024696
KCNA4 affects DLG2
1 1 |
DLG2 binds KCNA4. 2 / 2
1 1 |
biogrid
No evidence text available
11997254
hprd
No evidence text available
11997254
ERBIN affects KCNA4
2 |
ERBIN binds KCNA4. 2 / 2
2 |
biogrid
No evidence text available
15123239
biogrid
No evidence text available
11278603
DLGAP1 affects KCNA4
1 | 1 1
DLGAP1 binds KCNA4. 2 / 2
1 | 1 1
hprd
No evidence text available
9024696
sparser
"Thus, there is no direct association of Kv1.4 and GKAP."
9024696
DLG2 affects KCNA4
1 1 |
DLG2 binds KCNA4. 2 / 2
1 1 |
biogrid
No evidence text available
11997254
hprd
No evidence text available
11997254
Quercetin affects KCNA4
| 1
Quercetin inhibits KCNA4. 1 / 1
| 1
sparser
"Our study demonstrates that quercetin inhibits cell growth of nasopharyngeal carcinoma cell lines HK1 and CNE2 by inhibiting cell cycle progression to S phase."
14767529
Polyunsaturated fatty acid anion affects KCNA4
| 1
Polyunsaturated fatty acid anion inhibits KCNA4. 1 / 1
| 1
sparser
"PUFAs inhibited wild-type Kv1.4 during repetitive pulsing as a result of slowing of recovery from inactivation."
27281482
Nodal2-a affects KCNA4
| 1
KCNA4 binds nodal2-a. 1 / 1
| 1
sparser
"PSD-95, for example, can interact with both the glutamate receptor subunit NR2 and the Shaker-type K channel Kv1.4 [], but NR2 is found on the dendrites while the Shaker-type K channel localizes on subdomains of the axon []."
9714822
Hsa-miR-8485 affects KCNA4
1 |
Transcriptionally active hsa-miR-8485 decreases the amount of KCNA4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-603 affects KCNA4
1 |
Transcriptionally active hsa-miR-603 decreases the amount of KCNA4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4789-5p affects KCNA4
1 |
Transcriptionally active hsa-miR-4789-5p decreases the amount of KCNA4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4789-3p affects KCNA4
1 |
Transcriptionally active hsa-miR-4789-3p decreases the amount of KCNA4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3941 affects KCNA4
1 |
Transcriptionally active hsa-miR-3941 decreases the amount of KCNA4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-377-3p affects KCNA4
1 |
Transcriptionally active hsa-miR-377-3p decreases the amount of KCNA4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3682-5p affects KCNA4
1 |
Transcriptionally active hsa-miR-3682-5p decreases the amount of KCNA4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-362-3p affects KCNA4
1 |
Transcriptionally active hsa-miR-362-3p decreases the amount of KCNA4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-335-5p affects KCNA4
1 |
Transcriptionally active hsa-miR-335-5p decreases the amount of KCNA4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18185580
Hsa-miR-329-3p affects KCNA4
1 |
Transcriptionally active hsa-miR-329-3p decreases the amount of KCNA4. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Glucosamine affects KCNA4
| 1
Glucosamine inhibits KCNA4. 1 / 1
| 1
sparser
"Out of these, GK3, HK1 and HK2 were inhibited by mannoheptulose and glucosamine, known inhibitors of hexokinase activity."
10680171
TGFB1 affects KCNA4
| 1
TGFB1 increases the amount of KCNA4. 1 / 1
| 1
reach
"Taken together, these results suggest that TGFbeta1 modulates the regulation of KCNA4 gene expression in individual nociceptors."
22963239
SNTG1 affects KCNA4
1 |
SNTG1 binds KCNA4. 1 / 1
1 |
hprd
No evidence text available
11352924
SIGMAR1 affects KCNA4
| 1
KCNA4 binds SIGMAR1. 1 / 1
| 1
sparser
"Aydar and colleagues [ xref ] demonstrated a functional interaction between the Sig-1R and Kv1.4 in the absence of ligands."
26869505
SH affects KCNA4
| 1
KCNA4 binds SH. 1 / 1
| 1
sparser
"While Kv1.4 and Sh form clusters with PSD-95 in ∼60-70% of cotransfected cells, clusters of Kv1.1, Kv1.2, and Kv1.3 were detected only in 10–20% of cotransfected cells ( Fig. 4 )."
8938729
PRKACA affects KCNA4
1 |
PRKACA phosphorylates KCNA4 on T601. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PATJ affects KCNA4
1 |
PATJ binds KCNA4. 1 / 1
1 |
hprd
No evidence text available
16637659
NMDAR affects KCNA4
| 1
KCNA4 binds NMDAR. 1 / 1
| 1
sparser
"In this context, we note that monomeric interfering peptides conveyed into cells by the Antennapedia method are effective at disrupting PDZ3-mediated interactions of PSD-95 with CRIPT, but ineffective at disrupting PDZ12-mediated interactions with NMDA receptors and Kv1.4 (C.S. & M.S., unpublished observations)."
