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phosphosite cbn pc11 biopax bel_lc signor biogrid lincs_drug tas hprd trrust ctd virhostnet phosphoelm drugbank omnipath | geneways tees isi trips rlimsp medscan sparser eidos reach
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DPYSL2 affects CACNA1B
| 2 102
| 2 86
sparser
"To develop a reagent to disrupt the interaction of CRMP-2 with the CaV2.2 complex in vivo , we synthesized a series of overlapping 15-amino-acid peptides covering the entire length of CRMP-2, including three CaV binding domains (CBDs1–3) we had previously identified in vitro as crucial for the CRMP-2CaV2.2 interaction xref ."
sparser
"Second , despite being an indirect ‘blocker’ of Ca 2+ influx, ( S )-LCM provides improved efficacy compared to TROX-1, a small-molecule, state-dependent blocker of CaV2 channels [ xref ] as well as a membrane-tethered CRMP2 peptide that uncouples the CRMP2-CaV2.2 interaction that we recently reported [ xref ]."
sparser
"The CRMP2CaV2.2 interaction was dynamic as potassium chloride-induced depolarization led to an increase in the interaction."
sparser
"We previously showed that tat-CBD3 inhibited the CaV2.2CRMP2 interaction. xref Therefore, we next tested whether the myristoylated CBD3 peptide could interfere with the CaV2.2CRMP2 interaction."
sparser
"We determined that CRMP-2 interacts with CaV2.2 and that overexpression of CRMP-2 leads to increased surface expression of CaV2.2 and enhanced Ca 2+ currents xref , xref ."
sparser
"Pull-down studies demonstrated that myr-tat-CBD3 peptide interfered with the CRMP2CaV2.2 interaction."
sparser
"Although the control peptides did not alter this interaction, the tat-CBD3 peptide was able to inhibit CaV2.2CRMP2 interaction by ~43% at 10 μM. Myr-tat-CBD3, in a concentration-dependent manner, attenuated this interaction with greater than ~81% inhibition at 10 μM ( xref ; top blot and xref )."
sparser
"ST1-104, which disrupts the interaction between CaV2.2 and CRMP2 interaction, reduces persistent mechanical hypersensitivity induced by systemic administration of ddC [ xref ]."
sparser
"Co-immunoprecipitation experiments showed that CRMP-2 associates with Cav2.2 from DRG lysates."
sparser
"As CBD3 disrupts the interaction between CRMP2 and CaV2.2, this supports the conclusion that the interaction between CRMP2 and CaV2.2 is likely responsible for the observed increase in Ca 2+ currents."
sparser
"Thus, in vitro , CBD3 disrupts the CRMP-2-CaV2.2 interaction and affects CaV2.2 trafficking and Ca 2+ current density."
sparser
"In addition, more recent studies have reported that CRMP-2 can bind to the voltage-gated calcium channel Cav2.2, and this interaction may play a crucial role in neurotransmitter release from the presynaptic terminals of hippocampal neurons ( xref )."
sparser
"Competition between syntaxin 1A and neurofibromin for a singular CRMP2 binding domain regulates CRMP2’s direct interaction with Cav2.2."
sparser
"The pharmacological action of peptides observed in our in vitro experiments is linked to uncoupling of the CaV2.2CRMP2 interaction culminating in alleviation of inflammatory and neuropathic pain. xref , xref , xref , xref , xref Sustained, but incomplete, relief of neuropathic pain has been successfully demonstrated for a nonmyristoylated CRMP2 peptide. xref We postulate that the myristoylated version described herein may afford greater efficacy and clinical utility as a gene therapy strategy for chronic pain."
sparser
"The functional consequence of the disrupted CaV2.2CRMP2 interaction was a significantly higher extent (i.e. efficacy) of inhibition of calcium influx in sensory neurons."
sparser
"Finally, to confirm the disruption of CRMP2 interaction with Cav2.2 in sensory neurons, we used a PLA."
sparser
"Here, we report ST2-104 –a peptide wherein the cell-penetrating TAT motif has been supplanted with a homopolyarginine motif, which dose-dependently inhibits the CaV2.2CRMP2 interaction and inhibits depolarization-evoked Ca 2+ influx in sensory neurons."
sparser
"These findings suggest that the biochemical interaction between CRMP-2 and CaV2.2 is required for proper channel trafficking and function."
sparser
"These results demonstrate that by uncoupling the CaV2.2CRMP2 interaction, both tat-CBD3 and myr-tat-CBD3 reduce surface trafficking of CaV2.2 (eg, 0.60 PCC and 0.65 MOC for the myr-tat-CBD3-treated DRG as noted by the lack of colocalization in the insets)."
sparser
"We previously showed that CRMP2 is a novel binding partner of CaV2.2. xref , xref A 15-amino acid peptide derived from CRMP2 (designated CBD3 for calcium channel binding domain) uncoupled the CaV2.2CRMP2 interaction leading to a decrement in Ca 2+ current and neurotransmitter release and, consequently, suppressed persistent inflammatory and neuropathic hypersensitivity. xref , xref , xref Mutating single residues within the CBD3 peptide sequence or changing the cell-penetrating motif improved the efficacy of CBD3 in models of neuropathic pain. xref , xref Here, we tested the hypothesis that tethering the CBD3 peptide to the membrane with myristate would confine the myristoylated peptide’s action(s) to uncoupling membrane CaV2.2CRMP2 interactions, block Ca 2+ influx in sensory neurons, and be effective in reducing pain-related behaviors in models of pain."
sparser
"Similar to TAT-conjugated CBD3 (designated ST1-104), the R9-conjugated CBD3 (designated ST2-104) peptide interfered with the CaV2.2CRMP2 interaction."
sparser
"N-myristate-tat-CBD3 peptide inhibits the CaV2.2CRMP2 interaction."
sparser
"We report that myristoylated tat-CBD3 is membrane tethered, restricts the CaV2.2CRMP2 interaction, blocks CaV2.2 trafficking, and strongly inhibits Ca 2+ influx from primary sensory neurons."
sparser
"These results demonstrate that the myristoyl group improves the ability of the peptide to break the CaV2.2CRMP2 interaction."
sparser
"A homopolyarginine (R9)-conjugated CBD3-A6K (R9-CBD3-A6K) peptide inhibited the CaV2.2-CRMP2 interaction in a concentration-dependent fashion and diminished surface expression of CaV2.2 and depolarization-evoked Ca influx in rat dorsal root ganglia neurons."
sparser
"These results demonstrate that the R9-conjugated mutant peptide retains its ability to efficiently uncouple the CRMP2CaV2.2 interaction."
sparser
"Interference of the protein-protein interaction between the target collapsin response mediator protein 2 (CRMP2) and CaV2.2 in sensory neurons by unique peptides effectively diminishes trafficking of the ion channel to the plasma membrane and serves to attenuate peripheral sensitization in rodent models of inflammation or neuropathic pain ( xref , xref , xref , xref , xref )."
sparser
"We tested the hypothesis that replacement of the TAT motif with the presumably superior cell penetrating prowess of the homopolyarginine motif ( xref ) would prevent CRMP2CaV2.2 interaction, block Ca 2+ influx in sensory neurons, and be effective in reducing pain-related behavior in various models of peripheral neuropathy."
sparser
"We reported that collapsin response mediator protein 2 (CRMP2) interacts with CaV2.2 and enhances its functional activity [ xref ; xref ; xref ; xref ]."
sparser
"Data here demonstrate a novel efficacious compound to inhibit pain without demonstrating any addiction or motor deficits ( xref , xref ) providing an instructive example of how designing peptides tailored to limit membrane CaV2.2CRMP2 interactions can have a great utility in the treatment of post-surgical and inflammatory pain."
sparser
"In rat DRGs, only CBD3’s N-terminal fragment successfully inhibited depolarization-evoked calcium influx, reduced Ca 2+ currents, and disrupted the CRMP2-Cav2.2 interaction in situ [ xref ]."
sparser
"We first tested if the nona-arginine (R9) motif conjugated to the CBD3 peptide of CRMP2, designated ST2-104 peptide, could interfere with the CaV2.2CRMP2 interaction."
sparser
"Over the last few years, we have described an interaction between CaV2.2 and tetrameric collapsin response mediator protein 2 (CRMP-2) that positively regulates channel function by increasing cell surface trafficking [ xref , xref , xref ]."
sparser
"The functional consequence of the disrupted CaV2.2CRMP2 interaction was a significantly higher extent (i.e. efficacy) of inhibition of calcium influx in sensory neurons."
sparser
"Probing of the CRMP2-enriched fraction with a CaV2.2 antibody demonstrated a robust interaction between CaV2.2 and CRMP2 ( xref ; top blot, lanes 1, 2 ) whereas a glutathione beads only pull-down did not capture any CaV2.2 ( xref ; top blot, lane 7 )."
sparser
"Disruption of the interaction between CaV2.2 and CRMP2 by a short peptide (CBD3) corresponding to a 15 amino acid region of CRMP-2 produces a number of changes including pain signal transmission [ xref ]."
sparser
"A search for small molecules that could recapitulate uncoupling of the CaV2.2-CRMP2 interaction identified (S)-lacosamide [(S)-LCM], the inactive enantiomer of the Food and Drug Administration-approved antiepileptic drug (R)-lacosamide [(R)-LCM, Vimpat]."
