INDRA statements for CACNA1S

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
CACNA1S affects calcium(2+)
2 | 5
CACNA1S activates calcium(2+).
| 4
CACNA1S activates calcium(2+). 3 / 3
| 3
reach
"We hypothesize that Cacna1s contributes to light adaptation by permeating calcium."
24519419
reach
"Compared with previous studies, we reported two new Ca 2+ channels, PMCA1 and CACNA1S that were related to Se deficiency and Ca 2+ leak but found that RyRs were not involved in the Se deficiency induced Ca 2+ leak."
27557522
reach
"Therefore, redox regulated SERCA, CACNA1S, TRPC1, and TRPC3 channels by SelW may be involved in the process of Se deficiency induced Ca 2+ leak."
27557522
CACNA1S-R900S activates calcium(2+). 1 / 1
| 1
reach
"We speculate that the CACNA1S R900S mutation produces an I gp in Ca v 1.1, causing skeletal muscle periodic paralysis, although functional studies are necessary to confirm this.We observed that the CACNA1S R900S mutation carriers have different penetrance in males and females."
26433613
CACNA1S increases the amount of calcium(2+).
| 1
Mutated CACNA1S increases the amount of calcium(2+). 1 / 1
| 1
reach
"The discovery of single missense CACNA1S mutations in humans with HPP-1 which still allow expression of a full-length Ca v 1.1 alpha1 subunit protein suggested that changes in channel gating or channel expression on the cell surface may account for altered skeletal muscle function."
20213496
TnT3 affects CACNA1S
| 6
TnT3 inhibits CACNA1S.
| 2
TnT3 inhibits CACNA1S. 2 / 2
| 2
reach
"TnT3 downregulation or overexpression decreased or increased, respectively, Cacna1s promoter activity, and the effect was ablated by truncating the TnT3 nuclear localization sequence."
26892246
reach
"These results indicate that (i) TnT3 enhances Cacna1s promoter activity, (ii) TnT3 knockdown directly reduces Cacna1s promoter activity in skeletal muscle, and (iii) preventing TnT3 's nuclear translocation inhibits its effect on Cacna1s transcription."
26892246
TnT3 binds CACNA1S.
| 2
CACNA1S binds TnT3. 2 / 2
| 2
reach
"Further, we mapped the Cacna1s promoter region and established the consensus sequence for TnT3 binding to Cacna1s promoter."
26892246
reach
"We reported that increased Ca v beta 1a expression decreases Ca v 1.1 expression with aging [XREF_BIBR], which may be explained by Ca v beta 1a 's interference with TnT3 binding to Cacna1s, the gene encoding Ca v 1.1 (unpublished data)."
25981458
TnT3 decreases the amount of CACNA1S.
| 1
TnT3 decreases the amount of CACNA1S. 1 / 1
| 1
reach
"Thus, TnT3 fragmentation impairs Cacna1s transcription and Cav1.1 expression, and BDA-410-mediated calpain inhibition rescues Cav1.1 levels in skeletal muscle from aging sedentary mice."
26892246
TnT3 activates CACNA1S.
| 1
TnT3 activates CACNA1S. 1 / 1
| 1
reach
"These results indicate that (i) TnT3 enhances Cacna1s promoter activity, (ii) TnT3 knockdown directly reduces Cacna1s promoter activity in skeletal muscle, and (iii) preventing TnT3 's nuclear translocation inhibits its effect on Cacna1s transcription."
26892246
CACNA1S affects TnT3
| 5
CACNA1S increases the amount of TnT3.
| 3
CACNA1S increases the amount of TnT3. 3 / 3
| 3
reach
"TnT3 regulates Cacna1s transcription and Cav1.1 expression."
26892246
reach
"To test whether TnT3 regulates Cacna1s transcription, we knocked down TnT3 in mouse skeletal muscle invivo to determine whether Cav1.1 expression depends on TnT3 regulation of Cacna1s."
26892246
reach
"To examine the hypothesis that TnT3 regulates Cacna1s transcription, we performed a dual luciferase assay using a construct in which the Cacna1s promoter drives the firefly luciferase reporter gene (Zheng etal., 2002a)."
26892246
CACNA1S binds TnT3.
| 2
CACNA1S binds TnT3. 2 / 2
| 2
reach
"Further, we mapped the Cacna1s promoter region and established the consensus sequence for TnT3 binding to Cacna1s promoter."
26892246
reach
"We reported that increased Ca v beta 1a expression decreases Ca v 1.1 expression with aging [XREF_BIBR], which may be explained by Ca v beta 1a 's interference with TnT3 binding to Cacna1s, the gene encoding Ca v 1.1 (unpublished data)."
25981458
Rv2463 affects CACNA1S
| 4
Rv2463 increases the amount of CACNA1S.
| 3
Rv2463 increases the amount of CACNA1S. 3 / 3
| 3
reach
"To that end, we scored for Rv2463 and M. tb mediated CACNA1S expression upon ROS inhibition."
25915405
reach
"M. tb and Rv2463 upregulate CACNA1S expression in macrophages."
25915405
reach
"As shown in (XREF_FIG), Rv2463 increased the expression of CACNA1S in a dose and time dependent manner."
25915405
Rv2463 activates CACNA1S.
| 1
Rv2463 activates CACNA1S. 1 / 1
| 1
reach
"This indicated that the modulation of CACNA1S by Rv2463 was specific."
