INDRA statements for CACNA1A

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CACNA1A affects calcium(2+)
14 | 40 21
CACNA1A activates calcium(2+).
| 15 16
CACNA1A activates calcium(2+). 26 / 26
| 15 11
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"Expression of the a1D subunit alone, or coexpression with the a26 subunit, did not elicit functional Ca 2+ channel activity."
1309651
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"It can be stated that the mechanism of neurodegeneration in SCA6 is associated with cytoplasmic aggregations of the alpha-1A calcium channel protein caused by a small CAG repeat and polyglutamine expansion in CACNA1A."
18568057
sparser
"The higher synaptic depolarization in sector II than in sector I resulted in a stronger voltage-dependent activation of Ca channels in the former than in the latter (Figure xref )."
28955206
sparser
"The accessory α 2 δ-1 subunit is known to facilitate Ca V 1.2 voltage-dependent activation, but the underlying mechanism is unknown."
27481713
sparser
"These results demonstrate that BHQ inhibits voltage-dependent activation of Ca v 2.1 and has distinct actions on I Ba and I Ca ."
24411734
sparser
"While densin+CaMKII did not affect voltage-dependent activation or facilitation of Ca v 1.3 (data not shown), they significantly increased the amplitude of Ca v 1.3 Ca 2+ currents (I Ca ) during trains of depolarizations (100 Hz, xref )."
20392935
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"FHM Type 1, which accounts for around 50% of all FHM cases, is caused by mutations in the CACNA1A gene encoding the Ca v 2.1 P/Q voltage dependent calcium channel."
27199775
sparser
"As LRRK1 did not significantly alter Ca V 2.1 current density, we hypothesized that LRRK1 would not have any effect on Ca V 2.1 voltage-dependent activation."
27242426
sparser
"We found that CaMKII had no effect on voltage-dependent activation of Ca v 1.3 Ba 2+ currents (I Ba )."
20392935
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"The present study indicates that the mechanism of neurodegeneration in SCA6 is associated with cytoplasmic aggregations of the [alpha] 1A calcium channel protein caused by a small CAG repeat and polyglutamine expansion in CACNA1A."
10369863
sparser
"We conclude that BHQ stabilizes the opening and weakens voltage-dependent activation of Ca v 2.1, which causes slower tail currents and a reduction in the steady- state current, respectively."
24411734
sparser
"Also of note, mild depolarization of the sperm membrane by addition of high K + (60mM) failed to stimulate Ca 2+ transients ( xref ), further suggesting that in sperm, Ca V 2.3 voltage dependent activation is strongly modulated by its lipid environment."
24525187
sparser
"Their study about the functional consequences of ΔF1502 on Ca V 2.1 channel function in Xenopus oocytes using Ba 2+ as the charge carrier (instead of the physiological permeant ion Ca 2+ ), revealed: 1) an ~ 11 mV hyperpolarizing shift in Ca V 2.1 voltage-dependent activation, 2) a 30% decrease in Ba 2+ current density at high depolarizing voltages, 3) a shift in the voltage dependence of steady-state inactivation to hyperpolarizing voltages by ~ 14 mV, and 4) a slightly slower recovery from channel inactivation."
26716990
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"Discussion Distinct Neuronal Call Channel Subunits Comprise a Novel DHP Sensitive Subtype Our results demonstrate that the a, p subunit mediates DHP- sensitive, high voltage activated, long lasting Ca 2+ channel activity."
1309651
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"The CACNA1A (Cav2.1), coding the alpha 1A subunit protein, which mediates the entry of calcium ions into excitable cells."
24847307
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"The a, subunit (a, p) directs the recombinant expression of a dihydropyridine sensitive L-type Ca 2+ channel when coexpressed with the P ([32) and the a2 (a2n) subunits in Xenopus oocytes."
1309651
sparser
"Phosphorylation of S1198 (human α 1 3.2) negatively shifts voltage-dependent activation of Ca v 3.2 channels in HEK293 cells."
22223119
sparser
"To directly verify that the documented hyperpolarizing shift in the steady-state voltage-dependent activation of Ca v 1.3 compared to Ca v 1.2 L-type Ca 2+ channel contributes importantly to the observed decrease in the AV node firing frequency in the null mutant mice, we generated computer modeling to directly assess the effect of Ca v 1.2 and Ca v 1.3 currents on the properties and characteristics of spontaneous APs of mouse AV node cells."
20951705
sparser
"It has been recently reported that BHQ in vitro inhibits Ca V 2.1 voltage-dependent activation, thereby ameliorating gating defects and synaptic transmission due to S218L mutation xref ."
26032020
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"In contrast, a third a, subunit gene, expressed in rabbit brain, directs the synthesis of Ca 2+ channels that are insensitive to both DHPs and w-conotoxin GVIA ((o-CgTx) when coexpressed with the rabbit skeletal muscle a2 and p subunits in Xenopus oocytes (Mori et al., 1991)."
1309651
sparser
"Thus, 2,50-di(tertbutyl)-1,4,-benzohydroquinone (BHQ), a synthetic phenolic compound that inhibits sarcoendoplasmic Ca 2+ ATPases (SERCAs) and with pro-oxidant properties, can also inhibit Ca V 2.1 voltage-dependent activation to ameliorate gating defects in the channel and subsequently prevent synaptic transmission problems produced by the S218L CACNA1A mutation causing a severe form of FHM with slowly progressive cerebellar ataxia and atrophy in humans [ xref ]."
26716990
sparser
"The S218L mutation enhances voltage-dependent activation of Ca v 2.1, which augments excitatory transmission in S218L knock-in mice ( xref ; xref ; xref )."
24411734
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"Familial hemiplegic migraine type 1 (FHM1) is caused by mutations in the CACNA1A gene, encoding neuronal presynaptic Ca (V) 2.1 (P/Q-type) Ca (2+) channels."
20631222
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"Two different targeted Cacna1a disruptions that completely abolish Ca V 2.1 activity result in a severe motor disorder that is reminiscent of generalized dystonia in humans [XREF_BIBR, XREF_BIBR]."
22136648
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"FHM Type 1, which accounts for around 50% of all FHM cases, is caused by mutations in the CACNA1A gene encoding the Ca v 2.1 P/Q voltage dependent calcium channel."
27199775
sparser
"The voltage-dependent activation of Ca(v)1.2 (alpha(1C)) versus Ca(v)1.3 Ca(2+) channel subunits was directly compared by using a heterologous expression system without beta coexpression."
12016264
Mutated CACNA1A activates calcium(2+). 5 / 5
| 5
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"However, little is known about how ataxia can be caused by CACNA1A mutations that increase the Ca (2+) influx, such as the S218L missense mutation."
23115190
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"CACNA1A mutations produce gain-of-function of the Ca V 2.1 channel and result in increased neurotransmitter release from cortical neurons [XREF_BIBR]."
22030984
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"Largely based on work in the ataxic mouse mutant tottering (which carries a mutation of the Cacna1a gene of the P/Q voltage activated calcium channel), 4-AP is hypothesized to function by enhancing excitability or rhythmicity of floccular Purkinje cells."
23451282
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"The Ca (2+) channelopathies caused by mutations of the CACNA1A gene that encodes the pore forming subunit of the human Cav2.1 (P/Q-type) voltage gated Ca (2+) channel include episodic ataxia type 2 (EA2)."
25855180
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"Although hemiplegic migraine (HM) is linked to CACNA1A mutations that enhance Ca V 2.1 channel activity and EA2, on the contrary, is associated to loss-of-function mutations, symptomatology overlap of HM, EA2 and SCA6 are well recognized at the clinical level."
26716990
CACNA1A inhibits calcium(2+).
| 25 5
CACNA1A inhibits calcium(2+). 29 / 29
| 25 4
sparser
"Remarkably, the invertebrate LCa(v)2 channel from the pond snail, Lymnaea stagnalis, does not bear any of the hallmarks of mammalian, voltage-dependent G-protein inhibition of Ca(v)2.2."
20511524
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"XREF_BIBR - XREF_BIBR Therefore, it may be that Cacna1a LOF mutations disrupting Ca V 2.1 channels contribute to the development of epilepsy through their impact on cortical interneuron function."
23595603
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"Genetic deletion of the Cacna1a gene in cortical layer VI neurons enhances T-type Ca 2+ currents in thalamic relay and nRT neurons, thereby generating synchronous SWDs that are inhibited by ethosuximide [XREF_BIBR]."
28290248
sparser
"Ca(v)1.4 voltage-dependent inactivation is slow and Ca2+-dependent inactivation (CDI) is absent."
16921373
sparser
"All of the known beta subunits (beta1-beta5) produced voltage-dependent inhibition of alpha(1B) Ca channels, depending on the gamma subunit found in the heterodimer. beta1-beta4 subunits inhibited Ca channels when paired with gamma1-gamma3."
11007869
sparser
"The voltage-dependent inhibition of type N Ca channels is also thought to be mediated by the direct interaction of Gβγ with a channel subunit ."
11988217
sparser
"We found that roscovitine, a compound that increases the voltage-dependent inactivation of Ca(V)1.2 (refs 6-8), restored the electrical and Ca(2+) signalling properties of cardiomyocytes from Timothy syndrome patients."
21307850
sparser
"Voltage-dependent inactivation of Ca channels is an important mechanism of regulation of Ca 2+ entry during repetitive stimulation."
9607938
sparser
"The TS mutation causes loss of normal voltage-dependent inactivation of Ca(V)1.2 current (I(Ca))."
19001023
sparser
"Simulations show that slowing the voltage-dependent inactivation of Ca current can result in an earlier onset and larger areas of 2 : 1 conduction block [ xref ]."
25815342
sparser
"Here, Yang et al. demonstrate that D3 dopamine receptors regulate AIS Ca V 3 channels through a non-canonical, arrestin-dependent mechanism, suppressing AIS excitability by hyperpolarizing Ca V 3 voltage-dependent inactivation."
27452469
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"In spite of a resemblance between voltage-dependent inactivation of Ca channels and the so-called slow or C-type inactivation found in the whole superfamily of voltage-gated channels, the structural underpinnings of this process have yet to be identified in Ca channels."
9607938
sparser
"This seems to be a common, although not ubiquitous, feature of “voltage-dependent” inactivation of Ca, Na, and now K channels."
9545040
sparser
"Ca 2+ /CaM-dependent protein kinase II (CaMKII) binds to the C-termini of Ca V 1.2 ( xref ; xref ) and Ca V 2.1 ( xref ) and plays a role in Ca V 1.2 ( xref ) and Ca V 2.1 ( xref ) CDF, as well as in Ca V 2.1 voltage-dependent inactivation ( xref )."
18940602
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"It is assumed that polyglutamine repeats in CACNA1A effects Ca 2+ channel to reduce Ca 2+ influx, leading to eventually cell death [XREF_BIBR]."
23331413
sparser
"Previous work has shown that voltage dependent slow inactivation of Ca v 1.2 channels is mediated by hydrophobic residues in the cytoplasmic end of the S6 transmembrane helices of domains I-IV xref , xref , xref ."
18464914
sparser
"Here, we studied the effects of Mg i on voltage-dependent inactivation (VDI) of Ca v 1.2 channels using Na + as permeant ion to eliminate the effects of permeant divalent cations that engage the Ca 2+ -dependent inactivation process."
19596806
sparser
"The main finding of this study is that voltage-dependent inactivation of heterologously expressed cardiac Ca channels is associated with a large negative shift in the voltage dependence of their charge movement."
9607938
sparser
"Initially, TS was thought to arise from a single recurrent mutation, G406R, in the alternatively spliced CACNA1C exon 8a that accounts for ≈20% of the Ca v 1.2 mRNA transcripts in the heart and brain and encodes the distal portion of the domain I transmembrane segment 6 (IS6) known to play a critical role in the voltage-dependent inactivation (VDI) of Ca v 1.2 ( xref ). xref – xref However, shortly after the elucidation of the molecular basis of typical TS now referred to as type I TS (TS1), 2 cases of atypical or type II TS (TS2) were reported in the literature. xref Interestingly, both cases were characterized by extreme QT prolongation (average ≈640 ms) complicated by multiple episodes of cardiac arrest in the absence of syndictyly and harbored de novo mutations in the CACNA1C exon 8–containing heart- and brain-predominant Ca v 1.2 splice variant. xref Interestingly, the exon 8 CACNA1C-G406R–positive TS2 proband displayed severe neurodevelopmental delay, craniofacial/odontic abnormalities, and possible nemaline skeletal myopathy during the first few months of life, whereas the exon 8 CACNA1C-G402S–positive TS2 proband seemed developmentally normal until suffering an out-of-hospital cardiac arrest at age 4. xref It was postulated initially that the lack of syndactyly and the potentially more severe neurological/cardiac phenotypes anecdotally observed in TS2 versus TS1 were likely secondary to the differential tissue-specific expression of exon 8– and exon 8a–containing Ca v 1.2 splice variants. xref Although this is likely the case for exon 8 G406R–mediated TS2, the recent identification of exon 8 G402S in an otherwise developmentally normal adolescent woman with borderline QT prolongation who presented with an out-of-hospital cardiac arrest xref coupled with the normal development of the initial G402S-positive TS2 proband before his first cardiac arrest xref suggest that (1) CACNA1C-G402S results in a milder clinical phenotype more akin to nonsyndromic LQTS and (2) the neurodevelopmental sequelae observed in the initial CACNA1C-G402S–positive TS2 proband are more likely secondary to arrhythmia-induced anoxic brain injury than underlying CACNAlC -mediated developmental delay."
27390209
sparser
"Although a role for CaBP2 in suppressing voltage-dependent inactivation of Ca v 1.3 channels in IHCs of CaBP2 LacZ/LacZ mice has been demonstrated ( Picher et al., 2017 ), the function of CaBP2 in OHCs remains to be elucidated."
29661613
sparser
"On the other hand, there is an important distinction between voltage-dependent inactivation of Ca channels and slow inactivation of Na and K channels."
9607938
sparser
"Molecular genetic studies have revealed that TS patients have mutations with a Gly to Arg substitution at position 406 (G406R) of Ca v 1.2 in the CACNA1C gene, which results in “near-complete” elimination of voltage-dependent inactivation (VDI) of Ca v 1.2 (gain of function). xref , xref Electrophysiological studies have illustrated that G406R-mutated Ca v 1.2 is inactivated at a slow rate xref alongside a high probability of undergoing coordinated openings and closings (coupled gating). xref "
23837003
sparser
"We thereby propose that the NT inhibitory module is indeed central to the voltage-dependent G protein inhibition of N-type Ca channels."
15953418
sparser
"Here, we found that D3Rs altered Ca V 3 voltage dependent inactivation, effectively blocking a major fraction of Ca V 3 channels in the AIS at resting membrane potentials."
27452469
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"The much faster voltage-dependent inactivation of vertebrate Ca v 2 channels has been attributed to the more helical, and rigid proximal linker (PL) between the inactivation gate of the transmembrane segment 6 (S6) helix of domain I and the AID sequence for Ca v β subunit binding xref – xref ."
24690951
sparser
"Because clear modal separation characterizes slow (C-type) inactivation of Na and K channels, this observation establishes the nature of voltage-dependent inactivation of L-type Ca channels as slow or C-type."
9607938
sparser
"AGS1 and Rhes reduced basal current densities and triggered tonic voltage-dependent (VD) inhibition of Ca(V)2.2."
18815223
sparser
"To test potential therapies, the researchers supplied Roscovitine, a cycline-dependent kinase inhibitor shown to increase voltage-dependent inactivation of Ca v 1.2 channel, and demonstrated that many of these abnormal characteristics were rescued."
30988697
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"Recently, we reported that a selective Cacna1a gene deletion in cortical layer VI pyramidal cells, which innervate thalamic relay neurons and reticular thalamic neurons, caused upregulation of T-type calcium current in thalamic relay neurons and resulted in absence epilepsy in mice 59, suggesting that impaired cortical excitatory input to thalamic regions may cause rebound burst of thalamocortical relay neurons and leads to thalamocortical hyper-synchronous oscillations as may be the case for ethosuximide sensitive absence like seizures in Scn2a deficient mice."
30175250
Mutated CACNA1A inhibits calcium(2+). 1 / 1
| 1
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"As a regulator of the formation of P/Q-type calcium channel, CACNA1A mutation can weaken the Cav2.1 function, decrease the Ca 2+ influx, and lead to abnormal function of the P/Q-type calcium channel, which causes abnormality of transmitter release and influences the development of Purkinje fiber and granulosa cells, finally triggering neurological diseases [XREF_BIBR - XREF_BIBR]."
30710491
CACNA1A affects sodium atom
| 74
CACNA1A inhibits sodium atom.
| 38
CACNA1A inhibits sodium atom. 38 / 38
| 38
sparser
"In accordance with the previous reports, the voltage-dependent activation and inactivation of Na v 1.2α were not affected by the PKA regulation xref , which held to be true for the case of Na v 1.2α co-expression with the β1 subunit as well."
24430351
sparser
"Voltage-dependent activation or inactivation of sodium channels was unchanged ( xref )."
21463282
sparser
"As such, early studies hypothesized that CaM and/or the channel vestigial EF hand segment might modulate particular attributes of Na channel voltage-dependent inactivation [ xref , xref ]."
25966688
sparser
"Then, acute reduction in neuronal activity occurs, which arises from voltage-dependent inactivation of sodium channels, while longer-term inhibition of activity occurs in response to the associated rise in intracellular Ca 2+ and associated calcium dependent processes [ xref ]."
20021438
sparser
"Voltage-dependent inactivation of TTX-R Na(+) channels in these neurons was shifted to hyperpolarized potentials by 4 mV."
15120592
sparser
"These data are consistent with a phosphorylation-dependent control of back-propagation during trains of action potentials, attributable mainly to an increase in the time constant of recovery from voltage-dependent inactivation of dendritic Na(+) channels."
21209358
sparser
"In the current-clamp mode, constant currents (up to 0.25 nA) were applied to set the resting membrane potential between −90 and −100 mV and thus to remove voltage-dependent inactivation of the sodium channels."
12941379
sparser
"Experimental data revealed that A1180V channels exhibited a negative transform of voltage-dependent inactivation of the cardiac sodium channels, which lead to a rate-dependent sodium current reduction, and a moderate increase in late sodium current."
24227891
sparser
"This nonlinear modulation of BmK AS could also be observed on voltage-dependent fast and slow inactivation of Na v 1.2α, in which the inactivation curves were both negatively shifted by 1 nM or 100 nM BmK AS but not by 10 nM BmK AS."
24430351
sparser
"Then, acute reduction in neuronal activity occurs, which arises from voltage-dependent inactivation of sodium channels, while longer-term inhibition of activity occurs in response to the associated rise in intracellular Ca2 + and associated calcium dependent processes ( xref and xref )."
21256210
sparser
"Filament breakup was due to SAC recruitment in regions of high fiber stretch (away from the spiral core), resulting in voltage-dependent inactivation of sodium channels there, a mechanism for breakup that is different from other known mechanisms for wavebreak such as restitution (Garfinkel et al., xref )."
21886622
sparser
"This is an important issue to address because plateau potentials can lead to spike failures by impairing the voltage-dependent de-inactivation of host-cell sodium channels; ChETA mutations have previously been shown to virtually eliminate the plateau potential in fast-spiking interneurons xref , but left unclear the best strategy to use for pyramidal neurons because those ChETAs did not give rise to strong photocurrents in cultured pyramidal cells ( xref )."
22179551
sparser
"The biophysical origin of such effect is believed to be the differential kinetics of the voltage-dependent activation and inactivation of sodium and potassium channels on the neuron membrane (for further details, see xref )."
21408148
sparser
"These results showed that both mexiletine and lidocaine significantly caused the shift of voltage-dependent inactivation of Na v 1.5 or Na v 1.7 to the hyperpolarized direction, reflecting a shift in equilibrium from resting to inactivated states, and thus providing a basis for suppressing repetitive firing."
26068619
sparser
"The mutations also disabled FHF modulation of voltage-dependent fast inactivation of sodium channels in neuronal cells."
19406745
sparser
"When g(K,ATP) is lower than 72 nS, the model enters a stable depolarised state, and firing of action potentials is inhibited due to voltage-dependent inactivation of the Na(+) and T-type Ca(2+) currents."
19669464
sparser
"Consequently, the amplitude of APs reduces due to voltage-dependent inactivation of Na v channels."
27044683
sparser
"The sodium current showed voltage-dependent activation and inactivation."
2445391
sparser
"In this study, the effects of BmK AS, a sodium channel-specific modulator from Chinese scorpion Buthus martensi Karsch, on the voltage-dependent activation and inactivation of Na v 1.2 were examined before and after PKA activation."
24430351
sparser
"Cold typically inhibits neuronal excitability, partly by increasing voltage-dependent inactivation of voltage-gated sodium (Nav) channels."
25622298
sparser
"Therefore, the anticonvulsant potentiation observed with the FBM+VPA combination is more likely to be due to the additive effect of the voltage-dependent Na + inhibition of the two drugs than to an increase in GABAergic tone."
12798671
sparser
"Together with the electrophysiological findings showing that the intrinsic properties, such as voltage-dependent activation and inactivation of Nav1.8 sodium channels, remained unchanged after the inoculation of tumor cells, the increased expression of Nav1.8 on the cell membrane provides a possible explanation for the enhanced density of Nav1.8- mediated sodium current in the DRG neurons of MRMT-1-treated rats, which actually represents the functional upregulation of Nav1.8 sodium channels in the DRG neurons of bone cancer rats."
25503076
sparser
"Loss of Na(V)1.1 did not change voltage-dependent activation or inactivation of sodium channels in hippocampal neurons."
16921370
sparser
"The voltage-dependent steady-state inactivation of DRG-type sodium channels was determined by eliciting 400-ms conditioning pulses to voltages between −140 and 0 mV in 10 mV increments followed by a 80 ms standard test pulse to 0 mV."
26491429
sparser
"In contrast with activation, the hyperpolarized shift of voltage-dependent inactivation of Na v 1.2α by BmK AS could be reproduced on Na v 1.2 (α + β1)."
24430351
sparser
"The FB model anesthetics have qualitatively similar effects on Na v as clinically used halogenated anesthetics such as ISO, sevoflurane, and desflurane, all of which produce voltage-dependent inhibition of Na v function ( xref ; xref ; xref ; xref )."
25385786
sparser
"We found that differentiating hiPSC-derived neuronal cells in co-cultures progressively displayed more negative resting membrane potentials to a level sufficient to remove voltage-dependent inactivation of sodium channels and to fire repetitive action potentials."
27819315
sparser
"Filament breakup was due to SAC recruitment in regions of high fiber stretch (away from the spiral core), resulting in voltage-dependent inactivation of sodium channels there, a mechanism for breakup that is different from other known mechanisms for wavebreak such as restitution. xref – xref The simulations results thus provided an alternative explanation for the degeneration of VT into VF."
21212393
sparser
"LQT3 is caused by a gain of function variation in SCN5A, resulting in decreased voltage dependent inactivation of sodium channels."
24632794
sparser
"These findings suggest that the primary electrophysiological effect of Ro 22-9194 as an antiarrhythmicagent is, like moricizine, a use- and voltage-dependent inhibition of sodium channels."
7712017
sparser
"Loss of Na V 1.1 did not change voltage-dependent activation or inactivation of sodium channels in hippocampal neurons ( xref )."
19005038
sparser
"We further identified that changes in neuronal currents were originated from temperature-induced shifts in voltage-dependent activation and inactivation of Na and K channels."
19034696
sparser
"Voltage-dependent activation and inactivation of Na v 1.4, but not Na v 1.5, shifts when expressed in cells incapable of sialylation, indicating not all VGSCs are affected equally ( xref )."
27252364
sparser
"As expected, DCJW caused a slowly developing, voltage-dependent inhibition of Na v 1.4 current ( xref )."
27993108
sparser
"This was shown to be due to a modulation of the voltage-dependent inactivation of both sodium (INa) and calcium (ICa) currents."
8901621
sparser
"These findings suggest that the primary electrophysiological effect of SD-3212 is a use- and voltage-dependent inhibition of sodium channels."
7881749
sparser
"The time course of recovery from voltage-dependent inactivation of sodium current during conditioned block was both slowed and exhibited voltage dependence."
6319681
sparser
"Subsequently, Na v 1.8 expressed in mammalian neuronal cells revealed concentration- and voltage-dependent inhibition of Na v 1.8 by clinically relevant concentrations of isoflurane similar to other subtypes (Herold et al., xref ; Figure xref A, upper panel)."
22479247
CACNA1A activates sodium atom.
| 36
CACNA1A activates sodium atom. 36 / 36
| 36
sparser
"Distinctively different with the case observed in Na v 1.2α, BmK AS could move the voltage dependent activation of Na v 1.2 (α + β1) towards depolarization in a linear dose-dependent way ( xref , right, Pre AS): Prominent for 100 nM ( Δ V 1/2 = 6.43 mV, P < 0.001) and 10 nM ( Δ V 1/2 = 6.03 mV, P < 0.005), but less significant for 1 nM ( Δ V 1/2 = 2.05 mV, P < 0.05) ( xref and xref )."
24430351
sparser
"The transmembrane segments of the conserved homologous domains were shown (by site-directed mutagenesis and expression studies) to be involved in the voltage-dependent activation of sodium channels and cation transport [56–58] ."
11086217
sparser
"The S4 segments serve as voltage sensors to initiate the voltage-dependent activation of sodium channels by moving outward under the influence of the electric field, thereby imposing a conformational change leading to channel activation [ xref ]."
29186022
sparser
"Loss of Na(V)1.1 did not change voltage-dependent activation or inactivation of sodium channels in hippocampal neurons."
16921370
sparser
"We further identified that changes in neuronal currents were originated from temperature-induced shifts in voltage-dependent activation and inactivation of Na and K channels."
19034696
sparser
"The voltage-dependent activation of sodium channels is essential for the generation of the upstroke phase of the action potential in most excitable cells."
9379171
sparser
"Further, we observed no difference in I Na voltage-dependent activation, steady-state voltage-dependent inactivation, or time-dependent recovery between WT and B56α KO myocytes ( xref ; p=N.S.)."
30602331
sparser
"However, patch clamp recordings and Na + imaging studies of the AIS suggest that the density of functional Na + channels, while higher in the AIS than in the soma, may not be as high as suggested from immunohistochemistry, and that the lower threshold for AP initiation results from a hyperpolarized shift in I Na voltage-dependent activation and the presence of I NaP ( xref ; xref ; xref )."
23216577
sparser
"Similar to the case of chimera ChD3, in the presence of 2 µM BmK IT2 and a 25 ms prepulse, the voltage-dependent activation of L(Dm)Na v 1.2 displayed a mild but significant shift with ΔV 1/2 of about −5 mV (p<0.05, n = 8, xref and xref )."
21264295
sparser
"Thus, PKA phosphorylation largely attenuated the effect of BmK AS on voltage-dependent activation of Na v 1.2 either co-expressed with β1 subunit or not."
24430351
sparser
"In accordance with the previous reports, the voltage-dependent activation and inactivation of Na v 1.2α were not affected by the PKA regulation xref , which held to be true for the case of Na v 1.2α co-expression with the β1 subunit as well."
24430351
sparser
"The sodium current showed voltage-dependent activation and inactivation."
2445391
sparser
"xref describes the effects of the β1 subunit on the voltage-dependent activation of Na v 1.6 sodium channels expressed in HEK293 cells. xref shows families of sodium currents, recorded using the indicated pulse protocol, from an individual representative cell expressing rat Na v 1.6 sodium channels and current – voltage plot of the peak transient sodium currents in these traces. xref shows sodium current traces and current – voltage relationships from an individual representative cell expressing Na v 1.6β1 sodium channels. xref shows conductance – voltage plots of data obtained from multiple cells expressing rat Na v 1.6 sodium channels either in the absence or presence of the β1 subunit, and xref summarizes the statistical analysis of these data."
24404202
sparser
"Loss of Na V 1.1 did not change voltage-dependent activation or inactivation of sodium channels in hippocampal neurons ( xref )."
19005038
sparser
"Voltage-dependent activation or inactivation of sodium channels was unchanged ( xref )."
21463282
sparser
"Persistent inflammation leading to nociception also induced time-dependent changes in Aβ-fiber neuron excitability by shifting the voltage-dependent activation of Na v 1.8 in the hyperpolarizing direction, thus decreasing the current threshold for triggering action potentials."
24606981
sparser
"While the voltage-dependent activation of Na v 1.5 or Na v 1.7 was not affected by mexiletine and lidocaine, the steady-state fast and slow inactivation of Na v 1.5 and Na v 1.7 were significantly shifted to hyperpolarized direction by either mexiletine or lidocaine in dose-dependent manner."
26068619
sparser
"We found that: (1) some chemical mediators (e.g., adenosine 5'-triphosphate) produce a reduction or loss of superexcitability together with increased axonal excitability, indicating membrane depolarization; (2) blockade of axonal hyperpolarization-activated (Ih) currents produces an enhancement of superexcitability together with a decreased excitability, indicating membrane hyperpolarization; and (3) application of calcium produces an increase in membrane threshold without an alteration in superexcitability, indicating a non-specific increase in surface charge and a change in the voltage-dependent activation of sodium channels."
17487863
sparser
"The biophysical origin of such effect is believed to be the differential kinetics of the voltage-dependent activation and inactivation of sodium and potassium channels on the neuron membrane (for further details, see xref )."
21408148
sparser
"To examine the effects of mexiletine and lidocaine on channel gating properties, we started recording of voltage-dependent activation of Na v 1.5 and Na v 1.7 channels stably expressed in HEK293 cells."
26068619
sparser
"Their actions are facilitated by the micro-agatoxins, which shift voltage-dependent activation of neuronal sodium channels to more negative potentials, causing spontaneous transmitter release and repetitive action potentials."
15066410
sparser
"Despite the complete removal of inactivation by NBA, the voltage-dependent activation of sodium channels remains unaltered as determined by (a) sodium current turn-on kinetics, (b) sodium tail current kinetics, (c) voltage dependence of steady-state activation, and (d) sensitivity of sodium channels to external calcium concentration."
650167
sparser
"The ionic conductances that are modulated by cholinergic receptor activation were assessed in voltage clamp experiments in the presence of TTX (0.5 µM) and ZD7288 (50 µM) to block voltage-dependent activation of sodium channels and the hyperpolarization-activated current I h , respectively."
23520542
sparser
"Considering the fact that there may be an offset in I-V curve due to the variation in reversal potential (Vrev), the G-V relationship was further assessed to analyze the modulation of BmK AS on voltage-dependent activation of Na v 1.2 before and after PKA phosphorylation."
24430351
sparser
"Together with the electrophysiological findings showing that the intrinsic properties, such as voltage-dependent activation and inactivation of Nav1.8 sodium channels, remained unchanged after the inoculation of tumor cells, the increased expression of Nav1.8 on the cell membrane provides a possible explanation for the enhanced density of Nav1.8- mediated sodium current in the DRG neurons of MRMT-1-treated rats, which actually represents the functional upregulation of Nav1.8 sodium channels in the DRG neurons of bone cancer rats."
25503076
sparser
"RTX-VII negatively shifted the voltage-dependent activation of the Na v 1.3/1.5 DII chimera and increased the I NaT at voltages ranging from −50 mV to 5 mV ( xref )."
25784299
sparser
"The parameters m , n and h are dynamic variables that describe the voltage-dependent activation of sodium and potassium channels, and the sodium channel deactivation after spike initiation, respectively."
30158188
sparser
"As shown in xref , myh10 coexpression hyperpolarized voltage-dependent activation of Na v 1.8 channels."
29956586
sparser
"When electrotonic propagation from the neighboring cells depolarizes the cell membrane to reach the threshold for Na + channel voltage-dependent activation, a large number of channels open giving rise to a huge depolarizing current (∼20–30 nA/pF at peak), which determines the upstroke phase of the AP."
24689024
sparser
"In this study, the effects of BmK AS, a sodium channel-specific modulator from Chinese scorpion Buthus martensi Karsch, on the voltage-dependent activation and inactivation of Na v 1.2 were examined before and after PKA activation."
24430351
sparser
"The voltage dependent activation of deglycosylated Na v 1.2 was significantly shifted to more negative direction by BmK I, contrary to the little effects on the glycosylated ones."
22829817
sparser
"Voltage-dependent activation of sodium channels depends on movement of “electrically charged particles” across the cell membrane through the transmembrane electric field [ xref ]."
28589518
sparser
"Bennett [30] suggested that a glycosylated structure is important in the voltage-dependent activation of cardiac sodium channels that in turn may alter propagation of the action potential and hence result in myocardial contraction."
12676541
sparser
"These results support the hypothesis that veratridine, in small concentrations, induces a slow voltage-dependent activation of TTX-sensitive sodium channels, independent of the fast activating and inactivating sodium channels involved in action potential generation."
1849251
sparser
"Voltage-dependent activation and inactivation of Na v 1.4, but not Na v 1.5, shifts when expressed in cells incapable of sialylation, indicating not all VGSCs are affected equally ( xref )."
27252364
sparser
"Together the data show that rSkM1 and hH1 activation mechanisms are different and are the first to suggest a role for a cytoplasmic structure in the voltage-dependent activation of cardiac sodium channels."
10585922
Calcium_channels affects CACNA1A
| 43
Calcium_channels activates CACNA1A.
| 20
Calcium_channels activates CACNA1A. 20 / 20
| 20
sparser
"Somatic heterozygous mutations in the genes KCNJ5 coding for the potassium channel GIRK4, ATP1A1 coding for the α1 subunit of the Na + /K + -ATPase, ATP2B3 coding for the plasma membrane Ca 2+ -ATPase, type 3 PMCA3, and CACNA1D encoding the Cav1.3 voltage dependent calcium channel were identified in approximately 50% of APA. xref - xref These mutations are responsible for chronic zona glomerulosa cell membrane depolarization ( KCNJ5 and ATP1A1 mutations) leading to opening of voltage-dependent calcium channels, for impaired intracellular calcium recycling ( ATP2B3 mutations), or voltage-dependent calcium channel activation and opening at lower voltages ( CACNA1D mutations). xref – xref All these genetic abnormalities converge towards an increase in intracellular calcium concentration and activation of calcium signaling, which plays a central role in the regulation of aldosterone production, in particular by increasing the expression of CYP11B2 encoding aldosterone synthase."
26351028
sparser
"It triggers potassium ions (K + ) efflux, which prevents voltage-dependent calcium channel activation, leading to a decrease of the intracellular calcium concentration and relaxation of vascular SMC [ xref ]."
25387998
sparser
"KCNJ5 and ATP1A1 mutations are responsible for chronic zona glomerulosa cell membrane depolarization leading to opening of voltage-dependent calcium channels, while ATP2B3 mutations affect intracellular calcium recycling and CACNA1D mutations lead to voltage-dependent calcium channel activation and opening at lower voltages ( xref , xref , xref , xref )."
27729216
sparser
"While these putative functional NMDA receptors are generally assumed to be at axonal locations, the existence of presynaptic, axonal NMDA receptors has been challenged by the discovery that somatodendritic NMDA receptor activation can affect axonal Ca 2+ levels through voltage-dependent calcium channel activation, at least in cerebellar stellate cells (Christie and Jahr, xref )."
21423504
sparser
"These authors found that neuronal activity such as NMDA receptor-dependent calcium influx or voltage-dependent calcium channel activation resulted in either receptor disassembly or clustering, respectively, thus underscoring a role for receptor stimulation in scaffolding protein turnover."
15006485
sparser
"The authors show that BDNF release from cultured cortical cells is dependent on both AMPAR and voltage-dependent calcium channel activation and that BDNF dose-dependently increases extracellular signal-regulated kinase 1/2 phosphorylation via a tropomyosin receptor kinase B–dependent mechanism."
29173709
sparser
"The above results show that spontaneous Ca ++ oscillations in OLs are generated in response to voltage-dependent calcium channel activation."
19458236
sparser
"Conversely, when K channels close, intracellular free Ca 2+ increases as a result of voltage-dependent calcium channel activation and vessels constrict."
19934370
sparser
"Toxic-dose bupivacaine-induced relaxation appears to be partially associated with the inhibition of voltage-dependent calcium channel activated by phenylephrine in endothelium-denuded rat aortas."
25031808
sparser
"Studies in primary neuronal cultures provide direct evidence that ketamine increases BDNF release in an activity dependent manner that also requires L-type voltage dependent calcium channel (VDCC) activation ( xref )."
29203848
sparser
"Another GWAS (n=2323) observed trending associations (ie, p<0.05, but not genome-wide significance) between CACNA1C variants and both increased sleep latency (p<0.0001) and poorer sleep quality (p<0.0001). xref Another study found no significant association between variants and sleep latency (n=2034); xref however, a candidate gene study observed associations between CACNA1C variants and poor sleep quality (p<0.017). xref Furthermore, the rare, homozygous recessive genotype (three of 932 individuals) for this CACNA1C variant was associated with reduced sleep latency (p<0.005) and higher reports of depressive symptoms (p<0.001). xref CACNA1C encodes an L-type voltage-dependent calcium channel activated by the wake-promoting neuropeptide orexin, and has been implicated in depression, bipolar disorder, schizophrenia, and one small (n=602) candidate gene study of narcolepsy ( xref , xref )."
28102151
sparser
"It has been hypothesized that L-type voltage-dependent calcium channel activation or locally generated, spatially restricted dendritic spikes in proximal dendrites could contribute to postsynaptic depolarization and calcium entry, which shifts the balance to LTP rather than LTD in this region (Golding et al., xref ; Parvez et al., xref )."
25767434
sparser
"Induced rather than basal VEGF release in RPE is thought to be controlled by different mechanisms, including voltage-dependent calcium channel (VDCC) activation and mitogen-activated protein kinases."
21566137
sparser
"Specifically, post-synaptic eCB synthesis, initiated via voltage-dependent calcium channel activation or G-protein coupled receptor (GPCR)-dependent mechanisms, results in release and diffusion of eCBs into the synaptic cleft ( xref )."
21884761
sparser
"Under these conditions, X-Rhod-5F and Fluo4-FF could detect calcium changes (signal twice that of noise) in the dendrite due to voltage dependent calcium channel activation after single action potentials while with the same criterion GCaMP required 5 action potentials, camgaroo-2, 33, and inverse pericam over 20."
21035686
sparser
"When K + channels close, become dysfunctional, or their expression is down regulated, the cell depolarizes and intracellular Ca 2+ increases as a result of voltage-dependent calcium channel activation."
25245387
sparser
"Third, Ang IV increases Ca 2+ levels via L-type voltage-dependent calcium channel activation, leading to post-synaptic modulations to enhance synaptic transmission and long-term potentiation (LTP) [ xref ]."
29543776
sparser
"Broad spikes are dependent on voltage-dependent calcium channel activation."
26416140
sparser
"In addition to a potential direct contribution to calcium influx, Trpc channels are thought to promote calcium entry by providing a depolarizing stimulus (sodium and calcium currents) for voltage-dependent calcium channel activation and subsequent smooth muscle cell contraction [ xref , xref ]."
28085954
sparser
"SCaTs were observed in the basket terminals at frequencies that were significantly increased after bath application of 10 microm ryanodine and did not depend on P/Q- or N-type voltage-dependent calcium channel activation."
15295030
Calcium_channels binds CACNA1A. 12 / 12
| 12
sparser
"Another possibility is that some mutations uniquely affect Best1’s ability to physically and functionally interact with voltage-dependent calcium channel subunits."
28153808
sparser
"This activity stopped dendritic spine formation via L-type voltage-dependent calcium channel activity and protein synthesis."
29425501
sparser
"Key Words: brain ischemia, nimodipine, 1,4-DHP calcium channel antagonist receptors It is known that binding of 1,4-dihydropyridine (DHP) calcium channel antagonists to voltage dependent calcium channels (VDCC) is dependent on cell membrane polarization and these drugs bind with a much higher affinity to VDCC in depolarized membranes (1,2)."
