"Future studies will determine if the CACNA1E SNP rs679931 (TT) modulates the expression or function of human Ca V 2.3, which glucose sensitive cells CaV2.3 influences and how this modulates human glucose homeostasis."
"In addition, the drastically suppressed LC3A and B-II levels in Hep3B cells treated with rTF, rFVII or PAR2 agonist were rescued by mTOR siRNA transfection (XREF_FIG)."
"The LC3A and B-II expression levels, which drastically inhibited by rTF, rFVII or PAR2 activation, were fully rescued by mTOR knockdown in vitro, suggesting mTOR signaling pathway could have a key role in tumor malignancy through TF/FVII/PAR2 mediated suppression of autophagy."
"We conclude that genetic variation in the CACNA1E gene contributes to an increased risk of the development of type 2 diabetes by reducing insulin secretion."
"In addition, upregulated miRNAs inhibited insulin secretion via calcium voltage gated channel subunit alpha1 E (CACNA1E), a voltage dependent R type calcium channel."
"The LC3A and B-II expression levels, which drastically inhibited by rTF, rFVII or PAR2 activation, were fully rescued by mTOR knockdown in vitro, suggesting mTOR signaling pathway could have a key role in tumor malignancy through TF/FVII/PAR2 mediated suppression of autophagy."
"The LC3A and B-II expression levels, which drastically inhibited by rTF, rFVII or PAR2 activation, were fully rescued by mTOR knockdown in vitro, suggesting mTOR signaling pathway could have a key role in tumor malignancy through TF/FVII/PAR2 mediated suppression of autophagy."
"XREF_BIBR, XREF_BIBR, XREF_BIBR We found that tenovin-6 treatment significantly increased LC3A and B-II in wild-type but not ATG5 -/- and ATG7 -/- MEF cells (XREF_FIG)."
"With regards to voltage gated calcium (Ca 2+) channels (XREF_FIG), Na + deficiency significantly upregulated Cacna1i (Ca v 3.3; T-type), Cacna1e (Ca v 2.3; R-type), Cacna1c (Ca v 1.2; L-type) and Cacna1b (Ca v 2.2; N-type)."
"We further found that the LC3A and B-II expression was induced by sirolimus, a main selective inhibitor of mTOR, and the sirolimus induced LC3A and B-II was partially reduced by rTF exposure, but was fully suppressed in the presence of rFVII or PAR2 agonist (see XREF_SUPPLEMENTARY)."
"These findings strongly suggest that both H179 and H183 in the IS3-IS4 loop are essential structural determinants required for nickel sensitive inhibition of the Cav2.3."
"suggested that curcumin or solid lipid curcumin particles treatment could increase the levels of LC3A and B-II and Beclin-1, indicating that maintenance or restoration of heat shock proteins and regulation of autophagy-lysosomal pathways by curcumin may provide a promising strategy to degrade Abeta-aggregates from neurons in the AD brain."
"As shown in XREF_FIG, B and C, VPS13C was barely detected in islets isolated from betaVps13cKO mice (XREF_FIG and Ci) and levels of Vps13c mRNA were significantly reduced (XREF_FIG, Bii and Cii) by> 80%."
"However, expression of TRPM3WT but not TRPM3DN in HEK293 cells induced accumulation of LC3A and B-II (XREF_SUPPLEMENTARY), suggesting that increased expression of TRPM3 may force a connection with the autophagic pathway."
"However, expression of TRPM3WT but not TRPM3DN in HEK293 cells induced accumulation of LC3A and B-II (XREF_SUPPLEMENTARY), suggesting that increased expression of TRPM3 may force a connection with the autophagic pathway."
"The effect of Vc1.1 on Cav2.3 channels was completely VI and depended on the presence of specific c-Src phosphorylation sites in the C terminus of the human α1E (Cav2.3)."
"In motor neurons, subsurface cisternae of the ER, a region where Sig-1R interacts with IP 3 R type 3, show enrichment in Sig-1R. Calcium release from IP 3 R may promote conductance of potassium channels such as small conductance calcium-activated potassium channels (SK) channels (61) ."