12614619
NEU1 affects KCNA4
1 |
KCNA4 binds NEU1. 1 / 1
1 |
biogrid
No evidence text available
10896669
Mir543 affects KCNA4
| 1
Mir543 activates KCNA4. 1 / 1
| 1
reach
"The Kcna4 gene is targeted by Mir543 and Mir301."
26822703
Mir301 affects KCNA4
| 1
Mir301 activates KCNA4. 1 / 1
| 1
reach
"The Kcna4 gene is targeted by Mir543 and Mir301."
26822703
MPP2 affects KCNA4
| 1
KCNA4 binds MPP2. 1 / 1
| 1
reach
"KCNA4 interacts with several molecules including synaptotagmin I, DLG1 and DLG2."
27582084
KCNRG affects KCNA4
1 |
KCNRG binds KCNA4. 1 / 1
1 |
biogrid
No evidence text available
19968958
KCNA4 affects nodal2-a
| 1
KCNA4 binds nodal2-a. 1 / 1
| 1
sparser
"PSD-95, for example, can interact with both the glutamate receptor subunit NR2 and the Shaker-type K channel Kv1.4 [], but NR2 is found on the dendrites while the Shaker-type K channel localizes on subdomains of the axon []."
9714822
KCNA4 affects SRC
1 |
SRC binds KCNA4. 1 / 1
1 |
biogrid
No evidence text available
11149959
KCNA4 affects SNTG1
1 |
SNTG1 binds KCNA4. 1 / 1
1 |
hprd
No evidence text available
11352924
KCNA4 affects SIGMAR1
| 1
KCNA4 binds SIGMAR1. 1 / 1
| 1
sparser
"Aydar and colleagues [ xref ] demonstrated a functional interaction between the Sig-1R and Kv1.4 in the absence of ligands."
26869505
KCNA4 affects SH
| 1
KCNA4 binds SH. 1 / 1
| 1
sparser
"While Kv1.4 and Sh form clusters with PSD-95 in ∼60-70% of cotransfected cells, clusters of Kv1.1, Kv1.2, and Kv1.3 were detected only in 10–20% of cotransfected cells ( Fig. 4 )."
8938729
KCNA4 affects PATJ
1 |
PATJ binds KCNA4. 1 / 1
1 |
hprd
No evidence text available
16637659
KCNA4 affects NMDAR
| 1
KCNA4 binds NMDAR. 1 / 1
| 1
sparser
"In this context, we note that monomeric interfering peptides conveyed into cells by the Antennapedia method are effective at disrupting PDZ3-mediated interactions of PSD-95 with CRIPT, but ineffective at disrupting PDZ12-mediated interactions with NMDA receptors and Kv1.4 (C.S. & M.S., unpublished observations)."
12614619
KCNA4 affects NEU1
1 |
KCNA4 binds NEU1. 1 / 1
1 |
biogrid
No evidence text available
10896669
KCNA4 affects MPP2
| 1
KCNA4 binds MPP2. 1 / 1
| 1
reach
"KCNA4 interacts with several molecules including synaptotagmin I, DLG1 and DLG2."
27582084
KCNA4 affects KCNRG
1 |
KCNRG binds KCNA4. 1 / 1
1 |
biogrid
No evidence text available
19968958
KCNA4 affects KCNJ2, PLN, and RYR2
| 1
RYR2 binds KCNA4, KCNJ2, and PLN. 1 / 1
| 1
sparser
"In terms of ion transporter‐ forming proteins, Kir2.1, RYR2, phospholamban, and Kv1.4 are highly expressed in ventricles xref ."
28577296
KCNA4 affects FYN
1 |
FYN binds KCNA4. 1 / 1
1 |
biogrid
No evidence text available
11149959
KCNA4 affects DLG3
1 |
DLG3 binds KCNA4. 1 / 1
1 |
hprd
No evidence text available
16637659
KCNA4 affects CASK
1 |
CASK binds KCNA4. 1 / 1
1 |
hprd
No evidence text available
16637659
KCNA4 affects ACTN2
1 | 1
ACTN2 binds KCNA4. 1 / 1
1 | 1
hprd
No evidence text available
11389904
KCNA2 affects KCNA4, and potassium(1+)
| 1
Potassium(1+) binds KCNA2 and KCNA4. 1 / 1
| 1
sparser
"We present here biochemical evidence that Kv1.4 and Kv1.2, two K+ channel subunits of the Shaker subfamily, co-assemble in rat brain."