sparser
"Importantly, disrupting the CRMP2-Cav2.2 interaction did not alter core sympathetic nervous system functions such as pulsatile arterial pressure, mean arterial pressure, heart rate, and core body temperature [ xref ]."
sparser
"We reported that Cdk5-mediated CRMP2 phosphorylation increases its binding to CaV2.2, which augments calcium influx xref ; thus, the increased interaction between CRMP2 and CaV2.2 may underlie the mechanism of antinociception in this particular model."
sparser
"Systemic administration of ( S )-LCM to mice, at three daily doses of 20 mg/kg over four days, successfully uncoupled the CRMP2-Cav2.2 interaction in brain lysates, with no detectable effects on locomotion, feeding, or behavior [ xref ]."
sparser
"Towards this end, we recently identified a short peptide, designated CBD3, derived from collapsin response mediator protein 2 (CRMP-2) that suppressed inflammatory and neuropathic hypersensitivity by inhibiting CRMP-2 binding to CaV2.2 [Brittain et al ., Nature Medicine 17:822–829 (2011)]."
sparser
"Reasoning that the reported superior cell penetrating ability of the nona-arginine CPP ( xref ) may allow for greater uptake of the peptide which may result in superior biochemical and functional uncoupling of the CaV2.2CRMP2 interaction and suppression of transmitter release from nociceptive neurons culminating in efficacy in chronic pain models, we tested the R9 grafted CBD3 (i.e. ST2-104) peptide in the TNI model of traumatic neuropathy."
sparser
"These results suggest a coordinated mechanism involving interactions between CRMP2 and CaV2.2 to facilitate the release of pro-nociceptive CGRP that consequently leads to cephalic pain."
sparser
"This value is in agreement with an IC 50 value of ~2.8 µM for inhibition of Ca 2+ influx for a membrane-tethered CRMP2 peptide that uncouples the CRMP2-CaV2.2 interaction that we recently reported [ xref ]."
sparser
"These findings suggest that the biochemical interaction between CRMP-2 and CaV2.2 is required for proper channel trafficking and function."
sparser
"The interaction between CaV2.2 and CRMP2 can be disrupted by a short peptide (CBD3) corresponding to a 15 amino acid region of CRMP-2 ( xref )."
sparser
"The study of CaV2.2 trafficking modulators xref led us to identify axon/dendrite specification collapsin response mediator protein 2 (CRMP2) as a CaV2.2-binding partner, xref which enhances CaV2.2 membrane trafficking and facilitates synaptic transmission. xref , xref CaV2.2 membrane trafficking was effectively disrupted by a 15-amino-acid region of CRMP2, named Ca 2+ channel-binding domain 3 (CBD3). xref Systemic injection of CBD3 peptide conjugated to the cell-penetrating motif of the HIV transduction domain protein tat (tat-CBD3) reduced hypersensitive behavior in chemically induced inflammatory and neuropathic pain models. xref , xref , xref , xref tat-CBD3 reduced CaV2.2-mediated currents by inhibiting CaV2.2CRMP2 interaction, xref which resulted in reduced nociceptor excitability, diminished neuropeptide release from primary sensory neurons, and lowered excitatory synaptic transmission. xref "
sparser
"In parallel, it was discovered that phosphorylation of CRMP2 by Cdk5 dynamically regulates and increases the association of CRMP2 with Cav2.2 [ xref ]."
sparser
"Here we report suppression of both inflammatory and neuropathic hypersensitivity by inhibiting the binding of the axonal collapsin response mediator protein 2 (CRMP-2) to CaV2.2, thus reducing channel function."
sparser
"Having established that both peptides can inhibit the CaV2.2CRMP2 interaction in vitro, we next asked whether this translated into a disruption in cells."
sparser
"A screening protocol of >50 novel molecules unexpectedly identified the small molecule ( S )-lacosamide (( S )-LCM) xref as a novel inhibitor of CRMP2 interactions with CaV2.2."
sparser
"We previously showed that all cell penetrant forms of CBD3 inhibited the CRMP2CaV2.2 interaction [ xref ; xref ; xref ; xref ]."
sparser
"We determined that CRMP-2 interacts with CaV2.2 and that overexpression of CRMP-2 leads to increased surface expression of CaV2.2 and enhanced Ca 2+ currents [ xref , xref , xref ]."
sparser
"Similar to TAT-CBD, the R9-conjugated CBD3 peptide interfered with the CaV2.2CRMP2 interaction."
sparser
"Probing of the CRMP2-enriched fraction with a Cav2.2 antibody demonstrated a robust interaction between Cav2.2 and CRMP2 ( xref ; top blot, lane 2 )."
sparser
"In a series of studies examining targets of synthetic CBD peptides, conjugated to the HIV1 TAT (t−) domain for cell penetrance, only t-CBD3, comprised of CRMP2 residues 484-498, succeeded in biochemically inhibiting the CRMP2-Cav2.2 interaction [ xref ]."
sparser
"CRMP-2 binds directly to CaV2.2 in two regions: the channel domain I-II intracellular loop and the distal C terminus."
sparser
"Thus, we used immunofluorescent microscopy to determine the time course of CBD3-mediated disruption of the CaV2.2CRMP2 interaction."
sparser
"The authors’ results demonstrated that a direct interaction between CRMP2 and CaV2.2 increases cell surface trafficking of CaV2.2 as well as calcium current density, which leads not only to an increased release of the neurotransmitter glutamate and synaptic vesicle recycling but also impacts axonal growth of hippocampal neurons."
sparser
"Although CBD3 has been previously demonstrated to interfere with the CaV2.2CRMP2 interaction, the dynamics of the disruption over time by this peptide have never been studied."
sparser
"Probing of the CRMP2-enriched fraction with a CaV2.2 antibody demonstrated a robust interaction between CaV2.2 and CRMP2 ( xref ; top blot, lane 2 )."
sparser
"We show that ST2-104 interferes with the CaV2.2CRMP2 interaction and inhibits Ca 2+ influx from sensory neurons."
sparser
"These findings suggested that the biochemical interaction between CRMP2 and CaV2.2 was required for proper channel trafficking and function."
sparser
"These findings are entirely consistent with our previous results demonstrating longer periods of pain-related behavior reversal in the TNI versus the ddC model following systemic injection of a TAT-conjugated peptide from calcium channels that breaks the CaV2.2CRMP2 interaction ( xref ) as well as with the CRMP2-derived ST1-104 peptide ( xref )."
sparser
"While activation of Cdk5 and increased CRMP2 expression in rat DRGs contribute to several pain phenotypes, ( S )-LCM biochemically disrupts the CRMP2-Cav2.2 interaction while inhibiting depolarization-evoked Ca 2+ influx and Ca 2+ currents [ xref , xref , xref – xref ]."
sparser
"Thus, our results indicate that using TAT-CBD3 which interferes with CaV2.2 and CRMP-2 interactions can reduce inflammatory and neuropathic pain behaviors."
sparser
"Lastly, we utilized the recently developed peptide myr-TAT-CBD3 to disrupt the interaction between CRMP2 and CaV2.2 in vivo."
sparser
"Although the precise nature of NF1-linked pain syndromes remains unknown, patients clearly experience pain independent of their tumor burden, and these findings affirm the necessity of CRMP2 in NF1-related pain, while suggesting a physiological role for neurofibromin’s C-terminal domain-mediated inhibition of the CRMP2-Cav2.2 interaction [ xref ]."
sparser
"We tested the hypothesis ( xref ) that uncoupling the CRMP-2CaV2.2 interaction would lead to a physiologically relevant decrease in Ca 2+ current and neurotransmitter release and, in turn, suppress persistent inflammatory and neuropathic hypersensitivity."
sparser
"The present findings make a compelling case for the use of a myristoylated CRMP2 peptide, which uncouples the CaV2.2CRMP2 interaction, for the treatment of inflammatory and incision-induced pain."
sparser
"Immunoprecipitations from spinal cord lysates demonstrated that CBD3 peptide inhibited the interaction between CRMP-2 and CaV2.2 ( xref ; top, middle ) but did not affect the interaction between tubulin and CRMP-2 xref ( xref , bottom )."
sparser
"Peptides uncoupling CaV2.2 interactions with the axonal collapsin response mediator protein 2 (CRMP2) were antinociceptive without effects on memory, depression, and reward/addiction."
sparser
"Here, we investigated the effects of a functional association of CRMP-2 with Cav2.2 in sensory neurons."
sparser
"Interestingly, in this animal model of pain, the peptide is administered systemically after the development of chronic hypersensitivity and is still able to effectively attenuate nociceptive behaviors, suggesting a continued role for the interaction of CRMP-2 and CaV2.2 on neurotransmitter release."
sparser
"Here we report that inflammatory and neuropathic hypersensitivity can be suppressed by inhibiting the binding of collapsin response mediator protein 2 (CRMP-2) to CaV2.2 and thereby reducing channel function."
sparser
"Concomitant expression of CaV2.2, CRMP2, and CGRP was detected in a subset of neurons from the ophthalmic branch of TGs that receive input from the dura mater. xref These results suggest a coordinated mechanism involving interactions between CRMP2 and CaV2.2 to facilitate the release of pro-nociceptive CGRP that consequently leads to cephalic pain."
