INDRA statements for KCNA2

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Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
RHOA affects KCNA2
3 1 | 1 18
KCNA2 binds RHOA. 22 / 22
3 1 | 1 18
sparser
"Coimmunoprecipitation experiments confirmed that RhoA associates with Kv1.2."
9635436
biogrid
No evidence text available
9635436
sparser
"To further define the interaction domain for RhoA binding to Kv1.2, we constructed a deletion mutant of Kv1.2 (Kv1.2-ΔN125) in which the distal 125 amino acids of the amino terminus were removed."
9635436
biogrid
No evidence text available
9635436
sparser
"To test whether the physical association of RhoA with Kv1.2 is required for the RhoA-induced effect on Kv1.2 ionic current, we used a mutant channel deficient in RhoA binding."
9635436
sparser
"Our finding that amino-terminal truncated Kv1.2 channels fail to become significantly suppressed by overexpression of RhoA indicates that the physical association of RhoA with Kv1.2 is necessary for its effect on Kv1.2 physiology."
9635436
sparser
"In human embryonic kidney 293 cells overexpressing Kv1.2, immunoprecipitation using an anti-RhoA antibody revealed an association of RhoA with Kv1.2."
9635436
sparser
"Does the association of RhoA with Kv1.2 have any physiological effect on ionic current generated by Kv1.2 channels?"
9635436
sparser
"To confirm this finding, we performed in vitro binding experiments, which demonstrated that the GTP-bound form of RhoA associates with the amino terminus of Kv1.2 preferentially over the GDP-bound form ( Figure 1 C)."
9635436
hprd
No evidence text available
9635436
biogrid
No evidence text available
9635436
sparser
"Here, we report the interaction between RhoA and the delayed rectifier potassium channel Kv1.2."
9635436
sparser
"Since Kv1.2 is endogenously expressed in NG108-15 neuroblastoma cells ( Yokoyama et al. 1989 ), we asked whether we could detect interactions between RhoA and Kv1.2 in this native system."
9635436
sparser
"After verifying that RhoA interacts with Kv1.2, we next asked whether this interaction affects Kv1.2 physiology."
9635436
sparser
"Physical interaction between RhoA and Kv1.2 channel indicates involvement of Kv1.2 channel in cell motility (Cachero et al., xref )."
26580832
sparser
"Therefore, the interaction between RhoA and Kv1.2 occurs in a native mammalian system."
9635436
sparser
"Using whole-cell lysates from NG108-15 cells, immunoprecipitation with anti-RhoA monoclonal antibody revealed that endogenous RhoA associates with the endogenous Kv1.2 protein ( Figure 1 A, bottom panel)."
9635436
sparser
"To determine whether the interaction between Kv1.2 and RhoA is cytoplasmic or takes place at the membrane level, we performed coimmunoprecipitation experiments in a crude membrane preparation using 293 cells stably expressing Kv1.2."
9635436
sparser
"RhoA coimmunoprecipitates Kv1.2 in the membrane ( Figure 1 B), suggesting that RhoA associates with Kv1.2 in its membrane-associated, GTP-bound state."
9635436
sparser
"We show that RhoA physically associates with the amino terminus of Kv1.2, and electrophysiological analyses reveal that, in Xenopus laevis oocytes, overexpression of RhoA markedly reduces the ionic current generated by coexpressed Kv1.2 channels."
9635436
sparser
"Therefore, RhoA binds to Kv1.2 preferentially in its activated, GTP-bound form."
9635436
sparser
"Our finding that RhoA associates with the amino terminus of Kv1.2 in a two hybrid assay was confirmed in a series of immunoprecipitation experiments."
9635436
DNMT3A affects KCNA2
| 2 18
DNMT3A activates KCNA2.
| 8
DNMT3A activates KCNA2. 8 / 8
| 8
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"In summary, our study reveals a DNMT3a triggered epigenetic mechanism of Kcna2 downregulation in the injured DRG after peripheral nerve injury."
28270689
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"The increased DNMT3a may participate in nerve injury induced Kcna2 downregulation in the injured DRG."
28270689
reach
"The increased DNMT3a may participate in PCC induced downregulation of the Kcna2 gene in ipsilateral dorsal horn."
29056068
reach
"The evidence described above strongly suggests the participation of DNMT3a in nerve injury induced Kcna2 downregulation in the injured DRG."
28270689
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR it is likely that an elevation of DNA methylation within the Kcna2 gene promotor caused by the increased DNMT3a interferes with the binding of transcription factors and/or serves as docking sites for methyl-CpG-binding domain proteins, resulting in Kcna2 gene silencing in the dorsal horn neurons under CPP induced bone cancer pain conditions, although the detailed mechanisms remain to be confirmed."
29056068
reach
"In conclusion, the current study demonstrates a DNMT3a triggered epigenetic mechanism of Kcna2 downregulation in the dorsal horn under bone cancer pain conditions."
29056068
reach
"However, it is worth noting that DNMT3a is expressed in other tissues and may target other genes in addition to Kcna2."
28270689
reach
"How DNMT3a specifically targets Kcna2 is unknown, but DNMT3a participation in nerve injury induced DRG Kcna2 silencing may be related to the increased binding of DNMT3a to the Kcna2 gene promoter region (-663/-199) and associated with an elevation in DNA methylation levels within this region after SNL."
28270689
DNMT3A inhibits KCNA2.
| 5
DNMT3A inhibits KCNA2. 5 / 5
| 5
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"DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons."
28270689
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"DNMT3a represses Kcna2 in DRG neurons."
28270689
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"DNMT3a overexpression markedly reduced Kcna2 promoter activity, which could be blocked when both -457 and -444 CpG sites were deleted (XREF_SUPPLEMENTARY)."
28270689
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"Whether the SNL induced increase in DNMT3a triggered DNA methylation occurs at other CpG sites within the Kcna2 gene regions that were not studied is unknown, but DNMT3a overexpression significantly reduced Kcna2 promoter activity, which could be rescued when both -457 and -444 CpG sites were deleted."
28270689
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"Indeed, overexpression of DNMT3a through transduction of HSV-Dnmt3a in cultured DRG neurons of Dnmt3a fl/fl mice reduced the level of Kcna2 mRNA, whereas knockdown of DNMT3a through transduction of AAV5-Cre in in vitro cultured DRG neurons of Dnmt3a fl/fl mice substantially increased Kcna2 mRNA expression (XREF_FIG)."
28270689
DNMT3A decreases the amount of KCNA2.
| 3
DNMT3A decreases the amount of KCNA2. 3 / 3
| 3
reach
"These findings suggest that DNMT3a may contribute to neuropathic pain by repressing MOR, KOR and Kcna2 expression in the DRG."
29930500
reach
"Indeed, overexpression of DNMT3a through transduction of HSV-Dnmt3a in cultured DRG neurons of Dnmt3a fl/fl mice reduced the level of Kcna2 mRNA, whereas knockdown of DNMT3a through transduction of AAV5-Cre in in vitro cultured DRG neurons of Dnmt3a fl/fl mice substantially increased Kcna2 mRNA expression (XREF_FIG)."
28270689
reach
"These findings suggest that DNMT3a may contribute to neuropathic pain by repressing Kcna2 expression in the DRG."
28270689
DNMT3A increases the amount of KCNA2.
| 2
DNMT3A increases the amount of KCNA2. 2 / 2
| 2
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"Finally, we observed whether these effects were mediated through OCT1 regulation of DNMT3a triggered Oprm1 and Kcna2 gene expression in the DRG."
