INDRA statements for CACNA1C

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
reading
CACNA1C affects calcium(2+)
4 | 26
CACNA1C activates calcium(2+).
| 17
CACNA1C activates calcium(2+). 14 / 14
| 14
reach
"Specifically, mutations in the CACNA1C gene cause an abnormal function of this calcium channel, and have been associated with BP, SCZ and another syndromic form of ASD, Timothy syndrome (TS)."
30185603
reach
"Timothy syndrome (TS) is an autosomal dominant disorder, and is caused by a mutation in the cacna1c gene encoding the calcium channel Ca v 1.2 subunit."
22771169
reach
"Following the designation introduced by Tang, et al. [XREF_BIBR], we designed qPCR primers to assay three classes of splice variants previously shown to encode distinct CACNA1C isoforms that produce calcium channel subunits with different activation potentials."
27276213
reach
"LQT8 and Timothy syndrome are caused by mutation in the CACNA1C gene encoding the L-type Ca 2+ channel."
23015789
reach
"Alternative splicing in CACNA1C, encoding the Ca V 1.2 pore forming subunit alpha1 C, modulates the function of Ca V 1.2 calcium channels."
28949795
reach
"Longer exposure to METH (20min or 48h) selectively up-regulates the expression of only the CACNA1C gene, thus increasing the number of L-type Ca (2+) channels."
25807982
reach
"In rat smooth muscle cells alpha5beta1 integrin signalling has been described to promote CACNA1C mediated calcium entry in cells through Src phosphorylation of CACNA1C on Y2122."
27910855
reach
"In previous simulation studies, it has been shown that changes in I CaL due to gain-of-function mutations in CACNA1C prolongs action potential duration linked to early afterdepolarizations, and increases SR calcium content which is then responsible for spontaneous calcium release and delayed afterdepolarizations."
29046645
reach
"CACNA1C, a calcium channel gene, mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium dependent processes, including muscle contraction, hormone and neurotransmitter release, gene expression, cell motility, cell division and cell death."
23650531
reach
"Longer exposure to METH (20 min or 48 hr) selectively upregulates the expression of only the CACNA1C gene, thus increasing the number of L-type Ca 2+ channels."
25807982
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR In particular, induced neurons from subjects with the risk CACNA1C single nucleotide polymorphism show greater expression of calcium channel subunit mRNA, and increased calcium signalling, compared to those without the risk allele."
27240535
reach
"Mutations in CACNA1C cause a significant increase in the sustained intracellular calcium rise, leading to changes in gene expression and altered neuronal differentiation, partly through changes in early growth response protein (Egr1) transcription factor levels [XREF_BIBR]."
23241247
reach
"Alternative splicing in CACNA1C, encoding the Ca V 1.2 pore forming subunit alpha1 C, modulates the function of Ca V 1.2 calcium channels."
28949795
reach
"Timothy syndrome (TS) is an autosomal dominant disorder, and is caused by a mutation in the cacna1c gene encoding the calcium channel Ca v 1.2 subunit."
22771169
Mutated CACNA1C activates calcium(2+). 3 / 3
| 3
reach
"Third, the CACNA1C mutation increased intracellular calcium concentration, which influenced cardiac mechanics."
27502440
reach
"Changes in I CaL, sodium-calcium exchanger current (I NCX), I rel, cytoplasmic calcium concentration ([Ca2+] i) and SR calcium concentration ([Ca2+] SR) were used to analyze CACNA1C mutations induced calcium handling."
29046645
reach
"It has been demonstrated that CACNA1C mutations caused a gain-of-function of Ca V 1.2 L-type calcium channel, leading to an increased calcium influx, resulting in a dramatic AP prolongation XREF_BIBR XREF_BIBR XREF_BIBR and afterdepolarization triggered activity XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
27502440
CACNA1C inhibits calcium(2+).
| 6
CACNA1C inhibits calcium(2+). 5 / 5
| 5
reach
"In summary, the combined effects of the CACNA1C variant to diminish voltage dependent inactivation of Ca V 1.2 and increase window current expand our appreciation of mechanisms by which a gain of function of Ca V 1.2 can contribute to QT prolongation."
25184293
reach
"Nfat5 knockdown suppresses Cacna1c expression, decreases L-type calcium current, and results in non beating ventricle."
27368804
reach
"Because the CACNA1C risk allele is expected to produce loss of calcium channel function, we would expect BD patients without the risk allele to preferentially respond to CCB treatment."
23979604
reach
"The Dolmetsch lab studied induced neurons from patients with Timothy Syndrome (TS), an extremely rare disorder associated with autism and cardiac abnormalities due to a mutation in the CACNA1C gene causing decreased inactivation of an L-type calcium channel subunit."
24074462
reach
"As illustrated in XREF_FIG, expressions of SERCA2 (at gene and protein levels) and Cacna1c (at gene level) decreased in the hearts of 16-week high fat diet fed animals, suggesting altered myocardial Ca 2+ handling."
26840416
CACNA1C-Q1916R inhibits calcium(2+). 1 / 1
| 1
reach
"The functional studies, via the exogenous expression approach, revealed that the CACNA1C Q1916R mutation led to a decreasing L-type calcium current and the protein expression defect."
28493952
CACNA1C increases the amount of calcium(2+).
| 3
CACNA1C increases the amount of calcium(2+). 3 / 3
| 3
reach
"In addition, we observe pathway hits in calcium signaling, specifically at RhoA, AKAP6, and calcium channels CACNA1C and CACNA2D3, all of which modulate calcium levels, which, in turn, through calcinuerin signaling, regulate the transcriptional activity of another associated gene in the calcium signaling pathway, NF-AT."
18722519
reach
"In this paradigm of oxidative cell death, we found that both Cacna1c gene silencing and pharmacological inhibition of LTCC using nimodipine significantly diminished the glutamate induced rise in mitochondrial calcium levels."
29760952
reach
"Our findings are further strengthened by accumulating evidence that RYR3 modulates Abeta plaque deposition and that CACNA1C increases intracellular calcium levels in the presence of Abeta."
24026422
ANK3 affects CACNA1C
| 15 2
ANK3 binds CACNA1C.
| 15
CACNA1C binds ANK3. 12 / 12
| 12
sparser
"In summary, our study provides further evidence for the positive association of CACNA1C and ANK3 with SZ."
26227746
sparser
"Based on a literature search, none of the predicted proteins that interact with ANK3 and CACNA1C are associated with BD or other neuropsychiatric disorders, although some are linked to epilepsy ( xref ; xref )."
29684488
sparser
"Based on the hypothesis that both schizophrenia (SZ) and BD may share some common genetic risk factors, we investigated the association of CACNA1C and ANK3 with SZ using meta-analytic techniques, combining all published data up to April 2015."
26227746
sparser
"As a result, this may lead to altered protein levels, thus affecting ANK3 and CACNA1C protein-protein interactions."
29684488
sparser
"Previous studies have shown rs9804190 in ANK3 and rs1006737 in CACNA1C are associated with altered expression of ANK3 and CACNA1C mRNA levels ( xref ; xref )."
29684488
sparser
"Excluding samples reported in that analysis xref , our bipolar sample was associated at CACNA1C (p=2.3×10 −4 ) and ITIH3/4 (p=0.0033) but not ANK3 ."
22614287
sparser
"While the role of oxytocin and dopamine is still being investigated in BD, our analysis suggests that ANK3 and CACNA1C may interact with proteins that play important roles in the etiology of BD, and alterations in ANK3 and CACNA1C protein expression may be detrimental to the endogenous function of these pathways."
29684488
sparser
"Interestingly, genetic association studies of schizophrenia (SCZ), which is another major psychotic disorder, have also revealed that the BD risk SNPs, such as CACNA1C and ANK3 , are associated with SCZ xref ."
23967141
sparser
"We used STRING to determine the possible protein-protein (and genetic) interactions that may be adversely affected by changes in ANK3 and CACNA1C protein levels ( xref , xref )."
29684488
sparser
"Since altered expression of these genes may affect ANK3 and CACNA1C native protein-protein (or genetic) interactions, we utilized STRING to visualize ANK3 and CACNA1C primary and secondary interacting partners."
29684488
sparser
"These findings that favor the hypothesis of a common set of pathological mechanisms accounting for BPD and MDD led us to investigate whether the recently identified genes, ANK3 and CACNA1C, associated with BPD ( Ferreira et al., 2008 ) are associated with MDD in our two depression samples."
22647524
sparser
"In bipolar disorder, association with SNPs of ANK3 and CACNA1C was found by the combined analysis of three sample sets, which was consistent across three sample sets."
19507497
CACNA1C binds EGFR and ANK3. 1 / 1
| 1
sparser
"While we could not confirm an association of ANK3, CACNA1C, and EGFR with BPD, 10 SNPs in DGKH, CMTM8, and NPAS3 were nominally associated with disease, with two DGKH markers surviving correction for multiple testing."
21654738
CACNA1C binds ANK3 and ITIH3. 1 / 1
| 1
sparser
"When applied in BPD, systems biology revealed the implication of a number of genes including interactions of CACNA1C, ANK3, and ITIH3-4 genes via genetic association analysis."
23269912
CACNA1C binds CMTM8, DGKH, EGFR, and ANK3. 1 / 1
| 1
sparser
"To address these issues, we genotyped SNPs in ANK3, CACNA1C, CMTM8, DGKH, EGFR, and NPAS3, which were significantly associated with BPD in previous GWAS, in a sample of 380 BPD patients."
21654738
ANK3 activates CACNA1C.
| 2
ANK3 activates CACNA1C. 2 / 2
| 2
reach
"Similarly, the well documented functions of ankyrin G in localizing inhibitory GABAergic interneuron synapses to the AIS of excitatory neurons, as well as mediating activity dependent AIS relocation along axons, further supports a common mechanism of ANK3 and CACNA1C in regulation of neuronal excitability."
23025490
reach
"We report support for two of the three most strongly associated chromosomal regions in the Ferreira study, CACNA1C (rs1006737, P = 4.09 x 10 (-4)) and 15q14 (rs2172835, P = 0.043) but not ANK3 (rs10994336, P = 0.912)."
23070075
CACNA1C affects ANK3
| 15
CACNA1C binds ANK3. 12 / 12
| 12
sparser
"In summary, our study provides further evidence for the positive association of CACNA1C and ANK3 with SZ."
26227746
sparser
"Based on a literature search, none of the predicted proteins that interact with ANK3 and CACNA1C are associated with BD or other neuropsychiatric disorders, although some are linked to epilepsy ( xref ; xref )."
29684488
sparser
"Based on the hypothesis that both schizophrenia (SZ) and BD may share some common genetic risk factors, we investigated the association of CACNA1C and ANK3 with SZ using meta-analytic techniques, combining all published data up to April 2015."
26227746
sparser
"As a result, this may lead to altered protein levels, thus affecting ANK3 and CACNA1C protein-protein interactions."
29684488
sparser
"Previous studies have shown rs9804190 in ANK3 and rs1006737 in CACNA1C are associated with altered expression of ANK3 and CACNA1C mRNA levels ( xref ; xref )."
29684488
sparser
"Excluding samples reported in that analysis xref , our bipolar sample was associated at CACNA1C (p=2.3×10 −4 ) and ITIH3/4 (p=0.0033) but not ANK3 ."
22614287
sparser
"While the role of oxytocin and dopamine is still being investigated in BD, our analysis suggests that ANK3 and CACNA1C may interact with proteins that play important roles in the etiology of BD, and alterations in ANK3 and CACNA1C protein expression may be detrimental to the endogenous function of these pathways."
29684488
sparser
"Interestingly, genetic association studies of schizophrenia (SCZ), which is another major psychotic disorder, have also revealed that the BD risk SNPs, such as CACNA1C and ANK3 , are associated with SCZ xref ."
23967141
sparser
"We used STRING to determine the possible protein-protein (and genetic) interactions that may be adversely affected by changes in ANK3 and CACNA1C protein levels ( xref , xref )."
29684488
sparser
"Since altered expression of these genes may affect ANK3 and CACNA1C native protein-protein (or genetic) interactions, we utilized STRING to visualize ANK3 and CACNA1C primary and secondary interacting partners."
29684488
sparser
"These findings that favor the hypothesis of a common set of pathological mechanisms accounting for BPD and MDD led us to investigate whether the recently identified genes, ANK3 and CACNA1C, associated with BPD ( Ferreira et al., 2008 ) are associated with MDD in our two depression samples."
22647524
sparser
"In bipolar disorder, association with SNPs of ANK3 and CACNA1C was found by the combined analysis of three sample sets, which was consistent across three sample sets."
19507497
CACNA1C binds EGFR and ANK3. 1 / 1
| 1
sparser
"While we could not confirm an association of ANK3, CACNA1C, and EGFR with BPD, 10 SNPs in DGKH, CMTM8, and NPAS3 were nominally associated with disease, with two DGKH markers surviving correction for multiple testing."
21654738
CACNA1C binds ANK3 and ITIH3. 1 / 1
| 1
sparser
"When applied in BPD, systems biology revealed the implication of a number of genes including interactions of CACNA1C, ANK3, and ITIH3-4 genes via genetic association analysis."
23269912
CACNA1C binds CMTM8, DGKH, EGFR, and ANK3. 1 / 1
| 1
sparser
"To address these issues, we genotyped SNPs in ANK3, CACNA1C, CMTM8, DGKH, EGFR, and NPAS3, which were significantly associated with BPD in previous GWAS, in a sample of 380 BPD patients."
21654738
CACNA1C affects TYMS
| 5 8
CACNA1C activates TYMS.
| 8
CACNA1C activates TYMS. 6 / 6
| 6
reach
"TS is caused by p.Gly406Arg mutation in the CACNA1C."
23678275
reach
"Timothy syndrome (TS) is an autosomal dominant disorder, and is caused by a mutation in the cacna1c gene encoding the calcium channel Ca v 1.2 subunit."
22771169
reach
"A point mutation in the gene encoding Cav1.2 (CACNA1C) causes Tymothy syndrome (TS), a multisystem disorder featuring cardiac arrhythmias, autism spectrum disorder (ASD) and adrenal gland dysfunction."
30629744
reach
"This is the same syndrome caused by dominant loss-of-function alleles at CACNA1C, where a gain-of-function allele causes TS."
24204377
reach
"Timothy syndrome type 1 is caused by a recurrent de novo mutation (p.Gly406Arg) in exon 8A of the L-type calcium channel gene CACNA1C."
26227324
reach
"The same rare specific allele of CACNA1C, a gene that encodes the " cardiac expressed " voltage gated calcium channel, was found to cause TS in all 12 original de novo unrelated cases, suggesting that there must be only a very limited range of changes to channel function that create the diverse tissue phenotypes."
24204377
Mutated CACNA1C activates TYMS. 2 / 2
| 2
reach
"Timothy Syndrome (TS) is caused by very rare exonic mutations of the CACNA1C gene that produce delayed inactivation of Cav1.2voltage-gated calcium channels during cellular action potentials, with greatly increased influx of calcium into the activated cells."
23979604
reach
"TS is caused by mutations of the CACNA1C gene, which encodes L-type calcium channel Ca (V) 1.2."
26301350
CACNA1C binds TYMS.
| 5
TYMS binds CACNA1C. 5 / 5
| 5
sparser
"Interestingly, recent identification of the CACNA1C-I116V mutation in a patient with LQTS offers a genetic enigma as it localizes to the identical residue as the CACNA1C-I1166T mutation which is associated with TS [37] ."
27390944
sparser
"Classically, TS is associated with mutations CACNA1C-G402S and G406R [5,6] ."
27390944
sparser
"In addition to disease with impaired cardiac repolarization, such as TS and LQTS, mutations in CACNA1C have been associated with other arrhythmias, such as Brugada syndrome and early repolarization syndrome [23] ."
27390944
sparser
"In contrast, heterozygous mutations in the CACNA1C gene (Cav1.2) are associated with a rare childhood multi-organ disorder called TS."
25633834
sparser
"Interestingly, recent identification of the CACNA1C-I116V mutation in a patient with LQTS offers a genetic enigma as it localizes to the identical residue as the CACNA1C-I1166T mutation which is associated with TS [ xref ]."
27390944
QKI affects CACNA1C
| 5 7
QKI binds CACNA1C.
| 5 3
CACNA1C binds QKI. 8 / 8
| 5 3
reach
"RNA immunoprecipitation (RIP) assay showed that QKI bound to CACNA1C mRNA, which was inhibited by tachypacing."
27660282
sparser
"Meanwhile, QKI overexpression in atrial myocytes restored the LPS-stimulated macrophage-induced electrical remodeling through enhanced binding of QKI to CACNA1C mRNA, which upregulated the expression of CACNA1C as well as I Ca-L . In contrast, QKI knockout inhibited CACNA1C expression."
27660282
sparser
"RNA immunoprecipitation (RIP) assay showed that QKI bound to CACNA1C mRNA, which was inhibited by tachypacing (Fig.  xref c, d)."
27660282
reach
"The main findings of the present study are : (1) increased pro inflammatory macrophages were found in the atria of AF patients, and HL-1 cell tachypacing induced pro inflammatory macrophage polarization; (2) pro inflammatory macrophage polarization played a major role in atrial electrical remodeling as evidenced by the increased incidence of AF in chronic LPS treatment in mice and canines, which was inhibited by the depletion of LPS stimulated macrophages; (3) the effect of LPS stimulated macrophages on electrical remodeling was mediated by IL-1beta secretion, which inhibited QKI expression in atrial myocytes; (4) QKI bound to CACNA1C mRNA and regulated the level of I Ca-L; and (5) the transcription factor Satb1 mediated QKI expression."
27660282
sparser
"The main findings of the present study are: (1) increased pro-inflammatory macrophages were found in the atria of AF patients, and HL-1 cell tachypacing induced pro-inflammatory macrophage polarization; (2) pro-inflammatory macrophage polarization played a major role in atrial electrical remodeling as evidenced by the increased incidence of AF in chronic LPS treatment in mice and canines, which was inhibited by the depletion of LPS-stimulated macrophages; (3) the effect of LPS-stimulated macrophages on electrical remodeling was mediated by IL-1β secretion, which inhibited QKI expression in atrial myocytes; (4) QKI bound to CACNA1C mRNA and regulated the level of I Ca-L ; and (5) the transcription factor Satb1 mediated QKI expression."
27660282
sparser
"Bioinformatics predicted that QKI could bind to CACNA1C mRNA, which was confirmed by RIP in our study."
