INDRA statements for KCNA3

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
KcsA affects KCNA3
| 15
KCNA3 binds kcsA. 11 / 11
| 11
sparser
"This could indicate that these two classes of ligands bind to different sites of KcsA-Kv1.3."
26074010
sparser
"This result suggests that an ensemble of toxin-bound states, rather than a single, complexed structure, may be formed by KTX binding to KcsA-Kv1.3."
18462679
sparser
"To assemble the KcsA-Kv1.3 containing Nanodisc, KcsA-Kv1.3 (tetramer), biotin-MSP1D1-D73C, and DMPC were mixed at 1:8:320 molar ratio in the presence of 14 mM sodium cholate in the assembly buffer."
26074010
sparser
"The monodisperse state ( Fig. 1 D) and Stokes diameters of the assembled KcsA-Kv1.3 and empty Nanodiscs were determined by size exclusion chromatography using a Beckman System Gold HPLC (Beckman Coulter, CA) to be 11.0 nm and 9.5 nm, respectively ( Fig. 1 E)."
26074010
sparser
"We grafted selected residues of the pore region of the S5–S6 domain of human Kv1.3 channel onto the M1–M2 region of KcsA to enable binding of therapeutic inhibitors of Kv1.3 [27,29] to the KcsA-Kv1.3 chimeric protein ( Fig. 1 A)."
26074010
sparser
"Most of the KTX molecules remained stably bound to KcsA-Kv1.3 in these simulations ( Figure 5 B)."
18462679
sparser
"Thermodynamic measurements of ion binding using isothermal titration calorimetry (ITC) report a K d of ∼0.43 mM for K + binding. xref Electrophysiological experiments on the KcsA-Kv1.3 chimera report two high affinity binding sites in the pore: an inner site that has a K d of 6.5 µM and the outer site has a K d of 0.9 mM."
20600123
sparser
"Our structural model revealed a mechanism of cooperative toxin-induced conformational changes that accounts both for the signal changes observed in solid-state NMR and for the tight interaction between KcsA-Kv1.3 and Kaliotoxin."
18462679
sparser
"Therefore, BSI was a more favorable option to determine the interactions of small molecule inhibitors with KcsA-Kv1.3 Nanodiscs."
26074010
sparser
"We have studied the interactions between KcsA-Kv1.3 nano-disc and its inhibitors, including two peptides (ShK and PEG-ShK) and a small molecule (compound 1)."
26752355
sparser
"To demonstrate this capability, we measured compound 1 interaction with KcsA-Kv1.3 nanodisc in horse serum."
26752355
KCNA1 binds KCNA3 and kcsA. 1 / 1
| 1
sparser
"We demonstrate that fluorescently labeled agitoxin 2 binds specifically to high-affinity and lower-affinity sites of KcsA-Kv1.3 and KcsA-Kv1.1, respectively, at the membrane of spheroplasts."
18649142
KCN binds KCNA3 and kcsA. 1 / 1
| 1
sparser
"Our study provides a structural model for the chemical shift changes observed upon high-affinity binding of KTX to the chimeric potassium channel KcsA-Kv1.3."
18462679
TACR1 binds KCNA3 and kcsA. 1 / 1
| 1
sparser
"Although the SPR and BSI studies both showed sub-nanomolar interaction between KcsA-Kv1.3 and its peptide inhibitors, the affinities for both peptides appeared to be 4–5 fold weaker by BSI than the values determined by SPR."
26074010
KCNA3 binds kcsA and ion channel. 1 / 1
| 1
sparser
"The control fiber tip was dipped in 86 nM ShK and no response was observed ( xref ), which confirms that the oscillation amplitude change shown in xref was due to the specific binding of ShK to the KcsA-Kv1.3 ion channel proteins."
26752355
KCNA3 affects DLG4
2 2 | 1 7
DLG4 binds KCNA3. 9 / 9
2 2 | 1 5
biogrid
No evidence text available
17854350
sparser
"Therefore, a functional Kv1.3-PSD-95 interaction is required not only for correct Kv1.3 redistribution in the vicinity of IS formation but also to prevent a massive internalization of the channel as a consequence of PKC-dependent immunosuppressive insults."
28186199
sparser
"Through patch-clamp electrophysiology, immunochemistry, and co-immunoprecipitation, we found that while Kv1.3 and PSD-95 alone interact via the canonical C-terminal PDZ recognition motif of the channel, this molecular site of interaction acts to cluster the channels but the PSD-95 SH(3)-guanylate kinase domain functionally modulates Kv1.3 activity via two proline-rich domains in its N- and C-terminal."
17854350
hprd
No evidence text available
8938729
biogrid
No evidence text available
21726550
sparser
"In T-lymphocytes, PSD-95 interacts with Kv1.3, inducing clustering and recruiting Kv1.3 into the IS xref ."
28186199
sparser
"Kv1.3 interacts with PSD-95 through a C-terminal PDZ-binding domain, defined by the last three residues of the channel (Thr 523 -Asp 524 -Val 525 ) xref ."
28186199
hprd
No evidence text available
12435606
sparser
"PSD-95 associated with Kv1.3 in HEK-293 cells ( xref ), affecting the channel membrane distribution ( xref )."
28186199
DLG4 binds INSR and KCNA3. 1 / 1
| 1
sparser
"Thus, insulin IND-treatment evokes activation of IR in situ and enhances the scaffolding association of Kv1.3, IR, and PSD-95 protein complexes."
19458242
DLG1 binds DLG4 and KCNA3. 1 / 1
| 1
sparser
"Disruption of the interaction between PSD-95 or SAP97 and Kv1.3 in Jurkat was realized by the expression of a C-terminal truncated Kv1.3, which lacks the binding domain for these proteins, or by the knockdown of the expression of PSD-95 or SAP97 using specific shRNA."
23553419
SRC affects KCNA3
2 1 4 | 1 2 2
SRC phosphorylates KCNA3.
2 1 2 | 1
SRC phosphorylates KCNA3 on Y499. 2 / 2
1 1 |
biopax:phosphositeplus
No evidence text available
signor
"The shaker family k+ channel protein, kv1.3, is tyrosine phosphorylated by v-src kinase at tyr137 and tyr449 to modulate current magnitude and kinetic properties."
11812778
SRC phosphorylates KCNA3 on Y187. 2 / 2
1 1 |
biopax:phosphositeplus
No evidence text available
signor
"The shaker family k+ channel protein, kv1.3, is tyrosine phosphorylated by v-src kinase at tyr137 and tyr449 to modulate current magnitude and kinetic properties."
11812778
SRC phosphorylates KCNA3 on tyrosine. 1 / 1
| 1
rlimsp
"In HEK 293 cells, co-expression of Kv1.3 plus v-Src with Grb10 causes a decrease in v-Src-induced Kv1.3 tyrosine phosphorylation and a reversal of v-Src-induced Kv1.3 current suppression, increase in inactivation time constant (tau(inact)), and disruption of cumulative inactivation properties."
11812778
Kinase-active SRC phosphorylates KCNA3 on Y447. 1 / 1
1 |
bel
"PhosphoElm data from PMID 15212693"
11812778
SRC activates KCNA3.
2 | 1
SRC activates KCNA3. 2 / 2
2 | 1
signor
"The shaker family k+ channel protein, kv1.3, is tyrosine phosphorylated by v-src kinase at tyr137 and tyr449 to modulate current magnitude and kinetic properties."
11812778
signor
"The shaker family k+ channel protein, kv1.3, is tyrosine phosphorylated by v-src kinase at tyr137 and tyr449 to modulate current magnitude and kinetic properties."
11812778
SRC inhibits KCNA3.
| 1 1
SRC inhibits KCNA3. 1 / 1
| 1 1
sparser
"Kv1.3 is strongly inhibited by activated Src in rat microglia [ xref ]."
27009332
SRC binds KCNA3.
| 1
SRC binds KCNA3. 1 / 1
| 1
sparser
"This interaction may be facilitated by a multiprotein complex because, in cultured microglia, the endogenous Kv1.3 and src proteins both bind to the scaffolding protein, post-synaptic density protein 95 (PSD-95)."
10886336
NTRK2 affects KCNA3
4 6 |
NTRK2 phosphorylates KCNA3.
4 3 |
NTRK2 phosphorylates KCNA3 on Y161. 2 / 2
1 1 |
signor
"Previously we have shown that acute brain-derived neurotrophic factor (bdnf) activation of neurotrophin receptor tyrosine kinase b (trkb) suppresses the shaker voltage-gated potassium channel (kv1.3) via phosphorylation of multiple tyrosine residues in the n and c terminal aspects of the channel protein."
19166614
biopax:phosphositeplus
No evidence text available
NTRK2 phosphorylates KCNA3 on Y163. 2 / 2
1 1 |
biopax:phosphositeplus
No evidence text available
signor
"Previously we have shown that acute brain-derived neurotrophic factor (bdnf) activation of neurotrophin receptor tyrosine kinase b (trkb) suppresses the shaker voltage-gated potassium channel (kv1.3) via phosphorylation of multiple tyrosine residues in the n and c terminal aspects of the channel protein."
19166614
NTRK2 phosphorylates KCNA3 on Y162. 2 / 2
1 1 |
signor
"Previously we have shown that acute brain-derived neurotrophic factor (bdnf) activation of neurotrophin receptor tyrosine kinase b (trkb) suppresses the shaker voltage-gated potassium channel (kv1.3) via phosphorylation of multiple tyrosine residues in the n and c terminal aspects of the channel protein."
19166614
biopax:phosphositeplus
No evidence text available
NTRK2 phosphorylates KCNA3 on Y499. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
NTRK2 inhibits KCNA3.
3 |
NTRK2 inhibits KCNA3. 3 / 3
3 |
signor
"Previously we have shown that acute brain-derived neurotrophic factor (bdnf) activation of neurotrophin receptor tyrosine kinase b (trkb) suppresses the shaker voltage-gated potassium channel (kv1.3) via phosphorylation of multiple tyrosine residues in the n and c terminal aspects of the channel protein."
19166614
signor
"Previously we have shown that acute brain-derived neurotrophic factor (bdnf) activation of neurotrophin receptor tyrosine kinase b (trkb) suppresses the shaker voltage-gated potassium channel (kv1.3) via phosphorylation of multiple tyrosine residues in the n and c terminal aspects of the channel protein."
19166614
signor
"Previously we have shown that acute brain-derived neurotrophic factor (bdnf) activation of neurotrophin receptor tyrosine kinase b (trkb) suppresses the shaker voltage-gated potassium channel (kv1.3) via phosphorylation of multiple tyrosine residues in the n and c terminal aspects of the channel protein."
19166614
BAX affects KCNA3
2 1 | 3 7
BAX binds KCNA3.
2 1 | 1 5
KCNA3 binds BAX. 7 / 7
2 1 | 1 4
sparser
"Our results point to a physiologically relevant interaction of Bax with Kv1.3 and further indicate a crucial role of a distinct lysine in determining the proapoptotic character of Bcl2-family proteins."
20885444
biogrid
No evidence text available
20114030
biogrid
No evidence text available
20114030
hprd
No evidence text available
18818304
sparser
"Strongly relating potassium channels with the regulation of apoptosis, an physical interaction between Bax and Kv1.3 was reported in lymphocytes, which appeared as necessary for Bax-induced apoptosis xref ."
22723988
sparser
"We have also shown that Bax binds to the pore of Kv1.3, subsequently resulting in the inhibition of Kv1.3 activity in isolated mitochondria."
22496117
sparser
"To gain insight into the mechanism of Bax-Kv1.3 interaction, we mutated Glu158 of Bcl-x(L) (corresponding to K128 in Bax) to lysine."
20885444
KCNA1 binds KCNA3, KCNA5, and BAX. 1 / 1
| 1
sparser
"Here we report that, like Kv1.3, Kv1.1 and Kv1.5 also interact with Bax."