25915405
CACNA1S affects FERMT2
| 1 3
CACNA1S inhibits FERMT2.
| 2
CACNA1S inhibits FERMT2. 2 / 2
| 2
reach
"This strongly suggests one function of CACN-1 may be to negatively regulate MIG-2 activity at the end of DTC migration."
20188721
reach
"We predict that a function of cacn-1 is to reduce activity of mig-2 post-transcriptionally, which thereby leads to the cessation of DTC migration at the end of larval development."
20188721
CACNA1S decreases the amount of FERMT2.
| 1
CACNA1S decreases the amount of FERMT2. 1 / 1
| 1
reach
"Given these results, we speculated CACN-1 might normally function to suppress mig-2 transcription in late L4 and adult animals."
20188721
CACNA1S binds FERMT2.
| 1
CACNA1S binds FERMT2. 1 / 1
| 1
sparser
"We present genetic evidence that suggests cacn-1 interacts genetically with the Rac GTPase mig-2 to regulate distal tip cell pathfinding."
20188721
Ced-10 affects CACNA1S
| 2 1
CACNA1S binds ced-10. 2 / 2
| 1 1
sparser
"We also tested the genetic interaction between ced-10 and cacn-1 by treating the progeny of ced-10 (n3417/+) animals with cacn-1 RNAi."
20188721
reach
"We also tested the genetic interaction between ced-10 and cacn-1 by treating the progeny of ced-10 (n3417/+) animals with cacn-1 RNAi."
20188721
CACNA1S binds FERMT3, ABL1, and ced-10. 1 / 1
| 1
sparser
"The abl-1 /Abl kinase, which interacts with ABI-1, a cytoskeletal regulatory protein of the WASP-family verprolin-homologous (WAVE) protein complex, can suppress ced mutant phenotypes in the DTC. xref Mutations in the C. elegans homolog of the Drosophila Cactus binding protein Cactin/CACN-1 enhanced the ced-10 mutant phenotypes. xref Although the molecular mechanisms governing the interactions of CACN-1 or ABL-1 with CED-10 or MIG-2 have not been deciphered, the genetic data support potential roles for these molecules in modulating Rac signaling between adhesion and cytoskeletal dynamics."
23559979
STAC3 affects CACNA1S
| 2 1
STAC3 binds CACNA1S.
| 2
RYR1 binds CACNA1S and STAC3. 1 / 1
| 1
sparser
"Three genes, RYR1 , CACNA1S , and STAC3 , have been associated with MH susceptibility."
31016048
RYR1 binds CACNA1S, STAC3, and MSTN. 1 / 1
| 1
sparser
"Via DNA samples, genetic testing aims to find mutations in the genes responsible for contraction-excitation coupling and calcium regulation in skeletal muscle, namely RYR1 , CACNA1S , and STAC3 , that have been associated with MH [5] ."
27555149
STAC3 activates CACNA1S.
| 1
STAC3 activates CACNA1S. 1 / 1
| 1
reach
"A recent study by Polster et al. demonstrates that STAC3 can target the DHPRalpha1 subunit CACNA1S to the plasma membrane of tsA201 cells [XREF_BIBR]."
27073615
SELENOW affects CACNA1S
| 3
SELENOW inhibits CACNA1S.
| 1
SELENOW inhibits CACNA1S. 1 / 1
| 1
reach
"In embryos, SelW deficiency reduced SLC8A, CACNA1S, ORA1, TRPC1, and TRPC3 Ca 2+ channels."
27557522
SELENOW decreases the amount of CACNA1S.
| 1
SELENOW decreases the amount of CACNA1S. 1 / 1
| 1
reach
"In chicken myoblasts, SelW deficiency decreased the levels of RyR1, RyR3, CACNA1S, SERCA1, TRPC1, TRPC3, STIM1, SERCA1, and ORAI1 (P < 0.05) but did not influence SLC8A1 or PMCA Ca 2+ channels (P> 0.05)."
27557522
SELENOW activates CACNA1S.
| 1
SELENOW activates CACNA1S. 1 / 1
| 1
reach
"SelW deficiency reduced the response of RyR1 to ryanodine, increased the sensitivity of SERCA to thapsigargin, and CACNA1S to Cd, or sustained and delayed the effect of Ni on NCX."
27557522
PRKACA affects CACNA1S
3 |
PRKACA phosphorylates CACNA1S on S1617. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKACA phosphorylates CACNA1S on S1575. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKACA phosphorylates CACNA1S on S687. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CACNA1S affects ced-10
| 2 1
CACNA1S binds ced-10. 2 / 2
| 1 1
sparser
"We also tested the genetic interaction between ced-10 and cacn-1 by treating the progeny of ced-10 (n3417/+) animals with cacn-1 RNAi."
20188721
reach
"We also tested the genetic interaction between ced-10 and cacn-1 by treating the progeny of ced-10 (n3417/+) animals with cacn-1 RNAi."
20188721
CACNA1S binds FERMT3, ABL1, and ced-10. 1 / 1
| 1
sparser
"The abl-1 /Abl kinase, which interacts with ABI-1, a cytoskeletal regulatory protein of the WASP-family verprolin-homologous (WAVE) protein complex, can suppress ced mutant phenotypes in the DTC. xref Mutations in the C. elegans homolog of the Drosophila Cactus binding protein Cactin/CACN-1 enhanced the ced-10 mutant phenotypes. xref Although the molecular mechanisms governing the interactions of CACN-1 or ABL-1 with CED-10 or MIG-2 have not been deciphered, the genetic data support potential roles for these molecules in modulating Rac signaling between adhesion and cytoskeletal dynamics."
