INDRA statements for CACNA1G

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
CACNA1G affects calcium(2+)
8 | 4
CACNA1G activates calcium(2+). 4 / 4
| 4
reach
"It is therefore tempting to speculate that enhanced expression of calcium channel subunits, especially Cacna1g which mediates a low-threshold calcium current, as well as other channels that flux calcium are required early in development when synaptic input is minimal, but that the need for these subunits is supplanted once synaptic inputs and firing patterns mature."
19474331
reach
"Specifically, adult ablation of P/Q channels does not promote Cacna1g mediated burst firing or T-type calcium current (IT) in the thalamocortical relay neurons; however, burst firing in thalamocortical relay neurons remains essential as iKOp/q mice generated on a Cacna1g deleted background show substantially diminished seizure generation."
31800012
reach
"However, nicotine showed bidirectional effects on the expression of genes involved in VDCC mediated calcium signaling and the Ca +2 / calmodulin dependent kinase signaling pathway, with 46%-57% upregulation of Camk4 and Cacnali expression in the hippocampus, 20%-25% upregulation of Calm1 and Camk2g expression in the amygdala, and 56%-73% downregulation of Camk2b, Camk4, Calm2, and Cacna1g expression in the PFC."
26205781
reach
"However, nicotine showed bidirectional effects on the expression of genes involved in VDCC mediated calcium signaling and the Ca +2 / calmodulin dependent kinase signaling pathway, with 46%-57% upregulation of Camk4 and Cacnali expression in the hippocampus, 20%-25% upregulation of Calm1 and Camk2g expression in the amygdala, and 56%-73% downregulation of Camk2b, Camk4, Calm2, and Cacna1g expression in the PFC."
26205781
NR2F2 affects CACNA1G
| 4 3
CACNA1C binds CACNA1G and NR2F2. 4 / 4
| 4
sparser
"Converging evidence from ENCODE ChIP-seq data and chromatin immunoprecipitation (ChIP)-qPCR results indicate that COUP-TFII interacts with CACNA1G and CACNA1C and not NKX2.5 ( xref C), implicating a role for COUP-TFII in the direct regulation of CACNA1G and CACNA1C gene expression and the functional changes observed in atrial-like hiPSC-CM calcium handling."
29731429
sparser
"Additionally, the genomic locations where COUP-TFII binds to CACNA1G and CACNA1C in human atrial cells and CMs are sensitive to DNase treatment, indicating that they are accessible for transcriptional regulation and are also highly conserved across species ( xref A and S2B)."
29731429
sparser
"COUP-TFII binding to the promoters of CACNA1G ( xref H) and CACNA1C ( xref I) was significantly increased in RA versus CT hiPSCs."
29731429
sparser
"Collectively, these data indicate that COUP-TFII may bind to CACNA1G and CACNA1C , thereby regulating their gene expression and modulating calcium handling in atrial-like hiPSC-CMs."
29731429
CACNA1G binds NR2F2. 3 / 3
| 3
reach
"Collectively, these data indicate that COUP-TFII may bind to CACNA1G and CACNA1C, thereby regulating their gene expression and modulating calcium handling in atrial like hiPSC-CMs."
29731429
reach
"Additionally, the genomic locations where COUP-TFII binds to CACNA1G and CACNA1C in human atrial cells and CMs are sensitive to DNase treatment, indicating that they are accessible for transcriptional regulation and are also highly conserved across species (XREF_SUPPLEMENTARY A and S2B)."
29731429
reach
"Converging evidence from ENCODE ChIP-seq data and chromatin immunoprecipitation (ChIP)-qPCR results indicate that COUP-TFII interacts with CACNA1G and CACNA1C and not NKX2.5 (XREF_SUPPLEMENTARY C), implicating a role for COUP-TFII in the direct regulation of CACNA1G and CACNA1C gene expression and the functional changes observed in atrial like hiPSC-CM calcium handling."
29731429
CALM affects CACNA1G
| 7
CALM binds CACNA1G. 6 / 6
| 6
sparser
"The precise amino acid residues on the C-terminus responsible for the Cav3.1-CaM interaction remain to be determined."
28800734
sparser
"We tested the potential for Cav3.1 and CaM to physically associate using coimmunoprecipitation, first performed in the presence of a buffered calcium concentration of 100 nM to simulate resting conditions of intracellular calcium (see xref )."
