INDRA statements for CACNA1I

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
CACNA1I affects calcium(2+)
| 4
CACNA1I activates calcium(2+).
| 2
CACNA1I activates calcium(2+). 2 / 2
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"A high affinity peptide blocker for these Ca channels is the scorpion toxin kurtoxin which inhibits the Ca (v) 3.1 and Ca (v) 3.2, but not the Ca (v) 3.3 channel in nanomolar concentrations."
15078185
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"There is evidence that a single copy of Chr22 :39665939 G> A CACNA1I triggers calcium channel disorder and is associated with the pathogenesis of SCZ [XREF_BIBR]."
28725167
CACNA1I inhibits calcium(2+).
| 1
CACNA1I inhibits calcium(2+). 1 / 1
| 1
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"A rare schizophrenia risk variant of CACNA1I disrupts Ca"
27756899
CACNA1I binds calcium(2+).
| 1
Calcium(2+) binds CACNA1I. 1 / 1
| 1
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"We describe here the identification of a new interaction between Ca (V) 3.3 and Ca (V) beta proteins."
20803093
Zinc(2+) affects CACNA1I
| 1
Zinc(2+) activates CACNA1I. 1 / 1
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"These data demonstrate that Zn (2+) modulates Ca (V) 3.3 channel gating thus leading to increased neuronal excitability."
17699699
Sodium atom affects CACNA1I
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Sodium atom activates CACNA1I. 1 / 1
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"With regards to voltage gated calcium (Ca 2+) channels (XREF_FIG), Na + deficiency significantly upregulated Cacna1i (Ca v 3.3; T-type), Cacna1e (Ca v 2.3; R-type), Cacna1c (Ca v 1.2; L-type) and Cacna1b (Ca v 2.2; N-type)."
28957668
Raloxifene affects CACNA1I
| 1
Raloxifene decreases the amount of CACNA1I. 1 / 1
| 1
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"We also found that raloxifene treatment decreased the mRNA expression of Ca (V) 3.2 and Ca (V) 3.3, but not Ca (V) 3.1 in GC-2spd (ts) cells (mouse spermatocyte cell line), as assessed by real-time RT-PCR."
21228613
Pyraclofos affects CACNA1I
| 1
Pyraclofos activates CACNA1I. 1 / 1
| 1
sparser
"The enriched expression of the voltage-activated calcium channel Cacna1i in the TRN long implicated these channels in the generation of characteristic TRN bursting ( xref ; xref )."
29673480
Hsa-miR-324-3p affects CACNA1I
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Transcriptionally active hsa-miR-324-3p decreases the amount of CACNA1I. 1 / 1
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biopax:mirtarbase
No evidence text available
23622248
Doxycycline affects CACNA1I
| 1
Doxycycline activates CACNA1I. 1 / 1
| 1
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"Threshold amplification cycle (CT) values were obtained for target (CACNA1I) and internal control (ACTB) to calculate incrementCT (CT target-CT reference), and DeltaDeltaCt calculated before and after induction of CACNA1I by doxycycline treatment."
27756899
Calcium(2+) affects CACNA1I
| 1
Calcium(2+) binds CACNA1I. 1 / 1
| 1
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"We describe here the identification of a new interaction between Ca (V) 3.3 and Ca (V) beta proteins."
20803093
N-(icosanoyl)ethanolamine affects CACNA1I
| 1
N-(icosanoyl)ethanolamine inhibits CACNA1I. 1 / 1
| 1
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"In contrast, lipids with a saturated alkyl chain, as N-arachidoyl glycine and N-arachidoyl ethanolamine, which did not inhibit the Ca (v) 3.3 current, had no effect on [(3) H] TTA-A1 binding."
24214826
N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoylethanolamine affects CACNA1I
| 1
N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoylethanolamine inhibits CACNA1I. 1 / 1
| 1
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"Using the whole-cell patch-clamp technique, we demonstrate that DHEA inhibits the three recombinant T-channels (Ca (V) 3.1, Ca (V) 3.2 and Ca (V) 3.3) expressed in NG108-15 cell line, as well as native T-channels in pulmonary artery smooth muscle cells."
22391268
Mibefradil affects CACNA1I
| 1
Mibefradil inhibits CACNA1I. 1 / 1
| 1
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"Mibefradil inhibits the expressed Ca (v2) 3.1, Ca (v) 3.2 and Ca (v) 3.3 channels in nanomolar concentrations with Ca (v) 3.3 channel having lowest affinity."
15078185
FADH2 affects CACNA1I
| 1
FADH2 activates CACNA1I. 1 / 1
| 1
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"38 An argument for urgency can also be made for the T-type calcium channel (CACNA1I), which is targeted by the FDA approved anticonvulsant zonisamide."