27660282
reach
"Meanwhile, QKI overexpression in atrial myocytes restored the LPS stimulated macrophage induced electrical remodeling through enhanced binding of QKI to CACNA1C mRNA, which upregulated the expression of CACNA1C as well as I Ca-L."
27660282
sparser
"Recently, bioinformatics predicted that QKI could bind to CACNA1C mRNA, the α1C subunit of L-type calcium channel [ xref ], indicating a potential role for QKI in AF."
27660282
QKI increases the amount of CACNA1C.
| 4
QKI increases the amount of CACNA1C. 3 / 3
| 3
reach
"We also found that overexpression of QKI elevated CACNA1C mRNA and protein expression, while QKI knockdown mediated by the CRISPR and Cas9 system inhibited CACNA1C expression in both HL-1 and primary cultured cardiomyocytes."
27660282
reach
"In contrast, QKI knockout inhibited CACNA1C expression."
27660282
reach
"Furthermore, we showed that QKI not only upregulated CACNA1C expression, but also enhanced the level of I Ca-L, which plays important roles in the pathogenesis of AF."
27660282
QKI bound to CACNA1C increases the amount of CACNA1C. 1 / 1
| 1
reach
"Meanwhile, QKI overexpression in atrial myocytes restored the LPS stimulated macrophage induced electrical remodeling through enhanced binding of QKI to CACNA1C mRNA, which upregulated the expression of CACNA1C as well as I Ca-L."
27660282
PRKACA affects CACNA1C
4 2 5 |
PRKACA phosphorylates CACNA1C.
4 1 2 |
PRKACA phosphorylates CACNA1C on S1981. 2 / 2
2 |
hprd
No evidence text available
8612821
hprd
No evidence text available
9247274
PRKACA phosphorylates CACNA1C on S1627. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKACA phosphorylates CACNA1C on S1897. 1 / 1
1 |
signor
"These findings reveal an essential role for _1C phosphorylation at Ser1928 in stimulating CaV1.2 channel activity and vasoconstriction by AKAP-targeted PKA upon exposure to increased glucose and in diabetes"
28119464
PRKACA phosphorylates CACNA1C on S1700. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKACA phosphorylates CACNA1C on S1928. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKACA phosphorylates CACNA1C on S1535. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKACA binds CACNA1C.
3 |
CACNA1C binds PRKACA. 3 / 3
3 |
hprd
No evidence text available
9247274
hprd
No evidence text available
8612821
hprd
No evidence text available
8664319
PRKACA activates CACNA1C.
1 |
PRKACA activates CACNA1C. 1 / 1
1 |
signor
"These findings reveal an essential role for _1C phosphorylation at Ser1928 in stimulating CaV1.2 channel activity and vasoconstriction by AKAP-targeted PKA upon exposure to increased glucose and in diabetes"
28119464
SNP affects CACNA1C
| 9
CACNA1C binds SNP. 7 / 7
| 7
sparser
"Notably, we recapitulated the previously identified interaction between CACNA1C and a schizophrenia-associated SNP associated with decreased enhancer activity xref ."
27760116
sparser
"Taken together, the current findings provide evidence that the CACNA1C SNP rs1006737 is associated with increased amygdala activity across different diagnostic groups."
23437284
sparser
"These results support the notion that variations at the rs1006737 SNP in the CACNA1C gene are associated with Ca V 1.2 channel function in human excitatory neuron-like cells."
25403839
sparser
"Even though it is not consistently observed xref , xref , the majority of evidence suggests that the non-coding risk SNP rs1006737 is associated with enhanced CACNA1C expression and a gain of Ca V 1.2 function xref , xref , xref , suggesting deregulated Ca 2+ signaling in the affected population and a significantly increased probability of psychiatric diseases xref ."
29760952
sparser
"Although we observed nominal association of the bipolar disorder–associated CACNA1C SNP rs1006737 with global gray matter volume in 281 healthy individuals as described earlier in a sample of 77 subjects scanned at 1.5 T ( 8 ), this association was in a different direction, with the A allele associated with lower rather than the reported increased gray matter volume."
20638048
sparser
"Elevated cytosolic calcium levels, which may be associated with the CACNA1C risk SNP rs 1006737, represent a major upstream pathway that impairs mitochondrial function in BD xref ."
29760952
sparser
"In the exploratory analyses, we found genotype by diagnosis interactions between SNP rs4765913 of the CACNA1C gene and the sensory gating phenotype and between SNP rs13000464 of the GLS gene and P300 amplitude."
24339136
CACNA1C binds CFP and SNP. 1 / 1
| 1
sparser
"A recent demonstration that this SNP is associated with changes in PFC CACNA1C expression ( xref ) suggests that the neural effects of the SNP may be attributable to alterations in gene expression."
22085483
CACNA1C binds CXXC1 and SNP. 1 / 1
| 1
sparser
"A Dutch study found that CACNA1C CpG-SNP (rs1990322) was significantly associated with PTSD in traumatized police and children and may also interact with the FKBP5 antagonist FKBP4 [ xref ]."
30781888
PRKCB affects CACNA1C
8 |
PRKCB phosphorylates CACNA1C on S1674. 2 / 2
2 |
biopax:phosphositeplus
No evidence text available
biopax:phosphositeplus
No evidence text available
PRKCB phosphorylates CACNA1C on S533. 2 / 2
2 |
biopax:phosphositeplus
No evidence text available
biopax:phosphositeplus
No evidence text available
PRKCB phosphorylates CACNA1C on S528. 2 / 2
2 |
biopax:phosphositeplus
No evidence text available
biopax:phosphositeplus
No evidence text available
PRKCB phosphorylates CACNA1C on S1928. 2 / 2
2 |
biopax:phosphositeplus
No evidence text available
biopax:phosphositeplus
No evidence text available
CACNA1C affects QKI
| 5 3
CACNA1C binds QKI. 8 / 8
| 5 3
reach
"RNA immunoprecipitation (RIP) assay showed that QKI bound to CACNA1C mRNA, which was inhibited by tachypacing."
27660282
sparser
"Meanwhile, QKI overexpression in atrial myocytes restored the LPS-stimulated macrophage-induced electrical remodeling through enhanced binding of QKI to CACNA1C mRNA, which upregulated the expression of CACNA1C as well as I Ca-L . In contrast, QKI knockout inhibited CACNA1C expression."
27660282
sparser
"RNA immunoprecipitation (RIP) assay showed that QKI bound to CACNA1C mRNA, which was inhibited by tachypacing (Fig.  xref c, d)."
27660282
reach
"The main findings of the present study are : (1) increased pro inflammatory macrophages were found in the atria of AF patients, and HL-1 cell tachypacing induced pro inflammatory macrophage polarization; (2) pro inflammatory macrophage polarization played a major role in atrial electrical remodeling as evidenced by the increased incidence of AF in chronic LPS treatment in mice and canines, which was inhibited by the depletion of LPS stimulated macrophages; (3) the effect of LPS stimulated macrophages on electrical remodeling was mediated by IL-1beta secretion, which inhibited QKI expression in atrial myocytes; (4) QKI bound to CACNA1C mRNA and regulated the level of I Ca-L; and (5) the transcription factor Satb1 mediated QKI expression."
27660282
sparser
"The main findings of the present study are: (1) increased pro-inflammatory macrophages were found in the atria of AF patients, and HL-1 cell tachypacing induced pro-inflammatory macrophage polarization; (2) pro-inflammatory macrophage polarization played a major role in atrial electrical remodeling as evidenced by the increased incidence of AF in chronic LPS treatment in mice and canines, which was inhibited by the depletion of LPS-stimulated macrophages; (3) the effect of LPS-stimulated macrophages on electrical remodeling was mediated by IL-1β secretion, which inhibited QKI expression in atrial myocytes; (4) QKI bound to CACNA1C mRNA and regulated the level of I Ca-L ; and (5) the transcription factor Satb1 mediated QKI expression."
27660282
sparser
"Bioinformatics predicted that QKI could bind to CACNA1C mRNA, which was confirmed by RIP in our study."
27660282
reach
"Meanwhile, QKI overexpression in atrial myocytes restored the LPS stimulated macrophage induced electrical remodeling through enhanced binding of QKI to CACNA1C mRNA, which upregulated the expression of CACNA1C as well as I Ca-L."
27660282
sparser
"Recently, bioinformatics predicted that QKI could bind to CACNA1C mRNA, the α1C subunit of L-type calcium channel [ xref ], indicating a potential role for QKI in AF."
27660282
PRKCA affects CACNA1C
7 |
PRKCA phosphorylates CACNA1C on S1517. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCA phosphorylates CACNA1C on S1928. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCA phosphorylates CACNA1C on S1843. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCA phosphorylates CACNA1C on S1842. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCA phosphorylates CACNA1C on S1674. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCA phosphorylates CACNA1C on S533. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCA phosphorylates CACNA1C on S528. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
NR2F2 affects CACNA1C
| 4 3
CACNA1C binds CACNA1G and NR2F2. 4 / 4
| 4
sparser
"Converging evidence from ENCODE ChIP-seq data and chromatin immunoprecipitation (ChIP)-qPCR results indicate that COUP-TFII interacts with CACNA1G and CACNA1C and not NKX2.5 ( xref C), implicating a role for COUP-TFII in the direct regulation of CACNA1G and CACNA1C gene expression and the functional changes observed in atrial-like hiPSC-CM calcium handling."
29731429
sparser
"Additionally, the genomic locations where COUP-TFII binds to CACNA1G and CACNA1C in human atrial cells and CMs are sensitive to DNase treatment, indicating that they are accessible for transcriptional regulation and are also highly conserved across species ( xref A and S2B)."
29731429
sparser
"COUP-TFII binding to the promoters of CACNA1G ( xref H) and CACNA1C ( xref I) was significantly increased in RA versus CT hiPSCs."
29731429
sparser
"Collectively, these data indicate that COUP-TFII may bind to CACNA1G and CACNA1C , thereby regulating their gene expression and modulating calcium handling in atrial-like hiPSC-CMs."
29731429
CACNA1C binds NR2F2. 3 / 3
| 3
reach
"Converging evidence from ENCODE ChIP-seq data and chromatin immunoprecipitation (ChIP)-qPCR results indicate that COUP-TFII interacts with CACNA1G and CACNA1C and not NKX2.5 (XREF_SUPPLEMENTARY C), implicating a role for COUP-TFII in the direct regulation of CACNA1G and CACNA1C gene expression and the functional changes observed in atrial like hiPSC-CM calcium handling."
29731429
reach
"Additionally, the genomic locations where COUP-TFII binds to CACNA1G and CACNA1C in human atrial cells and CMs are sensitive to DNase treatment, indicating that they are accessible for transcriptional regulation and are also highly conserved across species (XREF_SUPPLEMENTARY A and S2B)."
29731429
reach
"Collectively, these data indicate that COUP-TFII may bind to CACNA1G and CACNA1C, thereby regulating their gene expression and modulating calcium handling in atrial like hiPSC-CMs."
29731429
CAMK2A affects CACNA1C
7 |
CAMK2A phosphorylates CACNA1C on S1570. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CAMK2A phosphorylates CACNA1C on S439. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CAMK2A phosphorylates CACNA1C on S1512. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CAMK2A phosphorylates CACNA1C on S1517. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CAMK2A phosphorylates CACNA1C on S1700. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CAMK2A phosphorylates CACNA1C on T1603. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CAMK2A phosphorylates CACNA1C on S1575. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CACNA1C affects NR2F2
| 4 3
CACNA1C binds CACNA1G and NR2F2. 4 / 4
| 4
sparser
"Converging evidence from ENCODE ChIP-seq data and chromatin immunoprecipitation (ChIP)-qPCR results indicate that COUP-TFII interacts with CACNA1G and CACNA1C and not NKX2.5 ( xref C), implicating a role for COUP-TFII in the direct regulation of CACNA1G and CACNA1C gene expression and the functional changes observed in atrial-like hiPSC-CM calcium handling."
29731429
sparser
"Additionally, the genomic locations where COUP-TFII binds to CACNA1G and CACNA1C in human atrial cells and CMs are sensitive to DNase treatment, indicating that they are accessible for transcriptional regulation and are also highly conserved across species ( xref A and S2B)."
29731429
sparser
"COUP-TFII binding to the promoters of CACNA1G ( xref H) and CACNA1C ( xref I) was significantly increased in RA versus CT hiPSCs."
29731429
sparser
"Collectively, these data indicate that COUP-TFII may bind to CACNA1G and CACNA1C , thereby regulating their gene expression and modulating calcium handling in atrial-like hiPSC-CMs."
29731429
CACNA1C binds NR2F2. 3 / 3
| 3
reach
"Converging evidence from ENCODE ChIP-seq data and chromatin immunoprecipitation (ChIP)-qPCR results indicate that COUP-TFII interacts with CACNA1G and CACNA1C and not NKX2.5 (XREF_SUPPLEMENTARY C), implicating a role for COUP-TFII in the direct regulation of CACNA1G and CACNA1C gene expression and the functional changes observed in atrial like hiPSC-CM calcium handling."
29731429
reach
"Additionally, the genomic locations where COUP-TFII binds to CACNA1G and CACNA1C in human atrial cells and CMs are sensitive to DNase treatment, indicating that they are accessible for transcriptional regulation and are also highly conserved across species (XREF_SUPPLEMENTARY A and S2B)."
29731429
reach
"Collectively, these data indicate that COUP-TFII may bind to CACNA1G and CACNA1C, thereby regulating their gene expression and modulating calcium handling in atrial like hiPSC-CMs."
29731429
TYMS affects CACNA1C
| 5 1
TYMS binds CACNA1C.
| 5
TYMS binds CACNA1C. 5 / 5
| 5
sparser
"Interestingly, recent identification of the CACNA1C-I116V mutation in a patient with LQTS offers a genetic enigma as it localizes to the identical residue as the CACNA1C-I1166T mutation which is associated with TS [37] ."
27390944
sparser
"Classically, TS is associated with mutations CACNA1C-G402S and G406R [5,6] ."
27390944
sparser
"In addition to disease with impaired cardiac repolarization, such as TS and LQTS, mutations in CACNA1C have been associated with other arrhythmias, such as Brugada syndrome and early repolarization syndrome [23] ."
27390944
sparser
"In contrast, heterozygous mutations in the CACNA1C gene (Cav1.2) are associated with a rare childhood multi-organ disorder called TS."
25633834
sparser
"Interestingly, recent identification of the CACNA1C-I116V mutation in a patient with LQTS offers a genetic enigma as it localizes to the identical residue as the CACNA1C-I1166T mutation which is associated with TS [ xref ]."
27390944
TYMS activates CACNA1C.
| 1
TYMS activates CACNA1C. 1 / 1
| 1
reach
"Novel Timothy Syndrome Mutation Leading to Increase in CACNA1C Window Current."
25260352
CACNA1C affects dopamine
| 6
CACNA1C activates dopamine. 6 / 6
| 6
reach
"Using rodent models of reduced Cacna1c function both globally and in specific brain regions, we show that Cacna1c modulates DA dependent stimulant induced locomotor activity and sensitization."
28186690
reach
"Further studies confirmed that Cacna1c mRNA and protein are downregulated by miR-153 mimics and upregulated by miR-153 inhibitors in insulin secreting freshly isolated mouse islets, in the insulin secreting mouse cell line MIN6 and in the dopamine secreting cell line PC12."
26141787
reach
"Overall, the data in this study indicate that Cacna1c modulates ML-DA dependent behavior and DA terminal dynamics, potentially through altered DA reuptake by VTA neurons."
28186690
reach
"Reduced levels of Cacna1c attenuate mesolimbic dopamine system function."
28186690
reach
"Therefore we show that Cacna1c modulates DA reuptake and that its function in the VTA is necessary for the development of stimulant induced sensitization."
28186690
reach
"Here, we further characterized the role of that decreased Cacna1c function on ML-DA system mediated behaviors and hypothesized that stimulant induced DA release and/or reuptake would be modulated by Cacna1c levels."
28186690
Egfp affects CACNA1C
| 5
CACNA1C binds egfp. 4 / 4
| 4
sparser
"When either the II–III loop fragment or the C2 domain of Munc13-1 was coexpressed, EGFP-CaV1.2 still formed clusters in the plasma membrane ( xref ), but its binding to granules (ΔF/S) was strongly reduced ( xref )."
28481223
sparser
"By dividing this value with the fluorescence of a single EGFP molecule (0.82 ± 0.01 × 10 6 cu/(W × s); xref ), we derived that, on average, 2.4 ± 0.4 EGFP-CaV1.2 molecules bound to each granule."
28481223
sparser
"As in human cells, responder granules were associated with stronger EGFP-CaV1.2 signals than were failures (ΔF/S = 0.10 ± 0.02 versus 0.006 ± 0.001, n = 91 granules, 18 cells; P = 0.0003) ( xref )."
28481223
sparser
"The average ΔF value in the experiments depicted in xref , is proportional to the copy number of EGFP-CaV1.2 molecules that are bound to the average granule site."
28481223
CACNA1C binds INS and egfp. 1 / 1
| 1
sparser
"Likewise, long-term culture with fatty acids, to emulate the diabetogenic action of a high-fat diet (HFD) ( xref ), decreased binding of EGFP-CaV1.2 to insulin granules ( xref )."
28481223
Calcium_channels affects CACNA1C
| 5
Calcium_channels binds CACNA1C. 2 / 2
| 2
sparser
"For example, vasoconstrictor drugs D00150 (angiotensin II) and D02014 (human type angiotensin II) were predicted to interact with L type calcium channel proteins (hsa:775, 776, 778, 779) that are the targets of antiarrhythmic drug D07520 (bepridil)."
22962489
sparser
"The literature shows that “CACNA1C” polymorphisms are associated with the efficacy of calcium channel blockers in the treatment of hypertension."
23934759
Calcium_channels binds CACNA1C and BP. 1 / 1
| 1
sparser
"Allelic variation at CACNA1C has been associated with BP response to calcium channel blockers ( xref , xref ), or even BP itself ( xref )."