22856664
BAX inhibits KCNA3.
| 2 2
BAX inhibits KCNA3. 2 / 2
| 2 2
sparser
"We have previously shown that Kv1.3 is inhibited by Bax and contributes to a series of apoptotic events at the level of mitochondria (Szabò et al, xref ; Szabò et al, xref )."
22496117
sparser
"Indeed, tBid initiates a CsA-sensitive process of cristae remodeling that increases cytochrome c availability in the intermembrane space, which is consistent with a PT-dependent facilitation of cytochrome c release even when the outer membrane is intact (Scorrano et al., xref , xref ); and Bax inhibits the mitochondrial inner membrane potassium channel Kv1.3 (Szabó et al., xref ), a proapoptotic effect that critically depends on Bax residue K128 and is abrogated by a K128E mutation, while an E158K mutation in antiapoptotic Bcl-xL (position 158 of Bcl-xL corresponds to position 128 of Bax) turns Bcl-xL into a proapoptotic protein (Szabó et al., xref )."
23675351
MAPK affects KCNA3
| 9
MAPK activates KCNA3. 9 / 9
| 9
sparser
"The closely-related mitogen-activated protein kinase-activated protein kinases MK2 and MK3 are involved in both up- and down-regulation of inflammation in mammals and govern the inflammatory response at different regulatory levels of gene expression and with different kinetics."
23832958
sparser
"Based on structural and functional homology, the MAPKAPKs are divided in four subfamilies: ribosomal S6 kinase (RSK) with the members RSK1-4; mitogen- and stress-activated kinase (MSK) comprising MSK1 and MSK2; MAPK-interacting protein kinase (MNK) including MNK1 and MNK2, and the MAPK-activated protein kinases (MAPKAPK) MK2, MK3 and MK5 [ xref - xref ]."
21575178
sparser
"Those functionally subordinate to p38 include MAPK-activated protein kinases MK2 and MK3 (also called MAPKAP-K2 and MAPKAP-K3), mitogen- and stress-activated kinases MSK1 and MSK2, and MAPK-interacting kinases MNK1 and MNK2."
19740675
sparser
"We demonstrate that the mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) MK2 and MK3 are activated on virus infection and, in their active form, directly interact with the repressor of the inhibitor of PKR p88(rIPK)."
20484669
sparser
"MAPKAPK5/PRAK is a serine/threonine kinase was originally identified based on homology with two other MAP kinase activated kinases, MK2 and MK3 [ xref , xref ]."
26042227
sparser
"Using this assay, we quantitatively evaluate the role of the MAPK-activated protein kinases MK2 and MK3 in fibroblast migration."
19743408
sparser
"This applies to the MAPK-activated protein kinases MK2 and MK3."
19484198
sparser
"MAPK-activated kinases MK2 and MK3 are uniquely activated by p38 MAPK, whereas the mitogen- and stress-activated kinases MSK1 and MSK2 can be activated by either p38 MAPK or ERK."
23028406
sparser
"Downstream substrates for MAPKs are transcription factors (e.g., ATF2, ELK‐1, or c‐Jun), and other protein kinases, such as the MAP kinase‐activated protein kinases MK2 and MK3."
22247330
KCNA3 affects BAX
2 1 | 1 5
KCNA3 binds BAX. 7 / 7
2 1 | 1 4
sparser
"Our results point to a physiologically relevant interaction of Bax with Kv1.3 and further indicate a crucial role of a distinct lysine in determining the proapoptotic character of Bcl2-family proteins."
20885444
biogrid
No evidence text available
20114030
biogrid
No evidence text available
20114030
hprd
No evidence text available
18818304
sparser
"Strongly relating potassium channels with the regulation of apoptosis, an physical interaction between Bax and Kv1.3 was reported in lymphocytes, which appeared as necessary for Bax-induced apoptosis xref ."
22723988
sparser
"We have also shown that Bax binds to the pore of Kv1.3, subsequently resulting in the inhibition of Kv1.3 activity in isolated mitochondria."
22496117
sparser
"To gain insight into the mechanism of Bax-Kv1.3 interaction, we mutated Glu158 of Bcl-x(L) (corresponding to K128 in Bax) to lysine."
20885444
KCNA1 binds KCNA3, KCNA5, and BAX. 1 / 1
| 1
sparser
"Here we report that, like Kv1.3, Kv1.1 and Kv1.5 also interact with Bax."
22856664
P38 affects KCNA3
| 7
P38 activates KCNA3. 7 / 7
| 7
sparser
"MK2 and MK3 possess 75% sequence identity and are directly activated by p38 MAPK [ xref , xref ]."
24705157
sparser
"MK3 is the MAPKAPK that is most structurally related to MK2 and is also directly activated by p38 MAPK [ xref ]."
24705157
sparser
"Whereas MK2 and MK3 are activated by p38 MAPK, MK5 has also been shown to be activated by ERK3 and ERK4."
20214976
sparser
"However, p38 MAPK can also activate MK3 and MK5 [ xref ], suggesting that these protein kinases may also be implicated in stress-induced HSP27 phosphorylation."
21575178
sparser
"MAPK-activated kinases MK2 and MK3 are uniquely activated by p38 MAPK, whereas the mitogen- and stress-activated kinases MSK1 and MSK2 can be activated by either p38 MAPK or ERK."
23028406
sparser
"Using unbiased approaches, we identified Beclin 1 S90 as a key phosphorylation site in starvation-induced autophagy and identified two stress-activated protein kinase signaling pathway family members, the p38 MAPK-activated protein kinases MK2 and MK3, as crucial kinases that mediate Beclin 1 S90 phosphorylation."
25693418
sparser
"That is, the dose-dependent reduction in neuron killing by minocycline corresponded with a reduction in p38 mitogen-activated protein kinase activation in microglia; however, none of the Kv1.3 blockers affected p38 activation."
16079396
Mgt affects KCNA3
| 7
Mgt binds KCNA3.
| 4
KCNA3 binds mgt. 4 / 4
| 4
sparser
"We examine the binding of MgTx to Kv1.3 using molecular dynamics with distance restraint."
25054783
sparser
"We construct the potential of mean force (PMF) profile of the binding of the MgTx-Kv1.3 complex predicted from our simulations."
25054783
sparser
"Acetylation or biotinylation of the amino group reduced binding (10-fold) of MgTX to Kv1.3, suggesting the involvement of the N-terminal amino group in the toxin activity [30] ."
9395089
sparser
"The simulations suggest that MgTx-Lys35 occludes the ion conduction pathway of the channel on the formation of the MgTx-Kv1.3 complex, while Lys28 of the toxin stabilizes the complex by forming an additional salt bridge with Asp449, located just outside of the selectivity filter."
25054783
Mgt inhibits KCNA3.
| 3
Mgt inhibits KCNA3. 3 / 3
| 3
sparser
"Inhibition of mouse Kv1.3 and Kv1.1 by recombinant MgTx and AgTx2."
23300835
sparser
"When unbound MgTx inhibits Kv1.3, a strong shift in activation voltage and a clear loss of voltage dependence is observed in comparison to control solution."
27861889
sparser
"However, both Kv1.2 and Kv1.3 were inhibited by MgTx at this concentration ( xref , Mann-Whitney U, non-parametric paired t -test, p = 0.0013 for Kv1.2, n = 6-7; p = 0.0001 for Kv1.3, n = 16-18)."
27861889
LCK affects KCNA3
| 7
LCK phosphorylates KCNA3.
| 6
LCK phosphorylates KCNA3. 6 / 6
| 6
sparser
"To explain the observed Kv1.3 current decrease of the 5 day-treated Jurkat E6.1 cells by gp160, we hypothesized first that this reduction was due to a p56 lck -dependent phosphorylation of Kv1.3 channels."
9989602
sparser
"To explain the observed Kv1.3 current decrease of the 5 day-treated Jurkat E6.1 cells by gp160, we hypothesized first that this reduction was due to a p56 lck -dependent phosphorylation of Kv1.3 channels."
9989602
sparser
"To explain the observed Kv1.3 current decrease of the 5 day-treated Jurkat E6.1 cells by gp160, we hypothesized first that this reduction was due to a p56 lck -dependent phosphorylation of Kv1.3 channels."
9989602
sparser
"Thus, the reduction of Kv1.3 current is probably not due to p56 lck phosphorylation of Kv1.3 channels."
9989602
sparser
"Thus, the reduction of Kv1.3 current is probably not due to p56 lck phosphorylation of Kv1.3 channels."
9989602
sparser
"Thus, the reduction of Kv1.3 current is probably not due to p56 lck phosphorylation of Kv1.3 channels."
9989602
LCK binds KCNA3.
| 1
KCNA3 binds LCK. 1 / 1
| 1
sparser
"Recent studies reveal that Lck indirectly interacts with Kv1.3 α subunits and plays a key role in acute hypoxia-induced Kv1.3 channel inhibition in T lymphocytes."
23792273
INS affects KCNA3
| 6
INS phosphorylates KCNA3. 6 / 6
| 6
sparser
"Insulin-induced Kv1.3 phosphorylation in the OB (Fadool and Levitan, xref ; Fadool et al., xref ) was lost in DIO mice (Marks et al., xref ) and slices from these mice exhibited loss of insulin modulation of mitral cell excitability, exemplifying a degree of insulin resistance for mitral cell function in the obese state (Fadool et al., xref )."
27242550
sparser
"This would be congruent with our previous findings that insulin-induced phosphorylation of Kv1.3 (Fadool et al., xref , xref ; Marks et al., xref ) and resultant decrease in channel open probability (Fadool et al., xref ) evokes a reduction in anxiety behaviors when intranasally administered to the OB (Marks et al., xref )."
29615878
sparser
"Insulin and the incretin hormone, GLP-1, can phosphorylate Kv1.3 at the plasma membrane, decrease Kv1.3 current and upregulate GLUT4 translocation to the membrane to facilitate glucose metabolism."
27242550
sparser
"Most interestingly, the increase in insulin-induced Kv1.3 phosphorylation via IND was significantly less in the OBs from mice raised on the MHF-diet compared to that from mice maintained on control diets ( xref ) (Student’s t -test, α ≤ 0.05)."
19458242
sparser
"Using intranasal insulin delivery across the cribiform plate, into the olfactory bulb, we demonstrated that animals maintained on a MHF-diet now failed to exhibit an increase in insulin-induced Kv1.3 phosphorylation, developing a degree of insulin resistance at the level of the ion channel ( xref ) ( xref )."
20865378
sparser
"We have previously reported that Kv1.3 channel modulation can be perturbed by adaptor proteins via disruption of src- or insulin-induced Kv1.3 phosphorylation [ xref , xref ]."
19166614
SHPK affects KCNA3
| 5
SHPK binds KCNA3.
| 3
SHPK binds KCNA3. 3 / 3
| 3
sparser
"Therefore, it remains to be determined whether multiple binding modes would be required to describe the binding of ShK to Kv1.3."
26633507
sparser
"Models of D-allo-ShK bound to Kv1.3 show that it can block the pore as effectively as ShK but makes different interactions with the vestibule, some of which are less favorable than for native ShK."
17984097
sparser
"Contrasting the binding modes of ShK and ShK-K-amide ( xref ), it is seen that Arg1 is already involved in binding of ShK to Kv1.3 so the mutation leads to some rearrangement among the contact pairs but their number and quality as measured by the contact distances are preserved."
23063513
SHPK inhibits KCNA3.
| 2
SHPK inhibits KCNA3. 2 / 2
| 2
sparser
"As described previously [ xref , xref ], ShK inhibited Kv1.3 and Kv1.1 channels with similar potencies (IC 50 of 9 ± 2 pM for Kv1.3 and 23 ± 3 pM for Kv1.1)."