30247265
reach
"Our in vitro DRG neuronal culture studies further demonstrated that DNMT3a directly regulated the expression of Kcna2, but not Kcna1 and Kcna4."
28270689
DNMT3A binds KCNA2.
| 2
DNMT3A binds KCNA2. 2 / 2
| 2
sparser
"We further used ChIP assays and found that DNMT3a binds to two regions (−663/−389 bp and −491/−199 bp) of the Kcna2 gene promoter, as demonstrated by the amplification of only these two regions (out of 7 regions from –663 to +928 bp) from the complexes immunoprecipitated with DNMT3a antibody in nuclear fractions from sham DRG ( xref )."
28270689
sparser
"How DNMT3a specifically targets Kcna2 is unknown, but DNMT3a participation in nerve injury-induced DRG Kcna2 silencing may be related to the increased binding of DNMT3a to the Kcna2 gene promoter region (−663/−199) and associated with an elevation in DNA methylation levels within this region after SNL."
28270689
MZF1 affects KCNA2
| 5 10
MZF1 binds KCNA2.
| 5 1
MZF1 binds KCNA2. 2 / 2
| 1 1
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"This amplification did not occur with normal serum (XREF_FIG) or after pre-absorption of MZF1 antibody (data not shown), indicating that the binding of MZF1 to Kcna2 antisense RNA promoter is specific and selective."
23792947
sparser
"MZF1-triggered downregulation of Kcna2 does not occur likely by direct binding of MZF1 to the Kcna2 gene promoter."
23792947
SLC22A18AS binds MZF1 and KCNA2. 2 / 2
| 2
sparser
"SNL increased the binding of MZF1 to the Kcna2 antisense gene promoter, as demonstrated by a 4.12-fold increase in band density in the ipsilateral L 5 DRG from SNL rats compared to that from sham rats on day 14 (n=6 rats/group, P <0.05)."
23792947
sparser
"This amplification did not occur with normal serum ( xref ) or after pre-absorption of MZF1 antibody (data not shown), indicating that the binding of MZF1 to Kcna2 antisense RNA promoter is specific and selective."
23792947
MZF1 binds KCNA2 and AS. 1 / 1
| 1
sparser
"Peripheral nerve injury up-regulates the expression of MZF1 in the DRG and increases the binding activity of MZF1 to the promoter region of the Kv1.2 AS RNA gene [ xref ]."
25630025
SLC22A18AS binds MZF1, KCNA2, and DRG. 1 / 1
| 1
sparser
"These in vivo findings suggest that peripheral nerve injury increases DRG MZF1 expression, allowing the binding of more MZF1 to the promoter region of Kcna2 antisense gene in the injured DRG neurons."
23792947
MZF1 activates KCNA2.
| 5
MZF1 activates KCNA2. 5 / 5
| 5
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"We found that Kcna2 SE RNA fragment blocked MZF1 induced increase in Kcna2 antisense RNA and reversed MZF1 induced reduction in Kcna2 mRNA in DRG neurons (XREF_FIG)."
23792947
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"MZF1 promotes Kcna2 antisense RNA gene activity after SNL."
23792947
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"Thus, MZF1 induced Kcna2 downregulation may be attributable to MZF1 triggered Kcna2 antisense gene expression."
23792947
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"MZF1 does not enhance the activity of Kcna2 gene promoter but dramatically activates the Kcna2 antisense gene promoter (n = 3 repeats and treatment, P < 0.01; XREF_FIG)."
23792947
reach
"MZF1 mediated increase of Kcna2 AS RNA after nerve injury."
24739997
MZF1 increases the amount of KCNA2.
| 2
MZF1 increases the amount of KCNA2. 2 / 2
| 2
reach
"To further examine whether MZF1 directly regulates Kcna2 antisense RNA expression, we overexpressed full-length MZF1 in cultured HEK-293T cells (XREF_SUPPLEMENTARY) that express endogenous Kcna2 antisense RNA, Kcna2, and other Kv channels."
23792947
reach
"Moreover, MZF1 directly promotes Kcna2 AS gene transcription and is co-expressed with Kcna2 AS RNA in DRG neurons 16."
24739997
MZF1 inhibits KCNA2.
| 1
MZF1 inhibits KCNA2. 1 / 1
| 1
reach
"MZF1 overexpression significantly increased Kcna2 antisense RNA and correspondingly decreased Kcna2 mRNA and protein (n = 5 repeats and treatment, P < 0.05 or 0.01; XREF_FIG)."
23792947
MZF1 decreases the amount of KCNA2.
| 1
MZF1 decreases the amount of KCNA2. 1 / 1
| 1
reach
"MZF1 siRNA transfection alone also reduced basal Kcna2 antisense RNA expression and increased basal expression of Kcna2 mRNA and protein (XREF_FIG)."
23792947
KCNA2 affects CTTN
4 1 | 3 8
CTTN binds KCNA2. 12 / 12
4 1 | 3 7
sparser
"These data also suggest that the Kv1.2 ‐cortactin interaction is greater in Kv1.2‐C COS‐7 cells than in WT COS‐7 cells, possibly due to the fact that Kv1.2‐C COS‐7 cells essentially expressed more Kv1.2 channel proteins which subsequently bound higher quantity of cortactin."
26580832
sparser
"Mutagenesis studies revealed that phosphorylation of Kv1.2 Y415 and Y417 causes disruption of Kv1.2 interaction with the cytoskeletal protein cortactin, and loss of interaction with cortactin diminishes the total Kv1.2 current in heterologous expression systems [ xref ]."
20600597
sparser
"We show that M1 receptor activation also reduces the interaction of cortactin with Kv1.2 and that mutant Kv1.2 channels deficient for cortactin binding exhibit strongly attenuated ionic current."
12151401
biogrid
No evidence text available
12151401
sparser
"We report that the potassium channel Kv1.2 associates with the actin-binding protein cortactin and that the binding is modulated by tyrosine phosphorylation."
12151401
biogrid
No evidence text available
17959782
hprd
No evidence text available
12151401
sparser
"It was well established that cortactin played a critical role in cell migration through its interaction with small GTPases and F‐actin (Kowalski et al., xref ; Van Rossum et al., xref ; MacGrath and Koleske, xref ), and that cortactin directly binds to Kv1.2 and modulates channel functions (Williams et al., xref )."
26580832
sparser
"We use FRET to demonstrate that Kv1.2 and cortactin interact in vivo."
17959782
biogrid
No evidence text available
12151401
biogrid
No evidence text available
17959782
sparser
"These results demonstrate a dynamic, phosphorylation-dependent interaction between Kv1.2 and the actin cytoskeleton-binding protein cortactin and suggest a role for that interaction in the regulation of Kv1.2 ionic current."
12151401
CTTN binds KCNA2 and cya. 1 / 1
| 1
sparser
"The result showed that EF triggered Kv1.2 channel binding to scaffolding protein cortactin (Fig. xref )."
26580832
SIGMAR1 affects KCNA2
| 7
KCNA2 binds SIGMAR1. 7 / 7
| 7
sparser
"More importantly, Sig-1R interacts with Kv1.2 in baseline conditions to influence bimodal activation gating."
31222975
sparser
"x channel family; however, the biophysical nature of the interaction between Sig-1R and Kv1.2 has not been elucidated."
31222975
sparser
"The activation of Sigma-1 receptor enhances the trafficking of Kv1.2 channels to the PM in both the nucleus accumbens (NAc) and the prefrontal cortex (PFC), which is proposed to be mediated by Sigma-1 receptor-Kv1.2 interaction."