22676942
Calcium_channels binds CACNA1A, CACNA1B, and CACNA1C. 1 / 1
| 1
sparser
"For instance, association of several voltage-dependent calcium channel genes such as CACNA1C and CACNA1B was reported in large-scale GWAS for BD. xref , xref A pathway analysis of GWAS data suggests enrichment of calcium channel-related pathways among the genes empirically associated with BD. xref Studies of peripheral blood cells have consistently demonstrated altered intracellular calcium signaling in BD. xref , xref Lithium, the first-line therapeutic drug for BD, modulates inositol-mediated pathways xref and thereby regulate calcium ion release from the endoplasmic reticulum. xref When we performed a GO enrichment analysis using DAVID xref , xref by integrating the data of de novo protein-altering mutations in our study, common single-nucleotide polymorphisms associated with BD in a large-scale GWAS xref and rare CNVs implicated in BD xref (total no. of unique input genes=229, see xref for details), ‘calcium signaling pathway (hsa04020)' was the only term significantly enriched after performing correction for multiple testing ( P corrected =6.4 × 10 −3 , Bonferroni correction; note that significant enrichment of ‘calcium signaling pathway (hsa04020)' after correction was not observed when we submitted candidate genes from each study)."
27217147
Calcium_channels binds CACNA1C, CACNA2D1, and Sudden Infant Death. 1 / 1
| 1
sparser
"It may even be higher, given that conventional genetic analysis may fail to uncover severe mutations [ xref – xref ] and that the determination of associations between SIDS and mutations in ion channel-related genes is still an emerging field, with several associations that have only recently been reported [ xref – xref ] and others that remain to be assessed, for example, a possible association between SIDS and mutations in the L-type calcium channel-related genes CACNA1C , CACNB2b, and CACNA2D1 , which have been associated with LQTS, BrS, and SQTS ( xref – xref )."
23304551
CACNA1C affects egfp
| 5
CACNA1C binds egfp. 4 / 4
| 4
sparser
"When either the II–III loop fragment or the C2 domain of Munc13-1 was coexpressed, EGFP-CaV1.2 still formed clusters in the plasma membrane ( xref ), but its binding to granules (ΔF/S) was strongly reduced ( xref )."
28481223
sparser
"By dividing this value with the fluorescence of a single EGFP molecule (0.82 ± 0.01 × 10 6 cu/(W × s); xref ), we derived that, on average, 2.4 ± 0.4 EGFP-CaV1.2 molecules bound to each granule."
28481223
sparser
"As in human cells, responder granules were associated with stronger EGFP-CaV1.2 signals than were failures (ΔF/S = 0.10 ± 0.02 versus 0.006 ± 0.001, n = 91 granules, 18 cells; P = 0.0003) ( xref )."
28481223
sparser
"The average ΔF value in the experiments depicted in xref , is proportional to the copy number of EGFP-CaV1.2 molecules that are bound to the average granule site."
28481223
CACNA1C binds INS and egfp. 1 / 1
| 1
sparser
"Likewise, long-term culture with fatty acids, to emulate the diabetogenic action of a high-fat diet (HFD) ( xref ), decreased binding of EGFP-CaV1.2 to insulin granules ( xref )."
28481223
CACNA1C affects Calcium_channels
| 5
Calcium_channels binds CACNA1C. 2 / 2
| 2
sparser
"For example, vasoconstrictor drugs D00150 (angiotensin II) and D02014 (human type angiotensin II) were predicted to interact with L type calcium channel proteins (hsa:775, 776, 778, 779) that are the targets of antiarrhythmic drug D07520 (bepridil)."
22962489
sparser
"The literature shows that “CACNA1C” polymorphisms are associated with the efficacy of calcium channel blockers in the treatment of hypertension."
23934759
Calcium_channels binds CACNA1C and BP. 1 / 1
| 1
sparser
"Allelic variation at CACNA1C has been associated with BP response to calcium channel blockers ( xref , xref ), or even BP itself ( xref )."
22676942
Calcium_channels binds CACNA1A, CACNA1B, and CACNA1C. 1 / 1
| 1
sparser
"For instance, association of several voltage-dependent calcium channel genes such as CACNA1C and CACNA1B was reported in large-scale GWAS for BD. xref , xref A pathway analysis of GWAS data suggests enrichment of calcium channel-related pathways among the genes empirically associated with BD. xref Studies of peripheral blood cells have consistently demonstrated altered intracellular calcium signaling in BD. xref , xref Lithium, the first-line therapeutic drug for BD, modulates inositol-mediated pathways xref and thereby regulate calcium ion release from the endoplasmic reticulum. xref When we performed a GO enrichment analysis using DAVID xref , xref by integrating the data of de novo protein-altering mutations in our study, common single-nucleotide polymorphisms associated with BD in a large-scale GWAS xref and rare CNVs implicated in BD xref (total no. of unique input genes=229, see xref for details), ‘calcium signaling pathway (hsa04020)' was the only term significantly enriched after performing correction for multiple testing ( P corrected =6.4 × 10 −3 , Bonferroni correction; note that significant enrichment of ‘calcium signaling pathway (hsa04020)' after correction was not observed when we submitted candidate genes from each study)."
27217147
Calcium_channels binds CACNA1C, CACNA2D1, and Sudden Infant Death. 1 / 1
| 1
sparser
"It may even be higher, given that conventional genetic analysis may fail to uncover severe mutations [ xref – xref ] and that the determination of associations between SIDS and mutations in ion channel-related genes is still an emerging field, with several associations that have only recently been reported [ xref – xref ] and others that remain to be assessed, for example, a possible association between SIDS and mutations in the L-type calcium channel-related genes CACNA1C , CACNB2b, and CACNA2D1 , which have been associated with LQTS, BrS, and SQTS ( xref – xref )."
23304551
MiR-135b affects CACNA1C
| 4
MiR-135b activates CACNA1C.
| 3
MiR-135b activates CACNA1C. 3 / 3
| 3
reach
"Overexpression of miR-135b attenuates pathological cardiac hypertrophy by targeting CACNA1C."
30037628
reach
"The overexpression of miR-135b attenuated cardiac hypertrophy by targeting CACNA1C."
30037628
reach
"Here, we hypothesize that the overexpression of miR-135b can attenuate hypertrophy by targeting CACNA1C."
30037628
MiR-135b binds CACNA1C.
| 1
CACNA1C binds miR-135b. 1 / 1
| 1
reach
"Luciferase reporter assays were used to testify the binding of miR-135b to the CACNA1C 3 ' UTR."
30037628
PRKG1 affects CACNA1C
4 |
PRKG1 phosphorylates CACNA1C on S1928. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKG1 phosphorylates CACNA1C on S1928. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKG1 phosphorylates CACNA1C on S528. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKG1 phosphorylates CACNA1C on S533. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKD1 affects CACNA1C
2 2 |
PRKD1 phosphorylates CACNA1C.
2 1 |
PRKD1 phosphorylates CACNA1C on S1981. 2 / 2
1 1 |
signor
"Both the expression of a dominant-negative mutant of pkd and the mutation of serine 1884 but not serine 1930, putative targets of pkd, strongly reduced l-type calcium currents and single channel activity without affecting the channel's expression at the plasma membrane. Our results suggest that serine 1884 is essential for the regulation of hcav1.2 by pkd."
22100296
biopax:phosphositeplus
No evidence text available
PRKD1 phosphorylates CACNA1C on S1928. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKD1 activates CACNA1C.
1 |
PRKD1 activates CACNA1C. 1 / 1
1 |
signor
"Both the expression of a dominant-negative mutant of pkd and the mutation of serine 1884 but not serine 1930, putative targets of pkd, strongly reduced l-type calcium currents and single channel activity without affecting the channel's expression at the plasma membrane. Our results suggest that serine 1884 is essential for the regulation of hcav1.2 by pkd."
22100296
PRKCZ affects CACNA1C
4 |
PRKCZ phosphorylates CACNA1C on S1928. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCZ phosphorylates CACNA1C on S1674. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCZ phosphorylates CACNA1C on S533. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCZ phosphorylates CACNA1C on S528. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCQ affects CACNA1C
4 |
PRKCQ phosphorylates CACNA1C on S1674. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCQ phosphorylates CACNA1C on S528. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCQ phosphorylates CACNA1C on S1928. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCQ phosphorylates CACNA1C on S533. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCG affects CACNA1C
4 |
PRKCG phosphorylates CACNA1C on S1674. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCG phosphorylates CACNA1C on S533. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCG phosphorylates CACNA1C on S1928. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCG phosphorylates CACNA1C on S528. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCD affects CACNA1C
4 |
PRKCD phosphorylates CACNA1C on S1674. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCD phosphorylates CACNA1C on S1928. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCD phosphorylates CACNA1C on S533. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCD phosphorylates CACNA1C on S528. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PCLO affects CACNA1C
| 4
PCLO binds CACNA1C. 4 / 4
| 4
sparser
"When testing for a gene–gene interaction using a random effects two-way ANOVA model of the novelty encoding contrasts (subsequently recognized novel scenes compared with the master images), we could replicate the complex interaction of CACNA1C rs1006737 and PCLO rs2522833 observed in the first two experiments, with carriers of either no or both high-risk alleles showing higher CG25 activation relative to carriers of either rs1006737 A or rs2522833 C alleles, but not both (F 1,105 =14.62; P =0.039, FWE-corrected for CG25 ROI volume; xref )."
24643163
sparser
"In all the three experiments, we could observe a complex interaction of PCLO and CACNA1C genotypes in the subgenual cingulate cortex."
24643163
sparser
"We observed a complex gene–gene interaction of CACNA1C rs1006737 and PCLO rs2522833 in CG25, with participants homozygous for the low-risk allele of both SNPs and carriers of both high-risk alleles showing higher CG25 activation during self-reference when compared with carriers of only one high-risk allele (either CACNA1C rs1006737 A or PCLO rs2522833 C, but not both; F 1,71 =13.50; P =0.034, FWE-corrected for CG25 ROI volume; see xref )."
24643163
sparser
"Summarizing the results of the three experiments, we could observe a gene–gene interaction between CACNA1C rs1006737 and PCLO rs2522833 in CG25 where carriers of no risk allele and carriers of both risk alleles exhibited higher activation relative to carriers of only one risk variant during episodic encoding relative to baseline."
24643163
CACNA1C affects CACNA1G, and NR2F2
| 4
CACNA1C binds CACNA1G and NR2F2. 4 / 4
| 4
sparser
"Converging evidence from ENCODE ChIP-seq data and chromatin immunoprecipitation (ChIP)-qPCR results indicate that COUP-TFII interacts with CACNA1G and CACNA1C and not NKX2.5 ( xref C), implicating a role for COUP-TFII in the direct regulation of CACNA1G and CACNA1C gene expression and the functional changes observed in atrial-like hiPSC-CM calcium handling."
29731429
sparser
"Additionally, the genomic locations where COUP-TFII binds to CACNA1G and CACNA1C in human atrial cells and CMs are sensitive to DNase treatment, indicating that they are accessible for transcriptional regulation and are also highly conserved across species ( xref A and S2B)."
29731429
sparser
"COUP-TFII binding to the promoters of CACNA1G ( xref H) and CACNA1C ( xref I) was significantly increased in RA versus CT hiPSCs."
29731429
sparser
"Collectively, these data indicate that COUP-TFII may bind to CACNA1G and CACNA1C , thereby regulating their gene expression and modulating calcium handling in atrial-like hiPSC-CMs."
29731429
CACNA1C affects CABP1
3 1 |
CABP1 binds CACNA1C. 4 / 4
3 1 |
biogrid
No evidence text available
15140941
biogrid
No evidence text available
15140941
biogrid
No evidence text available
15140941
hprd
No evidence text available
15140941
CACNA1C affects BP
| 4
CACNA1C binds BP. 3 / 3
| 3
sparser
"We performed a family-based association study to determine whether CACNA1C is associated with BP in the Latino population.   This study included 913 individuals from 215 Latino pedigrees recruited from the USA, Mexico, Guatemala, and Costa Rica."
23437964
sparser
"These results provide additional evidence that CACNA1C is associated with BP and provides the first evidence that variations in this gene might play a role in the pathogenesis of this disorder in the Latino population."
23437964
sparser
"None of the other intronic CACNA1C SNPs were associated with BP."
24716743
Calcium_channels binds CACNA1C and BP. 1 / 1
| 1
sparser
"Allelic variation at CACNA1C has been associated with BP response to calcium channel blockers ( xref , xref ), or even BP itself ( xref )."
22676942
CABP1 affects CACNA1C
3 1 |
CABP1 binds CACNA1C. 4 / 4
3 1 |
biogrid
No evidence text available
15140941
biogrid
No evidence text available
15140941
biogrid
No evidence text available
15140941
hprd
No evidence text available
15140941
BP affects CACNA1C
| 4
CACNA1C binds BP. 3 / 3
| 3
sparser
"We performed a family-based association study to determine whether CACNA1C is associated with BP in the Latino population.   This study included 913 individuals from 215 Latino pedigrees recruited from the USA, Mexico, Guatemala, and Costa Rica."
23437964
sparser
"These results provide additional evidence that CACNA1C is associated with BP and provides the first evidence that variations in this gene might play a role in the pathogenesis of this disorder in the Latino population."
23437964
sparser
"None of the other intronic CACNA1C SNPs were associated with BP."
24716743
Calcium_channels binds CACNA1C and BP. 1 / 1
| 1
sparser
"Allelic variation at CACNA1C has been associated with BP response to calcium channel blockers ( xref , xref ), or even BP itself ( xref )."
22676942
Ryanodine receptor affects CACNA1C
| 3
CACNA1C binds ryanodine receptor. 2 / 2
| 2
sparser
"Using calcium imaging and pharmacological inhibitors, we found that ryanodine receptors are selectively associated with L type VGCCs but likely not through a physical linkage."
23826376
sparser
"Since L type calcium channels are expressed in mammalian taste cells xref , xref , xref and are known to interact with ryanodine receptors in skeletal muscle as well as in the central nervous system xref , xref , xref , we next tested the hypothesis that ryanodine receptors interact with L type calcium channels in taste cells."
23826376
Voltage_gated_ion_channels binds CACNA1C and ryanodine receptor. 1 / 1
| 1
sparser
"These data indicate that ryanodine receptors may be interacting with the L type voltage gated calcium channels."
23826376
Pyraclofos affects CACNA1C
| 1 2
Pyraclofos inhibits CACNA1C.
| 1
Pyraclofos inhibits CACNA1C. 1 / 1
| 1
reach
"[XREF_BIBR] Timothy syndrome (TS) is an extremely rare multisystem form of LQTS caused by gain-of-function mutations that impair the voltage dependent inactivation of the CACNA1C encoded Cav1.2 channel resulting in an increased L-type Ca 2+ current (I Ca, L) during the plateau phase of the cardiac action potential (XREF_FIG) leading to a complex phenotype that includes variable degrees of autism spectrum disorder, syndactyly, and severe cardiac arrhythmias."
24093767
Pyraclofos increases the amount of CACNA1C.
| 1
Pyraclofos increases the amount of CACNA1C. 1 / 1
| 1
reach
"Recently, the alpha1-C subunit of the L-type voltage gated calcium channel (CACNA1C) gene has been described as a risk gene for BD and its Met allele found to increase CACNA1C mRNA expression."
22464935
Pyraclofos activates CACNA1C.
| 1
Pyraclofos activates CACNA1C. 1 / 1
| 1
sparser
"An increase in the intravascular pressure can depolarize smooth muscle cell sarcolemma and promote opening of voltage-activated CaV1.2 channels [19] ."
26643253
Lipopolysaccharide affects CACNA1C
| 3
Lipopolysaccharide increases the amount of CACNA1C.
| 1
Lipopolysaccharide increases the amount of CACNA1C. 1 / 1
| 1
reach
"Co-culture with LPS stimulated macrophage medium inhibited CACNA1C expression in atrial myocytes, which was restored by IL-1beta knockout in macrophages using the CRISPR and Cas9 system, suggesting that repression of CACNA1C expression by LPS stimulated macrophage medium was mediated by IL-1beta."
27660282
Lipopolysaccharide decreases the amount of CACNA1C.
| 1
Lipopolysaccharide decreases the amount of CACNA1C. 1 / 1
| 1
reach
"Co-culture with LPS stimulated macrophage medium inhibited CACNA1C expression in atrial myocytes, which was restored by IL-1beta knockout in macrophages using the CRISPR and Cas9 system, suggesting that repression of CACNA1C expression by LPS stimulated macrophage medium was mediated by IL-1beta."
27660282
Lipopolysaccharide activates CACNA1C.
| 1
Lipopolysaccharide activates CACNA1C. 1 / 1
| 1
reach
"IL-1beta knockout in macrophages restored the LPS stimulated macrophage induced inhibition of QKI and CACNA1C (alpha1C subunit of L-type calcium channel) in atrial myocytes."
27660282
RYR affects CACNA1C
| 3
CACNA1C binds RYR. 3 / 3
| 3
sparser
"We concluded that despite the presence of multiple voltage-gated channels in taste cells, RyRs preferentially interact with the L type calcium channels in Type III taste cells."
23826376
sparser
"There is also evidence of a physical interaction between RyRs and L type VGCCs in multiple types of neurons including hypothalamic magnocellular neurons, dorsal column axons and hippocampal pyramidal neurons xref – xref , xref ."
23826376
sparser
"Nature of Interaction between RyRs and L type Calcium Channels."
23826376
PRKCE affects CACNA1C
3 |
PRKCE phosphorylates CACNA1C on S528. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCE phosphorylates CACNA1C on S533. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
PRKCE phosphorylates CACNA1C on S1928. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
MVD1 affects CACNA1C
| 3
CACNA1C binds MVD1. 3 / 3
| 3
sparser
"In the present study, we tested the association of CACNA1C with MDD and BD in Han Chinese."
23680436
sparser
"The interactions between MDD and CACNA1C single nucleotide polymorphism rs11832738 were determined using two-way factorial analysis of covariance, with age, sex, education, and head motion as covariates."
32161558
sparser
"A previous study by Green et al. (2009) described an association of the CACNA1C polymorphism rs1006737 with MDD, when testing this polymorphism exclusively."
22647524
CACNA1C affects ryanodine receptor
| 3
CACNA1C binds ryanodine receptor. 2 / 2
| 2
sparser
"Using calcium imaging and pharmacological inhibitors, we found that ryanodine receptors are selectively associated with L type VGCCs but likely not through a physical linkage."
23826376
sparser
"Since L type calcium channels are expressed in mammalian taste cells xref , xref , xref and are known to interact with ryanodine receptors in skeletal muscle as well as in the central nervous system xref , xref , xref , we next tested the hypothesis that ryanodine receptors interact with L type calcium channels in taste cells."