28800734
sparser
"These findings are important in revealing a dynamic interaction between Cav3.1 and CaM that is essentially opposite to that of HVA calcium channels."
28800734
sparser
"We now report that under resting conditions, CaM constitutively associates with the C-terminus of Cav3.1, as revealed in both a heterologous expression system and rodent brain."
28800734
sparser
"Dynamics of Cav3.1 and CaM interactions revealed by FRET."
28800734
sparser
"Our findings thus establish that T-type channel calcium influx invokes a novel dynamic interaction between CaM and Cav3.1 channels to trigger a signaling cascade that leads to αCaMKII activation."
28800734
CALM binds CACNA1G and αCaMKII. 1 / 1
| 1
sparser
"Thus, the sequence of events identified for Cav3.1-CaM-αCaMKII interactions differs from that of HVA calcium channels, revealing separate pathways to activate αCaMKII."
28800734
CACNA1G affects NR2F2
| 4 3
CACNA1C binds CACNA1G and NR2F2. 4 / 4
| 4
sparser
"Converging evidence from ENCODE ChIP-seq data and chromatin immunoprecipitation (ChIP)-qPCR results indicate that COUP-TFII interacts with CACNA1G and CACNA1C and not NKX2.5 ( xref C), implicating a role for COUP-TFII in the direct regulation of CACNA1G and CACNA1C gene expression and the functional changes observed in atrial-like hiPSC-CM calcium handling."
29731429
sparser
"Additionally, the genomic locations where COUP-TFII binds to CACNA1G and CACNA1C in human atrial cells and CMs are sensitive to DNase treatment, indicating that they are accessible for transcriptional regulation and are also highly conserved across species ( xref A and S2B)."
29731429
sparser
"COUP-TFII binding to the promoters of CACNA1G ( xref H) and CACNA1C ( xref I) was significantly increased in RA versus CT hiPSCs."
29731429
sparser
"Collectively, these data indicate that COUP-TFII may bind to CACNA1G and CACNA1C , thereby regulating their gene expression and modulating calcium handling in atrial-like hiPSC-CMs."
29731429
CACNA1G binds NR2F2. 3 / 3
| 3
reach
"Collectively, these data indicate that COUP-TFII may bind to CACNA1G and CACNA1C, thereby regulating their gene expression and modulating calcium handling in atrial like hiPSC-CMs."
29731429
reach
"Additionally, the genomic locations where COUP-TFII binds to CACNA1G and CACNA1C in human atrial cells and CMs are sensitive to DNase treatment, indicating that they are accessible for transcriptional regulation and are also highly conserved across species (XREF_SUPPLEMENTARY A and S2B)."
29731429
reach
"Converging evidence from ENCODE ChIP-seq data and chromatin immunoprecipitation (ChIP)-qPCR results indicate that COUP-TFII interacts with CACNA1G and CACNA1C and not NKX2.5 (XREF_SUPPLEMENTARY C), implicating a role for COUP-TFII in the direct regulation of CACNA1G and CACNA1C gene expression and the functional changes observed in atrial like hiPSC-CM calcium handling."
29731429
CACNA1G affects CALM
| 7
CALM binds CACNA1G. 6 / 6
| 6
sparser
"The precise amino acid residues on the C-terminus responsible for the Cav3.1-CaM interaction remain to be determined."
28800734
sparser
"We tested the potential for Cav3.1 and CaM to physically associate using coimmunoprecipitation, first performed in the presence of a buffered calcium concentration of 100 nM to simulate resting conditions of intracellular calcium (see xref )."
28800734
sparser
"These findings are important in revealing a dynamic interaction between Cav3.1 and CaM that is essentially opposite to that of HVA calcium channels."
28800734
sparser
"We now report that under resting conditions, CaM constitutively associates with the C-terminus of Cav3.1, as revealed in both a heterologous expression system and rodent brain."
28800734
sparser
"Dynamics of Cav3.1 and CaM interactions revealed by FRET."
28800734
sparser
"Our findings thus establish that T-type channel calcium influx invokes a novel dynamic interaction between CaM and Cav3.1 channels to trigger a signaling cascade that leads to αCaMKII activation."