10755471
sparser
"Perry, D.C., Wei, H., Rosenthal, R.E. and Fiskum, G. (1994) Autoradiographic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral iscbemia/reperfusion."
8877597
sparser
"A membrane pathway for the binding of dihydropyridine calcium channel antagonists to the L-type calcium channel has been proposed by Rhodes and coworkers [23]."
7945438
sparser
"Mutations in the CACNA1A calcium channel subunit gene on chromosome 19 are associated with a wide spectrum of mutation-specific episodic and chronic neurological disorders, including FHM with or without coma."
11409427
sparser
"For example, the light chains of the MT-associated protein 1B (LC1-MAP1B) and MT-associated protein 1A (MAP1A) interact with the presynaptic voltage dependent calcium channel Ca v 2.2 ( xref ; xref )."
27504085
sparser
"Perry, D.C., H, Wei, R.E. Rosenthal and G. Fiskum, 1994, Autoradio- graphic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral ischemia/reperfusion, Brain Res, 657, 65, Shek, J.W.."
8960859
sparser
"As indicated in xref , we also identified SNPs that showed the same direction of effect for schizophrenia and AD+P risk, Notable among these were two intronic SNPs located in CACNA1C , the gene encoding the voltage-dependent L-type calcium channel subunit alpha-1C. Although the genetic mechanism underlying these associations remains an area of active inquiry, xref convergent data suggests that schizophrenia is associated with reduced voltage-dependent calcium channel function. xref – xref How reductions in voltage-dependent calcium channel function may further increase AD+P risk is not known, however, impairments of intracellular Ca 2+ homeostasis are present in AD, and can contribute to synaptic dysfunction and cognitive impairments. xref "
28461698
sparser
"Experiments with recombinant proteins were performed to map synaptic protein interaction sites on the alpha 1A subunit, which forms the pore of the P/Q-type calcium channel."
10212477
sparser
"Epidemiological studies have shown that the use of L-type voltage-dependent calcium channel (L-VDCC) antagonists by patients with cardiovascular conditions is associated with a reduced incidence of AD in [ xref ] and patients treated with the L-VDCC antagonist nimodipine have improved cognitive scores compared to placebo-treated patients [ xref ]."
25888781
sparser
"These data are consistent with the view that aspect of the sleep-altering activity of triazolam involves interaction with voltage-dependent calcium channel activity."
7916912
Calcium_channels binds CACNA1A and LTP. 1 / 1
| 1
sparser
"Last, a voltage-dependent calcium channel-dependent form of LTP in the CA1 could also be reversibly abated by LY294002, raising the possibility that PI3-kinase could be required for the expression of multiple forms of synaptic potentiation."
11978812
Calcium_channels binds CACNA1A and GADD45A. 1 / 1
| 1
sparser
"Focal knockdown of growth arrest and DNA-damage-inducible protein 45β expression attenuated ligation-induced allodynia (n = 7) by reducing the binding of growth arrest and DNA-damage-inducible protein 45β to the voltage-dependent T-type calcium channel 3.2 subunit promoter (n = 6) that decreased expression of and current mediated by the voltage-dependent T-type calcium channel 3.2 subunit (both n = 6)."
28346321
Calcium_channels binds Myosin_complex, CACNA1A, and GTF2B. 1 / 1
| 1
sparser
"Ablation of myosin-IIB in mice is embryonic lethal, and myosin-IIB ( MYH10 ) mutations are thought to be embryonic lethal in humans, as well; however, myosin-IIB function has been associated with the pathogenesis of spinocerebellar ataxia type 6 (SCA6) through associations of myosin-IIB and Cav2.1 calcium channel polyglutamate tracts [ xref ]."
20850431
Calcium_channels binds Voltage_gated_ion_channels, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"Autosomal dominant mutations in the CACNA1A gene, which encodes the voltage-gated P/Q-type calcium channel alpha1 subunit, has also been associated with cerebellar ataxia, vertigo, epilepsy, and schizophrenia (see below) in addition to FHM (Lhatoo et al., xref )."
24312013
Calcium_channels binds CACNA1A, CACNA1B, and CACNA1C. 1 / 1
| 1
sparser
"For instance, association of several voltage-dependent calcium channel genes such as CACNA1C and CACNA1B was reported in large-scale GWAS for BD. xref , xref A pathway analysis of GWAS data suggests enrichment of calcium channel-related pathways among the genes empirically associated with BD. xref Studies of peripheral blood cells have consistently demonstrated altered intracellular calcium signaling in BD. xref , xref Lithium, the first-line therapeutic drug for BD, modulates inositol-mediated pathways xref and thereby regulate calcium ion release from the endoplasmic reticulum. xref When we performed a GO enrichment analysis using DAVID xref , xref by integrating the data of de novo protein-altering mutations in our study, common single-nucleotide polymorphisms associated with BD in a large-scale GWAS xref and rare CNVs implicated in BD xref (total no. of unique input genes=229, see xref for details), ‘calcium signaling pathway (hsa04020)' was the only term significantly enriched after performing correction for multiple testing ( P corrected =6.4 × 10 −3 , Bonferroni correction; note that significant enrichment of ‘calcium signaling pathway (hsa04020)' after correction was not observed when we submitted candidate genes from each study)."
27217147
Calcium_channels binds CACNA1A, CLCN2, TUBB3, and DLL1. 1 / 1
| 1
sparser
"Mutations of gamma-aminobutyric acid receptor alpha1, gamma-aminobutyric acid receptor delta, calcium channel voltage-dependent beta4 subunit and chloride channel 2 gene are associated with juvenile myoclonic epilepsy."
19298753
Calcium_channels binds Myosin_complex, CACNA1A, CC2D2A, and GTF2B. 1 / 1
| 1
sparser
"Ablation of myosin-IIB in mice is embryonic lethal, and myosin-IIB ( MYH10 ) mutations are thought to be embryonic lethal in humans, as well; however, myosin-IIB function has been associated with the pathogenesis of spinocerebellar ataxia type 6 (SCA6) through associations of myosin-IIB and Cav2.1 calcium channel polyglutamate tracts [ xref ]."
20850431
Calcium_channels inhibits CACNA1A.
| 4
Calcium_channels inhibits CACNA1A. 4 / 4
| 4
sparser
"Using calcium indicator dyes we identified a source of calcium for asynchronous release that, under conditions of P/Q type calcium channel inhibition, originated in the axons and branch points and appeared to propagate into the synaptic boutons."
24368731
sparser
"These data suggest that, in addition to an increase in current density, dystrophin-deficiency also generated a reduction in voltage-dependent calcium channel inactivation."
24337461
sparser
"As for facilitation, calcium-dependent STD could implicate calcium binding proteins, that could in turn regulate various processes such as voltage-dependent calcium channel inactivation or recovery of the immediately releasable vesicle pool [ xref , xref , xref , xref ]."
28820903
sparser
"In Timothy syndrome, a “gain of function” mutation in the L-type calcium channel leads to reduced voltage dependent calcium channel inactivation [ xref ]."
26925288
CACNA1A affects buk
| 37
CACNA1A activates buk.
| 36
CACNA1A activates buk. 18 / 18
| 18
sparser
"Interestingly, although experimental data suggest that the TM segments of β1, β2, and β4 subunits similarly localize with the Slo1 VSD, the functional effects of these β subunits on the voltage-dependent activation of BK channels differ (see below)."
22529812
sparser
"The purpose of the present study is to evaluate the ability of a two-tiered allosteric gating mechanism to describe both the Ca 2+ and voltage-dependent activation of BK channels."
10871641
sparser
"As previously described, loss of the BKβ 1 subunit would be expected to decrease Ca 2+ - and voltage-dependent activation of VSM BK channels (Brenner et al., xref ), leading to exaggerated membrane depolarization and smooth muscle contraction."
25202279
sparser
"Single vascular smooth muscle cell patch clamp protocols suggested that adiponectin had a small effect on the voltage dependent activation of BK channels when the cytoplasm of the cell was intact."
28830977
sparser
"Consequently, substitutions in S0 disrupt the voltage-dependent activation of BK channels, underscoring the critical role of S0 in channel function xref ."
25275635
sparser
"Unlike the β1 subunit, the β2 subunit effects on voltage-dependent activation of BK channels are minimal (Orio and Latorre, xref )."
22529812
sparser
"In comparison, the voltage-dependent activation of BK channels has received less attention."
10436003
sparser
"Voltage-dependent activation of BK channels occurs on a millisecond time scale, similar to many purely voltage-gated K + (K v ) channels."
10436003
sparser
"A. Voltage-dependent activation of BK channels."
19099186
sparser
"All four known LRRC proteins (i.e., LRRC26, 38, 52, and 55) have been reported to enhance voltage-dependent activation of BK channels (Yan and Aldrich, xref , xref ), with LRRC26 producing an impressive shift of up to −150 mV."
25202279
sparser
"The voltage-sensitive dye bis-(1, 3-dibutylbarbituric acid) trimethine oxonol [DiBAC4(3)] at submicromalor levels (Morimoto et al., xref ) produced a shift in the voltage-dependence of the BK channel only when β-1 and β-4 subunits were present, whereas saturating concentrations (30 μM), produced huge negative shifts by up to −300 mV in the voltage-dependent activation of BK channels, but this effect was neither dependent on calcium nor the presence of β-subunits (Scornik et al., xref )."
25346695
sparser
"Although distinct mechanisms underlie Ca 2+ - and voltage-dependent activation of BK channels, it is apparent that the G–V relation shifts to more negative voltages with increasing [Ca 2+ ] i ( xref ), while the G-[Ca 2+ ] i dose response curve is altered by increasing voltage to decrease EC 50 and increase the Hill coefficient [ xref ]."
19099186
sparser
"This study examines the functional interaction between Mg 2+ - and voltage-dependent activation of mSlo1 BK channels."
18166624
sparser
"Finally, evidence for the β1 subunit modulating the coupling between the VSD and the activation gate comes from fitting the above data to the HCA model (Horrigan et al., xref ) that describes the allosteric mechanism of voltage-dependent activation of BK channels."
22529812
sparser
"The shortening of APD in +hBKα-transfected cells was reversed by the BK channel inhibitor, IBTX, and by lowering intracellular free Ca 2+ , which is expected to shift the voltage-dependent activation of BK channels to more depolarized potentials [ xref ]."
26091273
sparser
"Although at least 10 µM Ca 2+ was required to bring the midpoint of voltage-dependent activation (V 1/2 ) of both BK 0 and BK SRKR channels into the physiological voltage range, the G-V relationships remained right-shifted when compared with mouse mbr5 channels, a benchmark clone of BK."
24277601
sparser
"The variables of voltage-dependent activation of BK channels calculated from the I-V relationships ( xref ) were fitted to a Boltzmann function ( xref ), and the V 1/2 of the channel activation was 6.6±1.4 mV in control, 10.2±1.7 mV in LDL, and 5.8±1.5 mV in LDL plus MβCD (n = 10 for each group, P  = NS vs. control), suggesting that LDL, like MβCD-cholesterol, reduces BK current without significantly affecting the voltage-dependent activation."
24260325
sparser
"The Core-MT channel provides a tool to study the function of the gating ring in voltage-dependent activation of BK channels."
28196879
CACNA1A activates buk. 18 / 18
| 18
sparser
"As previously described, loss of the BKβ 1 subunit would be expected to decrease Ca 2+ - and voltage-dependent activation of VSM BK channels (Brenner et al., xref ), leading to exaggerated membrane depolarization and smooth muscle contraction."
25202279
sparser
"The shortening of APD in +hBKα-transfected cells was reversed by the BK channel inhibitor, IBTX, and by lowering intracellular free Ca 2+ , which is expected to shift the voltage-dependent activation of BK channels to more depolarized potentials [ xref ]."
26091273
sparser
"Interestingly, although experimental data suggest that the TM segments of β1, β2, and β4 subunits similarly localize with the Slo1 VSD, the functional effects of these β subunits on the voltage-dependent activation of BK channels differ (see below)."
22529812
sparser
"Unlike the β1 subunit, the β2 subunit effects on voltage-dependent activation of BK channels are minimal (Orio and Latorre, xref )."
22529812
sparser
"In comparison, the voltage-dependent activation of BK channels has received less attention."
10436003
sparser
"Single vascular smooth muscle cell patch clamp protocols suggested that adiponectin had a small effect on the voltage dependent activation of BK channels when the cytoplasm of the cell was intact."
28830977
sparser
"Voltage-dependent activation of BK channels occurs on a millisecond time scale, similar to many purely voltage-gated K + (K v ) channels."
10436003
sparser
"Although distinct mechanisms underlie Ca 2+ - and voltage-dependent activation of BK channels, it is apparent that the G–V relation shifts to more negative voltages with increasing [Ca 2+ ] i ( xref ), while the G-[Ca 2+ ] i dose response curve is altered by increasing voltage to decrease EC 50 and increase the Hill coefficient [ xref ]."
19099186
sparser
"This study examines the functional interaction between Mg 2+ - and voltage-dependent activation of mSlo1 BK channels."
18166624
sparser
"Finally, evidence for the β1 subunit modulating the coupling between the VSD and the activation gate comes from fitting the above data to the HCA model (Horrigan et al., xref ) that describes the allosteric mechanism of voltage-dependent activation of BK channels."
22529812
sparser
"The variables of voltage-dependent activation of BK channels calculated from the I-V relationships ( xref ) were fitted to a Boltzmann function ( xref ), and the V 1/2 of the channel activation was 6.6±1.4 mV in control, 10.2±1.7 mV in LDL, and 5.8±1.5 mV in LDL plus MβCD (n = 10 for each group, P  = NS vs. control), suggesting that LDL, like MβCD-cholesterol, reduces BK current without significantly affecting the voltage-dependent activation."
24260325
sparser
"The voltage-sensitive dye bis-(1, 3-dibutylbarbituric acid) trimethine oxonol [DiBAC4(3)] at submicromalor levels (Morimoto et al., xref ) produced a shift in the voltage-dependence of the BK channel only when β-1 and β-4 subunits were present, whereas saturating concentrations (30 μM), produced huge negative shifts by up to −300 mV in the voltage-dependent activation of BK channels, but this effect was neither dependent on calcium nor the presence of β-subunits (Scornik et al., xref )."
25346695
sparser
"Consequently, substitutions in S0 disrupt the voltage-dependent activation of BK channels, underscoring the critical role of S0 in channel function xref ."
25275635
sparser
"A. Voltage-dependent activation of BK channels."
19099186
sparser
"Although at least 10 µM Ca 2+ was required to bring the midpoint of voltage-dependent activation (V 1/2 ) of both BK 0 and BK SRKR channels into the physiological voltage range, the G-V relationships remained right-shifted when compared with mouse mbr5 channels, a benchmark clone of BK."
24277601
sparser
"The purpose of the present study is to evaluate the ability of a two-tiered allosteric gating mechanism to describe both the Ca 2+ and voltage-dependent activation of BK channels."
10871641
sparser
"The Core-MT channel provides a tool to study the function of the gating ring in voltage-dependent activation of BK channels."
28196879
sparser
"All four known LRRC proteins (i.e., LRRC26, 38, 52, and 55) have been reported to enhance voltage-dependent activation of BK channels (Yan and Aldrich, xref , xref ), with LRRC26 producing an impressive shift of up to −150 mV."
25202279
CACNA1A binds buk.
| 1
CACNA1A binds buk and buk. 1 / 1
| 1
sparser
"Direct interaction of Cav2.1 and BK proteins was also found by copurification of these two molecules from rat brain in tandem mass spectrometry ( xref )."
23426693
CACNA1A affects Calcium_channels
| 1 29
Calcium_channels binds CACNA1A. 12 / 12
| 12
sparser
"Another possibility is that some mutations uniquely affect Best1’s ability to physically and functionally interact with voltage-dependent calcium channel subunits."
28153808
sparser
"This activity stopped dendritic spine formation via L-type voltage-dependent calcium channel activity and protein synthesis."
29425501
sparser
"Key Words: brain ischemia, nimodipine, 1,4-DHP calcium channel antagonist receptors It is known that binding of 1,4-dihydropyridine (DHP) calcium channel antagonists to voltage dependent calcium channels (VDCC) is dependent on cell membrane polarization and these drugs bind with a much higher affinity to VDCC in depolarized membranes (1,2)."
10755471
sparser
"Perry, D.C., Wei, H., Rosenthal, R.E. and Fiskum, G. (1994) Autoradiographic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral iscbemia/reperfusion."
8877597
sparser
"A membrane pathway for the binding of dihydropyridine calcium channel antagonists to the L-type calcium channel has been proposed by Rhodes and coworkers [23]."
7945438
sparser
"Mutations in the CACNA1A calcium channel subunit gene on chromosome 19 are associated with a wide spectrum of mutation-specific episodic and chronic neurological disorders, including FHM with or without coma."
11409427
sparser
"For example, the light chains of the MT-associated protein 1B (LC1-MAP1B) and MT-associated protein 1A (MAP1A) interact with the presynaptic voltage dependent calcium channel Ca v 2.2 ( xref ; xref )."
27504085
sparser
"Perry, D.C., H, Wei, R.E. Rosenthal and G. Fiskum, 1994, Autoradio- graphic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral ischemia/reperfusion, Brain Res, 657, 65, Shek, J.W.."
8960859
sparser
"As indicated in xref , we also identified SNPs that showed the same direction of effect for schizophrenia and AD+P risk, Notable among these were two intronic SNPs located in CACNA1C , the gene encoding the voltage-dependent L-type calcium channel subunit alpha-1C. Although the genetic mechanism underlying these associations remains an area of active inquiry, xref convergent data suggests that schizophrenia is associated with reduced voltage-dependent calcium channel function. xref – xref How reductions in voltage-dependent calcium channel function may further increase AD+P risk is not known, however, impairments of intracellular Ca 2+ homeostasis are present in AD, and can contribute to synaptic dysfunction and cognitive impairments. xref "
28461698
sparser
"Experiments with recombinant proteins were performed to map synaptic protein interaction sites on the alpha 1A subunit, which forms the pore of the P/Q-type calcium channel."
10212477
sparser
"Epidemiological studies have shown that the use of L-type voltage-dependent calcium channel (L-VDCC) antagonists by patients with cardiovascular conditions is associated with a reduced incidence of AD in [ xref ] and patients treated with the L-VDCC antagonist nimodipine have improved cognitive scores compared to placebo-treated patients [ xref ]."
25888781
sparser
"These data are consistent with the view that aspect of the sleep-altering activity of triazolam involves interaction with voltage-dependent calcium channel activity."
7916912
Calcium_channels binds CACNA1A and LTP. 1 / 1
| 1
sparser
"Last, a voltage-dependent calcium channel-dependent form of LTP in the CA1 could also be reversibly abated by LY294002, raising the possibility that PI3-kinase could be required for the expression of multiple forms of synaptic potentiation."
11978812
Calcium_channels binds CACNA1A and GADD45A. 1 / 1
| 1
sparser
"Focal knockdown of growth arrest and DNA-damage-inducible protein 45β expression attenuated ligation-induced allodynia (n = 7) by reducing the binding of growth arrest and DNA-damage-inducible protein 45β to the voltage-dependent T-type calcium channel 3.2 subunit promoter (n = 6) that decreased expression of and current mediated by the voltage-dependent T-type calcium channel 3.2 subunit (both n = 6)."
28346321
Calcium_channels binds Myosin_complex, CACNA1A, and GTF2B. 1 / 1
| 1
sparser
"Ablation of myosin-IIB in mice is embryonic lethal, and myosin-IIB ( MYH10 ) mutations are thought to be embryonic lethal in humans, as well; however, myosin-IIB function has been associated with the pathogenesis of spinocerebellar ataxia type 6 (SCA6) through associations of myosin-IIB and Cav2.1 calcium channel polyglutamate tracts [ xref ]."
20850431
Calcium_channels binds Voltage_gated_ion_channels, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"Autosomal dominant mutations in the CACNA1A gene, which encodes the voltage-gated P/Q-type calcium channel alpha1 subunit, has also been associated with cerebellar ataxia, vertigo, epilepsy, and schizophrenia (see below) in addition to FHM (Lhatoo et al., xref )."
24312013
Calcium_channels binds CACNA1A, CACNA1B, and CACNA1C. 1 / 1
| 1
sparser
"For instance, association of several voltage-dependent calcium channel genes such as CACNA1C and CACNA1B was reported in large-scale GWAS for BD. xref , xref A pathway analysis of GWAS data suggests enrichment of calcium channel-related pathways among the genes empirically associated with BD. xref Studies of peripheral blood cells have consistently demonstrated altered intracellular calcium signaling in BD. xref , xref Lithium, the first-line therapeutic drug for BD, modulates inositol-mediated pathways xref and thereby regulate calcium ion release from the endoplasmic reticulum. xref When we performed a GO enrichment analysis using DAVID xref , xref by integrating the data of de novo protein-altering mutations in our study, common single-nucleotide polymorphisms associated with BD in a large-scale GWAS xref and rare CNVs implicated in BD xref (total no. of unique input genes=229, see xref for details), ‘calcium signaling pathway (hsa04020)' was the only term significantly enriched after performing correction for multiple testing ( P corrected =6.4 × 10 −3 , Bonferroni correction; note that significant enrichment of ‘calcium signaling pathway (hsa04020)' after correction was not observed when we submitted candidate genes from each study)."
27217147
Calcium_channels binds CACNA1A, CLCN2, TUBB3, and DLL1. 1 / 1
| 1
sparser
"Mutations of gamma-aminobutyric acid receptor alpha1, gamma-aminobutyric acid receptor delta, calcium channel voltage-dependent beta4 subunit and chloride channel 2 gene are associated with juvenile myoclonic epilepsy."
19298753
Calcium_channels binds Myosin_complex, CACNA1A, CC2D2A, and GTF2B. 1 / 1
| 1
sparser
"Ablation of myosin-IIB in mice is embryonic lethal, and myosin-IIB ( MYH10 ) mutations are thought to be embryonic lethal in humans, as well; however, myosin-IIB function has been associated with the pathogenesis of spinocerebellar ataxia type 6 (SCA6) through associations of myosin-IIB and Cav2.1 calcium channel polyglutamate tracts [ xref ]."
20850431
CACNA1A inhibits Calcium_channels.
| 6
CACNA1A inhibits Calcium_channels. 6 / 6
| 6
sparser
"These gain-of-function mutations result in an impaired open-state and voltage-dependent inactivation of the L-type calcium channel, ultimately leading to a markedly prolonged myocardial action potential (delayed ventricular repolarization) ( xref - xref )."
26301350
sparser
"This gain-of-function mutation results in an impaired open-state voltage-dependent inactivation of the L-type calcium channel, ultimately leading to a markedly prolonged myocardial action potential [ xref , xref ]."
21915623
sparser
"This mutation greatly reduces voltage-dependent inactivation of the calcium channel with little effect on calcium-dependent inactivation ( xref ), and thus may potentially cause a pathogenic calcium overload in cardiac and neuronal cells."
22705413
sparser
"In contrast, the cyclin-dependent kinase inhibitor roscovitine, which enhances voltage-dependent inactivation of the L-type calcium channel, was able to decrease the number of tyrosine hydroxylase neurons xref ."
26826498
sparser
"As predicted by the genetic variant, patch clamp analysis revealed reduced L-type calcium channel voltage-dependent inactivation in Timothy syndrome iPSC-CMs."
24632794
sparser
"In all experiments γ-5 had no significant effect on the modulation of voltage-dependent activation and inactivation of the α 1A calcium channel."
10734232
CACNA1A activates Calcium_channels.
| 1 4
CACNA1A activates Calcium_channels. 4 / 4
| 1 4
sparser
"CAP 25 nmol/L shifted the steady-state activation curve of I(Ca-L) to the left and changed half activation potential (V(0.5)) from (-20.76+/-2.0) mV to (-26.71+/-3.0) mV (P<0.05), indicating that low-dose CAP may modify the voltage-dependent activation of calcium channel."
15127137
sparser
"In all experiments γ-5 had no significant effect on the modulation of voltage-dependent activation and inactivation of the α 1A calcium channel."
10734232
sparser
"It was shown 30 years ago that dihydropyridine voltage-dependent calcium channel blockers decreased MR activation by blunting the release of intracellular calcium that activates aldosterone synthesis by adrenal zona glomerulosa cells xref – xref ."
26466326
sparser
"We conclude that 1) the beta subunit increases the number of functional alpha 1 subunits expressed in the plasma membrane of these cells and 2) the voltage-dependent activation of the human cardiac L-type calcium channel involves the movements of at least two nonidentical and functionally distinct gating structures."
8785284
CACNA1A affects FOXH1
| 27
CACNA1A inhibits FOXH1.
| 24
CACNA1A inhibits FOXH1. 24 / 24
| 24
sparser
"T-channels require a smaller depolarization for opening, exhibit relatively fast voltage-dependent inactivation and at resting membrane potential there is a small fraction of channels available for opening to form so called “window” currents ( xref )."
29468189
sparser
"Likewise, intracellular protease application has been shown to produce strong stimulation of VGCCs and a partial loss of fast voltage-dependent inactivation, which has been linked to C-terminal cleavage of a conserved autoinhibitory region in the pore-forming Ca v α 1 subunit ( xref ; xref ; xref ; xref )."
29453293
sparser
"Both channels are characterized by fast voltage-dependent inactivation; the cytoplasmic N-terminus has a positively charged ball that provokes the fast closing of the channel by occluding the pore once it is opened xref ."
28522852
sparser
"Gbeta1 and Gbeta2 strongly mimicked the fast voltage-dependent inhibition of calcium channels produced by many G-protein-coupled receptors."
9801356
sparser
"HERG has fast voltage-dependent inactivation, relatively slow deactivation, and fast recovery from inactivation."
21806931
sparser
"However, the prototypical model for voltage-dependent inactivation remains the “ball-and-chain model,” first designed to account for fast voltage-dependent inactivation in Na + channels ( Armstrong and Bezanilla, 1977 )."
9746514
sparser
"The well documented fast voltage-dependent inactivation of the hERG K + current may represent the I P , but I C has not been described possibly because it is prevented by external K + ions."
16769794
sparser
"We have demonstrated that the hERG channel displayed its unique fast voltage-dependent inactivation and recovery from inactivation when a K + free, Na + rich intracellular solution was used ( xref and xref )."
16769794
sparser
"One confounding issue is a potential interplay between calcium- and voltage-dependent properties, such as the consequences of a Ca 2+ –CaM-binding site identified in the III–IV linker of Na v 1.5 sodium channels, which is also the region responsible for the fast voltage-dependent inactivation within sodium channels ( xref , xref , xref )."
28972185
sparser
"In addition to the fast voltage-dependent inhibition by Mg 2+ , intracellular Mg 2+ ions have been shown to induce a further, slow inactivation of TRPV5/6 channels [ xref , xref ], which could be reversed by increasing PIP 2 levels in the plasma membrane [ xref ]."
25106481
sparser
"The mutant FHF1 proteins had a strong gain-of-function phenotype in transfected Neuro2A cells, enhancing the depolarizing shifts in Nav1.6 voltage-dependent fast inactivation, predicting increased neuronal excitability."
27164707
sparser
"These channels are activated at negative membrane potentials and show a fast voltage-dependent inactivation with respect to other VSCCs."
28290248
sparser
"To study isradipine effects on I(Ba) decay without contamination by intrinsic inactivation we expressed a mutant (V1504A) lacking fast voltage-dependent inactivation."
11487504
sparser
"The fast voltage-dependent inactivation limits outward current through the channel at positive voltages and thus helps maintain the action potential plateau phase that controls contraction and prevents premature excitation."
16769794
sparser
"Our data further showed that the hERG Na + current displayed an inactivation that is different from the well documented fast voltage-dependent hERG inactivation."
16769794
sparser
"This mutation is known to disrupt fast voltage-dependent hERG inactivation but retains high K + selectivity ( xref ; xref )."
16769794
sparser
"In summary, data in xref and xref indicate that the hERG channel displayed its unique fast voltage-dependent inactivation and recovery from inactivation when a K + -free, 135 mM Na + pipette solution was used."
16769794
sparser
"T-type VDCCs reach their peak conductance at -30 mV and undergo fast voltage-dependent inactivation, which is half-maximal at -65 mV. xref Differences between the roles VDCCs play in mouse and human β cells are illustrated in xref and xref ."
28662366
sparser
"Our data suggest that the isradipine-induced acceleration of the Ca(v)1.2 current decay reflects enhanced fast voltage-dependent inactivation and not open channel block."
11487504
sparser
"The kinetic hallmark of T-type channels is slow activation and fast voltage-dependent inactivation."
20951705
sparser
"The constructed model could closely reproduce the experimental Ba2+ and Ca2+ current results under basal condition where no beta-stimulation was added after a slight reduction of the development of fast voltage-dependent inactivation with depolarization."
17822746
sparser
"Furthermore, AA regulates the inactivation process in other Kv channels, introducing a fast voltage-dependent inactivation in non-inactivating Kv channels."
22973228
sparser
"As stated above, it has been described that AA regulates the inactivation process in other potassium channels, introducing a fast voltage-dependent inactivation into non-inactivating Kv channels (Oliver et al., xref )."
22973228
sparser
"The mutations also disabled FHF modulation of voltage-dependent fast inactivation of sodium channels in neuronal cells."
19406745
CACNA1A activates FOXH1.
| 2
CACNA1A activates FOXH1. 2 / 2
| 2
sparser
"The I component is characterized by a fast voltage-dependent activation and a voltage-independent (ms) time constant of inactivation."
23284723
sparser
"Canonical models of Kv channel activation associate sudden changes in membrane potential with rapid movements of the voltage sensors, which are ultimately responsible for fast voltage-dependent activation."
18299396
CACNA1A binds FOXH1.
| 1
KCN binds CACNA1A, FOXH1, and IK. 1 / 1
| 1
sparser
"In Drosophila neurons the fast component of I K has been associated with the voltage-dependent potassium channel gene Shal ( Shaker cognate I ) ( xref ) and the voltage-dependent and calcium-activated potassium channel gene slowpoke ( slo ) ( xref )."
18305244
CACNA1A affects ion channel
| 20 1
CACNA1A binds ion channel.
| 8
CACNA1A binds ion channel. 8 / 8
| 8
sparser
"It was reported that pllp could form voltage-dependent and K(+)-selective ion channels in the membrane, or act as entry receptor for a kind endogenous retrovirous xref ."
23285140
sparser
"Here we introduce a new technique to monitor voltage-dependent charge displacement associated with Sh B-IR K + ion channels using RF electric fields during TEVC."
21387000
sparser
"The addition of a crude preparation of purified plasmolipin to lipid bilayers was able to induce the formation of voltage-dependent and potassium-selective ion channels in vitro ( Tosteson and Sapirstein, 1981 ), but the exact functional role of this intriguing protein in neural and non-neural tissues remains to be clarified."
9168137
sparser
"The voltage-dependent formation of alamethicin ion channels has been described by different models [ 9 ]."
9733952
sparser
"Some of the interactions that are relevant from this study’s point of view are as follows: (1) low-density lipoprotein receptor-related protein (LRP) is an important receptor for apolipoprotein E in the brain and is responsible for apolipoprotein E trafficking in the neuronal cells. xref LRP is co-expressed with Apo E since it is the primary receptor for lipidated form of Apo E; (2) voltage-dependent ion channel interaction affects intra-neuronal Ca2+ concentration, thereby affecting dopamine release to into the synapse in Parkinson’s disease; (3) α-synuclein is involved in aggregation to form inclusion bodies called as Lewy body and is a pathological hall mark of Parkinson’s disease. xref xref – xref There is association between α-synuclein-related neurotoxicity and increased apolipoprotein E levels in Parkinson’s disease. xref "
30327579
sparser
"In contrast to the single inhibition pathway induced by direct voltage-dependent interactions between Gβγ subunits and ion channels, there appear to be multiple pathways that induce voltage-independent inhibition of neuronal Ca 2+ current via a number of second messengers and protein kinases [ xref , xref , xref ]."
26633526
sparser
"The formation of hippocampal synapses is associated with increased expression and activation of ligand-gated ion channels and voltage-dependent Ca 2+ channels, which increases the energy demand required to operate the ion-motive ATPases that restore the membrane potential xref ."
23212379
sparser
"It is therefore of interest to determine whether other members of Type-II positive allosteric modulator family facilitate similar voltage-dependent interactions between α7 nicotinic receptor-mediated ion channels and charged compounds including those (i.e., choline and bicuculline) tested in this study."
24036349
CACNA1A inhibits ion channel.
| 7
CACNA1A inhibits ion channel. 7 / 7
| 7
sparser
"It is concluded that electrical restitution in rat ventricular muscle is relatively little affected by recovery from voltage-dependent inactivation of ion channels, it is rather governed by transient changes in cytosolic Ca concentration possible via Ca-dependent inactivation of the L-type Ca current and activation of the Na/Ca exchange current."
8899061
sparser
"Voltage-dependent inhibition of ligand-gated ion channels suggests binding of the inhibitory drug to a site within the channel or at the mouth of the channel."
11044725
sparser
"However, the regulation of glucagon secretion is more complicated since it has been shown that exocytosis can as well be triggered by membrane depolarization via a voltage-dependent inactivation of ion channels involved in action potential generation ( xref )."
20978093
sparser
"Structure/function studies from this laboratory have demonstrated that pH gating follows a particle-receptor mechanism, similar to the "ball-and-chain" model of voltage-dependent inactivation of ion channels."
9670915
sparser
"This behavior is notably different from the canonical voltage-dependent inactivation of ion channels, where channels enter an absorbing non-conductive inactive state [ xref ]."
25966688
sparser
"Thus it is likely that other mechanisms, in addition to disrupted ionic gradients and voltage-dependent inactivation of ion channels, are involved in the prolonged suppression of synaptic activity."
22864185
sparser
"We propose that glucose-induced closure of the K(ATP)-channels, via membrane depolarization, culminates in reduced electrical activity and glucagon secretion by voltage-dependent inactivation of the ion channels involved in action potential firing."
21824262
CACNA1A activates ion channel.
| 5 1
CACNA1A activates ion channel. 6 / 6
| 5 1
sparser
"Voltage-dependent activation and deactivation of ion channels in the Shaker superfamily were thought to be mainly determined by the transmembrane channel domains."
9635749
sparser
"The simulations of guanidinium ion permeation also provide new insights into the mechanism of voltage-dependent activation of voltage-gated ion channels."
28074656
reach
"Full-length CACNA1A mRNA produces the alpha1A ion channel subunit."
25108806
sparser
"The Boltzan sigmoid equation is the one that describes voltage-dependent activation of ion channels, where conductance ( Y ) is described as a function of the membrane potential ( X )."
10529010
sparser
"In a recent study ( xref ), we have shown that the net free energy associated with voltage-dependent activation of an ion channel can be estimated by extracting the median voltage of activation from the Q-V curve using the relation:"
23250866
sparser
"Our simulations provide insights into the Shaker VSD permeation pathway, the protein-ion interactions that control permeation kinetics, and the mechanism of voltage-dependent activation of voltage-gated ion channels."
28074656
Sodium atom affects CACNA1A
| 20
Sodium atom inhibits CACNA1A.
| 14
Sodium atom inhibits CACNA1A. 14 / 14
| 14
sparser
"But at a fixed and elevated Na, some of the linearity of K Na activation over then range of -80 to -20 mV will arise from a combination of increased activation by voltage and also voltage-dependent inhibition by intracellular Na."
26559620
sparser
"Pulmonary veins with dormant conduction show less radiofrequency-induced depolarization than non-dormant veins do, allowing for adenosine-induced hyperpolarization to restore excitability by removing voltage-dependent sodium current (I Na ) inactivation at less negative membrane potentials."
28765753
sparser
"Deficits in sodium channel may contribute to these phenotypes since hippocampal neurons from BACE1-null mice display a positive shift in voltage-dependent sodium current inactivation as well as an increase in sodium current densities as compared to control wild-types [ xref , xref ]."
20817076
sparser
"To explore the effects of IL-6 on other aspects of voltage-gated Na + channels, we analyzed and compared voltage-dependent Na + channel activation and inactivation at different doses and various time points."
26170823
sparser
"Thus, the specific abolition of voltage-dependent Na + current inactivation by intracellular treatment with proteolytic enzymes (Armstrong et al., xref ) subsequently led to the proposal of a “ball-and-chain” mechanism as the determinant of this inactivation process (Armstrong and Bezanilla, xref )."
22470342
sparser
"The “switch-off” frequency was not due to voltage-dependent Na + channel inactivation because simulations were performed with HH parameters, limiting the inactivation of Na + channels (see the simulation methods for Na + channels)."
26912194
sparser
"MFN2-mutant motor neurons had an increased density of sodium currents in their membrane, and their voltage-dependent sodium channels demonstrated impaired inactivation after a use-dependent paradigm, compared to controls."
25448007
sparser
"Resting cells would generate suprathreshold GABA A receptor-mediated depolarizing postsynaptic potentials, whereas spontaneously active cells would be driven into a refractory state due to voltage-dependent sodium channels inactivation ( xref )."
30071194
sparser
"The finding that all α-cells (and some β-cells) exhibit biphasic voltage-dependent Na + current inactivation suggests that Na + channel subunits with widely different inactivation properties are coexpressed in individual cells."
25172946
sparser
"The alpha2* isoform was, however, more sensitive to voltage-dependent inhibition by extracellular Na(+), indicating a higher affinity of the extracellular Na(+) site in this isoform."
11897839
sparser
"Cells where the inactivating, slowly deactivating current phenotype prevails feature a robust afterhyperpolarization that relieves voltage-dependent Na + channel inactivation and thus, promotes repetitive AP firing ( xref ; xref ; xref ; xref )."
22584144
sparser
"We have demonstrated that the “switch-off” frequency is not due to voltage-dependent Na + channel inactivation (see above)."
26912194
sparser
"Membrane hyperpolarization removes voltage-dependent Na + current inactivation, increases the source Na + current, and permits faster and more stable rotor activity."
19968926
sparser
"The repetitive firing observed in skeletal muscle fibres in patients with paramyotonia congenita arises from an incomplete voltage-dependent Na + channel inactivation thus leaving some channels in a conductive state [ xref ]."
28265756
Sodium atom activates CACNA1A.
| 6
Sodium atom activates CACNA1A. 6 / 6
| 6
sparser
"This is not always the case, however, as 1,8-cineole, a terpenoid, was demonstrated to cause depolarization of the resting membrane and to block excitability, mainly indirectly, via the effect of depolarization voltage-dependent Na + current activation ( xref )."
24345915
sparser
"This presumably reflects weaker and more gradual voltage-dependent Na + (and Ca 2+ ) channel activation in the spontaneously firing cells given their somewhat more positive resting potentials."
25267913
sparser
"Hypocalcemia increases neuronal membrane excitability by reducing the threshold of voltage-dependent Na + channel activation [ xref ] and by directly interacting with channel gating machinery [ xref ]."
22018206
sparser
"This conditioning step would elicit a voltage-dependent Na + current activation as similarly achieved in the previous protocols that had been used to study Na + channel activation properties."
29197478
sparser
"To explore the effects of IL-6 on other aspects of voltage-gated Na + channels, we analyzed and compared voltage-dependent Na + channel activation and inactivation at different doses and various time points."
26170823
sparser
"A perturbative expansion of the non-dimensional membrane potential (Phi) is used to obtain time-dependent analytical solutions, involving a voltage-dependent Na(+) activation (micro) and a state-dependent inactivation (eta) gating variables."
15366097
G_protein affects CACNA1A
| 19
G_protein inhibits CACNA1A.
| 13
G_protein inhibits CACNA1A. 13 / 13
| 13
sparser
"In tsA-201 cells, expression of N-type channels with human ORL1 resulted in a voltage-dependent G-protein inhibition of the channel that occurred in the absence of nociceptin, the ORL1 receptor agonist."