23063513
sparser
"Engineered variants of ShK, OsK1 and OdK2 that potently and selectively inhibit Kv1.3 have also been identified [ xref , xref ]."
28107393
MAPK14 affects KCNA3
| 5
MAPK14 activates KCNA3.
| 3
MAPK14 activates KCNA3. 3 / 3
| 3
sparser
"The p38α-activated kinases MK2 and MK3 have previously been implicated in regulating the induction of several cytokines, including IL-10, in macrophages ( xref )."
29229781
sparser
"For example, p38α activates the downstream kinases MK2 and MK3 to promote the production of TNF xref ."
27498693
sparser
"Both ERK1/2 and p38 are able to activate downstream kinases; p38α activates the related kinases MK2 and MK3, whereas ERK1/2 is able to activate RSK1, 2, and 3 ( xref )."
29229781
MAPK14 phosphorylates KCNA3.
| 2
MAPK14 phosphorylates KCNA3. 2 / 2
| 2
sparser
"GST-MK3.2 was poorly phosphorylated by p38alpha and p38beta and not phosphorylated by p38delta and p38gamma."
20570725
sparser
"In vitro, GST-MK3.1 was strongly phosphorylated by p38alpha and p38beta, but a poor substrate for p38delta and p38gamma."
20570725
KCNA3 affects Integrins
| 1 5
Integrins binds KCNA3. 4 / 4
| 1 4
sparser
"Furthermore, our studies of living cells indicate that the β1 integrin–Kv1.3 channel interaction is not static, but rather can be quite dynamic, depending upon the experimental circumstances."
12084773
sparser
"Thus, a direct physical interaction between β1 integrins and Kv1.3 channels may contribute to cell signaling and functions."
12084773
sparser
"Furthermore, Kv1.3 associates to β1 integrins and may thus participate in the adhesion of the T cell to the APC xref ."
22952790
sparser
"Recently, xref have suggested that integrins interact with Kv1.3 channels on lymphocyte membranes."
12084773
Integrins binds KCNA3 and PLAU. 1 / 1
| 1
sparser
"Although it has been demonstrated that integrins interact with both urokinase-type plasminogen activator receptors and Kv1.3, whether or not all three molecules are simultaneously present in the same assembly is not known."
12084773
Pyraclofos affects KCNA3
| 4
Pyraclofos activates KCNA3. 4 / 4
| 4
sparser
"The large-conductance, calcium- and voltage-activated potassium channel, or BK channel, is a conserved target of ethanol."
30158242
sparser
"MacKinnon R: Determination of the subunit stoichiometry of a voltage-activated potassium channel."
9719863
sparser
"The best-studied K + channels that predominately regulate V m in lymphocytes are the voltage-activated K + channel Kv1.3 and the Ca 2+ -activated K + channel KCa3.1 (or KCNN4, IKCa 2+ and SK4)."
22699833
sparser
"AnSSISS2f3-barrelstructure for the voltage-activated potassium channel."
8534803
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide affects KCNA3
| 4
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide inhibits KCNA3. 4 / 4
| 4
sparser
"Because the concentrations of PKA inhibitors, Rp-cAMPS and PKI 5-24, used in this study are sufficiently high to inhibit PKA activity completely, H-89-induced inhibition of Kv1.3 does not result from inhibition of PKA."
11286994
sparser
"Therefore, the characteristics of Kv1.3 inhibition by H-89 are similar to previous findings of open channel block of Kv1.3 by staurosporine in the same cells ."
11286994
sparser
"We report for the first time that H-89 inhibits Kv1.3 channels, a member of the -type K channel subfamily, by a mechanism which is independent of PKA."
11286994
sparser
"We find that H-89 potently inhibits Kv1.3 by a mechanism that is independent of PKA inhibition, and the concentrations required to inhibit Kv1.3 are within the range of those used in physiological experiments."
11286994
KCNA3 affects mgt
| 4
KCNA3 binds mgt. 4 / 4
| 4
sparser
"We examine the binding of MgTx to Kv1.3 using molecular dynamics with distance restraint."
25054783
sparser
"We construct the potential of mean force (PMF) profile of the binding of the MgTx-Kv1.3 complex predicted from our simulations."
25054783
sparser
"Acetylation or biotinylation of the amino group reduced binding (10-fold) of MgTX to Kv1.3, suggesting the involvement of the N-terminal amino group in the toxin activity [30] ."
9395089
sparser
"The simulations suggest that MgTx-Lys35 occludes the ion conduction pathway of the channel on the formation of the MgTx-Kv1.3 complex, while Lys28 of the toxin stabilizes the complex by forming an additional salt bridge with Asp449, located just outside of the selectivity filter."
25054783
KCNA3 affects SHPK
| 3 1
KCNA3 binds SHPK.
| 3
SHPK binds KCNA3. 3 / 3
| 3
sparser
"Therefore, it remains to be determined whether multiple binding modes would be required to describe the binding of ShK to Kv1.3."
26633507
sparser
"Models of D-allo-ShK bound to Kv1.3 show that it can block the pore as effectively as ShK but makes different interactions with the vestibule, some of which are less favorable than for native ShK."
17984097
sparser
"Contrasting the binding modes of ShK and ShK-K-amide ( xref ), it is seen that Arg1 is already involved in binding of ShK to Kv1.3 so the mutation leads to some rearrangement among the contact pairs but their number and quality as measured by the contact distances are preserved."
23063513
KCNA3 inhibits SHPK.
| 1
KCNA3 inhibits SHPK. 1 / 1
| 1
reach
"siRNA knockdown of KCNA3 reversed the inhibitory effects of ShK, rendering GAD65 specific T-cell proliferation and IFN-gamma responses unaffected by ShK (XREF_FIG)."
28248292
KCNA3 affects DLG1
1 1 | 1 1
DLG1 binds KCNA3. 3 / 3
1 1 | 1
biogrid
No evidence text available
9341123
hprd
No evidence text available
7477295
trips
"In addition, we show in vivo association of hDlg with Kv1.3 channel, which was expressed in T lymphocytes as an epitope-tagged protein using a vaccinia virus expression system."
9341123
DLG1 binds DLG4 and KCNA3. 1 / 1
| 1
sparser
"Disruption of the interaction between PSD-95 or SAP97 and Kv1.3 in Jurkat was realized by the expression of a C-terminal truncated Kv1.3, which lacks the binding domain for these proteins, or by the knockdown of the expression of PSD-95 or SAP97 using specific shRNA."
23553419
KCNA3 affects CAV1
4 |
CAV1 binds KCNA3. 4 / 4
4 |
biogrid
No evidence text available
26931497
biogrid
No evidence text available
18218624
biogrid
No evidence text available
18218624
biogrid
No evidence text available
26931497
DLG1 affects KCNA3
1 1 | 1 1
DLG1 binds KCNA3. 3 / 3
1 1 | 1
biogrid
No evidence text available
9341123
hprd
No evidence text available
7477295
trips
"In addition, we show in vivo association of hDlg with Kv1.3 channel, which was expressed in T lymphocytes as an epitope-tagged protein using a vaccinia virus expression system."
9341123
DLG1 binds DLG4 and KCNA3. 1 / 1
| 1
sparser
"Disruption of the interaction between PSD-95 or SAP97 and Kv1.3 in Jurkat was realized by the expression of a C-terminal truncated Kv1.3, which lacks the binding domain for these proteins, or by the knockdown of the expression of PSD-95 or SAP97 using specific shRNA."
23553419
CAV1 affects KCNA3
4 |
CAV1 binds KCNA3. 4 / 4
4 |
biogrid
No evidence text available
26931497
biogrid
No evidence text available
18218624
biogrid
No evidence text available
18218624
biogrid
No evidence text available
26931497
REG3A affects KCNA3
| 2 3
REG3A inhibits KCNA3. 3 / 3
| 2 3
sparser
"PAP-1 inhibits Kv1.3 with an IC 50 of 2 nM ( xref ), has a half-life of 3 hours in rodents, is orally available, brain penetrant and does not exhibit any long-term toxicity in rodents or primates ( xref ; xref ; xref )."
30043400
sparser
"Although acting at different regions of the channel than Bax and MgTx (Cahalan & Chandy, xref ), PAP-1, Psora-4 and clofazimine also inhibit Kv1.3 and induce cytochrome c release and mitochondrial membrane depolarization."
22496117
sparser
"We speculate that Kv1.3KO (or chronic Kv1.3 inhibition), but not acute inhibition of Kv1.3 by PAP-1, may cause a long-lasting change of synaptic release mechanism, which endows the Schaffer collateral-CA1 synapses with resistance to LPS-mediated acute effect on the STP."
30043400
KCNA3 affects cell population proliferation
| 3 3
KCNA3 inhibits cell population proliferation. 2 / 2
| 2
reach
"Additionally, up-regulation of lncRNA kcna3 repressed the proliferation, migration, invasion and tumorigenesis of colon cancer SW620 cells.Furthermore, we observed that YAP1 expression was reduced and its protein stability was decreased when up-regulated lncRNA kcna3 in SW620 cells, using western blotting assay."
30099342
reach
"Taken together, these results reveal that lncRNA kcna3 inhibits cell proliferation and tumorigenesis through down-regulating YAP1 expression.A tremendous advance in lncRNAs research has been acquired over the past decade."
30099342
KCNA3 activates cell population proliferation. 1 / 1
| 3 1
reach
"For example, it has been shown that Kv1.3 (KCNA3) and Kv3.1 (KCNC1) blockade increases neural progenitor cell proliferation [XREF_BIBR]; likewise, induction of H + flux induces regeneration of a complex appendage [XREF_BIBR] and blockade of gap junction mediated signals results in the formation of a complete, properly patterned head in a planarian tail blastema [XREF_BIBR]."
19406249
KCNA3 affects cell growth
| 1 2
KCNA3 inhibits cell growth. 3 / 3
| 1 2
reach
"Up-regulation of lncRNA kcna3 inhibited cell growth, carcinogenesis and promoted cell apoptosis, while up-regulation of YAP1 promoted cell growth, carcinogenesis and inhibited cell apoptosis."
30099342
sparser
"Up-regulation of lncRNA kcna3 inhibited cell growth, carcinogenesis and promoted cell apoptosis, while up-regulation of YAP1 promoted cell growth, carcinogenesis and inhibited cell apoptosis."
30099342
reach
"Results showed that up-regulation of lncRNA kcna3 with Lenti-kcna3 markedly repressed cell growth, migration and invasion, and induced cell apoptosis with the total early and late apoptosis rate rose from (6.2 +/- 1.1)% to (17.5 +/- 2.3)%."
30099342
KCNA3 affects apoptotic process
| 3
KCNA3 activates apoptotic process. 3 / 3
| 3
reach
"Moreover, the repression of cell growth and carcinogenesis and promotion of cell apoptosis induced by Lenti-kcna3 up-regulation were impaired when YAP1 was over-expressed."
30099342
reach
"Up-regulation of lncRNA kcna3 inhibited cell growth, carcinogenesis and promoted cell apoptosis, while up-regulation of YAP1 promoted cell growth, carcinogenesis and inhibited cell apoptosis."
30099342
reach
"Besides, our study demonstrated that cell growth and tumorigesis repression and cell apoptosis promotion mediated by lncRNA kcna3 over-expression were all weakened when up-regulated YAP1, suggesting that lncRNA kcna3 inhibited the progression of CRC through down-regulating YAP1 in CRC.The Hippo pathway is made up of a series of high conserved kinase cascades and they can form a complex, which phosphorylates YAP and facilitates the localization of YAP in the cytoplasm in mammals."
30099342
KCNA3 affects YAP1
| 3
KCNA3 decreases the amount of YAP1.
| 2
KCNA3 decreases the amount of YAP1. 2 / 2
| 2
reach
"Mechanistically, up-regulation of lncRNA kcna3 decreased YAP1 protein expression and accelerated its degradation."
