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databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading

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CACNA1E increases the amount of calcium(2+).
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CACNA1E increases the amount of calcium(2+). 1 / 1
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"Future studies will determine if the CACNA1E SNP rs679931 (TT) modulates the expression or function of human Ca V 2.3, which glucose sensitive cells CaV2.3 influences and how this modulates human glucose homeostasis."
CACNA1E activates calcium(2+).
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"CACNA1E was shown to mediate a significant fraction of R-type Ca 2+ currents, specifically within the hippocampus [XREF_BIBR]."
MTOR affects CACNA1E
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MTOR increases the amount of CACNA1E.
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MTOR increases the amount of CACNA1E. 2 / 2
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"In addition, the drastically suppressed LC3A and B-II levels in Hep3B cells treated with rTF, rFVII or PAR2 agonist were rescued by mTOR siRNA transfection (XREF_FIG)."
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"Furthermore, mTOR silencing restored the impaired expression of LC3A and B-II in TF-, FVII- or PAR2 treated Hep3B cells and activated autophagy."
MTOR decreases the amount of CACNA1E.
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MTOR decreases the amount of CACNA1E. 1 / 1
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"The LC3A and B-II expression levels, which drastically inhibited by rTF, rFVII or PAR2 activation, were fully rescued by mTOR knockdown in vitro, suggesting mTOR signaling pathway could have a key role in tumor malignancy through TF/FVII/PAR2 mediated suppression of autophagy."
CACNA1E affects INS
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CACNA1E inhibits INS.
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CACNA1E inhibits INS. 2 / 2
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"We conclude that genetic variation in the CACNA1E gene contributes to an increased risk of the development of type 2 diabetes by reducing insulin secretion."
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"In addition, upregulated miRNAs inhibited insulin secretion via calcium voltage gated channel subunit alpha1 E (CACNA1E), a voltage dependent R type calcium channel."
CACNA1E activates INS.
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CACNA1E activates INS. 1 / 1
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"A functional variant in CACNA1E contributes to type 2 diabetes susceptibility by affecting insulin action."
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Bisphenol A decreases the amount of CACNA1E.
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Bisphenol A decreases the amount of CACNA1E. 1 / 1
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"The decrease in both the R-type Ca 2+ currents and Cacna1e gene expression by 1nM BPA implicated ERbeta."
Bisphenol A activates CACNA1E.
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"This can explain why BPA triggers transcriptional downregulation of Cacna1e at low dose such as 1nM."
EFHC1 affects CACNA1E
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hprd
No evidence text available
biogrid
No evidence text available
CACNA1E affects autophagy
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CACNA1E inhibits autophagy.
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"The LC3A and B-II expression levels, which drastically inhibited by rTF, rFVII or PAR2 activation, were fully rescued by mTOR knockdown in vitro, suggesting mTOR signaling pathway could have a key role in tumor malignancy through TF/FVII/PAR2 mediated suppression of autophagy."
CACNA1E activates autophagy.
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"The LC3A and B-II expression levels, which drastically inhibited by rTF, rFVII or PAR2 activation, were fully rescued by mTOR knockdown in vitro, suggesting mTOR signaling pathway could have a key role in tumor malignancy through TF/FVII/PAR2 mediated suppression of autophagy."
CACNA1E affects EFHC1
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hprd
No evidence text available
biogrid
No evidence text available
Tenovin-6 affects CACNA1E
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Tenovin-6 activates CACNA1E. 1 / 1
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"XREF_BIBR, XREF_BIBR, XREF_BIBR We found that tenovin-6 treatment significantly increased LC3A and B-II in wild-type but not ATG5 -/- and ATG7 -/- MEF cells (XREF_FIG)."
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"With regards to voltage gated calcium (Ca 2+) channels (XREF_FIG), Na + deficiency significantly upregulated Cacna1i (Ca v 3.3; T-type), Cacna1e (Ca v 2.3; R-type), Cacna1c (Ca v 1.2; L-type) and Cacna1b (Ca v 2.2; N-type)."
Sirolimus affects CACNA1E
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Sirolimus increases the amount of CACNA1E. 1 / 1
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"We further found that the LC3A and B-II expression was induced by sirolimus, a main selective inhibitor of mTOR, and the sirolimus induced LC3A and B-II was partially reduced by rTF exposure, but was fully suppressed in the presence of rFVII or PAR2 agonist (see XREF_SUPPLEMENTARY)."
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sparser
"These findings strongly suggest that both H179 and H183 in the IS3-IS4 loop are essential structural determinants required for nickel sensitive inhibition of the Cav2.3."
MiR-96-5p affects CACNA1E
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MiR-96-5p inhibits CACNA1E. 1 / 1
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"For insulin secretion, the upregulation of miR-96-5p represses CACNA1E and then results in impaired insulin secretion."
Ibrutinib affects CACNA1E
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Ibrutinib decreases the amount of CACNA1E. 1 / 1
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"A combined ibrutinib and 3MA treatment decreased the LC3A and B-II levels, indicating that ibrutinib induced autophagy in GBM cells."