31178723
sparser
"In this report, cocaine exposure induces Sig-1R translocation to the plasma membrane and shapes intrinsic plasticity via the persistent association of Sig-1R and Kv1.2 in the nucleus accumbens shell medium spiny neuron [ xref ]."
26869505
sparser
"These data suggest that Kvβ2 occludes the interaction of Sig-1R with Kv1.2, and that E102 may be a residue critical for Sig-1R modulation of Kv1.2."
31222975
sparser
"Cocaine increases the interaction between Sig-1R and Kv1.2 likely in the plasma membrane due to an increased Kv1.2 in the plasma membrane as a consequence of the activation and translocation of Sig-1R from the ER to the plasma membrane."
27088037
sparser
"The Sig-1R-Kv1.2 interaction has been shown to shape neuronal and behavioral responses to cocaine [ xref ]."
26869505
SLC22A18AS affects KCNA2
| 6
SLC22A18AS binds KCNA2. 3 / 3
| 3
sparser
"Peripheral nerve injury increases Kcna2 antisense RNA expression in injured DRG through activation of myeloid zinc finger protein 1, a transcription factor that binds to Kcna2 antisense RNA gene promoter."
23792947
sparser
"Moreover, Kcna2 antisense RNA, a conserved long noncoding RNA (lncRNA) responsible for a voltage-dependent potassium channel Kv1.2, largely located in first-order sensory neurons of the DRG is markedly increased in injured DRG through activation of myeloid zinc finger protein 1, a transcription factor that binds to the Kcna2 antisense RNA gene promoter, contributing to the development and maintenance of neuropathic pain [ xref ]."
25027291
sparser
"Peripheral nerve injury increased Kcna2 antisense RNA expression in injured DRG through activation of myeloid zinc finger protein 1, a transcription factor that binds to the Kcna2 antisense RNA gene promoter."
23792947
SLC22A18AS binds MZF1 and KCNA2. 2 / 2
| 2
sparser
"SNL increased the binding of MZF1 to the Kcna2 antisense gene promoter, as demonstrated by a 4.12-fold increase in band density in the ipsilateral L 5 DRG from SNL rats compared to that from sham rats on day 14 (n=6 rats/group, P <0.05)."
23792947
sparser
"This amplification did not occur with normal serum ( xref ) or after pre-absorption of MZF1 antibody (data not shown), indicating that the binding of MZF1 to Kcna2 antisense RNA promoter is specific and selective."
23792947
SLC22A18AS binds MZF1, KCNA2, and DRG. 1 / 1
| 1
sparser
"These in vivo findings suggest that peripheral nerve injury increases DRG MZF1 expression, allowing the binding of more MZF1 to the promoter region of Kcna2 antisense gene in the injured DRG neurons."
23792947
KCNA2 affects MZF1
| 5 1
MZF1 binds KCNA2. 2 / 2
| 1 1
reach
"This amplification did not occur with normal serum (XREF_FIG) or after pre-absorption of MZF1 antibody (data not shown), indicating that the binding of MZF1 to Kcna2 antisense RNA promoter is specific and selective."
23792947
sparser
"MZF1-triggered downregulation of Kcna2 does not occur likely by direct binding of MZF1 to the Kcna2 gene promoter."
23792947
SLC22A18AS binds MZF1 and KCNA2. 2 / 2
| 2
sparser
"SNL increased the binding of MZF1 to the Kcna2 antisense gene promoter, as demonstrated by a 4.12-fold increase in band density in the ipsilateral L 5 DRG from SNL rats compared to that from sham rats on day 14 (n=6 rats/group, P <0.05)."
23792947
sparser
"This amplification did not occur with normal serum ( xref ) or after pre-absorption of MZF1 antibody (data not shown), indicating that the binding of MZF1 to Kcna2 antisense RNA promoter is specific and selective."
23792947
MZF1 binds KCNA2 and AS. 1 / 1
| 1
sparser
"Peripheral nerve injury up-regulates the expression of MZF1 in the DRG and increases the binding activity of MZF1 to the promoter region of the Kv1.2 AS RNA gene [ xref ]."
25630025
SLC22A18AS binds MZF1, KCNA2, and DRG. 1 / 1
| 1
sparser
"These in vivo findings suggest that peripheral nerve injury increases DRG MZF1 expression, allowing the binding of more MZF1 to the promoter region of Kcna2 antisense gene in the injured DRG neurons."
23792947
PTK2B affects KCNA2
1 1 | 1 3
PTK2B phosphorylates KCNA2.
| 1 3
PTK2B phosphorylates KCNA2. 3 / 3
| 1 3
sparser
"For example, Felsch et al. [ xref ] reported that Pyk2 phosphorylates the potassium channel Kv1.2 in response to the activation of m1 muscarinic acetylcholine receptor."
20180987
sparser
"Delayed rectifier K(+) channels may mediate the PYK2 activity because Kv1.2 channel protein co-immunoprecipitated with PYK2 and tyrosine phosphorylation of Kv1.2 was stimulated by AVP and inhibited by Ro-31-8220, PP2, and salicylate but not tyrphostin A47."
11739373
sparser
"However, phosphorylation of Kv1.2 by Pyk2 may well have other, more long-term regulatory effects on the channel and its associated proteins."
11781137
PTK2B binds KCNA2.
1 1 |
KCNA2 binds PTK2B. 2 / 2
1 1 |
hprd
No evidence text available
11739373
biogrid
No evidence text available
11739373
MTX1 affects KCNA2
| 5
KCNA2 binds MTX1. 4 / 4
| 4
sparser
"In all, the pairs of interacting residues on MTX and the IK(Ca) channel of the bound complex indicated that electrostatic and Van der Waal interactions contributed equally to the formation of a stable MTX-IK(Ca) complex, in contrast to the MTX-Kv1.2 binding that is dominantly mediated by electrostatic forces."
21262000
sparser
"The principal MTX-Kv1.2 channel interactions derived from the refined structure were analyzed and displayed using the LIGPLOT program ( McDonald and Thornton, 1994; Wallace et al., 1995 ), shown in Fig. 9 ."
12414674
sparser
"Our triplet analyses of the BD simulations show that Lys27 in MTX interacts with Asp378 in Kv1.2 ( Table 2 )."
12414674
sparser
"Despite the unusual disulfide bridge motif, the binding of MTX to Kv1.2 belongs to the first situation, i.e., mainly via its two antiparallel β -sheets, whereas its α -helix is far away from the interaction surface of the Kv1 channel."
12414674
KCNA1 binds KCNA2, KCNA3, and MTX1. 1 / 1
| 1
sparser
"In this study, by means of the Brownian dynamics (BD) method ( Ermak and McCammon, 1978 ), the association of MTX (all of the 35 available structures in the Protein Data Bank; 1TXM) with Kv1.1, Kv1.2, and Kv1.3 was simulated."
12414674
KCNA2 affects DLG4
2 3 |
DLG4 binds KCNA2. 5 / 5
2 3 |
biogrid
No evidence text available
12435606
hprd
No evidence text available
12435606
hprd
No evidence text available
7477295
biogrid
No evidence text available
12435606
hprd
No evidence text available
8938729
PTPRA affects KCNA2
2 2 |
KCNA2 binds PTPRA. 4 / 4
2 2 |
biogrid
No evidence text available
9878055
biogrid
No evidence text available
9878055
hprd
No evidence text available
9878055
hprd
No evidence text available
15588985
KCNA2 affects Lys-Val
| 4
KCNA2 inhibits Lys-Val.
| 2
KCNA2 inhibits Lys-Val. 2 / 2
| 2
reach
"These data indicate that Kcna2 antisense RNA reduces total Kv current densities in large and medium DRG neurons and decreases Kcna2 related current in all neurons."