23826376
Voltage_gated_ion_channels binds CACNA1C and ryanodine receptor. 1 / 1
| 1
sparser
"These data indicate that ryanodine receptors may be interacting with the L type voltage gated calcium channels."
23826376
CACNA1C affects miR-29a-3p
| 3
CACNA1C activates miR-29a-3p. 3 / 3
| 3
reach
"The results confirmed that CACNA1C was a validated target of miR-29a-3p."
27341015
reach
"CACNA1C was a target of miR-29a-3p."
27341015
reach
"Furthermore, we performed luciferase assay to confirm that CACNA1C was a validated target of miR-29a-3p."
27341015
CACNA1C affects lithium(1+)
| 3
CACNA1C activates lithium(1+). 3 / 3
| 3
reach
"Our main finding is that CACNA1C modulates the cellular rhythm amplitude response to lithium, providing a specific link between LTCCs and circadian rhythms in the context of BD and lithium."
26476274
reach
"Loss of CACNA1C had no effect on period by itself but attenuated the period lengthening effects of lithium."
26476274
reach
"Loss of CACNA1C had no effect on period by itself but attenuated the period lengthening effects of lithium (XREF_FIG)."
26476274
CACNA1C affects cell death
| 3
CACNA1C activates cell death.
| 2
CACNA1C activates cell death. 2 / 2
| 2
reach
"The aberrant splicing event in CaMKII-delta and Cacna1c can impact calcium homeostasis, and increase the risk of sudden death in RBM20 mutant species."
29304022
reach
"Knockdown of Cacna1c mediated protection against glutamate induced cell death."
29760952
CACNA1C inhibits cell death.
| 1
CACNA1C inhibits cell death. 1 / 1
| 1
reach
"For example, deletion of Cacna1c, which encodes the Cav1.2 subunit of L-type calcium channels, causes increased cell death of hippocampal neurons in knockout mice and mice harboring forebrain specific conditional knockout of Cacna1c display unusually high anxiety like behavior."
28751711
CACNA1C affects RYR
| 3
CACNA1C binds RYR. 3 / 3
| 3
sparser
"We concluded that despite the presence of multiple voltage-gated channels in taste cells, RyRs preferentially interact with the L type calcium channels in Type III taste cells."
23826376
sparser
"There is also evidence of a physical interaction between RyRs and L type VGCCs in multiple types of neurons including hypothalamic magnocellular neurons, dorsal column axons and hippocampal pyramidal neurons xref – xref , xref ."
23826376
sparser
"Nature of Interaction between RyRs and L type Calcium Channels."
23826376
CACNA1C affects PRKACA
3 |
CACNA1C binds PRKACA. 3 / 3
3 |
hprd
No evidence text available
9247274
hprd
No evidence text available
8612821
hprd
No evidence text available
8664319
CACNA1C affects MVD1
| 3
CACNA1C binds MVD1. 3 / 3
| 3
sparser
"In the present study, we tested the association of CACNA1C with MDD and BD in Han Chinese."
23680436
sparser
"The interactions between MDD and CACNA1C single nucleotide polymorphism rs11832738 were determined using two-way factorial analysis of covariance, with age, sex, education, and head motion as covariates."
32161558
sparser
"A previous study by Green et al. (2009) described an association of the CACNA1C polymorphism rs1006737 with MDD, when testing this polymorphism exclusively."
22647524
CACNA1C affects LQT8
| 3
CACNA1C activates LQT8. 2 / 2
| 2
reach
"LQT8 and Timothy syndrome are caused by mutation in the CACNA1C gene encoding the L-type Ca 2+ channel."
23015789
reach
"LQT8 is caused by the mutations in CACNA1C gene, which encodes an alpha-1 subunit of a voltage dependent calcium channel (L-type cardiac calcium channel) XREF_BIBR."
28616568
Mutated CACNA1C activates LQT8. 1 / 1
| 1
reach
"Similarly, CACNA1C mutations cause LQT8 in Timothy syndrome."
27242528
CACNA1C affects BRS3
| 1 2
CACNA1C activates BRS3.
| 2
CACNA1C activates BRS3. 2 / 2
| 2
reach
"Thus, BrS3, caused by the mutation in CACNA1C, such as p.A39V, p.G490R, p.E1829 _ Q1833 duplication, and p.E850 deletion, also known as SQT4; and BrS4, caused by CACNB2 p.S481L mutation, is also known as SQT5 [98]."
30027834
reach
"Mutations in CACNA1C, CACNB2 and CACNA2D1 can cause BrS3, BrS4 and BrS9, respectively [96,97]."
30027834
CACNA1C binds BRS3.
| 1
BRS3 binds CACNA1C. 1 / 1
| 1
sparser
"BrS3 is associated with mutations in CACNA1C (see Table xref )."
23874304
AGT affects CACNA1C
| 3
AGT activates CACNA1C.
| 2
AGT activates CACNA1C. 2 / 2
| 2
reach
"YY1 induced upregulation of lncRNA KCNQ1OT1 regulates angiotensin II induced atrial fibrillation by modulating miR-384b and CACNA1C axis."
30241939
reach
"In conclusion, the present study revealed that YY1 induced upregulation of lncRNA KCNQ1OT1 regulates angiotensin II induced atrial fibrillation by regulating miR-384 and CACNA1C axis."
30241939
AGT increases the amount of CACNA1C.
| 1
AGT increases the amount of CACNA1C. 1 / 1
| 1
reach
"34 Angiotensin II was shown to upregulate the expression and activity of CACNA1C in cultured arteries."
26553695
ADRB1 affects ADRB2, AGT, CACNA1A, CACNA1C, and SLC12A3
| 3
SLC12A3 binds CACNA1A, CACNA1C, ADRB1, ADRB2, and AGT. 3 / 3
| 3
sparser
"We find nominal evidence of association of ADRB1 , ADRB2 , AGT , CACNA1A , CACNA1C , and SLC12A3 polymorphisms with one or more BP traits in the CHARGE GWA meta-analysis."
21444836
sparser
"Nominal evidence of association of ADRB1, ADRB2, AGT, CACNA1A, CACNA1C , and SLC12A3 polymorphisms with one or more BP traits was observed."
21953487
sparser
"We find nominal evidence of association of ADRB1, ADRB2, AGT, CACNA1A, CACNA1C, and SLC12A3 polymorphisms with 1 or more BP traits in the Cohorts for Heart and Aging Research in Genomic Epidemiology genome-wide association meta-analysis."
21444836
Trauma affects CACNA1C
| 2
CACNA1C binds trauma. 2 / 2
| 2
isi
"The role of CACNA1C gene and childhood trauma interaction on bipolar disorder."
32169562
isi
"The role of CACNA1C gene and childhood trauma interaction on bipolar disorder."
32169562
Sulforaphane affects CACNA1C
| 2
Sulforaphane inhibits CACNA1C.
| 1
Sulforaphane inhibits CACNA1C. 1 / 1
| 1
reach
"Intra-peritoneal administration of sulforaphane significantly reversed the suppression of Nrf2, oxidative damage in the promoter of Cacna1c, and suppression of Cacna1c on day 7 of inflammation."
21745450
Sulforaphane activates CACNA1C.
| 1
Sulforaphane activates CACNA1C. 1 / 1
| 1
reach
"Intra-peritoneal administration of sulforaphane significantly reversed the suppression of Nrf2, oxidative damage in the promoter of Cacna1c, and suppression of Cacna1c on day 7 of inflammation."
21745450
Malonaldehyde affects CACNA1C
| 2
Malonaldehyde binds CACNA1C. 2 / 2
| 2
reach
"Our study provides support for positive association between CACNA1C and MDD; however, the current data suggest the necessity of replication analyses in a larger-scale sample."
27260792
reach
"The interactions between MDD and CACNA1C single nucleotide polymorphism rs11832738 were determined using two-way factorial analysis of covariance, with age, sex, education, and head motion as covariates."
32161558
Dopamine affects CACNA1C
| 2
Dopamine increases the amount of CACNA1C. 2 / 2
| 2
reach
"Our data also shows that the dopamine D1 receptor signaling pathway may modulate CACNA1C expression via CREB and that this is dependent upon the presence of METH."
25807982
reach
"However, treatment with SKF 82958, a full dopamine D1 receptor agonist, did not increase CACNA1C expression, as expression levels remained comparable to untreated control cells."
25807982
Calcium(2+) affects CACNA1C
| 1 2
Calcium(2+) activates CACNA1C. 2 / 2
| 1 2
reach
"The expression of functionally different splice isoforms of Ca V 1.2 and Ca V 1.3 in different tissues enables Cacna1c and Cacna1d genes to support a wider range of calcium dependent cellular functions [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
25966698
reach
"Timothy Syndrome, a disorder encompassing multiple dysfunctions including autistic phenotypes, can be caused by a mutation in Ca V 1.2 (CACNA1C), which increases the open times of VSCCs."
19376067
Voltage_gated_ion_channels affects CACNA1C
| 2
Voltage_gated_ion_channels binds CACNA1C. 1 / 1
| 1
sparser
"20 Interestingly, the CACNA1C gene, which encodes the L-type voltage-gated Ca 2+ channel alpha 1c subunit, has also been associated with cardiac arrhythmias."
30170228
Voltage_gated_ion_channels binds CACNA1C and ryanodine receptor. 1 / 1
| 1
sparser
"These data indicate that ryanodine receptors may be interacting with the L type voltage gated calcium channels."
23826376
STIM1 affects CACNA1C
| 2 1 1
STIM1 binds CACNA1C. 2 / 2
| 2 1 1
reach
"XREF_BIBR - XREF_BIBR Due to its proximity, Arg1906Gln could alter STIM1 binding to CACNA1C, preventing the internalization of the channel, leading to an increased number of channels on the membrane, and a gain-of-function in Ca v 1.2 currents."
23677916
sparser
"STIM1-CaV1.2 interaction via the SOAR domain was demonstrated by co-immunoprecipitation of STIM1, while high-resolution imaging of ER-PM junctions revealed co-localization of STIM1/SOAR and CaV1.2 upon store depletion."
23568369
SRI affects CACNA1C
1 1 |
SRI binds CACNA1C. 2 / 2
1 1 |
biogrid
No evidence text available
9668070
hprd
No evidence text available
9668070
PKA affects CACNA1C
| 1 1 1
PKA phosphorylates CACNA1C.
| 1 1
PKA phosphorylates CACNA1C. 1 / 1
| 1 1
sparser
"Some of the cardinal debated issues include details of specific subunits and residues in CaV1.2 phosphorylated by PKA, the nature, extent, and role of post-translational processing of CaV1.2, and the role of auxiliary proteins (such as A kinase anchoring proteins) involved in PKA regulation."
23948586
PKA activates CACNA1C.
| 1
PKA activates CACNA1C. 1 / 1
| 1
reach
"The action of GPBAR1 included PKA dependent activation of L-type Ca 2+ currents, which have been closely linked to vesicular exocytosis in pancreatic beta-cells XREF_BIBR, and would likely be mimicked by other G alphas -coupled receptors."
29167062
NFAT5 affects CACNA1C
| 2
NFAT5 increases the amount of CACNA1C. 2 / 2
| 2
reach
"Nfat5 knockdown suppresses Cacna1c expression, decreases L-type calcium current, and results in non beating ventricle."
27368804
reach
"Nfat5 activates the transcription of Cacna1c."
27368804
MIR137 affects CACNA1C
| 2
CACNA1C binds MIR137. 2 / 2
| 2
reach
"Investigations for potential epistatic interactions between MIR137 and CACNA1C would be desirable, and further functional exploration of the interactions will facilitate our elucidation of the pathogenesis of SCZ and finding promising new approaches for the treatment of this disorder.Our work provides further evidence for the association with SCZ of MIR137 and its target gene of the primary transcript miR-137, CACNA1C."
24275578
reach
"Fortunately, the interaction between MIR137 and CACNA1C has been confirmed, and much is known about the physiology of CACNA1C signaling that will facilitate explanations for our observations."
24275578
METH affects CACNA1C
| 2
METH increases the amount of CACNA1C.
| 1
METH increases the amount of CACNA1C. 1 / 1
| 1
reach
"METH induces CACNA1C gene expression and protein accumulation in the heart, with reduced DNA methylation observed in the CACNA1C promoter following METH treatment that correlated to gene expression changes."
26307267
METH activates CACNA1C.
| 1
METH activates CACNA1C. 1 / 1
| 1
reach
"Both induce changes in DNA methylation, though only CACNA1C is upregulated by METH."
26307267
INS affects CACNA1C
| 1 1
INS inhibits CACNA1C.
| 1
INS inhibits CACNA1C. 1 / 1
| 1
reach
"Further studies confirmed that Cacna1c mRNA and protein are downregulated by miR-153 mimics and upregulated by miR-153 inhibitors in insulin secreting freshly isolated mouse islets, in the insulin secreting mouse cell line MIN6 and in the dopamine secreting cell line PC12."
26141787
INS binds CACNA1C.
| 1
CACNA1C binds INS and egfp. 1 / 1
| 1
sparser
"Likewise, long-term culture with fatty acids, to emulate the diabetogenic action of a high-fat diet (HFD) ( xref ), decreased binding of EGFP-CaV1.2 to insulin granules ( xref )."
28481223
CREB1 affects CACNA1C
| 2
CREB1 increases the amount of CACNA1C.
| 1
Modified CREB1 increases the amount of CACNA1C. 1 / 1
| 1
reach
"In contrast, a combination of enhanced CREB1 expression and activation of D1DR by its agonist is not sufficient to upregulate CACNA1C expression, suggesting that additional factors other than CREB1 are necessary to increase CACNA1C expression."
25807982
CREB1 binds CACNA1C.
| 1
CACNA1C binds CREB1. 1 / 1
| 1
reach
"Finally, we did not detect an association between CACNA1c, CREB1, or GRIA3, and sleep behaviors."
26739645
CFP affects CACNA1C
| 1 1
CFP inhibits CACNA1C.
| 1
CFP inhibits CACNA1C. 1 / 1
| 1
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR We report that global haploinsufficiency, forebrain specific elimination and prefrontal cortex (PFC)-specific knockdown of cacna1c all increase anxiety related behavior in mice, a prominent component of the forms of neuropsychiatric disease in which aberrations in CACNA1C have been implicated, without affecting compulsive behavior."
22665262
CFP binds CACNA1C.
| 1
CACNA1C binds CFP and SNP. 1 / 1
| 1
sparser
"A recent demonstration that this SNP is associated with changes in PFC CACNA1C expression ( xref ) suggests that the neural effects of the SNP may be attributable to alterations in gene expression."
22085483
CALM affects CACNA1C
| 5 1 1
CALM phosphorylates CACNA1C.
| 1
CALM phosphorylates CACNA1C. 1 / 1
| 1
reach
"cAMP kinase, cGMP kinase, protein kinase C, calmodulin kinase II and casein kinase II phosphorylated the 165-kDa and the 55-kDa proteins of the purified CaCB receptor."
2850184
CALM binds CACNA1C.
| 5 1
CALM binds CACNA1C. 1 / 1
| 5 1
sparser
"Ca 2+ -CaM and CaV1.2 interaction is a dual-direction regulation on L-type calcium channel, including Ca 2+ -dependent facilitation (CDF) and Ca 2+ -dependent inactivation (CDI)."
26544729
CACNA1C affects trauma
| 2
CACNA1C binds trauma. 2 / 2
| 2
isi
"The role of CACNA1C gene and childhood trauma interaction on bipolar disorder."
32169562
isi
"The role of CACNA1C gene and childhood trauma interaction on bipolar disorder."
32169562
CACNA1C affects sleep
| 2
CACNA1C activates sleep. 2 / 2
| 2
reach
"In an experimental model, Cacna1c has been found to modulate the electrophysiological architecture of sleep."
28792954
reach
"Cacna1c has been found to modulate the electrophysiological architecture of sleep in mice."
28792954
CACNA1C affects malonaldehyde
| 2
Malonaldehyde binds CACNA1C. 2 / 2
| 2
reach
"Our study provides support for positive association between CACNA1C and MDD; however, the current data suggest the necessity of replication analyses in a larger-scale sample."
27260792
reach
"The interactions between MDD and CACNA1C single nucleotide polymorphism rs11832738 were determined using two-way factorial analysis of covariance, with age, sex, education, and head motion as covariates."
32161558
CACNA1C affects cellular component biogenesis
| 2
CACNA1C activates cellular component biogenesis. 2 / 2
| 2
reach
"Our results indicate that Cacna1c downregulation stimulates mitochondrial biogenesis under oxidative stress without affecting mitophagic processes, thereby promoting the turnover of mitochondria and preventing the accumulation of dysfunctional mitochondria in HT22 cells."
29760952
reach
"In the employed paradigm of oxidative glutamate toxicity, Cacna1c depletion also protected against detrimental mitochondrial fission and stimulated mitochondrial biogenesis without affecting mitophagy, thus promoting the turnover of mitochondria and preventing the accumulation of dysfunctional mitochondria in neuronal HT22 cells."
29844355
CACNA1C affects Voltage_gated_ion_channels
| 2
Voltage_gated_ion_channels binds CACNA1C. 1 / 1
| 1
sparser
"20 Interestingly, the CACNA1C gene, which encodes the L-type voltage-gated Ca 2+ channel alpha 1c subunit, has also been associated with cardiac arrhythmias."
30170228
Voltage_gated_ion_channels binds CACNA1C and ryanodine receptor. 1 / 1
| 1
sparser
"These data indicate that ryanodine receptors may be interacting with the L type voltage gated calcium channels."
23826376
CACNA1C affects STIM1
| 2 1 1
STIM1 binds CACNA1C. 2 / 2
| 2 1 1
reach
"XREF_BIBR - XREF_BIBR Due to its proximity, Arg1906Gln could alter STIM1 binding to CACNA1C, preventing the internalization of the channel, leading to an increased number of channels on the membrane, and a gain-of-function in Ca v 1.2 currents."
23677916
sparser
"STIM1-CaV1.2 interaction via the SOAR domain was demonstrated by co-immunoprecipitation of STIM1, while high-resolution imaging of ER-PM junctions revealed co-localization of STIM1/SOAR and CaV1.2 upon store depletion."