30099342
reach
"These results demonstrate that up-regulation of lncRNA kcna3 reduce YAP1 expression and facilitate its degradation in SW620 cells.Finally, we studied the function of lncRNA kcna3 and YAP1 in the proliferation, apoptosis and tumorigenesis of SW620 and LoVo cells."
30099342
KCNA3 inhibits YAP1.
| 1
KCNA3 inhibits YAP1. 1 / 1
| 1
reach
"And results showed that, compared with the control group, Lenti-kcna3 accelerated the degradation of YAP1 protein while si-kcna3 slowed down it."
30099342
KCNA3 affects Neoplasm Invasiveness
| 3
KCNA3 inhibits Neoplasm Invasiveness. 3 / 3
| 3
reach
"Furthermore, this study showed that lncRNA kcna3 inhibited the growth, migration, invasion and carcinogenesis of CRC through down-regulating YAP1 in CRC, as Fig. 8 shown."
30099342
reach
"Additionally, up-regulation of lncRNA kcna3 repressed the proliferation, migration, invasion and tumorigenesis of colon cancer SW620 cells.Furthermore, we observed that YAP1 expression was reduced and its protein stability was decreased when up-regulated lncRNA kcna3 in SW620 cells, using western blotting assay."
30099342
reach
"Results showed that up-regulation of lncRNA kcna3 with Lenti-kcna3 markedly repressed cell growth, migration and invasion, and induced cell apoptosis with the total early and late apoptosis rate rose from (6.2 +/- 1.1)% to (17.5 +/- 2.3)%."
30099342
KCNA3 affects CRC
| 1 2
KCNA3 inhibits CRC. 3 / 3
| 1 2
sparser
"Furthermore, this study showed that lncRNA kcna3 inhibited the growth, migration, invasion and carcinogenesis of CRC through down-regulating YAP1 in CRC, as Fig. 8 shown."
30099342
reach
"Besides, our study demonstrated that cell growth and tumorigesis repression and cell apoptosis promotion mediated by lncRNA kcna3 over-expression were all weakened when up-regulated YAP1, suggesting that lncRNA kcna3 inhibited the progression of CRC through down-regulating YAP1 in CRC.The Hippo pathway is made up of a series of high conserved kinase cascades and they can form a complex, which phosphorylates YAP and facilitates the localization of YAP in the cytoplasm in mammals."
30099342
reach
"Furthermore, this study showed that lncRNA kcna3 inhibited the growth, migration, invasion and carcinogenesis of CRC through down-regulating YAP1 in CRC, as Fig. 8 shown."
30099342
KCNA3 affects BECN1
| 3
KCNA3 phosphorylates BECN1 on S90. 2 / 2
| 2
sparser
"Given the requirement of the Beclin 1 S90 site for the tumor suppressor activity of Beclin 1, it will be interesting to determine whether the lack of MK3-dependent Beclin 1 S90 phosphorylation contributes to the pathogenesis of small cell lung carcinomas that commonly harbor deletions in MK3 ( xref ) or of other cancers with frequent heterozygous loss of MK3 such as invasive breast carcinomas, ovarian carcinomas, lung adenocarcinomas and lung squamous cell carcinomas ()."
25693418
sparser
"Taken together, these data indicate that MK2 and MK3 directly phosphorylate Beclin 1 S90 in vitro, and that MK2-like kinase activity also mediates starvation-induced Beclin 1 S90 phosphorylation in cultured cells."
25693418
KCNA3 phosphorylates BECN1. 1 / 1
| 1
sparser
"MK2 and MK3 phosphorylate a Beclin 1 peptide spanning S90 in vitro; MK2 and MK3 phosphorylate Beclin 1 immunoprecipitated from cells in vitro; dominant negative MK2 blocks starvation-induced Beclin 1 S90 phosphorylation and constitutively active MK2 induces Beclin 1 S90 starvation during basal conditions; and MEFs from MK2/MK3 knockout mice are deficient in starvation-induced Beclin 1 S90 phosphorylation."
25693418
BDNF affects KCNA3
| 3
BDNF phosphorylates KCNA3. 3 / 3
| 3
sparser
"Grb10 was interestingly able to decrease the total expression of Kv1.3, particularly at the membrane surface, and subsequently eliminated the BDNF-induced phosphorylation of Kv1.3."
19166614
sparser
"nShc formed a direct protein-protein interaction with Kv1.3 that was independent of BDNF-induced phosphorylation of Kv1.3, whereas Grb10 did not complex with Kv1.3 in HEK 293 cells."
19166614
sparser
"The degree of BDNF-induced Kv1.3 phosphorylation in each transfection condition was quantified by densitometry, normalized to that of the Kv1.3 channel transfection alone, and statistically compared in the bar plot of Fig. xref (Student's t -test, arc sine transformation for percentage data, α ≤ 0.05)."
19166614
Tacrolimus (anhydrous) affects KCNA3
| 2
Tacrolimus (anhydrous) inhibits KCNA3. 2 / 2
| 2
sparser
"In this regard, published cell culture experiments point to Kv1.3 as one such target, showing that FK506 inhibited Kv1.3 in a concentration-dependent manner without suppression of calcineurin protein phosphatase activity."
27302680
sparser
"Of particular interest, FK506 inhibited Kv1.3 channels by mechanisms not involving the suppression of calcineurin phosphatase activity, but by a direct interaction with the channel protein ( xref )."
27302680
Copper(2+) affects KCNA3
| 2
Copper(2+) inhibits KCNA3. 2 / 2
| 2
sparser
"Altogether, obtained data suggest that Cu inhibits Kv1.3 channels by a different mechanism than Zn and that Cu and Zn act on different binding sites."
16845233
sparser
"Possible physiological significance of the Cu-induced inhibition of Kv1.3 channels is discussed."
16845233
Ceramide affects KCNA3
| 2
Ceramide phosphorylates KCNA3.
| 1
Ceramide phosphorylates KCNA3. 1 / 1
| 1
sparser
"Here, we demonstrate that ceramide, a lipid metabolite synthesized upon Fas receptor ligation, inhibits n-K+ channel activity and induces a tyrosine phosphorylation of the Kv1.3 protein in Jurkat T lymphocytes."
9207149
Ceramide inhibits KCNA3.
| 1
Ceramide inhibits KCNA3. 1 / 1
| 1
sparser
"The transformation of small rafts into ceramide-enriched membrane platforms is mimicked by addition of exogenous sphingomyelinase or C 16 -ceramide that also inhibit Kv1.3."
12767914
Beta1-integrin affects KCNA3
| 2
KCNA3 binds beta1-integrin. 2 / 2
| 2
reach
"In human T-cells, KCNA3 formed a complex with beta1-integrin, which seems to be implicated in propagation and retardation of migration by activation or inhibition of the channel, respectively [XREF_BIBR], [XREF_BIBR]."
26824610
reach
"In this vein, molecular interactions between Kv1.3 and beta1-integrin, and SAP-97 (synapse associated protein 97) and Kvbeta2 regulatory subunits has been also documented."
21423392
UBTF affects KCNA3
2 | 1
UBTF binds KCNA3. 2 / 2
2 | 1
biogrid
No evidence text available
25829491
biogrid
No evidence text available
25829491
RANGAP1 affects KCNA3
| 2
RANGAP1 inhibits KCNA3. 2 / 2
| 2
sparser
"Direct inhibition of Kv1.3 in T cells by SD and LrB might be the cellular and molecular basis of SD-mediated immunosuppression."
25937895
sparser
"SD and LrB inhibit Kv1.3 in Jurkat T cells."
25937895
Protein Kinase C affects KCNA3
| 2
Protein Kinase C phosphorylates KCNA3. 1 / 1
| 1
sparser
"Cai and Douglass [24] showed that PKC or a PKC-like enzyme could phosphorylate the Kv1.3 proteins, by using anti-Kv1.3 antibodies."
9989602
Protein Kinase C phosphorylates KCNA3 on serine. 1 / 1
| 1
sparser
"Phosphorylation of Kv1.3 on four serine residues by PKA and PKC is known to increase Kv1.3 activity to maintain a negative membrane potential (Chung and Schlichter, xref , xref )."
27242550
NEDD4L affects KCNA3
2 |
KCNA3 binds NEDD4L. 2 / 2
2 |
biogrid
No evidence text available
27146988
biogrid
No evidence text available
27146988
MAPK11 affects KCNA3
| 2
MAPK11 phosphorylates KCNA3. 2 / 2
| 2
sparser
"In vitro, GST-MK3.1 was strongly phosphorylated by p38alpha and p38beta, but a poor substrate for p38delta and p38gamma."
20570725
sparser
"GST-MK3.2 was poorly phosphorylated by p38alpha and p38beta and not phosphorylated by p38delta and p38gamma."
20570725
LEP affects KCNA3
| 2
LEP phosphorylates KCNA3 on threonine. 1 / 1
| 1
sparser
"Because Kv1.3 has been well studied and is known to be a substrate for Tyr phosphorylation by several neuromodulators of MC AP firing frequency (Fadool & Levitan, xref ; Fadool et al . xref ; Tucker & Fadool, xref ; Colley et al . xref ; Fadool et al . xref ; Mast & Fadool, xref ), it would be intriguing to explore whether GLP‐1 stimulation of the OB can phosphorylate Kv1.3 on either Ser or Thr residues or use a cAMP independent mechanism to phosphorylate Kv1.3 on Tyr residues linked to MAPK activation (Egan et al . xref )."
26931093
LEP phosphorylates KCNA3 on serine. 1 / 1
| 1
sparser
"Because Kv1.3 has been well studied and is known to be a substrate for Tyr phosphorylation by several neuromodulators of MC AP firing frequency (Fadool & Levitan, xref ; Fadool et al . xref ; Tucker & Fadool, xref ; Colley et al . xref ; Fadool et al . xref ; Mast & Fadool, xref ), it would be intriguing to explore whether GLP‐1 stimulation of the OB can phosphorylate Kv1.3 on either Ser or Thr residues or use a cAMP independent mechanism to phosphorylate Kv1.3 on Tyr residues linked to MAPK activation (Egan et al . xref )."
26931093
KCNA3 affects potassium(1+)
| 2
KCNA3 activates potassium(1+). 2 / 2
| 2
reach
"Due to its TCR induced expression and previously described role in T cell function XREF_BIBR, we hypothesized that enforced expression of Kcna3 may increase potassium efflux with a resultant increase in intratumoural T cell effector function."
27626381
reach
"When expressed into Xenopus oocytes, HLK3 K+ channel (Kv1-3) induced a slowly inactivating voltage dependent K+ current."
1607023
KCNA3 affects molybdenum atom
| 2
KCNA3 inhibits molybdenum atom. 2 / 2
| 2
sparser
"Biophysical and mo- lecular mechanisms ofShaker potassium channel inactivation."
8038379
sparser
"Biophysical and mo- lecular mechanisms ofShaker potassium channel inactivation."
8218899
KCNA3 affects beta1-integrin
| 2
KCNA3 binds beta1-integrin. 2 / 2
| 2
reach
"In human T-cells, KCNA3 formed a complex with beta1-integrin, which seems to be implicated in propagation and retardation of migration by activation or inhibition of the channel, respectively [XREF_BIBR], [XREF_BIBR]."
26824610
reach
"In this vein, molecular interactions between Kv1.3 and beta1-integrin, and SAP-97 (synapse associated protein 97) and Kvbeta2 regulatory subunits has been also documented."
21423392
KCNA3 affects UBTF
2 | 1
UBTF binds KCNA3. 2 / 2
2 | 1
biogrid
No evidence text available
25829491
biogrid
No evidence text available
25829491
KCNA3 affects SMC arteriogenesis
| 2
KCNA3 activates SMC arteriogenesis. 2 / 2
| 2
eidos
"Together , these data indicate that KV1.3 but not KCa3.1 contributes to SMC proliferation in arteriogenesis ."