23792947
reach
"However, the fact that Kcna2 downregulation markedly reduced total Kv current density in large and medium DRG neurons indicates that Kcna2 is a key subunit in determining Kv channel function in these neurons."
23792947
KCNA2 activates Lys-Val.
| 2
KCNA2 activates Lys-Val. 2 / 2
| 2
reach
"We found that selective reduction of Kcna2 expression in DRG by Kcna2 AS RNA decreased total Kv current, depolarized the resting membrane potential, decreased current threshold for activation of action potentials, increased the number of action potentials in large and medium DRG neurons, and produced neuropathic pain symptoms 16."
24739997
reach
"We found that selective reduction of Kcna2 expression in DRG by Kcna2 antisense RNA decreased total Kv current, depolarized the resting membrane potential, decreased current threshold for activation of action potentials, and increased the number of action potentials in large and medium DRG neurons."
23792947
KCNA2 affects ETV1
4 |
ETV1 binds KCNA2. 4 / 4
4 |
hprd
No evidence text available
11551945
hprd
No evidence text available
12569367
hprd
No evidence text available
12213813
hprd
No evidence text available
12917345
CEBPB affects KCNA2
| 4
CEBPB inhibits KCNA2. 4 / 4
| 4
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"In the ipsilateral DRG, C/EBPbeta promoted a decrease in the abundance of the voltage gated potassium channel subunit Kv1.2 and mu opioid receptor (MOR) at the mRNA and protein levels, which would be predicted to increase excitability in the ipsilateral DRG neurons and reduce the efficacy of morphine analgesia."
28698219
reach
"Other C/EBPbeta independent mechanisms are involved in the nerve injury induced suppression of Kcna2 and Oprm1 in the ipsilateral DRG, such as transcriptional activation of Kcna2 antisense RNA by myeloid zinc finger protein 1."
28698219
reach
"In the ipsilateral DRG, C/EBPbeta promoted a decrease in the abundance of the voltage gated potassium channel subunit Kv1.2 and micro opioid receptor (MOR) at the mRNA and protein levels, which would be predicted to increase excitability in the ipsilateral DRG neurons and reduce the efficacy of morphine analgesia."
28698219
reach
"C/EBPbeta promoted the G9a mediated epigenetic silencing of Kcna2 and Oprm1 in the ipsilateral DRG."
28698219
VEGF affects KCNA2
| 2 1
VEGF phosphorylates KCNA2. 2 / 2
| 1 1
rlimsp
"Finally, the enhancement of the tyrosine phosphorylation of the channel by VEGF in neuronal cells was significantly attenuated in the presence of wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3-K), or genestin, an inhibitor of tyrosine kinase, thus suggesting that the phosphorylation of Kv 1.2 induced by VEGF is mechanistically linked to the PI3-K pathway."
14713306
sparser
"In contrast, in SH-SY5Y subjected to hypoxia and glucose deprivation, attenuation of cell death was achieved by tyrosine phosphorylation of Kv1.2 by VEGF [ xref ]."
19305791
VEGF phosphorylates KCNA2 on tyrosine. 1 / 1
| 1
rlimsp
"In substantiation of this result, we used anti-sense methodology to suppress the expression of endogenous VEGF, which significantly inhibited the tyrosine phosphorylation of Kv 1.2 and increased cell death elicited by ischemic/hypoxic injury."
14713306
KCNA2 affects MCF2L2
| 3
KCNA2 activates MCF2L2.
| 2
KCNA2 activates MCF2L2. 2 / 2
| 2
reach
"We found that MZF1 binds to this motif on the Kcna2 AS gene promoter in the DRG 16, and SNL time-dependently increases MZF1 expression and its binding activity in the injured DRG 16."
24739997
reach
"To assess whether Kcna2 antisense RNA modulates DRG neuronal excitability, we carried out whole-cell current-clamp recording 8-12 weeks post-injection."
23792947
KCNA2 inhibits MCF2L2.
| 1
KCNA2 inhibits MCF2L2. 1 / 1
| 1
reach
"Our findings indicate that Kcna2 knockdown or current inhibition increases DRG neuronal excitability."
23792947
FSCN1 affects KCNA2
| 3
FSCN1 activates KCNA2.
| 2
FSCN1 activates KCNA2. 2 / 2
| 2
reach
"To examine the role of Kcna2 antisense RNA in neuropathic pain induction, we subjected rats to SNL 4 weeks after DRG viral injection, as our pilot work showed that the level of Kcna2 SE RNA fragment was too low to block SNL induced Kcna2 antisense RNA expression before that time."
23792947
reach
"Intrathecal administration of BIX01294 also blocked the SNL induced increase in the level of H3K9me2, a marker of G9a activity, and reversed SNL induced downregulation of Oprm1 mRNA, Oprk1 mRNA, Oprd1 mRNA, Kcna2 mRNA, and Kcna4 mRNA, the downstream targets of G9a, in the ipsilateral L5 DRG."
31497620
FSCN1 increases the amount of KCNA2.
| 1
FSCN1 increases the amount of KCNA2. 1 / 1
| 1
reach
"These increases are DNMT3a dependent as blocking the SNL induced upregulation in DRG DNMT3a abolished the SNL induced elevation in Kcna2 DNA methylation level at these two CpG sites."
28270689
DRG DNMT3a affects KCNA2
| 3
DRG DNMT3a decreases the amount of KCNA2.
| 2
DRG DNMT3a decreases the amount of KCNA2. 2 / 2
| 2
reach
"These increases are DNMT3a dependent as blocking the SNL induced upregulation in DRG DNMT3a abolished the SNL induced elevation in Kcna2 DNA methylation level at these two CpG sites."
28270689
reach
"Blocking the SNL induced increase in DRG DNMT3a via its genetic knockout or knockdown restored the expression of Kcna2, but not Kcna1 and Kcna4, in the injured DRG, whereas mimicking the SNL induced increase in DRG DNMT3a via its genetic overexpression decreased the expression of Kcna2, but not Kcna4, in the DRG of naive rat."
28270689
DRG DNMT3a increases the amount of KCNA2.
| 1
DRG DNMT3a increases the amount of KCNA2. 1 / 1
| 1
reach
"Blocking the SNL induced increase in DRG DNMT3a via its genetic knockout or knockdown restored the expression of Kcna2, but not Kcna1 and Kcna4, in the injured DRG, whereas mimicking the SNL induced increase in DRG DNMT3a via its genetic overexpression decreased the expression of Kcna2, but not Kcna4, in the DRG of naive rat."
28270689
Pyraclofos affects KCNA2
| 2
Pyraclofos activates KCNA2. 2 / 2
| 2
sparser
"The corresponding simulation model is in some respect a simplified way of generating the trend in the Kv1.2 voltage-activated channel. xref , xref "
29156125
sparser
"Among neuronal Kv channels, the low voltage-activated Kv1.1 and Kv1.2 are expressed mainly in the cerebellum, hippocampus, and thalamus."
23675382
Potassium(1+) affects KCNA2
| 2
Potassium(1+) binds KCNA2. 1 / 1
| 1
sparser
"We hypothesize that the differential sorting of Kv1.2 could result from association of Kv1.2 with varying heterologous K+ channel subunits in different cell types, with the implication that Kv1.2 may participate in distinct heteromultimeric K+ channels in different subcellular domains."
8158277
Potassium(1+) binds KCNA2 and KCNA4. 1 / 1
| 1
sparser
"We present here biochemical evidence that Kv1.4 and Kv1.2, two K+ channel subunits of the Shaker subfamily, co-assemble in rat brain."