sparser
"We previously reported that CBD3, a 15 amino acid fragment of CRMP2, disrupts the CRMP2CaV2.2 interaction [ xref ] irrespective of the cell penetrating motif it is appended to: the HIV-1 transactivator of transcription domain (TAT) [ xref ], a myristate (Myr) tag [ xref ], or homopolyarginine (R9) [ xref ]."
sparser
"Binding affinity of Ct-Cav2.2/CRMP2 was ~75 fold greater than between L1-Cav2.2/CRMP2, and only disruption of the Ct-Cav2.2/CRMP2 interaction inhibited evoked CGRP release in rat DRGs [ xref ]."
sparser
"As previously described, CaV2.2CRMP2 disruption by tat-CBD3 decreased surface CaV2.2 in DRG. xref , xref Myr-tat-CBD3 peptide interfered with the CaV2.2CRMP2 interaction more efficiently than tat-CBD3 as observed by a reduction in colocalization within minutes of incubation ( xref )."
sparser
"TAT-CBD3 peptide interfered with CRMP2-CaV2.2 interactions resulting in acute inhibition of CaV2.2 currents in sensory and hippocampal neurons; acute inhibition of frequency of spontaneous excitatory postsynaptic currents (sEPSCs) in spinal cord slices as well as layer V pyramidal neurons suggesting reduction in probability of glutamate release from stimulated presynaptic terminals; and inhibition of evoked calcitonin gene-related peptide (CGRP) in sensory neurons in culture (acute and long-term inhibition observed) and in spinal cord slices."
sparser
"We reasoned that by uncoupling the interaction between CaV2.2 and CRMP-2 within primary afferent sensory neurons, we would be able to mimic the inhibition of neurotransmitter release observed with siRNA knockdown of CRMP-2."
sparser
"Our initial mapping of the CaV2.2:CRMP2 interaction had identified a surface-exposed region in CRMP2, which we designated calcium channel binding domain 3 (CBD3) [ xref ]."
sparser
"We previously identified ST1-104, a short peptide from the collapsin response mediator protein 2 (CRMP2), which disrupted the CaV2.2CRMP2 interaction and suppressed a model of HIV-related neuropathy induced by antiretroviral therapy but not traumatic neuropathy."
sparser
"From these findings, we propose that TAT-CBD3 allows suppression of pain hypersensitivity without directly blocking CaV2.2, but rather by inhibiting the binding of a regulator of CaV2.2 function, CRMP-2."
sparser
"Probing of the CRMP2-enriched fraction with a CaV2.2 antibody demonstrated a robust interaction between CaV2.2 and CRMP2 ( xref ; top blot, lane 2)."
sparser
"R9-CBD3-A6K disrupts the CRMP2CaV2.2 interaction and inhibits surface trafficking of CaV2.2 in DRGs."
| 4
sparser
"In this platform, neurofibromin interacts with CRMP2 to prevent recruitment of syntaxin 1A and CaV2.2, thus leading to block of CGRP and a reduction in pain behaviors."
sparser
"Our work also identifies a novel tool–the CRMP2-derived aptamer CNRP, which is capable of uncoupling CRMP2’s interactions with neurofibromin, syntaxin 1A, and Cav2.2."
sparser
"We previously found that this peptide inhibited CRMP2’s interaction with CaV2.2, neurofibromin, and syntaxin 1A. A cell-penetrant version of this peptide (t-CNRP1) inhibited CaV2.2 and NaV1.7 currents in Nf1 -edited neurons."
sparser
"These results suggest that targeting CRMP2 interactions with neurofibromin, syntaxin 1A and Cav2.2 is beneficial for nociceptive pain behaviors in a rat model of HIV-SN."
| 3
sparser
"Neurons treated with tat-CRMP2/neurofibromin regulating peptide 1 (t-CNRP1) exhibited a decreased Cav2.2 membrane localization, and uncoupling of neurofibrominCRMP2 and CRMP2Cav2.2 interactions."
sparser
"Collectively, these results demonstrate that t-CNRP1 decreases Cav2.2-dependent Ca 2+ influx, currents, and surface localization through disruption of CRMP2’s binding to Cav2.2 and neurofibromin."
sparser
"Our goal was to identify the component(s) of the CRMP2neurofibromin interaction that regulate Cav2.2 activity."
| 3
sparser
"We previously reported that uncoupling the CaV2.2CRMP2 interaction with TAT- [ xref ] or R9-CBD3 [ xref ] resulted in a reduction of depolarization-induced Ca 2+ -influx in sensory neurons."
sparser
"To determine if perturbing the CRMP-2CaV2.2 interaction with the TAT-CBD3 peptide can modulate transmitter release, resting and potassium-stimulated release of immunoreactive CGRP (iCGRP) was measured from supernatants of DRG neurons in culture that were treated with 10 μM TAT-CBD3 or TAT scramble."
sparser
"We previously reported that uncoupling the CaV2.2CRMP2 interaction with tat-CBD3 resulted in reduction of depolarization-induced Ca 2+ -influx in sensory neurons. xref Here, we asked whether the myr-tat-CBD3 peptide could work similarly."
| 2
sparser
"We propose that CNRP1 uncouples CRMP2’s interactions with Cav2.2 and syntaxin 1A, resulting in Cav2.2 relocalization away from the plasma membrane; decreased synaptic vesicle docking to the Ca 2+ channel; and consequently, decreased CGRP release."
sparser
"However, loss of neurofibromin, as observed in NF1 patients, results in disinhibition of the tripartite CRMP2-Cav2.2-syntaxin 1A interaction, therefore permitting increased N-type Ca 2+ currents and CGRP release."
sparser
"A recently discovered interaction between the N-type calcium channel, CaV2.2 and collapsin response mediator protein 2 (CRMP-2) positively regulated channel functions by increasing CaV2.2’s cell surface trafficking [ xref - xref ]."
CACNA1B binds DPYSL2 and DRG. 1 / 1
| 1
sparser
"Direct protein interactions between CRMP2 and Cav2.2 in DRG sensory neurons were evident with PLA ( xref )."
| 1
sparser
"We previously reported that uncoupling the CaV2.2CRMP2 interaction with ST1-104 resulted in reduction of depolarization-induced Ca 2+ -influx in sensory neurons ( xref )."
sparser
"We have demonstrated that interfering with the CaV2.2CRMP2 interaction with TAT-conjugated CBD3-scaffold peptides ST1-104, ST1-106, and ST1-107 mitigates inflammatory and neuropathic pain ( xref , xref , xref , xref )."
14 | 1
| 1
reach
"Transient expression in cultured skeletal muscle myotubes derived from muscular dysgenic mice demonstrates that the BIII channel mediates an omega-conotoxin-sensitive calcium current with kinetics and voltage dependence like those previously reported for whole-cell N-type current."
STX1A affects CACNA1B
| 11
| 5
sparser
"Past efforts to harness uncoupling of the syntaxin 1A-Cav2.2 interaction for therapeutic use have not advanced despite an early report of success [ xref ]."
sparser
"Neurofibromin sequesters CRMP2 from syntaxin 1A. On loss of neurofibromin, as observed in patients with NF1, the CRMP2/neurofibromin interaction is uncoupled, which liberates CRMP2 to interact with both syntaxin 1A and Cav2.2, culminating in increased release of the pronociceptive neurotransmitter CGRP."
sparser
"Interactions between Cav2.2 and the synaptic protein syntaxin 1A then follow to produce fast, synchronous neurotransmitter release [ xref – xref ]."
sparser
"Neurofibromin uncouples CRMP2 from syntaxin 1A. Upon loss/mutation of neurofibromin, as seen in patients with NF1, the CRMP2/Neurofibromin interaction is uncoupled, which frees CRMP2 to interact with both syntaxin 1A and CaV2.2, culminating in increased release of the pro-nociceptive neurotransmitter calcitonin gene related peptide (CGRP)."
sparser
"In the DII-DIII linker, PKC phosphorylates the sites identified in mouse brain as S773 and S892, and CaMKII at S783, and impacts syntaxin1ACav2.2 interaction ( xref )."
| 4
sparser
"In this platform, neurofibromin interacts with CRMP2 to prevent recruitment of syntaxin 1A and CaV2.2, thus leading to block of CGRP and a reduction in pain behaviors."
sparser
"Our work also identifies a novel tool–the CRMP2-derived aptamer CNRP, which is capable of uncoupling CRMP2’s interactions with neurofibromin, syntaxin 1A, and Cav2.2."
sparser
"We previously found that this peptide inhibited CRMP2’s interaction with CaV2.2, neurofibromin, and syntaxin 1A. A cell-penetrant version of this peptide (t-CNRP1) inhibited CaV2.2 and NaV1.7 currents in Nf1 -edited neurons."
sparser
"These results suggest that targeting CRMP2 interactions with neurofibromin, syntaxin 1A and Cav2.2 is beneficial for nociceptive pain behaviors in a rat model of HIV-SN."
| 2
sparser
"We propose that CNRP1 uncouples CRMP2’s interactions with Cav2.2 and syntaxin 1A, resulting in Cav2.2 relocalization away from the plasma membrane; decreased synaptic vesicle docking to the Ca 2+ channel; and consequently, decreased CGRP release."
sparser
"However, loss of neurofibromin, as observed in NF1 patients, results in disinhibition of the tripartite CRMP2-Cav2.2-syntaxin 1A interaction, therefore permitting increased N-type Ca 2+ currents and CGRP release."