23559979
CACNA1S affects RAC
| 2 1
CACNA1S binds RAC.
| 2
RAC binds CACNA1S. 1 / 1
| 1
sparser
"In order to investigate the genetic interaction between cacn-1 and Rac GTPases, we treated mutant animals expressing a strong loss of function allele ced-10(n1993), and two different null alleles of mig-2, mig-2(mu28) and mig-2 ( gm38mu133), with cacn-1 RNAi."
20188721
RAC binds CACNA1S and DTC. 1 / 1
| 1
sparser
"CACN-1 interacts genetically with the Rac GTPases to control DTC pathfinding."
20188721
CACNA1S activates RAC.
| 1
CACNA1S activates RAC. 1 / 1
| 1
reach
"Our genetic interaction experiments suggest CACN-1 modulates Rac GTPase signaling to control DTC pathfinding."
20188721
CACNA1S affects BVES
| 3
CACNA1S inhibits BVES.
| 2
CACNA1S inhibits BVES. 2 / 2
| 2
reach
"These results suggest an important function of CACN-1 is to prevent accumulation of POP-1 in the nucleus, perhaps through stimulating export of POP-1 or modulating POP-1 expression."
24999833
reach
"These results suggest CACN-1 negatively regulates POP-1 by targeting both POP-1 and LIT-1 expression and/or localization."
24999833
CACNA1S decreases the amount of BVES.
| 1
Modified CACNA1S decreases the amount of BVES. 1 / 1
| 1
reach
"Loss of CACN-1 did not cause a significant change in the overall POP-1 protein levels (control RNAi to cacn-1 RNAi ratio : 0.90, n = 2)."
24999833
CACNA1S affects 1,3-di(p-tolyl)carbodiimide
| 3
CACNA1S inhibits 1,3-di(p-tolyl)carbodiimide. 2 / 2
| 2
reach
"Comparison of control RNAi and cacn-1 RNAi treated animals demonstrated that loss of cacn-1 also causes other significant defects in DTC migration including wandering and inappropriate extra turns (XREF_TABLE)."
20188721
reach
"DTC pathfinding defects in both pak-1 (ok448) and pak-1 (tm403), and to a greater extent max-2 (nv162) and max-2 (cy2), are strongly enhanced by loss of cacn-1, suggesting that cacn-1 works in parallel to pak-1 and max-2 to control DTC migration (XREF_TABLE)."
20188721
CACNA1S activates 1,3-di(p-tolyl)carbodiimide. 1 / 1
| 1
reach
"Our genetic interaction experiments suggest CACN-1 modulates Rac GTPase signaling to control DTC pathfinding."
20188721
Selenium atom affects CACNA1S
| 2
Selenium atom inhibits CACNA1S.
| 1
Selenium atom inhibits CACNA1S. 1 / 1
| 1
reach
"Se deficiency induced the decrease of SERCA, SLC8A, CACNA1S, ORAI1, STIM1, TRPC1, and TRPC3 (P < 0.05) and the increase of PMCA (P < 0.05), but it did not influence RyR1 or RyR3 (P> 0.05)."
27557522
Selenium atom decreases the amount of CACNA1S.
| 1
Selenium atom decreases the amount of CACNA1S. 1 / 1
| 1
reach
"The results showed that Se deficiency decreased the expression of SLC8A, CACNA1S, ORAI1, STIM1, SERCA, TRPC1, and TRPC3; increased the expression of PMCA; and did not influence RyR1 and RyR3 levels."
27557522
Calcium(2+) affects CACNA1S
| 2
Calcium(2+) increases the amount of CACNA1S.
| 1
Calcium(2+) increases the amount of CACNA1S. 1 / 1
| 1
reach
"This indicated that calcium homeostasis differentially regulated Rv2463 and M. tb induced CACNA1S expression."
25915405
Calcium(2+) activates CACNA1S.
| 1
Calcium(2+) activates CACNA1S. 1 / 1
| 1
reach
"Enhanced mis splicing also occurred for Ryr2, which regulates calcium release from the sarcoplasmic reticulum and RYR2 mutations cause catecholaminergic polymorphic ventricular tachycardia, and Cacna1s, which was recently shown to be mis spliced in cardiac and skeletal muscle leading to aberrant gating of this Ca (V) 1.1 calcium channel."
24293317
SRI affects CACNA1S
1 1 |
SRI binds CACNA1S. 2 / 2
1 1 |
biogrid
No evidence text available
9668070
hprd
No evidence text available
9668070
RAC affects CACNA1S
| 2
RAC binds CACNA1S. 1 / 1
| 1
sparser
"In order to investigate the genetic interaction between cacn-1 and Rac GTPases, we treated mutant animals expressing a strong loss of function allele ced-10(n1993), and two different null alleles of mig-2, mig-2(mu28) and mig-2 ( gm38mu133), with cacn-1 RNAi."
20188721
RAC binds CACNA1S and DTC. 1 / 1
| 1
sparser
"CACN-1 interacts genetically with the Rac GTPases to control DTC pathfinding."
20188721
Met-His affects CACNA1S
| 2
Met-His binds CACNA1S. 2 / 2
| 2
reach
"There was a small but significant difference observed with this comparison (p = 0.02), providing evidence for association between MH and CACNA1S."