8361540
Phosphatidylinositol phosphate affects KCNA2
| 2
Phosphatidylinositol phosphate binds KCNA2. 2 / 2
| 2
sparser
"These interactions were different from the PIP 2 -Shaker and PIP 2 -Kv1.2 interactions [69] ."
32288960
sparser
"Interactions between the S4–S5 linker of Kv1.2 and PIP 2 inhibit voltage activation by restricting outward movement of the voltage sensor ( xref ), but sites involved in PIP 2 -dependent enhancement have not been identified."
26503718
Mdb1 affects KCNA2
| 2
Mdb1 decreases the amount of KCNA2. 2 / 2
| 2
reach
"We have also provided the evidence that MDB1 represses Oprm1 and Kcna2 gene expression by recruiting DNA methyltransferase DNMT3a into these two gene promoters in the DRG neurons."
30266739
reach
"Mechanistically, MDB1 represses Oprm1 and Kcna2 gene expression by recruiting DNA methyltransferase DNMT3a into these two gene promoters in the DRG neurons."
30266739
UBA2 affects KCNA2
| 2
KCNA2 binds UBA2. 1 / 1
| 1
sparser
"These interactions were different from the PIP2–Shaker and PIP2–Kv1.2 interactions [69]."
32288960
UBA2 binds KCNA2. 1 / 1
| 1
sparser
"These interactions are different from the PIP2-Shaker and PIP2-Kv1.2 interactions."
24277843
Notch affects KCNA2
| 2
Notch inhibits KCNA2. 2 / 2
| 2
reach
"Furthermore, activation of Notch attenuates whole-cell K + currents in KCNA5- and KCNA2 transfected cells."
32186932
reach
"Furthermore, activation of Notch attenuates whole-cell K + currents in KCNA5- and KCNA2 transfected cells."
32186932
NOG affects KCNA2
2 |
Transcriptionally active NOG increases the amount of KCNA2. 2 / 2
2 |
biopax:ctd
No evidence text available
27188386
biopax:ctd
No evidence text available
27188386
Kcna2 SE affects KCNA2
| 2
Kcna2 SE inhibits KCNA2.
| 1
Kcna2 SE inhibits KCNA2. 1 / 1
| 1
reach
"We found that Kcna2 SE RNA fragment blocked MZF1 induced increase in Kcna2 antisense RNA and reversed MZF1 induced reduction in Kcna2 mRNA in DRG neurons (XREF_FIG)."
23792947
Kcna2 SE activates KCNA2.
| 1
Kcna2 SE activates KCNA2. 1 / 1
| 1
reach
"We found that Kcna2 SE RNA fragment blocked MZF1 induced increase in Kcna2 antisense RNA and reversed MZF1 induced reduction in Kcna2 mRNA in DRG neurons (XREF_FIG)."
23792947
KCNA2 affects potassium(1+)
| 2
Potassium(1+) binds KCNA2. 1 / 1
| 1
sparser
"We hypothesize that the differential sorting of Kv1.2 could result from association of Kv1.2 with varying heterologous K+ channel subunits in different cell types, with the implication that Kv1.2 may participate in distinct heteromultimeric K+ channels in different subcellular domains."
8158277
Potassium(1+) binds KCNA2 and KCNA4. 1 / 1
| 1
sparser
"We present here biochemical evidence that Kv1.4 and Kv1.2, two K+ channel subunits of the Shaker subfamily, co-assemble in rat brain."
8361540
KCNA2 affects phosphatidylinositol phosphate
| 2
Phosphatidylinositol phosphate binds KCNA2. 2 / 2
| 2
sparser
"These interactions were different from the PIP 2 -Shaker and PIP 2 -Kv1.2 interactions [69] ."
32288960
sparser
"Interactions between the S4–S5 linker of Kv1.2 and PIP 2 inhibit voltage activation by restricting outward movement of the voltage sensor ( xref ), but sites involved in PIP 2 -dependent enhancement have not been identified."
26503718
KCNA2 affects UBA2
| 2
KCNA2 binds UBA2. 1 / 1
| 1
sparser
"These interactions were different from the PIP2–Shaker and PIP2–Kv1.2 interactions [69]."
32288960
UBA2 binds KCNA2. 1 / 1
| 1
sparser
"These interactions are different from the PIP2-Shaker and PIP2-Kv1.2 interactions."
24277843
KCNA2 affects SH2B2
| 2
KCNA2 inhibits SH2B2.
| 1
KCNA2 inhibits SH2B2. 1 / 1
| 1
reach
"Ventricular Kcna2 AS expression increases in rats with CHF and contributes to reduced I K s, prolonged APs, and the occurrence of ventricular arrhythmias by silencing Kcna2."
29263036
KCNA2 activates SH2B2.
| 1
KCNA2 activates SH2B2. 1 / 1
| 1
reach
"Kcna2 knockdown in the heart decreased the I Ks and prolonged APs in cardiomyocytes, consistent with the changes observed in heart failure."
29263036
KCNA2 affects PTK2B
1 1 |
KCNA2 binds PTK2B. 2 / 2
1 1 |
hprd
No evidence text available
11739373
biogrid
No evidence text available
11739373
KCNA2 affects MZF1, and SLC22A18AS
| 2
SLC22A18AS binds MZF1 and KCNA2. 2 / 2
| 2
sparser
"SNL increased the binding of MZF1 to the Kcna2 antisense gene promoter, as demonstrated by a 4.12-fold increase in band density in the ipsilateral L 5 DRG from SNL rats compared to that from sham rats on day 14 (n=6 rats/group, P <0.05)."
23792947
sparser
"This amplification did not occur with normal serum ( xref ) or after pre-absorption of MZF1 antibody (data not shown), indicating that the binding of MZF1 to Kcna2 antisense RNA promoter is specific and selective."
23792947
KCNA2 affects Lys-Ser
| 2
KCNA2 inhibits Lys-Ser.
| 1
KCNA2 inhibits Lys-Ser. 1 / 1
| 1
reach
"Conversely, Kcna2 overexpression in the heart significantly attenuated the CHF induced decreases in the I Ks, AP prolongation, and ventricular arrhythmias."
29263036
KCNA2 activates Lys-Ser.
| 1
KCNA2 activates Lys-Ser. 1 / 1
| 1
reach
"Kcna2 knockdown in the heart decreased the I Ks and prolonged APs in cardiomyocytes, consistent with the changes observed in heart failure."
29263036
KCNA2 affects DRG Kcna2
| 2
KCNA2 decreases the amount of DRG Kcna2.
| 1
Modified KCNA2 decreases the amount of DRG Kcna2. 1 / 1
| 1
reach
"Overexpression of Kcna2 antisense RNA decreased expression of DRG Kcna2 mRNA and protein and increased the excitability of large- and medium sized DRG neurons."
23980191
KCNA2 activates DRG Kcna2.
| 1
KCNA2 activates DRG Kcna2. 1 / 1
| 1
reach
"We previously reported that an endogenous Kcna2 antisense (AS) RNA, a long non coding RNA, is a trigger in nerve injury induced DRG Kcna2 downregulation under neuropathic pain conditions XREF_BIBR XREF_BIBR XREF_BIBR."
27874088
KCNA2 affects DNMT3A
| 2
DNMT3A binds KCNA2. 2 / 2
| 2
sparser
"We further used ChIP assays and found that DNMT3a binds to two regions (−663/−389 bp and −491/−199 bp) of the Kcna2 gene promoter, as demonstrated by the amplification of only these two regions (out of 7 regions from –663 to +928 bp) from the complexes immunoprecipitated with DNMT3a antibody in nuclear fractions from sham DRG ( xref )."