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Transcriptionally active hsa-miR-892b decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-6840-5p decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-6815-3p decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-605-5p decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-5587-3p decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-541-3p decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-4286 decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-335-3p decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-30e-3p decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-30d-3p decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-30a-3p decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-1224-3p decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
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Transcriptionally active hsa-miR-106b-3p decreases the amount of CACNA1E. 1 / 1
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biopax:mirtarbase
No evidence text available
Curcumin affects CACNA1E
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Curcumin increases the amount of CACNA1E. 1 / 1
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"suggested that curcumin or solid lipid curcumin particles treatment could increase the levels of LC3A and B-II and Beclin-1, indicating that maintenance or restoration of heat shock proteins and regulation of autophagy-lysosomal pathways by curcumin may provide a promising strategy to degrade Abeta-aggregates from neurons in the AD brain."
VPS13C affects CACNA1E
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"As shown in XREF_FIG, B and C, VPS13C was barely detected in islets isolated from betaVps13cKO mice (XREF_FIG and Ci) and levels of Vps13c mRNA were significantly reduced (XREF_FIG, Bii and Cii) by> 80%."
TRPM3WT affects CACNA1E
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TRPM3WT activates CACNA1E. 1 / 1
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"However, expression of TRPM3WT but not TRPM3DN in HEK293 cells induced accumulation of LC3A and B-II (XREF_SUPPLEMENTARY), suggesting that increased expression of TRPM3 may force a connection with the autophagic pathway."
TRPM3DN affects CACNA1E
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TRPM3DN activates CACNA1E. 1 / 1
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"However, expression of TRPM3WT but not TRPM3DN in HEK293 cells induced accumulation of LC3A and B-II (XREF_SUPPLEMENTARY), suggesting that increased expression of TRPM3 may force a connection with the autophagic pathway."
STIM1 affects CACNA1E
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"In a follow-up study, the same group identified an enhanced interaction of STIM1 with InsP 3 R type 3 in cells coexpressing polycystin-1."
SRC affects CACNA1E
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SRC phosphorylates CACNA1E. 1 / 1
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rlimsp
"The effect of Vc1.1 on Cav2.3 channels was completely VI and depended on the presence of specific c-Src phosphorylation sites in the C terminus of the human α1E (Cav2.3)."
SIGMAR1 affects CACNA1E
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"In motor neurons, subsurface cisternae of the ER, a region where Sig-1R interacts with IP 3 R type 3, show enrichment in Sig-1R. Calcium release from IP 3 R may promote conductance of potassium channels such as small conductance calcium-activated potassium channels (SK) channels (61) ."
MILLER TABLE I affects CACNA1E
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CACNA1E binds MILLER TABLE I. 1 / 1
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"258 MILLER TABLE I The Total and Bound Vitamin Bii Concentration of Several Sera and Batches of Pooled Plasma Bi2 Activity Sample Per cent combined Total Bound mp.s."
MAPK1 affects CACNA1E
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Modified MAPK1 increases the amount of CACNA1E. 1 / 1
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"Suppression of MAPK1 expression inhibited the gene and protein expression of Cacna1b, Cacna1e, Grm1, and Grm1 (P < 0.001, Fig."
HSPA1A affects CACNA1E
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hprd
No evidence text available
GNB2 affects CACNA1E
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biogrid
No evidence text available
FMR1 affects CACNA1E
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sparser
"Here, we show that FMRP binds the mRNA of the R-type voltage-gated calcium channel Cav2.3 in mouse brain synaptoneurosomes and represses Cav2.3 translation under basal conditions."
F2R affects CACNA1E
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F2R inhibits CACNA1E. 1 / 1
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"As shown in XREF_FIG, treatment with rTF, rFVIIa and PAR2 agonist significantly decreased LC3A and B-II expression, whereas no significant change in cells treated with thrombin and PAR1 was observed."
CACNA1E affects sulfonium
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"Alpha- to beta-(dmes) BiI (5) (dmes = dimethyl (2-ethylammonium) sulfonium dication) : umbrella reversal of sulfonium in the solid state and short I.."
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"These findings link Cacna1e function to leptin mediated POMC neuron excitability and glucose homeostasis and may provide a target for the treatment of diabetes."
CACNA1E affects growth
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CACNA1E inhibits growth. 1 / 1
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sparser
"Both BII and BIE inhibited the growth of other microorganisms."
CACNA1E affects glucose
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"These findings link Cacna1e function to leptin mediated POMC neuron excitability and glucose homeostasis and may provide a target for the treatment of diabetes."
CACNA1E affects alpha1 subunit
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CACNA1E activates alpha1 subunit. 1 / 1
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"The CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E and CACNA1G genes produce various isoform of alpha1 subunit including A, B, C, D, E and G, respectively."
CACNA1E affects STIM1
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sparser
"In a follow-up study, the same group identified an enhanced interaction of STIM1 with InsP 3 R type 3 in cells coexpressing polycystin-1."