28800734
CALM binds CACNA1G and αCaMKII. 1 / 1
| 1
sparser
"Thus, the sequence of events identified for Cav3.1-CaM-αCaMKII interactions differs from that of HVA calcium channels, revealing separate pathways to activate αCaMKII."
28800734
LEF1 affects CACNA1G
1 | 1 2
LEF1 activates CACNA1G.
| 1 2
LEF1 activates CACNA1G. 3 / 3
| 1 2
reach
"To determine whether the beta, catenin, LEF1, and TCF complex might directly regulate Cacna1g, Cacna2d2, Kcna6, Kcnh8, Drd3, Gabra3, Glra1, Grid2, and Calb2, we analyzed the in vivo binding of beta-catenin to LEF1 and TCF motifs within the CNSs using a chromatin immunoprecipitation (ChIP) assay with designed primers."
23157480
sparser
"Luciferase reporter assays confirmed that the Cacna1G promoter is activated by LEF1 and beta-catenin, and footprinting analysis revealed four LEF1 binding sites in the proximal region of this promoter."
20371816
reach
"Luciferase reporter assays confirmed that the Cacna1G promoter is activated by LEF1 and beta-catenin, and footprinting analysis revealed four LEF1 binding sites in the proximal region of this promoter."
20371816
LEF1 increases the amount of CACNA1G.
1 |
Transcriptionally active LEF1 increases the amount of CACNA1G. 1 / 1
1 |
biopax:pid
No evidence text available
20371816
E2 affects CACNA1G
| 4
E2 increases the amount of CACNA1G.
| 3
E2 increases the amount of CACNA1G. 3 / 3
| 3
reach
"E2 replacement significantly suppressed the mRNA expression of Adra1b, Cart, Chrm1, Esr1, Kiss1, Pdyn, NKB (Tac2), and Tac3r and significantly augmented expression of Cacna1g, Esr2, Ghsr, Kcnmb1, Kiss1r, and Pgr."
26768413
reach
"In the current study, E2 (or treatment with E2B) increased channel expression of Cacna1g and Kcnmb1 in WT females only, a finding supported by previous studies, but not in KIKO or ERKO [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
26768413
reach
"Presently, we show that E2 augmented the excitability of Kiss1 ARH neurons by amplifying Cacna1g, Hcn1 and Hcn2 mRNA expression and T-type calcium and h-currents."
30079889
E2 decreases the amount of CACNA1G.
| 1
E2 decreases the amount of CACNA1G. 1 / 1
| 1
reach
"E2 replacement significantly suppressed the mRNA expression of Adra1b, Cart, Chrm1, Esr1, Kiss1, Pdyn, NKB (Tac2), and Tac3r and significantly augmented expression of Cacna1g, Esr2, Ghsr, Kcnmb1, Kiss1r, and Pgr."
26768413
CACNA1C affects CACNA1G, and NR2F2
| 4
CACNA1C binds CACNA1G and NR2F2. 4 / 4
| 4
sparser
"Converging evidence from ENCODE ChIP-seq data and chromatin immunoprecipitation (ChIP)-qPCR results indicate that COUP-TFII interacts with CACNA1G and CACNA1C and not NKX2.5 ( xref C), implicating a role for COUP-TFII in the direct regulation of CACNA1G and CACNA1C gene expression and the functional changes observed in atrial-like hiPSC-CM calcium handling."
29731429
sparser
"Additionally, the genomic locations where COUP-TFII binds to CACNA1G and CACNA1C in human atrial cells and CMs are sensitive to DNase treatment, indicating that they are accessible for transcriptional regulation and are also highly conserved across species ( xref A and S2B)."
29731429
sparser
"COUP-TFII binding to the promoters of CACNA1G ( xref H) and CACNA1C ( xref I) was significantly increased in RA versus CT hiPSCs."
29731429
sparser
"Collectively, these data indicate that COUP-TFII may bind to CACNA1G and CACNA1C , thereby regulating their gene expression and modulating calcium handling in atrial-like hiPSC-CMs."
29731429
CTNNB1 affects CACNA1G
1 | 1 1
CTNNB1 activates CACNA1G.
| 1 1
CTNNB1 activates CACNA1G. 2 / 2
| 1 1
reach
"Luciferase reporter assays confirmed that the Cacna1G promoter is activated by LEF1 and beta-catenin, and footprinting analysis revealed four LEF1 binding sites in the proximal region of this promoter."