25869805
CALM affects CACNA1I
| 1
CALM binds CACNA1I. 1 / 1
| 1
sparser
"Yeast two-hybrid screening and co-immunoprecipitation revealed direct interaction of CaM with the carboxyl terminus of Cav3.3."
29452094
CACNA1I affects pyraclofos
| 1
CACNA1I increases the amount of pyraclofos. 1 / 1
| 1
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"We also provide evidence of altered mRNA expression of (1) voltage gated calcium channels P/Q-type Cacna1a (Cav 2.1), N-type Cacna1b (Cav 2.2), T-type Cav 3.1 Cacna1g, Cav 3.2 Cacna1h, Cav 3.3 Cacna1i and the auxiliary subunit Cacna2d1 (alpha2delta1); (2) hyperpolarization activated cyclic nucleotide gated channels Hcn1 and Hcn2; and (3) glutamate receptors subunits AMPA-type Gria1, NMDA-type Grin1 and metabotropic Grm1 in the mouse mPFC after repeated METH treatment."
25871318
CACNA1I affects REM1
| 1
CACNA1I activates REM1. 1 / 1
| 1
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"Antagonism of the Voltage Dependent T-Type Calcium Channel Alpha 1i Subunit (CACNA1I) Promotes Non REM Sleep."
22091728
CACNA1I affects HR
| 1
CACNA1I inhibits HR. 1 / 1
| 1
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"When ovarian cancer cases were considered, we observed an opposite trend for all CACNA loci compared to gastric and lung adenocarcinoma (XREF_SUPPLEMENTARY) : when all disease stages were analyzed, higher expression of CACNA-1G seemed to increase the risk of death (HR 1.22, 95% CI 1.07-1.40; p = 0.004), whereas higher expression of CACNA-1H and CACNA-1I reduced the risk (HR 0.82, 95% CI 0.71-0.96; p = 0.011 and HR 0.84, 0.73-0.97; p = 0.018, respectively)."
28846697
CACNA1I affects D15
| 1
CACNA1I activates D15. 1 / 1
| 1
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"Cacna1a, Cacna1g, Cacna1h, Cacna1i and Cacna2d1 mRNA expression behaved differently than Cacna1b since they were responsive to repeated METH induced D1/5 stimulation but were irresponsive to repeated SCH23390 alone treatment."
25871318
CACNA1I affects CALM
| 1
CALM binds CACNA1I. 1 / 1
| 1
sparser
"Yeast two-hybrid screening and co-immunoprecipitation revealed direct interaction of CaM with the carboxyl terminus of Cav3.3."
29452094
CACNA1I affects Ala-Pro
| 1
CACNA1I activates Ala-Pro. 1 / 1
| 1
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"Stable expression of Ca (v) 3.3 (T-type voltage gated calcium) channels in Ex-293 cells (to generate an ' ExCa-293 ' line) significantly increased their AP duration and reduced repolarization gradients in cocultures of these cells and NRVMs."
23104914
CACNA1I affects ALB
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CACNA1I binds ALB. 1 / 1
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biogrid
No evidence text available
15174051
ADRA1B affects AGA, AHSG, ALB, AMPD3, AP1M1, AP4E1, APOA1, APOA2, APOA4, APOC1, APOC2, APOC3, APOE, ATM, BBC3, CABLES1, CACNA1I, CAMTA1, CDC45, CDCP1, CEP44, CFB, CFD, CFH, CHKB, CLCA2, CNOT1, CRB1, CROT, CST3, CTSL, DCD, DDB1, DERL1, DGKG, DICER1, DMD, EXOC6, F2, F7, FAM71E2, FGA, FN1, GABBR1, GCN1, GFAP, GJC2, GRAP2, GSN, HP, HPX, IGDCC4, IGHG1, IGKC, ITGA2, ITGB5, ITIH1, JARID2, KCNMA1, KIAA0232, KLK3, KRT1, KRT10, KRT13, KRT14, KRT16, KRT5, KRT6A, KRT6B, KRT9, LAT, LDB3, MIA2, MYL4, MYLK3, NCOA3, NLRC4, NPHS1, OBSL1, OR2T6, OR3A2, OR8D2, PALB2, PCDH1, PCED1B, PDE4B, PDZRN4, PEG3, PF4V1, PHC3, PLA2G4F, PLAG1, PPBP, PRSS3, QTRT2, RANBP2, RANBP3, RESF1, RLF, RYR2, SACS, SCAF1, SCN5A, SERPING1, SETX, SGO2, SH3BP5, SLA2, SLC1A5, SLC25A13, SLC9A8, SORBS3, SPAST, SPATA31A7, ST13, THRAP3, TIAM1, TLN2, TRAPPC11, TSC22D1, TTN, TTPAL, TTR, ZNF232, and ZNF292
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