8361540
KCNA2 affects KCNA4, and MME
| 1
KCNA2 binds KCNA4 and MME. 1 / 1
| 1
sparser
"Reciprocal coimmunoprecipitation experiments revealed that the beta-subunit polypeptides are associated with Kv1.2 and Kv1.4, but not Kv2.1, alpha-subunits."
7623158
KCNA1 affects KCNA4, and LGI1
| 1
KCNA1 binds KCNA4 and LGI1. 1 / 1
| 1
sparser
"Both Kv1.1 and LGI1 are co-assembled with KV1.4 and Kvbeta1."
24177143
GST affects KCNA4, NMA111, and PLEKHG5
| 1
GST binds PLEKHG5, KCNA4, and NMA111. 1 / 1
| 1
sparser
"GST-PDZ1 was able to bind KCNA4 and PLEKHG5."
22087225
GSK503 affects KCNA4
| 1
GSK503 decreases the amount of KCNA4. 1 / 1
| 1
reach
"GSK503 largely normalized the mRNA levels of Kcnd2, Kcnq2 and Kcnma1 but decreased the Kcna4 mRNA level in the injured DRG (XREF_FIG)."
26551542
FYN affects KCNA4
1 |
FYN binds KCNA4. 1 / 1
1 |
biogrid
No evidence text available
11149959
F12 affects KCNA4
| 1
F12 inhibits KCNA4. 1 / 1
| 1
sparser
"Functional modulation of endogenous Kv1.4 inactivation by f12."
7649300
DLG4 affects KCNA4, and KCND2
| 1
DLG4 binds KCNA4 and KCND2. 1 / 1
| 1
sparser
"Because both Kv1.4 and Kv4.2 interact with postsynaptic density protein 95 (PSD-95), which is acylated (specifically, palmitoylated), we examined whether PSD-95 can recruit these channels to lipid rafts."
14559911
DLG4 affects GRIN2A, and KCNA4
| 1
DLG4 binds GRIN2A and KCNA4. 1 / 1
| 1
sparser
"Effects of Halothane and Isoflurane on PDZ Domain-mediated Interactions between NMDA Receptor-interacting Protein PSD-95 and Kv1.4."
25654436
DLG4 affects FAS2, and KCNA4
| 1
DLG4 binds KCNA4 and FAS2. 1 / 1
| 1
sparser
"Unlike wild type PSD-95, the cysteine mutant of PSD-95 cannot form a ternary complex with Kv1.4 and the cell adhesion molecule Fasciclin II."
9867876
DLG3 affects KCNA4
1 |
DLG3 binds KCNA4. 1 / 1
1 |
hprd
No evidence text available
16637659
DLG1 affects DLG4, and KCNA4
| 1
DLG1 binds DLG4 and KCNA4. 1 / 1
| 1
sparser
"Taken together, these results indicate that Kv1.4 forms a non-covalent complex with both PSD-95 and SAP97 that can be disrupted by denaturing detergents."
8938729
DEFB4A affects KCNA4, and Kv
| 1
DEFB4A binds KCNA4 and Kv. 1 / 1
| 1
sparser
"Like the wild-type Kv beta 2, both types of mutation increased the rate of inactivation of Kv1.4, confirming the physical association of mutant Kv beta 2 subunits with Kv1.4."
11024060
CASK affects KCNA4
1 |
CASK binds KCNA4. 1 / 1
1 |
hprd
No evidence text available
16637659
CAMK2_complex affects KCNA4
| 1
CAMK2_complex phosphorylates KCNA4. 1 / 1
| 1
sparser
"CaMKII phosphorylation of an amino-terminal residue of KV1.4 leads to slowing of inactivation gating and accelerated recovery from N-type inactivated states."
9133364
ACTN2 affects KCNA4
1 | 1
ACTN2 binds KCNA4. 1 / 1
1 | 1
hprd
No evidence text available
11389904
ACTN1 affects KCNA4, and KCNA5
| 1
ACTN1 binds KCNA4 and KCNA5. 1 / 1
| 1
sparser
"Substantial further work will be necessary to identify the precise residues required for Kv1.5 and Kv1.4 binding to α-actinin-2."
11389904
AAV5-GFP affects KCNA4
| 1
AAV5-GFP increases the amount of KCNA4. 1 / 1
| 1
reach
"Injection of AAV5-Cre, but not AAV5-GFP, rescued the expression of Kcna2 and Kcna4 mRNAs and proteins in the axotomized DRG on day 7 post-SNL (XREF_FIG)."
27874088
3,3',5-triiodo-L-thyronine affects KCNA4
| 1
3,3',5-triiodo-L-thyronine decreases the amount of KCNA4. 1 / 1
| 1
reach
"T3 stimulation enhanced KCND2 and KCND3 expression and decreased KCNA4 transcription, while KCNIP2 remained unaffected."
19171649