14730309
sparser
"Reconstitution of Voltage-dependent G-Protein Inhibition of N- and P/Q-type Calcium Channels."
10653895
sparser
"In 5 out of 10 nociceptin-responsive cells tested, I Ba inhibited by nociceptin was facilitated by the prepulse and exhibited slowed activation kinetics, another hallmark of voltage-dependent G protein inhibition ( Fig. 5 A)."
9687009
sparser
"From our data it is apparent that either alpha 1A or alpha 1B Ca2+ channels expressed alone are sufficient for voltage-dependent G protein inhibition. alpha 1C Ca2+ channels expressed alone do not exhibit the G protein inhibition seen in alpha 1A and alpha 1B channels."
7664882
sparser
"G protein (Gβγ)-mediated voltage-dependent inhibition of N- and P/Q-type Ca 2+ channels contributes to presynaptic inhibition and short-term synaptic plasticity."
19109500
sparser
"In this manuscript we have narrowly focused on the contribution of individual amino acids in the Ca v 2.2 I-II linker region to voltage dependent G protein inhibition of the channel."
20181083
sparser
"Direct interaction with the β subunit of the heterotrimeric G protein complex causes voltage-dependent inhibition of N-type calcium channels."
20181083
sparser
"A leading mechanistic framework for such modulation is the “willing-reluctant” model of voltage-dependent G-protein inhibition ( xref ; xref )."
12771191
sparser
"In COS-7 cells, G protein inhibition of N-type Ca 2+ channels was markedly enhanced by coexpressed Ca v βs [ xref ]; in tsA-201 cells, a point mutation in the AID of Ca v 2.2 (W391A) that disrupted Ca v β binding abolished voltage-dependent G protein inhibition [ xref ]."
22981275
sparser
"To articulate the specific scope of the experiments and results, we first review the “willing-reluctant” model of voltage-dependent G-protein inhibition of neuronal calcium channels ( xref ; xref ), a leading mechanistic framework for rationalizing the key functional features of this form of modulation."
10653895
sparser
"Ifproven to be correct, voltage-dependent G-protein inhibition would represent one ofthe rare instances ofion channel modulation bychanges inpermeation as well as in gating (Chen and Huang, 1992)."
8913590
sparser
"These include reports that the α 1B N-terminus acts as a gated module that enables voltage-dependent G-protein βγ subunit inhibition of Ca V 2.2 channels; xref a role for α 1C N-terminus in protein kinase C modulation of Ca V 1.2 channels; xref that the N-termini of Ca V 1.2 and Ca V 1.3 channels contains a Ca 2+ -CaM binding site (termed NSCaTE for N-terminal spatial Ca 2+ transforming element) that controls local vs. global spatial Ca 2+ selectivity for CaM regulation of Ca V channels; xref and that deleting segments of α 1C N-terminus increases I Ca,L by enhancing channel P o . xref "
27115600
sparser
"These alterations in kinetics may help explain the apparent reduced voltage-dependent inhibition by G proteins of the Ca V 2.1 mutant channels."
22549042
G_protein binds CACNA1A.
| 6
G_protein binds CACNA1A. 6 / 6
| 6
sparser
"The inhibition of Ca 2+ currents through P2Y12 receptors included a slowing of activation kinetics that is characteristic of the voltage-dependent interaction between G protein βγ subunits and channel proteins and was attenuated by pertussis toxin, but not by a phospholipase C inhibitor."
27172914
sparser
"Receptor activation subjects presynaptic N- and P/Q-type calcium channels to a rapid, membrane-delimited inhibition-mediated by direct, voltage-dependent interactions between G protein betagamma subunits and the channels-and to a slower, voltage-independent modulation involving soluble second messenger molecules."
17132857
sparser
"De Waard M, Liu H, Walker D, Scott VES, Gurnett CA and Campbell KP, Direct binding of G protein ß-y complex to voltage dependent calcium channels."
9278091
sparser
"It can be relieved by applying large positive pulses ( xref ; xref ; xref ), and is understood as direct voltage-dependent binding of G-protein βγ subunits to N-type (Ca V 2.2) and P/Q-type (Ca V 2.1) Ca 2+ channels ( xref ; xref ; xref )."
20670831
sparser
"None of the kinetic components depended on the way the channel was activated, or reflected a voltage-dependent interaction with a G protein; thus, the three kinetic components were interpreted as representing intrinsic gating and as reflecting three distinct closed or blocked states of the channel [39] ."
9429760
sparser
"Direct interaction with the β subunit of the heterotrimeric G protein complex causes voltage-dependent inhibition of N-type calcium channels."
20181083
CACNA1A affects EA2
| 18
CACNA1A activates EA2.
| 15
CACNA1A activates EA2. 12 / 12
| 12
reach
"CACNA1A and CACNB4 mutations lead to EA2 (MIM 108500) and EA5 (MIM 613855), respectively [XREF_BIBR, XREF_BIBR]."
26715324
reach
"EA2 is caused by mutations in CACNA1A, a gene coding for the neuronal voltage gated calcium channel Cav1.1."
21492892
reach
"Molecular genetic tests for episodic ataxia type 2 (EA2) usually target only the specific calcium channel gene (CACNA1A) that is known to cause EA2."
30314295
reach
"EA2 is caused by mutations in the CACNA1A gene, mapped to chromosome 19p13 [XREF_BIBR], which encodes the alpha-subunit of the P/Q-type voltage gated calcium channel, Ca v 2.1 [XREF_BIBR, XREF_BIBR]."
22379397
reach
"The authors investigated whether large scale genetic rearrangements in CACNA1A can cause EA2 and FHM1."
19586927
reach
"Mutations of KCNA1 and CACNA1A cause episodic ataxia 1 (EA1 : MIM # 160120) and episodic ataxia 2 (EA2 : MIM # 108500), respectively."
12736095
reach
"EA2 is caused by a wide range of mutations in CACNA1A, localized on chromosome 19p, which encodes the pore forming alpha 1A subunit of the Ca V 2.1 Ca 2+ channel (Ophoff etal."
27066515
reach
"To date, eight types of EA have been described; the dominant forms are EA1 (OMIM, 160120) and EA2 (OMIM, 108500), caused by mutations in KCNA1 (OMIM, 176260) and CACNA1A (OMIM, 601011), respectively."
30314295
reach
"Dominant mutations in CACNA1A underlie at least three allelic diseases : EA2, familial hemiplegic migraine type 1 and spinocerebellar ataxia type 6."
22379397
reach
"EA2 is caused by mutations in CACNA1A."
19822774
reach
"Mutations in a potassium channel gene (KCNA1) located on chromosome 12p13 underlie EA1, and in a voltage dependent calcium channel gene (CACNA1A) located on chromosome 19p13 can lead to EA2."
24665320
reach
"We describe a family with episodic ataxia, clinically indistinguishable from EA2, that was not caused by CACNA1A gene mutation."
12525875
Mutated CACNA1A activates EA2. 3 / 3
| 3
reach
"CACNA1A mutations underlie three allelic disorders : familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6."
30063100
reach
"EA2 is caused by CACNA1A mutations that mostly result in truncation of the encoded Ca V 2.1 alpha 1A channel subunit, while missense mutations have also been reported [XREF_BIBR]."
26716990
reach
"Different mutations of the CACNA1A genes, which encode the immunogenic alpha-1A VGCC subunit (Ca v 2.1), can produce the autosomal dominant SCA type 6, episodic ataxia type 2 (EA2) or familial hemiplegic migraine 1 (FHM1)."
26377184
CACNA1A inhibits EA2.
| 3
CACNA1A inhibits EA2. 3 / 3
| 3
reach
"In contrast to FHM1, EA2 is caused by loss-of-function mutations in CACNA1A."
24592212
reach
"EA2 is caused most often by loss of function mutations of the calcium channel gene CACNA1A."
27066515
reach
"Deletion of several exons of CACNA1A may cause EA2 and should be assessed in patients having EA2 without a CACNA1A point mutation."
18541804
CACNA1A affects potassium(1+)
| 16
CACNA1A inhibits potassium(1+).
| 10
CACNA1A inhibits potassium(1+). 10 / 10
| 10
sparser
"K+ currents showed voltage-dependent inactivation which was half-maximal at -25 mV."
1822525
sparser
"We propose that the eag domain may destabilize or mask an inherent voltage-dependent inactivation of rEag1 K+ channels."
25333352
sparser
"In the absence of sodium in the bathing medium, the overshoot reverses polarity near--75 mV and is associated with an increase in resistance, suggesting that it is mediated by a voltage-dependent inactivation of potassium."
755286
sparser
"The Kv7 family of voltage-dependent non-inactivating potassium channels is composed of five members, of which four are expressed in the CNS."
31238068
sparser
"Mechanical modulation of a voltage-dependent non-inactivating K+ current in cultured bullfrog sympathetic neurones."
8437884
sparser
"The biophysical origin of such effect is believed to be the differential kinetics of the voltage-dependent activation and inactivation of sodium and potassium channels on the neuron membrane (for further details, see xref )."
21408148
sparser
"The outward potassium current showed voltage-dependent activation and inactivation, similar to that seen for A-currents."
1422573
sparser
"NKA depressed a voltage-dependent non-inactivating K+ current, the M-current (IM), at potentials more positive than -55mV."
7474855
sparser
"These experiments revealed that Kv1.4 is expressed only in transfected cells where it elicits the typical voltage-dependent, rapidly inactivating K+ current."
9560284
sparser
"SP (3 nM to 1 microM) suppressed the voltage-dependent non-inactivating K+ current, the M-current (IM) by reducing the maximum M-conductance."
7516511
CACNA1A activates potassium(1+).
| 6
CACNA1A activates potassium(1+). 6 / 6
| 6
sparser
"The parameters m , n and h are dynamic variables that describe the voltage-dependent activation of sodium and potassium channels, and the sodium channel deactivation after spike initiation, respectively."
30158188
sparser
"The response of mTRPA1 to menthol is reminiscent of voltage dependent activation of human ether-a-go-go-related gene (hERG) potassium channels: strong depolarizations cause hERG to transit through the open state to an inactivated state and, upon repolarization, return to the open state before closing ( xref ; xref )."
18815250
sparser
"Pretreatment of the rings with TEA (10-3 M, 15 rain) and 4-AP (10-3 M, 15 rain), a blocker of voltage-dependent or Ca2+- activated K+ channels, partly inhibited the relaxation (Fig. 3)."
8041228
sparser
"The outward potassium current showed voltage-dependent activation and inactivation, similar to that seen for A-currents."
1422573
sparser
"The biophysical origin of such effect is believed to be the differential kinetics of the voltage-dependent activation and inactivation of sodium and potassium channels on the neuron membrane (for further details, see xref )."
21408148
sparser
"In 2002, he held the position of lecturer in Biochemistry at the University of Bologna (Italy), and in 2003, he moved to UC Berkeley as a postdoctoral scholar, where he studied the mechanism of voltage-dependent activation of voltage-gated potassium and proton channels in the laboratory of Ehud Y. Isacoff."
29367199
CACNA1A affects FHM1
| 16
CACNA1A activates FHM1. 14 / 14
| 14
reach
"In addition, some CACNA1A gene point mutations causing FHM1 may be associated with impairment of the cerebellar system."
26675662
reach
"FHM1 is induced by mutations in CACNA1A at chromosome 19p13, which encodes the Cav2.1 (P/Q-type)."
27313535
reach
"Episodic ataxia, type 2 (EA2) and SCA6 are allelic disorders to FHM1 caused by mutations in the CACNA1A gene on chromosome 19p13 encoding the neuronal P/Q-type voltage gated calcium channel [XREF_BIBR, XREF_BIBR]."
25969684
reach
"Familial hemiplegic migraine type 1 (FHM1), a severe migraine with aura variant, is caused by mutations in the CACNA1A gene."
19847904
reach
"FHM1, FHM2 and FHM3 are caused by mutations in the ion-channel genes CACNA1A, ATP1A2 and SCN1A, respectively [XREF_BIBR - XREF_BIBR]."
18846413
reach
"In particular, FHM1 (OMIM 141500) is caused by mutations in the CACNA1A calcium channel subunit (see below), FHM2 is caused by mutations in the alpha2 subunit of the Na, K-ATPase pump (ATP1A2; OMIM 602481), and FHM3 has been more recently associated to mutations in Na v 1.1 channels."
26236192
reach
"FHM1, which accounts for approximately 50% of FHM cases, is caused by mutations in the CACNA1A gene, which encodes the alpha-1 subunit of a high-voltage-gated P/Q type calcium channel (Cav2.1)."
22969264
reach
"We present a case with FHM1 caused by an R583Q mutation in the CACNA1A gene with cerebellar ataxia, and also parkinsonism, a feature which has not previously been reported in association with FHM1."
25969684
reach
"FHM1 is caused by mutations in the CACNA1A gene, which encodes the alpha1A subunit of Cav2.1 channels; the R192Q mutation in CACNA1A causes a mild form of FHM1, whereas the S218L mutation causes a severe, often lethal phenotype."
19104150
reach
"FHM is a genetically heterogeneous disease, in which mutations can occur in the ion transportation genes CACNA1A, ATP1A2, and SCN1A, promoting the different types of familial migraines, FHM1, FHM2 and FHM3."
27313535
reach
"The authors investigated whether large scale genetic rearrangements in CACNA1A can cause EA2 and FHM1."
19586927
reach
"We report a 63-year-old woman with FHM1 caused by an R583Q mutation in the CACNA1A gene, clinically presenting with migraine and permanent cerebellar ataxia."
25969684
reach
"FHM1 is caused by mutations in CACNA1A gene that codes for the pore forming alpha 1A subunit of neuronal voltage gated Ca V 2.1 channels [XREF_BIBR]."
27032388
reach
"Genetically and clinically heterogeneous, FHM1 is caused by mutations in CACNA1A and FHM2 by mutations in ATP1A2."
17435187
Mutated CACNA1A activates FHM1. 2 / 2
| 2
reach
"FHM is classified into 3 types : FHM1, which is caused by CACNA1A mutations on chromosome 19p13, FHM2, caused by ATP1A2 mutations on chromosome 1q21-23, and FHM3, caused by SCN1A mutations on chromosome 2q24 [XREF_BIBR, XREF_BIBR]."
25969684
reach
"While some gain-of-function CACNA1A mutations cause only FHM1, others can lead to additional maladies, such as epileptic attacks."
24592212
FOXH1 affects CACNA1A
| 13
FOXH1 inhibits CACNA1A.
| 10
FOXH1 inhibits CACNA1A. 10 / 10
| 10
sparser
"In contrast, a pronounced hyperpolarizing shift in voltage-dependent fast inactivation was observed for 30 μ M ( R )- 7 (21.4 mV in V 1/2 ) compared with a more modest change for 30 μ M ( R )- 11 (8.0 mV in V 1/2 )."
21765969
sparser
"Yet, functionally, fhf is thought to modulate only voltage-dependent fast inactivation ( xref ; xref ; xref ), with changes in Ca 2+ -regulation unknown."
30198845
sparser
"The S5-P linker remains the most likely subdomain of the channel to confer voltage-dependent fast inactivation."
21376840
sparser
"As predicted from its location, L1563V in the neonatal isoform resulted in a depolarized shift in voltage-dependent fast inactivation, a reduced rate of entry into inactivation as well as faster recovery from inactivation."
17467289
sparser
"In fact, modeling results showed that I NaT present a voltage dependent fast inactivation process that is the main contributor to the action potential repolarization and hence of is waveform, determining its frequency content of the spikes and its ability to pass through electrical contacts between these cells."
| PMC
sparser
"I G185R rectified more steeply with voltage than I DMT1 , probably due to pronounced time- and voltage-dependent fast inactivation ( xref C; see xref for comparison)."
15024413
sparser
"FGF12 encodes a cytosolic protein that interacts with neuronal sodium channels and increases their voltage-dependent fast inactivation. xref Here, we performed WES-trio analysis and identified the same de novo missense mutation in 2 patients with severe neonatal-onset epilepsy and variable clinical outcomes."
27872899
sparser
"Compared to wild-type Cx43 (Cx43WT), Cx43(∗)NT37 junctions exhibited several functional alterations: extreme resistance to halothane- and acidification-induced uncoupling, absence of voltage-dependent fast inactivation, longer channel open times, larger unitary channel conductances, low junctional dye permeability/permselectivity, and an overall cation selectivity more typical of Cx37WT than Cx43WT junctions."
26745416
sparser
"Depolarizing voltage clamp steps result in currents that appear to inwardly rectify due to voltage-dependent fast inactivation ( Smith et al., 1996; Spector et al., 1996; Schönherr and Heinemann, 1996 )."
10545354
sparser
"In addition to slowing voltage-dependent activation, modulation by G-proteins has also been shown to decrease voltage-dependent fast inactivation ( xref )."
10694257
FOXH1 activates CACNA1A.
| 2
FOXH1 activates CACNA1A. 2 / 2
| 2
sparser
"Using MmKv1, a potassium channel identified from the genome of the scorpion Mesobuthus martensii, channel kinetic experiments showed that MmKv1 was a classical voltage-gated potassium channel with a voltage-dependent fast activation and slow inactivation."
26951716
sparser
"Despite the lack of a canonical voltage sensor in either CALHM1 or CALHM3, integration of CALHM3 into a CALHM1 channel confers to it voltage-dependent fast activation that is similar to that of traditional voltage-gated K + channels (τ ∼10 ms) ( xref ; xref )."
29681531
FOXH1 binds CACNA1A.
| 1
KCN binds CACNA1A, FOXH1, and IK. 1 / 1
| 1
sparser
"In Drosophila neurons the fast component of I K has been associated with the voltage-dependent potassium channel gene Shal ( Shaker cognate I ) ( xref ) and the voltage-dependent and calcium-activated potassium channel gene slowpoke ( slo ) ( xref )."
18305244
CACNA1A affects IK
| 13
CACNA1A activates IK.
| 10
CACNA1A activates IK. 10 / 10
| 10
sparser
"In addition, ischemic conditions produced calcineurin-dependent dephosphorylation and unclustering of Kv2.1, hyperpolarizing shifts in voltage-dependent activation of I K , and reduced spontaneous calcium transients ( xref )."
18753382
sparser
"In agreement with previous studies using exogenously applied glutamate, we observed that bath application of NMDA potently and rapidly unclustered and dephosphorylated Kv2.1 channels and produced a hyperpolarizing shift in the voltage-dependent activation of neuronal I K . Previous studies have shown that hyperactivity associated with seizures or KCl-induced membrane depolarization causes dephosphorylation and unclustering of Kv2.1 channels ( xref )."
18753382
sparser
"As expected, bath application of NMDA to hippocampal cultures reduced the size of Kv2.1 clusters and produced a hyperpolarizing shift in the voltage-dependent activation of I K that was associated with dephosphorylated Kv2.1 channels."
19185209
sparser
"Bath application of NMDA potently unclustered and dephosphorylated Kv2.1 and produced a hyperpolarizing shift in voltage-dependent activation of I K . In contrast, driving synaptic activity in Mg 2+ -free media to hyperactivate synaptic NMDA receptors had no effect on Kv2.1 channels, and moderate pentylenetetrazole-induced seizure activity in adult mice did not dephosphorylate hippocampal Kv2.1 channels."
18753382
sparser
"In the present study, we show that in hippocampus, ethanol prevents the NMDA-induced hyperpolarizing shift in the voltage-dependent activation of neuronal I K and reduces the unclustering and dephosphorylation of Kv2.1 channels."
19185209
sparser
"Glutamate-stimulation of hippocampal neurons has diverse effects on voltage-dependent activation and inactivation of I K via Ca 2+ /calcineurin-dependent intracellular signaling."
19276663
sparser
"Indeed, we found that the cell-permeable Zn 2+ chelator TPEN significantly attenuated the hyperpolarizing shift in the voltage-dependent activation of I K to the same extent as calcineurin inhibition."
20092568
sparser
"A submaximal concentration of Compound II (50 nM) had a significant effect on the time and voltage dependent activation of iK and caused a positive shift of the iK activation curve."
9550297
sparser
"Hyperpolarizing shifts in the voltage-dependent activation of neuronal I K are associated with a dephosphorylation of the Kv2.1 channel ( xref , xref )."
20092568
sparser
"The voltage-dependent activation of the ATP-induced IK during 500 ms depolarizing test pulses could be described by a Boltzmann equation with a half-activation voltage (V1/2) of 11.5 mV and slope factor (k) of 12.0 mV, which were close to those of IKs (V1/2 of 12.1 mV and k of 12.3 mV), determined as an E-4031-resistant IK, under the same isochronal (500 ms) activation conditions."
9288673
CACNA1A binds IK.
| 2
CACNA1A binds IK. 1 / 1
| 1
sparser
"These findings suggest that MS-551 produces frequency-dependent class III action, presumably due to the voltage-dependent binding and unbinding to the IK channels."
8759253
KCN binds CACNA1A, FOXH1, and IK. 1 / 1
| 1
sparser
"In Drosophila neurons the fast component of I K has been associated with the voltage-dependent potassium channel gene Shal ( Shaker cognate I ) ( xref ) and the voltage-dependent and calcium-activated potassium channel gene slowpoke ( slo ) ( xref )."
18305244
CACNA1A inhibits IK.
| 1
CACNA1A inhibits IK. 1 / 1
| 1
sparser
"Glutamate-stimulation of hippocampal neurons has diverse effects on voltage-dependent activation and inactivation of I K via Ca 2+ /calcineurin-dependent intracellular signaling."
19276663
CACNA1A affects translation
| 12
CACNA1A activates translation. 12 / 12
| 12
reach
"miR-3191-5p inhibits the CACNA1A IRES driven translation of alpha1ACT while sparing alpha1A and CACNA1A mRNA expression."
27412786
reach
"These results suggest that miR-3191-5p bound to Ago4 directly interacts with the CACNA1A IRES and selectively inhibits the CACNA1A IRES driven alpha1ACT translation."
27412786
reach
"We also found that knockdown of eIF4GII had a greater effect on the down-regulation of CACNA1A IRES driven alpha1ACT translation than did knockdown of eIF4AII (XREF_FIG)."
27412786
reach
"Considering that an ~ 50% decrease in the number of Purkinje cells is sufficient to cause ataxia and motor deficits in our mouse model, miRNA mediated alpha1ACT SCA6 silencing by blockade of CACNA1A IRES driven translation in greater than half of Purkinje cells would have great potential benefit in presymptomatic or symptomatic SCA6 patients."
27412786
reach
"To examine the therapeutic effects of miR-3191-5p-mediated reduction of CACNA1A IRES driven alpha1ACT SCA6 translation on the disease phenotype of SCA6 mice, we constructed an AAV9 vector that allowed for the simultaneous expression of GFP and either miR-3191-5p (AAV9-miR-3191-5p) or a nonspecific mock miRNA (AAV9-miR-mock) (XREF_SUPPLEMENTARY)."
27412786
reach
"Although AAV9 mediated intervention with miR-3191-5p did not regulate all of the predicted mRNA targets in our mouse model, we showed that miR-3191-5p has a selective silencing effect on the CACNA1A IRES driven translation of alpha1ACT SCA6 in mice."
27412786
reach
"Because both eukaryotic initiation factors (eIFs) eIF4A and eIF4G have been previously shown to be involved in IRES dependent translation in several types of viral IRESs, we examined the effects of these on CACNA1A IRES driven alpha1ACT translation."
27412786
reach
"To examine the effects of these miRNAs on CACNA1A IRES driven translation, we cotransfected these miRNAs with either a bicistronic reporter vector bearing CACNA1A IRES or a control vector into human embryonic kidney (HEK) 293 cells (XREF_FIG)."
27412786
reach
"These results suggest that miR-3191-5p interacts with CACNA1A IRES only through its predicted binding site and inhibits the CACNA1A IRES driven translation of alpha1ACT while sparing alpha1A expression and CACNA1A mRNA expression."
27412786
reach
"Identification of eIF4AII, which may provide helicase activity, and eIF4GII, which may serve as a scaffold, in the mechanism of CACNA1A IRES mediated translation supports recent findings that show the effect of eIFs on cellular IRESs in human disease."
27412786
reach
"Because both eIF4AII and eIF4GII affected not only CACNA1A IRES driven translation of alpha1ACT but also cap dependent translation of full-length alpha1A (XREF_FIG), we used IRES-alpha1ACT vectors (XREF_SUPPLEMENTARY) to test the binding affinities of eIF4AII and eIF4GII to CACNA1A IRES."
27412786
reach
"We identified miR-3191-5p as a microRNA (miRNA) that targeted CACNA1A IRES and preferentially inhibited the CACNA1A IRES driven translation of alpha1ACT in an Argonaute 4 (Ago4)-dependent manner."
27412786
CACNA1A affects isocyanic acid
| 11
CACNA1A inhibits isocyanic acid. 11 / 11
| 11
sparser
"In all three genotypes, the voltage-dependent inactivation and deactivation of iCa were similar."
14594987
sparser
"The time constants rf and r~ may represent Ca2+- and voltage-dependent inactivation of Ica, respectively, whereas IB~ appeared to inactivate only by a voltage-dependent mechanism."
8549816
sparser
"Analysis of the It-Vc curve showed that cAMP enhanced both Ca(2+)-dependent and voltage-dependent inactivation of ICa."
1316558
sparser
"Barbiturates accelerated the decay phase of ICa at high concentrations (1 X 10(-4) to 3 X 10(-3) M), at which concentrations double-pulse experiments showed the increased rate of a voltage-dependent inactivation of ICa."
6100847
sparser
"Its vascular selectivity may be at least in part related to the marked voltage-dependent inhibition of ICa."
8773452
sparser
"These results indicate that the voltage-dependent inhibition of ICa by semotiadil may be due to binding of the ionized drug during the inactivated state and also inhibition of the transition from the inactivated to the resting state."
8483295
sparser
"These findings suggest that overdrive suppression in the SA node is, in part at least, the result of a rate- and voltage-dependent inactivation of iCa."
8945930
sparser
"It is concluded that the acceleration of the decay phase of ICa by barbiturates may be due to the increased rate of the voltage-dependent inactivation of ICa."
6100847
sparser
"Interestingly, the voltage-dependent inactivation of INa and ICa seemed to be more stable at high pressures compared to the activation parameters, as no significant changes were found up to a 20-MPa treatment."
12172643
sparser
"Cells loaded with these Ca chelators did not show any symptom of voltage dependent inactivation of ICa."
2409519
sparser
"This voltage-dependent block of iK is, therefore, opposite to the voltage-dependent inhibition of iCa produced by these compounds, where block of iCa is accentuated at positive membrane potentials."
2409272
CACNA1A affects G_protein
| 11
CACNA1A binds G_protein.
| 6
G_protein binds CACNA1A. 6 / 6
| 6
sparser
"The inhibition of Ca 2+ currents through P2Y12 receptors included a slowing of activation kinetics that is characteristic of the voltage-dependent interaction between G protein βγ subunits and channel proteins and was attenuated by pertussis toxin, but not by a phospholipase C inhibitor."
27172914
sparser
"Receptor activation subjects presynaptic N- and P/Q-type calcium channels to a rapid, membrane-delimited inhibition-mediated by direct, voltage-dependent interactions between G protein betagamma subunits and the channels-and to a slower, voltage-independent modulation involving soluble second messenger molecules."
17132857
sparser
"De Waard M, Liu H, Walker D, Scott VES, Gurnett CA and Campbell KP, Direct binding of G protein ß-y complex to voltage dependent calcium channels."
9278091
sparser
"It can be relieved by applying large positive pulses ( xref ; xref ; xref ), and is understood as direct voltage-dependent binding of G-protein βγ subunits to N-type (Ca V 2.2) and P/Q-type (Ca V 2.1) Ca 2+ channels ( xref ; xref ; xref )."
20670831
sparser
"None of the kinetic components depended on the way the channel was activated, or reflected a voltage-dependent interaction with a G protein; thus, the three kinetic components were interpreted as representing intrinsic gating and as reflecting three distinct closed or blocked states of the channel [39] ."
9429760
sparser
"Direct interaction with the β subunit of the heterotrimeric G protein complex causes voltage-dependent inhibition of N-type calcium channels."
20181083
CACNA1A inhibits G_protein.
| 4
CACNA1A inhibits G_protein. 4 / 4
| 4
sparser
"We thereby propose that the NT inhibitory module is indeed central to the voltage-dependent G protein inhibition of N-type Ca channels."
15953418
sparser
"Remarkably, the invertebrate LCa(v)2 channel from the pond snail, Lymnaea stagnalis, does not bear any of the hallmarks of mammalian, voltage-dependent G-protein inhibition of Ca(v)2.2."
20511524
sparser
"From our data it is apparent that either av, or ~B Ca2+ channels expressed alone are sufficient for Ca2+ voltage-dependent G protein inhibition, a~c channels ex- pressed alone do not exhibit the G protein inhibition seen in CILIA and am channels."
7664882
sparser
"An allosteric model for the voltage-dependent G-protein inhibition of VGCC."
22981275
CACNA1A activates G_protein.
| 1
CACNA1A activates G_protein. 1 / 1
| 1
sparser
"These results show that, (a) persistent activation of muscarinic M2 muscarinic receptors caused the increase in oscillatory frequency previously shown in PPN neurons ( xref ), and (b) an intracellular mechanism involving voltage-dependent activation of G-proteins mediated this increase in oscillatory frequency."
24223570
Ion channel affects CACNA1A
| 10
Ion channel binds CACNA1A.
| 8
CACNA1A binds ion channel. 8 / 8
| 8
sparser
"It was reported that pllp could form voltage-dependent and K(+)-selective ion channels in the membrane, or act as entry receptor for a kind endogenous retrovirous xref ."
23285140
sparser
"Here we introduce a new technique to monitor voltage-dependent charge displacement associated with Sh B-IR K + ion channels using RF electric fields during TEVC."
21387000
sparser
"The addition of a crude preparation of purified plasmolipin to lipid bilayers was able to induce the formation of voltage-dependent and potassium-selective ion channels in vitro ( Tosteson and Sapirstein, 1981 ), but the exact functional role of this intriguing protein in neural and non-neural tissues remains to be clarified."
9168137
sparser
"The voltage-dependent formation of alamethicin ion channels has been described by different models [ 9 ]."
9733952
sparser
"Some of the interactions that are relevant from this study’s point of view are as follows: (1) low-density lipoprotein receptor-related protein (LRP) is an important receptor for apolipoprotein E in the brain and is responsible for apolipoprotein E trafficking in the neuronal cells. xref LRP is co-expressed with Apo E since it is the primary receptor for lipidated form of Apo E; (2) voltage-dependent ion channel interaction affects intra-neuronal Ca2+ concentration, thereby affecting dopamine release to into the synapse in Parkinson’s disease; (3) α-synuclein is involved in aggregation to form inclusion bodies called as Lewy body and is a pathological hall mark of Parkinson’s disease. xref xref – xref There is association between α-synuclein-related neurotoxicity and increased apolipoprotein E levels in Parkinson’s disease. xref "
30327579
sparser
"In contrast to the single inhibition pathway induced by direct voltage-dependent interactions between Gβγ subunits and ion channels, there appear to be multiple pathways that induce voltage-independent inhibition of neuronal Ca 2+ current via a number of second messengers and protein kinases [ xref , xref , xref ]."
26633526
sparser
"The formation of hippocampal synapses is associated with increased expression and activation of ligand-gated ion channels and voltage-dependent Ca 2+ channels, which increases the energy demand required to operate the ion-motive ATPases that restore the membrane potential xref ."
23212379
sparser
"It is therefore of interest to determine whether other members of Type-II positive allosteric modulator family facilitate similar voltage-dependent interactions between α7 nicotinic receptor-mediated ion channels and charged compounds including those (i.e., choline and bicuculline) tested in this study."
24036349
Ion channel inhibits CACNA1A.
| 1
Ion channel inhibits CACNA1A. 1 / 1
| 1
sparser
"Pharmacological studies with marine compounds affecting the CNS involve areas of neuropharmacology, such as those of stimulation of neurogenesis, modulation of receptors and voltage-dependent ion channels and enzymes inhibition [ xref ]."
24798925
Ion channel activates CACNA1A.
| 1
Ion channel activates CACNA1A. 1 / 1
| 1
sparser
"Our data contribute to the accumulating knowledge of voltage-dependent ion channel activation by adding functional information about the effects of so-called non–voltage-sensing residues on VSD dynamics."
29321262
CACNA1A affects sodium(1+)
| 10
CACNA1A inhibits sodium(1+).
| 8
CACNA1A inhibits sodium(1+). 8 / 8
| 8
sparser
"LTG preferentially inhibits neuronal hyperexcitability and modifies synaptic plasticity via use- and voltage-dependent inhibition of neuronal voltage-activated Na+ channels and possibly high-voltage-activated Ca>cf6>2+>cf1> channels."
9778599
sparser
"Plateau potentials with a low threshold were also Na+ dependent, but these long-lasting potentials are probably produced by activation of a voltage-dependent non-inactivating Na+ conductance."
2425083
sparser
"Ragsdale, D.S., T. Scheuer and W.A. Catterall, 1991, Frequency and voltage-dependent inhibition of Type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic and anticonvulsant drugs, Mol."
8440304
sparser
"Voltage-dependent inactivation of fast Na+ channels during depolarization (reduction in MDP) by the Ca2+ channel blockers explains their inhibitory effect on +Vmax and indicates that L-type Ca2+ channels had no significant role in the upstroke."
8876052
sparser
"Voltage-dependent inactivation of Na+ channels is a consequence of voltage-dependent activation, and an inactivated Na+ channel enters a non-conducting and non-transmitting signals state, as the inactivation gate, the cytoplasmic loop linking domains III and IV of the α subunit, obstructs the open pore [ xref ]."
26747084
sparser
"In companion "whole-cell" voltage-clamp experiments on canine B cells, the underlying Na+ current displays steep voltage-dependent activation and inactivation over the range of -50 to -40 mV."
2167377
sparser
"The action potentials and the subthreshold spikelets were shown to be Na+ dependent and are presumably generated by a voltage-dependent inactivating Na+ conductance."
2425083
sparser
"In this study, we have made patch-clamp recordings from cultured HPP myotubes and found a defect in the normal voltage-dependent inactivation of Na+ channels."
1849724
CACNA1A activates sodium(1+).
| 2
CACNA1A activates sodium(1+). 2 / 2
| 2
sparser
"These results demonstrate that the algogenic peptide ET-1 induces ET(A) receptor-mediated, hyperpolarizing shifts in the voltage-dependent activation of TTX-R Na+ channels, a potential mechanism for selective excitation by ET-1 of nociceptors that we observed in vivo."
12151509
sparser
"In companion "whole-cell" voltage-clamp experiments on canine B cells, the underlying Na+ current displays steep voltage-dependent activation and inactivation over the range of -50 to -40 mV."
2167377
CACNA1A affects NMDAR
| 10
CACNA1A activates NMDAR.
| 6
CACNA1A activates NMDAR. 6 / 6
| 6
sparser
"A slow mode, which is seen in the isolated hemicord activated with NMDA, depends on slow bursting sustained by the voltage-dependent activation of NMDA receptors, while a fast mode is seen during application of d -glutamate and does not require NMDA voltage-dependent activation ( xref )."
21111210
sparser
"NMDA receptors directly gate calcium flux while AMPA receptors indirectly control calcium by regulating the voltage-dependent activation of NMDA receptors and voltage-sensitive calcium channels."
12951163
sparser
"The glutamate stimulates distal dendritic AMPA receptors to increase spontaneous EPSCs and enabled a voltage-dependent activation of neuronal NMDA receptors."
11976371
sparser
"On the other hand, epileptogenic transformation of the intact hippocampal neuronal network required voltage-dependent activation of NMDA-Rs and long-term alterations in GABAergic synapses, which became excitatory because of a positive shift in the chloride reversal potential ( xref )."
20810895
sparser
"Instead, it shows that the outward rectification of synaptic α5-GABA A Rs is essential to counteract the slow and voltage-dependent activation of NMDARs above –50 mV."
30177704
sparser
"As we were not able to block this component, we could not test or rule out a potential contribution to voltage-dependent activation of NMDA receptors in the young neurons."
28826488
CACNA1A inhibits NMDAR.
| 3
CACNA1A inhibits NMDAR. 3 / 3
| 3
sparser
"Magnesium prevents excitotoxic calcium-induced injury [ xref ], by a non-competitive voltage-dependent inhibition of the N-methyl-D-aspartate receptor to glutamate reducing calcium entry into the cell [ xref ]."
23570677
sparser
"A voltage-dependent inhibition of NMDAR could be observed at higher concentrations of zinc (>20  μ M) and was believed to be due to binding of the cation within the channel pore [ xref ]."
21197404
sparser
"Magnesium prevents excitotoxic calcium-induced injury [ xref ], by a non-competitive voltage-dependent inhibition of the N-methyl-D-aspartate receptor to glutamate which reduces calcium entry into the cell [ xref ]."
22587882
CACNA1A binds NMDAR.
| 1
CACNA1A binds NMDAR. 1 / 1
| 1
sparser
"In addition, these neuronal adenylyl cyclases are viewed as coincidence detectors due to their specific interaction with NMDA receptors and voltage-dependent calcium channels at the neuronal membrane."
16503978
CACNA1A affects NAV1
| 10
CACNA1A activates NAV1.
| 7
CACNA1A activates NAV1. 7 / 7
| 7
sparser
"Navβ2 causes a depolarizing shift in Nav1.1 and Nav1.6 (encoded by SCN8A ) voltage dependent activation and inactivation [ xref , xref ]."
29245901
sparser
"However, the voltage-dependent activation of Nav1.8 in neurons treated with PBS (V 1/2  = −10.2 ± 0.1 mV; slope k  = 5.1 ± 0.1 mV) was not significantly different from that with CXCL13 at 10 ng/ml (V 1/2  = −9.3 ± 0.2 mV; k  = 3.9 ± 0.2 m."
27708397
sparser
"In this study, the effects of BmK AS, a sodium channel-specific modulator from Chinese scorpion Buthus martensi Karsch, on the voltage-dependent activation and inactivation of Nav1.2 were examined before and after PKA activation."
24430351
sparser
"Whole cell patch studies revealed little change in voltage dependent activation and deactivation of Nav1.9, but significant increases in the amplitude of Nav1.9 were observed 8weeks after exposure."
24732443
sparser
"The influence of permethrin on AP duration, after hyperpolarization, spontaneous activity, half-activation potential (V1/2) and taudeact were reduced, but not fully reversed, when tests were conducted at 35 °C. In conclusion, permethrin greatly modifies the voltage dependent activation and deactivation of Nav1.8 expressed in skin, muscle and vascular nociceptors."
23701970
sparser
"G(V) relationship indicated that BmK I shifted voltage-dependent activation of Nav1.8 in a hyperpolarizing direction (Fig.  xref A)."
25903152
sparser
"While the voltage-dependent activation of Nav1.5 or Nav1.7 was not affected by mexiletine and lidocaine, the steady-state fast and slow inactivation of Nav1.5 and Nav1.7 were significantly shifted to hyperpolarized direction by either mexiletine or lidocaine in dose-dependent manner."
26068619
CACNA1A inhibits NAV1.
| 3
CACNA1A inhibits NAV1. 3 / 3
| 3
sparser
"Navβ2 causes a depolarizing shift in Nav1.1 and Nav1.6 (encoded by SCN8A ) voltage dependent activation and inactivation [ xref , xref ]."
29245901
sparser
"The mutant FHF1 proteins had a strong gain-of-function phenotype in transfected Neuro2A cells, enhancing the depolarizing shifts in Nav1.6 voltage-dependent fast inactivation, predicting increased neuronal excitability."