19825159
reach
"Via DNA samples, genetic testing aims to find mutations in the genes responsible for contraction excitation coupling and calcium regulation in skeletal muscle, namely RYR1, CACNA1S, and STAC3, that have been associated with MH [5]."
27555149
DEGs affects CACNA1S
| 2
CACNA1S binds DEGs. 1 / 1
| 1
sparser
"In the PPI network for ADRA1D , CACNA1S and the DEGs interacting with them, prohibitin ( PHB ), oxytocin receptor ( OXTR ), collapsin response mediator protein 1 ( CRMP1 ) and dihydropyrimidinase like 2 ( DPYSL2 ) had interaction relationships with both ADRA1D and CACNA1S . To conclude, the present study revealed that NDUFV2 , PHB , OXTR , CRMP1 and DPYSL2 may have key roles in the effect of inflammation on neurotransmission of VSMC."
28413470
CACNA1S binds ADRA1D and DEGs. 1 / 1
| 1
sparser
"In the PPI network for ADRA1D , CACNA1S and the DEGs interacting with these components, PHB , OXTR , CRMP1 and DPYSL2 were revealed to have interaction relationships with both ADRA1D and CACNA1S ."
28413470
CACNA1S affects sodium atom
| 2
CACNA1S activates sodium atom. 2 / 2
| 2
reach
"Because of the higher frequency of attacks in SPP patients with mutations compared with SPP patients without mutation, we hypothesize that the mutations in CACNA1S and SCN4A increase the susceptibility to paralysis.Mutations in CACNA1S and SCN4A create an aberrant gating pore current, which predisposes the membrane to depolarization during hypokalemia and consequently inactivates the Na + channel."
21841462
reach
"Familial forms of hypoPP are caused by SCN4A (20%) and CACNA1S (60%) mutations of positively charged residues in the channel voltage sensor that create an aberrant permeation pathway for H + or Na + ions, resulting in depolarizing cation leak currents named gating pore currents."
27242528
CACNA1S affects SRI
1 1 |
SRI binds CACNA1S. 2 / 2
1 1 |
biogrid
No evidence text available
9668070
hprd
No evidence text available
9668070
CACNA1S affects SLM2
| 2
CACNA1S increases the amount of SLM2.
| 1
Modified CACNA1S increases the amount of SLM2. 1 / 1
| 1
reach
"Loss of CACN-1 reduces LIT-1 expression levels."
24999833
CACNA1S binds SLM2.
| 1
CACNA1S binds SLM2. 1 / 1
| 1
reach
"To further investigate a possible interaction between CACN-1 and LIT-1, we next determined the effect of cacn-1 RNAi on LIT-1 expression pattern and protein level."
24999833
CACNA1S affects POPTOP reporter
| 2
CACNA1S decreases the amount of POPTOP reporter. 2 / 2
| 2
reach
"The increase in POPTOP reporter expression induced by knockdown of both CACN-1 and LIT-1 protein was also significantly greater than the enhancement by knockdown of CACN-1 alone (lit-1 (ne1991) P = 0.0021; lit-1 (or131) P = 0.0009)."
24999833
reach
"While RNAi knockdown of CACN-1 alone caused a 7-fold increase in POPTOP reporter expression from wild type levels, cacn-1 RNAi in combination with the temperature sensitive alleles augmented expression of the POPTOP reporter 10-fold compared to wild type levels (lit-1 (ne1991) P < 0.0001, n = 33; lit-1 (or131) P < 0.0001, n = 36; XREF_FIG)."
24999833
CACNA1S affects POPTOP
| 2
CACNA1S decreases the amount of POPTOP. 2 / 2
| 2
reach
"CACN-1 negatively regulates POPTOP expression in the somatic gonad."
24999833
reach
"LIT-1 and CACN-1 both negatively regulate POPTOP expression."
24999833
CACNA1S affects Met-His
| 2
Met-His binds CACNA1S. 2 / 2
| 2
reach
"There was a small but significant difference observed with this comparison (p = 0.02), providing evidence for association between MH and CACNA1S."
19825159
reach
"Via DNA samples, genetic testing aims to find mutations in the genes responsible for contraction excitation coupling and calcium regulation in skeletal muscle, namely RYR1, CACNA1S, and STAC3, that have been associated with MH [5]."
27555149
CACNA1S affects HypoPP
| 2
CACNA1S activates HypoPP. 2 / 2
| 2
reach
"This study identifies a novel Arg528Gly mutation in the CACNA1S gene that causes HypoPP in a Chinese family, expands the spectrum of mutations causing HypoPP, and demonstrates a gender difference in the penetrance of the disease."
15726306
reach
"HypoPP is caused by mutations in CACNA1S, which encodes the alpha-subunit of the calcium channel Ca v 1.1, and SCN4A, which encodes the alpha-subunit of sodium channel Na v 1.4."
26433613
CACNA1S affects DEGs
| 2
CACNA1S binds DEGs. 1 / 1
| 1
sparser
"In the PPI network for ADRA1D , CACNA1S and the DEGs interacting with them, prohibitin ( PHB ), oxytocin receptor ( OXTR ), collapsin response mediator protein 1 ( CRMP1 ) and dihydropyrimidinase like 2 ( DPYSL2 ) had interaction relationships with both ADRA1D and CACNA1S . To conclude, the present study revealed that NDUFV2 , PHB , OXTR , CRMP1 and DPYSL2 may have key roles in the effect of inflammation on neurotransmission of VSMC."