20371816
sparser
"Luciferase reporter assays confirmed that the Cacna1G promoter is activated by LEF1 and beta-catenin, and footprinting analysis revealed four LEF1 binding sites in the proximal region of this promoter."
20371816
CTNNB1 increases the amount of CACNA1G.
1 |
Transcriptionally active CTNNB1 increases the amount of CACNA1G. 1 / 1
1 |
biopax:pid
No evidence text available
20371816
CACNA1G affects AS1
| 3
CACNA1G binds AS1. 3 / 3
| 3
sparser
"Through Western blot, RNA immunoprecipitation (RIP), and chromatin immunoprecipitation (ChIP) assay, the interaction between CACNA1G-AS1 and EZH2 was assessed."
31957825
sparser
"For example, the lncRNA CACNA1G-AS1 facilitates hepatocellular carcinoma progression via the miR-2392/C1orf61 pathway[ xref ]."
32351291
sparser
"For example, the lncRNA CACNA1G-AS1 facilitates hepatocellular carcinoma progression via the miR-2392/C1orf61 pathway[ xref ]."
32351291
UBQLN4 affects CACNA1G
1 1 |
UBQLN4 binds CACNA1G. 2 / 2
1 1 |
hprd
No evidence text available
16713569
biogrid
No evidence text available
16713569
PKA affects CACNA1G
| 2
PKA phosphorylates CACNA1G. 2 / 2
| 2
sparser
"PKA might phosphorylate Cav3.1 directly as it does on L-type (Cav1) Ca 2+ channels."
22808078
sparser
"It is possible that PKA-dependent phosphorylation of Cav3.1 augments the open probability of the channel, as it does to the L-type Ca 2+ channel."
22808078
NR3C1 affects CACNA1G
| 1 1
CACNA1G binds NR3C1. 1 / 1
| 1
reach
"While there is still insufficient evidence to infer the existence of a direct interaction between CREB and the GR binding cacna1g promoter, it seems likely that the I CaT -induced decrease in cacna1g expression is due to a defect in CREB interference with the GR binding activity of GRE1."
21123217
CREB binds CACNA1G and NR3C1. 1 / 1
| 1
sparser
"While there is still insufficient evidence to infer the existence of a direct interaction between CREB and the GR-binding cacna1g promoter, it seems likely that the I CaT -induced decrease in cacna1g expression is due to a defect in CREB interference with the GR-binding activity of GRE1."
21123217
CACNA1G affects αCaMKII
| 2
CACNA1G binds αCaMKII.
| 1
CALM binds CACNA1G and αCaMKII. 1 / 1
| 1
sparser
"Thus, the sequence of events identified for Cav3.1-CaM-αCaMKII interactions differs from that of HVA calcium channels, revealing separate pathways to activate αCaMKII."
28800734
CACNA1G activates αCaMKII.
| 1
CACNA1G activates αCaMKII. 1 / 1
| 1
sparser
"Cav3.1 calcium activation of αCaMKII depends on an intact Cav3.1 C-terminus."
28800734
CACNA1G affects gamma-aminobutyric acid
| 2
CACNA1G activates gamma-aminobutyric acid. 2 / 2
| 2
reach
"In mice, targeted deletion of Cacna1g diminishes GABA B -receptor agonist induced spike-wave discharges (SWDs), while overexpression of Cacna1g is associated with absence seizures and abnormal thalamocortical synchronization."
27112236
reach
"Deletion of Cacna1g in mice suppressed GABA B receptor agonist induced SWDs, indicating an essential role for this gene in seizure expression."
22471526
CACNA1G affects cell population proliferation
| 1 2
CACNA1G inhibits cell population proliferation. 2 / 2
| 1 2
reach
"Notably, CACNA1G gene knock-down and the Ca V 3 channel blocker, mibefradil, significantly reduced the rate of cell proliferation in this cancer [XREF_BIBR]."
26010603
reach
"In human glioblastoma cells, mibefradil, a T-type Ca 2+ channel blocker with a weak L-type channel inhibiting activity [XREF_BIBR], and siRNA mediated downregulation of CACNA1G (Ca V.3.1) and CACNA1H (Ca V 3.2) reduces cell proliferation, induces apoptotic cell death, and sensitizes cells to ionizing radiation via AKT and mTORC2 axis [XREF_BIBR]."