27164707
sparser
"In this study, the effects of BmK AS, a sodium channel-specific modulator from Chinese scorpion Buthus martensi Karsch, on the voltage-dependent activation and inactivation of Nav1.2 were examined before and after PKA activation."
24430351
CACNA1A affects Ile-Ala
| 9
CACNA1A inhibits Ile-Ala.
| 8
CACNA1A inhibits Ile-Ala. 8 / 8
| 8
sparser
"Our results indicate that fluoxetine produces a concentration- and voltage-dependent inhibition of IA, and that this effect could affect the excitability of hippocampal neurons."
15276879
sparser
"In addition, the voltage-dependent steady-state activation and inactivation of IA were altered in interneurons after CIE."
23889304
sparser
"Voltage-dependent steady-state inactivation of peak IA was described by a Boltzmann function with a slope factor of 8.4 mV and half-inactivation occurring at -78.8 mV."
8394414
sparser
"As shown in previous studies, the cannabinoid agonist WIN 55,212-2 increased IA via a decrease in steady-state voltage-dependent inactivation of IA."
7538581
sparser
"Consistent with voltage-dependent inactivation of IA, these correlations decrease with depolarization in brighter backgrounds."
30049678
sparser
"Inhibition of IA by DHPs was not accompanied by changes in the voltage-dependent steady state inactivation of IA or the kinetics of recovery subsequent to repolarization."
7969054
sparser
"Voltage-dependent steady-state inactivation of peak IA was described by a Boltzman function with a slope factor (k) of -6.5 and half-inactivation (V1/2) occurring at -75 mV."
1662262
sparser
"The NMDAR-IA functional coupling resulted from activation of extrasynaptic NMDARs, was calcium- and protein kinase C-dependent, and involved enhanced steady-state, voltage-dependent inactivation of IA."
24835172
CACNA1A activates Ile-Ala.
| 1
CACNA1A activates Ile-Ala. 1 / 1
| 1
sparser
"In addition, the voltage-dependent steady-state activation and inactivation of IA were altered in interneurons after CIE."
23889304
CACNA1A affects Sodium_channels
| 8
CACNA1A activates Sodium_channels.
| 4
CACNA1A activates Sodium_channels. 4 / 4
| 4
sparser
"Interestingly, an even greater (25 mV) shift in the voltage-dependent activation of the rat α-subunit sodium channel is caused by a leucine to phenylalanine mutation in the S4 segment (the voltage sensor) of domain II of this subunit (mutation introduced as a possible PCR error) [29] ."
9280307
sparser
"Subsequently, a calcium wave is retrogradely propagated to the soma by voltage-dependent sodium channel activation of a transient calcium current. xref Calcium transients also correlate with regenerative growth and this growth depends, in part, on a dual leucine kinase-1 (DLK-1), a conserved member of the mitogen-activated protein kinase (MAPK) pathway, in Caenorhabditis elegans . xref This kinase has also been found to be required for growth cone formation and regeneration throughout the C. elegans life cycle xref and in drosophila. xref In mice, depletion of DLK-1 sensory neuron outgrowth in vitro and phosphorylation of c-jun in vivo are reduced. xref The effect of DLK-1 may be mediated by enhancement of CCAAT/enhancer-binding protein-1 (C/EBP-1) mRNA stability. xref Calcium, therefore, quickly signals acute axonal injury and, in part, initiates a regenerative response through DLK-1."
22292105
sparser
"Overall, the data supports a working model in which all four S4 segments contribute to voltage-dependent activation of the sodium channel."
9379171
sparser
"The S4 segments in each domain function as voltage sensors for voltage-dependent activation of the sodium channel."
10514834
Sodium_channels binds CACNA1A. 3 / 3
| 3
sparser
"A fragment of paralytic (para), a voltage dependent sodium channel gene associated with insecticide resistance and courtship song production in Drosophila, was isolated and used as a molecular marker to study the divergence between two sympatric siblings of the L. longipalpis complex from Sobral, Brazil."
19057828
sparser
"It is concluded that the purified sodium channel contains the receptor site for LqTx in functional form and that restoration of high affinity, voltage-dependent binding of LqTx by the purified sodium channel requires an appropriate ratio of PC to PE and/or phosphatidylserine in the vesicle membrane."
2413014
sparser
"Phe1752 is a target for binding of high affinity voltage-dependent sodium channel inhibitors ( xref )."
26807988
CACNA1A inhibits Sodium_channels.
| 1
CACNA1A inhibits Sodium_channels. 1 / 1
| 1
sparser
"Free Zn 2+ deficiency 1) markedly reduced the neuronal survival rate, 2) reduced the peak amplitude of I Na , 3) shifted the I Na activation curve towards depolarization, 4) modulated the sensitivity of sodium channel voltage-dependent inactivation to a depolarization voltage, and 5) increased the time course of recovery from sodium channel inactivation."
28347465
CACNA1A affects CAV1
| 8
CACNA1A inhibits CAV1.
| 6
CACNA1A inhibits CAV1. 6 / 6
| 6
sparser
"The underlying mutations reduce voltage-dependent inactivation of Cav1.2. xref In the heart depolarizing Ca 2+ current increases, causing delayed cardiomyocyte repolarization, prolongation of the QT-interval and enhances the risk for lethal ventricular arrhythmias."
26039257
sparser
"Mutations within the CaN binding motif, A1929P, or H1926A/H1927A, accelerate the rate of Cav1.2 voltage-dependent inactivation."
22511998
sparser
"Voltage-dependent inactivation of Cav1.2 develops during the plateau phase of the cardiac action potential (AP) and enables timed repolarization and tuned calcium entry."
28766141
sparser
"In the present study, we investigate the role of S4 charges in voltage-dependent inactivation of Cav1.2."
28766141
sparser
"Taken together, we identified a dominant role of segment IS4 in voltage-dependent inactivation of Cav1.2."
28766141
sparser
"Our results reveal a novel critical extracellular determinant of current density for all Cav family members and of voltage-dependent inactivation of Cav1.3 and Cav2.1 channels."
30054272
CACNA1A activates CAV1.
| 2
CACNA1A activates CAV1. 2 / 2
| 2
sparser
"We conclude that exon 47 encodes structural determinants that regulate CDI and voltage-dependent activation of Cav1.4, and is necessary for modulation of channel activation by CaBP4."
27226626
sparser
"We previously documented the hyperpolarizing shift in the voltage-dependent activation of Cav1.3 compared with Cav1.2 Ca2+ channel subunits in a heterologous expression system."
16172271
Calcium(2+) affects CACNA1A
| 1 7
Calcium(2+) activates CACNA1A.
| 1 4
Calcium(2+) activates CACNA1A. 4 / 4
| 1 4
sparser
"We further mechanistically evaluated this premise using an allosteric model of voltage-dependent Ca V activation."
27481713
sparser
"The proteins were injected together with 100 mM BAPTA, and thus, should be in the apo-forms and remain so until the local calcium concentration is raised via voltage-dependent Ca V 1.2 activation."
23811053
sparser
"It has been hypothesised that in the aged hippocampus long-term potentiation expression is more dependent on voltage-dependent Ca channel activation than in the young brain ()."
10422760
sparser
"As previously observed for the skeletal muscle CRC (), a strong voltage-dependence of channel activities was observed in the presence of elevated levels of lumenal, but not cytosolic, Ca. A voltage-dependent activation by lumenal Ca was observed in the absence of caffeine provided sufficiently high cytosolic [Ca] was used to partially open the channel, which suggested that other channel activators such as sulmazole () or ATP () were not required for cardiac channel activation by lumenal Ca. In the absence of caffeine and with cytosolic [Ca] of <0.1 M in the presence () and absence () of 5mM MgATP, the cardiac CRC rarely opened."
9788925
Calcium(2+) inhibits CACNA1A.
| 3
Calcium(2+) inhibits CACNA1A. 3 / 3
| 3
sparser
"Switching to the b mode could decrease short-term depression by eliminating the contribution due to voltage-dependent Ca V 2.1 inactivation and also by decreasing the number of vesicles released per action potential, thus slowing down vesicle depletion."
15504897
sparser
"Alpha(1A(A454T)) channels showed weakened regulation of voltage-dependent steady-state inactivation by Ca(V)beta subunits."
20080591
sparser
"Applicationof aphysiologicalvoltagecommandisneededtoreproducethe physiological extent and time dependence of Ca versus 141 Volume66 January 1994 voltage-dependent Ca current inactivation, both of which maybesignificantindetermining1 cellelectricalbehavior."
8130333
CALM affects CACNA1A
| 1 7
CALM binds CACNA1A. 7 / 7
| 1 7
sparser
"Calcium channel blocker binding to calmodulin not only produces vasodilation but by preventing the phos- pholipase activation also acts to stabilize plasma membranes and lysosomal membranes, This in- tracellular calcium-mediated mechanism may ex- plain the direct action of nitrendipine in vitro on cathepsin D activity and proteolysis as well as the beneficial actions we report in vivo during oligemia."
6698110
sparser
"Here, we show that the eagD and cNBHD interact to modulate Ca 2+ -calmodulin as well as voltage-dependent gating."
27325704
sparser
"In contrast, SK Ca channels are not voltage dependent and their agonists interact with their Ca 2+ sensor calmodulin in the C-terminus region; however, at least for NS8593, the SK Ca -mediated gating modulation occurs via interaction with gating structures near the selectivity filter within the inner pore vestibule. xref "
28777255
sparser
"This study describes two classes of proteins, stac and fhf, interfere with CaM binding to voltage-dependent Ca and Na channels, both of which have a CaM binding domain that stacs and fhfs can also bind, thereby reducing Ca-dependent inactivation."
30198845
sparser
"Understanding the mechanisms leading to the DIDS-induced changes in RyR function is important, as these ligands have been suggested to interact with sites involved in voltage-dependent channel regulation ( Zahradníková and Zahradník, 1993 ), pH-dependent gating changes ( Zahradníková and Zahradník, 1993 ), and calmodulin binding ( Klinger et al., 1999 )."
12023226
sparser
"Its protein product interacts with calmodulin and calcium channel proteins."
24717675
sparser
"However, Pilla et al. [ xref ] held the view that the proposed mechanism resulted from an EMF effect on voltage-dependent Ca 2+ binding to CaM."
28729909
CACNA1A affects KCN
| 7
CACNA1A activates KCN.
| 4
CACNA1A activates KCN. 4 / 4
| 4
sparser
"Voltage-dependent activation of the inward-rectifier potassium channel in the ventricular cell membrane of guinea-pig heart."
7813010
sparser
"Kurachi Y. (1985) Voltage-dependent activation of the inward rectifier potassium channel in the ventricular cell membrane of guinea pig heart."
7845550
sparser
"KCNT1 encodes a weakly voltage dependent and intracellular sodium activated potassium channel."
24591078
sparser
"Functional studies of this variant showed a positive shift in voltage dependent activation of the slow potassium channel (I Ks ) and defects in trafficking KCNQ1. xref "
23861362
CACNA1A binds KCN.
| 3
KCN binds CACNA1A and KCNA1. 1 / 1
| 1
sparser
"This manuscript showed that mutations in the voltage-dependent delayed rectifier potassium channel gene, KCNA1, associated with episodic ataxia cause loss, alteration and dominant-negative suppression of channel function."
8791523
KCN binds CACNA1A and NRPS3. 1 / 1
| 1
sparser
"In addition to the potential effect of polymorphisms in drug metabolizing enzymes, genetic polymorphisms in components of the L-type calcium channel ( CANC1C , CACN1D ) and the large-conductance calcium and voltage-dependent potassium channel ß1 subunit gene ( KCNMB1 ) are associated with responsiveness and risk of cardiovascular side effects in patients taking calcium channel blockers for hypertension xref – xref ."
25282474
KCN binds CACNA1A, FOXH1, and IK. 1 / 1
| 1
sparser
"In Drosophila neurons the fast component of I K has been associated with the voltage-dependent potassium channel gene Shal ( Shaker cognate I ) ( xref ) and the voltage-dependent and calcium-activated potassium channel gene slowpoke ( slo ) ( xref )."
18305244
CACNA1A affects CALM
| 1 7
CALM binds CACNA1A. 7 / 7
| 1 7
sparser
"Calcium channel blocker binding to calmodulin not only produces vasodilation but by preventing the phos- pholipase activation also acts to stabilize plasma membranes and lysosomal membranes, This in- tracellular calcium-mediated mechanism may ex- plain the direct action of nitrendipine in vitro on cathepsin D activity and proteolysis as well as the beneficial actions we report in vivo during oligemia."
6698110
sparser
"Here, we show that the eagD and cNBHD interact to modulate Ca 2+ -calmodulin as well as voltage-dependent gating."
27325704
sparser
"In contrast, SK Ca channels are not voltage dependent and their agonists interact with their Ca 2+ sensor calmodulin in the C-terminus region; however, at least for NS8593, the SK Ca -mediated gating modulation occurs via interaction with gating structures near the selectivity filter within the inner pore vestibule. xref "
28777255
sparser
"This study describes two classes of proteins, stac and fhf, interfere with CaM binding to voltage-dependent Ca and Na channels, both of which have a CaM binding domain that stacs and fhfs can also bind, thereby reducing Ca-dependent inactivation."
30198845
sparser
"Understanding the mechanisms leading to the DIDS-induced changes in RyR function is important, as these ligands have been suggested to interact with sites involved in voltage-dependent channel regulation ( Zahradníková and Zahradník, 1993 ), pH-dependent gating changes ( Zahradníková and Zahradník, 1993 ), and calmodulin binding ( Klinger et al., 1999 )."
12023226
sparser
"Its protein product interacts with calmodulin and calcium channel proteins."
24717675
sparser
"However, Pilla et al. [ xref ] held the view that the proposed mechanism resulted from an EMF effect on voltage-dependent Ca 2+ binding to CaM."
28729909
Sodium_channels affects CACNA1A
| 6
Sodium_channels binds CACNA1A. 3 / 3
| 3
sparser
"A fragment of paralytic (para), a voltage dependent sodium channel gene associated with insecticide resistance and courtship song production in Drosophila, was isolated and used as a molecular marker to study the divergence between two sympatric siblings of the L. longipalpis complex from Sobral, Brazil."
19057828
sparser
"It is concluded that the purified sodium channel contains the receptor site for LqTx in functional form and that restoration of high affinity, voltage-dependent binding of LqTx by the purified sodium channel requires an appropriate ratio of PC to PE and/or phosphatidylserine in the vesicle membrane."
2413014
sparser
"Phe1752 is a target for binding of high affinity voltage-dependent sodium channel inhibitors ( xref )."
26807988
Sodium_channels activates CACNA1A.
| 3
Sodium_channels activates CACNA1A. 3 / 3
| 3
sparser
"Furthermore, the possible RRF release by voltage-dependent sodium channel activation and the calcium-dependency of the RRF release was investigated. mouse femoral arteries were mounted in myograph baths for in vitro isometric tension measurements."
29966443
sparser
"Phoneutria nigriventer venom (PNV)* contains several toxins that exert important biological effects such as voltage-dependent sodium channel activation [6, 7], local edema formation in vivo [8], and vascular smooth muscle contractions [9, 10]."
8216354
sparser
"Muscle contraction occurs when the summation of acetylcholine receptor activation reaches the threshold to trigger voltage dependent sodium channel activation in the sarcolemma outside the neuromuscular junction and subsequent action potential generation and depolarization of the muscle fiber."
25574501
CACNA1A affects vraC
| 6
CACNA1A inhibits vraC. 6 / 6
| 6
sparser
"Voltage-dependent Inhibition of VRAC with Extracellular ATP in BAEC."
12034759
sparser
"Mutations in EL1 also drastically affected voltage-dependent inactivation of VRAC ( xref )."
29925591
sparser
"Voltage-dependent inactivation of VRAC in cells exposed either to MβCD:cholesterol complexes, cholesterol-free MβCD, as well as control cells are shown in xref ."
10736308
sparser
"Chimeras between the poorly inactivating LRRC8C and the rapidly inactivating LRRC8E isoforms were used to pinpoint residues involved in the voltage-dependent inactivation of VRAC ( xref )."
29925591
sparser
"These studies also show that I Cln protein is not likely to contribute to a difference in the voltage-dependent inactivation of VRAC reported in many cell types."
10825435
sparser
"Voltage-dependent inactivation of VRAC develops only at voltages more positive than +40 or +60 mV and therefore is not likely to be physiological."
10736308
CACNA1A affects SCA6
| 6
CACNA1A activates SCA6. 6 / 6
| 6
reach
"XREF_BIBR SCA1, SCA2, Machado-Joseph or SCA3, SCA6, SCA7, SCA12, SCA17, and dentatorubral-pallidoluysian atrophy (DRPLA) are caused by (CAG) n repeat expansions in the ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, PPP2R2B, TBP, and ATN1 genes, respectively, and all lead to the expansion of a polyglutamine tract in the corresponding proteins."
24780882
reach
"Glutamine encoding CAG-repeat expansion in the C terminus of CACNA1A causes SCA6 XREF_BIBR."
23441182
reach
"SCA6 is allelic with EA2 and FHM type 1 and is caused by expansions of the CAG repeat sequence in the 3 ' end of CACNA1A."
26558925
reach
"SCA6 is caused by a CAG-repeat expansion in the gene CACNA1A encoding the alpha1A-subunit of voltage dependent P/Q-type calcium channel, causing a polyglutamine (poly-Q) expansion."
26730403
reach
"A CAG expansion in CACNA1A causes SCA6."
19345087
reach
"SCA6 is caused by an expanded CAG repeat in the CACNA1A gene, which results in an expanded polyglutamine (polyQ) tract."
27412786
CACNA1A affects Episodic ataxia type 2
| 6
CACNA1A activates Episodic ataxia type 2. 6 / 6
| 6
reach
"Episodic ataxia type 2 is caused by mutations in CACNA1A, which encodes the pore forming subunit of the neuronal voltage gated calcium channel Cav2.1."
26912519
reach
"Episodic ataxia type 2 (EA2) is caused by calcium channel (CACNA1A) mutations and typically begins before age 20 years."
16186543
reach
"Episodic ataxia type 2 (EA-2) is caused most frequently by CACNA1A frameshift mutations or truncations as well as missense mutations that result in Cav2.1 loss of function [XREF_BIBR - XREF_BIBR]."
24307138
reach
"Episodic ataxia type 2 is caused by mutations in CACNA1A, which encodes the pore forming subunit of the voltage gated calcium channel Ca v 2.1."
26912519
reach
"Episodic ataxia type 2 (EA2) is characterized by prolonged episodes of ataxia with interictal nystagmus and is caused by mutations in CACNA1A."
18541804
reach
"Episodic ataxia type 2 (EA2) is caused by mutations in CACNA1A."
19633872
CACNA1A affects CFI
| 6
CACNA1A activates CFI.
| 5
CACNA1A activates CFI. 5 / 5
| 5
sparser
"As shown in Figure 8 A, the β-adrenergic agonist isoprenaline shifted voltage dependent activation of I f in mock-infected embryonic atrial cardiomyocytes expressing green fluorescent protein (GFP) by 5.3 ± 0.5 mV (mean ± SEM of 15 cells)."
19555650
sparser
"Expression of PEX5R C terminally fused to GFP ( GFP PEX5R), however, completely prevented the isoprenaline-induced shift in voltage dependent activation of I f in these cells (ΔV 1/2 by isoprenaline of −0.3 ± 0.7 mV [n = 9]; p < 0.001 for the PEX5R mediated effect, Student's t test; Figure 8 B)."
19555650
sparser
"Though this is relatively smaller as compared to the ISO-induced shift (about +7 to +18 mV) of the I f activation curve in murine SAN cells (Alig et al., xref ; Baruscotti et al., xref ; Liao et al., xref ), it is close to observed values of 8.8 mV (Accili et al., xref ) and 5.3 mV (Accili et al., xref ) for a 1 μM ISO-induced shift in voltage-dependent activation of I f in adult rabbit SAN cells."
23060799
sparser
"cAMP potentiates voltage-dependent activation of I f either by binding directly to HCN4 channels ( xref ; xref ) or by protein kinase A (PKA)–mediated phosphorylation of HCN4 channels ( xref )."
28057842
sparser
"If the ratio of HCN2 over HCN4 transcript is also a contributing factor to the voltage-dependent activation of I f , an altered ratio of HCN2 over HCN4 should change I f ."
19236845
CACNA1A binds CFI.
| 1
CACNA1A binds HCN4 and CFI. 1 / 1
| 1
sparser
"In response to stress-associated β-adrenergic stimulation, cyclic AMP (cAMP) is generated which binds directly to HCN4 and increases I f by shifted voltage-dependent activation."
28573409
CACNA1A affects CABP1
2 2 | 2
CABP1 binds CACNA1A. 4 / 4
2 2 |
hprd
No evidence text available
14570872
biogrid
No evidence text available
11865310
hprd
No evidence text available
11865310
biogrid
No evidence text available
14570872
VSNL1 binds CABP1 and CACNA1A. 2 / 2
| 2
sparser
"These studies reveal that CaBP1 and VILIP-2 bind to the same site with opposite effects on Cav2.1."
30061813
sparser
"These results suggest a model in which nonmyristoylated CaBP1 and VILIP-2 bind to CaV2.1 channels and regulate them like CaM, whereas myristoylation allows differential, Ca2+-independent regulation by the inactive EF-hands of CaBP1 and VILIP-2, which differ in their positions in the protein structure."
16049184
CACNA1A affects ATXN3
| 4 2
CACNA1A binds ATXN3.
| 4 1
CACNA1A binds ATXN3. 3 / 3
| 2 1
reach
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A."
24534762
sparser
"Several autosomal dominant human neurological disorders are associated with mutations in the CACNA1A gene including; familial hemiplegic migraine, generalized epilepsy with ataxia, episodic ataxia type 2 and spinocerebellar ataxia type-6."
20043243
sparser
"Mutations in CACNA1A are also associated with other autosomal dominant neurological disorders characterized by cerebellar dysfunction, such as EA2 (Ophoff et al. xref )."
24498617
Calcium_channels binds Voltage_gated_ion_channels, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"Autosomal dominant mutations in the CACNA1A gene, which encodes the voltage-gated P/Q-type calcium channel alpha1 subunit, has also been associated with cerebellar ataxia, vertigo, epilepsy, and schizophrenia (see below) in addition to FHM (Lhatoo et al., xref )."
24312013
ATXN1 binds ATXN2, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A. Intermediate-length polyQ expansions (>24 Qs) of ATXN2 were found in 7 ADPD patients and no controls (7/299 = 2.34% and 0/329 = 0%, respectively; p = 0.0053 < 0.05/8 after Bonferroni correction)."
24534762
CACNA1A activates ATXN3.
| 1
CACNA1A activates ATXN3. 1 / 1
| 1
reach
"XREF_BIBR SCA1, SCA2, Machado-Joseph or SCA3, SCA6, SCA7, SCA12, SCA17, and dentatorubral-pallidoluysian atrophy (DRPLA) are caused by (CAG) n repeat expansions in the ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, PPP2R2B, TBP, and ATN1 genes, respectively, and all lead to the expansion of a polyglutamine tract in the corresponding proteins."
24780882
CABP1 affects CACNA1A
2 2 | 2
CABP1 binds CACNA1A. 4 / 4
2 2 |
hprd
No evidence text available
14570872
biogrid
No evidence text available
11865310
hprd
No evidence text available
11865310
biogrid
No evidence text available
14570872
VSNL1 binds CABP1 and CACNA1A. 2 / 2
| 2
sparser
"These studies reveal that CaBP1 and VILIP-2 bind to the same site with opposite effects on Cav2.1."
30061813
sparser
"These results suggest a model in which nonmyristoylated CaBP1 and VILIP-2 bind to CaV2.1 channels and regulate them like CaM, whereas myristoylation allows differential, Ca2+-independent regulation by the inactive EF-hands of CaBP1 and VILIP-2, which differ in their positions in the protein structure."
16049184
CACNA1A affects tDLN
| 5
CACNA1A activates tDLN. 5 / 5
| 5
reach
"B/I activated tDLN release IFN-gamma in response to tumor challenge."
21050466
reach
"Adoptive transfer of B/I activated tDLN was effective at inducing 4T1 tumor regression in nude mice pre-treated with CYP but IL-2 was neither beneficial nor required (data not shown, [F (2,13) = 11.289, P = 0.0014])."
21050466
reach
"B/I activated tDLN demonstrate increased expression of message for cytolytic mediators."
21050466
reach
"One of the key potential advantages of B/I activation of tDLN is the ability of these cells to continue proliferating in adoptive hosts after AIT, without the need for exogenous cytokines or antigen vaccination."
21050466
reach
"To ascertain whether the proliferation we observed in vivo for B/I activated tDLN in TBH mice resulted simply from homeostatic proliferation after the CYP treatment or is enhanced by the prior B/I stimulation, freshly harvested tDLN were transferred into CYP pre-treated TBH mice and B/I activated tDLN were infused into similar hosts, with or without CYP pre-treatment."
21050466
CACNA1A affects hydrogen chloride
| 5
CACNA1A inhibits hydrogen chloride.
| 4
CACNA1A inhibits hydrogen chloride. 4 / 4
| 4
sparser
"As discussed in the companion papers ( xref ; xref ), one contributor in the CFTR pore may be arginine 347 in TM6, since mutations that remove positive charge at this position drastically reduce selectivity between Cl − and I − ( xref ), abolish voltage–dependent inhibition of Cl − currents by the lyotropic anion SCN − ( xref ), and reduce channel block by cytoplasmic disulfonic stilbenes ( xref )."
9379168
sparser
"The biophysical characteristics of an outwardly rectifying, time- and positive voltage-dependent inactivating Cl − current that is sensitive to both NPPB and DIDS is consistent with either I ClC3 or I Cl swell ( xref ; xref ; xref ; xref )."
18784301
sparser
"Here we report that BAPTA, EDTA and HEDTA produce fast, reversible, voltage-dependent inhibition of swelling-activated Cl(-) current (I(Cl,swell)) in LNCaP prostate cancer epithelial cells that is unrelated to their Ca(2+) binding."
12067708
sparser
"Although voltage-dependent inactivation of the volume-regulated Cl is not likely to be physiological in nonexcitable cells (), it can be used as a comparative criterion for currents carried by Cl or anion amino acids."
9649382
CACNA1A activates hydrogen chloride.
| 1
CACNA1A activates hydrogen chloride. 1 / 1
| 1
sparser
"The Cl- channel showed voltage-dependent activation and the channels exhibited long-lasting openings."
11891566
CACNA1A affects cell population proliferation
| 2 3
CACNA1A activates cell population proliferation. 3 / 3
| 3
reach
"The CCK-8 assays demonstrate Zn-HA and Bi-HA coatings showed no toxicity to MG63 cells, and the Zn-HA and Bi-HA 2 (Zn-HA : Bi-HA = 64:1) coating is more effective to enhance the proliferation of MG63 cells compared to other coatings."
32018139
reach
"REFERENCES Agrewala J. N., Vinay D. S., Joshi A. and Mishra G. C. (1994) A 150 kDa molecule of macrophage membrane stimulates interleukin-2 and interferon-gamma production and proliferation of ovalbumin specific CD4+ T cells."
8604218
reach
"MK performed B/I activation of T cells, flow cytometry, MLR, and BrdU proliferation assays; MG performed flow cytometry; LG performed B/I activation of T cells; KG participated in study design; HDB participated in study design and manuscript preparation; FMM participated in study design and data analysis; MHM designed the experiments, analyzed data, and prepared the manuscript."
19849846
CACNA1A inhibits cell population proliferation. 2 / 2
| 2
sparser
"12 Shultz, P.J. and Raij, L. (1990) Inhibition of human mesangial cell proliferation by calcium channel blockkes."
8402579
sparser
"Furthermore, HPCA inhibited the proliferation of PBMNCs dose-dependently; however, it stimulated IL-8 and IL-1β production in supernatants of mononuclear cells."
23773024
CACNA1A affects apoptotic process
| 5
CACNA1A activates apoptotic process. 5 / 5
| 5
reach
"Specific association of SCA6 pathology clearly implies that small CAG expansion of the CACNL1A4 gene disturbs normal functions of the alpha 1A Ca 2+ channel, and ultimately produce apoptosis of Purkinje cells and granule cells in the cerebellum."
9559993
reach
"Specific association of SCA6 pathology clearly implies that small CAG expansion of the CACNL1A4 gene disturbs normal functions of the alpha 1A Ca 2+ channel, and ultimately produce apoptosis of Purkinje cells and granule cells in the cerebellum."
9559993
reach
"The BI-TK and GCV treatment system exhibited a sustainable anti-tumor growth activity and induced apoptosis in bladder cancer tissues by inhibition of Prx-I through the NF-kappaB pathway."
24904997
reach
"The BI-TK and GCV system (group C) was shown to inhibit tumor growth and caused the apoptosis of tumor cells as assessed by in situ terminal transferase dUTP nick-end labeling assay."
23258087
reach
"We presume that BI-TK and GCV treatment system is able to prevent tumor growth and induce apoptosis in the rodent bladder cancer model by down-regulating Prx-I expression."
24904997
CACNA1A affects Porins
| 5
CACNA1A inhibits Porins.
| 4
CACNA1A inhibits Porins. 4 / 4
| 4
sparser
"The voltage-dependent inactivation of porins demonstrated that porins can exist in non-conducting, i.e. closed, forms, and set the stage for the discovery of other possible modulators of porin function."
19100346
sparser
"The voltage-dependent inactivation of porins demonstrated that porins can exist in non-conducting, i.e. closed, forms, and set the stage for the discovery of other possible modulators of porin function."
19100346
sparser
"Still, the voltage-dependent inactivation of porins is a robust phenomenon, shown to differ among different porins species, and affected by mutations at specific pore residues [ xref , xref – xref ]."
19100346
sparser
"Still, the voltage-dependent inactivation of porins is a robust phenomenon, shown to differ among different porins species, and affected by mutations at specific pore residues [ xref , xref – xref ]."
19100346
CACNA1A binds Porins.
| 1
Porins binds CACNA1A. 1 / 1
| 1
sparser
"The voltage dependent anionic channels (VDACs) also known as mitochondrial porins form channels in the outer mitochondrial membranes and act as primary pathway for the movement of metabolites across the outer membrane [ xref , xref , xref – xref ]."
24260034
CACNA1A affects Kir6
| 5
CACNA1A activates Kir6. 5 / 5
| 5
sparser
"Several observations confirm that voltage-dependent activation of Kir6.2[L157E] is due to channel gating, rather than an alternative mechanism such as relief of block, a voltage-dependent change in conductance, or activation of an alternative channel type in the patch."
20208975
sparser
"While not as dramatic as the voltage-dependent activation of Kir6.2[L157E], these features can be quite obvious and are exaggerated in modest inhibitory concentrations of ATP."
20208975
sparser
"Glutamate substitution at position 168 results in somewhat unusual effects on conduction, including intrinsic inward rectification (in the absence of intracellular blockers), but these do not resemble the unique voltage-dependent activation of Kir6.2[L157E]."
20208975
sparser
"The voltage-dependent activation of Kir6.2[L157E] likely arises from a state preference for one orientation of permeating ions over another (specifically, whether the cavity site is occupied is vacant)."
20208975
sparser
"Such a mechanism may also account for the voltage-dependent activation of Kir6.2[L157E]."
20208975
CACNA1A affects CTNNBL1
| 5
CACNA1A inhibits CTNNBL1.
| 3
CACNA1A inhibits CTNNBL1. 3 / 3
| 3
sparser
"By contrast, voltage protocols similar to those we employed for the study of I NaP voltage-dependent inactivation (see above) determined no appreciable ramp-dependent recovery from inactivation of I NaP ."
10498669
sparser
"The above data clearly pointed to the existence of a time- and voltage-dependent inactivation of I NaP ."
10498669
sparser
"The kinetic properties of I NaP voltage-dependent inactivation were then further characterized."
10498669
CACNA1A activates CTNNBL1.
| 2
CACNA1A activates CTNNBL1. 2 / 2
| 2
sparser
"These models, which can account for both intrinsic oscillatory bursting behaviors at the cellular level and network level observed experimentally [ xref , xref ], propose that bursting is initiated by a subthreshold voltage-dependent activation of I NaP ."
23254296
sparser
"The voltage-dependent activation of G NaP was characterized by fitting a sigmoidal curve to each trace (see Section Methods), obtaining a voltage for half activation ( V 0.5 ) of −52.2 ± 1.0 mV, a slope constant of 4.9 ± 0.4 mV and a maximal conductance plateau of 5.3 ± 0.5 nS reached at voltages above −40 mV ( n = 13; Figure xref )."
28337126
CACNA1A affects CD69
| 3 2
CACNA1A binds CD69.
| 3
CACNA1A binds CD69. 2 / 2
| 2
sparser
"Two well-established forms of episodic ataxia, EA1 and EA2, are caused by mutations in a voltage-gated potassium channel and calcium channel, respectively."
19726947
sparser
"There are two main forms of episodic ataxia—EA1 and EA2."
26558925
CACNA1A binds CD69 and KN. 1 / 1
| 1
sparser
"Interestingly, SNP_1217, SNP_1472, SNP_1665, SNP_1753, SNP_1835, SNP_1896, and the only InDel (InDel_8) were associated with variation in both KN and KNPR in both EA1 and EA2."
31481842
CACNA1A activates CD69.
| 2
CACNA1A activates CD69. 2 / 2
| 2
reach
"Mutations of KCNA1 and CACNA1A cause episodic ataxia 1 (EA1 : MIM # 160120) and episodic ataxia 2 (EA2 : MIM # 108500), respectively."
12736095
reach
"To date, eight types of EA have been described; the dominant forms are EA1 (OMIM, 160120) and EA2 (OMIM, 108500), caused by mutations in KCNA1 (OMIM, 176260) and CACNA1A (OMIM, 601011), respectively."
30314295
ATXN3 affects CACNA1A
| 4 1
CACNA1A binds ATXN3. 3 / 3
| 2 1
reach
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A."
24534762
sparser
"Several autosomal dominant human neurological disorders are associated with mutations in the CACNA1A gene including; familial hemiplegic migraine, generalized epilepsy with ataxia, episodic ataxia type 2 and spinocerebellar ataxia type-6."
20043243
sparser
"Mutations in CACNA1A are also associated with other autosomal dominant neurological disorders characterized by cerebellar dysfunction, such as EA2 (Ophoff et al. xref )."
24498617
Calcium_channels binds Voltage_gated_ion_channels, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"Autosomal dominant mutations in the CACNA1A gene, which encodes the voltage-gated P/Q-type calcium channel alpha1 subunit, has also been associated with cerebellar ataxia, vertigo, epilepsy, and schizophrenia (see below) in addition to FHM (Lhatoo et al., xref )."
24312013
ATXN1 binds ATXN2, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A. Intermediate-length polyQ expansions (>24 Qs) of ATXN2 were found in 7 ADPD patients and no controls (7/299 = 2.34% and 0/329 = 0%, respectively; p = 0.0053 < 0.05/8 after Bonferroni correction)."
24534762
Potassium(1+) affects CACNA1A
| 4
Potassium(1+) inhibits CACNA1A.
| 3
Potassium(1+) inhibits CACNA1A. 3 / 3
| 3
sparser
"A combination of both ATP-dependent channel inhibition by glibenclaminde and voltage-dependent K+ channel inhibition by 4-aminopyridine was necessary to fully inhibit the relaxation."
26799746
sparser
"Our data suggest that voltage-dependent K+ channel inhibition with 4-aminopyridine treatment restores blood pressure and increases survival in the Wistar rat model of anaphylactic shock."
27270180
sparser
"These results demonstrate enhanced voltage-dependent potassium current inactivation in SCA3 Purkinje neurons."
21900579
Potassium(1+) activates CACNA1A.
| 1
Potassium(1+) activates CACNA1A. 1 / 1
| 1
sparser
"In Myxicola axons ABA and IAA had no effect, while 2,4-D (10 uM) caused a depolarizing shift of voltage-dependent Na+ and K+ activation by 25 +/- 4 mV and 15 +/- 3 mV, consistent with internal negative surface charge changes of -0.002 e-/A2 and -0.0007 e-/A2."
2436618
MiR-3191-5p affects CACNA1A
| 4
MiR-3191-5p inhibits CACNA1A. 4 / 4
| 4
reach
"MiR-3191-5p inhibits the CACNA1A IRES driven translation of alpha1ACT while sparing alpha1A and CACNA1A mRNA expression."
27412786
reach
"Dual-luciferase assays revealed that miR-711, miR-3191-5p, and miR-4786-3p down-regulated CACNA1A IRES driven luciferase activities compared to a negative control miRNA (XREF_FIG)."
27412786
reach
"MiR-3191-5p inhibits the translational initiation of CACNA1A IRES driven alpha1ACT by eIF4AII and eIF4GII."
27412786
reach
"These results suggest that miR-3191-5p interacts with CACNA1A IRES only through its predicted binding site and inhibits the CACNA1A IRES driven translation of alpha1ACT while sparing alpha1A expression and CACNA1A mRNA expression."
27412786
Voltage_gated_ion_channels affects CACNA1A
| 4
Voltage_gated_ion_channels binds CACNA1A. 1 / 1
| 1
sparser
"We propose that this predictability is linked to the dynamics of a prominent low-threshold fast-inactivating voltage-gated potassium conductance interacting with voltage-dependent sodium conductance, including a persistent fraction, which enhances the activation of sodium channels around AP threshold ( xref and xref )."
27536875
Voltage_gated_ion_channels binds CACNA1A and CACNA1B. 1 / 1
| 1
sparser
"It is well accepted that certain hereditary forms of migraine are associated with polymorphisms of voltage-gated calcium channels Cav2.1 and Cav2.2 ( xref )."
24151455
Voltage_gated_ion_channels binds SNAP25 and CACNA1A. 1 / 1
| 1
sparser
"Previous studies have shown that SNAP-25 is associated with N and P/Q type voltage gated calcium channels [for review, see ref. [ xref ]], and specifically impedes calcium currents through P/Q type channels activated in response to action potential-like stimuli [ xref ]."
18959796
Calcium_channels binds Voltage_gated_ion_channels, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"Autosomal dominant mutations in the CACNA1A gene, which encodes the voltage-gated P/Q-type calcium channel alpha1 subunit, has also been associated with cerebellar ataxia, vertigo, epilepsy, and schizophrenia (see below) in addition to FHM (Lhatoo et al., xref )."
24312013
GNB1 affects CACNA1A
4 |
CACNA1A binds GNB1 and GNG2. 3 / 3
3 |
hprd
No evidence text available
9238069
hprd
No evidence text available
9009193
hprd
No evidence text available
12527722
CACNA1A binds GNB1. 1 / 1
1 |
hprd
No evidence text available
9009193
EIF4G3 affects CACNA1A
| 1 3
EIF4G3 activates CACNA1A.
| 3
EIF4G3 activates CACNA1A. 3 / 3
| 3
reach
"miR-3191-5p bound to Ago4 selectively inhibits the translational initiation of CACNA1A IRES driven alpha1ACT by eIF4AII and eIF4GII (XREF_SUPPLEMENTARY)."
27412786
reach
"We found that overexpression of either eIF4AII or eIF4GII, but not eIF4AI or eIF4GI, increased the CACNA1A IRES driven luciferase activities and that the effects of eIF4AII and eIF4GII were blocked by cotransfection with miR-3191-5p (XREF_FIG)."
27412786
reach
"miR-3191-5p inhibits the translational initiation of CACNA1A IRES driven alpha1ACT by eIF4AII and eIF4GII."
27412786
EIF4G3 binds CACNA1A.
| 1
CACNA1A binds EIF4A2 and EIF4G3. 1 / 1
| 1
sparser
"Ago4-bound miR-3191-5p blocked the interaction of eIF4AII and eIF4GII with the CACNA1A IRES, attenuating IRES-driven α1ACT translation."