28413470
CACNA1S binds ADRA1D and DEGs. 1 / 1
| 1
sparser
"In the PPI network for ADRA1D , CACNA1S and the DEGs interacting with these components, PHB , OXTR , CRMP1 and DPYSL2 were revealed to have interaction relationships with both ADRA1D and CACNA1S ."
28413470
CACNA1S affects Calcium_channels, and Sodium_channels
| 2
Calcium_channels binds Sodium_channels and CACNA1S. 2 / 2
| 2
sparser
"HypoPP is associated with mutations in calcium channel ( CACNA1S ; 60% of kindreds) and sodium channel ( SCN4A ; 20% of kindreds) genes. xref , xref , xref , xref , xref The clinical presentation is identical for patients with HypoPP caused by calcium or sodium channel mutations because homologous gene defects of either channel cause an anomalous leakage current, which is active at the resting potential and produces susceptibility to paradoxical depolarization of the fiber and inexcitability in the setting of low extracellular K + (2.5 to 3.5 Meq/L). xref , xref "
29125635
sparser
"HypoPP is associated with mutations in calcium channel ( CACNA1S ; 60% of kindreds) and sodium channel ( SCN4A ; 20% of kindreds) genes. xref – xref The clinical presentation is identical for patients with HypoPP caused by calcium or sodium channel mutations because homologous gene defects of either channel cause an anomalous leakage current, which is active at the resting potential and produces susceptibility to paradoxical depolarization of the fiber and inexcitability in the setting of low extracellular K + (2.5 to 3.5 Meq/L). xref , xref "
29125635
Tb affects CACNA1S
| 1
Tb increases the amount of CACNA1S. 1 / 1
| 1
reach
"M. tb and Rv2463 upregulate CACNA1S expression in macrophages."
25915405
Ryanodine receptor affects CACNA1S
| 1 1
CACNA1S binds ryanodine receptor. 1 / 1
| 1 1
sparser
"In skeletal muscle, the CACNA1S containing VDCCs interact with ryanodine receptors."
27471951
Nifedipine affects CACNA1S
| 1
Nifedipine activates CACNA1S. 1 / 1
| 1
reach
"Cacna1s, an L-type calcium channel that is targeted by Nifedipine, was validated as expressed in ECs by Q-PCR (XREF_SUPPLEMENTARY)."
24767999
Hsa-miR-26b-5p affects CACNA1S
1 |
Transcriptionally active hsa-miR-26b-5p decreases the amount of CACNA1S. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19088304
Cyclosporin A affects CACNA1S
| 1
Cyclosporin A inhibits CACNA1S. 1 / 1
| 1
reach
"Furthermore, CsA prevented the down-regulation of Scn4a and Cacna1s induced by voluntary running since no difference was found between Mdx+ wheel+ CsA mice and Mdx+ CsA mice."
30142334
Cacn-1 RNAi affects CACNA1S
| 1
Cacn-1 RNAi activates CACNA1S. 1 / 1
| 1
reach
"In addition, cacn-1 (tm3126) animals treated with cacn-1 RNAi exhibit more severe and penetrant DTC migration defects than cacn-1 (tm3126) control treated animals (XREF_FIG and XREF_TABLE)."
20188721
YWHAQ affects CACNA1S
1 |
YWHAQ binds CACNA1S. 1 / 1
1 |
biogrid
No evidence text available
20618440
TRAF6 affects CACNA1S
| 1
TRAF6 decreases the amount of CACNA1S. 1 / 1
| 1
reach
"However, knockdown of either TRAF6 or IRAK1 significantly inhibited Rv2463 mediated but not M. tb mediated CACNA1S expression."
25915405
STIM2 affects CACNA1S
| 1
STIM2 decreases the amount of CACNA1S. 1 / 1
| 1
reach
"Internal calcium sensors STIM1 and STIM2 negatively regulate CACNA1S expression."
25915405
STIM1 affects CACNA1S
| 1
STIM1 decreases the amount of CACNA1S. 1 / 1
| 1
reach
"Internal calcium sensors STIM1 and STIM2 negatively regulate CACNA1S expression."
25915405
SLM2 affects CACNA1S
| 1
CACNA1S binds SLM2. 1 / 1
| 1
reach
"To further investigate a possible interaction between CACN-1 and LIT-1, we next determined the effect of cacn-1 RNAi on LIT-1 expression pattern and protein level."
24999833
Rv3416 affects CACNA1S
| 1
Rv3416 increases the amount of CACNA1S. 1 / 1
| 1
reach
"However, unlike Rv2463, Rv3416 did not modulate CACNA1S expression on macrophages."
25915405
Reactive Oxygen Species affects CACNA1S
| 1
Reactive Oxygen Species decreases the amount of CACNA1S. 1 / 1
| 1
reach
"As shown in (XREF_FIG), inhibiting ROS further enhanced CACNA1S expression upon Rv2463 stimulation and M. tb infection."
25915405
RNAi affects CACNA1S
| 1
RNAi inhibits CACNA1S. 1 / 1
| 1
reach
"Depletion of CACN-1 by RNAi leads to an increase in POPTOP activation in the developing uterus and spermatheca of L4 animals."