23568369
CACNA1C affects SRI
1 1 |
SRI binds CACNA1C. 2 / 2
1 1 |
biogrid
No evidence text available
9668070
hprd
No evidence text available
9668070
CACNA1C affects RBM20
| 2
CACNA1C activates RBM20. 2 / 2
| 2
reach
"Genome editing studies show that TTN pre-mRNA, the main RBM20 regulated transcript in the heart, nucleates RBM20 foci that drive spatial proximity between the TTN locus and other inter-chromosomal RBM20 targets such as CACNA1C and CAMK2D."
30948719
reach
"On the other hand, splicing alterations in other RBM20 targets such as CamkIIdelta, RyR2, and Cacna1c might affect Ca 2+ homeostasis."
30050558
CACNA1C affects MIR137
| 2
CACNA1C binds MIR137. 2 / 2
| 2
reach
"Investigations for potential epistatic interactions between MIR137 and CACNA1C would be desirable, and further functional exploration of the interactions will facilitate our elucidation of the pathogenesis of SCZ and finding promising new approaches for the treatment of this disorder.Our work provides further evidence for the association with SCZ of MIR137 and its target gene of the primary transcript miR-137, CACNA1C."
24275578
reach
"Fortunately, the interaction between MIR137 and CACNA1C has been confirmed, and much is known about the physiology of CACNA1C signaling that will facilitate explanations for our observations."
24275578
CACNA1C affects MAPT
| 2
CACNA1C dephosphorylates MAPT.
| 1
CACNA1C leads to the dephosphorylation of MAPT. 1 / 1
| 1
reach
"In a transgenic mouse model of AD, miR-137 and expression of the CACNA1C gene inhibited the hyperphosphorylation of tau protein."
30102687
CACNA1C binds MAPT.
| 1
CACNA1C binds MAPT. 1 / 1
| 1
reach
"However, the relative interactions between miR-137, p-tau, CACNA1C, and Abeta, and the regulatory effect of miR-137 on the progression of AD in vivo require further investigation."
30102687
CACNA1C affects IQ
| 2
CACNA1C activates IQ. 2 / 2
| 2
reach
"CACNA1C minor allele carriers had larger bilateral caudate, insula, globus pallidus, frontal pole, and nucleus accumbens volumes (smallest r = 0.13, P = 0.043), and increased IQ (r = 0.18, P < 0.001)."
24944871
reach
"CACNA1C minor allele genotypes increased full scale IQ scores independently of increases in total and fronto-limbic brain volumes."
24944871
CACNA1C affects INS
| 1 1
CACNA1C binds INS.
| 1
CACNA1C binds INS and egfp. 1 / 1
| 1
sparser
"Likewise, long-term culture with fatty acids, to emulate the diabetogenic action of a high-fat diet (HFD) ( xref ), decreased binding of EGFP-CaV1.2 to insulin granules ( xref )."
28481223
CACNA1C activates INS.
| 1
CACNA1C activates INS. 1 / 1
| 1
reach
"Further studies confirmed that Cacna1c mRNA and protein are downregulated by miR-153 mimics and upregulated by miR-153 inhibitors in insulin secreting freshly isolated mouse islets, in the insulin secreting mouse cell line MIN6 and in the dopamine secreting cell line PC12."
26141787
CACNA1C affects ICDH
| 2
CACNA1C binds ICDH.
| 1
CACNA1C binds ICDH. 1 / 1
| 1
reach
"Here we investigated whether this CACNA1C variant also associates with ICDH and interacts with SNP rs956572 on [Ca (2+)] B in BD-I."
25843436
CACNA1C activates ICDH.
| 1
CACNA1C activates ICDH. 1 / 1
| 1
reach
"Our study further supports the association of SNP rs1006737 with BD-I and suggests that CACNA1C SNP rs1006737 and Bcl-2 SNP rs956572, or specific causal variants in LD with these proxies, act independently to increase risk and ICDH in BD-I."
25843436
CACNA1C affects CACNB2, ERs, and KCNJ8
| 2
CACNA1C binds CACNB2, KCNJ8, and ERs. 2 / 2
| 2
sparser
"BrS has been associated with mutations in eight different genes including SCN5A, GPD1L, CACNAC1C, CACNb2b, SCN1B, KCNE3, SCN3B and CACNA2D1, whereas ERS has been associated with mutations in KCNJ8, CACNA1C and CACNB2 . xref , xref , xref Haissaguerre and co-workers first associated KCNJ8 with ERS in the case of a young female with frequent (>100) recurrences of VF, which were unresponsive to beta-blockers, lidocaine/mexiletine, verapamil, and amiodarone."
22056721
sparser
"BrS has previously been associated with mutations in 7 different genes, including SCN5A, GPD1L, CACNAC1C, CACNb2b, SCN1B, KCNE3, and SCN3B, whereas ERS has been associated with mutations in KCNJ8, CACNA1C, and CACNB2 . xref , xref , xref Haissaguerre et al xref were the first to associate KCNJ8 with ERS in the case of a young female patient with more than 100 recurrences of VF unresponsive to beta-blockers, lidocaine/mexiletine, verapamil, and amiodarone."
20736095
24,25-Dihydroxyvitamin D affects CACNA1C
| 2
24,25-Dihydroxyvitamin D decreases the amount of CACNA1C. 2 / 2
| 2
reach
"Previous studies have shown that vitamin D treatment decreases CACNA1C messenger RNA expression through the vitamin D receptor (VDR) in primary neuronal cultures."
27123490
reach
"Previous studies have shown that vitamin D inhibits the expression of CACNA1C."
27123490
Trisulfur affects CACNA1C
| 1
Trisulfur inhibits CACNA1C. 1 / 1
| 1
reach
"S3 Loss of CACNA1C in H9c2 cells."
27266387
Synaptotagmin affects CACNA1C
| 1
CACNA1C binds synaptotagmin. 1 / 1
| 1
sparser
"Likewise, expression of the II–III loop fragment of CaV1.2 (amino acids 726–985), which interferes with binding of CaV1.2 to synaptotagmin ( xref ), prevented granule-localized Ca 2+ influx ( xref )."
28481223
Sodium atom affects CACNA1C
| 1
Sodium atom activates CACNA1C. 1 / 1
| 1
reach
"With regards to voltage gated calcium (Ca 2+) channels (XREF_FIG), Na + deficiency significantly upregulated Cacna1i (Ca v 3.3; T-type), Cacna1e (Ca v 2.3; R-type), Cacna1c (Ca v 1.2; L-type) and Cacna1b (Ca v 2.2; N-type)."
28957668
Primer affects CACNA1C
| 1
Primer activates CACNA1C. 1 / 1
| 1
eidos
"In brief , Cav1.2 was amplified by primers : forward : 5 ' - GGGGTACCATGGTCAATGAAAACACGAGG-3 ' , reverse : 5 ' - ATAAGAATGCGGCCGC CTACAGGTTGCTGACGTAGGAC-3 ' from pCaV1.2 ( Addgene , Plasmid # 26572 ) ."
32351759
Phosphate affects CACNA1C
| 1
Phosphate activates CACNA1C. 1 / 1
| 1
sparser
"The L type is allosterically activated by fructose-1,6-bis- 133 phosphate."
7350911
P.R1193Q affects CACNA1C
| 1
P.R1193Q activates CACNA1C-Q1916R. 1 / 1
| 1
reach
"A concomitant gain-of-function variant in the sodium channel gene SCN5A (p.R1193Q) was found to rescue the phenotype of the female CACNA1C Q1916R mutation carriers, which led to the incomplete penetrance."
28493952
MiR-25 cause affects CACNA1C
| 1
MiR-25 cause activates CACNA1C. 1 / 1
| 1
reach
"Surprisingly, we found inhibition of miR-25 cause significantly repress Pde3a and Cacna1c 3 '-UTR luciferase assay, whereas we saw no such repression when we performed similar experiments using overexpression of miR-25."
29499204
MiR-153 inhibitors affects CACNA1C
| 1
MiR-153 inhibitors inhibits CACNA1C. 1 / 1
| 1
reach
"Further studies confirmed that Cacna1c mRNA and protein are downregulated by miR-153 mimics and upregulated by miR-153 inhibitors in insulin secreting freshly isolated mouse islets, in the insulin secreting mouse cell line MIN6 and in the dopamine secreting cell line PC12."
26141787
MiR-153 affects CACNA1C
| 1
MiR-153 inhibits CACNA1C. 1 / 1
| 1
reach
"Finally, miR-153 inhibits Cacna1c to suppress neuroendocrine secretion (insulin and dopamine) 61."
30166527
MiR-137 inhibitor affects CACNA1C
| 1
MiR-137 inhibitor decreases the amount of CACNA1C. 1 / 1
| 1
reach
"Data showed that compared with SH-SY5Y cells transfected with NC-miRNA, miR-137 mimics significantly decreased the protein expression level of CACNA1C, whereas miR-137 inhibitor increased the CACNA1C level in SH-SY5Y cells (XREF_FIG)."
30102687
MiR-137 affects CACNA1C
| 1
MiR-137 activates CACNA1C. 1 / 1
| 1
reach
"58 In neuropsychiatric disease research, the miR-137 gene locus was associated with increased schizophrenia risk with genome-wide significance; moreover, miR-137 targets the genes CSMD1, C10orf26, CACNA1C, and TCF4 which are among schizophrenia associated risk genes."
31636487
Mi-223 affects CACNA1C
| 1
Mi-223 activates CACNA1C. 1 / 1
| 1
reach
"The induction of CACNA1C by mi-223 was further verified by western blotting in neonatal mouse atrial myocytes transfected with miR-223 (XREF_FIG)."
27488468
Hsa-miR-939-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-939-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-920 affects CACNA1C
1 |
Transcriptionally active hsa-miR-920 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-762 affects CACNA1C
1 |
Transcriptionally active hsa-miR-762 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-7106-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-7106-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6857-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-6857-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6825-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-6825-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6810-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-6810-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6791-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-6791-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6780b-3p affects CACNA1C
1 |
Transcriptionally active hsa-miR-6780b-3p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-6778-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-6778-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6763-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-6763-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6754-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-6754-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6726-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-6726-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-623 affects CACNA1C
1 |
Transcriptionally active hsa-miR-623 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-5787 affects CACNA1C
1 |
Transcriptionally active hsa-miR-5787 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-5591-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-5591-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-5006-3p affects CACNA1C
1 |
Transcriptionally active hsa-miR-5006-3p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-5001-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-5001-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4780 affects CACNA1C
1 |
Transcriptionally active hsa-miR-4780 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-4755-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-4755-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-4731-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-4731-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-450a-2-3p affects CACNA1C
1 |
Transcriptionally active hsa-miR-450a-2-3p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4505 affects CACNA1C
1 |
Transcriptionally active hsa-miR-4505 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4498 affects CACNA1C
1 |
Transcriptionally active hsa-miR-4498 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4492 affects CACNA1C
1 |
Transcriptionally active hsa-miR-4492 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4489 affects CACNA1C
1 |
Transcriptionally active hsa-miR-4489 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4487 affects CACNA1C
1 |
Transcriptionally active hsa-miR-4487 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4441 affects CACNA1C
1 |
Transcriptionally active hsa-miR-4441 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4425 affects CACNA1C
1 |
Transcriptionally active hsa-miR-4425 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4300 affects CACNA1C
1 |
Transcriptionally active hsa-miR-4300 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4283 affects CACNA1C
1 |
Transcriptionally active hsa-miR-4283 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4270 affects CACNA1C
1 |
Transcriptionally active hsa-miR-4270 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3938 affects CACNA1C
1 |
Transcriptionally active hsa-miR-3938 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-3175 affects CACNA1C
1 |
Transcriptionally active hsa-miR-3175 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3150a-3p affects CACNA1C
1 |
Transcriptionally active hsa-miR-3150a-3p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3147 affects CACNA1C
1 |
Transcriptionally active hsa-miR-3147 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-29a-3p affects CACNA1C
1 |
Transcriptionally active hsa-miR-29a-3p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27341015
Hsa-miR-2110 affects CACNA1C
1 |
Transcriptionally active hsa-miR-2110 decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-211-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-211-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-208b-3p affects CACNA1C
1 |
Transcriptionally active hsa-miR-208b-3p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27545043
Hsa-miR-208a-3p affects CACNA1C
1 |
Transcriptionally active hsa-miR-208a-3p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27545043
Hsa-miR-204-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-204-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-185-3p affects CACNA1C
1 |
Transcriptionally active hsa-miR-185-3p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-1343-5p affects CACNA1C
1 |
Transcriptionally active hsa-miR-1343-5p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-133a-3p affects CACNA1C
1 |
Transcriptionally active hsa-miR-133a-3p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19136465
Hsa-miR-103a-3p affects CACNA1C
1 |
Transcriptionally active hsa-miR-103a-3p decreases the amount of CACNA1C. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
25627864
Fingolimod hydrochloride affects CACNA1C
| 1
Fingolimod hydrochloride increases the amount of CACNA1C. 1 / 1
| 1
reach
"Besides, FTY-720 induced the overexpression of CACNA1C, nNOS gene, and nitric oxide production."
30623407
Estradiol affects CACNA1C
| 1
Estradiol increases the amount of CACNA1C. 1 / 1
| 1
reach
"Conclusion Exogenous estradiol can increase the left ventricular level of CACNA1C in septic mice."
30554585
Devapamil affects CACNA1C
| 1
Devapamil binds CACNA1C. 1 / 1
| 1
reach
"The purified CaCB receptor bound 0.9 mol devapamil and mol calcium-channel alpha 1 subunit, with an apparent Kd of 13 +/- 2.6 nM at 4 degrees C in the presence of 0.4 microM Ca2+."
1652439
Cre affects CACNA1C
| 1
Cre decreases the amount of CACNA1C. 1 / 1
| 1
reach
"Injection of Cre-GFP significantly reduced the level of Cacna1c expression, as measured by qPCR, in the NAc by ~ 40% (t (17) = 4.43, p < 0.001)."
28186690
Casein affects CACNA1C
| 1
Casein phosphorylates CACNA1C. 1 / 1
| 1
reach
"cAMP kinase, cGMP kinase, protein kinase C, calmodulin kinase II and casein kinase II phosphorylated the 165-kDa and the 55-kDa proteins of the purified CaCB receptor."
2850184
Candidate gene MIR137 affects CACNA1C
| 1
Candidate gene MIR137 activates CACNA1C. 1 / 1
| 1
reach
"For example, the SZ and BD candidate gene MIR137 has been found to target other candidates : CSMD1, C10orf26, CACNA1C, and TCF4 [XREF_BIBR]."
28321286
Caffeine affects CACNA1C
| 1
Caffeine activates CACNA1C. 1 / 1
| 1
reach
"This effect was abolished in cacna1c m231 mutants treated with thapsigargin and caffeine (TgC), a drug combination that depletes SR Ca 2+ stores (XREF_FIG,) suggesting that it is largely due to enhanced SR Ca 2+ release."
20657579
CGMP affects CACNA1C
| 1
CGMP phosphorylates CACNA1C. 1 / 1
| 1
reach
"cAMP kinase, cGMP kinase, protein kinase C, calmodulin kinase II and casein kinase II phosphorylated the 165-kDa and the 55-kDa proteins of the purified CaCB receptor."
2850184
Bop affects CACNA1C
| 1
CACNA1C binds bop. 1 / 1
| 1
sparser
"Previous studies have shown a loss of function of I Ca as the basis for BrS associated with mutations in CACNA1C and CACNB2b. xref , xref As a further test of the hypothesis that loss-of-function mutations in LTCC underlie BrS as well as ERS and some forms of IVF, we are in the process of performing functional studies of the variants uncovered."
20817017
Aconitine affects CACNA1C
| 1
Aconitine increases the amount of CACNA1C. 1 / 1
| 1
reach
"Furthermore, aconitine increased expression of cacna1c, RYR2, atp2a2b, Myh6, troponin C, p38, caspase 3, Bcl-2 and Bax for 12 hours."
31975431
ZNF804A affects CACNA1C
| 1
CACNA1C binds ZNF804A. 1 / 1
| 1
sparser
"In this study, we tested the hypothesis that established genetic risk variants ZNF804A rs1344706 and CACNA1C rs1006737 are associated with psychometric schizotypy and that schizotypy mediates their effect on attention or vice versa."
31076262
YY1 affects CACNA1C
| 1
YY1 increases the amount of CACNA1C. 1 / 1
| 1
reach
"Furthermore, YY1 could activate the transcription of KCNQ1OT1 and CACNA1C."
30241939
VCP affects CACNA1C
1 |
VCP binds CACNA1C. 1 / 1
1 |
biogrid
No evidence text available
21186355
TS2 affects CACNA1C
| 1
CACNA1C binds TS2. 1 / 1
| 1
sparser
"G402S variant in exon 8 of the gene CACNA1C has been previously associated with Timothy Syndrome TS2 (MIM: 601005)."
24773605
TRIM13 affects CACNA1C
1 |
CACNA1C binds TRIM13. 1 / 1
1 |
biogrid
No evidence text available
21186355
TES affects CACNA1C
| 1
CACNA1C binds TES. 1 / 1
| 1
sparser
"Interestingly, nonconserved S and L type sites are associated with TEs more frequently than F and M type sites."
18757892
TENM4 affects CACNA1C
| 1
CACNA1C binds TENM4. 1 / 1
| 1
sparser
"The latest evidence comes from the genome-wide association studies (GWASs) showing and replicating the association of BD with numerous gene polymorphisms such as CACNA1C, ODZ4, and NSAN."
29188027
TCF7L2 affects CACNA1C
| 1
TCF7L2 binds CACNA1C. 1 / 1
| 1
sparser
"This study was not designed to address the prevalence of epistatic interactions involving CACNA1C and TCF7L2 in humans; indeed, we examined null alleles, which are presumably more severe than the corresponding human risk alleles."
27618673
SZ affects CACNA1C
| 1
SZ activates CACNA1C. 1 / 1
| 1
reach
"For example, the SZ and BD candidate gene MIR137 has been found to target other candidates : CSMD1, C10orf26, CACNA1C, and TCF4 [XREF_BIBR]."
28321286
SYNE1 affects CACNA1C
| 1
CACNA1C binds SYNE1. 1 / 1
| 1
sparser
"Two polymorphisms, CACNA1C rs10848683 and SYNE1 rs214950, were significantly associated after the Bonferroni correction ( Fig. 1 )."
27620326
STIM2 affects CACNA1C
| 1
CACNA1C binds STIM2. 1 / 1
| 1
sparser
"Notably, this study assessed that Stim2 does not interact with CaV1.2 and does not suppress voltage-operated Ca 2+ influx ( xref )."