CACNA1E affects SIGMAR1
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sparser
"In motor neurons, subsurface cisternae of the ER, a region where Sig-1R interacts with IP 3 R type 3, show enrichment in Sig-1R. Calcium release from IP 3 R may promote conductance of potassium channels such as small conductance calcium-activated potassium channels (SK) channels (61) ."
CACNA1E affects MILLER TABLE I
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CACNA1E binds MILLER TABLE I. 1 / 1
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"258 MILLER TABLE I The Total and Bound Vitamin Bii Concentration of Several Sera and Batches of Pooled Plasma Bi2 Activity Sample Per cent combined Total Bound mp.s."
CACNA1E affects Leu-Ile
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"The K 4 BiI 7 -added electrolyte enables Li metal anode to display a stable cycling for over 600 cycles at 1.0 mA cm -2 / 1.0 mAh cm -2 and over 400 cycles at 5.0 mA cm -2 / 5.0 mAh cm -2."
CACNA1E affects IIb genes
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CACNA1E activates IIb genes. 1 / 1
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"RT-PCR mapping of the RNA products revealed that the antisense activity resulted in the formation of three major products : aII, xII, and bII NATs (antisense products of the IIa, IIx, and IIb genes, respectively)."
CACNA1E affects HSPA1A
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hprd
No evidence text available
CACNA1E affects GNB2
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biogrid
No evidence text available
CACNA1E affects GDAP1
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CACNA1E increases the amount of GDAP1. 1 / 1
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"However, we also observed that the CAD/MI GWAS SNP at this locus, rs17087335, is in tight LD with lead trans-eQTLs targeting expression of trans-eGenes GDAP1 (ganglioside induced differentiation associated protein 1 on chr 8; P < 1E-20) and CACNA1E."
CACNA1E affects FMR1
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sparser
"Here, we show that FMRP binds the mRNA of the R-type voltage-gated calcium channel Cav2.3 in mouse brain synaptoneurosomes and represses Cav2.3 translation under basal conditions."
CACNA1E affects Cerebratulus toxin B-IV
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CACNA1E activates Cerebratulus toxin B-IV. 1 / 1
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"The sequence analysis of B-II led us to re-examine the sequence of Cerebratulus toxin B-IV."
CACNA1E affects CSRP3
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CACNA1E decreases the amount of CSRP3. 1 / 1
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"Co-expression of Rpn13 150-407 and the MLPs alone led to a reduction in detectable amounts of OP91and OPG-TASK 85 (XREF_FIG A and B, lanes 1 and 4, see also accompanying graphs); suggesting that the Rpn13 150-407 -mediated displacement of endogenous SGTA (XREF_FIG Bii) reduces steady-state levels of MLP."
CACNA1E affects CASP3, CASP9, and PARP1
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sparser
"Western blot analysis revealed the presence of cleaved forms of caspase 3, caspase 9, and PARP in RAW 264.7 cells infected with the R type ( xref )."
CACNA1E affects BK
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CACNA1E binds BK. 1 / 1
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sparser
"This regulation occurs through a novel functional and physical interaction between Cav2.3 and the calcium-gated potassium channel BK."
CACNA1E affects A
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"Here we provide in-vitro evidence of a direct interaction between both a-tubulin and bII-tubulin with VDAC2 in un treated single extensor digitorum longus fibres."
C6 affects CACNA1E
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C6 increases the amount of CACNA1E. 1 / 1
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"While chloroquine led to a significant increase in LC3A and B-II levels in most cells, C-6 only induced a small increase in LC3A and B-II levels in the T47D cells, but not the other cell types evaluated."
BK affects CACNA1E
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CACNA1E binds BK. 1 / 1
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sparser
"This regulation occurs through a novel functional and physical interaction between Cav2.3 and the calcium-gated potassium channel BK."
AKT affects CACNA1E
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Modified AKT decreases the amount of CACNA1E. 1 / 1
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"XREF_FIG, overexpression of constitutively-active Akt by transfecting the cells with pcDNA3-CA-Akt plasmid decreased LC3A and B-II expression, and this effect was enhanced by ibrutinib treatment."
AKAP4 affects CACNA1E
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"HI injury reduced LC3A and B-I (P = 0.002, F = 4.77, SEHI vs SE, Figure XREF_FIG) and LC3A and B-II (P = 0.047, F = 1.24, SEHI vs SE, Figure XREF_FIG) protein levels in the SEHI group only."
AGT affects CACNA1E
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AGT increases the amount of CACNA1E. 1 / 1
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"Ang II enhanced the podocyte expression of the autophagic proteins, LC3A and B-II and beclin-1, and also increased the number of autophagosomes compared with control cells at early phase of 12 hours in a dose dependent manner."
A affects CACNA1E
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"Here we provide in-vitro evidence of a direct interaction between both a-tubulin and bII-tubulin with VDAC2 in un treated single extensor digitorum longus fibres."
CACNA1E affects calcium(2+), and calcium(2+)
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CACNA1E catalyzes the conversion of calcium(2+) into calcium(2+). 4 / 4
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biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available