CACNA1B affects BI
| 6
CACNA1B binds BI. 5 / 5
| 5
sparser
"We also used quasielastic light scattering to demonstrate that the BI and BIII alpha-helix formation in 0.2 M Ca(ClO4)2 is accompanied by formation of trimers and hexamers, respectively."
sparser
"In this paper, we examine the effects of electrostatic and hydrophobic interactions that control folding of BI and BIII by systematically monitoring their secondary structures as a function of solution conditions."
sparser
"The His residue has a pK a of ∼6 and does not appear to play a role in BI and BIII α -helix formation."
sparser
"Repair cells at the cut edge lead the lens epithelium off the lens capsule onto and across the rigid tissue culture substrate, referred to the extracapsular zone (ECZ). (BiBiii) Representative still images from a time-lapse movie (Supplemental Video 1) taken over 3 d postinjury show the collective migration of the lens epithelial cells across the ECZ led by mesenchymal leader cells (arrow)."
sparser
"Formation of the ECZ in response to injury is best observed by time-lapse microscopy (Supplemental Video 1, representative still images shown in Figure 1, BiBiii)."
CACNA1B binds APBB1, BI, and BII. 1 / 1
| 1
sparser
"Electrophoretic mobility-shift assays performed with rat brain nuclear extracts showed that three major DNA-protein complexes, named BI, BII and BIII, are formed by the FE65 minimal promoter."
Syntaxin affects CACNA1B
| 5
sparser
"Our findings are in agreement with earlier studies which reported that interruption of the CaV2.2syntaxin interaction with synprint peptides inhibits fast, synchronous transmitter release. xref "
sparser
"If syntaxin interaction with Cav2.2 primarily serves to localize the channel to the exocytotic machinery [ xref ], rather than modulating channel activity, this may reconcile the findings that PKC does not affect calcium channel currents but that channel modification by PKC is an important regulatory mechanism."
sparser
"PKC increases the interaction of syntaxin with Cav2.2 which modulates the calcium channel whereas phosphorylated synaptotagmin increases the affinity of insulin granules to SNARE complex near the membrane surface, ultimately leading to insulin secretion from cell (Trexler and Taraska, 2017)."
sparser
"If syntaxin interaction with Cav2.2 primarily serves to localize the channel to the exocytotic machinery [101] , rather than modulating channel activity, this may reconcile the findings that PKC does not affect calcium channel currents but that channel modification by PKC is an important regulatory mechanism."
sparser
"The notion of PPIs altering CaV2.2 channel function was proposed almost two decades ago by William Catterall and colleagues who discovered that interruption of the CaV2.2-syntaxin interaction with SYNaptic Protein INTeraction (synprint) peptides inhibits fast, synchronous transmitter release [ xref , xref , xref , xref ]."
PDLIM5 affects CACNA1B
1 2 | 1
1 1 | 1
bel
"Within the physiological Ca2+ concentration range (0-300 microM), binding of ENH to the channel C-terminus was significantly increased by Ca2+, whereas increased Ca2+ levels led to dissociation of PKCepsilon from ENH."
hprd
No evidence text available
sparser
"However, the mechanism by which ENH and Cav2.2 interact remains controversial xref ."
1 |
hprd
No evidence text available
CACNA1B affects DPYSL2, NF1, and STX1A
| 4
| 4
sparser
"In this platform, neurofibromin interacts with CRMP2 to prevent recruitment of syntaxin 1A and CaV2.2, thus leading to block of CGRP and a reduction in pain behaviors."
sparser
"Our work also identifies a novel tool–the CRMP2-derived aptamer CNRP, which is capable of uncoupling CRMP2’s interactions with neurofibromin, syntaxin 1A, and Cav2.2."
sparser
"We previously found that this peptide inhibited CRMP2’s interaction with CaV2.2, neurofibromin, and syntaxin 1A. A cell-penetrant version of this peptide (t-CNRP1) inhibited CaV2.2 and NaV1.7 currents in Nf1 -edited neurons."
sparser
"These results suggest that targeting CRMP2 interactions with neurofibromin, syntaxin 1A and Cav2.2 is beneficial for nociceptive pain behaviors in a rat model of HIV-SN."
CACNA1B affects BII
| 3 1
CACNA1B binds BII. 3 / 3
| 2 1
sparser
"Seed samples of plants with higher ploidy levels showed an extensive variation in the mode of reproduction: BII and BIII hybrid formation and/or aposporous pseudogamy including parthenogenetic development of a reduced embryo sac."
sparser
"However, a new arrangement with one residue shifted and the backbone flipped (Figure xref BIII) is possible under acidic conditions.( xref ) It can be seen that both arrangements in Figure xref BII and BIII present favorable hydrophobic interactions; however, the antiparallel one residue-shifted arrangement (Figure xref BIII) may have better aromatic interactions derived from two nearby Phe residues."
reach
"The BII and BIII complexes exhibited binding crossreactivity with other kappa B related motifs and recognized both the perfect and imperfect palindromic sequences, whereas the BI complex was specific for the perfect palindromic sequence which is unique to the class I promoters."
CACNA1B binds APBB1, BI, and BII. 1 / 1
| 1
sparser
"Electrophoretic mobility-shift assays performed with rat brain nuclear extracts showed that three major DNA-protein complexes, named BI, BII and BIII, are formed by the FE65 minimal promoter."
Agmatine affects CACNA1B
| 3
| 3
sparser
"Therefore, in the present study, we investigated the electrophysiological mechanism for the agmatine-induced inhibition of Cav2.2 current (I Cav2.2 ) in rat celiac ganglion (CG) neurons."
sparser
"Consistent with previous reports, agmatine inhibited I Cav2.2 in a VI manner."
sparser
"However, the detailed cellular signaling mechanism underlying the agmatine-induced Cav2.2 inhibition remains unclear."
RGS12 affects CACNA1B
1 | 2
1 | 2
sparser
"Using a combination of biochemical and electrophysiological approaches, we have determined that the SNARE binding or "synprint" region of the Cav2.2 binds to RGS12."
sparser
"Furthermore, we found that calcium sensing receptor (CaR) is expressed in preosteoclasts and osteoclasts and that RGS12 interacts with N type Ca 2+ channels and CaR during osteoclast differentiation ( xref )."
hprd
No evidence text available
PRKCE affects CACNA1B
2 1 |
PRKCE phosphorylates CACNA1B.
1 |
Kinase-active PRKCE leads to the phosphorylation of CACNA1B on tyrosine. 1 / 1
1 |
bel
"Formation of this complex selectively recruits PKCepsilon to its specific substrate, N-type Ca2+ channels, and is critical for rapid and efficient potentiation of the Ca2+ channel activity by PKC in neurons."
PRKCE binds CACNA1B.
1 |
1 |
hprd
No evidence text available
PRKCE activates CACNA1B.
1 |
Kinase-active PRKCE activates CACNA1B. 1 / 1
1 |
bel
"Formation of this complex selectively recruits PKCepsilon to its specific substrate, N-type Ca2+ channels, and is critical for rapid and efficient potentiation of the Ca2+ channel activity by PKC in neurons."
MAPK1 affects CACNA1B
2 | 1
MAPK1 phosphorylates CACNA1B.
2 |
MAPK1 phosphorylates CACNA1B on S411. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
MAPK1 phosphorylates CACNA1B on S447. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
MAPK1 increases the amount of CACNA1B.
| 1
Modified MAPK1 increases the amount of CACNA1B. 1 / 1
| 1
reach
"Suppression of MAPK1 expression inhibited the gene and protein expression of Cacna1b, Cacna1e, Grm1, and Grm1 (P < 0.001, Fig."
| 3
sparser
"Co-immunoprecipitations from brain tissue is consistent with the formation of a protein complex between RB-3α and RB-3β and both Cav2.2 and the related Cav2.1 calcium channel."
sparser
"A recently discovered interaction between the N-type calcium channel, CaV2.2 and collapsin response mediator protein 2 (CRMP-2) positively regulated channel functions by increasing CaV2.2’s cell surface trafficking [ xref - xref ]."
sparser
"For instance, association of several voltage-dependent calcium channel genes such as CACNA1C and CACNA1B was reported in large-scale GWAS for BD. xref , xref A pathway analysis of GWAS data suggests enrichment of calcium channel-related pathways among the genes empirically associated with BD. xref Studies of peripheral blood cells have consistently demonstrated altered intracellular calcium signaling in BD. xref , xref Lithium, the first-line therapeutic drug for BD, modulates inositol-mediated pathways xref and thereby regulate calcium ion release from the endoplasmic reticulum. xref When we performed a GO enrichment analysis using DAVID xref , xref by integrating the data of de novo protein-altering mutations in our study, common single-nucleotide polymorphisms associated with BD in a large-scale GWAS xref and rare CNVs implicated in BD xref (total no. of unique input genes=229, see xref for details), ‘calcium signaling pathway (hsa04020)' was the only term significantly enriched after performing correction for multiple testing ( P corrected =6.4 × 10 −3 , Bonferroni correction; note that significant enrichment of ‘calcium signaling pathway (hsa04020)' after correction was not observed when we submitted candidate genes from each study)."