32276492
eidos
"From our results we conclude that KV1.3 contributes to SMC proliferation in arteriogenesis , whereas KCa3.1 is more likely to be involved in vasodilation ."
32276492
KCNA3 affects PLA2
| 2
KCNA3 phosphorylates PLA2 on S727. 2 / 2
| 2
sparser
"Finally, several kinases downstream of p38 MAPK , including MSK, MNK, and MK5, but neither MK2 nor MK3 can phosphorylate cytoplasmic phospholipase A2 (cPLA 2 ) at Ser-727 in vitro ."
24705157
sparser
"Finally, several kinases downstream of p38 MAPK , including MSK, MNK, and MK5, but neither MK2 nor MK3 can phosphorylate cytoplasmic phospholipase A2 (cPLA 2 ) at Ser-727 in vitro ."
24705157
KCNA3 affects NEDD4L
2 |
KCNA3 binds NEDD4L. 2 / 2
2 |
biogrid
No evidence text available
27146988
biogrid
No evidence text available
27146988
KCNA3 affects ITGB1BP1
| 2
ITGB1BP1 binds KCNA3. 2 / 2
| 2
sparser
"Although verapamil per se is not likely to be broadly used in managing disease, the identification of a molecular pathway contributing to its action, such as the control of β1-integrin-to-Kv1.3 channel interactions, may lead to more effective therapeutic approaches."
12084773
sparser
"The formation of β1-integrin–Kv1.3 channel supramolecular proximity complexes may be particularly important in view of the reduced in vitro invasiveness and the small, but significant reduction in in vivo metastasis found using verapamil ( xref ; xref ; xref ; xref )."
12084773
KCNA3 affects HCLS1
1 | 1
HCLS1 binds KCNA3. 2 / 2
1 | 1
sparser
"In T-lymphocytes, the interaction between HS1 (the cortactin homologue) and Kv1.3 occurs at the immune synapse and requires the channel's C-terminal domain."
25739456
biogrid
No evidence text available
25739456
KCNA3 affects DEFB4A
2 |
DEFB4A binds KCNA3. 2 / 2
2 |
biogrid
No evidence text available
25944908
biogrid
No evidence text available
25944908
KCNA3 affects CD40LG
| 2
KCNA3 inhibits CD40LG. 2 / 2
| 2
sparser
"The inhibition of CD40L by Kv1.3-NPs is consistent with studies showing that CD40L increased expression in SLE T cells is reduced by suppression of Ca 2+ influx with inhibitors such as cyclosporine, especially when they are added at the early stages of stimulation [ xref , xref , xref , xref ]."
26994905
sparser
"The inhibition of CD40L by Kv1.3-NPs is consistent with studies showing that CD40L increased expression in SLE T cells is reduced by suppression of Ca 2+ influx with inhibitors such as cyclosporine, especially when they are added at the early stages of stimulation [1,6,7,34] ."
26994905
ITGB1BP1 affects KCNA3
| 2
ITGB1BP1 binds KCNA3. 2 / 2
| 2
sparser
"Although verapamil per se is not likely to be broadly used in managing disease, the identification of a molecular pathway contributing to its action, such as the control of β1-integrin-to-Kv1.3 channel interactions, may lead to more effective therapeutic approaches."
12084773
sparser
"The formation of β1-integrin–Kv1.3 channel supramolecular proximity complexes may be particularly important in view of the reduced in vitro invasiveness and the small, but significant reduction in in vivo metastasis found using verapamil ( xref ; xref ; xref ; xref )."
12084773
INSR affects KCNA3
| 2
INSR phosphorylates KCNA3.
| 1
INSR phosphorylates KCNA3. 1 / 1
| 1
sparser
"In order to demonstrate that the insulin receptor kinase phosphorylates Kv1.3 in situ , ten anesthetized animals (5 hormone and 5 PBS vehicle) received intranasal delivery (IND) as described in the Materials and Methods."
19458242
INSR binds KCNA3.
| 1
DLG4 binds INSR and KCNA3. 1 / 1
| 1
sparser
"Thus, insulin IND-treatment evokes activation of IR in situ and enhances the scaffolding association of Kv1.3, IR, and PSD-95 protein complexes."
19458242
HCLS1 affects KCNA3
1 | 1
HCLS1 binds KCNA3. 2 / 2
1 | 1
sparser
"In T-lymphocytes, the interaction between HS1 (the cortactin homologue) and Kv1.3 occurs at the immune synapse and requires the channel's C-terminal domain."
25739456
biogrid
No evidence text available
25739456
EGFR affects KCNA3
| 2
EGFR binds KCNA3.
| 1
EGFR binds KCNA3. 1 / 1
| 1
sparser
"Moreover, these experiments strongly reinforce that EGFR does not physically interact with Kv1.3."
26542799
EGFR activates KCNA3.
| 1
EGFR activates KCNA3. 1 / 1
| 1
sparser
"This suggests that EGFR activation and down-regulation of Kv1.3 acts synergistically to promote NSC proliferation and migration."
26542799
DEFB4A affects KCNA3
2 |
DEFB4A binds KCNA3. 2 / 2
2 |
biogrid
No evidence text available
25944908
biogrid
No evidence text available
25944908
Toxin affects KCNA3
| 1
Toxin inhibits KCNA3. 1 / 1
| 1
sparser
"Voltage clamp studies on various ion channels indicated that the toxin inhibits the vertebrate K+ channels Kv1.1 and Kv1.3 but not Kv1.2."
12893060
Titanium atom affects KCNA3
| 1
Titanium atom inhibits KCNA3. 1 / 1
| 1
sparser
"3 +217 +671 +866 Ti Si S2 S3 S4 SS S6NH2 -- -- COOHC:N+217 TI Si671 Ti Si S2- +866 FIGURE 7 Fractional inhibition of Kv1.3 conductance in CTLL-2 by truncated DNAsequences."
7711236
Sirolimus affects KCNA3
| 1
Sirolimus activates KCNA3. 1 / 1
| 1
reach
"To examine the role of these pathways in tumor cell growth and metastatic ability, we measured cell growth in OIP5 expressing HLK3 cells treated with the mTORC1 inhibitor rapamycin (RPM, 100 nM) or the beta-catenin inhibitor cardamonin (CDM, 10 muM)."
28184024
SiRNA treatment affects KCNA3
| 1
SiRNA treatment inhibits KCNA3. 1 / 1
| 1
eidos
"Our data are in line with results from Cidad et al ., who demonstrated an inhibition of femoral artery SMC proliferation when Kv1.3 was blocked pharmacologically with PAP-1 or with Margatoxin or when Kv1.3 was knocked down by siRNA treatment [ 22 ] ."
32276492
Potassium(1+) affects KCNA3
| 1
Potassium(1+) activates KCNA3. 1 / 1
| 1
sparser
"The T-lymphocytes Kv1.3 potassium channel and IKCa1 potassium channel current densities are higher in hypertensive patients in Xinjiang Kazakh suggesting a potential role of Kv1.3 and IKCa1 potassium channels activation in the pathophysiology of hypertension."
24524604
Nystatin affects KCNA3
| 1
Nystatin inhibits KCNA3. 1 / 1
| 1
sparser
"Our results indicate that nystatin can specifically inhibit Kv1.3 channels when applied intracellularly and that this effect cannot be explained by non-specific interactions of the drug with the membrane."
8938720
MTORC2 affects KCNA3
| 1
MTORC2 activates KCNA3. 1 / 1
| 1
sparser
"A number of elegant in vitro and in vivo studies using cell systems and genetically-modified mice have revealed mechanisms underlying activation of the epithelial sodium channel (ENaC) and the renal outer medullary potassium channel (ROMK) by mTORC2."
29846113
Lipopolysaccharide affects KCNA3
| 1
Lipopolysaccharide activates KCNA3. 1 / 1
| 1
reach
"LPS and I+T both increased several Ca 2+ -related molecules (Orai3, Stim1, Trpm7), and K + channels and their regulators (Calm1, Kcna3, Kcnj2, Mtmr6, Rest)."
30087595
Hlb affects KCNA3
| 1
Hlb inhibits KCNA3. 1 / 1
| 1
sparser
"The transformation of small rafts into ceramide-enriched membrane platforms is mimicked by addition of exogenous sphingomyelinase or C 16 -ceramide that also inhibit Kv1.3."
12767914
Flavonoid affects KCNA3
| 1
Flavonoid inhibits KCNA3. 1 / 1
| 1
sparser
"The estimated value of the half-blocking concentration (EC 50 ) was about 5.76 µM. Among non-prenylated flavonoids, acacetin and chrysin inhibited Kv1.3 channels in Jurkat T cells when applied at the concentration of 30 µM, whereas baicalein, wogonin, and luteolin were ineffective at this concentration."
30187077
Diphosphate(4-) affects KCNA3
| 1
Diphosphate(4-) activates KCNA3. 1 / 1
| 1
sparser
"Allard, B. and Lazdunski, M. (1992) Nucleotide diphosphates activate the ATP-sensitive potassium channel in mouse skeletal muscle."
7716183
Coumarins affects KCNA3
| 1
Coumarins inhibits KCNA3. 1 / 1
| 1
sparser
"While 4-phenoxybutoxy-substituted quinolines, quinazolines and phenanthrenes were inactive, 4-phenoxybutoxy-substituted quinolinones, furoquinolines, coumarins or furochromones inhibited Kv1.3 with IC(50)s of 150 nM to 10 microM in whole-cell patch-clamp experiments."
19056148
Concanavalin A affects KCNA3
| 1
Concanavalin A decreases the amount of KCNA3. 1 / 1
| 1
reach
"Mitogenic concentrations of concanavalin A induced a time dependent decrease in HGK5 mRNA levels, suggesting that previously observed increases in potassium current density following concanavalin A treatment of human T lymphocytes are not due to increased transcriptional activity of the type n potassium channel gene."
1547020
V-SRC affects KCNA3
| 1
V-SRC phosphorylates KCNA3. 1 / 1
| 1
sparser
"In HEK 293 cells, co-expression of Kv1.3 plus v-Src with Grb10 causes a decrease in v-Src-induced Kv1.3 tyrosine phosphorylation and a reversal of v-Src-induced Kv1.3 current suppression, increase in inactivation time constant (tau(inact)), and disruption of cumulative inactivation properties."
11812778
TNF affects KCNA3
| 1
TNF activates KCNA3. 1 / 1
| 1
sparser
"Tumor necrosis factor-alpha-induced activation of macrophages increased Kv1.3 with no changes in Kv."
17038323
TGFB1 affects KCNA3
| 1
TGFB1 activates KCNA3. 1 / 1
| 1
reach
"TGFbeta1 increased Kcna3, Kcna5 and Rest in both species; Kcnn4, Orai3 and Trpm7 in rat; and Kcnn3 in mouse."
29780305
TFRC affects KCNA3
1 |
TFRC binds KCNA3. 1 / 1
1 |
biogrid
No evidence text available
18218624
TEA affects KCNA3
| 1
KCNA3 binds TEA. 1 / 1
| 1
sparser
"This means that melatonin and TEA do not bind independently to Kv1.3."
11222291
SP1 affects KCNA3
| 1
SP1 binds KCNA3. 1 / 1
| 1
sparser
"Chromatin immunoprecipitation assay reveals that Sp1 transcription factor is directly bound to the promoter region of the Kv1.3 gene, and the Sp1 regulates Kv1.3 expression in the nucleus of A549 cells."