30691160
CACNA1G affects UBQLN4
1 1 |
UBQLN4 binds CACNA1G. 2 / 2
1 1 |
hprd
No evidence text available
16713569
biogrid
No evidence text available
16713569
CACNA1G affects NR3C1
| 1 1
CACNA1G binds NR3C1. 1 / 1
| 1
reach
"While there is still insufficient evidence to infer the existence of a direct interaction between CREB and the GR binding cacna1g promoter, it seems likely that the I CaT -induced decrease in cacna1g expression is due to a defect in CREB interference with the GR binding activity of GRE1."
21123217
CREB binds CACNA1G and NR3C1. 1 / 1
| 1
sparser
"While there is still insufficient evidence to infer the existence of a direct interaction between CREB and the GR-binding cacna1g promoter, it seems likely that the I CaT -induced decrease in cacna1g expression is due to a defect in CREB interference with the GR-binding activity of GRE1."
21123217
17beta-estradiol affects CACNA1G
| 2
17beta-estradiol inhibits CACNA1G. 2 / 2
| 2
reach
"The Bonferroni post-hoc analysis indicated that 100 and 1000 nM beta-estradiol significantly downregulated CACNA1G by 0.77-fold (p < 0.01) and 0.74-fold (p < 0.05), CACNA1GH by 0.73-fold (p < 0.05) and 0.82-fold (p < 0.05), CACNA1GH by 0.68-fold (p < 0.05) and 0.89-fold (p < 0.01), CACNA1GC by 0.49-fold (p < 0.01) and 0.36-fold (p < 0.01), respectively, versus the non treated samples."
29747396
reach
"The Bonferroni post-hoc analysis indicated that 100 nM beta-estradiol significantly downregulated CACNA1G by 0.67-fold (p < 0.05), CACNA1GH by 0.75-fold (p < 0.05), CACNA1GH by 0.86-fold (p < 0.05), versus non treated samples."
29747396
Toxin affects CACNA1G
| 1
Toxin inhibits CACNA1G. 1 / 1
| 1
sparser
"Additionally, we have found that lipid partitioning strength is a potential predictor for how well a toxin inhibits Cav3.1 channels."
27045173
MiR-204 affects CACNA1G
| 1
MiR-204 increases the amount of CACNA1G. 1 / 1
| 1
reach
"Our results show that miR-204 promotes the increased expression of both CACNA1G and CACNA1H mRNA, and, in this way, upregulates T-type Ca 2+ currents."
30262720
Hsa-miR-6883-3p affects CACNA1G
1 |
Transcriptionally active hsa-miR-6883-3p decreases the amount of CACNA1G. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-5006-3p affects CACNA1G
1 |
Transcriptionally active hsa-miR-5006-3p decreases the amount of CACNA1G. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4755-5p affects CACNA1G
1 |
Transcriptionally active hsa-miR-4755-5p decreases the amount of CACNA1G. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4446-5p affects CACNA1G
1 |
Transcriptionally active hsa-miR-4446-5p decreases the amount of CACNA1G. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3162-3p affects CACNA1G
1 |
Transcriptionally active hsa-miR-3162-3p decreases the amount of CACNA1G. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Catenin affects CACNA1G
| 1
Catenin activates CACNA1G. 1 / 1
| 1
reach
"To determine whether the beta, catenin, LEF1, and TCF complex might directly regulate Cacna1g, Cacna2d2, Kcna6, Kcnh8, Drd3, Gabra3, Glra1, Grid2, and Calb2, we analyzed the in vivo binding of beta-catenin to LEF1 and TCF motifs within the CNSs using a chromatin immunoprecipitation (ChIP) assay with designed primers."
23157480
Arachidonic acid affects CACNA1G
| 1
Arachidonic acid inhibits CACNA1G. 1 / 1
| 1
sparser
"A Hill coefficient of 1.6 best describes inhibition of Cav3.1 by AA suggesting that at least two AA molecules cooperatively interact with one channel [ xref , xref , xref ]."