24999833
RIMS2 affects CACNA1S
1 |
CACNA1S binds RIMS2. 1 / 1
1 |
hprd
No evidence text available
14660679
Phe-Asp affects CACNA1S
| 1
Phe-Asp inhibits CACNA1S. 1 / 1
| 1
reach
"Unlike CACNA1A, which closely regulates the nervous system, CACNA1S suppressed by FD is associated with photoreception and thermoregulation XREF_BIBR, XREF_BIBR."
24632812
PRKAC affects CACNA1S
1 |
Kinase-active PRKAC activates CACNA1S. 1 / 1
1 |
bel
"In skeletal muscle, voltage-dependent potentiation of L-type Ca(2+) channel (Ca(V)1.1) activity requires phosphorylation by cyclic AMP-dependent protein kinase (PKA) anchored via an A kinase-anchoring protein (AKAP15)."
11733497
PPP2R2A affects CACNA1S
1 |
CACNA1S binds PPP2R2A. 1 / 1
1 |
biogrid
No evidence text available
22863883
PDZD3 affects CACNA1S
1 |
CACNA1S binds PDZD3. 1 / 1
1 |
biogrid
No evidence text available
25416956
Nav1.4 gain function mutation affects CACNA1S
| 1
Nav1.4 gain function mutation activates CACNA1S. 1 / 1
| 1
eidos
"Basically , a Nav1.4 gain of function mutation results in myotonia , hyperPP and hypoPP ; however , some defects predispose to myotonia , while others increase susceptibility to PP ."
32276507
NAC affects CACNA1S
| 1
NAC activates CACNA1S. 1 / 1
| 1
reach
"NAC treatment increased RyR1, CACNA1S, TRPC1, and TRPC3 to a normal or higher level (P < 0.05) and alleviated the effect of SelW deficiency on RyR3, SERCA, and STIM1 (P < 0.05)."
27557522
KCNQ1OT1 affects CACNA1S
| 1
CACNA1S binds KCNQ1OT1. 1 / 1
| 1
sparser
"To further investigate a possible interaction between CACN-1 and LIT-1, we next determined the effect of cacn-1 RNAi on LIT-1 expression pattern and protein level."
24999833
IRAK1 affects CACNA1S
| 1
IRAK1 decreases the amount of CACNA1S. 1 / 1
| 1
reach
"However, knockdown of either TRAF6 or IRAK1 significantly inhibited Rv2463 mediated but not M. tb mediated CACNA1S expression."
25915405
FERMT2 affects CACNA1S
| 1
CACNA1S binds FERMT2. 1 / 1
| 1
sparser
"We present genetic evidence that suggests cacn-1 interacts genetically with the Rac GTPase mig-2 to regulate distal tip cell pathfinding."
20188721
DMPK affects CACNA1S
| 1
DMPK phosphorylates CACNA1S. 1 / 1
| 1
rlimsp
"We observed that the beta subunit of DHPR was phosphorylated in vitro by Mt-PK."
7777513
CSNK2A1 affects CACNA1S
1 |
CSNK2A1 phosphorylates CACNA1S on T1579. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CAST affects CACNA1S
| 1
CAST activates CACNA1S. 1 / 1
| 1
reach
"Systemic administration of BDA-410, a specific calpain inhibitor, prevented TnT3 fragmentation, and Cacna1s and Cav1.1 downregulation and improved muscle force generation in sedentary old mice."
26892246
CAMK2A affects CACNA1S
1 |
CAMK2A phosphorylates CACNA1S on S1575. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CACNA1S affects ryanodine receptor
| 1 1
CACNA1S binds ryanodine receptor. 1 / 1
| 1 1
sparser
"In skeletal muscle, the CACNA1S containing VDCCs interact with ryanodine receptors."
27471951
CACNA1S affects release calcium
| 1
CACNA1S activates release calcium. 1 / 1
| 1
eidos
"ATP2A1 , RYR2 , RYR1 , CACNA1C , CACNA1D , and CACNA1S mediate the release of calcium , thereby playing a key role in triggering cardiac muscle contraction and maintaining the calcium homeostasis [ 56,57 ] ."
30231506
CACNA1S affects mertansine
| 1
CACNA1S activates mertansine. 1 / 1
| 1
reach
"In the case of Ca V 1.1 (CACNA1S) alternative splicing of exon 29 generates a calcium conducting Ca V 1.1 e that enhances calcium influx and generates spontaneous calcium sparklets in muscle fiber during EC coupling, resulting in reduced force and enhanced endurance as observed in myotonic dystrophies DM1 and DM2 [XREF_BIBR, XREF_BIBR]."
29510724
CACNA1S affects hypoPP
| 1
CACNA1S inhibits hypoPP. 1 / 1
| 1
reach
"Familial hypoPP is caused by loss-of-function mutations in at least two different genes : CACNL1A3 and SCN4A encoding for the alpha1 subunits of the skeletal muscle L-type Ca 2+ channel and voltage dependent Na + channels, respectively [15,16]."
17825556
CACNA1S affects hypoKPP
| 1
CACNA1S activates hypoKPP. 1 / 1
| 1
reach
"CACNA1S, SCN4A or KCNJ2 variants can cause hypoKPP."
31483760
CACNA1S affects firefly luciferase reporter gene
| 1
CACNA1S activates firefly luciferase reporter gene. 1 / 1
| 1
reach
"To examine the hypothesis that TnT3 regulates Cacna1s transcription, we performed a dual luciferase assay using a construct in which the Cacna1s promoter drives the firefly luciferase reporter gene (Zheng etal., 2002a)."