25829491
SLC5A3 affects KCNA3
| 1
SLC5A3 binds KCNA3. 1 / 1
| 1
sparser
"Observations that support the inositol depletion hypothesis include the following: (i) therapeutically relevant Li concentrations could directly inhibit purified IMPase from different sources; xref (ii) Li reduced brain inositol levels xref and elevated inositol monophosphate (IP 1 ), the substrate of IMPase, in rat cortex; xref , xref (iii) Li administration reduced sodium- myo -inositol transporter 1 (SMIT1) messenger RNA (mRNA) levels and lowered inositol uptake in astrocyte cultures; xref , xref , xref , xref (iv) studies demonstrated Li inhibition of IMPase and elevated IP 1 levels in rat cortex slices; xref (v) some cellular and behavioral effects of Li such as increasing growth cone area, xref enhancing autophagy, xref suppression of rearing in rats xref , xref and hypersensitivity to pilocarpine-induced seizures were reversed by inositol; xref , xref (vi) reduced brain inositol levels and increased IP 1 levels have been reported in BPD patients treated chronically or acutely with Li compared with healthy controls; xref , xref (vii) Li treatment of BPD patients reduced phosphatidylinositol bisphosphate (PIP 2 ) levels in their platelet membranes; xref and (viii) Abbott et al. xref found that SMIT1 and potassium channel subunits formed complexes and reciprocally regulated each other in the choroid plexus epithelium affecting neuronal excitability."
27922641
SLA affects KCNA3
| 1
SLA binds KCNA3. 1 / 1
| 1
sparser
"In particular, it has been shown that Src-like tyrosine kinases, e.g. p56lck, are also present in membrane platforms [18–20] and the fusion of rafts in stimulated cells may result in close proximity of Kv1.3 to or even association of Kv1.3 with Src-like tyrosine kinases [26] ."
12767914
SIGMAR1 affects KCNA3
| 1
KCNA3 binds SIGMAR1. 1 / 1
| 1
sparser
"We also explored the protein domains of Kv1.3 necessary for protein:protein interaction between Kv1.3 and Sigma1R through co-immunoprecipitation studies."
22433979
SEC24A affects KCNA3
| 1
SEC24A binds KCNA3. 1 / 1
| 1
sparser
"Third, we show in vitro the association of recombinantly expressed Kv1.3 and Sec24a proteins."
26156069
PMAIP1 affects KCNA3
| 1
PMAIP1 ubiquitinates KCNA3. 1 / 1
| 1
sparser
"PMA triggered a notable PKC-dependent ubiquitination of Kv1.3, which was hampered by BIM ( xref )."
28186199
PLA2G1B affects KCNA3
| 1
PLA2G1B activates KCNA3. 1 / 1
| 1
sparser
"The studies of xref demonstrated that the hyperosmotic stress activate a mitochondrial PLA2 which in turn activate UCP and potassium channel to control ROS generation ( xref )."
26904045
PLA2 affects KCNA3
| 1
PLA2 activates KCNA3. 1 / 1
| 1
sparser
"The studies of xref demonstrated that the hyperosmotic stress activate a mitochondrial PLA2 which in turn activate UCP and potassium channel to control ROS generation ( xref )."
26904045
PKC affects KCNA3
| 1
PKC ubiquitinates KCNA3. 1 / 1
| 1
sparser
"PMA triggered a notable PKC-dependent ubiquitination of Kv1.3, which was hampered by BIM ( xref )."
28186199
PKA affects KCNA3
| 1
PKA phosphorylates KCNA3 on serine. 1 / 1
| 1
sparser
"Phosphorylation of Kv1.3 on four serine residues by PKA and PKC is known to increase Kv1.3 activity to maintain a negative membrane potential (Chung and Schlichter, xref , xref )."
27242550
PHY1 affects KCNA3
| 1
KCNA3 binds PHY1. 1 / 1
| 1
sparser
"Protein kinase activity closely associated with a reconstituted calcium-activated potassium channel."
7518702
PAG1 affects KCNA3
| 1
PAG1 binds KCNA3. 1 / 1
| 1
sparser
"We detected differential methylation of multiple CpG sites clustered in the ERHV-3 , DMNBP , KCNA3 , PAG1 , and C11orf52 gene regions that were associated with increased risk of relapse in patients with the t(12;21) translocation treated according to standard risk (SR) therapy."
24063430
Ogd affects KCNA3
| 1
Ogd phosphorylates KCNA3. 1 / 1
| 1
sparser
"Biochemical analysis showed that OGD increased the tyrosine phosphorylation of native Kv1.3 protein, which was alleviated by PTK inhibitors or reactive oxygen species (ROS) scavengers."
10886336
Nanoparticles affects KCNA3
| 1
Nanoparticles inhibits KCNA3. 1 / 1
| 1
sparser
"In the present manuscript we have evaluated the consequences of Kv1.3 channel inhibition by Kv1.3-NPs on the downstream effects of Ca 2+ influx in activating T cells: NFAT translocation, expression of CD40L and production of cytokines."
26994905
NRPS3 affects KCNA3
| 1
KCNA3 binds NRPS3. 1 / 1
| 1
sparser
"For R24 it is known that it interacts with the SK2 G348 homologue of Kv1.3 D386 of another channel monomer on the other side of the vestibule ( Aiyar et al., 1995 )."
15208028
NEDD4 affects KCNA3
| 1
NEDD4 ubiquitinates KCNA3. 1 / 1
| 1
sparser
"We further demonstrated that this process requires direct ubiquitination of Kv1.3 by the E3 ubiquitin ligase Nedd4-2."
28186199
NCIT:C48966 affects KCNA3
| 1
KCNA3 binds NCIT:C48966. 1 / 1
| 1
sparser
"It was recently reported that VGKC complex autoantibodies detected by radioimmunoprecipitation assays generally do not bind to VGKC channel proteins per se, but they bind instead to synaptic and axonal neuronal proteins that coprecipitate with detergent-solubilized VGKCs. xref , xref The principal autoantigens defined most commonly were the leucine-rich glioma-inactivated protein 1 (LGI1) in the central nervous system and contactin-associated protein-like2 (CASPR2, which associates with TAG1, PDZ, and the ankyrin-spectrin protein) in both the peripheral and central nervous system. xref , xref Contactin-associated protein-like 2 IgG was reported to associate with peripheral presentations, xref , xref poor prognosis, and risk for tumor, xref and LGI1 IgG with limbic encephalitis and better prognosis. xref , xref To our knowledge, the clinical associations of VGKC complex IgG and of LGI1 and CASPR2 autoantibody subspecificities to date have been reported from investigations involving patients with syndromic presentations of limbic encephalitis, Morvan syndrome, or neuromyotonia."
23407760
MMP affects KCNA3
| 1
MMP binds KCNA3. 1 / 1
| 1
sparser
"Considering also an in trans mechanism, we examined the association of melanoma MMP-23 and melanoma Kv1.3 expression."
25491880
MBD3 affects KCNA3
| 1
MBD3 inhibits KCNA3. 1 / 1
| 1
sparser
"However, the pharmacological profiles indicated that the recombinant mBD3 (rmBD3) weakly inhibited the mouse and human Kv1.3 channels."
29925780
MAPKAPK3 affects KCNA3
| 1
MAPKAPK3 inhibits KCNA3. 1 / 1
| 1
sparser
"MK5 is closely related to MK2 and MK3, and noroxoaconitine inhibited MK3- and MK5- but not MK2-mediated phosphorylation of the common substrate Hsp27."
20640477
MAPKAPK2 affects KCNA3
| 1
MAPKAPK2 inhibits KCNA3. 1 / 1
| 1
sparser
"MK5 is closely related to MK2 and MK3, and noroxoaconitine inhibited MK3- and MK5- but not MK2-mediated phosphorylation of the common substrate Hsp27."
20640477
Ktx-Sp2 affects KCNA3
| 1
Ktx-Sp2 inhibits KCNA3. 1 / 1
| 1
sparser
"Ktx-Sp2 inhibit endogenous Kv1.3 in Jurkat T cells."
31890149
KIF5B affects KCNA3
| 1
KCNA3 binds KIF5B. 1 / 1
| 1
sparser
"We have three pieces of evidence to suggest that the T1 domain also mediates interaction between Kv1 channels and Kif5B: Addition of the T1 domain to a heterologous protein, TfR, is sufficient to cause the resulting fusion protein, TfRT1, to colocalize with Kif5B. Also, the T1 domain is necessary for interaction of Kv1.3 with Kif5B in a coimmunoprecipitation assay."
17241275
KCNE4 subunits affects KCNA3
| 1
KCNE4 subunits activates KCNA3. 1 / 1
| 1
eidos
"The number of KCNE4 subunits that can interact and modulate Kv1.3 is unknown ."
32370164
KCNA3 affects transport
| 1
KCNA3 inhibits transport. 1 / 1
| 1
sparser
"Extracellular Zn 2+ binds to Kv1.3 inhibiting the transport of K + ions through the channel ( xref , xref )."
28553273
KCNA3 affects translocation
| 1
KCNA3 inhibits translocation. 1 / 1
| 1
sparser
"Further analysis of downstream signaling events involved in the transcriptional regulation of IFNβ gene expression suggests that, in the absence of MK2, MK3 impairs interferon regulatory factor 3 protein expression and activation and inhibits nuclear translocation of p65."
21586572
KCNA3 affects signalling pathways
| 1
KCNA3 activates signalling pathways. 1 / 1
| 1
sparser
"Collectively, these data indicate that membrane-permeant Kv1.3 inhibitors activate typical intrinsic apoptotic signalling pathways, and suggest that this action is achieved by specifically targeting mitochondrial Kv1.3."
22496117
KCNA3 affects response
| 1
KCNA3 activates response. 1 / 1
| 1
sparser
"In further support of activation of a senescence-associated response by MK3, TIG3/ MK3 WT OE cells displayed enlarged, flat-cell morphology ( xref )."
25853770
KCNA3 affects ion channel, and kcsA
| 1
KCNA3 binds kcsA and ion channel. 1 / 1
| 1
sparser
"The control fiber tip was dipped in 86 nM ShK and no response was observed ( xref ), which confirms that the oscillation amplitude change shown in xref was due to the specific binding of ShK to the KcsA-Kv1.3 ion channel proteins."
26752355
KCNA3 affects immune responses
| 1
KCNA3 inhibits immune responses. 1 / 1
| 1
sparser
"Koo GC, Blake JT, Talento A, Nguyen M, Lin S, Sirotina A, Shah K, Mulvany K, Hora D Jr, Cunningham P et al: Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo."
9425667
KCNA3 affects glucose
| 1
KCNA3 inhibits glucose. 1 / 1
| 1
reach
"These results, together with reduced liver glucose uptake mediated by DIO2 down-regulation and KCNA3 up-regulation, led us to believe that liver glucose levels were sufficiently high to meet the host 's energy demands."
22272335
KCNA3 affects cytochrome P450
| 1
KCNA3 activates cytochrome P450. 1 / 1
| 1
sparser
"Interestingly, the dilation mechanisms involving cyclooxygenase, guanylyl cyclase, cytochrome-P450 monooxygenase, and potassium channel activation are not affected by H 2 O 2 [ xref ]."
23565508
KCNA3 affects activation
| 1
KCNA3 inhibits activation. 1 / 1
| 1
sparser
"Blocking Kv1.3 inhibits T EM cell activation and attenuates inflammation in autoimmunity, and as such, Kv1.3 has emerged as a promising target for the treatment of T EM cell-mediated autoimmune diseases."
28389388
KCNA3 affects ZFP36
| 1
KCNA3 phosphorylates ZFP36. 1 / 1
| 1
sparser
"MK2 and MK3 also phosphorylate serum-response factor and mRNA binding proteins tristetraprolin (TTP) to mediate de novo transcription of TTP and stabilize the transcription of various inflammatory cytokines, respectively [ 11 , 21 ]."