19419761
Alpha1G-Tg2 affects CACNA1G
| 1
Alpha1G-Tg2 increases the amount of CACNA1G. 1 / 1
| 1
reach
"Myocardial Cacna1g mRNA levels were increased by 47% and 27% in the alpha1G-Tg1 and alpha1G-Tg2 lines, respectively."
19211869
Alpha1G-Tg1 affects CACNA1G
| 1
Alpha1G-Tg1 increases the amount of CACNA1G. 1 / 1
| 1
reach
"Myocardial Cacna1g mRNA levels were increased by 47% and 27% in the alpha1G-Tg1 and alpha1G-Tg2 lines, respectively."
19211869
Aldosterone affects CACNA1G
| 1
Aldosterone activates CACNA1G. 1 / 1
| 1
reach
"Mutations of GRE1 abolish CACNA1G transcriptional activation induced by aldosterone stimulation [XREF_BIBR]."
30262720
TCF_LEF affects CACNA1G
| 1
TCF_LEF activates CACNA1G. 1 / 1
| 1
reach
"To determine whether the beta, catenin, LEF1, and TCF complex might directly regulate Cacna1g, Cacna2d2, Kcna6, Kcnh8, Drd3, Gabra3, Glra1, Grid2, and Calb2, we analyzed the in vivo binding of beta-catenin to LEF1 and TCF motifs within the CNSs using a chromatin immunoprecipitation (ChIP) assay with designed primers."
23157480
TBX3 affects CACNA1G
| 1
TBX3 binds CACNA1G. 1 / 1
| 1
sparser
"CACNA1G ( xref ) and TBX3 ( xref ) were associated with progression and SFRP5 correlated with recurrence ( xref )."
31850055
RYR affects CACNA1G
| 1
CACNA1G binds RYR. 1 / 1
| 1
sparser
"Application of ryanodine did not affect the calcium current through T type calcium channels and we concluded that RyRs and T type VGCCs do not interact with each other ( xref )."
23826376
RANBP9 affects CACNA1G
1 |
RANBP9 binds CACNA1G. 1 / 1
1 |
biogrid
No evidence text available
18801335
P/Q channels affects CACNA1G
| 1
P/Q channels activates CACNA1G. 1 / 1
| 1
reach
"Specifically, adult ablation of P/Q channels does not promote Cacna1g mediated burst firing or T-type calcium current (IT) in the thalamocortical relay neurons; however, burst firing in thalamocortical relay neurons remains essential as iKOp/q mice generated on a Cacna1g deleted background show substantially diminished seizure generation."
31800012
NOG affects CACNA1G
1 |
Transcriptionally active NOG increases the amount of CACNA1G. 1 / 1
1 |
biopax:ctd
No evidence text available
27188386
GRE1 affects CACNA1G
| 1
Mutated GRE1 inhibits CACNA1G. 1 / 1
| 1
reach
"Mutations of GRE1 abolish CACNA1G transcriptional activation induced by aldosterone stimulation [XREF_BIBR]."
30262720
CXXC1 affects CACNA1G
| 1
CXXC1 methylates CACNA1G. 1 / 1
| 1
sparser
"In addition to MSI, CpG island methylation in MLH1 , IGF2 , and CACNA1G genes were highly connected to other biomarkers mainly in proximal colon cancer."
28623901
CAS1 knockdown affects CACNA1G
| 1
CAS1 knockdown increases the amount of CACNA1G. 1 / 1
| 1
reach
"The finding that CACNA1G expression was downregulated by CAS1 knockdown suggests that CAS1 affects calcium channel expression, leading to a reduction in collagen levels and cell invasion."
29963160
CAS1 affects CACNA1G
| 1
CAS1 increases the amount of CACNA1G. 1 / 1
| 1
reach
"In conclusion, CAS1 may promote the expression of the calcium channel protein CACNA1G and type I collagen, and also have a positive effect on cell migration in human keloid fibroblasts, rendering it a potential new therapeutic target for keloids."
29963160
CACNA1G affects sensor
| 1
CACNA1G activates sensor. 1 / 1
| 1
reach
"In CACNA1G, we identified a c. 5144G> A mutation, causing an arginine-to-histidine (p.Arg1715His) change in the voltage sensor S4 segment of the T-type channel protein Cav3.1."