CDK5 affects CACNA1B
| 1 2
CDK5 phosphorylates CACNA1B. 3 / 3
| 1 2
rlimsp
"The increased association between Cdk5-phosphorylated CRMP2 and CaV2.2 was reduced by (S)-LCM in vitro and in vivo."
sparser
"The increased association between Cdk5-phosphorylated CRMP2 and CaV2.2 was reduced by (S)-LCM in vitro and in vivo."
sparser
"With the exception of lacosamide, which reduced the association between Cdk5-phosphorylated CRMP2 and CaV2.2 in vitro and in vivo ( xref ), the binding of small molecules to CRMP2 has rarely been reported."
CACNA1B affects RGS12
1 | 2
1 | 2
sparser
"Using a combination of biochemical and electrophysiological approaches, we have determined that the SNARE binding or "synprint" region of the Cav2.2 binds to RGS12."
sparser
"Furthermore, we found that calcium sensing receptor (CaR) is expressed in preosteoclasts and osteoclasts and that RGS12 interacts with N type Ca 2+ channels and CaR during osteoclast differentiation ( xref )."
hprd
No evidence text available
CACNA1B affects DPYSL2, and NF1
| 3
| 3
sparser
"Neurons treated with tat-CRMP2/neurofibromin regulating peptide 1 (t-CNRP1) exhibited a decreased Cav2.2 membrane localization, and uncoupling of neurofibrominCRMP2 and CRMP2Cav2.2 interactions."
sparser
"Collectively, these results demonstrate that t-CNRP1 decreases Cav2.2-dependent Ca 2+ influx, currents, and surface localization through disruption of CRMP2’s binding to Cav2.2 and neurofibromin."
sparser
"Our goal was to identify the component(s) of the CRMP2neurofibromin interaction that regulate Cav2.2 activity."
CACNA1B affects DEFB103A, DPYSL2, and TAT
| 3
| 3
sparser
"We previously reported that uncoupling the CaV2.2CRMP2 interaction with TAT- [ xref ] or R9-CBD3 [ xref ] resulted in a reduction of depolarization-induced Ca 2+ -influx in sensory neurons."
sparser
"To determine if perturbing the CRMP-2CaV2.2 interaction with the TAT-CBD3 peptide can modulate transmitter release, resting and potassium-stimulated release of immunoreactive CGRP (iCGRP) was measured from supernatants of DRG neurons in culture that were treated with 10 μM TAT-CBD3 or TAT scramble."
sparser
"We previously reported that uncoupling the CaV2.2CRMP2 interaction with tat-CBD3 resulted in reduction of depolarization-induced Ca 2+ -influx in sensory neurons. xref Here, we asked whether the myr-tat-CBD3 peptide could work similarly."
| 3
sparser
"Co-immunoprecipitations from brain tissue is consistent with the formation of a protein complex between RB-3α and RB-3β and both Cav2.2 and the related Cav2.1 calcium channel."
sparser
"A recently discovered interaction between the N-type calcium channel, CaV2.2 and collapsin response mediator protein 2 (CRMP-2) positively regulated channel functions by increasing CaV2.2’s cell surface trafficking [ xref - xref ]."
sparser
"For instance, association of several voltage-dependent calcium channel genes such as CACNA1C and CACNA1B was reported in large-scale GWAS for BD. xref , xref A pathway analysis of GWAS data suggests enrichment of calcium channel-related pathways among the genes empirically associated with BD. xref Studies of peripheral blood cells have consistently demonstrated altered intracellular calcium signaling in BD. xref , xref Lithium, the first-line therapeutic drug for BD, modulates inositol-mediated pathways xref and thereby regulate calcium ion release from the endoplasmic reticulum. xref When we performed a GO enrichment analysis using DAVID xref , xref by integrating the data of de novo protein-altering mutations in our study, common single-nucleotide polymorphisms associated with BD in a large-scale GWAS xref and rare CNVs implicated in BD xref (total no. of unique input genes=229, see xref for details), ‘calcium signaling pathway (hsa04020)' was the only term significantly enriched after performing correction for multiple testing ( P corrected =6.4 × 10 −3 , Bonferroni correction; note that significant enrichment of ‘calcium signaling pathway (hsa04020)' after correction was not observed when we submitted candidate genes from each study)."
2 |
Transcriptionally active hsa-miR-8485 decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-6858-5p decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-6844 decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-499b-3p decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-499a-3p decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-4784 decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-4689 decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-3915 decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-377-3p decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-3150b-3p decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-1304-5p decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
2 |
Transcriptionally active hsa-miR-1224-5p decreases the amount of CACNA1B. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
biopax:mirtarbase
No evidence text available
UBE2L3 affects CACNA1B
2 |
biogrid
No evidence text available
biogrid
No evidence text available
SCEI affects CACNA1B
| 2
| 1
sparser
"We optimized recombinant expression in human embryonic kidney (HEK) 293 cells of alpha 1B alpha 2b beta 1 subunit complexes by controlling the expression levels of subunit mRNAs and monitored cell surface expression by binding of omega-CgTx GVIA to the alpha 1B subunit."
CACNA1A binds CACNA1B, SCEI, and CTX. 1 / 1
| 1
sparser
"These results suggested that the characteristics of the specific binding of 125I-omega-CTX GVIA and 125I-omega-CTX MVIIC to Cav2.1 and Cav2.2 channels in the NBM were very similar to those to crude membranes from chick brain, although the IC50 values for CaM and free Ca2+ of CaM were about 33- and 5000-fold higher, respectively, than those for the specific binding of 125I-omega-CTX GVIA and 125I-omega-CTX MVIIC to crude membranes."
OTG affects CACNA1B
| 2
CACNA1B binds OTG. 2 / 2
| 2
reach
"Contoured sections are bounded with a box and superimposed on a Ca backbone drawing of either (a) the refined BIII and OTG complex (Anderson et al., 1978h) positioned in the HKA G unit cell so as to superimpose the large lobe of this model on that of the refined HKA-G model, or (b) the refined HKA-G model."
reach
"The BIII and OTG complex is essentially isomorphous to the native Bill structure (Fletterick et al., 1975)."
NOG affects CACNA1B
2 |
NOG increases the amount of CACNA1B.
1 |
Transcriptionally active NOG increases the amount of CACNA1B. 1 / 1
1 |
biopax:ctd
No evidence text available
NOG decreases the amount of CACNA1B.
1 |
Transcriptionally active NOG decreases the amount of CACNA1B. 1 / 1
1 |
biopax:ctd
No evidence text available
MAPK3 affects CACNA1B
2 |
MAPK3 phosphorylates CACNA1B on S447. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
MAPK3 phosphorylates CACNA1B on S411. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
MAP1LC3B affects CACNA1B
2 |
biogrid
No evidence text available
biogrid
No evidence text available
MAP1B affects CACNA1B
1 | 1
1 |
biogrid
No evidence text available
| 1
sparser
"On the other hand, MAP1B interacts with CaV2.2 and 5-HT3A to reduce their expression in the plasma membrane and promoting their desensitization xref , xref ."
GNAO1 affects CACNA1B
1 1 |
1 1 |
biogrid
No evidence text available
hprd
No evidence text available
FYN affects CACNA1B
| 2
FYN activates CACNA1B. 2 / 2
| 2
sparser
"α-Syn selectively activates neuronal Cav2.2 channels and increases neurotransmitter release including dopamine [ xref ]."
sparser
"α-Syn selectively activates neuronal Cav2.2 channels and increases neurotransmitter release including dopamine [ xref ]."
FMR1 affects CACNA1B
| 2
| 2
sparser
"Interestingly, we find here that the effect of FMRP on Ca V 2.2 expression is antagonized by a proteasome inhibitor, and we found that the interaction between FMRP and Cav2.2 does not co-immunoprecipitate Ca V β subunits, suggesting that it occurs with channels that have lost, or subsequently lose, the protective interaction with Ca V β subunits xref ."
sparser
"For instance, knockdown experiments have suggested that FMRP may interact with N-type calcium channel Cav2.2 [ xref ] and repress NMDAR subunit translation [ xref ]."
CAMK2A affects CACNA1B
2 |
CAMK2A phosphorylates CACNA1B.
1 |
CAMK2A phosphorylates CACNA1B on S2120. 1 / 1
1 |
signor
"Here, we report a direct modulation of ca(v)2.2 channel inactivation properties by 14-3-3, a family of signaling proteins involved in a wide range of biological processes.Wild-type gst fusion proteins containing the putative 14-3-3-binding motif (aa 2076__?2140) werein vitro phosphorylated at s2126 by either camkii or pka, as detected by thesequence- and phosphorylation-specific antibody, anti-ps2126 (middle panel). Phosphorylation of s2126 significantly increases its binding to recombinant 14-3-3?"
CAMK2A inhibits CACNA1B.
1 |
1 |
signor
"Here, we report a direct modulation of ca(v)2.2 channel inactivation properties by 14-3-3, a family of signaling proteins involved in a wide range of biological processes.Wild-type gst fusion proteins containing the putative 14-3-3-binding motif (aa 2076__?2140) werein vitro phosphorylated at s2126 by either camkii or pka, as detected by thesequence- and phosphorylation-specific antibody, anti-ps2126 (middle panel). Phosphorylation of s2126 significantly increases its binding to recombinant 14-3-3?"