28270689
sparser
"How DNMT3a specifically targets Kcna2 is unknown, but DNMT3a participation in nerve injury-induced DRG Kcna2 silencing may be related to the increased binding of DNMT3a to the Kcna2 gene promoter region (−663/−199) and associated with an elevation in DNA methylation levels within this region after SNL."
28270689
KCNA2 affects CNTNAP2
2 | 3
CNTNAP2 binds KCNA2. 1 / 1
1 | 3
hprd
No evidence text available
10624965
CNTNAP2 binds KCNA1, KCNA2, and KCNAB2. 1 / 1
1 |
hprd
No evidence text available
10624965
AS affects KCNA2
| 2
AS inhibits KCNA2.
| 1
AS inhibits KCNA2. 1 / 1
| 1
sparser
"Kcna2 AS inhibition increased the CHF-induced downregulation of Kcna2."
29263036
AS binds KCNA2.
| 1
MZF1 binds KCNA2 and AS. 1 / 1
| 1
sparser
"Peripheral nerve injury up-regulates the expression of MZF1 in the DRG and increases the binding activity of MZF1 to the promoter region of the Kv1.2 AS RNA gene [ xref ]."
25630025
AAV5-GFP affects KCNA2
| 2
AAV5-GFP increases the amount of KCNA2. 2 / 2
| 2
reach
"Similarly, microinjection of AAV5-Cre, but not AAV5-GFP, into the ipsilateral L4 DRG of Dnmt3a fl/fl mice markedly restored the expression of Kcna2 mRNA and protein in the injured L4 DRG on day 7 post-SNL (XREF_FIG)."
28270689
reach
"Injection of AAV5-Cre, but not AAV5-GFP, rescued the expression of Kcna2 and Kcna4 mRNAs and proteins in the axotomized DRG on day 7 post-SNL (XREF_FIG)."
27874088
Zinc finger protein affects KCNA2
| 1
KCNA2 binds zinc finger protein. 1 / 1
| 1
reach
"Moreover, Kcna2 antisense RNA, a conserved long noncoding RNA (lncRNA) responsible for a voltage dependent potassium channel Kv1.2, largely located in first-order sensory neurons of the DRG is markedly increased in injured DRG through activation of myeloid zinc finger protein 1, a transcription factor that binds to the Kcna2 antisense RNA gene promoter, contributing to the development and maintenance of neuropathic pain [XREF_BIBR]."
25027291
Rheobase affects KCNA2
| 1
Rheobase inhibits KCNA2. 1 / 1
| 1
reach
"The higher expression of Kcna2 (Kv1.2), Kcnab1 (Kv.1.3), and Hcn1 detected in striatal Pvalb expressing cells compared to their cortical counterparts can explain their latency to first spike (delayed firing) (Kcna2), reduced AHP amplitude (Kcna2 and Kcnab1), increased rheobase (Kcnab1), and lower input resistance and membrane time constant (Hcn1)."
30134177
Mgt affects KCNA2
| 1
Mgt inhibits KCNA2. 1 / 1
| 1
sparser
"However, both Kv1.2 and Kv1.3 were inhibited by MgTx at this concentration ( xref , Mann-Whitney U, non-parametric paired t -test, p = 0.0013 for Kv1.2, n = 6-7; p = 0.0001 for Kv1.3, n = 16-18)."
27861889
Dihydroartemisinin affects KCNA2
| 1
Dihydroartemisinin inhibits KCNA2. 1 / 1
| 1
sparser
"Micromolar concentrations of extracellular Zn2+ non-competitively antagonized DHA inhibition of Kv1.2 channels, whereas there was little effect on DHA block of Kv3.1a channels."
8938727
ZFP1 affects KCNA2
| 1
ZFP1 activates KCNA2. 1 / 1
| 1
sparser
"Other C/EBPβ-independent mechanisms are involved in the nerve injury–induced suppression of Kcna2 and Oprm1 in the ipsilateral DRG, such as transcriptional activation of Kcna2 antisense RNA by myeloid zinc finger protein 1 ( xref , xref , xref )."
28698219
Voltage_gated_ion_channels affects KCNA2
| 1
Voltage_gated_ion_channels binds KCNA2. 1 / 1
| 1
sparser
"Then, by employing electrophysiological recordings as well as biochemical studies on ex vivo tissue and heterologous cells, they confirmed that the σ-1R's interaction with voltage-gated K + channel Kv1.2 contributes/participates in the behavioral response (locomotor sensitization) to cocaine."
23630466
TM affects KCNA2
| 1
KCNA2 binds TM. 1 / 1
| 1
sparser
"The TM assembly of Kv1.2 fits very well within the wider section of the Kv2.1 map ( Fig. 7 )."
18212012
STK11 affects KCNA2
| 1
STK11 inhibits KCNA2. 1 / 1
| 1
reach
"Interestingly, Kcna2, a Shaker channel, was also strongly up-regulated by LKB1 or AMPK deletion (XREF_FIG)."
25070369
SLC25A4 affects KCNA2
| 1
SLC25A4 binds KCNA2. 1 / 1
| 1
sparser
"Kv1.2 does not assemble efficiently in the absence of T1 in our hands."
11007484
RTN4 affects KCNA2
1 |
RTN4 binds KCNA2. 1 / 1
1 |
biogrid
No evidence text available
14592966
PKA affects KCNA2
| 1
PKA phosphorylates KCNA2 on S449. 1 / 1
| 1
sparser
"PKA phosphorylates Kv1.2 at S449 ( xref )."
21149544
NEU1 affects KCNA2
1 |
KCNA2 binds NEU1. 1 / 1
1 |
biogrid
No evidence text available
10896669
NAT affects KCNA2
| 1
NAT inhibits KCNA2. 1 / 1
| 1
reach
"The increase in NAT levels downregulates Kcna2, attenuating total voltage gated potassium currents, increasing excitability in DRG neurons and producing neuropathic pain symptoms."
26035178
MCF2L2 affects KCNA2
| 1
MCF2L2 activates KCNA2. 1 / 1
| 1
reach
"This increase contributed to CCI induced neuropathic induction and maintenance by transcriptionally activating Ehmt2 and subsequently epigenetic silencing of Oprm1 (which encodes MOR) and Kcna2 (which encodes Kv1.2) genes in the ipsilateral DRG."
28698219
Kbot21 affects KCNA2
| 1
KCNA2 binds Kbot21. 1 / 1
| 1
sparser
"The Kv2.1 potassium channel has a K360 equivalent to Q372 in Kv1.2 which interacts with R9 and K28 of Kbot21."
26398235
KCNA2-AS affects KCNA2
| 1
KCNA2-AS inhibits KCNA2. 1 / 1
| 1
reach
"In vivo and in vitro experiments have revealed that the overexpression of KCNA2-AS could decrease KCNA2 mRNA and protein content."
30323747
KCNA2 affects zinc finger protein
| 1
KCNA2 binds zinc finger protein. 1 / 1
| 1
reach
"Moreover, Kcna2 antisense RNA, a conserved long noncoding RNA (lncRNA) responsible for a voltage dependent potassium channel Kv1.2, largely located in first-order sensory neurons of the DRG is markedly increased in injured DRG through activation of myeloid zinc finger protein 1, a transcription factor that binds to the Kcna2 antisense RNA gene promoter, contributing to the development and maintenance of neuropathic pain [XREF_BIBR]."