26892246
CACNA1S affects cell migration
| 1
CACNA1S activates cell migration. 1 / 1
| 1
reach
"To elucidate the mechanism by which CACN-1 mediates cell migration in C. elegans, we used tandem affinity purification and mass spectrometry to identify CACN-1-interacting molecules."
24948787
CACNA1S affects atp2b2
| 1
CACNA1S increases the amount of atp2b2. 1 / 1
| 1
reach
"The results showed that Se deficiency decreased the expression of SLC8A, CACNA1S, ORAI1, STIM1, SERCA, TRPC1, and TRPC3; increased the expression of PMCA; and did not influence RyR1 and RyR3 levels."
27557522
CACNA1S affects YWHAQ
1 |
YWHAQ binds CACNA1S. 1 / 1
1 |
biogrid
No evidence text available
20618440
CACNA1S affects Wnt
| 1
CACNA1S activates Wnt. 1 / 1
| 1
reach
"These findings suggest CACN-1 and Cactin modulates Wnt signaling during larval development."
24999833
CACNA1S affects Reactive Oxygen Species
| 1
CACNA1S increases the amount of Reactive Oxygen Species. 1 / 1
| 1
reach
"However, knockdown of CACNA1S reversed the effects of Rv2463 by increasing ROS levels (XREF_FIG), (compare grey line with dark line)."
25915405
CACNA1S affects RYR1, and STAC3
| 1
RYR1 binds CACNA1S and STAC3. 1 / 1
| 1
sparser
"Three genes, RYR1 , CACNA1S , and STAC3 , have been associated with MH susceptibility."
31016048
CACNA1S affects RIMS2
1 |
CACNA1S binds RIMS2. 1 / 1
1 |
hprd
No evidence text available
14660679
CACNA1S affects PPP2R2A
1 |
CACNA1S binds PPP2R2A. 1 / 1
1 |
biogrid
No evidence text available
22863883
CACNA1S affects PDZD3
1 |
CACNA1S binds PDZD3. 1 / 1
1 |
biogrid
No evidence text available
25416956
CACNA1S affects Neoplasm Invasiveness
| 1
CACNA1S activates Neoplasm Invasiveness. 1 / 1
| 1
reach
"Importantly, individual silencing of CACNA1D or CACNA1S gene expression using multiple siRNA oligos (XREF_SUPPLEMENTARY) decreased both filopodia formation and cancer cell invasion (XREF_FIG), indicating that CACNA1D and CACNA1S are likely to synergistically support filopodia formation and cancer cell invasion in MDA-MB-231 cells."
27910855
CACNA1S affects MSTN, RYR1, and STAC3
| 1
RYR1 binds CACNA1S, STAC3, and MSTN. 1 / 1
| 1
sparser
"Via DNA samples, genetic testing aims to find mutations in the genes responsible for contraction-excitation coupling and calcium regulation in skeletal muscle, namely RYR1 , CACNA1S , and STAC3 , that have been associated with MH [5] ."
27555149
CACNA1S affects MEGF10, and MMD
| 1
CACNA1S binds MEGF10 and MMD. 1 / 1
| 1
sparser
"Variations in MEGF10 and CACNA1S have also been associated with MmD [ xref , xref ]."
30406384
CACNA1S affects KCNQ1OT1
| 1
CACNA1S binds KCNQ1OT1. 1 / 1
| 1
sparser
"To further investigate a possible interaction between CACN-1 and LIT-1, we next determined the effect of cacn-1 RNAi on LIT-1 expression pattern and protein level."
24999833
CACNA1S affects IL2
| 1
CACNA1S activates IL2. 1 / 1
| 1
reach
"It was shown that reduced expression levels of CACNA1S leads to decreased production of Interleukin 2 (IL-2), less proliferation of CD4 + T cells, defective cytotoxic T lymphocyte (CTL) responses and therefore hampers Ca 2+ signaling [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
25915405
CACNA1S affects HypoKPP
| 1
CACNA1S-R1239H activates HypoKPP. 1 / 1
| 1
reach
"We have identified a large Beninese family in which HypoKPP segregated over five generations and was caused by the CACNA1S R1239H mutation."
17418573
CACNA1S affects HOPPK
| 1
CACNA1S activates HOPPK. 1 / 1
| 1
reach
"In this first reported case of unilateral adrenal hyperplasia in concurrence with hypokalaemic periodic paralysis, we identified a novel dominant mutation, p.Arg528Cys, of CACNA1S causing HOPPK, which is the third known pathogenic mutation involving the 528th code of CACNA1S."
25430699
CACNA1S affects HOKPP2
| 1
CACNA1S activates HOKPP2. 1 / 1
| 1
reach
"HOKPP1 and HOKPP2 are caused by mutations in CACNA1S (calcium channel, voltage dependent, L type, alpha 1S subunit) (OMIM # 114208) and SCN4A (sodium channel, voltage gated, type IV, alpha subunit) (OMIM # 603967), respectively [XREF_BIBR, XREF_BIBR]."
25430699
CACNA1S affects HOKPP1
| 1
CACNA1S activates HOKPP1. 1 / 1
| 1
reach
"HOKPP1 and HOKPP2 are caused by mutations in CACNA1S (calcium channel, voltage dependent, L type, alpha 1S subunit) (OMIM # 114208) and SCN4A (sodium channel, voltage gated, type IV, alpha subunit) (OMIM # 603967), respectively [XREF_BIBR, XREF_BIBR]."