26456284
CACNA1G affects pyraclofos
| 1
CACNA1G activates pyraclofos. 1 / 1
| 1
reach
"In CACNA1G, we identified a c. 5144G> A mutation, causing an arginine-to-histidine (p.Arg1715His) change in the voltage sensor S4 segment of the T-type channel protein Cav3.1."
26456284
CACNA1G affects cell growth
| 1
CACNA1G activates cell growth. 1 / 1
| 1
reach
"The knockdown of a single T-type Ca (2+) channel subunit (CACNA1G) reduced cell growth and induced caspase-3/7 activation in HCT116 p53wt cells as compared with HCT116 mutant p53 (-/-) cells."
24362252
CACNA1G affects cell death
| 1
CACNA1G activates cell death. 1 / 1
| 1
reach
"When ovarian cancer cases were considered, we observed an opposite trend for all CACNA loci compared to gastric and lung adenocarcinoma (XREF_SUPPLEMENTARY) : when all disease stages were analyzed, higher expression of CACNA-1G seemed to increase the risk of death (HR 1.22, 95% CI 1.07-1.40; p = 0.004), whereas higher expression of CACNA-1H and CACNA-1I reduced the risk (HR 0.82, 95% CI 0.71-0.96; p = 0.011 and HR 0.84, 0.73-0.97; p = 0.018, respectively)."
28846697
CACNA1G affects ataxia [
| 1
CACNA1G activates ataxia [. 1 / 1
| 1
reach
"Calcium voltage gated channel subunit alpha 1 G (CACNA1G) mutation leads to altered physiological property in the low voltage gated calcium channel and causes a relatively pure cerebellar ataxia [XREF_BIBR, XREF_BIBR]."
30284037
CACNA1G affects alpha1 subunit
| 1
CACNA1G activates alpha1 subunit. 1 / 1
| 1
reach
"The CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E and CACNA1G genes produce various isoform of alpha1 subunit including A, B, C, D, E and G, respectively."
24768178
CACNA1G affects adult-onset spinocerebellar ataxia 42
| 1
CACNA1G activates adult-onset spinocerebellar ataxia 42. 1 / 1
| 1
reach
"Although a recurrent heterozygous mutation (p.Arg1715His) in CACNA1G is known to cause adult-onset spinocerebellar ataxia 42 (SCA42 * 616795), gain-of-function mutations in this gene have recently been identified by whole exome sequencing (WES) in four children with cerebellar atrophy and ataxia, psychomotor delay, and other variable features."
31836334
CACNA1G affects TBX3
| 1
TBX3 binds CACNA1G. 1 / 1
| 1
sparser
"CACNA1G ( xref ) and TBX3 ( xref ) were associated with progression and SFRP5 correlated with recurrence ( xref )."
31850055
CACNA1G affects SCA
| 1
CACNA1G activates SCA. 1 / 1
| 1
reach
"Our study revealed that a mutation in CACNA1G encoding the T-type calcium channel Ca V 3.1 causes SCA."
26715324
CACNA1G affects RYR2, and VEGFA
| 1
RYR2 binds VEGFA and CACNA1G. 1 / 1
| 1
sparser
"Ryr2 and Cacna1g were strongly positively associated to VegfA , with the r values of 0.814, and 0.730, respectively; while both are negatively associated to that of VegfB , with correlation r values of −0.463 and −0.436."
29944851
CACNA1G affects RYR
| 1
CACNA1G binds RYR. 1 / 1
| 1
sparser
"Application of ryanodine did not affect the calcium current through T type calcium channels and we concluded that RyRs and T type VGCCs do not interact with each other ( xref )."
23826376
CACNA1G affects RANBP9
1 |
RANBP9 binds CACNA1G. 1 / 1
1 |
biogrid
No evidence text available
18801335
CACNA1G affects Leu-Val
| 1
CACNA1G activates Leu-Val. 1 / 1
| 1
reach
"CACNA1G deletion results in increased fibrosis and decreased LV function after TAC [XREF_BIBR]."
26001054
CACNA1G affects IGF2, MLH1, NEUROG1, RUNX3, SPEN, and WRN
| 1
RUNX3 binds WRN, CACNA1G, SPEN, IGF2, MLH1, and NEUROG1. 1 / 1
| 1
sparser
"Overall CIMP-high status (either >or=9/13 or >or=7/13 methylated markers; identifying 3 or 5 CIMP-high tumors, respectively) and methylation in CACNA1G, IGF2, MLH1, NEUROG1, RUNX3, MINT31, and WRN were associated with worse survival (all p < 0.01)."