25027291
KCNA2 affects sleep
| 1
KCNA2 inhibits sleep. 1 / 1
| 1
reach
"Transient knock-down of kcna2 reduces sleep in larval zebrafish."
28223099
KCNA2 affects reduced I K s
| 1
KCNA2 inhibits reduced I K s. 1 / 1
| 1
reach
"Ventricular Kcna2 AS expression increases in rats with CHF and contributes to reduced I K s, prolonged APs, and the occurrence of ventricular arrhythmias by silencing Kcna2."
29263036
KCNA2 affects pyraclofos
| 1
KCNA2 inhibits pyraclofos. 1 / 1
| 1
reach
"Knockdown of KCNA2 reduces the total voltage gated potassium current, resulting in increased excitability in neurons and neuropathic pain symptoms in rats [XREF_BIBR]."
25765076
KCNA2 affects Voltage_gated_ion_channels
| 1
Voltage_gated_ion_channels binds KCNA2. 1 / 1
| 1
sparser
"Then, by employing electrophysiological recordings as well as biochemical studies on ex vivo tissue and heterologous cells, they confirmed that the σ-1R's interaction with voltage-gated K + channel Kv1.2 contributes/participates in the behavioral response (locomotor sensitization) to cocaine."
23630466
KCNA2 affects TM
| 1
KCNA2 binds TM. 1 / 1
| 1
sparser
"The TM assembly of Kv1.2 fits very well within the wider section of the Kv2.1 map ( Fig. 7 )."
18212012
KCNA2 affects SLC25A4
| 1
SLC25A4 binds KCNA2. 1 / 1
| 1
sparser
"Kv1.2 does not assemble efficiently in the absence of T1 in our hands."
11007484
KCNA2 affects RTN4
1 |
RTN4 binds KCNA2. 1 / 1
1 |
biogrid
No evidence text available
14592966
KCNA2 affects Neuralgia
| 1
KCNA2 inhibits Neuralgia. 1 / 1
| 1
reach
"For example, Kcna2 antisense lncRNA is expressed in DRG neurons and causes or reduces NP through its ability to regulate the voltage dependent potassium channel, Kcna2, impacting neuronal excitability."
24904634
KCNA2 affects NREM sleep
| 1
KCNA2 inhibits NREM sleep. 1 / 1
| 1
reach
"Shaker is highly conserved across species, and mice lacking Kcna2, which codes for the alpha subunit of a Shaker like voltage dependent potassium channel (a.k.a. Kv1.2), also have reduced NREM sleep and die early [XREF_BIBR]."
20429945
KCNA2 affects NEU1
1 |
KCNA2 binds NEU1. 1 / 1
1 |
biogrid
No evidence text available
10896669
KCNA2 affects Kbot21
| 1
KCNA2 binds Kbot21. 1 / 1
| 1
sparser
"The Kv2.1 potassium channel has a K360 equivalent to Q372 in Kv1.2 which interacts with R9 and K28 of Kbot21."
26398235
KCNA2 affects KCNA4, and potassium(1+)
| 1
Potassium(1+) binds KCNA2 and KCNA4. 1 / 1
| 1
sparser
"We present here biochemical evidence that Kv1.4 and Kv1.2, two K+ channel subunits of the Shaker subfamily, co-assemble in rat brain."
8361540
KCNA2 affects KCNA4, and MME
| 1
KCNA2 binds KCNA4 and MME. 1 / 1
| 1
sparser
"Reciprocal coimmunoprecipitation experiments revealed that the beta-subunit polypeptides are associated with Kv1.2 and Kv1.4, but not Kv2.1, alpha-subunits."
7623158
KCNA2 affects ID1
| 1
ID1 binds KCNA2. 1 / 1
| 1
sparser
"Recently, de novo KCNA2 missense mutations were associated with epileptic encephalopathy, ataxia, variable ID xref , xref and other features reminiscent of those found in family PKMR82."
27457812
KCNA2 affects GFPT1
| 1
KCNA2 phosphorylates GFPT1. 1 / 1
| 1
sparser
"For instance, it was shown that HK2 and HK4 are capable of phosphorylating fructose directly to F-6-P: Katzen et al. determined the K m for glucose and fructose of rat HK2 to be 1.4×10 −4 M and 3.0×10 −3 M, respectively xref , and Malaisse et al. reported that 25% of hepatic fructose in rats is phosphorylated to F-6-P by HK4 xref ."
22096489
KCNA2 affects FYN
1 |
FYN binds KCNA2. 1 / 1
1 |
biogrid
No evidence text available
11149959
KCNA2 affects EE
| 1
KCNA2 activates EE. 1 / 1
| 1
reach
"De novo mutations in the homologous position in KCNA2 also cause EE in patients [XREF_BIBR]."
32316562
KCNA2 affects DLG1
1 |
DLG1 binds KCNA2. 1 / 1
1 |
hprd
No evidence text available
7477295
KCNA2 affects DEFB4A
| 1
DEFB4A binds KCNA2. 1 / 1
| 1
sparser
"The Kv1.2 subunit expressed alone is shown to fold into a native conformation as determined by high-affinity binding of 125I-labelled alpha-dendrotoxin, while co-expressed Kv1.2 and Kv beta 2 subunits co-assembled to form native-like oligomers."
14516746
KCNA2 affects CXCR4
| 1
CXCR4 binds KCNA2. 1 / 1
| 1
sparser
"The exosomes were validated using conformation-dependent ligand binding to the voltage-gated potassium channel Kv1.2 and the G-protein coupled receptor CXCR4 and used to determine the kinetic and equilibrium binding constants of BoNT/B to its receptor."
28432329
KCNA2 affects CNTNAP1
1 |
KCNA2 binds CNTNAP1. 1 / 1
1 |
biogrid
No evidence text available
14592966
KCNA2 affects CNTN2
| 1 1
CNTN2 binds KCNA2. 1 / 1
| 1 1
sparser
"As previously reported for Caspr2 ( xref ), we could not detect any interaction between TAG-1 and Kv1.2 in transfected cells (unpublished data), suggesting that the association between TAG-1 and these channels observed in rat brain occurs indirectly, and probably requires Caspr2 and additional unknown adaptor proteins."
12963709
KCNA2 affects CAMLG
1 |
CAMLG binds KCNA2. 1 / 1
1 |
biogrid
No evidence text available
25416956
KCNA2 affects Ala-Pro
| 1
KCNA2 inhibits Ala-Pro. 1 / 1
| 1
reach
"Conversely, Kcna2 overexpression in the heart significantly attenuated the CHF induced decreases in the I Ks, AP prolongation, and ventricular arrhythmias."
29263036
KCNA2 affects .8
| 1
KCNA2 decreases the amount of .8. 1 / 1
| 1
reach
"Kcna2 antisense RNA dramatically decreased Kcna2 mRNA and protein expression, but not Kcna1, Kcna4, or Na1.8 expression (XREF_FIG)."
23792947
KCNA1 affects KCNA2, KCNA3, and voltage-gated potassium channel
| 1
KCNA1 binds KCNA2, KCNA3, and voltage-gated potassium channel. 1 / 1
| 1
sparser
"Recognition of interactions of kappa-Hefutoxin1 with the voltage-gated potassium channels, Kv1.1, Kv1.2, and Kv1.3, was studied by 3D-Dock software package."
18076029
KCNA1 affects KCNA2, KCNA3, and MTX1
| 1
KCNA1 binds KCNA2, KCNA3, and MTX1. 1 / 1
| 1
sparser
"In this study, by means of the Brownian dynamics (BD) method ( Ermak and McCammon, 1978 ), the association of MTX (all of the 35 available structures in the Protein Data Bank; 1TXM) with Kv1.1, Kv1.2, and Kv1.3 was simulated."