30205157
KCNA3 affects TFRC
1 |
TFRC binds KCNA3. 1 / 1
1 |
biogrid
No evidence text available
18218624
KCNA3 affects TEA
| 1
KCNA3 binds TEA. 1 / 1
| 1
sparser
"This means that melatonin and TEA do not bind independently to Kv1.3."
11222291
KCNA3 affects TACR1, and kcsA
| 1
TACR1 binds KCNA3 and kcsA. 1 / 1
| 1
sparser
"Although the SPR and BSI studies both showed sub-nanomolar interaction between KcsA-Kv1.3 and its peptide inhibitors, the affinities for both peptides appeared to be 4–5 fold weaker by BSI than the values determined by SPR."
26074010
KCNA3 affects Sodium_channels, Voltage_gated_ion_channels, and ion channel
| 1
Sodium_channels binds Voltage_gated_ion_channels, KCNA3, and ion channel. 1 / 1
| 1
sparser
"By comparing the binding of the C 84 fullerene derivative to two membrane ion channels, the voltage-gated potassium channel Kv1.3 and the bacterial voltage-gated sodium channel Na v Ab, we are able to demonstrate its specificity to Na v Ab."
23855749
KCNA3 affects SW640
| 1
KCNA3 inhibits SW640. 1 / 1
| 1
reach
"Moreover, compared with the normal colon cell line CCD-18Co, the mRNA level of lncRNA kcna3 was decreased in CRC cell lines SW640, LoVo, SW480 and T84."
30099342
KCNA3 affects STAT1
| 1
KCNA3 phosphorylates STAT1 on S727. 1 / 1
| 1
sparser
"Our observations support the early regulation of STAT1 S727 phosphorylation by Kv1.3 channels, a signaling event that can result from direct LPS-TLR signaling mediated through p38 MAP kinase activity as well as by IFNγ receptor activation by paracrine or autocrine IFNγ [ xref ]."
28651603
KCNA3 affects SRC
| 1
SRC binds KCNA3. 1 / 1
| 1
sparser
"This interaction may be facilitated by a multiprotein complex because, in cultured microglia, the endogenous Kv1.3 and src proteins both bind to the scaffolding protein, post-synaptic density protein 95 (PSD-95)."
10886336
KCNA3 affects SP1
| 1
SP1 binds KCNA3. 1 / 1
| 1
sparser
"Chromatin immunoprecipitation assay reveals that Sp1 transcription factor is directly bound to the promoter region of the Kv1.3 gene, and the Sp1 regulates Kv1.3 expression in the nucleus of A549 cells."
25829491
KCNA3 affects SLC5A3
| 1
SLC5A3 binds KCNA3. 1 / 1
| 1
sparser
"Observations that support the inositol depletion hypothesis include the following: (i) therapeutically relevant Li concentrations could directly inhibit purified IMPase from different sources; xref (ii) Li reduced brain inositol levels xref and elevated inositol monophosphate (IP 1 ), the substrate of IMPase, in rat cortex; xref , xref (iii) Li administration reduced sodium- myo -inositol transporter 1 (SMIT1) messenger RNA (mRNA) levels and lowered inositol uptake in astrocyte cultures; xref , xref , xref , xref (iv) studies demonstrated Li inhibition of IMPase and elevated IP 1 levels in rat cortex slices; xref (v) some cellular and behavioral effects of Li such as increasing growth cone area, xref enhancing autophagy, xref suppression of rearing in rats xref , xref and hypersensitivity to pilocarpine-induced seizures were reversed by inositol; xref , xref (vi) reduced brain inositol levels and increased IP 1 levels have been reported in BPD patients treated chronically or acutely with Li compared with healthy controls; xref , xref (vii) Li treatment of BPD patients reduced phosphatidylinositol bisphosphate (PIP 2 ) levels in their platelet membranes; xref and (viii) Abbott et al. xref found that SMIT1 and potassium channel subunits formed complexes and reciprocally regulated each other in the choroid plexus epithelium affecting neuronal excitability."
27922641
KCNA3 affects SLA
| 1
SLA binds KCNA3. 1 / 1
| 1
sparser
"In particular, it has been shown that Src-like tyrosine kinases, e.g. p56lck, are also present in membrane platforms [18–20] and the fusion of rafts in stimulated cells may result in close proximity of Kv1.3 to or even association of Kv1.3 with Src-like tyrosine kinases [26] ."
12767914
KCNA3 affects SIGMAR1
| 1
KCNA3 binds SIGMAR1. 1 / 1
| 1
sparser
"We also explored the protein domains of Kv1.3 necessary for protein:protein interaction between Kv1.3 and Sigma1R through co-immunoprecipitation studies."
22433979
KCNA3 affects SEC24A
| 1
SEC24A binds KCNA3. 1 / 1
| 1
sparser
"Third, we show in vitro the association of recombinantly expressed Kv1.3 and Sec24a proteins."
26156069
KCNA3 affects RTN4
| 1
KCNA3 phosphorylates RTN4 on S107. 1 / 1
| 1
sparser
"For example, Nogo-B is phosphorylated at Serine-107 by MK2 or MK3, but not by other kinases that are activated by p38 [ xref ]."
22024359
KCNA3 affects RSK
| 1
KCNA3 activates RSK. 1 / 1
| 1
sparser
"Although there is a specific interaction between ERKs and RSKs via the CD-LM-interaction in many cell types, an ERK-independent but p38α-dependent activation of RSK by MK2 and MK3 has been described in dendritic cells."
26779481
KCNA3 affects RPS6KA5
| 1
KCNA3 activates RPS6KA5. 1 / 1
| 1
sparser
"More surprising, however, was the disparate regulation of the activation (phosphorylation) of MNK1 and MSK1 by MK2 and/or MK3 (cf. xref B, C), since both MNK1 and MSK1 are direct substrates of p38 MAPK."
23372691
KCNA3 affects PHY1
| 1
KCNA3 binds PHY1. 1 / 1
| 1
sparser
"Protein kinase activity closely associated with a reconstituted calcium-activated potassium channel."
7518702
KCNA3 affects PDGFR-beta Mouse Primary Artery SMCs Vitro Arteriogenesis Vivo Receptor tyrosine kinases such FGFR-1 PDGFR-beta are described relevance SMC
| 1
KCNA3 activates PDGFR-beta Mouse Primary Artery SMCs Vitro Arteriogenesis Vivo Receptor tyrosine kinases such FGFR-1 PDGFR-beta are described relevance SMC. 1 / 1
| 1
eidos
"KV1.3 Blockade Repressed the Expression of FGFR-1 , PDGFR-beta , and Egr1 in Mouse Primary Artery SMCs In Vitro and During Arteriogenesis In Vivo Receptor tyrosine kinases such as FGFR-1 and PDGFR-beta are well described for their relevance in SMC proliferation ."
32276492
KCNA3 affects PAG1
| 1
PAG1 binds KCNA3. 1 / 1
| 1
sparser
"We detected differential methylation of multiple CpG sites clustered in the ERHV-3 , DMNBP , KCNA3 , PAG1 , and C11orf52 gene regions that were associated with increased risk of relapse in patients with the t(12;21) translocation treated according to standard risk (SR) therapy."
24063430
KCNA3 affects Neuralgia
| 1
KCNA3 activates Neuralgia. 1 / 1
| 1
reach
"Kcna3 antisense expression increased after peripheral nerve injury, increased neuronal excitability, and when overexpressed induced NP pain symptoms, a remarkable effect for a single lncRNA."
24904634
KCNA3 affects NUP214
| 1
KCNA3 phosphorylates NUP214 on serine. 1 / 1
| 1
sparser
"This protein can be phosphorylated on serine residues 15, 78 and 82 by MK2, MK3 and MK5, although with different stoichiometry and kinetics and under different conditions [ xref , xref , xref , xref ]."
24705157
KCNA3 affects NRPS3
| 1
KCNA3 binds NRPS3. 1 / 1
| 1
sparser
"For R24 it is known that it interacts with the SK2 G348 homologue of Kv1.3 D386 of another channel monomer on the other side of the vestibule ( Aiyar et al., 1995 )."
15208028
KCNA3 affects NME2
| 1
KCNA3 activates NME2. 1 / 1
| 1
reach
"HLK3 hepatocytes overexpressing Nm23H2 have elevated expressions of c-Myc and cyclin D1, and produced tumors in athymic mice."
25748386
KCNA3 affects NCIT:C48966
| 1
KCNA3 binds NCIT:C48966. 1 / 1
| 1
sparser
"It was recently reported that VGKC complex autoantibodies detected by radioimmunoprecipitation assays generally do not bind to VGKC channel proteins per se, but they bind instead to synaptic and axonal neuronal proteins that coprecipitate with detergent-solubilized VGKCs. xref , xref The principal autoantigens defined most commonly were the leucine-rich glioma-inactivated protein 1 (LGI1) in the central nervous system and contactin-associated protein-like2 (CASPR2, which associates with TAG1, PDZ, and the ankyrin-spectrin protein) in both the peripheral and central nervous system. xref , xref Contactin-associated protein-like 2 IgG was reported to associate with peripheral presentations, xref , xref poor prognosis, and risk for tumor, xref and LGI1 IgG with limbic encephalitis and better prognosis. xref , xref To our knowledge, the clinical associations of VGKC complex IgG and of LGI1 and CASPR2 autoantibody subspecificities to date have been reported from investigations involving patients with syndromic presentations of limbic encephalitis, Morvan syndrome, or neuromyotonia."
23407760
KCNA3 affects MMP
| 1
MMP binds KCNA3. 1 / 1
| 1
sparser
"Considering also an in trans mechanism, we examined the association of melanoma MMP-23 and melanoma Kv1.3 expression."
25491880
KCNA3 affects MKNK1
| 1
KCNA3 activates MKNK1. 1 / 1
| 1
sparser
"More surprising, however, was the disparate regulation of the activation (phosphorylation) of MNK1 and MSK1 by MK2 and/or MK3 (cf. xref B, C), since both MNK1 and MSK1 are direct substrates of p38 MAPK."
23372691
KCNA3 affects MAPKAPK5
| 1
KCNA3 inhibits MAPKAPK5. 1 / 1
| 1
sparser
"MK5 is closely related to MK2 and MK3, and noroxoaconitine inhibited MK3- and MK5- but not MK2-mediated phosphorylation of the common substrate Hsp27."
20640477
KCNA3 affects MAPKAPK3
| 1
KCNA3 inhibits MAPKAPK3. 1 / 1
| 1
sparser
"MK5 is closely related to MK2 and MK3, and noroxoaconitine inhibited MK3- and MK5- but not MK2-mediated phosphorylation of the common substrate Hsp27."
20640477
KCNA3 affects LXR
| 1
KCNA3 inhibits LXR. 1 / 1
| 1
sparser
"As predicted by our microglial transcriptional framework, we also found that promotion of anti-inflammatory DAM and inhibition of pro-inflammatory DAM were achievable via LXR agonism and Kv1.3 channel inhibition."
29784049
KCNA3 affects LEP
| 1
KCNA3 phosphorylates LEP. 1 / 1
| 1
sparser
"Insulin-induced Kv1.3 phosphorylation in the OB (Fadool and Levitan, xref ; Fadool et al., xref ) was lost in DIO mice (Marks et al., xref ) and slices from these mice exhibited loss of insulin modulation of mitral cell excitability, exemplifying a degree of insulin resistance for mitral cell function in the obese state (Fadool et al., xref )."
27242550
KCNA3 affects LCK
| 1
KCNA3 binds LCK. 1 / 1
| 1
sparser
"Recent studies reveal that Lck indirectly interacts with Kv1.3 α subunits and plays a key role in acute hypoxia-induced Kv1.3 channel inhibition in T lymphocytes."