17372756
CACNA1G affects HR
| 1
CACNA1G activates HR. 1 / 1
| 1
reach
"When ovarian cancer cases were considered, we observed an opposite trend for all CACNA loci compared to gastric and lung adenocarcinoma (XREF_SUPPLEMENTARY) : when all disease stages were analyzed, higher expression of CACNA-1G seemed to increase the risk of death (HR 1.22, 95% CI 1.07-1.40; p = 0.004), whereas higher expression of CACNA-1H and CACNA-1I reduced the risk (HR 0.82, 95% CI 0.71-0.96; p = 0.011 and HR 0.84, 0.73-0.97; p = 0.018, respectively)."
28846697
CACNA1G affects D15
| 1
CACNA1G activates D15. 1 / 1
| 1
reach
"Cacna1a, Cacna1g, Cacna1h, Cacna1i and Cacna2d1 mRNA expression behaved differently than Cacna1b since they were responsive to repeated METH induced D1/5 stimulation but were irresponsive to repeated SCH23390 alone treatment."
25871318
CACNA1G affects Caspase_3_7
| 1
CACNA1G inhibits Caspase_3_7. 1 / 1
| 1
reach
"The knockdown of a single T-type Ca (2+) channel subunit (CACNA1G) reduced cell growth and induced caspase-3/7 activation in HCT116 p53wt cells as compared with HCT116 mutant p53 (-/-) cells."
24362252
CACNA1G affects CREB, and NR3C1
| 1
CREB binds CACNA1G and NR3C1. 1 / 1
| 1
sparser
"While there is still insufficient evidence to infer the existence of a direct interaction between CREB and the GR-binding cacna1g promoter, it seems likely that the I CaT -induced decrease in cacna1g expression is due to a defect in CREB interference with the GR-binding activity of GRE1."
21123217
CACNA1G affects CDKN2A, IGF2, MLH1, NEUROG1, RUNX3, SIRT1, and SOCS1
| 1
RUNX3 binds CACNA1G, SIRT1, CDKN2A, SOCS1, IGF2, MLH1, and NEUROG1. 1 / 1
| 1
sparser
"SIRT1 expression was significantly associated with hypermethylation at CACNA1G, IGF2, MLH1, NEUROG1, RUNX3, SOCS1 , MINT31 and p14 ( xref )."
19430421
CACNA1G affects CALM, and αCaMKII
| 1
CALM binds CACNA1G and αCaMKII. 1 / 1
| 1
sparser
"Thus, the sequence of events identified for Cav3.1-CaM-αCaMKII interactions differs from that of HVA calcium channels, revealing separate pathways to activate αCaMKII."
28800734
CACNA1G affects CACNA1H, and spectrin family
| 1
CACNA1G binds CACNA1H and spectrin family. 1 / 1
| 1
sparser
"The data indicate that the proximal carboxy-terminus regions of Cav3.1 and Cav3.2 binds to spectrins (α/β) via a 24 amino acid stretch containing many negatively charged residues located in close proximity to the transmembrane domain of these channels."
29720258
CACNA1G affects ANK1
| 1
CACNA1G binds ANK1. 1 / 1
| 1
sparser
"Deletion of the proximal C-terminal alpha helix in the two channels reduced ankyrin B interactions with Cav3.1 and to a lesser extent with Cav3.2 (Fig.  xref and xref )."
29720258
APP affects CACNA1G
1 |
Transcriptionally active APP increases the amount of CACNA1G. 1 / 1
1 |
biopax:ctd
No evidence text available
21298039
ANK1 affects CACNA1G
| 1
CACNA1G binds ANK1. 1 / 1
| 1
sparser
"Deletion of the proximal C-terminal alpha helix in the two channels reduced ankyrin B interactions with Cav3.1 and to a lesser extent with Cav3.2 (Fig.  xref and xref )."
29720258
CACNA1G affects calcium(2+), and calcium(2+)
|
CACNA1G catalyzes the conversion of calcium(2+) into calcium(2+). 4 / 4
4 |
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available