12414674
Ischemia affects KCNA2
| 1
Ischemia phosphorylates KCNA2. 1 / 1
| 1
sparser
"The main neuroprotective mechanisms of VEGF include: (1) modulation of the phosphatidylinositol 3'-kinase (PI3K)/Akt/nuclear factor-kappaB signaling pathway, inhibition of caspase-3 activity, and reduction of ischemic neuronal apoptosis; (2) inhibition of outward delayed rectifier potassium channel currents and increase of ischemia-induced tyrosine phosphorylation of Kv1.2 potassium channel proteins via activation of the PI3K pathway; and (3) enhancement of proliferation and migration of neural progenitors in the subventricular zone and improvement of striatal neurogenesis and maturation of newborn neurons in adult rat brains after stroke."
15573409
IK affects KCNA2, and KCNB1
| 1
IK binds KCNA2 and KCNB1. 1 / 1
| 1
sparser
"Kv1.2 and Kv2.1 were associated with IK(DR); Slo and KCNN4 were associated with IK(Ca); and Kv1.4 and Kv4.3 were associated with Ito."
18505444
ID1 affects KCNA2
| 1
ID1 binds KCNA2. 1 / 1
| 1
sparser
"Recently, de novo KCNA2 missense mutations were associated with epileptic encephalopathy, ataxia, variable ID xref , xref and other features reminiscent of those found in family PKMR82."
27457812
Histone affects KCNA2
| 1
Histone inhibits KCNA2. 1 / 1
| 1
reach
"For example, G9a triggered histone methylation and endogenous long non coding Kcna2 antisense RNA are involved in nerve injury induced Kcna2 silencing in the injured DRG."
29056068
GNRH1 affects KCNA2
| 1
GNRH1 decreases the amount of KCNA2. 1 / 1
| 1
reach
"Moreover, our transcriptome study implies that a pulsatile GnRH application downregulates the expression of Kcna2 (K v 1.2) and Kcnh6 (ether-a-go-go), while it upregulates Kcnk10 (outward rectifier) and Na + / Ca 2+ exchanger Slc24a3, indicating that GnRHR may indirectly be involved in regulation of cell excitability."
28649232
GNPTAB affects KCNA1, and KCNA2
| 1
GNPTAB binds KCNA1 and KCNA2. 1 / 1
| 1
sparser
"A complete random assembly of Kv1.1- and Kv1.2-subunits into functional channels would imply that 6.25% of all channels should be homomeric Kv1.1, another 6.25% homomeric Kv1.2 channels, whereas the remaining complexes should consist of heteromeric Kv1.1/1.2 channels in different stoichiometry."
12944270
FYN affects KCNA2
1 |
FYN binds KCNA2. 1 / 1
1 |
biogrid
No evidence text available
11149959
DRG affects KCNA2, MZF1, and SLC22A18AS
| 1
SLC22A18AS binds MZF1, KCNA2, and DRG. 1 / 1
| 1
sparser
"These in vivo findings suggest that peripheral nerve injury increases DRG MZF1 expression, allowing the binding of more MZF1 to the promoter region of Kcna2 antisense gene in the injured DRG neurons."
23792947
DLG1 affects KCNA2
1 |
DLG1 binds KCNA2. 1 / 1
1 |
hprd
No evidence text available
7477295
DEFB4A affects KCNA2
| 1
DEFB4A binds KCNA2. 1 / 1
| 1
sparser
"The Kv1.2 subunit expressed alone is shown to fold into a native conformation as determined by high-affinity binding of 125I-labelled alpha-dendrotoxin, while co-expressed Kv1.2 and Kv beta 2 subunits co-assembled to form native-like oligomers."
14516746
CXCR4 affects KCNA2
| 1
CXCR4 binds KCNA2. 1 / 1
| 1
sparser
"The exosomes were validated using conformation-dependent ligand binding to the voltage-gated potassium channel Kv1.2 and the G-protein coupled receptor CXCR4 and used to determine the kinetic and equilibrium binding constants of BoNT/B to its receptor."
28432329
CTTN affects KCNA2, and cya
| 1
CTTN binds KCNA2 and cya. 1 / 1
| 1
sparser
"The result showed that EF triggered Kv1.2 channel binding to scaffolding protein cortactin (Fig. xref )."
26580832
CNTNAP2 affects KCNA1, KCNA2, and KCNAB2
1 |
CNTNAP2 binds KCNA1, KCNA2, and KCNAB2. 1 / 1
1 |
hprd
No evidence text available
10624965
CNTNAP1 affects KCNA2
1 |
KCNA2 binds CNTNAP1. 1 / 1
1 |
biogrid
No evidence text available
14592966
CNTN2 affects KCNA2
| 1 1
CNTN2 binds KCNA2. 1 / 1
| 1 1
sparser
"As previously reported for Caspr2 ( xref ), we could not detect any interaction between TAG-1 and Kv1.2 in transfected cells (unpublished data), suggesting that the association between TAG-1 and these channels observed in rat brain occurs indirectly, and probably requires Caspr2 and additional unknown adaptor proteins."
12963709
CNTN2 affects CNTNAP2, ERVK-18, KCNA1, KCNA2, and voltage-gated potassium channel
| 1
CNTNAP2 binds CNTN2, ERVK-18, KCNA1, KCNA2, and voltage-gated potassium channel. 1 / 1
| 1
sparser
"Contactin-2 expressed on Schwann cells and oligodendroglia interacts with the transmembrane protein CaspR2 and Contactin-2 on the axonal membrane to maintain the voltage-gated potassium channels Kv1.1 and Kv1.2 in juxtaparanodes of myelinated axons ( xref ; xref )."
24646365
CNTN1 affects CNTN6, CNTNAP1, KCNA2, KCNAB1, and RTN4
1 |
RTN4 binds CNTN1, CNTN6, KCNA2, KCNAB1, and CNTNAP1. 1 / 1
1 |
hprd
No evidence text available
14592966
CAMLG affects KCNA2
1 |
CAMLG binds KCNA2. 1 / 1
1 |
biogrid
No evidence text available
25416956
BZW1 affects KCNA2, S100A6, and TP63
| 1
S100A6 binds TP63, BZW1, and KCNA2. 1 / 1
| 1
sparser
"P63 does not bind the KCNA2-2, S100A6 and BZW1 sites, and weakly binds LEPRE1, KCNA2-1."
18495754
AS affects KCNA2, and MZF1
| 1
MZF1 binds KCNA2 and AS. 1 / 1
| 1
sparser
"Peripheral nerve injury up-regulates the expression of MZF1 in the DRG and increases the binding activity of MZF1 to the promoter region of the Kv1.2 AS RNA gene [ xref ]."
25630025
AMPK affects KCNA2
| 1
AMPK inhibits KCNA2. 1 / 1
| 1
reach
"Interestingly, Kcna2, a Shaker channel, was also strongly up-regulated by LKB1 or AMPK deletion (XREF_FIG)."
25070369
AHP amplitude affects KCNA2
| 1
AHP amplitude inhibits KCNA2. 1 / 1
| 1
reach
"The higher expression of Kcna2 (Kv1.2), Kcnab1 (Kv.1.3), and Hcn1 detected in striatal Pvalb expressing cells compared to their cortical counterparts can explain their latency to first spike (delayed firing) (Kcna2), reduced AHP amplitude (Kcna2 and Kcnab1), increased rheobase (Kcnab1), and lower input resistance and membrane time constant (Hcn1)."
30134177