"258 MILLER TABLE I The Total and Bound Vitamin Bii Concentration of Several Sera and Batches of Pooled Plasma Bi2 Activity Sample Per cent combined Total Bound mp.s."
"Here, we show that FMRP binds the mRNA of the R-type voltage-gated calcium channel Cav2.3 in mouse brain synaptoneurosomes and represses Cav2.3 translation under basal conditions."
"As shown in XREF_FIG, treatment with rTF, rFVIIa and PAR2 agonist significantly decreased LC3A and B-II expression, whereas no significant change in cells treated with thrombin and PAR1 was observed."
"Alpha- to beta-(dmes) BiI (5) (dmes = dimethyl (2-ethylammonium) sulfonium dication) : umbrella reversal of sulfonium in the solid state and short I.."
"These findings link Cacna1e function to leptin mediated POMC neuron excitability and glucose homeostasis and may provide a target for the treatment of diabetes."
"These findings link Cacna1e function to leptin mediated POMC neuron excitability and glucose homeostasis and may provide a target for the treatment of diabetes."
"The CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E and CACNA1G genes produce various isoform of alpha1 subunit including A, B, C, D, E and G, respectively."
"In motor neurons, subsurface cisternae of the ER, a region where Sig-1R interacts with IP 3 R type 3, show enrichment in Sig-1R. Calcium release from IP 3 R may promote conductance of potassium channels such as small conductance calcium-activated potassium channels (SK) channels (61) ."
"258 MILLER TABLE I The Total and Bound Vitamin Bii Concentration of Several Sera and Batches of Pooled Plasma Bi2 Activity Sample Per cent combined Total Bound mp.s."
"The K 4 BiI 7 -added electrolyte enables Li metal anode to display a stable cycling for over 600 cycles at 1.0 mA cm -2 / 1.0 mAh cm -2 and over 400 cycles at 5.0 mA cm -2 / 5.0 mAh cm -2."
"RT-PCR mapping of the RNA products revealed that the antisense activity resulted in the formation of three major products : aII, xII, and bII NATs (antisense products of the IIa, IIx, and IIb genes, respectively)."
"However, we also observed that the CAD/MI GWAS SNP at this locus, rs17087335, is in tight LD with lead trans-eQTLs targeting expression of trans-eGenes GDAP1 (ganglioside induced differentiation associated protein 1 on chr 8; P < 1E-20) and CACNA1E."
"Here, we show that FMRP binds the mRNA of the R-type voltage-gated calcium channel Cav2.3 in mouse brain synaptoneurosomes and represses Cav2.3 translation under basal conditions."
"Co-expression of Rpn13 150-407 and the MLPs alone led to a reduction in detectable amounts of OP91and OPG-TASK 85 (XREF_FIG A and B, lanes 1 and 4, see also accompanying graphs); suggesting that the Rpn13 150-407 -mediated displacement of endogenous SGTA (XREF_FIG Bii) reduces steady-state levels of MLP."
"Here we provide in-vitro evidence of a direct interaction between both a-tubulin and bII-tubulin with VDAC2 in un treated single extensor digitorum longus fibres."
"While chloroquine led to a significant increase in LC3A and B-II levels in most cells, C-6 only induced a small increase in LC3A and B-II levels in the T47D cells, but not the other cell types evaluated."
"XREF_FIG, overexpression of constitutively-active Akt by transfecting the cells with pcDNA3-CA-Akt plasmid decreased LC3A and B-II expression, and this effect was enhanced by ibrutinib treatment."
"HI injury reduced LC3A and B-I (P = 0.002, F = 4.77, SEHI vs SE, Figure XREF_FIG) and LC3A and B-II (P = 0.047, F = 1.24, SEHI vs SE, Figure XREF_FIG) protein levels in the SEHI group only."
"Ang II enhanced the podocyte expression of the autophagic proteins, LC3A and B-II and beclin-1, and also increased the number of autophagosomes compared with control cells at early phase of 12 hours in a dose dependent manner."
"Here we provide in-vitro evidence of a direct interaction between both a-tubulin and bII-tubulin with VDAC2 in un treated single extensor digitorum longus fibres."