27412786
EIF4A2 affects CACNA1A
| 1 3
EIF4A2 activates CACNA1A.
| 3
EIF4A2 activates CACNA1A. 3 / 3
| 3
reach
"We found that overexpression of either eIF4AII or eIF4GII, but not eIF4AI or eIF4GI, increased the CACNA1A IRES driven luciferase activities and that the effects of eIF4AII and eIF4GII were blocked by cotransfection with miR-3191-5p (XREF_FIG)."
27412786
reach
"miR-3191-5p inhibits the translational initiation of CACNA1A IRES driven alpha1ACT by eIF4AII and eIF4GII."
27412786
reach
"miR-3191-5p bound to Ago4 selectively inhibits the translational initiation of CACNA1A IRES driven alpha1ACT by eIF4AII and eIF4GII (XREF_SUPPLEMENTARY)."
27412786
EIF4A2 binds CACNA1A.
| 1
CACNA1A binds EIF4A2 and EIF4G3. 1 / 1
| 1
sparser
"Ago4-bound miR-3191-5p blocked the interaction of eIF4AII and eIF4GII with the CACNA1A IRES, attenuating IRES-driven α1ACT translation."
27412786
CACNA1A affects vdcC
| 4
CACNA1A inhibits vdcC.
| 3
CACNA1A inhibits vdcC. 3 / 3
| 3
sparser
"A very slow voltage-dependent inactivation of the presynaptic VDCC is generally overcome by a faster Ca2+-dependent inactivation process (Tareilus et al., 1994a)."
7670358
sparser
"In contrast to the rapid progress in exploring the structure/function relationship for channel inac- tivation in general, detailed information about the voltage-dependent inactivation of presynaptic VDCC is still rare."
7670358
sparser
"Electrophysiological analyses revealed that GLP-1 application enhanced L-type voltage-dependent Ca2+ channel (VDCC) currents > 2-fold and caused a positive shift in VDCC voltage-dependent inactivation in WT-GLP-1R cells only, not control or mutant (DM-1) cells."
10446905
CACNA1A binds vdcC.
| 1
CACNA1A binds RIMS1 and vdcC. 1 / 1
| 1
sparser
"RIM1 associated with VDCC beta-subunits via its C terminus to markedly suppress voltage-dependent inactivation among different neuronal VDCCs."
17496890
CACNA1A affects pyraclofos
| 1 3
CACNA1A inhibits pyraclofos.
| 1 1
CACNA1A inhibits pyraclofos. 2 / 2
| 1 1
sparser
"RESULTS Concentration- and voltage-dependent inhibition of high- voltage- activated (HVA) Ca2* channels by 5-HT To isolate the Ba2* current (/aa) passing through HVA Ca2* channels, the VMH neurons were held at a holding potential (Vu) of 50 mV by the use of a nystatin perforated-patch recording mode."
9121612
reach
"Episodic Ataxia type 2 (EA2) is the most frequent subtype of episodic ataxia caused by loss-of- function mutations in the CACNA1A gene encoding the alpha1A subunit of P/Q type voltage gated Ca 2+ channels (Ca v 2.1) mainly expressed in Purkinje and granule cells in the cerebellum."
27242528
CACNA1A activates pyraclofos.
| 2
CACNA1A activates pyraclofos. 2 / 2
| 2
reach
"Discussion Distinct Neuronal Call Channel Subunits Comprise a Novel DHP Sensitive Subtype Our results demonstrate that the a, p subunit mediates DHP- sensitive, high voltage activated, long lasting Ca 2+ channel activity."
1309651
reach
"The disease is genetically heterogeneous and is classified as episodic ataxia type 2 (EA2) when it is caused by a mutation in the CACNA1A gene, encoding the alpha 1A subunit of the P/Q-type voltage gated calcium channel Ca v 2.1."
28566750
CACNA1A affects hemiplegic migraine type 1
| 4
CACNA1A activates hemiplegic migraine type 1. 4 / 4
| 4
reach
"Familial hemiplegic migraine type 1 (FHM1) is caused by mutations in the CACNA1A gene, encoding neuronal presynaptic Ca (V) 2.1 (P/Q-type) Ca (2+) channels."
20631222
reach
"Familial hemiplegic migraine type 1 (FHM-1) is caused by mutations in CACNA1A, the gene encoding for the Ca (v) 2.1 subunit of voltage gated calcium channels."
18581134
reach
"Familial hemiplegic migraine type 1 (FHM1), a severe migraine with aura variant, is caused by mutations in the CACNA1A gene."
19847904
reach
"Familial hemiplegic migraine type 1 (FHM-1) is caused by mutations in the CACNA1A gene, with the R192Q mutation being the most common."
21893556
CACNA1A affects Voltage_gated_ion_channels
| 4
Voltage_gated_ion_channels binds CACNA1A. 1 / 1
| 1
sparser
"We propose that this predictability is linked to the dynamics of a prominent low-threshold fast-inactivating voltage-gated potassium conductance interacting with voltage-dependent sodium conductance, including a persistent fraction, which enhances the activation of sodium channels around AP threshold ( xref and xref )."
27536875
Voltage_gated_ion_channels binds CACNA1A and CACNA1B. 1 / 1
| 1
sparser
"It is well accepted that certain hereditary forms of migraine are associated with polymorphisms of voltage-gated calcium channels Cav2.1 and Cav2.2 ( xref )."
24151455
Voltage_gated_ion_channels binds SNAP25 and CACNA1A. 1 / 1
| 1
sparser
"Previous studies have shown that SNAP-25 is associated with N and P/Q type voltage gated calcium channels [for review, see ref. [ xref ]], and specifically impedes calcium currents through P/Q type channels activated in response to action potential-like stimuli [ xref ]."
18959796
Calcium_channels binds Voltage_gated_ion_channels, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"Autosomal dominant mutations in the CACNA1A gene, which encodes the voltage-gated P/Q-type calcium channel alpha1 subunit, has also been associated with cerebellar ataxia, vertigo, epilepsy, and schizophrenia (see below) in addition to FHM (Lhatoo et al., xref )."
24312013
CACNA1A affects Ile-His
| 4
CACNA1A activates Ile-His. 4 / 4
| 4
sparser
"Using the spared nerve injury (SNI) model of neuropathic pain in Long-Evans rats and patch-clamp recordings in layer II/III pyramidal neurons of the contralateral mPFC, we observed a hyperpolarizing shift in the voltage-dependent activation of Ih in SNI neurons, whereas maximal Ih remained unchanged."
26400952
sparser
"The increase in neuronal excitability persists with continuous PACAP exposure ( xref ; xref ; xref ) and is suggested to be due in part to increased adenylyl cyclase/cyclic AMP levels, which shift the voltage-dependent activation of the nonselective cationic Ih current ( xref ; xref )."
23467377
sparser
"Moreover, intracellular application of bromo-cAMP abolished the hyperpolarizing shift in the voltage-dependent activation of Ih observed in SNI neurons, whereas protein kinase A (PKA) inhibition further promoted this shift in both SNI and sham neurons."
26400952
sparser
"In addition, serotonin caused a depolarizing shift in the voltage-dependent activation of Ih."
25429115
CACNA1A affects INA
| 4
CACNA1A inhibits INA.
| 2
CACNA1A inhibits INA. 2 / 2
| 2
sparser
"The voltage-dependent inhibition of INa was associated with the shift of the INa availability curve to more negative potentials."
7528932
sparser
"Interestingly, the voltage-dependent inactivation of INa and ICa seemed to be more stable at high pressures compared to the activation parameters, as no significant changes were found up to a 20-MPa treatment."
12172643
CACNA1A binds INA.
| 1
CACNA1A binds INA. 1 / 1
| 1
sparser
"The voltage-dependent inhibition of INa was associated with the shift of the INa availability curve to more negative potentials."
7528932
CACNA1A activates INA.
| 1
CACNA1A activates INA. 1 / 1
| 1
sparser
"Effects of ethanol on the current-voltage relationship and voltage-dependent activation of INa. (A) shows families of INa elicited by test potentials applied from a holding potential of -120 mV to test potentials ranging from -60 to+20 mV in 10 mV steps."
7720786
CACNA1A affects GNB1
4 |
CACNA1A binds GNB1 and GNG2. 3 / 3
3 |
hprd
No evidence text available
9238069
hprd
No evidence text available
9009193
hprd
No evidence text available
12527722
CACNA1A binds GNB1. 1 / 1
1 |
hprd
No evidence text available
9009193
CACNA1A affects CD62L
| 4
CACNA1A activates CD62L. 4 / 4
| 4
reach
"Unsorted B/I activated lymphocytes, CD62L + cells that remained CD62L + after B/I and expansion (CD62L + --> CD62L +), CD62L + cells that downregulated CD62L after B/I treatment and expansion (CD62L + --> CD62L -), CD62L - cells that remained CD62L - after B/I treatment and expansion (CD62L - --> CD62L -), or CD62L - cells that upregulated CD62L expression after B/I and expansion (CD62L - --> CD62L +) were infused into CYP pre-treated tumor bearing mice."
21050466
reach
"In the 4T1 mammary carcinoma model which is very weakly immunogenic and aggressively metastatic, we have previously shown that B/I selectively activates CD62L - or sensitized T cells [XREF_BIBR]."
19826947
reach
"In the 4T1 mammary carcinoma model, we have shown that B/I selectively activates CD62L - or sensitized T cells and that the anti-tumor activity resides in the CD62L - fraction of lymphocytes obtained from donor lymph nodes; only the CD62L - subset proliferates after B/I activation and has anti-tumor activity [XREF_BIBR]."
21050466
reach
"B/I selectively activates CD62L - T cells, the " sensitized " T cells capable of anti-tumor activity."
28146052
CACNA1A affects ATP1A2
| 4
CACNA1A binds ATP1A2. 2 / 2
| 2
sparser
"Mutations in the CACNA1A and ATP1A2 genes are associated with familial hemiplegic migraine, a rare subtype of migraine with aura ."
16356649
sparser
"This disease has been associated with missense mutations in the CACNA1A and ATP1A2 genes."
17119788
SCN1A binds CACNA1A and ATP1A2. 1 / 1
| 1
sparser
"FHM may be associated with mutations in the genes CACNA1A (FHM1), ATP1A2 (FHM2) and SCN1A (FHM3) [ xref ]."
22661290
SCN1A binds CACNA1A, ATP1A2, and ATP1A2. 1 / 1
| 1
sparser
"Mutations in CACNA1A, ATP1A2 and SCN1A genes have been associated with familial hemiplegic migraine (FHM), a rare monogenic form of migraine [ xref ]."
23566281
Spermine affects CACNA1A
| 3
Spermine inhibits CACNA1A. 3 / 3
| 3
sparser
"Glycine-dependent stimulation is seen with NR1 A /NR2A and NR1 A /NR2B receptors, while voltage-dependent spermine inhibition occurs with similar magnitude in NR1 A /NR2A or NR1 A /NR2B receptors but is absent in NR1 A /NR2C receptors ( Williams, 1994b )."
10871702
sparser
"All NR1 slice variants when combined with the NR2A or NR2B exhibited voltage dependent inhibition by spermine whereas glycine-sensitive potentiation required the lack of the N-terminal cassette and was seen in either NR2A or NR2B containing receptors."
9680258
sparser
"In addition to stimulation, voltage-dependent inhibition by spermine was seen at native NMDA receptors in the absence of extracellular Mg 2+ , possibly representing a direct block of the ion channel by spermine [73, 75, 77, 78] ."
9067625
Sodium(1+) affects CACNA1A
| 3
Sodium(1+) activates CACNA1A.
| 2
Sodium(1+) activates CACNA1A. 2 / 2
| 2
sparser
"In Myxicola axons ABA and IAA had no effect, while 2,4-D (10 uM) caused a depolarizing shift of voltage-dependent Na+ and K+ activation by 25 +/- 4 mV and 15 +/- 3 mV, consistent with internal negative surface charge changes of -0.002 e-/A2 and -0.0007 e-/A2."
2436618
sparser
"The role of voltage-dependent Na+ channel activation in CHEB-evoked glutamate release was examined using Na4" channel blockers."
8887978
Sodium(1+) inhibits CACNA1A.
| 1
Sodium(1+) inhibits CACNA1A. 1 / 1
| 1
sparser
"Protein kinase C-medi- ated phosphorylation of voltage-dependent Na+ channels abolished fast inactivation (West et al., 1991), and PKA phosphorylationofL- typeCa2+channelsinducedashiftin gatingmodes(Yueetal.,1990)."
8580322
RHuR affects CACNA1A
| 3
CACNA1A binds rHuR. 3 / 3
| 3
reach
"Among the hits, Mitoxantrone revealed to be a compound interfering with rHuR binding to Bi-TNF in both of our in vitro assays."
23951323
reach
"Characterization of rHuR binding to Bi-TNF probe."
23951323
reach
"Time course experiments showed that binding of rHuR to Bi-TNF probe was both time and dose dependent (XREF_FIG)."
23951323
Buk affects CACNA1A
| 3
Buk activates CACNA1A.
| 2
Buk activates CACNA1A. 1 / 1
| 1
sparser
"Consistent with voltage-dependent BK Ca activation, an increase in holding voltage resulted in NPo increase ( xref )."
28327344
Buk activates CACNA1A. 1 / 1
| 1
sparser
"Consistent with voltage-dependent BK Ca activation, an increase in holding voltage resulted in NPo increase ( xref )."
28327344
Buk binds CACNA1A.
| 1
CACNA1A binds buk and buk. 1 / 1
| 1
sparser
"Direct interaction of Cav2.1 and BK proteins was also found by copurification of these two molecules from rat brain in tandem mass spectrometry ( xref )."
23426693
Trypsin affects CACNA1A
| 3
Trypsin inhibits CACNA1A.
| 2
Trypsin inhibits CACNA1A. 2 / 2
| 2
sparser
"Increase in current and selective removal of voltage-dependent inactivation by intracellular trypsin."
1664456
sparser
"Calciumcurrentsin the A7r5 smooth muscle-derived cell line: increase in current and selective removal of voltage-dependent inactivation by intracellular trypsin."
8580327
Trypsin binds CACNA1A.
| 1
Trypsin binds CACNA1A and SLC26A5. 1 / 1
| 1
sparser
"Because GFP alone did not bring about a voltage-dependent component in the membrane capacitance with or without intracellular trypsin treatment, the voltage-dependent component was associated with prestin."
14747354
SNAP receptor activity affects CACNA1A
| 3
SNAP receptor activity binds CACNA1A. 3 / 3
| 3
sparser
"Other studies have shown that the SNARE complexes also associate with P/Q type Ca 2+ channels in conjunction with synaptotagmin [88] ."
9223620
sparser
"One mechanism by which they act is through direct interaction of the Gβγ subunit with members of the SNARE complex downstream of voltage-dependent calcium channels, and specifically with the C-terminus of SNAP25 and the H3 domain of syntaxin1A(1-3)."
22368765
sparser
"One mechanism by which they act is through direct interaction of the Gβγ subunit with members of the SNARE complex downstream of voltage-dependent calcium channels, and specifically with the C-terminus of SNAP25 and the H3 domain of syntaxin1A xref - xref ."
22368765
RSD-4 affects CACNA1A
3 |
CACNA1A binds RSD-4. 3 / 3
3 |
biogrid
No evidence text available
28167673
biogrid
No evidence text available
28167673
biogrid
No evidence text available
28167673
NMDAR affects CACNA1A
| 3
NMDAR activates CACNA1A.
| 2
NMDAR activates CACNA1A. 2 / 2
| 2
sparser
"Because of the presence of NMDARs at many glutamatergic synapses, most studies find that NMDARs activate other voltage-dependent channels by boosting local synaptic depolarization (Schiller et al., xref ; Losonczy and Magee, xref ; Nevian et al., xref ; Makara et al., xref ; Branco and Häusser, xref ; Katona et al., xref ; Krueppel et al., xref )."
25852470
sparser
"This shows that the outward rectification of α5-GABA A Rs provides inhibitory GABAergic conductance on demand, perfectly suited to counterbalance voltage-dependent NMDAR activation with minimally affecting small AMPAR-mediated PSPs."
30177704
NMDAR binds CACNA1A.
| 1
CACNA1A binds NMDAR. 1 / 1
| 1
sparser
"In addition, these neuronal adenylyl cyclases are viewed as coincidence detectors due to their specific interaction with NMDA receptors and voltage-dependent calcium channels at the neuronal membrane."
16503978
CD69 affects CACNA1A
| 3
CACNA1A binds CD69. 2 / 2
| 2
sparser
"Two well-established forms of episodic ataxia, EA1 and EA2, are caused by mutations in a voltage-gated potassium channel and calcium channel, respectively."
19726947
sparser
"There are two main forms of episodic ataxia—EA1 and EA2."
26558925
CACNA1A binds CD69 and KN. 1 / 1
| 1
sparser
"Interestingly, SNP_1217, SNP_1472, SNP_1665, SNP_1753, SNP_1835, SNP_1896, and the only InDel (InDel_8) were associated with variation in both KN and KNPR in both EA1 and EA2."
31481842
CACNA1A affects rHuR
| 3
CACNA1A binds rHuR. 3 / 3
| 3
reach
"Among the hits, Mitoxantrone revealed to be a compound interfering with rHuR binding to Bi-TNF in both of our in vitro assays."
23951323
reach
"Characterization of rHuR binding to Bi-TNF probe."
23951323
reach
"Time course experiments showed that binding of rHuR to Bi-TNF probe was both time and dose dependent (XREF_FIG)."
23951323
CACNA1A affects mscS
| 3
CACNA1A inhibits mscS. 3 / 3
| 3
sparser
"In the present study, we investigated the role of arginine residues in TM1 and TM2 in the voltage-dependent inactivation of MscS."
28101504
sparser
"In conclusion, we have shown that the neutralization of the arginine residues in TM1 and TM2 does not influence the stretch activation and voltage-dependent inactivation of MscS."
28101504
sparser
"The movement of gating charges is of crucial importance for understanding the mechanism of voltage-dependent inactivation of MscS."
28101504
CACNA1A affects episodic ataxia type 2
| 3
Mutated CACNA1A activates episodic ataxia type 2. 3 / 3
| 3
reach
"Different mutations of the CACNA1A genes, which encode the immunogenic alpha-1A VGCC subunit (Ca v 2.1), can produce the autosomal dominant SCA type 6, episodic ataxia type 2 (EA2) or familial hemiplegic migraine 1 (FHM1)."
26377184
reach
"CACNA1A mutations underlie three allelic disorders : familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6."
30063100
reach
"In contrast, episodic ataxia type 2 is characterized by episodes of cerebellar ataxia, migraine, and interictal nystagmus, and is caused by nonsense mutations of CACNA1A."
18940563
CACNA1A affects cell differentiation
| 3
CACNA1A inhibits cell differentiation. 3 / 3
| 3
sparser
"Unexpectedly, MHP1 inhibited RANKL-induced osteoclast differentiation."
27897273
sparser
"Here we report that, in addition to inducing neurogenesis, HPCA inhibits astrocytic differentiation of neural stem cells."
28017654
sparser
"Finally, we examined whether MHP1 would affect osteoclast activation in the radial bone of paralyzed forelimbs because we previously reported that MHP1 could inhibit RANKL-induced osteoclast differentiation [ xref ]."
30151382
CACNA1A affects barium(2+)
| 2 1
CACNA1A inhibits barium(2+).
| 1 1
CACNA1A inhibits barium(2+). 2 / 2
| 1 1
sparser
"Electrophysiological analysis revealed that TSPAN-13 specifically modulates the efficiency of coupling between voltage sensor activation and pore opening of the channel and accelerates the voltage-dependent activation and inactivation of the Ba(2+) current through CaV2.2."
23648579
reach
"Infantis also limited Ba."
28976925
CACNA1A activates barium(2+).
| 1
CACNA1A activates barium(2+). 1 / 1
| 1
sparser
"Electrophysiological analysis revealed that TSPAN-13 specifically modulates the efficiency of coupling between voltage sensor activation and pore opening of the channel and accelerates the voltage-dependent activation and inactivation of the Ba(2+) current through CaV2.2."
23648579
CACNA1A affects anion
| 3
CACNA1A activates anion.
| 2
CACNA1A activates anion. 2 / 2
| 2
sparser
"In this study, we found that murine B cells express the voltage-dependent slowly activating anion channels (VSACs)."
16758225
sparser
"Voltage-dependent slowly activating anion current regulated by temperature and extracellular pH in mouse B cells."
16758225
CACNA1A binds anion.
| 1
Anion binds CACNA1A. 1 / 1
| 1
sparser
"GRP78 was shown to interact with JEV E protein by coimmunoprecipitation, and was additionally shown to interact with voltage dependent anion protein (VDAC) through the same methodology."
25126612
CACNA1A affects STAT3
| 3
CACNA1A dephosphorylates STAT3.
| 2
CACNA1A dephosphorylates STAT3. 2 / 2
| 2
sparser
"As shown in xref A, Hpca increased the dephosphorylation of p-STAT3(Y705) compared with the vector control, even in the absence of bFGF, but did not affect p-STAT3(S727)."
28017654
sparser
"Moreover, bFGF removal-induced p-STAT3(Y705) dephosphorylation and TUJ1 expression were abolished by Hpca siRNA while GFAP expression was enhanced ( xref B and xref ), suggesting that Hpca -induced dephosphorylation of p-STAT3(Y705) is crucial for the promotion of neuronal differentiation."
28017654
CACNA1A activates STAT3.
| 1
CACNA1A activates STAT3. 1 / 1
| 1
sparser
"Blocking of STAT3(Y705) Activation by HPCA Increases Neuronal Differentiation and Decreases Astrocytic Differentiation of NSCs."
28017654
CACNA1A affects SNAP receptor activity
| 3
SNAP receptor activity binds CACNA1A. 3 / 3
| 3
sparser
"Other studies have shown that the SNARE complexes also associate with P/Q type Ca 2+ channels in conjunction with synaptotagmin [88] ."
9223620
sparser
"One mechanism by which they act is through direct interaction of the Gβγ subunit with members of the SNARE complex downstream of voltage-dependent calcium channels, and specifically with the C-terminus of SNAP25 and the H3 domain of syntaxin1A(1-3)."
22368765
sparser
"One mechanism by which they act is through direct interaction of the Gβγ subunit with members of the SNARE complex downstream of voltage-dependent calcium channels, and specifically with the C-terminus of SNAP25 and the H3 domain of syntaxin1A xref - xref ."
22368765
CACNA1A affects RSD-4
3 |
CACNA1A binds RSD-4. 3 / 3
3 |
biogrid
No evidence text available
28167673
biogrid
No evidence text available
28167673
biogrid
No evidence text available
28167673
CACNA1A affects Migraine with Aura
| 1 1 2
CACNA1A activates Migraine with Aura.
| 1 2
CACNA1A activates Migraine with Aura. 2 / 2
| 1 2
reach
"Familial Hemiplegic Migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in the CACNA1A gene."
| PMC
reach
"Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the alpha 1A subunit of voltage gated Ca V 2.1 calcium channels."
27032388
CACNA1A binds Migraine with Aura. 1 / 1
| 1
sparser
"Mutations in the CACNA1A gene in humans have been associated with familial hemiplegic migraine with aura (FHM) ( xref ) ( xref ), episodic ataxia type 2 (EA2) ( xref ) ( xref ) ( xref ), spinocerebellar ataxia type 6 (SCA6) ( xref ) ( xref ) ( xref ) ( xref ) and epilepsy ( xref ) ( xref )."
18597946
CACNA1A affects MSC
| 3
CACNA1A inhibits MSC. 3 / 3
| 3
sparser
"The movement of gating charges is of crucial importance for understanding the mechanism of voltage-dependent inactivation of MscS."
28101504
sparser
"In the present study, we investigated the role of arginine residues in TM1 and TM2 in the voltage-dependent inactivation of MscS."
28101504
sparser
"In conclusion, we have shown that the neutralization of the arginine residues in TM1 and TM2 does not influence the stretch activation and voltage-dependent inactivation of MscS."
28101504
CACNA1A affects Kv1
| 3
CACNA1A activates Kv1.
| 2
CACNA1A activates Kv1. 2 / 2
| 2
sparser
"xref and xref show that, compared to its WT counterpart, the steady-state activation curve of the Kv1.4-Kv1.1 I262T heterotetramer shows a depolarizing shift of about 10 mV, indicating that the EA1 mutant is capable of modifying the voltage-dependent activation of Kv1.4."
26778656
sparser
"For example, it is unknown whether I262T affects voltage-dependent activation and inactivation of Kv1.1."
26778656
CACNA1A inhibits Kv1.
| 1
CACNA1A inhibits Kv1. 1 / 1
| 1
sparser
"For example, it is unknown whether I262T affects voltage-dependent activation and inactivation of Kv1.1."
26778656
CACNA1A affects IL2
| 1 2
CACNA1A activates IL2.
| 2
CACNA1A activates IL2. 2 / 2
| 2
reach
"With B/I stimulation and culture in 20 units m1-1 IL-2 expanded cells become predomi- nantly CD8+ T-cells with some CD4helper cells."
8305969
reach
"REFERENCES Agrewala J. N., Vinay D. S., Joshi A. and Mishra G. C. (1994) A 150 kDa molecule of macrophage membrane stimulates interleukin-2 and interferon-gamma production and proliferation of ovalbumin specific CD4+ T cells."
8604218
CACNA1A binds IL2.
| 1
CACNA1A binds IL2. 1 / 1
| 1
sparser
"In the present study, we examined the interaction between recombinant human interleukin-2 (rhIL-2) and the voltage-dependent calcium (Ca2+) current using the whole-cell patch-clamp technique."
8390310
CACNA1A affects IFNG
| 3
CACNA1A activates IFNG. 3 / 3
| 3
reach
"In fact, we found that B/I activated T cells grown in IL-7/15 had increased IFN-gamma responses compared to cells grown in IL-2."
19198835
reach
"REFERENCES Agrewala J. N., Vinay D. S., Joshi A. and Mishra G. C. (1994) A 150 kDa molecule of macrophage membrane stimulates interleukin-2 and interferon-gamma production and proliferation of ovalbumin specific CD4+ T cells."
8604218
reach
"B/I activated tDLN release IFN-gamma in response to tumor challenge."
21050466
CACNA1A affects GRIA
| 3
CACNA1A binds GRIA.
| 2
GRIA binds CACNA1A. 2 / 2
| 2
sparser
"PAs are positively-charged molecules which bind to Ca++-permeable AMPAR in a voltage-dependent manner, resulting in inward rectification and a reduction in synaptic currents even at the resting membrane potential of the cell xref ."
20153060
sparser
"These data may suggest that high concentrations of cyclothiazide cause a complex interactions between AMPA receptors and voltage-dependent Ca z+ channels."
8575524
CACNA1A inhibits GRIA.
| 1
CACNA1A inhibits GRIA. 1 / 1
| 1
sparser
"Voltage-dependent inhibition of AMPAR again suggests that PhTX-343 analogues are acting as open channel blockers."
12559123
CACNA1A affects GNB1, and GNG2
3 |
CACNA1A binds GNB1 and GNG2. 3 / 3
3 |
hprd
No evidence text available
9238069
hprd
No evidence text available
9009193
hprd
No evidence text available
12527722
CACNA1A affects FHM3
| 3
CACNA1A activates FHM3. 2 / 2
| 2
reach
"FHM is a genetically heterogeneous disease, in which mutations can occur in the ion transportation genes CACNA1A, ATP1A2, and SCN1A, promoting the different types of familial migraines, FHM1, FHM2 and FHM3."
27313535
reach
"FHM1, FHM2 and FHM3 are caused by mutations in the ion-channel genes CACNA1A, ATP1A2 and SCN1A, respectively [XREF_BIBR - XREF_BIBR]."
18846413
Mutated CACNA1A activates FHM3. 1 / 1
| 1
reach
"FHM is classified into 3 types : FHM1, which is caused by CACNA1A mutations on chromosome 19p13, FHM2, caused by ATP1A2 mutations on chromosome 1q21-23, and FHM3, caused by SCN1A mutations on chromosome 2q24 [XREF_BIBR, XREF_BIBR]."
25969684
CACNA1A affects FHM2
| 3
CACNA1A activates FHM2. 2 / 2
| 2
reach
"FHM1, FHM2 and FHM3 are caused by mutations in the ion-channel genes CACNA1A, ATP1A2 and SCN1A, respectively [XREF_BIBR - XREF_BIBR]."
18846413
reach
"FHM is a genetically heterogeneous disease, in which mutations can occur in the ion transportation genes CACNA1A, ATP1A2, and SCN1A, promoting the different types of familial migraines, FHM1, FHM2 and FHM3."
27313535
Mutated CACNA1A activates FHM2. 1 / 1
| 1
reach
"FHM is classified into 3 types : FHM1, which is caused by CACNA1A mutations on chromosome 19p13, FHM2, caused by ATP1A2 mutations on chromosome 1q21-23, and FHM3, caused by SCN1A mutations on chromosome 2q24 [XREF_BIBR, XREF_BIBR]."
25969684
CACNA1A affects FHM type 1
| 3
CACNA1A activates FHM type 1. 3 / 3
| 3
reach
"FHM type 1 (FHM1) is caused by mutations in the CACNA1A gene, encoding the pore forming subunit of Ca V 2.1 channels that conduct P/Q-type Ca 2+ current (XREF_FIG;)."
19005038
reach
"FHM type 1 (FHM1) is caused by missense mutations in the CACNA1A gene (e.g., R192Q, S218L) encoding the pore forming alpha 1A subunit of neuronal voltage gated Ca V 2.1 channels."
21490217
reach
"FHM type 1 (FHM1) is caused by mutations in the CACNA1A gene, which encodes the pore forming alpha 1A subunit of neuronal Ca V 2.1 voltage gated Ca 2+ channels 9."
22144569
CACNA1A affects CAV2
| 3
CACNA1A inhibits CAV2.
| 2
CACNA1A inhibits CAV2. 2 / 2
| 2
sparser
"We highlight that intracellular calcium concentration reflects the voltage-dependent activation and inactivation of CaV which in turn affects the behavior of KCNL current."
31260485
sparser
"This latter difference reflects a slowing of channel gating and is characteristic of the voltage-dependent inhibition of Cav2 channels via G protein βγ subunits [ xref – xref ]."
27172914
CACNA1A activates CAV2.
| 1
CACNA1A activates CAV2. 1 / 1
| 1
sparser
"We highlight that intracellular calcium concentration reflects the voltage-dependent activation and inactivation of CaV which in turn affects the behavior of KCNL current."
31260485
CACNA1A affects 4T1
| 3
CACNA1A activates 4T1. 3 / 3
| 3
reach
"To confirm our hypothesis that host T cells play little or no role in tumor regression after adoptive transfer, athymic nude mice with 4 day 4T1 tumors were treated with CYP alone or CYP + B/I activated 4T1 draining lymphocytes, with or without exogenous IL-2 (7500 U i.p. on days 0 - 3 after AIT)."
21050466
reach
"Host Balb/C mice with 4T1 tumors were untreated, treated with CYP on day 9, or treated with CYP followed on day 10 by adoptive transfer of B/I activated 4T1 DLN cells."
21050466
reach
"BALB/c mice were either untreated, vaccinated with irradiated 4T1, treated with CYP alone, or treated with CYP + AIT with B/I activated 4T1 tDLN lymphocytes."
21050466
ADRB1 affects ADRB2, AGT, CACNA1A, CACNA1C, and SLC12A3
| 3
SLC12A3 binds CACNA1A, CACNA1C, ADRB1, ADRB2, and AGT. 3 / 3
| 3
sparser
"We find nominal evidence of association of ADRB1 , ADRB2 , AGT , CACNA1A , CACNA1C , and SLC12A3 polymorphisms with one or more BP traits in the CHARGE GWA meta-analysis."
21444836
sparser
"Nominal evidence of association of ADRB1, ADRB2, AGT, CACNA1A, CACNA1C , and SLC12A3 polymorphisms with one or more BP traits was observed."
21953487
sparser
"We find nominal evidence of association of ADRB1, ADRB2, AGT, CACNA1A, CACNA1C, and SLC12A3 polymorphisms with 1 or more BP traits in the Cohorts for Heart and Aging Research in Genomic Epidemiology genome-wide association meta-analysis."
21444836
Tid affects CACNA1A
| 2
CACNA1A binds tid. 2 / 2
| 2
sparser
"In the studies reported here performed in the absence of BgTx, we can not distinguish whether lidocaine and procaine reduced ['zsI]TID incorporation by binding to the agonist binding site and inducing desensitization, or by directly competing with ['zsI]TID binding to the NCB site."
7511416
sparser
"Finally, TID inhibited phencyclidine and HTX binding in the presence of 100 AM carbamylcholine, conditions under which no TID binding to the NCB site would be predicted, on the basis ['zsI]TID photolabeling experi ments [12]."
7511416
Tetraethylammonium affects CACNA1A
| 2
Tetraethylammonium inhibits CACNA1A. 2 / 2
| 2
sparser
"Hence, to evaluate the activity of this factor we used increased extracellular K and tetraethylammonium as non-specific blockers of K channels, because tetraethylammonium inhibits voltage-dependent, Ca-activated and ATP-dependent K channels ."
12191587
sparser
"Similarly, Adams et al. (1999) recently reported that a mutation in the pore-loop complex of a Na + channel altered Na + selectivity and revealed a voltage-dependent inhibition by extracellularly applied tetraethylammonium (TEA)."
11159438
Neurotoxin affects CACNA1A
| 2
CACNA1A binds neurotoxin. 2 / 2
| 2
sparser
"ACO has long been known as a neurotoxin that selectively interacts with the voltage-dependent neuronal Na + channels by binding to its neurotoxin binding site 2 at the pore region of the alpha subunit, rendering a prolonged opening of the Na + channel [ xref ]."
28056022
sparser
"Saxitoxin (STX) is a water-soluble neurotoxin that binds to the voltage-dependent sodium channels in excitatory cells."
23402841
MiR-711 affects CACNA1A
| 2
MiR-711 inhibits CACNA1A.
| 1
MiR-711 inhibits CACNA1A. 1 / 1
| 1
reach
"Dual-luciferase assays revealed that miR-711, miR-3191-5p, and miR-4786-3p down-regulated CACNA1A IRES driven luciferase activities compared to a negative control miRNA (XREF_FIG)."
27412786
MiR-711 decreases the amount of CACNA1A.
| 1
MiR-711 decreases the amount of CACNA1A. 1 / 1
| 1
reach
"qRT-PCR studies of total RNA showed that miR-711 and miR-4786-3p decreased CACNA1A mRNA expression relative to a negative control miRNA, but miR-3191-5p did not affect either CACNA1A-Q11 or CACNA1A-Q33 mRNA expression (XREF_FIG)."
27412786
Magnesium(2+) affects CACNA1A
| 2
Magnesium(2+) inhibits CACNA1A. 1 / 1
| 1
sparser
"They are also highly permeable to Ca2+, and exhibit voltage-dependent inhibition by Mg2+."
11823786
Magnesium(2+) inhibits CACNA1A. 1 / 1
| 1
sparser
"However, voltage-dependent magnesium inhibition is significantly reduced in all variants."
31429998
Hsa-miR-7974 affects CACNA1A
2 |
Transcriptionally active hsa-miR-7974 decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-767-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-767-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-7113-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-7113-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-7106-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-7106-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6866-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-6866-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6842-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-6842-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-6836-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-6836-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6829-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-6829-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-6828-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-6828-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-6791-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-6791-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6780b-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-6780b-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-6778-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-6778-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-6752-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-6752-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-6747-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-6747-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-647 affects CACNA1A
2 |
Transcriptionally active hsa-miR-647 decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-644a affects CACNA1A
2 |
Transcriptionally active hsa-miR-644a decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-632 affects CACNA1A
2 |
Transcriptionally active hsa-miR-632 decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-623 affects CACNA1A
2 |
Transcriptionally active hsa-miR-623 decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-605-5p affects CACNA1A
2 |
Transcriptionally active hsa-miR-605-5p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-532-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-532-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-5087 affects CACNA1A
2 |
Transcriptionally active hsa-miR-5087 decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-4780 affects CACNA1A
2 |
Transcriptionally active hsa-miR-4780 decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-4762-5p affects CACNA1A
2 |
Transcriptionally active hsa-miR-4762-5p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-4687-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-4687-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-4288 affects CACNA1A
2 |
Transcriptionally active hsa-miR-4288 decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-3911 affects CACNA1A
2 |
Transcriptionally active hsa-miR-3911 decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-346 affects CACNA1A
2 |
Transcriptionally active hsa-miR-346 decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-335-3p affects CACNA1A
2 |
Transcriptionally active hsa-miR-335-3p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
23824327
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-212-5p affects CACNA1A
2 |
Transcriptionally active hsa-miR-212-5p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-203a-5p affects CACNA1A
2 |
Transcriptionally active hsa-miR-203a-5p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Hsa-miR-188-5p affects CACNA1A
2 |
Transcriptionally active hsa-miR-188-5p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-147a affects CACNA1A
2 |
Transcriptionally active hsa-miR-147a decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-1273g-5p affects CACNA1A
2 |
Transcriptionally active hsa-miR-1273g-5p decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
28735896
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-1231 affects CACNA1A
2 |
Transcriptionally active hsa-miR-1231 decreases the amount of CACNA1A. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
28735896
Cre affects CACNA1A
| 2
Cre inhibits CACNA1A.
| 1
Cre inhibits CACNA1A. 1 / 1
| 1
reach
"The specificity of the NEX and Cre mediated Cacna1a gene deletion was assessed by immunohistochemistry (XREF_FIG) and by Western blot analysis (XREF_SUPPLEMENTARY)."
24205277
Cre activates CACNA1A.
| 1
Cre activates CACNA1A. 1 / 1
| 1
reach
"Although both the L7-Cre and Math1-Cre lines produce robust Cre recombinase activity in PCs and GCs, respectively and several studies, including our own, have illustrated motor behavioral effects of Cre mediated recombination of floxed Cacna1a in PCs and GCs, it is possible that recombination was inadequate."
25109669
Cation affects CACNA1A
| 2
Cation inhibits CACNA1A. 2 / 2
| 2
sparser
"Menestrina G: Ionic channels formed by Staphylococcus aureus alpha- toxin: voltage-dependent inhibition by divalent and trivalent cations../Membr Bio/1986, 90:177-190."
9266180
sparser
"Ionic channels formed by Staphylococcus aureus a-toxin: voltage-dependent inhibition by divalent and trivalent cations."
7545444
Capacity produced 6-log spore biological indicators affects CACNA1A
| 2
Capacity produced 6-log spore biological indicators activates CACNA1A. 2 / 2
| 2
eidos
"aHP systems achieve a ~ 4-log reduction on C. difficile spores in vitro [ 80 ] and have limited capacity to inactivate commercially produced 6-log spore biological indicators ( BIs ) [ 81 , 83 ] ."
| PMC
eidos
"One aHP system ( ASP Glosair ) achieves a ~ 4-log reduction on C. diffi cile spores in vitro ) and has limited capacity to inactivate commercially produced 6-log spore biological indicators ( BIs ) ( Andersen et al ., 2006 ; Holmdahl et al ., 2011 ) ."
| PMC
Anion affects CACNA1A
| 2
Anion inhibits CACNA1A.
| 1
Anion inhibits CACNA1A. 1 / 1
| 1
sparser
"CFTR channel currents are known to be subject to voltage-dependent inhibition by unknown anions present in the cytosol ( xref ; xref ; xref ; xref ; xref )."
20142516
Anion binds CACNA1A.
| 1
Anion binds CACNA1A. 1 / 1
| 1
sparser
"GRP78 was shown to interact with JEV E protein by coimmunoprecipitation, and was additionally shown to interact with voltage dependent anion protein (VDAC) through the same methodology."