CACNA1B affects respiratory associated eosinophilia
| 2
CACNA1B activates respiratory associated eosinophilia. 2 / 2
| 2
eidos
"The main causes of respiratory conditions associated with eosinophilia are acute schistosomiasis , Loffler 's syndrome and paragonimiasis ( B-III ) ."
eidos
"The main causes of respiratory conditions associated with eosinophilia are acute schistosomiasis , Loffler 's syndrome and paragonimiasis ( B-III ) ."
| DOI
CACNA1B affects microtubule turnover
| 2
CACNA1B activates microtubule turnover. 2 / 2
| 2
eidos
"Thus , the increase in betaIII levels during neurogenesis results in higher microtubule turnover ."
eidos
"Thus , the increase in betaIII levels during neurogenesis results in higher microtubule turnover ."
| 2
| 1
reach
"Both voltage activated and deltamethrin activated human Nav1.8 were inhibited by the sodium channel blockers BIII 890 CL, NW-1029, and mexiletine."
reach
"The model further proposes that the lower-affinity enantiomer BIII 281 CL binds in modes with one and two but not all three interaction points docked."
CACNA1B affects UBE2L3
2 |
biogrid
No evidence text available
biogrid
No evidence text available
CACNA1B affects SCEI
| 2
| 1
sparser
"We optimized recombinant expression in human embryonic kidney (HEK) 293 cells of alpha 1B alpha 2b beta 1 subunit complexes by controlling the expression levels of subunit mRNAs and monitored cell surface expression by binding of omega-CgTx GVIA to the alpha 1B subunit."
CACNA1A binds CACNA1B, SCEI, and CTX. 1 / 1
| 1
sparser
"These results suggested that the characteristics of the specific binding of 125I-omega-CTX GVIA and 125I-omega-CTX MVIIC to Cav2.1 and Cav2.2 channels in the NBM were very similar to those to crude membranes from chick brain, although the IC50 values for CaM and free Ca2+ of CaM were about 33- and 5000-fold higher, respectively, than those for the specific binding of 125I-omega-CTX GVIA and 125I-omega-CTX MVIIC to crude membranes."
CACNA1B affects OTG
| 2
CACNA1B binds OTG. 2 / 2
| 2
reach
"Contoured sections are bounded with a box and superimposed on a Ca backbone drawing of either (a) the refined BIII and OTG complex (Anderson et al., 1978h) positioned in the HKA G unit cell so as to superimpose the large lobe of this model on that of the refined HKA-G model, or (b) the refined HKA-G model."
reach
"The BIII and OTG complex is essentially isomorphous to the native Bill structure (Fletterick et al., 1975)."
CACNA1B affects MAP1LC3B
2 |
biogrid
No evidence text available
biogrid
No evidence text available
CACNA1B affects MAP1B
1 | 1
1 |
biogrid
No evidence text available
| 1
sparser
"On the other hand, MAP1B interacts with CaV2.2 and 5-HT3A to reduce their expression in the plasma membrane and promoting their desensitization xref , xref ."
CACNA1B affects GNAO1
1 1 |
1 1 |
biogrid
No evidence text available
hprd
No evidence text available
CACNA1B affects FMR1
| 2
| 2
sparser
"Interestingly, we find here that the effect of FMRP on Ca V 2.2 expression is antagonized by a proteasome inhibitor, and we found that the interaction between FMRP and Cav2.2 does not co-immunoprecipitate Ca V β subunits, suggesting that it occurs with channels that have lost, or subsequently lose, the protective interaction with Ca V β subunits xref ."
sparser
"For instance, knockdown experiments have suggested that FMRP may interact with N-type calcium channel Cav2.2 [ xref ] and repress NMDAR subunit translation [ xref ]."
CACNA1B affects DPYSL2, and STX1A
| 2
| 2
sparser
"We propose that CNRP1 uncouples CRMP2’s interactions with Cav2.2 and syntaxin 1A, resulting in Cav2.2 relocalization away from the plasma membrane; decreased synaptic vesicle docking to the Ca 2+ channel; and consequently, decreased CGRP release."
sparser
"However, loss of neurofibromin, as observed in NF1 patients, results in disinhibition of the tripartite CRMP2-Cav2.2-syntaxin 1A interaction, therefore permitting increased N-type Ca 2+ currents and CGRP release."
CACNA1B affects APBA1
2 |
2 |
hprd
No evidence text available
hprd
No evidence text available
ANK2 affects CACNA1A, and CACNA1B
| 2
| 2
sparser
"Here, we demonstrate that ankyrin-B associates with Cav2.1 and Cav2.2 in cortex, cerebellum, and brain stem."
sparser
"Collectively, our findings identify an interaction between ankyrin-B and both Cav2.1 and Cav2.2 at the amino acid level that is necessary for proper Cav2.1 and Cav2.2 targeting in vivo."
Α2δ-1 affects CACNA1B
| 1
CACNA1B binds α2δ-1. 1 / 1
| 1
sparser
"Also, intrathecal administration of α2δ-1Tat peptide had no effect on the interaction between α2δ-1 and Cav2.2 proteins in the spinal cord tissue ( xref )."
| 1
reach
"The N-acetylgalactosamine in Component B-I was obtained as preformed Morgan-Elson chromogen, and Components B-I and B-III were not obtained when the glycopeptides were treated with alkaline NaBH4 under conditions which prevent peeling."
| 1
| 1
reach
"With regards to voltage gated calcium (Ca 2+) channels (XREF_FIG), Na + deficiency significantly upregulated Cacna1i (Ca v 3.3; T-type), Cacna1e (Ca v 2.3; R-type), Cacna1c (Ca v 1.2; L-type) and Cacna1b (Ca v 2.2; N-type)."
| 1
reach
"In these WT females estrogen fostered ductal dilation, while estrogen and progesterone together stimulated extensive lobuloalveologenesis (XREF_FIG Biii, iv)."
| 1
reach
"The model further proposes that the lower-affinity enantiomer BIII 281 CL binds in modes with one and two but not all three interaction points docked."
1 |
Transcriptionally active hsa-miR-8072 decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-642b-3p decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-642a-3p decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-5739 decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-542-3p decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-4504 decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-3960 decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-335-5p decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-3186-3p decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-25-5p decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-1914-5p decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
1 |
Transcriptionally active hsa-miR-15b-3p decreases the amount of CACNA1B. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
Estrogen affects CACNA1B
| 1
| 1
reach
"In these WT females estrogen fostered ductal dilation, while estrogen and progesterone together stimulated extensive lobuloalveologenesis (XREF_FIG Biii, iv)."
| 1
sparser
"Thus, we conclude that betulinic acid preferentially inhibits Cav3.2 (T-type) and Cav2.2 (N-type) Ca 2+ channel subunits."
Baclofen affects CACNA1B
| 1
| 1
sparser
"Furthermore, overexpression of GINIP in tsA-201 cells strongly inhibited G αi -evoked decrease in cAMP levels and significantly increased the time constant of recovery from DAMGO- and baclofen-induced inhibition of Cav2.2 channels."
UBA2 affects CACNA1B
| 1
UBA2 inhibits CACNA1B. 1 / 1
| 1
sparser
"Moreover, when the C terminus of β-adrenergic receptor kinase (which binds Gβγ) was coexpressed with N-type channels, inhibition of CaV2.2 current after M1 receptor activation was markedly reduced and delayed, whereas the delay between PIP2 hydrolysis and inhibition of CaV2.2 current was decreased."
Tubulin affects CACNA1B
| 1
sparser
"In the non-invasive front group, staining intensity of bIII-tubulin was significantly associated with positive staining rates and lymphatic metastasis (p<0.001 and p=0.048)."
TNFAIP8 affects CACNA1B
| 1
TNFAIP8 increases the amount of CACNA1B. 1 / 1
| 1
isi
"In the validation set, by univariate Cox regression analysis, high expression of ARHGAP19 , MESD , WDCP , DIP2A , CACNA1B , TNFAIP8 , POLR3H , ENO3 , SERPINB8 , SZRD1 , KIF23 and GGA3 associated to poor, and high SFTPC , ZSCAN12 , LPXN and METTL21A to favorable outcome."
TNF affects CACNA1B
| 1
| 1
sparser
"Inhibition of N-type VGCCs following TNFalpha incubation was associated with a decrease in CaV2.2 mRNA and reduced membrane localization of CaV2.2 immunoreactivity."
T-477 affects CACNA1B
| 1
T-477 inhibits CACNA1B. 1 / 1
| 1
reach
"Extracellular application of T-477 suppressed the BII and BIII currents, without changing the shape of the I - V curve."
SRC affects CACNA1B
| 1
SRC inhibits CACNA1B. 1 / 1
| 1
sparser
"MOR inhibition of substance P release in our conditions is likely mediated by Src family kinase inactivation of CaV2.2, because high frequency stimulation of the dorsal root depolarizes primary afferent terminals and therefore removes the voltage-dependent Gβγ inactivation."