25964739
STAC3 affects CACNA1C
| 1
CACNA1C binds STAC3. 1 / 1
| 1
sparser
"Although Stac3 is not required for surface expression of CaV1.2, the principle subunit of the cardiac/brain L-type Ca(2+) channel, Stac3 does bind to CaV1.2 and, as a result, greatly slows the rate of current inactivation, with Stac2 acting similarly."
25548159
SRF affects CACNA1C
| 1
SRF decreases the amount of CACNA1C. 1 / 1
| 1
reach
"Deficiency of SRF in SMC of Srf knockout (KO) mice led to reduction of SRF dependent DMPK, which down-regulated the expression of CACNA1C."
28152551
SRC affects CACNA1C
1 |
SRC phosphorylates CACNA1C on Y2217. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
SIRT1 affects CACNA1C
1 |
CACNA1C binds SIRT1. 1 / 1
1 |
biogrid
No evidence text available
19343720
SHANK3 affects CACNA1C
| 1
CACNA1C binds SHANK3. 1 / 1
| 1
sparser
"The Shank3 models mimick gene mutations associated with Phelan-McDermid Syndrome and the Cacna1c model recapitulates the deletion underlying Timothy syndrome."
28753255
RyR affects CACNA1C
| 1
CACNA1C binds RyR. 1 / 1
| 1
sparser
"We did not perform immunoprecipitation to determine the potential nature of the interaction between RyR and L type channels since this experiment would only determine a biochemical but not a physiological interaction."
23826376
RbFox proteins affects CACNA1C
| 1
RbFox proteins activates CACNA1C. 1 / 1
| 1
reach
"RbFox proteins, a family of splicing factors implicated in the control of alternative splicing during development, were recently shown to repress e9 * and promote inclusion of e33 of Cacna1c, influencing the composition of Ca V 1.2 mRNAs expressed in the cortex [XREF_BIBR, XREF_BIBR]."
23022282
RUNX2 affects CACNA1C
| 1
Modified RUNX2 increases the amount of CACNA1C. 1 / 1
| 1
reach
"This is concordant with the overexpression of RUNX2 and CACNA1C observed in calcified valves and suggest that newly discovered AS associated variants increase the risk of AS by increasing the mRNA expression levels of RUNX2 and CACNA1C in valve tissue."
26553695
RNApo_II affects CACNA1C
| 1
RNApo_II binds CACNA1C. 1 / 1
| 1
sparser
"Neonatal inflammatory insult increases the acetylation and trimethylation of lysine residue nine on histone H3 to enhance the association of RNA polymerase II with the core promoter region of the Cacna1c ."
21897820
RIMS1 affects CACNA1C
1 |
CACNA1C binds RIMS1. 1 / 1
1 |
hprd
No evidence text available
11438519
RELA affects CACNA1C
| 1
RELA decreases the amount of CACNA1C. 1 / 1
| 1
reach
"XREF_BIBR In addition to DREAM translocation, the effect of CamKII KO may depend on decreased nuclear translocation of the NFkappaB component p65, which suppresses transcription of Cacna1c."
23802033
PPP3 affects CACNA1C
| 1
PPP3 dephosphorylates CACNA1C. 1 / 1
| 1
sparser
"Mutation of the calcineurin-binding site in AKAP79 (AKAP79ΔPIX) allows it to support PKA-dependent up-regulation of CaV1.2 channel activity, suggesting that calcineurin bound to AKAP79 rapidly dephosphorylates CaV1.2 channels, thereby preventing their regulation by PKA."
24567507
PPM1A affects CACNA1C
1 |
CACNA1C binds PPM1A. 1 / 1
1 |
hprd
No evidence text available
15728831
PKC affects CACNA1C
| 1
PKC phosphorylates CACNA1C. 1 / 1
| 1
reach
"cAMP kinase, cGMP kinase, protein kinase C, calmodulin kinase II and casein kinase II phosphorylated the 165-kDa and the 55-kDa proteins of the purified CaCB receptor."
2850184
PCBD1 affects CACNA1C
1 |
CACNA1C binds PCBD1. 1 / 1
1 |
biogrid
No evidence text available
11461190
OMIM 601005 affects CACNA1C
| 1
OMIM 601005 activates mutated CACNA1C. 1 / 1
| 1
reach
"Activating mutations of CACNA1C gene are associated with Timothy syndrome (OMIM 601005), a multisystem disorder characterized by cardiac, hand and foot, facial, and neurodevelopmental features."
21144913
NGF affects CACNA1C
1 |
NGF decreases the amount of CACNA1C. 1 / 1
1 |
bel
"TABLE I Sema 3A regulates gene expression in PC12 cells and hippocampal neurons (PC12+SEMA3A and PC12+NGF columns)"
15155748
NFkappaB affects CACNA1C
| 1
NFkappaB decreases the amount of CACNA1C. 1 / 1
| 1
reach
"XREF_BIBR In addition to DREAM translocation, the effect of CamKII KO may depend on decreased nuclear translocation of the NFkappaB component p65, which suppresses transcription of Cacna1c."
23802033
Mallipattu et al. [ affects CACNA1C
| 1
Mallipattu et al. [ decreases the amount of CACNA1C. 1 / 1
| 1
reach
"Mallipattu et al. [XREF_BIBR] found that ATRA could up-regulate the gene expression of GSTA4, PER2, IFRD1, HIVEP1, LIPE, METTL1, RFX1, SNX5, PLAUR, CLCN3, SFXN4, DMD, FOXC1, KLF15, GDNF, GABARAPL1 and could down-regulate the gene expressions of GATA3, CCND2, ISGF3G, MCAM, SIAT1, FGF18, PITX2, GNB4, WISP1, YWHAZ, CACNA1C in cultured podocytes."
23344030
MYOCD affects CACNA1C
| 1
Modified MYOCD increases the amount of CACNA1C. 1 / 1
| 1
reach
"Overexpression of myocardin in iPSC-MSC enhanced the expression of SCN9A and CACNA1C, but reduced that of KCa3.1 and Kir2.2 in iPSC-MSCs."
24744906
MYC affects CACNA1C
| 1
CACNA1C binds MYC. 1 / 1
| 1
sparser
"This up-regulation of CACNA1C is associated with the expression of the cAMP-responsive element-binding protein (CREB), a known regulator of CACNA1C gene expression, and the MYC gene, which encodes a transcription factor that putatively binds to a site proximal to the CACNA1C gene transcription initiation site."
25807982
MIR155 affects CACNA1C
| 1
MIR155 inhibits CACNA1C. 1 / 1
| 1
reach
"In the meantime, the construction of reporter plasmids and reporter assays showed that miR-155 repressed the Luciferase activity of 3 ' untranslated regions of CACNA1C."
22944230
MARCHF8 affects CACNA1C
| 1
MARCHF8 activates CACNA1C. 1 / 1
| 1
reach
"In standard growth media miR combo significantly induced the expression of the cardiomyocyte markers cardiac troponin-I and Cacna1c (XREF_FIG)."
26975336
MAPT affects CACNA1C
| 1
CACNA1C binds MAPT. 1 / 1
| 1
reach
"However, the relative interactions between miR-137, p-tau, CACNA1C, and Abeta, and the regulatory effect of miR-137 on the progression of AD in vivo require further investigation."
30102687
LTCC affects CACNA1C
| 1
LTCC inhibits CACNA1C. 1 / 1
| 1
reach
"Step # 3 depicts our finding that LTCC blockade remodels ventricular myocytes, and our new findings that CCt interacts with the CACNA1C promoter, and CCt reduces CACNA1C promoter activity."
20447569
ITLN1 affects CACNA1C
| 1
ITLN1 decreases the amount of CACNA1C. 1 / 1
| 1
reach
"HL-1 atrial cardiomyocytes transfected with miR-29 and miR-200 (XREF_FIG) significantly down-regulate Cacna1c, Hnc4 and Ryr2 expression, while Camk2a was significantly decreased with miR-200 but not miR-29 (XREF_FIG)."
29194452
ICDH affects CACNA1C
| 1
CACNA1C binds ICDH. 1 / 1
| 1
reach
"Here we investigated whether this CACNA1C variant also associates with ICDH and interacts with SNP rs956572 on [Ca (2+)] B in BD-I."
25843436
HDAC4 affects CACNA1C
1 |
CACNA1C binds HDAC4. 1 / 1
1 |
biogrid
No evidence text available
21464227
HAND2-AS1 affects CACNA1C
| 1
CACNA1C binds HAND2-AS1. 1 / 1
| 1
reach
"For example, HAND2-AS1 interacted with SLC2A4, ZFPM2, CACNA1C and ABL1 mediated by mir-93, mir-141, mir-133a-1 and mir-30a, respectively."
27863388
GPBAR1 affects CACNA1C
| 1
GPBAR1 activates CACNA1C. 1 / 1
| 1
reach
"This effect of GPBAR-A was not observed in the presence of the L-type Ca 2+ channel blocker nifedipine (50muM), suggesting that GPBAR1 activation enhances the activity of L-type Ca 2+ channels, consistent with the known modulation of these ion channels by PKA XREF_BIBR."
29167062
GNB1 affects CACNA1C
1 |
CACNA1C binds GNB1. 1 / 1
1 |
hprd
No evidence text available
15953418
FSD1 affects CACNA1C
| 1
Modified FSD1 decreases the amount of CACNA1C. 1 / 1
| 1
reach
"Loss of miR-1 also leads to the expression of GJA1 (connexin 43) and CACNA1C (Cav1.2) to generate calcium- and gap-junction channels in myotonic dystrophy 36."
29034995
FLVCR2 affects CACNA1C
| 1
FLVCR2 inhibits CACNA1C. 1 / 1
| 1
reach
"Step # 3 depicts our finding that LTCC blockade remodels ventricular myocytes, and our new findings that CCt interacts with the CACNA1C promoter, and CCt reduces CACNA1C promoter activity."
20447569
EZH2 affects CACNA1C
| 1
EZH2 inhibits CACNA1C. 1 / 1
| 1
reach
"Initial interrogation of ENCODE ChIP-seq data over the CACNA1C promoter indicated binding of the transcription factor ' Enhancer of zeste homolog 2 ' (EZH2), which was consistent with our data that overexpression of EZH2 repressed CACNA1C promoter reporter gene expression."
29501388
EIF3E affects CACNA1C
| 1 1
CACNA1C binds EIF3E. 1 / 1
| 1 1
sparser
"We define a domain in the II-III loop of CaV1.2 that binds eIF3e and is essential for the activity dependence of both channel internalization and endosomal trafficking."
17698014
DsRed affects CACNA1C
| 1
CACNA1C binds DsRed. 1 / 1
| 1
sparser
"To study this process in live BMSCs, we used Dio to label the cell membrane (FITC-labeled) and constructed a plasmid to express Ca V 1.2 (DsRed-Cav1.2) to use in the transfection of cells."
32351759
DMPK affects CACNA1C
| 1
DMPK decreases the amount of CACNA1C. 1 / 1
| 1
reach
"Deficiency of SRF in SMC of Srf knockout (KO) mice led to reduction of SRF dependent DMPK, which down-regulated the expression of CACNA1C."
28152551
DLPFC affects CACNA1C
| 1
DLPFC activates CACNA1C. 1 / 1
| 1
reach
"We did not replicate the previous findings of increased right DLPFC activation in CACNA1C rs1006737 A homozygotes."
23404764
DERL1 affects CACNA1C
1 |
CACNA1C binds DERL1. 1 / 1
1 |
biogrid
No evidence text available
21186355
CUL1 affects CACNA1C
1 |
CACNA1C binds CUL1. 1 / 1
1 |
biogrid
No evidence text available
21145461
CSNK2A1 affects CACNA1C
1 |
CSNK2A1 phosphorylates CACNA1C on T1704. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CSDS affects CACNA1C
| 1
CSDS inhibits CACNA1C. 1 / 1
| 1
reach
"Moreover, CSDS increased the latency to enter the lit compartment and decreased the time spent in the lit zone and number of lit entries to a much greater extent in Cav1.2 Het than in Cav1.2 Ctrl mice (XREF_FIG), further supporting increased stress induced anxiety in heterozygous Cacna1c mice."
28696432
COPS5 affects CACNA1C
1 |
CACNA1C binds COPS5. 1 / 1
1 |
biogrid
No evidence text available
16483597
CLOCK-BMAL1 affects CACNA1C
| 1
Modified CLOCK-BMAL1 decreases the amount of CACNA1C. 1 / 1
| 1
reach
"Overexpressions of CLOCK-BMAL1 significantly reduced the levels of CACNA1C while increasing the levels of pAkt T308 and pik3r1."
27376484
CHRNA7 affects CACNA1C
| 1
CACNA1C binds CHRNA7. 1 / 1
| 1
sparser
"Therefore, miR-137 inhibited the expression of CACNA1C by directly binding to the 3′-UTR of CACNA1C mRNA in SH-SY5Y cells."
30102687
CELF1 affects CACNA1C
| 1
CELF1 increases the amount of CACNA1C. 1 / 1
| 1
reach
"Furthermore, the resultant decrease in DMPK expression may switch the preferential expression of MBNL1 to CELF1, which may suppress expression of the L-type calcium channel CACNA1C."
28152551
CAV1 affects CACNA1C
| 1
CAV1 activates CACNA1C. 1 / 1
| 1
reach
"A role of Cav1.2 is also supported from genome-wide association studies linking intronic CACNA1C SNPs with enhanced risk for a range of psychiatric disorders of childhood and adult onset, including bipolar disease and ASD [XREF_BIBR, XREF_BIBR]."
25966690
CASP3 affects CACNA1C
| 1
CASP3 activates CACNA1C. 1 / 1
| 1
reach
"There was, however, compromised mitochondrial respiration characterised by decreased ATP synthesis driven respiration (p < 0.05) and increased uncoupled respiration (p < 0.01), reduced docked insulin granules (p < 0.001), decreased Cacna1c (p < 0.001) and Cacna1d (p < 0.001) and increased cleaved caspase-3 expression (p < 0.05)."
31773193
CAND1 affects CACNA1C
1 |
CACNA1C binds CAND1. 1 / 1
1 |
biogrid
No evidence text available
21145461
CALM1 affects CACNA1C
1 |
CACNA1C binds CALM1. 1 / 1
1 |
biogrid
No evidence text available
16338416
CACNA1C affects vanoxerine
| 1
CACNA1C inhibits vanoxerine. 1 / 1
| 1
reach
"Moreover, reduced levels of Cacna1c in the VTA, but not the NAc, led to attenuation of sensitization to GBR12909."
28186690
CACNA1C affects translation
| 1
CACNA1C inhibits translation. 1 / 1
| 1
reach
"Cacna1c forebrain knockout mice have decreased initiation of mRNA translation in the PFC. Alterations in protein synthesis, via dysregulated cap dependent mRNA translation have been shown to underlie social deficits XREF_BIBR, XREF_BIBR and anxiety."
28584287
CACNA1C affects transcription, DNA-templated
| 1
CACNA1C inhibits transcription, DNA-templated. 1 / 1
| 1
reach
"Moreover, both Cacna1c knockdown and LTCC blockade probably lead to altered Ca V 1.2-dependent gene transcription regulation and may suppress toxic mitochondrial Ca 2+ uptake via transcriptional repression of enhanced MCU expression following glutamate treatment in HT22 cells 35."
29760952
CACNA1C affects synaptotagmin
| 1
CACNA1C binds synaptotagmin. 1 / 1
| 1
sparser
"Likewise, expression of the II–III loop fragment of CaV1.2 (amino acids 726–985), which interferes with binding of CaV1.2 to synaptotagmin ( xref ), prevented granule-localized Ca 2+ influx ( xref )."
28481223
CACNA1C affects soil urease
| 1
CACNA1C activates soil urease. 1 / 1
| 1
reach
"Compared with CK, CaCN2 effectively increased soil urease, catalase and polyphenol oxidase activity."
26995916
CACNA1C affects sodium atom
| 1
CACNA1C inhibits sodium atom. 1 / 1
| 1
reach
"Multiple mutations of genes, SCN5A, SCN1B, SCN3B, GPD1L, CACNA1C, CACNB2, KCNE3 and KCND3, have been shown to decrease cardiac Na + and Ca 2+ channel activity or increase fast transient outward K + channel activity, and they are linked to BrS."
26016905
CACNA1C affects release calcium
| 1
CACNA1C activates release calcium. 1 / 1
| 1
eidos
"ATP2A1 , RYR2 , RYR1 , CACNA1C , CACNA1D , and CACNA1S mediate the release of calcium , thereby playing a key role in triggering cardiac muscle contraction and maintaining the calcium homeostasis [ 56,57 ] ."
30231506
CACNA1C affects pyraclofos
| 1
CACNA1C inhibits pyraclofos. 1 / 1
| 1
reach
"In summary, the combined effects of the CACNA1C variant to diminish voltage dependent inactivation of Ca V 1.2 and increase window current expand our appreciation of mechanisms by which a gain of function of Ca V 1.2 can contribute to QT prolongation."
25184293
CACNA1C affects process
| 1
CACNA1C inhibits process. 1 / 1
| 1
sparser
"For example, the calcium-dependent cytosolic phosphatase calcineurin dephosphorylates Drp1 thereby promoting its translocation to mitochondria and triggering detrimental mitochondrial fission; a process that is likely inhibited by Cacna1c gene silencing xref ."
29760952
CACNA1C affects polyphenol oxidase
| 1
CACNA1C activates polyphenol oxidase. 1 / 1
| 1
reach
"Compared with CK, CaCN2 effectively increased soil urease, catalase and polyphenol oxidase activity."
26995916
CACNA1C affects miR-149-5p
| 1
CACNA1C activates miR-149-5p. 1 / 1
| 1
reach
"This network reveals five putative direct targets : CACNA1C (Calcium channel) target of miR-149-5p; GJA5 (Gap Junction protein, alpha 5), RNF207 (Ring finger protein 207) and KCNA1 (potassium voltage gated channel shaker related subfamily, member 1) targets of miR-145-5p; KCNA1 which is also a miR-21-5p target; and finally, SLC18A2 (Solute carrier family 18 member 2) target of miR-142-5p."
26086673
CACNA1C affects miR-135b
| 1
CACNA1C binds miR-135b. 1 / 1
| 1
reach
"Luciferase reporter assays were used to testify the binding of miR-135b to the CACNA1C 3 ' UTR."