25126612
YLPM1 affects CACNA1A
2 |
CACNA1A binds YLPM1. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
VDAC1 affects CACNA1A
| 2
VDAC1 binds CACNA1A. 2 / 2
| 2
sparser
"VDAC forms a large voltage dependent pore with maximum conductance of 4–5 nS in symmetrical 1 M KCl ( xref ; xref ; xref )."
27783269
sparser
"In a lipid bilayer, recombinant VDAC can form stable open states and feature voltage-dependent transitions ( xref )."
18755977
TUBB2B affects CACNA1A
2 |
CACNA1A binds TUBB2B. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
TSPOAP1 affects CACNA1A
2 |
CACNA1A binds TSPOAP1. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
SYT1 affects CACNA1A
1 1 |
SYT1 binds CACNA1A. 2 / 2
1 1 |
biogrid
No evidence text available
9303303
hprd
No evidence text available
9303303
SNAP25 affects CACNA1A
| 2
SNAP25 binds CACNA1A. 1 / 1
| 1
sparser
"No conclusions could be reached as to the association of SNAP-25 with the N-type calcium channel."
7890025
Voltage_gated_ion_channels binds SNAP25 and CACNA1A. 1 / 1
| 1
sparser
"Previous studies have shown that SNAP-25 is associated with N and P/Q type voltage gated calcium channels [for review, see ref. [ xref ]], and specifically impedes calcium currents through P/Q type channels activated in response to action potential-like stimuli [ xref ]."
18959796
RIMBP2 affects CACNA1A
1 | 1
CACNA1A binds RIMBP2. 2 / 2
1 | 1
sparser
"Interactions of Cav2.1 with Cavβ4 and Rimbp2 were significantly reduced while those with GABAB2 were enhanced in the cerebellum of Cacna1aCtmKO/CtmKO mice."
28510727
biogrid
No evidence text available
21078624
RBM12B affects CACNA1A
2 |
CACNA1A binds RBM12B. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
PyBroP affects CACNA1A
| 2
PyBroP activates CACNA1A. 2 / 2
| 2
reach
"As in the synthesis of WN-2 and WN-4, Fragments A-II and B-I were treated with PyBroP in the presence of Hunig 's base and DMAP to form ester 13."
27676096
reach
"Fragments A-I and B-I were treated with PyBroP in the presence of Hunig 's base and DMAP to form ester 8 in 85% yield."
27676096
Phe-Val affects CACNA1A
| 2
Phe-Val inhibits CACNA1A. 2 / 2
| 2
sparser
"The voltage-dependent Fv inhibition allows us to quantify indirectly the VSD movement in membranes containing a fraction of nonphospholipids (lipids without phosphodiesters; xref ( xref ) and xref ( xref ) as examples, xref )."
21427721
sparser
"The voltage-dependent Fv inhibition closely reflects the voltage dependence of the VSD movement."
21427721
PUF60 affects CACNA1A
2 |
CACNA1A binds PUF60. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
PTH affects CACNA1A
| 2
PTH activates CACNA1A. 2 / 2
| 2
sparser
"Parathyroid hormone activates voltage-dependent and receptor operated calcium channels on kidney cells and could stimulate uptake of Pb in kidney ( Friedman and Gesek, 1995 )."
10874157
sparser
"Ua might inhibit a calcium channel activated by ET-1 and PTH, in addition to blocking PLC."
7803518
PKC affects CACNA1A
| 2
PKC binds CACNA1A. 2 / 2
| 2
sparser
"The inhibitory effect of echinacoside on evoked glutamate release was associated with reduced voltage-dependent Ca 2+ entry and subsequent suppression of protein kinase C activity [ xref ]."
29344414
sparser
"According to these results, we suggest that the inhibitory effect of echinacoside on evoked glutamate release is associated with reduced voltage-dependent Ca 2+ entry and subsequent suppression of protein kinase C activity."
27347934
PC affects CACNA1A
| 1 1
PC binds CACNA1A.
| 1
CACNA1A binds PC. 1 / 1
| 1
sparser
"Autocatalytic attachment of PCB to apo-SLA occurred ( xref ), which is similar to the reports that autocatalytic binding of PCB to ApcA may occur. xref This antocatalytic reaction was slow and incomplete and lyase was necessary for efficient attachment of PCB to SLA."
28448741
PC activates CACNA1A.
| 1
PC activates CACNA1A. 1 / 1
| 1
reach
"In order to evaluate the effects of delayed Cacna1A ablation on PC signaling and cerebellar cortical outflow in Cacna1a purk (-/-) mice, we analyzed somatic P/Q-type channel currents, PC excitability, concentrating on spontaneous impulse activity, and synaptic transmitter release."
21411672
NOG affects CACNA1A
2 |
NOG increases the amount of CACNA1A.
1 |
Transcriptionally active NOG increases the amount of CACNA1A. 1 / 1
1 |
biopax:ctd
No evidence text available
27188386
NOG decreases the amount of CACNA1A.
1 |
Transcriptionally active NOG decreases the amount of CACNA1A. 1 / 1
1 |
biopax:ctd
No evidence text available
27188386
Migraine with Aura affects CACNA1A
| 1 1
CACNA1A binds Migraine with Aura. 1 / 1
| 1
sparser
"Mutations in the CACNA1A gene in humans have been associated with familial hemiplegic migraine with aura (FHM) ( xref ) ( xref ), episodic ataxia type 2 (EA2) ( xref ) ( xref ) ( xref ), spinocerebellar ataxia type 6 (SCA6) ( xref ) ( xref ) ( xref ) ( xref ) and epilepsy ( xref ) ( xref )."
18597946
Migraine with Aura activates CACNA1A.
| 1
Migraine with Aura activates CACNA1A. 1 / 1
| 1
reach
"Familial hemiplegic migraine type 1 (FHM1) is a form of migraine with aura caused by heterozygous mutations in 4 genes : CACNA1A, ATP1A2, SNC1A and PRRT2, but further heterogeneity is expected."
30167989
MPEG1 affects CACNA1A
| 2
CACNA1A binds MPEG1. 2 / 2
| 2
sparser
"This new understanding of the mechanism of MPG1 assembly and of interactions between MPG1, MHP1 and Cut2 may lead to identification of targets for disruption of rice blast infection."
27142249
sparser
"A further understanding of the molecular mechanism by which MPG1 and MHP1 assemble into the amphipathic layers and how Cut2 is activated will facilitate development of inhibitory strategies against rice blast infection."
27142249
MFSD11 affects CACNA1A
| 1 1
MFSD11 inhibits CACNA1A. 2 / 2
| 1 1
sparser
"BIOCHIMICA ET BIOPHYSICA ACTA 791 BBA 66539 INACTIVATION OF SERINE TRANSHYDROXYMETHYLASE AND THREONINE ALDOLASE ACTIVITIES bI."
5017703
reach
"BIOCHIMICA ET BIOPHYSICA ACTA 791 BBA 66539 INACTIVATION OF SERINE TRANSHYDROXYMETHYLASE AND THREONINE ALDOLASE ACTIVITIES bI."
5017703
LOXL1 affects CACNA1A
| 2
CACNA1A binds LOXL1. 2 / 2
| 2
sparser
"Variants in two genes, LOXL1 and CACNA1A have been previously associated with XFS."
28553957
sparser
"We failed to detect any evidence of statistically significant interaction between CACNA1A rs4926244 and the sentinel LOXL1 polymorphisms, suggesting that both loci impact XFS risk via distinct biological pathways."
25706626
LAMB1 affects CACNA1A
2 |
CACNA1A binds LAMB1. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
Kv1 affects CACNA1A
| 2
Kv1 inhibits CACNA1A.
| 1
Kv1 inhibits CACNA1A. 1 / 1
| 1
sparser
"Although it is still an open question regarding the role of the reciprocal neural network in cerebellum function, it would be worthwhile in the future to test the intriguing hypothesis that the effect of the I262T mutation on voltage-dependent Kv1.1/1.4 activation and inactivation may destabilize intrinsic neuronal excitability and induce network variability in this two-way communication between the two subcortical structures."
26778656
Kv1 activates CACNA1A.
| 1
Kv1 activates CACNA1A. 1 / 1
| 1
sparser
"Although it is still an open question regarding the role of the reciprocal neural network in cerebellum function, it would be worthwhile in the future to test the intriguing hypothesis that the effect of the I262T mutation on voltage-dependent Kv1.1/1.4 activation and inactivation may destabilize intrinsic neuronal excitability and induce network variability in this two-way communication between the two subcortical structures."
26778656
KLHL1 affects CACNA1A
2 |
CACNA1A binds KLHL1. 2 / 2
2 |
biogrid
No evidence text available
17289272
biogrid
No evidence text available
17289272
INS affects CACNA1A
| 2
CACNA1A binds INS. 1 / 1
| 1
sparser
"Hence, we have addressed the question of whether ODN influences glucose or glibenclamide-induced insulin secretion binding to voltage dependent Ca2+ channels."
7544471
CACNA1A binds ERC1 and INS. 1 / 1
| 1
sparser
"ELKS forms a potent insulin secretion complex with L-type voltage-dependent Ca 2+ channels on the vascular-facing plasma membrane of β-cells, enabling polarized Ca 2+ influx and first-phase insulin secretion from islets."
31500835
IK affects CACNA1A
| 2
CACNA1A binds IK. 1 / 1
| 1
sparser
"These findings suggest that MS-551 produces frequency-dependent class III action, presumably due to the voltage-dependent binding and unbinding to the IK channels."
8759253
KCN binds CACNA1A, FOXH1, and IK. 1 / 1
| 1
sparser
"In Drosophila neurons the fast component of I K has been associated with the voltage-dependent potassium channel gene Shal ( Shaker cognate I ) ( xref ) and the voltage-dependent and calcium-activated potassium channel gene slowpoke ( slo ) ( xref )."
18305244
GRIA affects CACNA1A
| 2
GRIA binds CACNA1A. 2 / 2
| 2
sparser
"PAs are positively-charged molecules which bind to Ca++-permeable AMPAR in a voltage-dependent manner, resulting in inward rectification and a reduction in synaptic currents even at the resting membrane potential of the cell xref ."
20153060
sparser
"These data may suggest that high concentrations of cyclothiazide cause a complex interactions between AMPA receptors and voltage-dependent Ca z+ channels."
8575524
GJ affects CACNA1A
| 2
GJ binds CACNA1A. 2 / 2
| 2
sparser
"Connexin hemichannels display two distinct forms of voltage-dependent gating, corresponding to the operation of Vj- or fast gates and loop- or slow gates."
24047988
sparser
"The structure of the pore is critical to understanding the molecular mechanisms underlying selective permeation and voltage-dependent gating of channels formed by the connexin gene family."
19468074
CSNK2B affects CACNA1A
2 |
CACNA1A binds CSNK2B. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CFI affects CACNA1A
| 2
CFI binds CACNA1A.
| 1
CACNA1A binds HCN4 and CFI. 1 / 1
| 1
sparser
"In response to stress-associated β-adrenergic stimulation, cyclic AMP (cAMP) is generated which binds directly to HCN4 and increases I f by shifted voltage-dependent activation."
28573409
CFI activates CACNA1A.
| 1
CFI activates CACNA1A. 1 / 1
| 1
sparser
"Isoprenaline (ISO), a β-adrenoceptor agonist, shifts voltage-dependent I f activation to more positive potentials resulting in an increase of I f , which has been suggested to be the main mechanism underlying the effect of β-adrenergic stimulation."
23060799
CCL2 affects CACNA1A
| 2
CCL2 inhibits CACNA1A. 1 / 1
| 1
sparser
"In addition, MCP-1 inhibited a voltage-dependent, noninactivating outward current, presumably a delayed rectifier type K(+) conductance."
16775210
CCL2 inhibits CACNA1A. 1 / 1
| 1
sparser
"Sun et al showed that CCL2 inhibits a voltage-dependent, non-inactivating outward current, presumably a delayed rectifier type K + conductance, which is known to regulate neuronal excitability ( xref )."
20117131
CC2D2A affects CACNA1A
| 2
CACNA1A binds CC2D2A. 1 / 1
| 1
sparser
"Mutations in the CACNA1A gene are associated with episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6)."
20948794
Calcium_channels binds Myosin_complex, CACNA1A, CC2D2A, and GTF2B. 1 / 1
| 1
sparser
"Ablation of myosin-IIB in mice is embryonic lethal, and myosin-IIB ( MYH10 ) mutations are thought to be embryonic lethal in humans, as well; however, myosin-IIB function has been associated with the pathogenesis of spinocerebellar ataxia type 6 (SCA6) through associations of myosin-IIB and Cav2.1 calcium channel polyglutamate tracts [ xref ]."
20850431
CACNA1A affects tolC
| 2
CACNA1A inhibits tolC.
| 1
CACNA1A inhibits tolC. 1 / 1
| 1
sparser
"Voltage-dependent activation and inactivation of TOC were consistent with an A-type K+ current, I(KA)."
12223577
CACNA1A activates tolC.
| 1
CACNA1A activates tolC. 1 / 1
| 1
sparser
"Voltage-dependent activation and inactivation of TOC were consistent with an A-type K+ current, I(KA)."
12223577
CACNA1A affects tid
| 2
CACNA1A binds tid. 2 / 2
| 2
sparser
"In the studies reported here performed in the absence of BgTx, we can not distinguish whether lidocaine and procaine reduced ['zsI]TID incorporation by binding to the agonist binding site and inducing desensitization, or by directly competing with ['zsI]TID binding to the NCB site."
7511416
sparser
"Finally, TID inhibited phencyclidine and HTX binding in the presence of 100 AM carbamylcholine, conditions under which no TID binding to the NCB site would be predicted, on the basis ['zsI]TID photolabeling experi ments [12]."
7511416
CACNA1A affects serotonin
| 1 1
CACNA1A inhibits serotonin. 1 / 1
| 1
reach
"The evolutionary and functional relationship between the UNC-2 channel and the migraine associated CACNA1A channel was further confirmed through experiments showing that transgenic expression of human CACNA1A can suppress the lethargic and serotonin deficient phenotypes of unc-2 mutant animals."
16927961
CACNA1A inhibits serotonin. 1 / 1
| 1
sparser
"Three drugs have been approved by the FDA for the treatment of pain in FM: pregabalin, which binds to a voltage-dependent, presynaptic calcium channel, and duloxetine and milnacipran, which selectively inhibit reuptake of serotonin and norepinephrine, respectively."
26175876
CACNA1A affects rEag1
| 2
CACNA1A inhibits rEag1. 2 / 2
| 2
sparser
"We therefore propose that via its direct interaction with the C-linker/CNBHD, the rEag1 eag domain, but not the hERG1 counterpart, may destabilize or mask an inherent voltage-dependent inactivation of rEag1 channels."
25333352
sparser
"We therefore propose that the eag domain may block the inherent voltage-dependent inactivation of rEag1 channels by directly/indirectly modulating certain gating conformations, such as those involving the S4–S5 linker."
25333352
CACNA1A affects neurotoxin
| 2
CACNA1A binds neurotoxin. 2 / 2
| 2
sparser
"ACO has long been known as a neurotoxin that selectively interacts with the voltage-dependent neuronal Na + channels by binding to its neurotoxin binding site 2 at the pore region of the alpha subunit, rendering a prolonged opening of the Na + channel [ xref ]."
28056022
sparser
"Saxitoxin (STX) is a water-soluble neurotoxin that binds to the voltage-dependent sodium channels in excitatory cells."
23402841
CACNA1A affects nat
| 2
CACNA1A inhibits nat.
| 1
CACNA1A inhibits nat. 1 / 1
| 1
sparser
"We also analysed voltage-dependent activation and inactivation of I Nat for each of the three cocktails tested."
22623672
CACNA1A activates nat.
| 1
CACNA1A activates nat. 1 / 1
| 1
sparser
"We also analysed voltage-dependent activation and inactivation of I Nat for each of the three cocktails tested."
22623672
CACNA1A affects lithium(1+)
| 2
CACNA1A activates lithium(1+). 2 / 2
| 2
reach
"CACNA1A knockdown had no effect on period at baseline, but blocked the ability of lithium to lengthen period."
26476274
reach
"CACNA1A knockdown had no effect on period at baseline, but blocked the ability of lithium to lengthen period (XREF_FIG)."
26476274
CACNA1A affects increase
| 2
CACNA1A inhibits increase. 2 / 2
| 2
sparser
"This increase was partially inhibited by the calcium channel inhibitor (verapamil), the PI3k inhibitor (wortmannin), and the PLC inhibitor (U-73122)."
9491384
sparser
"The nicotine-induced increase in DBI mRNA expression was inhibited by L-type voltage-dependent Ca(2+) channel (VDCC) inhibitors such as verapamil, calmodulin antagonist (W-7), and Ca(2+)/calmodulin-dependent protein kinase II (CAM II kinase) inhibitor (KN-62), whereas P/Q- and N-type VDCC inhibitors showed no effects."
11038246
CACNA1A affects homovanillic acid
| 2
CACNA1A inhibits homovanillic acid.
| 1
CACNA1A inhibits homovanillic acid. 1 / 1
| 1
sparser
"How does Ca v β regulate voltage-dependent activation and inactivation of HVA channels?."
22981275
CACNA1A activates homovanillic acid.
| 1
CACNA1A activates homovanillic acid. 1 / 1
| 1
sparser
"How does Ca v β regulate voltage-dependent activation and inactivation of HVA channels?."
22981275
CACNA1A affects glucose
| 2
CACNA1A activates glucose. 2 / 2
| 2
reach
"BI-78D3 increased glucose uptake about 90% (1.97 +/- 0.11) and Acebutolol increase glucose uptake about 50% (1.48 +/- 0.17) comparing with control respectively."
29129046
reach
"BI-78D3 increased glucose uptake about 50% (1.54 +/- 0.16) and Acebutolol increase glucose uptake about 45% (1.46 +/- 0.02) comparing with control respectively."
29129046
CACNA1A affects gK
| 2
CACNA1A activates gK. 2 / 2
| 2
sparser
"Therefore, given the voltage-dependent activation of gK during repolarization [34] and the timedependent inactivation during diastole [39], it is entirely possible that the magnitude of the outward K+ current might increase progressively during a series of action potentials, moving the maximum diastolic potential closer to EK."
4816658
sparser
"Therefore, given the voltage-dependent activation of gK during repolarization [34] and the timedependent inactivation during diastole [39], it is entirely possible that the magnitude of the outward K+ current might increase progressively during a series of action potentials, moving the maximum diastolic potential closer to EK."
4816658
CACNA1A affects expression
| 2
CACNA1A inhibits expression. 2 / 2
| 2
sparser
"MHP1 did not inhibit the expression of IL-6 in cultured medium (21.8 ± 7.7 pg/ml in control; 99.1 ± 4.7 pg/ml in S100β-treated cells; 135.1 ± 25.3 pg/ml in MHP1 and S100β-treated cells, N = 3 in each group), which indicated that the effects of MHP-1 were not nonspecific."
27897273
sparser
"Although MHP1 significantly inhibited LPS-induced IL-6 and TNF-α expression in cells treated with the negative control siRNA ( xref ), the expression levels of IL-6 and TNF-α were not changed in the RANK-siRNA-treated cells ( xref )."
27897273
CACNA1A affects dihydropyridine
| 2
Dihydropyridine binds CACNA1A. 1 / 1
| 1
sparser
"These data suggest that dihydropyridine calcium channel antagonists and activators bind to different allosterically linked receptors or domains of the dihydropyridine protein associated with the voltage-dependent calcium channels."
7530159
CACNA1A activates dihydropyridine.
| 1
CACNA1A activates dihydropyridine. 1 / 1
| 1
sparser
"It was shown 30 years ago that dihydropyridine voltage-dependent calcium channel blockers decreased MR activation by blunting the release of intracellular calcium that activates aldosterone synthesis by adrenal zona glomerulosa cells xref – xref ."
26466326
CACNA1A affects cytokine
| 2
CACNA1A inhibits cytokine.
| 1
CACNA1A inhibits cytokine. 1 / 1
| 1
sparser
"These results indicated that MHP1 inhibited the LPS-induced inflammatory cytokines through RANK-induced signals."
27897273
CACNA1A binds cytokine.
| 1
CACNA1A binds cytokine. 1 / 1
| 1
sparser
"APCA may also be associated with cytokines, which may enhance embryonic and trophoblast development."
1285902
CACNA1A affects cell death
| 2
CACNA1A activates cell death. 2 / 2
| 2
reach
"Abrogation of Ca V 2.1 channel function in Cacna1a knockout mice causes profound cerebellar cell death."
25109669
reach
"Why the BI strain was able to induce epithelial destruction and death in our monoassociated mice, as opposed to Chen and colleagues ' conventional mice is unknown, but possibilities include the greater number of organisms used to colonize our mice (1x10 8 CFU 's vs. 1x10 5 CFU 's), age related differences in the host immune response, less developed mucosal responses in germ-free mice, or an influence by the retained host micro-biota after antibiotics."
20977342
CACNA1A affects cation
| 2
CACNA1A activates cation. 2 / 2
| 2
sparser
"This voltage-dependent activation of HCN channels is furthermore modulated by cyclic nucleotides."
28074902
sparser
"MAChRs shifted voltage-dependent activation of the hyperpolarization-activated cation current to more positive levels."
22858620
CACNA1A affects alpha1ACT
| 2
CACNA1A activates alpha1ACT. 2 / 2
| 2
reach
"Because both eIF4AII and eIF4GII affected not only CACNA1A IRES driven translation of alpha1ACT but also cap dependent translation of full-length alpha1A (XREF_FIG), we used IRES-alpha1ACT vectors (XREF_SUPPLEMENTARY) to test the binding affinities of eIF4AII and eIF4GII to CACNA1A IRES."
27412786
reach
"We identified miR-3191-5p as a microRNA (miRNA) that targeted CACNA1A IRES and preferentially inhibited the CACNA1A IRES driven translation of alpha1ACT in an Argonaute 4 (Ago4)-dependent manner."
27412786
CACNA1A affects aceA
| 2
CACNA1A inhibits aceA. 1 / 1
| 1
sparser
"Patch-clamp experiments demonstrated that these compounds shift the voltage-dependent inactivation of ICl(vol) channels toward more negative values."
9252442
CACNA1A inhibits aceA. 1 / 1
| 1
sparser
"Patch-clamp experiments demonstrated that these compounds shift the voltage-dependent inactivation of ICl(vol) channels toward more negative values."
9252442
CACNA1A affects YLPM1
2 |
CACNA1A binds YLPM1. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CACNA1A affects VDAC1
| 2
VDAC1 binds CACNA1A. 2 / 2
| 2
sparser
"VDAC forms a large voltage dependent pore with maximum conductance of 4–5 nS in symmetrical 1 M KCl ( xref ; xref ; xref )."
27783269
sparser
"In a lipid bilayer, recombinant VDAC can form stable open states and feature voltage-dependent transitions ( xref )."
18755977
CACNA1A affects TUBB2B
2 |
CACNA1A binds TUBB2B. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CACNA1A affects TSPOAP1
2 |
CACNA1A binds TSPOAP1. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CACNA1A affects SYT1
1 1 |
SYT1 binds CACNA1A. 2 / 2
1 1 |
biogrid
No evidence text available
9303303
hprd
No evidence text available
9303303
CACNA1A affects SNAP25
| 2
SNAP25 binds CACNA1A. 1 / 1
| 1
sparser
"No conclusions could be reached as to the association of SNAP-25 with the N-type calcium channel."
7890025
Voltage_gated_ion_channels binds SNAP25 and CACNA1A. 1 / 1
| 1
sparser
"Previous studies have shown that SNAP-25 is associated with N and P/Q type voltage gated calcium channels [for review, see ref. [ xref ]], and specifically impedes calcium currents through P/Q type channels activated in response to action potential-like stimuli [ xref ]."
18959796
CACNA1A affects SLC26A5
| 2
CACNA1A binds SLC26A5.
| 1
Trypsin binds CACNA1A and SLC26A5. 1 / 1
| 1
sparser
"Because GFP alone did not bring about a voltage-dependent component in the membrane capacitance with or without intracellular trypsin treatment, the voltage-dependent component was associated with prestin."
14747354
CACNA1A activates SLC26A5.
| 1
CACNA1A activates SLC26A5. 1 / 1
| 1
sparser
"Non-linear capacitance measurements were used to infer the characteristics of the gating charge movements ( xref , xref ) thought to be dominated by the voltage-dependent activation of prestin ( xref ; xref )."
20525072
CACNA1A affects RIMBP2
1 | 1
CACNA1A binds RIMBP2. 2 / 2
1 | 1
sparser
"Interactions of Cav2.1 with Cavβ4 and Rimbp2 were significantly reduced while those with GABAB2 were enhanced in the cerebellum of Cacna1aCtmKO/CtmKO mice."
28510727
biogrid
No evidence text available
21078624
CACNA1A affects RHBDF2
| 2
CACNA1A inhibits RHBDF2.
| 1
CACNA1A inhibits RHBDF2. 1 / 1
| 1
sparser
"Voltage-dependent activation and inactivation of TOC were consistent with an A-type K+ current, I(KA)."
12223577
CACNA1A activates RHBDF2.
| 1
CACNA1A activates RHBDF2. 1 / 1
| 1
sparser
"Voltage-dependent activation and inactivation of TOC were consistent with an A-type K+ current, I(KA)."
12223577
CACNA1A affects RBM12B
2 |
CACNA1A binds RBM12B. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CACNA1A affects RANGAP1
| 2
Mutated CACNA1A inhibits RANGAP1. 1 / 1
| 1
reach
"Mice bearing the S218L Cacna1a mutation show low SD threshold, seizures, and premature death, whereas a loss-of-function Cacna1a mutation raises SD threshold and prolongs survival in Kv1.1 KO mutants."
25855492
CACNA1A inhibits RANGAP1. 1 / 1
| 1
reach
"A gain-of-function mutation, S218L, in CACNA1A (FHM1) encoding P/Q-type calcium channels lowers SD threshold, and 20% of FHM patients carrying this mutation develop seizures during attacks."
25855492
CACNA1A affects QDPR
| 2
CACNA1A activates QDPR. 2 / 2
| 2
sparser
"The results indicated that charge neutralization or deletion severely depressed the magnitude of RyR1-mediated Ca(2+) transients coupled to voltage-dependent activation of the DHPR."
16357209
sparser
"The attenuated muscle stress responses in Stac3 -deleted muscle to electrostimulation could be also due to defective membrane depolarization, defective voltage-dependent activation of DHPR, and/or deficient DHPR-RYR1 coupling."
27073615
CACNA1A affects PUF60
2 |
CACNA1A binds PUF60. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CACNA1A affects PLD1
| 2
CACNA1A activates PLD1. 2 / 2
| 2
sparser
"Moreover, PLD1 and HPCA were even co-localized on embryonic day 14 (E14) in the rat cerebral neocortex, and HPCA-dependent PLD1 activation was required for neuronal differentiation of NSCs."
29478139
sparser
"These results suggest that HPCA-dependent PLD1 activation is required for neuronal differentiation of NSCs."
28017654
CACNA1A affects PKC
| 2
PKC binds CACNA1A. 2 / 2
| 2
sparser
"The inhibitory effect of echinacoside on evoked glutamate release was associated with reduced voltage-dependent Ca 2+ entry and subsequent suppression of protein kinase C activity [ xref ]."
29344414
sparser
"According to these results, we suggest that the inhibitory effect of echinacoside on evoked glutamate release is associated with reduced voltage-dependent Ca 2+ entry and subsequent suppression of protein kinase C activity."
27347934
CACNA1A affects N-methyl-D-aspartic acid
| 2
CACNA1A activates N-methyl-D-aspartic acid. 2 / 2
| 2
sparser
"As seen in Figure xref , the trajectories of overall system activity, with and without NMDA receptor activation, are indeed similar in the early time period (<30 ms), but in the later time period (40–65 ms), voltage-dependent activation of NMDA current is sufficient to cause overall system activity to continue rising higher than in the condition without NMDA receptor activation."
23060751
sparser
"A slow mode, which is seen in the isolated hemicord activated with NMDA, depends on slow bursting sustained by the voltage-dependent activation of NMDA receptors, while a fast mode is seen during application of d -glutamate and does not require NMDA voltage-dependent activation ( xref )."
21111210
CACNA1A affects MS
| 2
CACNA1A binds MS.
| 1
CACNA1A binds MS. 1 / 1
| 1
sparser
"Possibly these differences give rise to the membrane-pipette interactions that allow the voltage-dependent activation of MS channels in patches formed with borosilicate glass pipettes and not with soft glass pipettes."
10354436
CACNA1A activates MS.
| 1
CACNA1A activates MS. 1 / 1
| 1
sparser
"Possibly these differences give rise to the membrane-pipette interactions that allow the voltage-dependent activation of MS channels in patches formed with borosilicate glass pipettes and not with soft glass pipettes."
10354436
CACNA1A affects MPEG1
| 2
CACNA1A binds MPEG1. 2 / 2
| 2
sparser
"This new understanding of the mechanism of MPG1 assembly and of interactions between MPG1, MHP1 and Cut2 may lead to identification of targets for disruption of rice blast infection."
27142249
sparser
"A further understanding of the molecular mechanism by which MPG1 and MHP1 assemble into the amphipathic layers and how Cut2 is activated will facilitate development of inhibitory strategies against rice blast infection."
27142249
CACNA1A affects LOXL1
| 2
CACNA1A binds LOXL1. 2 / 2
| 2
sparser
"Variants in two genes, LOXL1 and CACNA1A have been previously associated with XFS."
28553957
sparser
"We failed to detect any evidence of statistically significant interaction between CACNA1A rs4926244 and the sentinel LOXL1 polymorphisms, suggesting that both loci impact XFS risk via distinct biological pathways."
25706626
CACNA1A affects LAMB1
2 |
CACNA1A binds LAMB1. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CACNA1A affects KLHL1
2 |
CACNA1A binds KLHL1. 2 / 2
2 |
biogrid
No evidence text available
17289272
biogrid
No evidence text available
17289272
CACNA1A affects INS
| 2
CACNA1A binds INS. 1 / 1
| 1
sparser
"Hence, we have addressed the question of whether ODN influences glucose or glibenclamide-induced insulin secretion binding to voltage dependent Ca2+ channels."
7544471
CACNA1A binds ERC1 and INS. 1 / 1
| 1
sparser
"ELKS forms a potent insulin secretion complex with L-type voltage-dependent Ca 2+ channels on the vascular-facing plasma membrane of β-cells, enabling polarized Ca 2+ influx and first-phase insulin secretion from islets."
31500835
CACNA1A affects Glu-Ala
| 2
CACNA1A inhibits Glu-Ala.
| 1
CACNA1A inhibits Glu-Ala. 1 / 1
| 1
reach
"EA 2 is caused most often by the loss of function mutations of the calcium channel gene CACNA1A, which encodes the Ca (v) 2.1 subunit of the P/Q-type calcium channel and is primarily expressed in Purkinje cells."
17395137
CACNA1A activates Glu-Ala.
| 1
Mutated CACNA1A activates Glu-Ala. 1 / 1
| 1
reach
"EA 2 is most often caused by mutations of the CACNA1A gene encoding the alpha-subunit of P/Q-type calcium channel [XREF_BIBR]."
24222635
CACNA1A affects GSR
| 2
CACNA1A inhibits GSR. 2 / 2
| 2
sparser
"Mathematical modeling eliminated the possibilities of the involvements of I h deactivation and/or shunting effect and supported the negative shift of E h which causes the U-shaped voltage-dependent inhibition of I GluR ."
29740287
sparser
"Furthermore, the I h deactivation failed to simulate the U-shaped voltage-dependent inhibition of IN- I GluR or the U-shaped voltage-dependent generation of OT- I GluR (Figures xref )."
29740287
CACNA1A affects GJ
| 2
GJ binds CACNA1A. 2 / 2
| 2
sparser
"Connexin hemichannels display two distinct forms of voltage-dependent gating, corresponding to the operation of Vj- or fast gates and loop- or slow gates."
24047988
sparser
"The structure of the pore is critical to understanding the molecular mechanisms underlying selective permeation and voltage-dependent gating of channels formed by the connexin gene family."
19468074
CACNA1A affects FHM
| 2
CACNA1A activates FHM. 1 / 1
| 1
reach
"We now report on a mutation identified in the first intracellular loop of CACNA1A (alpha (1A (A454T))) that does not cause FHM but is associated with the absence of sensorimotor symptoms in a migraine with aura pedigree."
20080591
Mutated CACNA1A activates FHM. 1 / 1
| 1
reach
"Gene mutations of CACNA1A, SCN1A, and ATP1A2 can cause FHM and we investigated only CACNA1A gene mutation in the present case that revealed negative result."
28101483
CACNA1A affects EC
| 2
CACNA1A inhibits EC. 2 / 2
| 2
sparser
"This occurs under these conditions because of voltage-dependent inactivation of EC coupling ( xref )."
29899059
sparser
"Voltage-dependent inactivation of EC coupling."
23630336
CACNA1A affects EA-2
| 2
CACNA1A activates EA-2. 2 / 2
| 2
reach
"EA-2 is caused by mutations of calcium channel gene CACNA1A on chromosome 19p13 that encodes the Ca voltage 2.1 subunit of the P/Q-type calcium channel."
18718348
reach
"EA-1 is due to different heterozygous missense point mutations in a voltage gated (delayed rectifier) potassium channel gene (KCNA1 and Kv1.1) on chromosome 12p13, whereas EA-2 is caused by mutations of the cerebral P/Q-type calcium channel alpha 1 subunit gene CACNL1A4 localized on chromosome 19p, which is highly expressed in the cerebellum."
9390841
CACNA1A affects CSNK2B
2 |
CACNA1A binds CSNK2B. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CACNA1A affects CD79A
| 2
CACNA1A activates CD79A. 2 / 2
| 2
reach
"The Ca2+ channel stimulated by the presence of the (32 subunit may contribute an inactivating, DHP-insensitive component of Iga to the total current in a, Da2b."
1309651
reach
"Coexpression of the a26 subunit enhances the Iga, but a26 mRNA shows no activity when injected alone."
1309651
CACNA1A affects CD62L-
| 2
CACNA1A activates CD62L-. 2 / 2
| 2
reach
"B/I selectively activates CD62L- T cells, which represent the " sensitized " T cells capable of anti-tumor activity and is unique to B/I activation compared to anti-CD3 activation [XREF_BIBR, XREF_BIBR]."
25903148
reach
"In the 4T1 mammary carcinoma model, we have previously shown that B/I selectively activates CD62L- or sensitized T cells and that the anti-tumor activity resides in the CD62L- fraction of lymphocytes obtained from donor lymph nodes; only the CD62L- subset proliferates after B/I activation and has anti-tumor activity [XREF_BIBR]."
19198835
CACNA1A affects CC2D2A
| 2
CACNA1A binds CC2D2A. 1 / 1
| 1
sparser
"Mutations in the CACNA1A gene are associated with episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6)."
20948794
Calcium_channels binds Myosin_complex, CACNA1A, CC2D2A, and GTF2B. 1 / 1
| 1
sparser
"Ablation of myosin-IIB in mice is embryonic lethal, and myosin-IIB ( MYH10 ) mutations are thought to be embryonic lethal in humans, as well; however, myosin-IIB function has been associated with the pathogenesis of spinocerebellar ataxia type 6 (SCA6) through associations of myosin-IIB and Cav2.1 calcium channel polyglutamate tracts [ xref ]."
20850431
CACNA1A affects CASP3
| 2
CACNA1A increases the amount of CASP3.
| 1
CACNA1A increases the amount of CASP3. 1 / 1
| 1
reach
"Nonetheless, these findings strongly suggest that BI-TK and GCV gene therapy system may upregulate Caspase 3 expression in bladder tumors and hence promote bladder tumor cell apoptosis."
20015348
CACNA1A activates CASP3.
| 1
CACNA1A activates CASP3. 1 / 1
| 1
reach
"XREF_BIBR SCA1, SCA2, Machado-Joseph or SCA3, SCA6, SCA7, SCA12, SCA17, and dentatorubral-pallidoluysian atrophy (DRPLA) are caused by (CAG) n repeat expansions in the ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, PPP2R2B, TBP, and ATN1 genes, respectively, and all lead to the expansion of a polyglutamine tract in the corresponding proteins."
24780882
CACNA1A affects CA2
| 2
CACNA1A inhibits CA2.
| 1
CACNA1A inhibits CA2. 1 / 1
| 1
sparser
"The identification of A-1048400 provides further evidence that voltage-dependent inhibition of neuronal Ca²⁺ channels coupled with pharmacological selectivity vs. L-type Ca²⁺ channels can provide robust antinociception in the absence of deleterious effects on hemodynamic or psychomotor function."
22153861
CACNA1A activates CA2.
| 1
CACNA1A activates CA2. 1 / 1
| 1
sparser
"Thus the important hyperpolarizing shift in the voltage-dependent activation of Ca2.1 mutants appears as an important functional feature leading to FMH1 with ataxia."
24836863
CACNA1A affects BAX
| 1 1
CACNA1A inhibits BAX.
| 1
CACNA1A inhibits BAX. 1 / 1
| 1
reach
"However, as the suppression of Bax induced lethality by expression of BI-GST appears very efficient, in fact comparable with inhibition by Bcl-2, and as the expression of BI-GST suppresses effects of Bax on mitochondrial and vacuolar morphology XREF_BIBR, it may not be ruled out that BI-GST actually impairs the ability of Bax to create pores in mitochondrial membranes."
28357280
CACNA1A binds BAX.
| 1
CACNA1A binds BAX. 1 / 1
| 1
sparser
"Moreover, the release of cytochrome c from the mitochondria is dependent on cyclosporin A-sensitive mitochondrial permeability transition pore opening, but not formation of the Bax-voltage dependent anion channel complex or Bax oligomeric pores."
26164288
CACNA1A affects ATXN2
| 1 1
ATXN2 binds CACNA1A. 1 / 1
| 1
reach
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A."
24534762
ATXN1 binds ATXN2, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A. Intermediate-length polyQ expansions (>24 Qs) of ATXN2 were found in 7 ADPD patients and no controls (7/299 = 2.34% and 0/329 = 0%, respectively; p = 0.0053 < 0.05/8 after Bonferroni correction)."
24534762
CACNA1A affects ATXN1
| 1 1
ATXN1 binds CACNA1A. 1 / 1
| 1
reach
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A."
24534762
ATXN1 binds ATXN2, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A. Intermediate-length polyQ expansions (>24 Qs) of ATXN2 were found in 7 ADPD patients and no controls (7/299 = 2.34% and 0/329 = 0%, respectively; p = 0.0053 < 0.05/8 after Bonferroni correction)."
24534762
CACNA1A affects ATPase activity
| 2
CACNA1A inhibits ATPase activity.
| 1
CACNA1A inhibits ATPase activity. 1 / 1
| 1
sparser
"This surprising result is highly reminiscent of the voltage-dependent inhibition of the Na-K ATPase by extracellular Na + ( xref ; xref )."
20513761
ATPase activity binds CACNA1A. 1 / 1
| 1
sparser
"It; should also 520 S. Persad et aI. ~Pable 7 Modification ofoubain-sensitive (Na+-K+)-ATPase and calcium channel binding activities by deoxycholate treatment Oubain- sensitive [~HI PN200-1] 0 binding (Na +-K ~ )-ATPase ...... (#too/Pjmg/h) Kd (riM) Bma.~ (fmoI/mg) Control 7.8 0.5 0.46 0.05 170 18 DOC treatment 7.6 0.6 0.44 0.04 221 22" Crude membranes were incubated without or with deoxycho/ate (DOC/prntein ratio 0.5) at 30: for 10 rain."