25430699
CACNA1S affects FPP
| 1
CACNA1S activates FPP. 1 / 1
| 1
reach
"31 Although approximately 10% of FPP patients remain genetically undefined, mutations in the skeletal muscle Ca 2 + channel (CACNA1S) or Na + channel (SCN4A) genes are known to cause FPP."
21841462
CACNA1S affects DTC, and RAC
| 1
RAC binds CACNA1S and DTC. 1 / 1
| 1
sparser
"CACN-1 interacts genetically with the Rac GTPases to control DTC pathfinding."
20188721
CACNA1S affects CNBP
| 1
CACNA1S activates CNBP. 1 / 1
| 1
reach
"In the case of Ca V 1.1 (CACNA1S) alternative splicing of exon 29 generates a calcium conducting Ca V 1.1 e that enhances calcium influx and generates spontaneous calcium sparklets in muscle fiber during EC coupling, resulting in reduced force and enhanced endurance as observed in myotonic dystrophies DM1 and DM2 [XREF_BIBR, XREF_BIBR]."
29510724
CACNA1S affects Ala-Pro
| 1
CACNA1S activates Ala-Pro. 1 / 1
| 1
reach
"Causative mutations are located in the SCN4A gene encoding the sodium channel Nav1.4 initiating the AP, the CACNA1S gene encoding the calcium channel Cav1.1 coupling the AP to contraction, or the KCNJ2 and KCNJ18 genes encoding the potassium channels Kir2.1 and Kir2.6 that maintain the resting potential."
30838349
CACNA1S affects Actin
| 1
CACNA1S inhibits Actin. 1 / 1
| 1
reach
"In contrast, CACN-1 depleted animals had no actin sheath cell staining in 93% of gonad arms (n = 27) (XREF_FIG)."
27046631
CACNA1S affects ATP1A1
| 1
CACNA1S binds ATP1A1. 1 / 1
| 1
sparser
"HypoPP has been associated with mutations in both the α1-subunit of the skeletal muscle calcium channel, Cav1.1 (hypoPP type-1) and the α-subunit of the Nav1.4 channel (hypoPP type-2)."
21687503
CACNA1S affects AIR2
| 1
CACNA1S inhibits AIR2. 1 / 1
| 1
reach
"However, in the few escapers, CACN-1 depleted animals exhibited AIR-2 : : GFP fluorescence in 100% of the -1 and -2 oocytes and in 80% of the -3 oocytes (n = 6) (XREF_TABLE; XREF_FIG)."
27046631
CACN-1A affects CACNA1S
| 1
CACN-1A increases the amount of CACNA1S. 1 / 1
| 1
reach
"For TAP, mixed-stage C. elegans expressing hsp16.2 : : FLAG : : HA : : CACN-1A were incubated at 33degrees for 4 hr to induce strong expression of CACN-1 and subsequently harvested."
24948787
BIN1 affects CACNA1S, CLCN1, and PKM
| 1
BIN1 binds CACNA1S, CLCN1, and PKM. 1 / 1
| 1
sparser
"Among them, missplicing of CLCN1 , INR, PKM, CACNA1S and BIN1 pre-mRNAs have been associated with myotonia, insulin resistance, perturbed glucose metabolism and muscle weakness, respectively, all symptoms of DM1 (refs xref , xref , xref , xref , xref , xref )."
26018658
BDA-410 affects CACNA1S
| 1
BDA-410 inhibits CACNA1S. 1 / 1
| 1
reach
"Systemic administration of BDA-410, a specific calpain inhibitor, prevented TnT3 fragmentation, and Cacna1s and Cav1.1 downregulation and improved muscle force generation in sedentary old mice."
26892246
ATP1A1 affects CACNA1S
| 1
CACNA1S binds ATP1A1. 1 / 1
| 1
sparser
"HypoPP has been associated with mutations in both the α1-subunit of the skeletal muscle calcium channel, Cav1.1 (hypoPP type-1) and the α-subunit of the Nav1.4 channel (hypoPP type-2)."
21687503
ADRA1D affects CACNA1S, and DEGs
| 1
CACNA1S binds ADRA1D and DEGs. 1 / 1
| 1
sparser
"In the PPI network for ADRA1D , CACNA1S and the DEGs interacting with these components, PHB , OXTR , CRMP1 and DPYSL2 were revealed to have interaction relationships with both ADRA1D and CACNA1S ."
28413470
ABL1 affects CACNA1S, FERMT3, and ced-10
| 1
CACNA1S binds FERMT3, ABL1, and ced-10. 1 / 1
| 1
sparser
"The abl-1 /Abl kinase, which interacts with ABI-1, a cytoskeletal regulatory protein of the WASP-family verprolin-homologous (WAVE) protein complex, can suppress ced mutant phenotypes in the DTC. xref Mutations in the C. elegans homolog of the Drosophila Cactus binding protein Cactin/CACN-1 enhanced the ced-10 mutant phenotypes. xref Although the molecular mechanisms governing the interactions of CACN-1 or ABL-1 with CED-10 or MIG-2 have not been deciphered, the genetic data support potential roles for these molecules in modulating Rac signaling between adhesion and cytoskeletal dynamics."
23559979
CACNA1S affects calcium(2+), and calcium(2+)
|
CACNA1S catalyzes the conversion of calcium(2+) into calcium(2+). 1 / 1
1 |
biopax:panther
No evidence text available