23792273
KCNA3 affects KIF5B
| 1
KCNA3 binds KIF5B. 1 / 1
| 1
sparser
"We have three pieces of evidence to suggest that the T1 domain also mediates interaction between Kv1 channels and Kif5B: Addition of the T1 domain to a heterologous protein, TfR, is sufficient to cause the resulting fusion protein, TfRT1, to colocalize with Kif5B. Also, the T1 domain is necessary for interaction of Kv1.3 with Kif5B in a coimmunoprecipitation assay."
17241275
KCNA3 affects INS
| 1
KCNA3 activates INS. 1 / 1
| 1
reach
"Furthermore, down-regulation of potassium voltage gated channel shaker related subfamily 3 (KCNA3) significantly increased insulin stimulated glucose uptake through the GLUT4 glucose transporter, as reported by XREF_BIBR."
22272335
KCNA3 affects IL16
1 |
IL16 binds KCNA3. 1 / 1
1 |
hprd
No evidence text available
10479680
KCNA3 affects I
| 1
KCNA3 ubiquitinates I. 1 / 1
| 1
sparser
"Another group, studying a MIR1 homologue called MK3 in a murine herpesvirus, has independently determined that MK3 causes the ubiquitination and degradation of mouse MHC-I (Boname, J.M., et al. 2001."
| PMC
KCNA3 affects Hsp27
| 1
KCNA3 phosphorylates Hsp27. 1 / 1
| 1
sparser
"MK2, MK3, and MK5 can phosphorylate the common substrate small heat shock protein 27 (HSP27), a modification that regulates the role of HSP27 in actin polymerization."
21575178
KCNA3 affects HSPB1
| 1
KCNA3 phosphorylates HSPB1 on serine. 1 / 1
| 1
sparser
"MK2, MK3, and MK5 phosphorylate HSP27 in vitro at serine residues 15, 78 and 82 but with different stoichiometry."
21575178
KCNA3 affects EIF2S1
| 1
KCNA3 phosphorylates EIF2S1. 1 / 1
| 1
sparser
"A plausible explanation for this is that MK3 promotes phosphorylation of eIF2α (without eIF2α being a direct substrate of MK3), whereas MK2 inhibits this function of MK3, similar to that reported for the regulation of IRF3, IFNβ, IL10, IκBβ, and IκBα in macrophages where MK2 also prevented MK3 from exerting negative regulatory effects xref (cf. xref )."
23372691
KCNA3 affects EGFR
| 1
EGFR binds KCNA3. 1 / 1
| 1
sparser
"Moreover, these experiments strongly reinforce that EGFR does not physically interact with Kv1.3."
26542799
KCNA3 affects CTX
| 1
KCNA3 binds CTX. 1 / 1
| 1
sparser
"Analyzing the interaction of KTX and CTX with Kv1.3 will be helpful in understanding the recognition of MTX with Kv1 channels."
12414674
KCNA3 affects CTTN
1 |
CTTN binds KCNA3. 1 / 1
1 |
biogrid
No evidence text available
25739456
KCNA3 affects CD8
| 1
CD8 binds KCNA3. 1 / 1
| 1
sparser
"Overall these data indicate that the Kv1.3 expression in CD8 + cells is associated with a more active state, but unfortunately, these more active CD8 + cells preferentially localize in the stroma."
27815390
KCNA3 affects CD4
| 1
KCNA3 inhibits CD4. 1 / 1
| 1
reach
"Complete loss of Kcna3 can cause CD4 + T cells to take on properties of regulatory cells and reduce production of IFNgamma and IL17 cytokines."
28576921
KCNA3 affects CD3D
1 |
CD3D binds KCNA3. 1 / 1
1 |
biogrid
No evidence text available
12604782
KCNA3 affects APP
| 1
APP binds KCNA3. 1 / 1
| 1
sparser
"This particular study also revealed a “plaque-like” pattern of Kv1.3, suggesting that it may be possible for Aβ to interact with Kv1.3."
30323735
KCNA3 affects AIP
| 1
AIP binds KCNA3. 1 / 1
| 1
sparser
"Our findings provide the first evidence that KCNA3 is associated with AIP and suggest that KCNA3 may influence the risk for AIP."
22045429
KCNA1 affects KCNA3, and kcsA
| 1
KCNA1 binds KCNA3 and kcsA. 1 / 1
| 1
sparser
"We demonstrate that fluorescently labeled agitoxin 2 binds specifically to high-affinity and lower-affinity sites of KcsA-Kv1.3 and KcsA-Kv1.1, respectively, at the membrane of spheroplasts."
18649142
KCNA1 affects KCNA3, and OSK1
| 1
KCNA1 binds KCNA3 and OSK1. 1 / 1
| 1
sparser
"The potentials of mean force of the wild-type and mutant OSK1 bound to Kv1.1-Kv1.3 channels are constructed using molecular dynamics, and the half-maximal inhibitory concentration (IC(50)) of each toxin-channel complex is computed."
22352687
KCNA1 affects KCNA2, KCNA3, and voltage-gated potassium channel
| 1
KCNA1 binds KCNA2, KCNA3, and voltage-gated potassium channel. 1 / 1
| 1
sparser
"Recognition of interactions of kappa-Hefutoxin1 with the voltage-gated potassium channels, Kv1.1, Kv1.2, and Kv1.3, was studied by 3D-Dock software package."
18076029
KCNA1 affects KCNA2, KCNA3, and MTX1
| 1
KCNA1 binds KCNA2, KCNA3, and MTX1. 1 / 1
| 1
sparser
"In this study, by means of the Brownian dynamics (BD) method ( Ermak and McCammon, 1978 ), the association of MTX (all of the 35 available structures in the Protein Data Bank; 1TXM) with Kv1.1, Kv1.2, and Kv1.3 was simulated."
12414674
KCN affects KCNA3, and kcsA
| 1
KCN binds KCNA3 and kcsA. 1 / 1
| 1
sparser
"Our study provides a structural model for the chemical shift changes observed upon high-affinity binding of KTX to the chimeric potassium channel KcsA-Kv1.3."
18462679
JAK2 affects KCNA3
| 1 1
JAK2 activates KCNA3. 1 / 1
| 1 1
reach
"As a result, KCNA3 channel activity and protein abundance were up-regulated by coexpression of JAK2 or (V617F) JAK2 but not (K882E) JAK2."
25644777
Integrins affects KCNA3, and PLAU
| 1
Integrins binds KCNA3 and PLAU. 1 / 1
| 1
sparser
"Although it has been demonstrated that integrins interact with both urokinase-type plasminogen activator receptors and Kv1.3, whether or not all three molecules are simultaneously present in the same assembly is not known."
12084773
IL4 affects KCNA3
| 1
IL4 inhibits KCNA3. 1 / 1
| 1
reach
"IL-4 also decreased Kcna3, Kcna5, Kcnn4, and Trpm4 (after I+T)."
30087595
IL16 affects KCNA3
1 |
IL16 binds KCNA3. 1 / 1
1 |
hprd
No evidence text available
10479680
HOG1 affects KCNA3
| 1
HOG1 phosphorylates KCNA3. 1 / 1
| 1
sparser
"Osmotic stress activates Hog1, which phosphorylates the Nha1 Na/H antiporter and the Tok1 potassium channel ()."
24797924
GNPTAB affects KCNA1, KCNA3, and KCNE4
| 1
GNPTAB binds KCNA1, KCNA3, and KCNE4. 1 / 1
| 1
sparser
"These results indicate that KCNE4 proteins somehow interact with Kv1.1- and Kv1.3-subunits present in the heteromeric complexes and thereby modulate the entire Kv1 channel complex."
12944270
GNPTAB affects KCNA1, and KCNA3
| 1
GNPTAB binds KCNA1 and KCNA3. 1 / 1
| 1
sparser
"Potential interactions between other KCNE-subunits and Kv1.1 or Kv1.3 were also investigated in the oocyte expression system."
12944270
GCG affects KCNA3
| 1
GCG phosphorylates KCNA3. 1 / 1
| 1
sparser
"Insulin and the incretin hormone, GLP-1, can phosphorylate Kv1.3 at the plasma membrane, decrease Kv1.3 current and upregulate GLUT4 translocation to the membrane to facilitate glucose metabolism."
27242550
FGFR1 affects KCNA3
| 1
FGFR1 phosphorylates KCNA3. 1 / 1
| 1
sparser
"Biochemical analysis showed that OGD increased the tyrosine phosphorylation of native Kv1.3 protein, which was alleviated by PTK inhibitors or reactive oxygen species (ROS) scavengers."
10886336
FCGR2B affects KCNA3
| 1
FCGR2B inhibits KCNA3. 1 / 1
| 1
sparser
"Rituximab reduces the membrane potential of Daudi B cells via FcγRIIB receptor inhibition of Kv1.3 channels."
22192444
DLG4 affects INSR, and KCNA3
| 1
DLG4 binds INSR and KCNA3. 1 / 1
| 1
sparser
"Thus, insulin IND-treatment evokes activation of IR in situ and enhances the scaffolding association of Kv1.3, IR, and PSD-95 protein complexes."
19458242
DLG1 affects DLG4, and KCNA3
| 1
DLG1 binds DLG4 and KCNA3. 1 / 1
| 1
sparser
"Disruption of the interaction between PSD-95 or SAP97 and Kv1.3 in Jurkat was realized by the expression of a C-terminal truncated Kv1.3, which lacks the binding domain for these proteins, or by the knockdown of the expression of PSD-95 or SAP97 using specific shRNA."
23553419
ChTx affects KCNA3
| 1
ChTx inhibits KCNA3. 1 / 1
| 1
sparser
"In contrast, ChTx inhibits Kv1.3 ( K d  = 3 nM) and K Ca 3.1 ( K d  = 5 nM) with equal affinities ( 8,12 )."
24138859
CTX affects KCNA3
| 1
KCNA3 binds CTX. 1 / 1
| 1
sparser
"Analyzing the interaction of KTX and CTX with Kv1.3 will be helpful in understanding the recognition of MTX with Kv1 channels."
12414674
CTTN affects KCNA3
1 |
CTTN binds KCNA3. 1 / 1
1 |
biogrid
No evidence text available
25739456
CD8 affects KCNA3
| 1
CD8 binds KCNA3. 1 / 1
| 1
sparser
"Overall these data indicate that the Kv1.3 expression in CD8 + cells is associated with a more active state, but unfortunately, these more active CD8 + cells preferentially localize in the stroma."
27815390
CD3D affects KCNA3
1 |
CD3D binds KCNA3. 1 / 1
1 |
biogrid
No evidence text available
12604782
BAX affects KCNA1, KCNA3, and KCNA5
| 1
KCNA1 binds KCNA3, KCNA5, and BAX. 1 / 1
| 1
sparser
"Here we report that, like Kv1.3, Kv1.1 and Kv1.5 also interact with Bax."
22856664
APP affects KCNA3
| 1
APP binds KCNA3. 1 / 1
| 1
sparser
"This particular study also revealed a “plaque-like” pattern of Kv1.3, suggesting that it may be possible for Aβ to interact with Kv1.3."
30323735
AIP affects KCNA3
| 1
AIP binds KCNA3. 1 / 1
| 1
sparser
"Our findings provide the first evidence that KCNA3 is associated with AIP and suggest that KCNA3 may influence the risk for AIP."
22045429
5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate affects KCNA3
| 1
5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate inhibits KCNA3. 1 / 1
| 1
sparser
"The estimated value of the half-blocking concentration (EC 50 ) was about 5.76 µM. Among non-prenylated flavonoids, acacetin and chrysin inhibited Kv1.3 channels in Jurkat T cells when applied at the concentration of 30 µM, whereas baicalein, wogonin, and luteolin were ineffective at this concentration."
30187077
3A affects KCNA3
| 1
3A inhibits KCNA3. 1 / 1
| 1
sparser
"Expression of inactive MK2 KR or MK3 3A inhibited cytokine-stimulated IL-6 secretion to levels below that seen in Ad GFP cultures."
30205157