7760371
CACNA1A affects ARHGAP22
2 |
CACNA1A binds ARHGAP22. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CACNA1A affects AMIGO2
2 |
CACNA1A binds AMIGO2. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CACNA1A affects ADGRL1
2 |
CACNA1A binds ADGRL1. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CACNA1A affects ABI1
2 |
ABI1 binds CACNA1A. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
CACNA1A affects 2-methylpropanamine
| 2
CACNA1A inhibits 2-methylpropanamine. 2 / 2
| 2
sparser
"The voltage-dependent inactivation of the IBa proceeded with two time constants [190 +/- 21 and 2020 +/- 146 msec (N = 4) at -10 mV], both of which were shortened by adding 1 mM pentobarbital [to 120 +/- 18 and 540 +/- 51 msec (N = 4), respectively]."
2433043
sparser
"Voltage-dependent inactivation of IBa was slower than for Cav1.2alpha1 and Cav1.3alpha1( approximately 50% inactivation after 5 sec; alpha2delta1 + beta3 coexpression)."
12853422
CABP1 affects CACNA1A, and VSNL1
| 2
VSNL1 binds CABP1 and CACNA1A. 2 / 2
| 2
sparser
"These studies reveal that CaBP1 and VILIP-2 bind to the same site with opposite effects on Cav2.1."
30061813
sparser
"These results suggest a model in which nonmyristoylated CaBP1 and VILIP-2 bind to CaV2.1 channels and regulate them like CaM, whereas myristoylation allows differential, Ca2+-independent regulation by the inactive EF-hands of CaBP1 and VILIP-2, which differ in their positions in the protein structure."
16049184
ATXN2 affects CACNA1A
| 1 1
ATXN2 binds CACNA1A. 1 / 1
| 1
reach
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A."
24534762
ATXN1 binds ATXN2, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A. Intermediate-length polyQ expansions (>24 Qs) of ATXN2 were found in 7 ADPD patients and no controls (7/299 = 2.34% and 0/329 = 0%, respectively; p = 0.0053 < 0.05/8 after Bonferroni correction)."
24534762
ATXN1 affects CACNA1A
| 1 1
ATXN1 binds CACNA1A. 1 / 1
| 1
reach
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A."
24534762
ATXN1 binds ATXN2, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A. Intermediate-length polyQ expansions (>24 Qs) of ATXN2 were found in 7 ADPD patients and no controls (7/299 = 2.34% and 0/329 = 0%, respectively; p = 0.0053 < 0.05/8 after Bonferroni correction)."
24534762
ATP1A2 affects CACNA1A, and SCN1A
| 2
SCN1A binds CACNA1A and ATP1A2. 1 / 1
| 1
sparser
"FHM may be associated with mutations in the genes CACNA1A (FHM1), ATP1A2 (FHM2) and SCN1A (FHM3) [ xref ]."
22661290
SCN1A binds CACNA1A, ATP1A2, and ATP1A2. 1 / 1
| 1
sparser
"Mutations in CACNA1A, ATP1A2 and SCN1A genes have been associated with familial hemiplegic migraine (FHM), a rare monogenic form of migraine [ xref ]."
23566281
ARHGAP22 affects CACNA1A
2 |
CACNA1A binds ARHGAP22. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
ANK2 affects CACNA1A, and CACNA1B
| 2
CACNA1A binds CACNA1B and ANK2. 2 / 2
| 2
sparser
"Here, we demonstrate that ankyrin-B associates with Cav2.1 and Cav2.2 in cortex, cerebellum, and brain stem."
24394417
sparser
"Collectively, our findings identify an interaction between ankyrin-B and both Cav2.1 and Cav2.2 at the amino acid level that is necessary for proper Cav2.1 and Cav2.2 targeting in vivo."
24394417
AMIGO2 affects CACNA1A
2 |
CACNA1A binds AMIGO2. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
ADGRL1 affects CACNA1A
2 |
CACNA1A binds ADGRL1. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
ABI1 affects CACNA1A
2 |
ABI1 binds CACNA1A. 2 / 2
2 |
biogrid
No evidence text available
21078624
biogrid
No evidence text available
21078624
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile affects CACNA1A
| 1 1
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile inhibits CACNA1A. 1 / 1
| 1
sparser
"High influx of extracellular calcium leads to chemoresistance and calcium channel inhibition by verapamil attenuates chemoresistance [39] ."
24239173
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile activates CACNA1A. 1 / 1
| 1
reach
"The present review deals with recent scientific studies according to which : The SHM prevalence is estimated to be 0.005%; SHM patients have clinical symptoms identical to patients with familial hemiplegic migraine (FHM) and significantly different from patients with migraine with typical aura (typical MA); SHM affected had no increased risk of migraine without aura (MO), but a highly increased risk of typical MA compared to the general population; SHM patients only rarely have mutations in the FHM gene CACNA1A; SHM attacks in some cases can be treated with Verapamil."
15566415
WtRFX6 affects CACNA1A
| 1
WtRFX6 activates CACNA1A. 1 / 1
| 1
reach
"However, overexpression of wtRFX6 significantly increased CACNA1A, CACNB2, and CACNA1D, which is not observed upon Mut506RFX6 expression."
25497100
Vs affects CACNA1A
| 1
CACNA1A binds vs. 1 / 1
| 1
sparser
"We identified specific interactions between the PAS, CNBHD, and VS that modulate voltage-dependent gating and provide evidence that VS movement destabilizes these interactions to promote channel opening."
31490124
VraC affects CACNA1A
| 1
VraC inhibits CACNA1A. 1 / 1
| 1
sparser
"Fig. 4 shows current traces of voltage-dependent VRAC inactivation in wild-type tsA201a and T84 I Cln transfected cells in response to a family of voltage pulses."
10825435
TrpC affects CACNA1A
| 1
TrpC activates CACNA1A. 1 / 1
| 1
reach
"Comparison of the biophysical properties of these TRP channels with basally active NSCC (bI (NSCC)) suggests that TRPM4 and specific TRPC heteromultimer combinations may underlie the three single-channel conductances of bI (NSCC)."
21566016
Translocator affects CACNA1A
| 1
CACNA1A binds translocator. 1 / 1
| 1
sparser
"It has been proposed that the mPTP is formed through conformational change in the association of the adenine nucleotide translocator (ANT) with the voltage dependent anion channel (VDAC) contact sites between the inner and outer mitochondrial membranes [ xref , xref ]."
22482055
Tmd affects CACNA1A
| 1
CACNA1A binds tmd. 1 / 1
| 1
sparser
"Zn 2+ inhibits GluN2A with a high affinity by binding with NTD, and inhibits other GluN2 subunit containing NMDA receptors by binding only with the voltage dependent low affinity binding site at the TMD."
28536523
Thapsigargin affects CACNA1A
| 1
Thapsigargin inhibits CACNA1A. 1 / 1
| 1
sparser
"We also show that LVA calcium channels present strong voltage-dependent inhibition by thapsigargin."
12453461
Tellurium atom affects CACNA1A
| 1
Tellurium atom binds CACNA1A. 1 / 1
| 1
reach
"They further noted that neuron related genes such as GPM6A, SYT4, GRIK1, LPP9, and CACNA1A were significantly associated with TE; cell signaling genes, AKAP11, PTPN2, and NRP2 were associated with SE; and that 17 other genes, including ZFP42, CDH22, ALDH1A2, OTX2, and EN2 were associated with SY."
30376909
Symporter activity affects CACNA1A
| 1
Symporter activity binds CACNA1A. 1 / 1
| 1
sparser
"Further insight into the interaction of protons with the voltage-dependent kinetics of type II Na/P cotransporters is reflected in the time course and magnitude of pre-steady-state relaxations induced by voltage steps ()."
10866949
SinR affects CACNA1A
| 1
SinR inhibits CACNA1A. 1 / 1
| 1
sparser
"As shown in [23], the release of the voltage-dependent inactivation by tryp- sin is a characteristic property of the animal voltage- gated potassium channels."
7506216
Sertraline affects CACNA1A
| 1
Sertraline inhibits CACNA1A. 1 / 1
| 1
sparser
"Furthermore, sertraline inhibits various voltage-dependent channels including Ca 2+ channels, Na + channels and K + channels [ xref xref xref xref xref xref ]."
26937216
Ryanodine receptor affects CACNA1A
| 1
CACNA1A binds ryanodine receptor. 1 / 1
| 1
sparser
"This occurs when the Ryanodine receptor (RyR1) on the sarcoplasmic reticular (SR) membrane interacts with voltage-dependent Ca 2+ channels on the T-tubules such as dyhydropyridine receptors (DHPRs) and allows calcium release from the SR into the sarcoplasm when activated xref ."
24270550
Pyraclofos affects CACNA1A
| 1
Pyraclofos activates CACNA1A. 1 / 1
| 1
sparser
"The MWC model soon was adapted to account for the agonist activation of the nicotinic acetylcholine receptors (nAChRs) ( xref ), and a version of the KNF model, in which the T↔R equilibrium varies as a function of the membrane potential difference, has been extensively used to account for the voltage activation of voltage-dependent channels."
23183695
PstS affects CACNA1A
| 1
CACNA1A binds pstS. 1 / 1
| 1
sparser
"Interaction of charged and uncharged calcium channel antagonists with phos- pholipid memhranes."
7760349
Potassium chloride affects CACNA1A
| 1
Potassium chloride activates CACNA1A. 1 / 1
| 1
sparser
"KCl activates voltage-dependent channels i.e. Na + and Ca 2+ and is a measure of the general excitability of the preparation."
22563480
Phencyclidine affects CACNA1A
| 1
Phencyclidine binds CACNA1A. 1 / 1
| 1
sparser
"Ketamine is a dissociative anaesthetic drug which has been shown to bind selectively to the PCP recognition site in the NMDA receptor-gated calcium channel (Lodge and Johnsson, 1990; 0ye et al., 1992)."
9234346
PepA affects CACNA1A
| 1
CACNA1A binds pepA. 1 / 1
| 1
sparser
"AmpA forms voltage-dependent ion conducting pores in eggPC planar bilayers [ xref ], the hydrophobic core thickness of which has been estimated to be 26 Å by others [ xref ]."
21403824
Pcs affects CACNA1A
| 1
CACNA1A binds pcs. 1 / 1
| 1
sparser
"Atypical slow CF responses of GluRdelta2 mutant PCs were associated with voltage-dependent Ca(2+) signals that were confined to PC distal dendrites."
11739579
P-menthan-3-ol affects CACNA1A
| 1
P-menthan-3-ol activates CACNA1A. 1 / 1
| 1
sparser
"TRPM8 currents are predominantly outwardly-rectifying [13] , although cooling shifts the voltage-dependent activation by menthol from depolarized potentials to those of the physiologic range [25] ."
18485891
Neuraminidase affects CACNA1A
| 1
Neuraminidase activates CACNA1A. 1 / 1
| 1
reach
"When an aliquot of B-I was treated with neuraminidase and reapplied to Sephadex G-25, all of the Morgan-Elson chromogen was eluted in Fraction D, at an efuent volume slightly less than that of glucose."
4710767
MiR-4786-3p affects CACNA1A
| 1
MiR-4786-3p decreases the amount of CACNA1A. 1 / 1
| 1
reach
"qRT-PCR studies of total RNA showed that miR-711 and miR-4786-3p decreased CACNA1A mRNA expression relative to a negative control miRNA, but miR-3191-5p did not affect either CACNA1A-Q11 or CACNA1A-Q33 mRNA expression (XREF_FIG)."
27412786
Lpp affects CACNA1A
| 1
Lpp activates CACNA1A. 1 / 1
| 1
reach
"MLPA and QMPSF allowed inspection of 40 out of 48 CACNA1A exons."
28566750
Lithium chloride affects CACNA1A
| 1
Lithium chloride inhibits CACNA1A. 1 / 1
| 1
reach
"Interestingly, Acebutolol and Lithium chloride induced similar inhibitory effect of BI-78D3 in JNK phosphorylation of these cells (XREF_FIG)."
29129046
Lidocaine affects CACNA1A
| 1
Lidocaine inhibits CACNA1A. 1 / 1
| 1
sparser
"These results, considered together with the voltage-dependent inhibition by lidocaine of GABA-induced currents of the α1β2γ2s subunit receptor, and the phenomenon observed with the β2 homomeric receptors, are consistent with the hypothesis that an effect of local anesthetics on GABA A receptors may result from the blockade of the chloride channel pore."
10936490
KcsA affects CACNA1A
| 1
CACNA1A binds kcsA. 1 / 1
| 1
sparser
"Voltage-dependent Interactions of Na + Ions with KcsA."
12198089
Isocyanic acid affects CACNA1A
| 1
Isocyanic acid inhibits CACNA1A. 1 / 1
| 1
sparser
"There were no significant differences in the indices of voltage dependent Ica inactivation between the SVT car- diomyopathy and control groups."
8531216
Hsa-miR-744-5p affects CACNA1A
1 |
Transcriptionally active hsa-miR-744-5p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-6893-3p affects CACNA1A
1 |
Transcriptionally active hsa-miR-6893-3p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-6793-3p affects CACNA1A
1 |
Transcriptionally active hsa-miR-6793-3p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6516-3p affects CACNA1A
1 |
Transcriptionally active hsa-miR-6516-3p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-642b-5p affects CACNA1A
1 |
Transcriptionally active hsa-miR-642b-5p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-607 affects CACNA1A
1 |
Transcriptionally active hsa-miR-607 decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-5695 affects CACNA1A
1 |
Transcriptionally active hsa-miR-5695 decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-548c-3p affects CACNA1A
1 |
Transcriptionally active hsa-miR-548c-3p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-519e-5p affects CACNA1A
1 |
Transcriptionally active hsa-miR-519e-5p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-519d-5p affects CACNA1A
1 |
Transcriptionally active hsa-miR-519d-5p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-515-5p affects CACNA1A
1 |
Transcriptionally active hsa-miR-515-5p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4749-5p affects CACNA1A
1 |
Transcriptionally active hsa-miR-4749-5p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-4734 affects CACNA1A
1 |
Transcriptionally active hsa-miR-4734 decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-4706 affects CACNA1A
1 |
Transcriptionally active hsa-miR-4706 decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-4485-5p affects CACNA1A
1 |
Transcriptionally active hsa-miR-4485-5p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-4307 affects CACNA1A
1 |
Transcriptionally active hsa-miR-4307 decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-370-3p affects CACNA1A
1 |
Transcriptionally active hsa-miR-370-3p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-3671 affects CACNA1A
1 |
Transcriptionally active hsa-miR-3671 decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-33a-3p affects CACNA1A
1 |
Transcriptionally active hsa-miR-33a-3p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-2355-5p affects CACNA1A
1 |
Transcriptionally active hsa-miR-2355-5p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-186-3p affects CACNA1A
1 |
Transcriptionally active hsa-miR-186-3p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-148a-5p affects CACNA1A
1 |
Transcriptionally active hsa-miR-148a-5p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-1260b affects CACNA1A
1 |
Transcriptionally active hsa-miR-1260b decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-1260a affects CACNA1A
1 |
Transcriptionally active hsa-miR-1260a decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-1224-3p affects CACNA1A
1 |
Transcriptionally active hsa-miR-1224-3p decreases the amount of CACNA1A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hemolysin affects CACNA1A
| 1
CACNA1A binds hemolysin. 1 / 1
| 1
sparser
"Menestrina, G. and Ropele, M. (1989) Voltage-dependent gating properties of the channel formed by E. coli hemolysin in planar lipid membranes."
8160187
HTMEM266 affects CACNA1A
| 1
CACNA1A binds hTMEM266. 1 / 1
| 1
sparser
"HTMEM266 has been reported to localize on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum ( xref ), and having established that hTMEM266 is a functional voltage sensor it will be exciting to explore whether hTMEM266 can specifically interact with intracellular signaling pathways to provide voltage-dependent regulation."
30810529
GacH affects CACNA1A
| 1
GacH activates CACNA1A. 1 / 1
| 1
reach
"Mutant gene products of both CACNA1A and ATP1A2 may affect neurotransmission of glutamate, the most abundant excitatory amino acid neurotransmitter."
16116111
Ethanol affects CACNA1A
| 1
Ethanol activates CACNA1A. 1 / 1
| 1
reach
"We have previously shown that caffeine, EtOH, and stress reliably trigger attacks in the spontaneous Cacna1a mouse mutant tottering, demonstrating that episodic attacks of neurological dysfunction caused by Cacna1a mutations can be induced in mice."
25109669
Dronedarone affects CACNA1A
| 1
Dronedarone inhibits CACNA1A. 1 / 1
| 1
sparser
"Also, we show that, while amiodarone inhibits the Cole-Moore shift, dronedarone is unable to inhibit this voltage-dependent characteristic of Kv10.1."
31897736
Dioxygen affects CACNA1A
| 1
Dioxygen inhibits CACNA1A. 1 / 1
| 1
sparser
"Idikuda et al. show that, in the case of the sea urchin hyperpolarization-activated cyclic nucleotide–gated channel, a histidine residue in S6 is essential for the abolition of voltage-dependent inactivation by singlet oxygen."
30042141
Dihydropyridine affects CACNA1A
| 1
Dihydropyridine binds CACNA1A. 1 / 1
| 1
sparser
"These data suggest that dihydropyridine calcium channel antagonists and activators bind to different allosterically linked receptors or domains of the dihydropyridine protein associated with the voltage-dependent calcium channels."
7530159
Dihydrogen affects CACNA1A
| 1
Dihydrogen activates CACNA1A. 1 / 1
| 1
sparser
"A similar divalent binding site is conserved in Elk and Erg family channels ( xref ; xref ; xref ; xref ), providing a possible explanation for inhibition of voltage-dependent activation by protons in Kv11.1 and Kv12.1."
23712551
Cytokine affects CACNA1A
| 1
CACNA1A binds cytokine. 1 / 1
| 1
sparser
"APCA may also be associated with cytokines, which may enhance embryonic and trophoblast development."
1285902
Conotoxin affects CACNA1A
| 1
CACNA1A binds conotoxin. 1 / 1
| 1
sparser
"Concentrations of (±)-AR-A008055 or either enantiomer up to a concentration of 1 mM failed to produce significant displacement of [ 3 H ] dizocilpine binding to the NMDA receptor, [ 3 H ] AMPA binding to the AMPA receptor, [ 125 I ] ω-conotoxin MVIIC binding to N or P/Q type calcium channels or [ 3 H ] batrachotoxin binding to the sodium channel."
11489453
Calcium-binding affects CACNA1A
| 1
CACNA1A binds calcium-binding. 1 / 1
| 1
sparser
"CCMM animals present a decline of the density of Purkinje cells, with a diminished Cav2.1 activity associated with a decrease in the expression of calcium-binding proteins ( Dove et al ., 2000; Herrup and Wilczynski, 1982 )."
21907100
Caffeine affects CACNA1A
| 1
Caffeine activates CACNA1A. 1 / 1
| 1
reach
"We have previously shown that caffeine, EtOH, and stress reliably trigger attacks in the spontaneous Cacna1a mouse mutant tottering, demonstrating that episodic attacks of neurological dysfunction caused by Cacna1a mutations can be induced in mice."
25109669
Caesium(1+) affects CACNA1A
| 1
Caesium(1+) inhibits CACNA1A. 1 / 1
| 1
sparser
"x channels, particularly Kir2.1: 1) current-voltage relationship with strong inward rectification, 2) slope conductance approximately proportional to the square root of external K(+) concentration, 3) voltage- and time-dependent and high-affinity block by external Ba(2+), and 4) voltage-dependent inhibition by external Cs(+)."
24259419
Caesium atom affects CACNA1A
| 1
Caesium atom inhibits CACNA1A. 1 / 1
| 1
sparser
"Cesium inhibits voltage-dependent, inward-rectifying potassium channels, and subsequently induces potassium starvation in plants."
25946015
Bryostatin affects CACNA1A
| 1
Bryostatin activates CACNA1A. 1 / 1
| 1
reach
"Expansion and cytokine secretion of bryostatin activated T-cells 277 Phenotypic analysis of B/I expanded cells Table 2 shows the phenotypes of B/I expanded cells with respect to the cell surface markers CD3, CD8 and CD4."
8305969
Barium(2+) affects CACNA1A
| 1
Barium(2+) activates CACNA1A. 1 / 1
| 1
sparser
"C m responses were inhibited by the Ca 2+ channel blocker Cd 2+ and the threshold voltage for C m increases mirrored the threshold for voltage-dependent Ba 2+ current activation."
21048127
Baclofen affects CACNA1A
| 1
Baclofen inhibits CACNA1A. 1 / 1
| 1
sparser
"Depolarizing paired pulses revealed that ∼75% of the baclofen inhibition of Cav2.1 was voltage dependent and could be relieved by strong depolarization."
24688019
BC affects CACNA1A
| 1
CACNA1A binds bC. 1 / 1
| 1
reach
"Therefore, the presence of F6 enhances the binding of b ', bI and bC to F, ~ OSCP, although F6 does not appear to form a strong direct interaction with the binary complex."
8206156
Anxa3a affects CACNA1A
| 1
CACNA1A binds anxa3a. 1 / 1
| 1
sparser
"This paper describes for the first time the voltage dependent binding of annexins to membrane bilayers."
9408179
Acebutolol affects CACNA1A
| 1
Acebutolol inhibits CACNA1A. 1 / 1
| 1
reach
"Interestingly, Acebutolol and Lithium chloride induced similar inhibitory effect of BI-78D3 in JNK phosphorylation of these cells (XREF_FIG)."
29129046
ZNF233 affects CACNA1A
1 |
CACNA1A binds ZNF233. 1 / 1
1 |
biogrid
No evidence text available
21078624
ZCCHC17 affects CACNA1A
1 |
CACNA1A binds ZCCHC17. 1 / 1
1 |
biogrid
No evidence text available
21078624
WHAMM affects CACNA1A
| 1
CACNA1A binds WHAMM. 1 / 1
| 1
sparser
"The data obtained suggest that interactions of microtubules and voltage-dependent calcium channels by either direct or indirect mechanisms inhibit channel activities and decrease their half-life."
8804414
WBP1 affects CACNA1A
1 |
WBP1 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
VWF affects CACNA1A
1 |
VWF binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
VSNA1 affects CACNA1A
| 1
CACNA1A binds VSNA1. 1 / 1
| 1
sparser
"It was shown that the defensin forms voltage-dependent channels in the bacteria, and disrupts the permeability barrier of the cytoplasmic membrane of the bacteria, resulting in loss of cytoplasmic potassium, a partial depolarization of the inner membrane, a decrease in cytoplasmic ATP, and inhibition of respiration xref ."
23056609
VPS52 affects CACNA1A
1 |
VPS52 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
VDCC beta4 affects CACNA1A
| 1
VDCC beta4 activates CACNA1A. 1 / 1
| 1
reach
"Additionally, Purkinje cell bodies appeared to have increased VDCC beta4 signal in the Cacna1a -/-."
22107844
VARS1 affects CACNA1A
1 |
VARS1 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
UQCRC2 affects CACNA1A
1 |
UQCRC2 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
UBE2L3 affects CACNA1A
1 |
UBE2L3 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
25483588
TYRP1 affects CACNA1A
| 1
TYRP1 binds CACNA1A. 1 / 1
| 1
sparser
"This finding is in line with the observation that some indole metabolites of TRP (e.g., oxindole), demonstrate sedative properties; these sedative properties occur due to the interaction of these TRP metabolites with voltage-dependent Na+channels ( Carpenedo et al., 1998; Moroni, 1999 )."
26601775
TSPO affects CACNA1A
| 1
TSPO binds CACNA1A. 1 / 1
| 1
sparser
"A series of ACBD3 suppression and overexpression studies, along with expression of dominant negative mutants and in vitro reconstitution experiments in steroid synthesizing and control cells, support the idea that upon hormonal stimulation, the mitochondrial proteins TSPO and voltage-dependent anion-selective channel (VDAC) form a complex that allows for the recruitment and anchoring of ACBD3, PRKAR1A, ACBD1 and StAR on the surface of the mitochondria and subsequent cholesterol transfer [ xref , xref , xref , xref , xref , xref ]."
20043945
TSPAN7 affects CACNA1A
1 |
TSPAN7 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
TSC22D1 affects CACNA1A
1 |
CACNA1A binds TSC22D1. 1 / 1
1 |
biogrid
No evidence text available
21078624
TELO2 affects CACNA1A
1 |
CACNA1A binds TELO2. 1 / 1
1 |
biogrid
No evidence text available
21078624
TEA affects CACNA1A
| 1
CACNA1A binds TEA. 1 / 1
| 1
sparser
"Moreover, such a binding site for nystatin is likely to be different from that for TEA, which binds in a voltage-dependent manner to the inner mouth of the pore (; )."
8938720
TCTN3 affects CACNA1A
1 |
CACNA1A binds TCTN3. 1 / 1
1 |
biogrid
No evidence text available
26638075
TCTN2 affects CACNA1A
1 |
CACNA1A binds TCTN2. 1 / 1
1 |
biogrid
No evidence text available
26638075
TCN1 affects CACNA1A
| 1
TCN1 activates CACNA1A. 1 / 1
| 1
sparser
"We conclude that (a) functional Cx43 HCs are present in ventricular cardiomyocytes, (b) when [Ca 2+ ] i is moderately elevated, these channels open at V m = + 40 mV, and (c) CxMPs prevent Ca 2+ and voltage-dependent HC activation."
23095853
TAF15 affects CACNA1A
1 |
TAF15 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
SYP affects CACNA1A
| 1
SYP binds CACNA1A. 1 / 1
| 1
sparser
"Indeed, reconstitution studies have suggested that synaptophysin forms voltage-dependent cation channels (Thomas et al., 1988), similar to cation channels found in patch-clamped fused synaptic vesicles from Torpedo (Rahamimoff et al., 1989)."
7507717
SYNJ1 affects CACNA1A
| 1
SYNJ1 dephosphorylates CACNA1A. 1 / 1
| 1
sparser
"Thanks to two consecutive phosphatase domains, Sac1 and 5′-phosphatase, Synj1 mainly dephosphorylates PI bi- or trisphosphates localised in plasma membranes, and PI monophosphates, PI(4)P and PI(3)P, enriched in the membranes of Golgi apparatus and endosomes, respectively xref ."
29515184
SUMF2 affects CACNA1A
1 |
CACNA1A binds SUMF2. 1 / 1
1 |
biogrid
No evidence text available
21078624
SST affects CACNA1A
| 1
SST binds CACNA1A. 1 / 1
| 1
sparser
"SST binding to the G-protein-coupled receptors (SSTR1-SSTR5) that are directly linked to voltage-dependent Ca 2+ channels inhibits Ca 2+ channel activity and associated downstream events."
27787949
SRSF1 affects CACNA1A
1 |
SRSF1 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
SRRM4 affects CACNA1A
1 |
CACNA1A binds SRRM4. 1 / 1
1 |
biogrid
No evidence text available
21078624
SRC affects CACNA1A
| 1
SRC phosphorylates CACNA1A. 1 / 1
| 1
rlimsp
"We systematically examined the intracellular pathways and elucidated the molecular details that determine c-Src phosphorylation of the Cav2.1 and Cav2.3 channel C termini."
24688019
SPRY1 affects CACNA1A
1 |
SPRY1 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
SLC25A10 affects CACNA1A
| 1
SLC25A10 inhibits CACNA1A. 1 / 1
| 1
sparser
"These features are most likely caused by the same channel, which is released from a voltage-dependent inhibition by extracellular DICs and closely resemble the properties of the poorly selective and Mg 2+ -inhibited cation channel TRPM7 ( xref ), which is widely expressed in untransformed or in tumor cells, including HEK293 ( xref )."
27185858
SIGMAR1 affects CACNA1A
| 1
CACNA1A binds SIGMAR1. 1 / 1
| 1
sparser
"This protein is involved in the transport of cholesterol from ER to mitochondria via interaction with the two mitochondria-associated membrane proteins sigma1 receptor and voltage-dependent anion-selective channel (VDAC) protein (Marriott et al. xref )."
27449929
SCP2 affects CACNA1A
1 |
SCP2 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
SCA affects CACNA1A
| 1
SCA activates CACNA1A. 1 / 1
| 1
reach
"The earlier ataxia interactome provided new insight into the pathogenesis of inherited ataxias, but it lacked interactors for two SCA causing proteins, CACNA1A and ataxin-7."
21078624
SAG affects CACNA1A
| 1
CACNA1A binds SAG. 1 / 1
| 1
sparser
"The voltage-dependent activation of the conductance(s) responsible for this sag has commonly been associated with resonance properties."
24399930
RyR affects CACNA1A
| 1
RyR activates CACNA1A. 1 / 1
| 1
sparser
"It has been shown that in addition to the II-III loop of the DHPR, which may modulate transverse tubular voltage–dependent RyR activation ( xref , xref ), Ca 2 + release from RyR in skeletal muscle is modulated by endogenous ligands such as Ca 2 + and Mg 2 + ( xref ; xref ; xref ) as well as regulatory proteins such as calmodulin and FKBP12 ( xref ; xref ; xref )."
11773235
Ro-32-0432 affects CACNA1A
| 1
Ro-32-0432 inhibits CACNA1A. 1 / 1
| 1
reach
"Go6976 inhibits PKC with particular specificity for the classic PKC isoforms a, bI, and bII but also for atypical PKCm [19], whereas Ro-32-0432 selectively inhibits iso-forms a and bI [20]."
16229809
Reactive Oxygen Species affects CACNA1A
| 1
Reactive Oxygen Species activates CACNA1A. 1 / 1
| 1
sparser
"ROS can activate voltage sensitive calcium channel and increase intracellular calcium that could lead to vasospasm xref , xref ; all of which can be blocked by nimodipine, a calcium channel blocker."
23029446
RPS17 affects CACNA1A
1 |
RPS17 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
RPL31 affects CACNA1A
1 |
RPL31 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
RBBP8 affects CACNA1A
| 1
CACNA1A binds RBBP8. 1 / 1
| 1
sparser
"These genes included: (1) 2 complexins (CPLX1 and CPLX2) and 3 synaptotagmins (SYT1, SYT2, and SYT3), which together regulate calcium-dependent exocytosis xref , xref ; (2) one of the synapsins (SYN2) which are involved in vesicle tethering and controlling the number of vesicles available for release xref ; (3) synaptophysin (SYP) which binds synaptobrevin (VAMP1) and plays a role in the control of exocytosis xref ; (4) one of the RIM family members (RIMS3) which interacts with voltage-dependent Ca 2+ channels and regulates neurotransmitter vesicle anchoring xref ; and (5) NSF and NAPA(SNAP-α) which bind and then dissociate SNARE complexes for synaptic vesicle recycling xref ."
22558445
QMPSF affects CACNA1A
| 1
QMPSF activates CACNA1A. 1 / 1
| 1
reach
"MLPA and QMPSF allowed inspection of 40 out of 48 CACNA1A exons."
28566750
Prx-I affects CACNA1A
| 1
Prx-I inhibits CACNA1A. 1 / 1
| 1
reach
"The BI-TK and GCV treatment system exhibited a sustainable anti-tumor growth activity and induced apoptosis in bladder cancer tissues by inhibition of Prx-I through the NF-kappaB pathway."
24904997
Porins affects CACNA1A
| 1
Porins binds CACNA1A. 1 / 1
| 1
sparser
"The voltage dependent anionic channels (VDACs) also known as mitochondrial porins form channels in the outer mitochondrial membranes and act as primary pathway for the movement of metabolites across the outer membrane [ xref , xref , xref – xref ]."
24260034
Phe-Asp affects CACNA1A
| 1
Phe-Asp inhibits CACNA1A. 1 / 1
| 1
reach
"Synaptic transmission (SyT) (XREF_FIG, XREF_TABLE) was a highly significant sub-family of nervous system development and function (34 molecules, 23.3% of parent function; p = 4.9 x10 -7) sharing 10 common genes with Ngs (CNR1, SHC3, NLGN1, ADRB2, CACNA1A, CNP, and MPZ were elevated and TNF, FGF2, and IL1B were suppressed by FD)."
24632812
Pb-texaphyrin affects CACNA1A
| 1
CACNA1A binds Pb-texaphyrin. 1 / 1
| 1
reach
"The chemical structures of the target Bi- and Pb-texaphyrin complexes are shown in XREF_FIG."
20922235
PTGDS affects CACNA1A
1 |
CACNA1A binds PTGDS. 1 / 1
1 |
biogrid
No evidence text available
21078624
PRRT2 affects CACNA1A
| 1
CACNA1A binds PRRT2. 1 / 1
| 1
sparser
"Mutations in the CACNA1A and PRRT2 genes, which are associated with FHM, have been found in some patients with benign paroxysmal torticollis and benign paroxysmal vertigo [ xref , xref ], thus confirming their link to migraine."
25928129
PRKCA affects CACNA1A
| 1
CACNA1A binds PRKCA. 1 / 1
| 1
sparser
"Although we provide evidence for a lack of interaction between PKCα and CaV2.1 in RBCs, further studies are required to decipher the signalling relationship between LPA, PKCα and CaV2.1."
23817128
PRF1 affects CACNA1A
| 1
PRF1 activates CACNA1A. 1 / 1
| 1
reach
"As shown in XREF_FIG, P1 stimulation enhanced the catalytic activity of eNOS that was abolished or blocked by pretreatment of cells with L-NAME or GO, respectively (panels A-i and B-i)."
26537637
PPP1R12C affects CACNA1A
1 |
CACNA1A binds PPP1R12C. 1 / 1
1 |
biogrid
No evidence text available
21078624
PPM1A affects CACNA1A
1 |
CACNA1A binds PPM1A. 1 / 1
1 |
hprd
No evidence text available
15728831
PPIG affects CACNA1A
1 |
CACNA1A binds PPIG. 1 / 1
1 |
biogrid
No evidence text available
21078624
PMM1 affects CACNA1A
1 |
CACNA1A binds PMM1. 1 / 1
1 |
biogrid
No evidence text available
21078624
PKA affects CACNA1A
| 1
PKA phosphorylates CACNA1A. 1 / 1
| 1
sparser
"For example, in cardiac muscles, PKA phosphorylates the ryanodine receptor and the L-type calcium channel to regulate heart beating xref , xref ."
24086161
PCSK6 affects CACNA1A
1 |
CACNA1A binds PCSK6. 1 / 1
1 |
biogrid
No evidence text available
21078624
PCSK5 affects CACNA1A
1 |
CACNA1A binds PCSK5. 1 / 1
1 |
biogrid
No evidence text available
21078624
PAX4 affects CACNA1A
| 1
PAX4 increases the amount of CACNA1A. 1 / 1
| 1
reach
"Pax4 was found to potentiate the expression of CACNA1A, induce a transient increase in CACNA1D and enhanced CACNA1C mRNA at all time points."
18335054
OLIG1 affects CACNA1A
1 |
CACNA1A binds OLIG1. 1 / 1
1 |
biogrid
No evidence text available
21078624
Nrt affects CACNA1A
| 1
CACNA1A binds Nrt. 1 / 1
| 1
sparser
"As noted above, the strength of synaptic inhibition arising from nRT neurons interacts with intrinsic voltage-dependent conductances to control the timing of post-inhibitory rebound bursts, and thus the period and synchrony of thalamus-dependent oscillations, which prevail in the unconscious brain (Huguenard & McCormick, xref )."
24773078
NaPi-IIa affects CACNA1A
| 1
CACNA1A binds NaPi-IIa. 1 / 1
| 1
sparser
"The proposed interactions of the modified sites with the voltage-dependent parts of NaPi-IIa reveal a novel structure–function relationship; functionally, they result in modified steady-state cotransport kinetics that correlate with changes to the presteady-state kinetics."
15504899
NOXA1 affects CACNA1A
1 |
NOXA1 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
NOTCH1 affects CACNA1A
1 |
CACNA1A binds NOTCH1. 1 / 1
1 |
biogrid
No evidence text available
21078624
NF2 affects CACNA1A
| 1
NF2 inhibits CACNA1A. 1 / 1
| 1
reach
"Notably in AC, the matrix metallopeptidases, MMP1, MMP2 and MMP10 and the ion channels, CACNA1A and TRPV2, and in SC, the G protein coupled receptors GPR37 and NTSR1, are among the genes most highly upregulated by loss of merlin."
29897904
NELL2 affects CACNA1A
1 |
CACNA1A binds NELL2. 1 / 1
1 |
biogrid
No evidence text available
21078624
NELL1 affects CACNA1A
1 |
CACNA1A binds NELL1. 1 / 1
1 |
biogrid
No evidence text available
21078624
NELFCD affects CACNA1A
1 |
CACNA1A binds NELFCD. 1 / 1
1 |
biogrid
No evidence text available
21078624
NDUFB8 affects CACNA1A
1 |
CACNA1A binds NDUFB8. 1 / 1
1 |
biogrid
No evidence text available
21078624
NCIT:C48966 affects CACNA1A
| 1
CACNA1A binds NCIT:C48966. 1 / 1
| 1
sparser
"Recent studies suggested that autoantibodies that bind to voltage-dependent calcium channels and activate calcium entry may play a role in the progressive degeneration of motoneurons in sporadic amyotrophic lateral sclerosis."
8957009
MYF5 affects CACNA1A
| 1
CACNA1A binds MYF5. 1 / 1
| 1
sparser
"Finally, the myogenic vasoconstriction of renal microvessels is mediated in part by voltage-dependent calcium channels, and the altered myogenic response may be associated with modified activity of voltage-dependent calcium channels."
8986920
MS affects CACNA1A
| 1
CACNA1A binds MS. 1 / 1
| 1
sparser
"Possibly these differences give rise to the membrane-pipette interactions that allow the voltage-dependent activation of MS channels in patches formed with borosilicate glass pipettes and not with soft glass pipettes."
10354436
MOAP1 affects CACNA1A
1 |
CACNA1A binds MOAP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
MIA3 affects CACNA1A
1 |
CACNA1A binds MIA3. 1 / 1
1 |
biogrid
No evidence text available
21078624
MEGF8 affects CACNA1A
1 |
CACNA1A binds MEGF8. 1 / 1
1 |
biogrid
No evidence text available
21078624
MEGF6 affects CACNA1A
1 |
CACNA1A binds MEGF6. 1 / 1
1 |
biogrid
No evidence text available
21078624
MATN2 affects CACNA1A
1 |
CACNA1A binds MATN2. 1 / 1
1 |
biogrid
No evidence text available
21078624
MATK affects CACNA1A
1 |
CACNA1A binds MATK. 1 / 1
1 |
biogrid
No evidence text available
21078624
MAP1B affects CACNA1A
1 |
CACNA1A binds MAP1B. 1 / 1
1 |
biogrid
No evidence text available
25483588
MANBAL affects CACNA1A
1 |
CACNA1A binds MANBAL. 1 / 1
1 |
biogrid
No evidence text available
21078624
LTBP4 affects CACNA1A
1 |
CACNA1A binds LTBP4. 1 / 1
1 |
biogrid
No evidence text available
21078624
LTBP3 affects CACNA1A
1 |
CACNA1A binds LTBP3. 1 / 1
1 |
biogrid
No evidence text available
21078624
LTBP1 affects CACNA1A
1 |
CACNA1A binds LTBP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
LRP1 affects CACNA1A
1 |
CACNA1A binds LRP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
LNPEP affects CACNA1A
| 1
CACNA1A binds LNPEP. 1 / 1
| 1
reach
"(b) Graphical analysis of the non specific I) NA binding of CAIL Complexes of CAP with 170 bI) nucleosomal I) NA were formed as described, at a CAP to DNA ratio of 17.0."