RXRB affects CACNA1B
1 |
1 |
biogrid
No evidence text available
RPL9 affects CACNA1B
1 |
1 |
biogrid
No evidence text available
RIMS1 affects CACNA1B
1 |
1 |
hprd
No evidence text available
PPM1A affects CACNA1B
1 |
1 |
hprd
No evidence text available
POLR3H affects CACNA1B
| 1
POLR3H increases the amount of CACNA1B. 1 / 1
| 1
isi
"In the validation set, by univariate Cox regression analysis, high expression of ARHGAP19 , MESD , WDCP , DIP2A , CACNA1B , TNFAIP8 , POLR3H , ENO3 , SERPINB8 , SZRD1 , KIF23 and GGA3 associated to poor, and high SFTPC , ZSCAN12 , LPXN and METTL21A to favorable outcome."
PKC affects CACNA1B
| 1
PKC inhibits CACNA1B. 1 / 1
| 1
sparser
"O55017) as S424 mediates PKC-dependent Cav2.2 inhibition ( xref ; xref )."
NMDAR affects CACNA1B
| 1
| 1
sparser
"Whole-cell voltage-clamp and single-channel recording were used to study the interaction of BIII 277 CL and its enantiomer BIII 281 CL with native NMDA receptors in cultured hippocampal neurons."
MTNR1A affects CACNA1B
1 |
biogrid
No evidence text available
LCM affects CACNA1B
| 1
LCM inhibits CACNA1B. 1 / 1
| 1
sparser
"We previously reported that ( S )-LCM specifically inhibits CaV2.2 in DRGs. xref It is possible that other (ie, P/Q- or L-type xref ) voltage-gated calcium channels may contribute to the Ca 2+ influx in TGs."
| 1
sparser
"Furthermore, T4 inhibited CaV2.2 channels more potently when channel inactivation was driven through a tonic sub-threshold depolarization rather than through a use-dependent protocol, despite similar levels of inactivation."
KIAA0513 affects CACNA1B
| 1
sparser
"IBSP , MEPE , RELN and THSD7A are associated with migration, invasion, infiltration and angiogenesis [ xref – xref ]; CACNA1B and KIAA0513 are associated with cell proliferation and apoptosis."
KCS16 affects CACNA1B
| 1
| 1
sparser
"On the other hand, the conserved histidine (H) residue in H type connexins does not form a comparably stable complex with the K-N type EL2 motifs."
HTT affects CACNA1B
| 1
| 1
sparser
"The association of the N-terminal domain of huntingtin (both mutant and normal) with the pore-forming CaV2.2 subunit of N-type VGCC leads to a displacement of the syntaxin 1A that negatively regulates the channel and, as a result, to an increase in the activity of N-type VGCC [ xref ]."
HHEX affects CACNA1B
| 1
HHEX activates CACNA1B. 1 / 1
| 1
reach
"In T. media cell cultures Hex also had a negative effect on TX production but enhanced the accumulation of BIII and CEPH, as discussed above."
G_protein affects CACNA1B
| 1
| 1
sparser
"Finally, since N-, P/Q- and R-type calcium currents can be inhibited by activation of GPCRs that are linked to G i/o (for a review, see [ xref ]), we tested if ( S )-LCM affects G-protein inhibition of CaV2.2, which can be relieved by depolarization. ( S )-LCM did not affect the ratio of currents between the pulses ( xref ), ruling out involvement of G-proteins in its regulation of CaV2.2."
GNB2 affects CACNA1B
1 |
1 |
biogrid
No evidence text available
GNB1 affects CACNA1B
1 |
1 |
hprd
No evidence text available
ENO3 affects CACNA1B
| 1
ENO3 increases the amount of CACNA1B. 1 / 1
| 1
isi
"In the validation set, by univariate Cox regression analysis, high expression of ARHGAP19 , MESD , WDCP , DIP2A , CACNA1B , TNFAIP8 , POLR3H , ENO3 , SERPINB8 , SZRD1 , KIF23 and GGA3 associated to poor, and high SFTPC , ZSCAN12 , LPXN and METTL21A to favorable outcome."
Dup99B affects CACNA1B
| 1
| 1
reach
"Consistent with this is the finding that Dup99B, unlike Acp70A, can not stimulate the release of JH BIII in in vitro assays [38]."
DIP2A affects CACNA1B
| 1
DIP2A increases the amount of CACNA1B. 1 / 1
| 1
isi
"In the validation set, by univariate Cox regression analysis, high expression of ARHGAP19 , MESD , WDCP , DIP2A , CACNA1B , TNFAIP8 , POLR3H , ENO3 , SERPINB8 , SZRD1 , KIF23 and GGA3 associated to poor, and high SFTPC , ZSCAN12 , LPXN and METTL21A to favorable outcome."
Calcium affects CACNA1B
1 |
Calcium increases the amount of CACNA1B bound to PDLIM5. 1 / 1
1 |
bel
"Within the physiological Ca2+ concentration range (0-300 microM), binding of ENH to the channel C-terminus was significantly increased by Ca2+, whereas increased Ca2+ levels led to dissociation of PKCepsilon from ENH."
CI affects CACNA1B
| 1
| 1
sparser
"The aim of the present study was to assess the association of the human CACNA1B gene with the occurrence of CI via a haplotype-based case-control study that used single nucleotide polymorphisms (SNPs) from the Japanese population."
CD1A affects CACNA1B
| 1
CD1A inhibits CACNA1B. 1 / 1
| 1
sparser
"In patch-clamp electrophysiological assays Cd1a inhibited rat Cav2.2 with similar potency (IC50 3 μM) without influencing the voltage dependence of Cav2.2 activation gating, suggesting that Cd1a doesn't act on Cav2.2 as a classical gating modifier toxin."
CACNA1B affects α2δ-1
| 1
CACNA1B binds α2δ-1. 1 / 1
| 1
sparser
"Also, intrathecal administration of α2δ-1Tat peptide had no effect on the interaction between α2δ-1 and Cav2.2 proteins in the spinal cord tissue ( xref )."
| 1
| 1
reach
"Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL."
| 1
CACNA1B increases the amount of pyraclofos. 1 / 1
| 1
reach
"We also provide evidence of altered mRNA expression of (1) voltage gated calcium channels P/Q-type Cacna1a (Cav 2.1), N-type Cacna1b (Cav 2.2), T-type Cav 3.1 Cacna1g, Cav 3.2 Cacna1h, Cav 3.3 Cacna1i and the auxiliary subunit Cacna2d1 (alpha2delta1); (2) hyperpolarization activated cyclic nucleotide gated channels Hcn1 and Hcn2; and (3) glutamate receptors subunits AMPA-type Gria1, NMDA-type Grin1 and metabotropic Grm1 in the mouse mPFC after repeated METH treatment."
| 1
reach
"Nuclear localization of RAG1 is also mediated by the BI, BII, and BIII basic motifs at the N terminus of the protein and to a lesser extent by the BIV basic motif."
CACNA1B affects ferritin
| 1
CACNA1B increases the amount of ferritin. 1 / 1
| 1
reach
"Case BIII.1 had mild microcytic anaemia, reticulocytosis, and increased ferritin levels; 17% of stomatocytes were detected at blood smear examination (XREF_TABLE and XREF_FIG); the molecular testing for HBB gene revealed the presence of the splicing mutation c.93-21G> A at heterozygote level, confirming the beta-thalassemia trait."
CACNA1B affects alpha1 subunit
| 1
CACNA1B activates alpha1 subunit. 1 / 1
| 1
reach
"The CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E and CACNA1G genes produce various isoform of alpha1 subunit including A, B, C, D, E and G, respectively."
CACNA1B affects actin-FA
| 1
| 1
reach
"This strengthened the FA-ECM linkage by recruiting more adaptors and integrins (XREF_FIG Bii), and stimulating the FA localized PTK activities that phosphorylated the FA adaptor (e.g., pY-paxillin) (XREF_FIG Biii), which in turn potentiated actin-FA engagement."
CACNA1B affects Tubulin
| 1
sparser
"In the non-invasive front group, staining intensity of bIII-tubulin was significantly associated with positive staining rates and lymphatic metastasis (p<0.001 and p=0.048)."
CACNA1B affects TNFAIP8
| 1
CACNA1B increases the amount of TNFAIP8. 1 / 1
| 1
isi
"In the validation set, by univariate Cox regression analysis, high expression of ARHGAP19 , MESD , WDCP , DIP2A , CACNA1B , TNFAIP8 , POLR3H , ENO3 , SERPINB8 , SZRD1 , KIF23 and GGA3 associated to poor, and high SFTPC , ZSCAN12 , LPXN and METTL21A to favorable outcome."
CACNA1B affects TNF
| 1
| 1
sparser
"Inhibition of N-type VGCCs following TNFalpha incubation was associated with a decrease in CaV2.2 mRNA and reduced membrane localization of CaV2.2 immunoreactivity."
CACNA1B affects SP1
| 1
CACNA1B inhibits SP1. 1 / 1
| 1
reach
"Nuclear protein complexes BII, BIII, CII, and CIII, were significantly decreased by the addition of cold competitor containing a core Sp1 element."
CACNA1B affects RXRB
1 |
1 |
biogrid
No evidence text available
CACNA1B affects RPL9
1 |
1 |
biogrid
No evidence text available
CACNA1B affects RIMS1
1 |
1 |
hprd
No evidence text available
CACNA1B affects PRKN, and UBE3A
| 1
| 1
sparser
"Immunoprecipitation assays confirmed the interaction between UBE3A and Parkin with CaV2.2 channels heterologously expressed in HEK-293 cells and in neural tissues."