30037628
CACNA1C affects localization
| 1
CACNA1C activates localization. 1 / 1
| 1
reach
"Co-injection of cacna1c morpholinos with either Ca V 1.2 WT cRNA (XREF_FIG) or Ca V 1.2 TS cRNA (XREF_FIG) led to rescue of contractile function in the majority of treated embryos (66.7% of cRNA rescue animals had a beating heart at 48 hpf compared with 5% of embryos treated with cacna1c morpholinos alone, P < 0.0001) suggesting proper expression, localization, and function of the rescue channels."
25536179
CACNA1C affects inflammatory response
| 1
CACNA1C inhibits inflammatory response. 1 / 1
| 1
reach
"Reduced transcription of Cacna1c contributes to smooth muscle dysfunction in the absence of inflammation."
21745450
CACNA1C affects hexadecane
| 1
CACNA1C activates hexadecane. 1 / 1
| 1
reach
"Although this has yet to be confirmed, data from post-mortem brain tissue indicate that carriers of the A allele have increased CACNA1C mRNA production in the CNS."
22290120
CACNA1C affects glutathione
| 1
CACNA1C inhibits glutathione. 1 / 1
| 1
reach
"Furthermore it was suggested that CaCN2 causes a lack of reduced glutathione in the organism."
7269862
CACNA1C affects devapamil
| 1
Devapamil binds CACNA1C. 1 / 1
| 1
reach
"The purified CaCB receptor bound 0.9 mol devapamil and mol calcium-channel alpha 1 subunit, with an apparent Kd of 13 +/- 2.6 nM at 4 degrees C in the presence of 0.4 microM Ca2+."
1652439
CACNA1C affects cn
| 1
CACNA1C inhibits cn. 1 / 1
| 1
reach
"The addition of CaCN 2 increased the percent T-N but decreased C/N ratio during composting."
27800167
CACNA1C affects cellular senescence
| 1
CACNA1C activates cellular senescence. 1 / 1
| 1
reach
"Finally, our results prove that the upregulation of Ca 2+ entry through Ca v 1.2 channels leads to cell death, and that stable knocking-down of CACNA1C gene transcripts restores the mitochondrial function and senescence to basal levels."
30088035
CACNA1C affects cell population proliferation
| 1
CACNA1C activates cell population proliferation. 1 / 1
| 1
reach
"Similarly, under basal conditions in vivo, Cacna1c gene deletion in type-1 cells decreased type-1 cell proliferation and reduced the neuronal fate-choice decision of newly born cells, resulting in reduced net hippocampal neurogenesis."
28230278
CACNA1C affects cell
| 1
CACNA1C activates cell. 1 / 1
| 1
eidos
"IAV entry was inhibited by Ca2 + channel blockers ; however , knockdown of Cav1.2 decreased the number of IAV-infected cells only twofold ."
31629602
CACNA1C affects bop
| 1
CACNA1C binds bop. 1 / 1
| 1
sparser
"Previous studies have shown a loss of function of I Ca as the basis for BrS associated with mutations in CACNA1C and CACNB2b. xref , xref As a further test of the hypothesis that loss-of-function mutations in LTCC underlie BrS as well as ERS and some forms of IVF, we are in the process of performing functional studies of the variants uncovered."
20817017
CACNA1C affects apoptotic process
| 1
CACNA1C inhibits apoptotic process. 1 / 1
| 1
reach
"In mast cells, however, Cacna1c knockdown augmented apoptosis after IgE stimulation by disrupting mitochondrial integrity, emphasizing that the maintenance of an appropriate mitochondrial calcium concentration is also essential for cell survival 60."
29760952
CACNA1C affects alpha1 subunit
| 1
CACNA1C activates alpha1 subunit. 1 / 1
| 1
reach
"The CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E and CACNA1G genes produce various isoform of alpha1 subunit including A, B, C, D, E and G, respectively."
24768178
CACNA1C affects ZNF804A
| 1
CACNA1C binds ZNF804A. 1 / 1
| 1
sparser
"In this study, we tested the hypothesis that established genetic risk variants ZNF804A rs1344706 and CACNA1C rs1006737 are associated with psychometric schizotypy and that schizotypy mediates their effect on attention or vice versa."
31076262
CACNA1C affects Voltage_gated_ion_channels, and ryanodine receptor
| 1
Voltage_gated_ion_channels binds CACNA1C and ryanodine receptor. 1 / 1
| 1
sparser
"These data indicate that ryanodine receptors may be interacting with the L type voltage gated calcium channels."
23826376
CACNA1C affects VCP
1 |
VCP binds CACNA1C. 1 / 1
1 |
biogrid
No evidence text available
21186355
CACNA1C affects TSC1/2
| 1
Modified CACNA1C leads to the dephosphorylation of TSC1/2. 1 / 1
| 1
reach
"89 Thus, we hypothesize that loss of cacna1c resulting in deficient Ca v 1.2 signaling may inhibit Akt that subsequently (1) suppresses phosphorylation of TSC1/2 and increases its inhibitory effect on mTORC1 phosphorylation, and separately (2) activates PERK and induces eIF2alpha phosphorylation."
28584287
CACNA1C affects TS2
| 1
CACNA1C binds TS2. 1 / 1
| 1
sparser
"G402S variant in exon 8 of the gene CACNA1C has been previously associated with Timothy Syndrome TS2 (MIM: 601005)."
24773605
CACNA1C affects TRIM13
1 |
CACNA1C binds TRIM13. 1 / 1
1 |
biogrid
No evidence text available
21186355
CACNA1C affects TES
| 1
CACNA1C binds TES. 1 / 1
| 1
sparser
"Interestingly, nonconserved S and L type sites are associated with TEs more frequently than F and M type sites."
18757892
CACNA1C affects TENM4
| 1
CACNA1C binds TENM4. 1 / 1
| 1
sparser
"The latest evidence comes from the genome-wide association studies (GWASs) showing and replicating the association of BD with numerous gene polymorphisms such as CACNA1C, ODZ4, and NSAN."
29188027
CACNA1C affects TCF7L2
| 1
TCF7L2 binds CACNA1C. 1 / 1
| 1
sparser
"This study was not designed to address the prevalence of epistatic interactions involving CACNA1C and TCF7L2 in humans; indeed, we examined null alleles, which are presumably more severe than the corresponding human risk alleles."
27618673
CACNA1C affects SYNE1
| 1
CACNA1C binds SYNE1. 1 / 1
| 1
sparser
"Two polymorphisms, CACNA1C rs10848683 and SYNE1 rs214950, were significantly associated after the Bonferroni correction ( Fig. 1 )."
27620326
CACNA1C affects SVF
| 1
CACNA1C activates SVF. 1 / 1
| 1
reach
"Moreover, impairments of language processing and altered responses in prefrontal regions including IFG have been reported in first-degree relatives of depressed patients (Christensen et al., 2006; Joormann et al., 2012; Wolfensberger et al., 2008; Young et al., 2013), potentially indicating an association of these variables with genetic liability to depression.Based on this evidence, we tested the hypothesis that the CACNA1C rs1006737 risk allele modulates SVF performance as well as SVF related neural responses in MDD patients."
24612926
CACNA1C affects STIM2
| 1
CACNA1C binds STIM2. 1 / 1
| 1
sparser
"Notably, this study assessed that Stim2 does not interact with CaV1.2 and does not suppress voltage-operated Ca 2+ influx ( xref )."
25964739
CACNA1C affects STAC3
| 1
CACNA1C binds STAC3. 1 / 1
| 1
sparser
"Although Stac3 is not required for surface expression of CaV1.2, the principle subunit of the cardiac/brain L-type Ca(2+) channel, Stac3 does bind to CaV1.2 and, as a result, greatly slows the rate of current inactivation, with Stac2 acting similarly."
25548159
CACNA1C affects SNCG
| 1
CACNA1C activates SNCG. 1 / 1
| 1
reach
"In previous simulation studies, it has been shown that changes in I CaL due to gain-of-function mutations in CACNA1C prolongs action potential duration linked to early afterdepolarizations, and increases SR calcium content which is then responsible for spontaneous calcium release and delayed afterdepolarizations."
29046645
CACNA1C affects SMBC
| 1
CACNA1C activates SMBC. 1 / 1
| 1
reach
"Compared with CK, CaCN2 increased SMBC in 0-20 cm soil layer at late-fruit stage, and increased SMBN in 0-10 cm soil layer at mid- and late-fruit stages, however there was no significant trend among CaCN2 treatments in the first year (2012), while in the second year (2013) SMBN increased with the increasing CaCN2 amount after mid-fruit stage."
26995916
CACNA1C affects SLC18A2
| 1
CACNA1C inhibits SLC18A2. 1 / 1
| 1
reach
"This network reveals five putative direct targets : CACNA1C (Calcium channel) target of miR-149-5p; GJA5 (Gap Junction protein, alpha 5), RNF207 (Ring finger protein 207) and KCNA1 (potassium voltage gated channel shaker related subfamily, member 1) targets of miR-145-5p; KCNA1 which is also a miR-21-5p target; and finally, SLC18A2 (Solute carrier family 18 member 2) target of miR-142-5p."
26086673
CACNA1C affects SIRT1
1 |
CACNA1C binds SIRT1. 1 / 1
1 |
biogrid
No evidence text available
19343720
CACNA1C affects SHANK3
| 1
CACNA1C binds SHANK3. 1 / 1
| 1
sparser
"The Shank3 models mimick gene mutations associated with Phelan-McDermid Syndrome and the Cacna1c model recapitulates the deletion underlying Timothy syndrome."
28753255
CACNA1C affects SCD
| 1
CACNA1C-Q1916R activates SCD. 1 / 1
| 1
reach
"Here, we presented a rare large Chinese family with ER associated SCD, in which the disease phenotypes were mainly caused by a CACNA1C Q1916R mutation and modulated by the SCN5A-R1193Q variant and sex (XREF_FIG)."
28493952
CACNA1C affects RyR
| 1
CACNA1C binds RyR. 1 / 1
| 1
sparser
"We did not perform immunoprecipitation to determine the potential nature of the interaction between RyR and L type channels since this experiment would only determine a biochemical but not a physiological interaction."
23826376
CACNA1C affects RUNX2
| 1
Modified CACNA1C increases the amount of RUNX2. 1 / 1
| 1
reach
"This is concordant with the overexpression of RUNX2 and CACNA1C observed in calcified valves and suggest that newly discovered AS associated variants increase the risk of AS by increasing the mRNA expression levels of RUNX2 and CACNA1C in valve tissue."
26553695
CACNA1C affects RNApo_II
| 1
RNApo_II binds CACNA1C. 1 / 1
| 1
sparser
"Neonatal inflammatory insult increases the acetylation and trimethylation of lysine residue nine on histone H3 to enhance the association of RNA polymerase II with the core promoter region of the Cacna1c ."
21897820
CACNA1C affects RNA-binding
| 1
CACNA1C activates RNA-binding. 1 / 1
| 1
reach
"RNA sequencing analysis has suggested that CACNA1C is a potential target of the splicing factor RNA binding protein motif 20 (RBM20)."
31717392
CACNA1C affects RIMS1
1 |
CACNA1C binds RIMS1. 1 / 1
1 |
hprd
No evidence text available
11438519
CACNA1C affects RHOA
| 1
CACNA1C activates RHOA. 1 / 1
| 1
reach
"2 CACNA1C modulates BMP signaling in the hair follicle 5, RhoA in neurons 6, and calcineurin-NFAT in chondrocytes 7."
25900989
CACNA1C affects RANGAP1
| 1
CACNA1C activates RANGAP1. 1 / 1
| 1
reach
"Some mutations in the CACNA1C gene were first identified in Timothy syndrome, causing extreme QT prolongation and SD 18."
30279520
CACNA1C affects Parkinson Disease
| 1
CACNA1C activates Parkinson Disease. 1 / 1
| 1
reach
"19 Our data demonstrate that genetic variations in CACNA1C and vitamin D deficiency act together to increase PD risk."
27123490
CACNA1C affects PSMD4
| 1
CACNA1C activates PSMD4. 1 / 1
| 1
reach
"Underexpression of CACNA1C Caused by Overexpression of microRNA-29a Underlies the Pathogenesis of Atrial Fibrillation."
27341015
CACNA1C affects PPM1A
1 |
CACNA1C binds PPM1A. 1 / 1
1 |
hprd
No evidence text available
15728831
CACNA1C affects PPARGC1A
| 1
CACNA1C decreases the amount of PPARGC1A. 1 / 1
| 1
reach
"In glutamate treated HT22 cells, Cacna1c knockdown led to elevated PGC1alpha levels, contrary to controls showing slightly decreased levels."
29760952
CACNA1C affects PCBD1
1 |
CACNA1C binds PCBD1. 1 / 1
1 |
biogrid
No evidence text available
11461190
CACNA1C affects NMDAR
| 1
CACNA1C inhibits NMDAR. 1 / 1
| 1
reach
"In view of our results that developmental inactivation of Cacna1c from glutamatergic neurons decreases NMDA receptor (NMDAR)-dependent synaptic plasticity and impairs spatial memory, we additionally assessed hippocampal LTP in Cav1.2-Ad Glu CKO mice."
28696432
CACNA1C affects NMDA receptor
| 1
CACNA1C inhibits NMDA receptor. 1 / 1
| 1
reach
"In view of our results that developmental inactivation of Cacna1c from glutamatergic neurons decreases NMDA receptor (NMDAR)-dependent synaptic plasticity and impairs spatial memory, we additionally assessed hippocampal LTP in Cav1.2-Ad Glu CKO mice."
28696432
CACNA1C affects NLRP1
| 1
CACNA1C inhibits NLRP1. 1 / 1
| 1
reach
"Cacna1c Knockdown in the NAc Increases Anxiety."
28165117
CACNA1C affects MYC
| 1
CACNA1C binds MYC. 1 / 1
| 1
sparser
"This up-regulation of CACNA1C is associated with the expression of the cAMP-responsive element-binding protein (CREB), a known regulator of CACNA1C gene expression, and the MYC gene, which encodes a transcription factor that putatively binds to a site proximal to the CACNA1C gene transcription initiation site."
25807982
CACNA1C affects ML-DA
| 1
CACNA1C activates ML-DA. 1 / 1
| 1
reach
"Overall, the data in this study indicate that Cacna1c modulates ML-DA dependent behavior and DA terminal dynamics, potentially through altered DA reuptake by VTA neurons."
28186690
CACNA1C affects LTP
| 1
CACNA1C inhibits LTP. 1 / 1
| 1
reach
"In contrast to a developmental inactivation, deletion of Cacna1c from forebrain glutamatergic neurons during adulthood blocked the adverse effects of CSDS on anxiety, enhanced LTP and improved hippocampus dependent cognitive flexibility during the WCM, without affecting long-term memory."
28696432
CACNA1C affects Kir2.2
| 1
CACNA1C inhibits Kir2.2. 1 / 1
| 1
reach
"Overexpression of myocardin in iPSC-MSC enhanced the expression of SCN9A and CACNA1C, but reduced that of KCa3.1 and Kir2.2 in iPSC-MSCs."
24744906
CACNA1C affects INS, and egfp
| 1
CACNA1C binds INS and egfp. 1 / 1
| 1
sparser
"Likewise, long-term culture with fatty acids, to emulate the diabetogenic action of a high-fat diet (HFD) ( xref ), decreased binding of EGFP-CaV1.2 to insulin granules ( xref )."
28481223
CACNA1C affects HTR1A
| 1
CACNA1C activates HTR1A. 1 / 1
| 1
reach
"Moreover, Cacna1c knockout mice display enhanced Fos expression in caudal DR 5-HT neurons and an enhanced response to a 5-HT1A receptor antagonist in rostral DR 5-HT neurons, indicating that loss of Cacna1c disrupts both 5-HT neuron activation and 5-HT1A dependent feedback inhibition across the caudal to rostral DR. Collectively, these results reveal an important role for 5-HT neuron Cav1.2 LTCCs in stress coping behavior and 5-HT1A receptor function."
30176250
CACNA1C affects HDAC4
1 |
CACNA1C binds HDAC4. 1 / 1
1 |
biogrid
No evidence text available
21464227
CACNA1C affects HAND2-AS1
| 1
CACNA1C binds HAND2-AS1. 1 / 1
| 1
reach
"For example, HAND2-AS1 interacted with SLC2A4, ZFPM2, CACNA1C and ABL1 mediated by mir-93, mir-141, mir-133a-1 and mir-30a, respectively."
27863388
CACNA1C affects GOPC
| 1
CACNA1C-R858H activates GOPC. 1 / 1
| 1
reach
"In this study, we focus on the mechanisms by which altered I CaL caused by a R858H CACNA1C mutation promotes and perpetuates ventricular arrhythmia using mathematical modeling."
29046645
CACNA1C affects GNB1
1 |
CACNA1C binds GNB1. 1 / 1
1 |
hprd
No evidence text available
15953418
CACNA1C affects FGF9
| 1
CACNA1C activates FGF9. 1 / 1
| 1
reach
"We investigated whether CACNA1C sex-dependently modulates longitudinal GAF scores and recovery from episodes of psychiatric disturbance in the above mentioned disorders."
26475575
CACNA1C affects ER
| 1
CACNA1C-Q1916R activates ER. 1 / 1
| 1
reach
"Here, we presented a rare large Chinese family with ER associated SCD, in which the disease phenotypes were mainly caused by a CACNA1C Q1916R mutation and modulated by the SCN5A-R1193Q variant and sex (XREF_FIG)."
28493952
CACNA1C affects EIF3E
| 1 1
CACNA1C binds EIF3E. 1 / 1
| 1 1
sparser
"We define a domain in the II-III loop of CaV1.2 that binds eIF3e and is essential for the activity dependence of both channel internalization and endosomal trafficking."
17698014
CACNA1C affects EIF2S1
| 1
Modified CACNA1C leads to the phosphorylation of EIF2S1. 1 / 1
| 1
reach
"89 Thus, we hypothesize that loss of cacna1c resulting in deficient Ca v 1.2 signaling may inhibit Akt that subsequently (1) suppresses phosphorylation of TSC1/2 and increases its inhibitory effect on mTORC1 phosphorylation, and separately (2) activates PERK and induces eIF2alpha phosphorylation."
28584287
CACNA1C affects DsRed
| 1
CACNA1C binds DsRed. 1 / 1
| 1
sparser
"To study this process in live BMSCs, we used Dio to label the cell membrane (FITC-labeled) and constructed a plasmid to express Ca V 1.2 (DsRed-Cav1.2) to use in the transfection of cells."
32351759
CACNA1C affects DERL1
1 |
CACNA1C binds DERL1. 1 / 1
1 |
biogrid
No evidence text available
21186355
CACNA1C affects CXXC1, and SNP
| 1
CACNA1C binds CXXC1 and SNP. 1 / 1
| 1
sparser
"A Dutch study found that CACNA1C CpG-SNP (rs1990322) was significantly associated with PTSD in traumatized police and children and may also interact with the FKBP5 antagonist FKBP4 [ xref ]."
30781888
CACNA1C affects CUL1
1 |
CACNA1C binds CUL1. 1 / 1
1 |
biogrid
No evidence text available
21145461
CACNA1C affects CSMD1, and TCF4
| 1
TCF4 binds CACNA1C and CSMD1. 1 / 1
| 1
sparser
"Such noncoding pre-miR variants may modulate the posttranscriptional regulation of gene expression and thereby be associated with diseases; for example, single nucleotide polymorphisms in pre-miR-27a, pre-miR-196a2, pre-miR-423, and pre-miR-618 were strongly associated with breast cancer risk. xref In neuropsychiatric disease research, the miR-137 gene locus was associated with increased schizophrenia risk with genome-wide significance; moreover, miR-137 targets the genes CSMD1 , C10orf26 , CACNA1C , and TCF4 which are among schizophrenia-associated risk genes. xref Expressing noncoding variants of miR-137 schizophrenia-associated single nucleotide polymorphism alleles in human neurons led to increased miR-137 expression and gain-of-function, resulting in impaired vesicle release in vitro, along with deficits in hippocampus-dependent learning and memory in mice. xref The same study demonstrated that sequestering endogenous miR-137 by a “sponge” construct (compared with an empty vector backbone as control) corrected the anomalous synaptic phenotypes induced by these miR-137 variants."
31636487
CACNA1C affects CREB1
| 1
CACNA1C binds CREB1. 1 / 1
| 1
reach
"Finally, we did not detect an association between CACNA1c, CREB1, or GRIA3, and sleep behaviors."
26739645
CACNA1C affects COPS5
1 |
CACNA1C binds COPS5. 1 / 1
1 |
biogrid
No evidence text available
16483597
CACNA1C affects COMT, DRD2, GAD1, GRM3, KCNH2, MTHFR, and RGS4
| 1
RGS4 binds CACNA1C, COMT, DRD2, GAD1, GRM3, KCNH2, and MTHFR. 1 / 1
| 1
sparser
"Illustrative of genetic vulnerability maps of brain function based on imaging genetics approaches, Rasetti et al reviewed neuroimaging intermediate phenotypes of schizophrenia and the gene variants associated with them, catalogued by cognitive task. xref For example, working memory tasks have revealed abnormal engagement of: dorsolateral prefrontal cortex associated with CACNA1C, COMT, GAD1, GRM3, DRD2, KCNH2, MTHFR, and RGS4; ventrolateral prefrontal cortex associated with COMT, PRODH, and RGS4; thalamus and hippocampus associated with NRG1, DAOA/G72, and DISCI; and parietal lobe associated with PRODH."
24174900
CACNA1C affects CHRNA7
| 1
CACNA1C binds CHRNA7. 1 / 1
| 1
sparser
"Therefore, miR-137 inhibited the expression of CACNA1C by directly binding to the 3′-UTR of CACNA1C mRNA in SH-SY5Y cells."
30102687
CACNA1C affects CFP, and SNP
| 1
CACNA1C binds CFP and SNP. 1 / 1
| 1
sparser
"A recent demonstration that this SNP is associated with changes in PFC CACNA1C expression ( xref ) suggests that the neural effects of the SNP may be attributable to alterations in gene expression."
22085483
CACNA1C affects CAV3, and SCN5A
| 1
SCN5A binds CACNA1C and CAV3. 1 / 1
| 1
sparser
"Mutations of SCN5A, CACNA1C and CAV3 are associated with ventricular tachycardia, long-QT syndromes (LQT3,8,9), and sudden cardiac death while mutations of HCN4 cause sick sinus syndrome type 2 xref ."
20300641
CACNA1C affects CAV1
| 1
CACNA1C inhibits CAV1. 1 / 1
| 1
reach
"In summary, the combined effects of the CACNA1C variant to diminish voltage dependent inactivation of CaV1.2 and increase window current expand our appreciation of mechanisms by which a gain of function of CaV1.2 can contribute to QT prolongation."
25184293
CACNA1C affects CAT
| 1
CACNA1C activates CAT. 1 / 1
| 1
reach
"Compared with CK, CaCN2 effectively increased soil urease, catalase and polyphenol oxidase activity."
26995916
CACNA1C affects CAND1
1 |
CACNA1C binds CAND1. 1 / 1
1 |
biogrid
No evidence text available
21145461
CACNA1C affects CALM1
1 |
CACNA1C binds CALM1. 1 / 1
1 |
biogrid
No evidence text available
16338416
CACNA1C affects CALM
| 5 1
CALM binds CACNA1C. 1 / 1
| 5 1
sparser
"Ca 2+ -CaM and CaV1.2 interaction is a dual-direction regulation on L-type calcium channel, including Ca 2+ -dependent facilitation (CDF) and Ca 2+ -dependent inactivation (CDI)."
26544729
CACNA1C affects CACNA2D1, Calcium_channels, and Sudden Infant Death
| 1
Calcium_channels binds CACNA1C, CACNA2D1, and Sudden Infant Death. 1 / 1
| 1
sparser
"It may even be higher, given that conventional genetic analysis may fail to uncover severe mutations [ xref – xref ] and that the determination of associations between SIDS and mutations in ion channel-related genes is still an emerging field, with several associations that have only recently been reported [ xref – xref ] and others that remain to be assessed, for example, a possible association between SIDS and mutations in the L-type calcium channel-related genes CACNA1C , CACNB2b, and CACNA2D1 , which have been associated with LQTS, BrS, and SQTS ( xref – xref )."
23304551
CACNA1C affects CACNA2D1, CACNB2, and ERs
| 1
CACNA1C binds CACNA2D1, CACNB2, and ERs. 1 / 1
| 1
sparser
"Mutations in only one gene, KCNJ8 , have thus far been associated with ERS. xref , xref The present study identifies four probands in whom mutations in highly conserved residues of CACNA1C, CACNB2, and CACNA2D1 are associated with ERS, suggesting linkage of these genes with ERS."
20817017
CACNA1C affects CACNA1D, and stim1
| 1
CACNA1C binds CACNA1D and stim1. 1 / 1
| 1
sparser
"At the same time, Stim1 interaction with CaV1.2 and CaV1.3 could help understanding Stim1 and Orai1 co-localization into puncta-like clusters upon ER depletion in mouse hippocampal and cortical neurons."
25964739
CACNA1C affects CACNA1D, and MAP2B
| 1
CACNA1C binds CACNA1D and MAP2B. 1 / 1
| 1
sparser
"The neuronal AKAP MAP2B, which also interacts with CaV1.2 and CaV1.3 channels, has complementary localization to AKAP15, suggesting different functional roles in calcium channel regulation."
21224388
CACNA1C affects BrS9
| 1
CACNA1C activates BrS9. 1 / 1
| 1
reach
"Mutations in CACNA1C, CACNB2 and CACNA2D1 can cause BrS3, BrS4 and BrS9, respectively [96,97]."
30027834
CACNA1C affects BMP
| 1
CACNA1C activates BMP. 1 / 1
| 1
reach
"2 CACNA1C modulates BMP signaling in the hair follicle 5, RhoA in neurons 6, and calcineurin-NFAT in chondrocytes 7."
25900989
CACNA1C affects BDNF
| 1
BDNF binds CACNA1C. 1 / 1
| 1
sparser
"Examination of BRAINEAC data showed that human risk-associated genetic variation in CACNA1C is also associated with altered expression of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex in humans."
30304534
CACNA1C affects BB4
| 1
CACNA1C activates BB4. 1 / 1
| 1
reach
"Mutations in CACNA1C, CACNB2 and CACNA2D1 can cause BrS3, BrS4 and BrS9, respectively [96,97]."
30027834
CACNA1C affects Akap5
| 1
CACNA1C binds Akap5. 1 / 1
| 1
sparser
"In this model, the anchoring protein AKAP150 and Ca V 1.2-LQT8 form a complex that is necessary for aberrant Ca V 1.2-LQT8 channel gating and arrhythmias."
21700933
CACNA1C affects Akap1
| 1
CACNA1C binds Akap1. 1 / 1
| 1
sparser
"CaV1.2 is associated with AKAP at rest [ xref ], whereas for CRAC channels, the association is induced after store depletion [ xref ]."
27377718
CACNA1C affects ATP2A2
| 1
CACNA1C binds ATP2A2. 1 / 1
| 1
reach
"Our data show that the mouse orthologs for ATP2A2 and SRL both interact with CAV3, and that ATP2A2 also interacts with the LQTS calcium channel CACNA1C."
24952909
CACNA1C affects ATP
| 1
CACNA1C increases the amount of ATP. 1 / 1
| 1
reach
"In line with the previous findings on mitochondrial morphology, the downregulation of Cacna1c blocked the loss of ATP levels in response to glutamate."
29760952
CACNA1C affects APP
| 1
CACNA1C binds APP. 1 / 1
| 1
reach
"However, the relative interactions between miR-137, p-tau, CACNA1C, and Abeta, and the regulatory effect of miR-137 on the progression of AD in vivo require further investigation."
30102687
CACNA1C affects AKAP7
| 1 1
CACNA1C binds AKAP7. 1 / 1
| 1 1
sparser
"Studies with mice that lack the distal C-terminal domain of CaV1.2 channels (CaV1.2ΔDCT) reveal that AKAP15 interacts with neuronal CaV1.2 channels via their C terminus in vivo and is co-localized in punctate clusters of CaV1.2 channels via that interaction."
21224388
CACNA1C affects ADCY3
| 1
CACNA1C binds ADCY3. 1 / 1
| 1
reach
"41 Perhaps most interesting is that ADCY and GAL activity are inter related 42 and ADCY3 binds CACNA1C (calcium channel, voltage dependent, L type, alpha-1C subunit)."
21042317
CACNA1A affects CACNA1C, DBP, and SBP
| 1
CACNA1A binds CACNA1C, DBP, and SBP. 1 / 1
| 1
sparser
"In the gene-based analysis, CACNA1A and CACNA1C were significantly associated with DBP change (P = 2.0×10 -5 ) and SBP change (P = 1.4×10 -4 ) after Bonferroni correction, respectively."
27418245
CACNA1A affects CACNA1B, CACNA1C, and Calcium_channels
| 1
Calcium_channels binds CACNA1A, CACNA1B, and CACNA1C. 1 / 1
| 1
sparser
"For instance, association of several voltage-dependent calcium channel genes such as CACNA1C and CACNA1B was reported in large-scale GWAS for BD. xref , xref A pathway analysis of GWAS data suggests enrichment of calcium channel-related pathways among the genes empirically associated with BD. xref Studies of peripheral blood cells have consistently demonstrated altered intracellular calcium signaling in BD. xref , xref Lithium, the first-line therapeutic drug for BD, modulates inositol-mediated pathways xref and thereby regulate calcium ion release from the endoplasmic reticulum. xref When we performed a GO enrichment analysis using DAVID xref , xref by integrating the data of de novo protein-altering mutations in our study, common single-nucleotide polymorphisms associated with BD in a large-scale GWAS xref and rare CNVs implicated in BD xref (total no. of unique input genes=229, see xref for details), ‘calcium signaling pathway (hsa04020)' was the only term significantly enriched after performing correction for multiple testing ( P corrected =6.4 × 10 −3 , Bonferroni correction; note that significant enrichment of ‘calcium signaling pathway (hsa04020)' after correction was not observed when we submitted candidate genes from each study)."
27217147
BRS3 affects CACNA1C
| 1
BRS3 binds CACNA1C. 1 / 1
| 1
sparser
"BrS3 is associated with mutations in CACNA1C (see Table xref )."
23874304
BP affects CACNA1C, and Calcium_channels
| 1
Calcium_channels binds CACNA1C and BP. 1 / 1
| 1
sparser
"Allelic variation at CACNA1C has been associated with BP response to calcium channel blockers ( xref , xref ), or even BP itself ( xref )."
22676942
BDNF affects CACNA1C
| 1
BDNF binds CACNA1C. 1 / 1
| 1
sparser
"Examination of BRAINEAC data showed that human risk-associated genetic variation in CACNA1C is also associated with altered expression of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex in humans."
30304534
Akap5 affects CACNA1C
| 1
CACNA1C binds Akap5. 1 / 1
| 1
sparser
"In this model, the anchoring protein AKAP150 and Ca V 1.2-LQT8 form a complex that is necessary for aberrant Ca V 1.2-LQT8 channel gating and arrhythmias."
21700933
Akap1 affects CACNA1C
| 1
CACNA1C binds Akap1. 1 / 1
| 1
sparser
"CaV1.2 is associated with AKAP at rest [ xref ], whereas for CRAC channels, the association is induced after store depletion [ xref ]."
27377718
Abeta peptides affects CACNA1C
| 1
Abeta peptides activates CACNA1C. 1 / 1
| 1
reach
"The upregulation of CACNA1C caused by Abeta peptides has also been previously shown to be associated with AD risk in vitro [XREF_BIBR]."
30102687
ATP2A2 affects CACNA1C
| 1
CACNA1C binds ATP2A2. 1 / 1
| 1
reach
"Our data show that the mouse orthologs for ATP2A2 and SRL both interact with CAV3, and that ATP2A2 also interacts with the LQTS calcium channel CACNA1C."
24952909
ATP1B1 affects CACNA1C, CAV3, KCNH2, and KCNQ1
| 1
CACNA1C binds CAV3, KCNH2, KCNQ1, and ATP1B1. 1 / 1
| 1
sparser
"We showed that ATP1B1 interacts with KCNH2, CACNA1C, KCNQ1and CAV3."
24952909
ASGR1 affects CACNA1C
| 1
ASGR1 inhibits CACNA1C. 1 / 1
| 1
reach
"miR-29 over-expression in HL1 atrial cardiomyocyte deregulate Cacna1c, Hnc4 and Ryr2, influencing therefore both the calcium handling and pacemaker activity, whereas miR-200 regulated Cacna1c, Ryr2 and Camk2a, in addition to Scn5a as previously reported [XREF_BIBR], impacting therefore also in calcium handling."
29194452
APP affects CACNA1C
| 1
CACNA1C binds APP. 1 / 1
| 1
reach
"However, the relative interactions between miR-137, p-tau, CACNA1C, and Abeta, and the regulatory effect of miR-137 on the progression of AD in vivo require further investigation."
30102687
ANK3 affects CACNA1C, and ITIH3
| 1
CACNA1C binds ANK3 and ITIH3. 1 / 1
| 1
sparser
"When applied in BPD, systems biology revealed the implication of a number of genes including interactions of CACNA1C, ANK3, and ITIH3-4 genes via genetic association analysis."
23269912
ANK3 affects CACNA1C, and EGFR
| 1
CACNA1C binds EGFR and ANK3. 1 / 1
| 1
sparser
"While we could not confirm an association of ANK3, CACNA1C, and EGFR with BPD, 10 SNPs in DGKH, CMTM8, and NPAS3 were nominally associated with disease, with two DGKH markers surviving correction for multiple testing."
21654738
ANK3 affects CACNA1C, CMTM8, DGKH, and EGFR
| 1
CACNA1C binds CMTM8, DGKH, EGFR, and ANK3. 1 / 1
| 1
sparser
"To address these issues, we genotyped SNPs in ANK3, CACNA1C, CMTM8, DGKH, EGFR, and NPAS3, which were significantly associated with BPD in previous GWAS, in a sample of 380 BPD patients."
21654738
ANK2 affects CACNA1C, CTNNA3, PKP2, SCN10A, and USP9X
| 1
SCN10A binds USP9X, CACNA1C, CTNNA3, ANK2, and PKP2. 1 / 1
| 1
sparser
"To our knowledge, this is the first report of association of the CACNA1C, CTNNA3, PKP2, ANK2 and SCN10A genes with FAF; it is also the first study in Russian families."
31539150
AKAP7 affects CACNA1C
| 1 1
CACNA1C binds AKAP7. 1 / 1
| 1 1
sparser
"Studies with mice that lack the distal C-terminal domain of CaV1.2 channels (CaV1.2ΔDCT) reveal that AKAP15 interacts with neuronal CaV1.2 channels via their C terminus in vivo and is co-localized in punctate clusters of CaV1.2 channels via that interaction."
21224388
ADCY3 affects CACNA1C
| 1
CACNA1C binds ADCY3. 1 / 1
| 1
reach
"41 Perhaps most interesting is that ADCY and GAL activity are inter related 42 and ADCY3 binds CACNA1C (calcium channel, voltage dependent, L type, alpha-1C subunit)."
21042317
ABL1 affects AS1, CACNA1C, HAND2, SLC2A4, and ZFPM2
| 1
SLC2A4 binds CACNA1C, ZFPM2, HAND2, ABL1, and AS1. 1 / 1
| 1
sparser
"For example, HAND2-AS1 interacted with SLC2A4, ZFPM2, CACNA1C and ABL1 mediated by mir-93, mir-141, mir-133a-1 and mir-30a, respectively (Figure xref )."
27863388
A allele affects CACNA1C
| 1
A allele activates CACNA1C. 1 / 1
| 1
reach
"Although this has yet to be confirmed, data from post-mortem brain tissue indicate that carriers of the A allele have increased CACNA1C mRNA production in the CNS."
22290120
3',5'-cyclic AMP affects CACNA1C
| 1
3',5'-cyclic AMP phosphorylates CACNA1C. 1 / 1
| 1
reach
"CAMP kinase, cGMP kinase, protein kinase C, calmodulin kinase II and casein kinase II phosphorylated the 165-kDa and the 55-kDa proteins of the purified CaCB receptor."
2850184
CACNA1C affects calcium(2+), and calcium(2+)
|
CACNA1C catalyzes the conversion of calcium(2+) into calcium(2+). 2 / 2
2 |
biopax:panther
No evidence text available
biopax:panther
No evidence text available