CACNA1B affects PPM1A
1 |
1 |
hprd
No evidence text available
CACNA1B affects POLR3H
| 1
CACNA1B increases the amount of POLR3H. 1 / 1
| 1
isi
"In the validation set, by univariate Cox regression analysis, high expression of ARHGAP19 , MESD , WDCP , DIP2A , CACNA1B , TNFAIP8 , POLR3H , ENO3 , SERPINB8 , SZRD1 , KIF23 and GGA3 associated to poor, and high SFTPC , ZSCAN12 , LPXN and METTL21A to favorable outcome."
CACNA1B affects PDLIM5, and PRKCE
1 |
1 |
hprd
No evidence text available
CACNA1B affects PCP
| 1
CACNA1B activates PCP. 1 / 1
| 1
reach
"Patients who have PCP during TMP-SMX prophylaxis also can be treated with TMP-SMX (BIII) [XREF_BIBR]."
CACNA1B affects P2
| 1
CACNA1B activates P2. 1 / 1
| 1
reach
"The CNBr peptide BIII produces only the single peptide P2."
CACNA1B affects NMDAR
| 1
| 1
sparser
"Whole-cell voltage-clamp and single-channel recording were used to study the interaction of BIII 277 CL and its enantiomer BIII 281 CL with native NMDA receptors in cultured hippocampal neurons."
CACNA1B affects NMDA receptor
| 1
CACNA1B activates NMDA receptor. 1 / 1
| 1
reach
"BIII 277 CL and BIII 281 CL produced a slow use dependent block of whole-cell NMDA receptor currents."
CACNA1B affects Met-Asp
| 1
| 1
reach
"In DYT23, a p.Arg1389His variant in CACNA1B encoding the voltage gated calcium channel Cav2.2 was reported to cause MD plus in a large Dutch family."
CACNA1B affects MTNR1A
1 |
biogrid
No evidence text available
CACNA1B affects KIAA0513
| 1
sparser
"IBSP , MEPE , RELN and THSD7A are associated with migration, invasion, infiltration and angiogenesis [ xref – xref ]; CACNA1B and KIAA0513 are associated with cell proliferation and apoptosis."
CACNA1B affects KCS16
| 1
| 1
sparser
"On the other hand, the conserved histidine (H) residue in H type connexins does not form a comparably stable complex with the K-N type EL2 motifs."
CACNA1B affects HTT
| 1
| 1
sparser
"The association of the N-terminal domain of huntingtin (both mutant and normal) with the pore-forming CaV2.2 subunit of N-type VGCC leads to a displacement of the syntaxin 1A that negatively regulates the channel and, as a result, to an increase in the activity of N-type VGCC [ xref ]."
CACNA1B affects HTR3A, and MAP1B
| 1
| 1
sparser
"On the other hand, MAP1B interacts with CaV2.2 and 5-HT3A to reduce their expression in the plasma membrane and promoting their desensitization xref , xref ."
CACNA1B affects Grin3a
| 1
| 1
reach
"N-methyl-D-aspartate receptor channel block by the enantiomeric 6,7-benzomorphans BIII 277 CL and BIII 281 CL."
CACNA1B affects GNB2
1 |
1 |
biogrid
No evidence text available
CACNA1B affects GNB1
1 |
1 |
hprd
No evidence text available
CACNA1B affects EVA1C
| 1
CACNA1B activates EVA1C. 1 / 1
| 1
reach
"Two epitopes (comprising amino acids 352-368 and 386-397) of domain BIII of the envelope glycoprotein were chosen to produce recombinant B19 VLPs for immunization of BALB/c mice."
CACNA1B affects ERVK-9
| 1
| 1
sparser
"While it may be that BIII inhibits proteases or amylases not assayed, the results presented here suggest that caution should be exercised, particularly for this family, in drawing functional conclusions solely from sequence information."
CACNA1B affects ENO3
| 1
CACNA1B increases the amount of ENO3. 1 / 1
| 1
isi
"In the validation set, by univariate Cox regression analysis, high expression of ARHGAP19 , MESD , WDCP , DIP2A , CACNA1B , TNFAIP8 , POLR3H , ENO3 , SERPINB8 , SZRD1 , KIF23 and GGA3 associated to poor, and high SFTPC , ZSCAN12 , LPXN and METTL21A to favorable outcome."
CACNA1B affects DPYSL2, and STR1
| 1
| 1
sparser
"We previously reported that uncoupling the CaV2.2CRMP2 interaction with ST1-104 resulted in reduction of depolarization-induced Ca 2+ -influx in sensory neurons ( xref )."
CACNA1B affects DPYSL2, and DRG
| 1
CACNA1B binds DPYSL2 and DRG. 1 / 1
| 1
sparser
"Direct protein interactions between CRMP2 and Cav2.2 in DRG sensory neurons were evident with PLA ( xref )."
CACNA1B affects DIP2A
| 1
CACNA1B increases the amount of DIP2A. 1 / 1
| 1
isi
"In the validation set, by univariate Cox regression analysis, high expression of ARHGAP19 , MESD , WDCP , DIP2A , CACNA1B , TNFAIP8 , POLR3H , ENO3 , SERPINB8 , SZRD1 , KIF23 and GGA3 associated to poor, and high SFTPC , ZSCAN12 , LPXN and METTL21A to favorable outcome."
CACNA1B affects DEFB103A, DPYSL2, STR1, and TAT
| 1
sparser
"We have demonstrated that interfering with the CaV2.2CRMP2 interaction with TAT-conjugated CBD3-scaffold peptides ST1-104, ST1-106, and ST1-107 mitigates inflammatory and neuropathic pain ( xref , xref , xref , xref )."
| 1
sparser
"A recently discovered interaction between the N-type calcium channel, CaV2.2 and collapsin response mediator protein 2 (CRMP-2) positively regulated channel functions by increasing CaV2.2’s cell surface trafficking [ xref - xref ]."
CACNA1B affects Ca 2+ influx
| 1
CACNA1B activates Ca 2+ influx. 1 / 1
| 1
reach
"Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca 2+ influx, leading to impaired synaptic neurotransmission."
CACNA1B affects CI
| 1
| 1
sparser
"The aim of the present study was to assess the association of the human CACNA1B gene with the occurrence of CI via a haplotype-based case-control study that used single nucleotide polymorphisms (SNPs) from the Japanese population."
CACNA1B affects CAV1, and NT5C2
| 1
| 1
sparser
"In vitro studies have shown physical binding of the cytosolic II-III domains of VGCC's, Cav2.2 (N 773–859 ) xref , Cav1.2 (Lc 753–893 ), and Cav2.2 (N 710–1080 ) xref , xref , xref , xref to Sx1A and other synaptic proteins."
| 1
sparser
"It is well accepted that certain hereditary forms of migraine are associated with polymorphisms of voltage-gated calcium channels Cav2.1 and Cav2.2 ( xref )."
CACNA1A affects CACNA1B, CTX, and SCEI
| 1
CACNA1A binds CACNA1B, SCEI, and CTX. 1 / 1
| 1
sparser
"These results suggested that the characteristics of the specific binding of 125I-omega-CTX GVIA and 125I-omega-CTX MVIIC to Cav2.1 and Cav2.2 channels in the NBM were very similar to those to crude membranes from chick brain, although the IC50 values for CaM and free Ca2+ of CaM were about 33- and 5000-fold higher, respectively, than those for the specific binding of 125I-omega-CTX GVIA and 125I-omega-CTX MVIIC to crude membranes."
| 1
sparser
"For instance, association of several voltage-dependent calcium channel genes such as CACNA1C and CACNA1B was reported in large-scale GWAS for BD. xref , xref A pathway analysis of GWAS data suggests enrichment of calcium channel-related pathways among the genes empirically associated with BD. xref Studies of peripheral blood cells have consistently demonstrated altered intracellular calcium signaling in BD. xref , xref Lithium, the first-line therapeutic drug for BD, modulates inositol-mediated pathways xref and thereby regulate calcium ion release from the endoplasmic reticulum. xref When we performed a GO enrichment analysis using DAVID xref , xref by integrating the data of de novo protein-altering mutations in our study, common single-nucleotide polymorphisms associated with BD in a large-scale GWAS xref and rare CNVs implicated in BD xref (total no. of unique input genes=229, see xref for details), ‘calcium signaling pathway (hsa04020)' was the only term significantly enriched after performing correction for multiple testing ( P corrected =6.4 × 10 −3 , Bonferroni correction; note that significant enrichment of ‘calcium signaling pathway (hsa04020)' after correction was not observed when we submitted candidate genes from each study)."
APBB1 affects BI, BII, and CACNA1B
| 1
CACNA1B binds APBB1, BI, and BII. 1 / 1
| 1
sparser
"Electrophoretic mobility-shift assays performed with rat brain nuclear extracts showed that three major DNA-protein complexes, named BI, BII and BIII, are formed by the FE65 minimal promoter."
| 1
reach
"Figs. 6 and 7 demonstrate that increasing TFE concentrations increase the alpha -helical contents of both BI and BIII."
CACNA1B affects calcium(2+), and calcium(2+)
|
CACNA1B catalyzes the conversion of calcium(2+) into calcium(2+). 7 / 7
7 |
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available