6319715
LLGL1 affects CACNA1A
1 |
CACNA1A binds LLGL1. 1 / 1
1 |
biogrid
No evidence text available
21078624
L2 affects CACNA1A
| 1
L2 inhibits CACNA1A. 1 / 1
| 1
sparser
"The voltage-dependent inhibition by S(−)-CPP (from now on simply called CPP) has been phenomenologically described as a “shift” of the p open (V) curve to more positive voltages ( xref ) but its mechanism remains so far unclear."
11432801
L-glutamine affects CACNA1A
| 1
L-glutamine activates CACNA1A. 1 / 1
| 1
reach
"It is caused by a pathological expansion of the polyglutamine encoding CAG repeat in the CACNA1A gene on chromosome 19 3 and it is 100% penetrant."
28539669
KIAA1191 affects CACNA1A
1 |
CACNA1A binds KIAA1191. 1 / 1
1 |
biogrid
No evidence text available
21078624
KHDRBS3 affects CACNA1A
1 |
CACNA1A binds KHDRBS3. 1 / 1
1 |
biogrid
No evidence text available
21078624
KDM5B affects CACNA1A
1 |
CACNA1A binds KDM5B. 1 / 1
1 |
biogrid
No evidence text available
19336002
KALRN affects CACNA1A
1 |
CACNA1A binds KALRN. 1 / 1
1 |
biogrid
No evidence text available
21078624
JAG2 affects CACNA1A
1 |
CACNA1A binds JAG2. 1 / 1
1 |
biogrid
No evidence text available
21078624
IP6K1 affects CACNA1A
1 |
CACNA1A binds IP6K1. 1 / 1
1 |
biogrid
No evidence text available
21078624
INA affects CACNA1A
| 1
CACNA1A binds INA. 1 / 1
| 1
sparser
"The voltage-dependent inhibition of INa was associated with the shift of the INa availability curve to more negative potentials."
7528932
IL2 affects CACNA1A
| 1
CACNA1A binds IL2. 1 / 1
| 1
sparser
"In the present study, we examined the interaction between recombinant human interleukin-2 (rhIL-2) and the voltage-dependent calcium (Ca2+) current using the whole-cell patch-clamp technique."
8390310
IFIH1 affects CACNA1A
| 1
CACNA1A binds IFIH1. 1 / 1
| 1
reach
"Immunoblotting showed that MDA-5 bound specifically to Bio-C-IU (bI), but not Bio-C (bC) or C dsRNAs (XREF_FIG; compare lane 4 with lanes 5 and 6)."
20694008
IFI44 affects CACNA1A
| 1
CACNA1A binds IFI44. 1 / 1
| 1
sparser
"However, P44 was able to form voltage-dependent channels in phospholipid planar bilayers."
2422387
His-Met affects CACNA1A
| 1
His-Met binds CACNA1A. 1 / 1
| 1
reach
"Patient We report a 16-year clinical and neuroradiological follow-up of a patient carrying a de novo p.Ser218Leu CACNA1A HM mutation who had nine severe HM attacks associated with seizures and decreased consciousness between the ages of 3 and 12 years."
28750589
Hemagglutinins affects CACNA1A
| 1
CACNA1A binds Hemagglutinins. 1 / 1
| 1
sparser
"Here, we show that HA binds to the voltage-dependent Ca 2+ channel Ca v 1.2 to trigger intracellular Ca 2+ oscillations and subsequent IAV entry and replication."
29779930
HSPG2 affects CACNA1A
1 |
CACNA1A binds HSPG2. 1 / 1
1 |
biogrid
No evidence text available
21078624
HIVEP1 affects CACNA1A
1 |
CACNA1A binds HIVEP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
HHATL affects CACNA1A
1 |
HHATL binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
HECW1 affects CACNA1A
1 |
CACNA1A binds HECW1. 1 / 1
1 |
biogrid
No evidence text available
21078624
HC affects CACNA1A
| 1
HC activates CACNA1A. 1 / 1
| 1
sparser
"We conclude that (a) functional Cx43 HCs are present in ventricular cardiomyocytes, (b) when [Ca 2+ ] i is moderately elevated, these channels open at V m = + 40 mV, and (c) CxMPs prevent Ca 2+ and voltage-dependent HC activation."
23095853
GsMTx4 affects CACNA1A
| 1
GsMTx4 inhibits CACNA1A. 1 / 1
| 1
sparser
"It has electrophysiological properties similar to many endogenous cationic mechanosensitive ion channels (MSCs), with a reversal potential around 0 mV, voltage-dependent inactivation, and inhibition by the peptide GsMTx4 ( 6,7 )."
23972840
GRN affects CACNA1A
1 |
CACNA1A binds GRN. 1 / 1
1 |
biogrid
No evidence text available
21078624
GRM1 affects CACNA1A
| 1
CACNA1A binds GRM1. 1 / 1
| 1
sparser
"These data suggest that the assembly of mGluR1 and Cav2.1 provides the mechanism that ensures spatiotemporal regulation of [Ca2+]i in glutamatergic neurotransmission."
12704197
GOLGA6L5P affects CACNA1A
1 |
CACNA1A binds GOLGA6L5P. 1 / 1
1 |
biogrid
No evidence text available
21078624
GNB2 affects CACNA1A
1 |
CACNA1A binds GNB2. 1 / 1
1 |
biogrid
No evidence text available
9238069
GK affects CACNA1A
| 1
CACNA1A binds GK. 1 / 1
| 1
sparser
"YH-GKA also increased interaction between GK and voltage-dependent anion-selective channel protein."
24056026
GJB1 affects CACNA1A
| 1
CACNA1A binds GJB1. 1 / 1
| 1
sparser
"In this paper we present an approach to testing for the presence of a PK motif and evaluating its potential functional role in voltage-dependent gating of gap junctions formed by Cx32 by exploring structure-function relations in a series of constructs in which the proline kink has been modified by mutations."
10354417
GJA1 affects CACNA1A
| 1
CACNA1A binds GJA1. 1 / 1
| 1
sparser
"This may be partially associated with a reduction in cardiac expression of the voltage-dependent K + channel proteins (KCNA2 and KCNA5) and the gap junction protein CX43."
23791978
GET3 affects CACNA1A
1 |
CACNA1A binds GET3. 1 / 1
1 |
biogrid
No evidence text available
21078624
GALNT2 affects CACNA1A
| 1
GALNT2 glycosylates CACNA1A. 1 / 1
| 1
sparser
"In support of this finding, both GALNT1 and GALNT2 can glycosylate EA2 peptide, but only GALNT2 can glycosylate Apo C-III peptide [ xref ]."
25730904
GALNT1 affects CACNA1A
| 1
GALNT1 glycosylates CACNA1A. 1 / 1
| 1
sparser
"In support of this finding, both GALNT1 and GALNT2 can glycosylate EA2 peptide, but only GALNT2 can glycosylate Apo C-III peptide [ xref ]."
25730904
GABR affects CACNA1A
| 1
GABR binds CACNA1A. 1 / 1
| 1
sparser
"In mouse, one surprising finding is that NMDARs may be primed to open due to depolarization of the DSGC by acetylcholine receptor (AChR) activation in some stimulus conditions ( xref ). xref described a role for NMDARs in enhancing direction-selective signals: Local interactions between GABA receptors and voltage-dependent NMDARs lead to a balance between excitation and inhibition that aids DSGCs in maintaining directional tuning in noisy stimulus conditions."
28418757
FUT2 affects CACNA1A
| 1
FUT2 increases the amount of CACNA1A. 1 / 1
| 1
reach
"Maternal SE increased LC3A and B-I protein levels in the SE offspring (P = 0.03, F = 9.54, SE vs SHAM, Figure XREF_FIG)."
29018327
FGFR3 affects CACNA1A
| 1
CACNA1A binds FGFR3. 1 / 1
| 1
sparser
"The ACh response was associated with a voltage-dependent increase in membrane resistance which had a slow time course and appeared to be due to a turning off of an M current, as described by Brown and Adams (1980) in sympathetic ganglion cells."
6140079
FBLN1 affects CACNA1A
1 |
CACNA1A binds FBLN1. 1 / 1
1 |
biogrid
No evidence text available
21078624
FAAP20 affects CACNA1A
| 1
CACNA1A binds FAAP20. 1 / 1
| 1
sparser
"This voltage-dependent interaction of mAChRs with the secretory core complex appears suitable for controlling the rapid, synchronous neurotransmitter release at nerve terminals."
9365901
EIF3A affects CACNA1A
1 |
CACNA1A binds EIF3A. 1 / 1
1 |
biogrid
No evidence text available
21078624
EHMT2 affects CACNA1A
1 |
CACNA1A binds EHMT2. 1 / 1
1 |
biogrid
No evidence text available
21078624
EFEMP2 affects CACNA1A
1 |
CACNA1A binds EFEMP2. 1 / 1
1 |
biogrid
No evidence text available
21078624
EFEMP1 affects CACNA1A
1 |
CACNA1A binds EFEMP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
EDN1 affects CACNA1A
| 1
EDN1 activates CACNA1A. 1 / 1
| 1
sparser
"Ua might inhibit a calcium channel activated by ET-1 and PTH, in addition to blocking PLC."
7803518
DNAJB5 affects CACNA1A
1 |
CACNA1A binds DNAJB5. 1 / 1
1 |
biogrid
No evidence text available
21078624
CYSRT1 affects CACNA1A
1 |
CACNA1A binds CYSRT1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CYP71BL1 affects CACNA1A
| 1
CYP71BL1 activates CACNA1A. 1 / 1
| 1
reach
"Basically, basilar invagination pathophysiologic consequence was mainly induced by C1-2 articulation than occiput-C1 XREF_BIBR."
24294449
CYBA affects CACNA1A
| 1
CYBA hydroxylates CACNA1A. 1 / 1
| 1
sparser
"Isolation of DNA and quantitation of DNA by UV spectrophotometry were G. Qin et al. / Cancer Letters 112 (1997) 149-154 15) Table I Effect of GT pretreatment ot rats on hepatic microsomal cytochrome P-450 content and cytochrome P-450-mediated hydroxylations of AFB| and AFB] binding to exogenous DNA'1 Exp. no."
9066721
CTF affects CACNA1A
| 1
CACNA1A binds CTF. 1 / 1
| 1
sparser
"We conclude that SCA6 pathogenesis may be associated with the CTF, normally found in the cytoplasm, being aggregated in the cytoplasm and additionally distributed in the nucleus."
20043227
CRMP1 affects CACNA1A
1 |
CACNA1A binds CRMP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CRIM1 affects CACNA1A
1 |
CACNA1A binds CRIM1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CREB affects CACNA1A
| 1
CREB phosphorylates CACNA1A. 1 / 1
| 1
rlimsp
"Using Rat1 cells stably transfected with each of the three cloned human alpha1 adrenergic receptor subtypes, norepinephrine strongly stimulated CREB phosphorylation in alpha1A and alpha1B but more weakly in alpha1D-transfected cells."
9792725
COL18A1 affects CACNA1A
| 1
CACNA1A binds COL18A1. 1 / 1
| 1
sparser
"One possibility is that the interaction of Endostatin with the presynaptic CaV2.1 channels enables the channels to respond to low-voltage modulation."
25066085
CNR1 affects CACNA1A
| 1
CACNA1A binds CNR1. 1 / 1
| 1
sparser
"Moreover, CB 1 negatively binds certain Ca 2+ voltage dependent channels, induces G-protein-coupled modulating K + channels (GIRK), and subsequently inhibits neurotransmitter release independently of cAMP [ xref ]."
31653030
CKAP5 affects CACNA1A
1 |
CACNA1A binds CKAP5. 1 / 1
1 |
biogrid
No evidence text available
21078624
CGH affects CACNA1A
| 1
CGH inhibits CACNA1A. 1 / 1
| 1
reach
"The array CGH revealed candidate pathogenic copy number variations in four cases (22%, 4/18), including an Xq28 duplication, a 16p11.2 deletion, a 16p13.1 deletion and a 19p13.2 deletion disrupting CACNA1A."
25877686
CD38 affects CACNA1A
| 1
CACNA1A binds CD38. 1 / 1
| 1
sparser
"The PBMCs stored in liquid nitrogen was thawed in 37ºC before being stained with a mixture of fluorescence-labeled monoclonal antibodies for various surface makers (IgD-FITC, CD19-ECD, CD27-PC7, CD38-APCA750, IgM-PB, and CD45-KO; Beckman Coulter) to distinguish plasmablasts (IgD -IgM -CD27 + CD38 high ) and memory (IgD -IgM -CD27 + CD38 low ) B cell subpopulations."
28614803
CCL28 affects CACNA1A
| 1
CACNA1A binds CCL28. 1 / 1
| 1
sparser
"We have shown that the divalent ions Ca 2+ and Mg 2+ block channels formed by the MEC-4 complex in a voltage-dependent manner."
18504316
CALM3 affects CACNA1A
1 |
CACNA1A binds CALM3. 1 / 1
1 |
biogrid
No evidence text available
21078624
CALM2 affects CACNA1A
1 |
CACNA1A binds CALM2. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects vs
| 1
CACNA1A binds vs. 1 / 1
| 1
sparser
"We identified specific interactions between the PAS, CNBHD, and VS that modulate voltage-dependent gating and provide evidence that VS movement destabilizes these interactions to promote channel opening."
31490124
CACNA1A affects voltage-gated P
| 1
CACNA1A activates voltage-gated P. 1 / 1
| 1
eidos
"Surprisingly , a recent study reported that CaV2.1 , which mediates voltage-gated P / Q-type Ca2 + currents at cerebellar terminal synapses and is encoded by the CACNA1A gene [ 183 ] , is also localized to the lysosomes in mouse cultured granule cells [ 184 ] ."
30591696
CACNA1A affects unc-2 mutant
| 1
CACNA1A inhibits unc-2 mutant. 1 / 1
| 1
reach
"The evolutionary and functional relationship between the UNC-2 channel and the migraine associated CACNA1A channel was further confirmed through experiments showing that transgenic expression of human CACNA1A can suppress the lethargic and serotonin deficient phenotypes of unc-2 mutant animals."
16927961
CACNA1A affects translocator
| 1
CACNA1A binds translocator. 1 / 1
| 1
sparser
"It has been proposed that the mPTP is formed through conformational change in the association of the adenine nucleotide translocator (ANT) with the voltage dependent anion channel (VDAC) contact sites between the inner and outer mitochondrial membranes [ xref , xref ]."
22482055
CACNA1A affects translocation
| 1
CACNA1A inhibits translocation. 1 / 1
| 1
sparser
"Likewise (and as previously demonstrated for drug transport by Mdr1 and Mdr3), NBD-PC translocation by Mdr2 was inhibited by the calcium channel blocker and known P-gp modulator (Yusa and Tsuruo,1989) verapamil A 40 y 30 p E zd 40- pVT 20 10 D E F G H A B C mdr2 U '@b a."
7912658
CACNA1A affects tmd
| 1
CACNA1A binds tmd. 1 / 1
| 1
sparser
"Zn 2+ inhibits GluN2A with a high affinity by binding with NTD, and inhibits other GluN2 subunit containing NMDA receptors by binding only with the voltage dependent low affinity binding site at the TMD."
28536523
CACNA1A affects thymidine
| 1
CACNA1A activates thymidine. 1 / 1
| 1
reach
"The EGFr kinase inhibitor PD0158780 had relatively modest effects on fetal bovine serum stimulated thymidine incorporation as well as on EGF stimulated thymidine incorporation.A full concentration range of each of the three compounds was examined in NIH 3T3 cells and is shown in Fig. 6, B-I."
10974196
CACNA1A affects tellurium atom
| 1
Tellurium atom binds CACNA1A. 1 / 1
| 1
reach
"They further noted that neuron related genes such as GPM6A, SYT4, GRIK1, LPP9, and CACNA1A were significantly associated with TE; cell signaling genes, AKAP11, PTPN2, and NRP2 were associated with SE; and that 17 other genes, including ZFP42, CDH22, ALDH1A2, OTX2, and EN2 were associated with SY."
30376909
CACNA1A affects synaptotagmin, and syntaxin
| 1
CACNA1A binds synaptotagmin and syntaxin. 1 / 1
| 1
sparser
"Leveque C., El Far O., Martin-Moutot N. et al. Purification of the N-type calcium channel associated with syntaxin and synaptotagmin."
8889208
CACNA1A affects symporter activity
| 1
Symporter activity binds CACNA1A. 1 / 1
| 1
sparser
"Further insight into the interaction of protons with the voltage-dependent kinetics of type II Na/P cotransporters is reflected in the time course and magnitude of pre-steady-state relaxations induced by voltage steps ()."
10866949
CACNA1A affects signalling
| 1
CACNA1A inhibits signalling. 1 / 1
| 1
sparser
"Because TLR2 is another important receptor for DAMPs in the ischemic brain xref and other studies have shown that RANKL inhibited the TLR2 signal xref xref , we further investigated whether MHP1 could inhibit TLR2-stimulated signalling in MG6 cells."
27897273
CACNA1A affects ryanodine receptor
| 1
CACNA1A binds ryanodine receptor. 1 / 1
| 1
sparser
"This occurs when the Ryanodine receptor (RyR1) on the sarcoplasmic reticular (SR) membrane interacts with voltage-dependent Ca 2+ channels on the T-tubules such as dyhydropyridine receptors (DHPRs) and allows calcium release from the SR into the sarcoplasm when activated xref ."
24270550
CACNA1A affects pstS
| 1
CACNA1A binds pstS. 1 / 1
| 1
sparser
"Interaction of charged and uncharged calcium channel antagonists with phos- pholipid memhranes."
7760349
CACNA1A affects process
| 1
CACNA1A inhibits process. 1 / 1
| 1
sparser
"Moreover, the classical 'anode-break' stimulation from - 50/- 60 mV uncovered isolated low-threshold spikes, indicating a time- and voltage-dependent de-inactivating process."
12106316
CACNA1A affects porcine elastase
| 1
CACNA1A inhibits porcine elastase. 1 / 1
| 1
reach
"B-I (BII) inactivated bovine alpha-chymotrypsin and porcine elastase."
528539
CACNA1A affects phencyclidine
| 1
Phencyclidine binds CACNA1A. 1 / 1
| 1
sparser
"Ketamine is a dissociative anaesthetic drug which has been shown to bind selectively to the PCP recognition site in the NMDA receptor-gated calcium channel (Lodge and Johnsson, 1990; 0ye et al., 1992)."
9234346
CACNA1A affects pepA
| 1
CACNA1A binds pepA. 1 / 1
| 1
sparser
"AmpA forms voltage-dependent ion conducting pores in eggPC planar bilayers [ xref ], the hydrophobic core thickness of which has been estimated to be 26 Å by others [ xref ]."
21403824
CACNA1A affects pcs
| 1
CACNA1A binds pcs. 1 / 1
| 1
sparser
"Atypical slow CF responses of GluRdelta2 mutant PCs were associated with voltage-dependent Ca(2+) signals that were confined to PC distal dendrites."
11739579
CACNA1A affects neurite outgrowth
| 1
CACNA1A inhibits neurite outgrowth. 1 / 1
| 1
sparser
"Depletion of HPCA inhibited both neurite outgrowth and synaptophysin (SYP) expression, whereas overexpression of HPCA enhanced neuronal differentiation."
31486848
CACNA1A affects migration
| 1
CACNA1A inhibits migration. 1 / 1
| 1
sparser
"In the Boyden chamber assay, gelatin zymography, and subsequent immunoblotting assay, the combination Bi and Dox inhibited migration, possibly through downregulation of MMP9, MMP2, HER2, Rac1, and p120 protein expression."
30276148
CACNA1A affects lysosomal
| 1
CACNA1A activates lysosomal. 1 / 1
| 1
reach
"Given that the primary role of a VGCC is its calcium channel activity and that a mis sense mutation in the calcium ion selectivity pore in the fly homolog of Cacna1a causes lysosomal fusion defects similar to the loss of the gene, CACNA1A likely regulates lysosomal fusion through its calcium channel activity."
25811491
CACNA1A affects lactate
| 1
CACNA1A activates lactate. 1 / 1
| 1
reach
"Infantis produced more acetate and lactate, in concordance with the ability Bi."
28976925
CACNA1A affects kcsA
| 1
CACNA1A binds kcsA. 1 / 1
| 1
sparser
"Voltage-dependent Interactions of Na + Ions with KcsA."
12198089
CACNA1A affects inflammatory response
| 1
CACNA1A inhibits inflammatory response. 1 / 1
| 1
sparser
"To check whether MHP1 could inhibit inflammation and microglia activation, we examined the number of F4/80 positive cells in the ischemic region and the expression of IL-6 and MCP-1 mRNA at 48 hours after the treatment."
30151382
CACNA1A affects homeostatic process
| 1
CACNA1A activates homeostatic process. 1 / 1
| 1
reach
"The shared hemiplegic migraine phenotype of mutations in ATP1A2 and CACNA1A raises the possibility that they coordinately regulate ion homeostasis that determines susceptibility to the initiation of both migraine aura and the pain phase of migraine."
14624354
CACNA1A affects hemolysin
| 1
CACNA1A binds hemolysin. 1 / 1
| 1
sparser
"Menestrina, G. and Ropele, M. (1989) Voltage-dependent gating properties of the channel formed by E. coli hemolysin in planar lipid membranes."
8160187
CACNA1A affects hTMEM266
| 1
CACNA1A binds hTMEM266. 1 / 1
| 1
sparser
"HTMEM266 has been reported to localize on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum ( xref ), and having established that hTMEM266 is a functional voltage sensor it will be exciting to explore whether hTMEM266 can specifically interact with intracellular signaling pathways to provide voltage-dependent regulation."
30810529
CACNA1A affects exocytosis
| 1
CACNA1A inhibits exocytosis. 1 / 1
| 1
reach
"A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis."
20080591
CACNA1A affects episodic ataxia type II
| 1
CACNA1A activates episodic ataxia type II. 1 / 1
| 1
reach
"On the other hand, episodic ataxia type II is caused most often by the mutation in calcium channel gene CACNA1A, but potassium channel blocker - 4-amino pyridine, is one of the efficient treatment option [XREF_BIBR]."
23409712
CACNA1A affects episodic ataxia 2
| 1
CACNA1A activates episodic ataxia 2. 1 / 1
| 1
reach
"Mutations of KCNA1 and CACNA1A cause episodic ataxia 1 (EA1 : MIM # 160120) and episodic ataxia 2 (EA2 : MIM # 108500), respectively."
12736095
CACNA1A affects episodic ataxia 1
| 1
CACNA1A activates episodic ataxia 1. 1 / 1
| 1
reach
"Mutations of KCNA1 and CACNA1A cause episodic ataxia 1 (EA1 : MIM # 160120) and episodic ataxia 2 (EA2 : MIM # 108500), respectively."
12736095
CACNA1A affects episodic ataxia
| 1
CACNA1A activates episodic ataxia. 1 / 1
| 1
reach
"An example is mutations in the CACNA1A gene, which causes familial hemiplegic migraine (FHM-1), episodic ataxia (EA-2) or spinocerebellar ataxia (SCA-6) [XREF_BIBR, XREF_BIBR]."
20385006
CACNA1A affects effect
| 1
CACNA1A inhibits effect. 1 / 1
| 1
sparser
"hUII stimulated [(3)H]thymidine uptake into quiescent cells in a dose-dependent manner (10(-9) to 10(-7) M); this effect was inhibited by a protein kinase C inhibitor (GF109203X), a MAPK kinase inhibitor (PD98059), and a calcium channel blocker (nicardipine)."
12697688
CACNA1A affects dissemination infection household contacts
| 1
CACNA1A activates dissemination infection household contacts. 1 / 1
| 1
eidos
"LL and BL forms of leprosy together with positive BI contribute to dissemination of infection to the household contacts ."
32371193
CACNA1A affects dihydrogen
| 1
CACNA1A activates dihydrogen. 1 / 1
| 1
sparser
"In 2002, he held the position of lecturer in Biochemistry at the University of Bologna (Italy), and in 2003, he moved to UC Berkeley as a postdoctoral scholar, where he studied the mechanism of voltage-dependent activation of voltage-gated potassium and proton channels in the laboratory of Ehud Y. Isacoff."
29367199
CACNA1A affects conversion
| 1
CACNA1A inhibits conversion. 1 / 1
| 1
sparser
"Selective MAO-BIs may also inhibit the conversion of nontoxic xenobiotic substrates to neurotoxins in the brain, such as the MPTP conversion to its neurotoxic product MPP+."
27341283
CACNA1A affects conotoxin
| 1
CACNA1A binds conotoxin. 1 / 1
| 1
sparser
"Concentrations of (±)-AR-A008055 or either enantiomer up to a concentration of 1 mM failed to produce significant displacement of [ 3 H ] dizocilpine binding to the NMDA receptor, [ 3 H ] AMPA binding to the AMPA receptor, [ 125 I ] ω-conotoxin MVIIC binding to N or P/Q type calcium channels or [ 3 H ] batrachotoxin binding to the sodium channel."
11489453
CACNA1A affects coma
| 1
CACNA1A activates coma. 1 / 1
| 1
reach
"CACNA1A gene de novo mutation causing hemiplegic migraine, coma, and cerebellar atrophy."
11061267
CACNA1A affects chips
| 1
CACNA1A activates chips. 1 / 1
| 1
reach
"Consequently, the received signal during a chip interval can be written as : (30) R (omegat) = {Cej (bComegat+ phiC) + Iej (bI1omegat+ phiI) omegat = [0, phit] Cej (bComegat+ phiC) + Iej (bI2omegat+ d) omegat = (phit, pi/2] where b C defines the turning direction of the useful chip, while bI 1 and bI 2 are the turning directions of the sequential chips of the interferer."
24658624
CACNA1A affects calcium-binding
| 1
CACNA1A binds calcium-binding. 1 / 1
| 1
sparser
"CCMM animals present a decline of the density of Purkinje cells, with a diminished Cav2.1 activity associated with a decrease in the expression of calcium-binding proteins ( Dove et al ., 2000; Herrup and Wilczynski, 1982 )."
21907100
CACNA1A affects cadmium atom
| 1
CACNA1A inhibits cadmium atom. 1 / 1
| 1
sparser
"The present study illustrates that low concentrations of extracellular Cd 2+ modulated voltage-dependent HERG inactivation independently of channel activation."
10545354
CACNA1A affects bovine alpha-chymotrypsin
| 1
CACNA1A inhibits bovine alpha-chymotrypsin. 1 / 1
| 1
reach
"B-I (BII) inactivated bovine alpha-chymotrypsin and porcine elastase."
528539
CACNA1A affects botB
| 1
CACNA1A inhibits botB. 1 / 1
| 1
reach
"Buforin I was found not to be a substrate for BoNT/B; however, B-I dose dependently and competitively inhibited BoNT/B activity, yielding IC (50) = 1 x 10 (-6) M."
10594894
CACNA1A affects binding
| 1
CACNA1A inhibits binding. 1 / 1
| 1
sparser
"The receptor does not appear to be the classical ~2 receptor, but PAF binding is competitively inhibited by the ~2 antagonists phenoxybenzamine and phentolamine as well as the calcium channel blockers verapamil and nifedipine (3)."
3977920
CACNA1A affects bC
| 1
CACNA1A binds bC. 1 / 1
| 1
reach
"Therefore, the presence of F6 enhances the binding of b ', bI and bC to F, ~ OSCP, although F6 does not appear to form a strong direct interaction with the binary complex."
8206156
CACNA1A affects ataxia type 2
| 1
CACNA1A activates ataxia type 2. 1 / 1
| 1
reach
"Mutations in CACNA1A, which encodes the principal subunit of the P/Q calcium channel, underlie episodic ataxia type 2 (EA2)."
20156848
CACNA1A affects anxa3a
| 1
CACNA1A binds anxa3a. 1 / 1
| 1
sparser
"This paper describes for the first time the voltage dependent binding of annexins to membrane bilayers."
9408179
CACNA1A affects alpha1 subunit
| 1
CACNA1A activates alpha1 subunit. 1 / 1
| 1
reach
"The CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E and CACNA1G genes produce various isoform of alpha1 subunit including A, B, C, D, E and G, respectively."
24768178
CACNA1A affects activity
| 1
CACNA1A inhibits activity. 1 / 1
| 1
sparser
"Anthracycline antibiotics violamycin BI (VBI) and adriamycin (Adr) strongly inhibited the neuraminidase (NA) activity of Sendai virus and of its isolated glycoproteins, occurring either in solution or associated in liposome-like particles."
2869662
CACNA1A affects acetic acid
| 1
CACNA1A activates acetic acid. 1 / 1
| 1
reach
"Infantis produced more acetate and lactate, in concordance with the ability Bi."
28976925
CACNA1A affects acetazolamide(1-)
| 1
CACNA1A activates acetazolamide(1-). 1 / 1
| 1
reach
"De novo mutation in CACNA1A caused acetazolamide responsive episodic ataxia."
9600739
CACNA1A affects accumulation
| 1
CACNA1A inhibits accumulation. 1 / 1
| 1
sparser
"St and BI also inhibited the re-accumulation of NFATp in the cytoplasm and its re-phosphorylation after ionomycin removal."
9182723
CACNA1A affects ZNF233
1 |
CACNA1A binds ZNF233. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects ZCCHC17
1 |
CACNA1A binds ZCCHC17. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects WHAMM
| 1
CACNA1A binds WHAMM. 1 / 1
| 1
sparser
"The data obtained suggest that interactions of microtubules and voltage-dependent calcium channels by either direct or indirect mechanisms inhibit channel activities and decrease their half-life."
8804414
CACNA1A affects WBP1
1 |
WBP1 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects VWF
1 |
VWF binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects VSNA1
| 1
CACNA1A binds VSNA1. 1 / 1
| 1
sparser
"It was shown that the defensin forms voltage-dependent channels in the bacteria, and disrupts the permeability barrier of the cytoplasmic membrane of the bacteria, resulting in loss of cytoplasmic potassium, a partial depolarization of the inner membrane, a decrease in cytoplasmic ATP, and inhibition of respiration xref ."
23056609
CACNA1A affects VPS52
1 |
VPS52 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects VARS1
1 |
VARS1 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects UQCRC2
1 |
UQCRC2 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects UBE2L3
1 |
UBE2L3 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
25483588
CACNA1A affects Toll Like Receptor
| 1
CACNA1A inhibits Toll Like Receptor. 1 / 1
| 1
sparser
"Our previous report demonstrated that MHP1 significantly inhibits Toll-like receptor (TLR) 2- and 4-induced inflammation in microglia/macrophages through RANK signaling without osteoclast activation."
30151382
CACNA1A affects TYRP1
| 1
TYRP1 binds CACNA1A. 1 / 1
| 1
sparser
"This finding is in line with the observation that some indole metabolites of TRP (e.g., oxindole), demonstrate sedative properties; these sedative properties occur due to the interaction of these TRP metabolites with voltage-dependent Na+channels ( Carpenedo et al., 1998; Moroni, 1999 )."
26601775
CACNA1A affects TSPO
| 1
TSPO binds CACNA1A. 1 / 1
| 1
sparser
"A series of ACBD3 suppression and overexpression studies, along with expression of dominant negative mutants and in vitro reconstitution experiments in steroid synthesizing and control cells, support the idea that upon hormonal stimulation, the mitochondrial proteins TSPO and voltage-dependent anion-selective channel (VDAC) form a complex that allows for the recruitment and anchoring of ACBD3, PRKAR1A, ACBD1 and StAR on the surface of the mitochondria and subsequent cholesterol transfer [ xref , xref , xref , xref , xref , xref ]."
20043945
CACNA1A affects TSPAN7
1 |
TSPAN7 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects TSC22D1
1 |
CACNA1A binds TSC22D1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects TFS1
| 1
CACNA1A inhibits TFS1. 1 / 1
| 1
sparser
"TNF-α application also inhibited voltage-dependent inactivation of IC a,T, shifted the inactivation curve to the left."
27119319
CACNA1A affects TELO2
1 |
CACNA1A binds TELO2. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects TEA
| 1
CACNA1A binds TEA. 1 / 1
| 1
sparser
"Moreover, such a binding site for nystatin is likely to be different from that for TEA, which binds in a voltage-dependent manner to the inner mouth of the pore (; )."
8938720
CACNA1A affects TCTN3
1 |
CACNA1A binds TCTN3. 1 / 1
1 |
biogrid
No evidence text available
26638075
CACNA1A affects TCTN2
1 |
CACNA1A binds TCTN2. 1 / 1
1 |
biogrid
No evidence text available
26638075
CACNA1A affects TBPL1
| 1
CACNA1A activates TBPL1. 1 / 1
| 1
sparser
"The voltage-dependent activation of TRPs is sensitive to other triggers, such as the presence of ligands or changes in temperature that can alter the midpoint of the activation by several hundreds of millivolts [ xref , xref ]."
21401968
CACNA1A affects TAF15
1 |
TAF15 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects SYP
| 1
SYP binds CACNA1A. 1 / 1
| 1
sparser
"Indeed, reconstitution studies have suggested that synaptophysin forms voltage-dependent cation channels (Thomas et al., 1988), similar to cation channels found in patch-clamped fused synaptic vesicles from Torpedo (Rahamimoff et al., 1989)."
7507717
CACNA1A affects SUMF2
1 |
CACNA1A binds SUMF2. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects SST
| 1
SST binds CACNA1A. 1 / 1
| 1
sparser
"SST binding to the G-protein-coupled receptors (SSTR1-SSTR5) that are directly linked to voltage-dependent Ca 2+ channels inhibits Ca 2+ channel activity and associated downstream events."
27787949
CACNA1A affects SRSF1
1 |
SRSF1 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects SRRM4
1 |
CACNA1A binds SRRM4. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects SPRY1
1 |
SPRY1 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects SNAP25, and Voltage_gated_ion_channels
| 1
Voltage_gated_ion_channels binds SNAP25 and CACNA1A. 1 / 1
| 1
sparser
"Previous studies have shown that SNAP-25 is associated with N and P/Q type voltage gated calcium channels [for review, see ref. [ xref ]], and specifically impedes calcium currents through P/Q type channels activated in response to action potential-like stimuli [ xref ]."
18959796
CACNA1A affects SLC26A5, and Trypsin
| 1
Trypsin binds CACNA1A and SLC26A5. 1 / 1
| 1
sparser
"Because GFP alone did not bring about a voltage-dependent component in the membrane capacitance with or without intracellular trypsin treatment, the voltage-dependent component was associated with prestin."
14747354
CACNA1A affects SIGMAR1
| 1
CACNA1A binds SIGMAR1. 1 / 1
| 1
sparser
"This protein is involved in the transport of cholesterol from ER to mitochondria via interaction with the two mitochondria-associated membrane proteins sigma1 receptor and voltage-dependent anion-selective channel (VDAC) protein (Marriott et al. xref )."
27449929
CACNA1A affects SH3PXD2A
| 1
CACNA1A activates SH3PXD2A. 1 / 1
| 1
reach
"Importantly, the bath immersion model established in the present study also allows natural exposure of challenged fish to SAV3."
27068518
CACNA1A affects SERPINB14
| 1
CACNA1A activates SERPINB14. 1 / 1
| 1
reach
"REFERENCES Agrewala J. N., Vinay D. S., Joshi A. and Mishra G. C. (1994) A 150 kDa molecule of macrophage membrane stimulates interleukin-2 and interferon-gamma production and proliferation of ovalbumin specific CD4+ T cells."
8604218
CACNA1A affects SCP2
1 |
SCP2 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects SCA17
| 1
CACNA1A activates SCA17. 1 / 1
| 1
reach
"XREF_BIBR SCA1, SCA2, Machado-Joseph or SCA3, SCA6, SCA7, SCA12, SCA17, and dentatorubral-pallidoluysian atrophy (DRPLA) are caused by (CAG) n repeat expansions in the ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, PPP2R2B, TBP, and ATN1 genes, respectively, and all lead to the expansion of a polyglutamine tract in the corresponding proteins."
24780882
CACNA1A affects SCA12
| 1
CACNA1A activates SCA12. 1 / 1
| 1
reach
"XREF_BIBR SCA1, SCA2, Machado-Joseph or SCA3, SCA6, SCA7, SCA12, SCA17, and dentatorubral-pallidoluysian atrophy (DRPLA) are caused by (CAG) n repeat expansions in the ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, PPP2R2B, TBP, and ATN1 genes, respectively, and all lead to the expansion of a polyglutamine tract in the corresponding proteins."
24780882
CACNA1A affects SCA type 6
| 1
Mutated CACNA1A activates SCA type 6. 1 / 1
| 1
reach
"Different mutations of the CACNA1A genes, which encode the immunogenic alpha-1A VGCC subunit (Ca v 2.1), can produce the autosomal dominant SCA type 6, episodic ataxia type 2 (EA2) or familial hemiplegic migraine 1 (FHM1)."
26377184
CACNA1A affects SAG
| 1
CACNA1A binds SAG. 1 / 1
| 1
sparser
"The voltage-dependent activation of the conductance(s) responsible for this sag has commonly been associated with resonance properties."
24399930
CACNA1A affects RyR
| 1
CACNA1A inhibits RyR. 1 / 1
| 1
sparser
"Previous reports of voltage-dependent inactivation of RyR indicated that this was not a property of all RyR, but only a subgroup of channels ( Sitsapesan et al., 1995b ; Ma, 1995 ; Laver and Lamb, 1998 )."
12023226
CACNA1A affects Receptors, Antigen, B-Cell
| 1
CACNA1A activates Receptors, Antigen, B-Cell. 1 / 1
| 1
sparser
"Bi- and trivalent haptens activated the BCR, as measured by protein phosphorylation, Ca(2+) influx, BCR down-modulation and CD69, CD86 and MHC class II up-regulation."
20145007
CACNA1A affects RYR1, and SNCG
| 1
RYR1 binds SNCG and CACNA1A. 1 / 1
| 1
sparser
"The use of chimeric constructs of β1a [ xref ] with other β subunits, as well as the use of synthetic peptides [ xref ], allowed the identification of the C-terminal region of β1a as an important domain for possible interaction with RyR1 during TT voltage-dependent SR Ca 2+ release."
30025545
CACNA1A affects RYR
| 1
CACNA1A activates RYR. 1 / 1
| 1
sparser
"A similar voltage-dependent activation of RyRs underlies graded responses in skeletal muscle (Tsugorka et al., 1995)."
8521483
CACNA1A affects RPS17
1 |
RPS17 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects RPL31
1 |
RPL31 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects RME
| 1
CACNA1A activates RME. 1 / 1
| 1
reach
"Small fibrils of Abeta 1-42 are internalized in vitro by neonatal murine microglia, via RME mediated by scavenger receptors A class I and II (SRAs) and B-I (SRB-I)."
27421577
CACNA1A affects RIMS1, and vdcC
| 1
CACNA1A binds RIMS1 and vdcC. 1 / 1
| 1
sparser
"RIM1 associated with VDCC beta-subunits via its C terminus to markedly suppress voltage-dependent inactivation among different neuronal VDCCs."
17496890
CACNA1A affects RBBP8
| 1
CACNA1A binds RBBP8. 1 / 1
| 1
sparser
"These genes included: (1) 2 complexins (CPLX1 and CPLX2) and 3 synaptotagmins (SYT1, SYT2, and SYT3), which together regulate calcium-dependent exocytosis xref , xref ; (2) one of the synapsins (SYN2) which are involved in vesicle tethering and controlling the number of vesicles available for release xref ; (3) synaptophysin (SYP) which binds synaptobrevin (VAMP1) and plays a role in the control of exocytosis xref ; (4) one of the RIM family members (RIMS3) which interacts with voltage-dependent Ca 2+ channels and regulates neurotransmitter vesicle anchoring xref ; and (5) NSF and NAPA(SNAP-α) which bind and then dissociate SNARE complexes for synaptic vesicle recycling xref ."
22558445
CACNA1A affects Pb-texaphyrin
| 1
CACNA1A binds Pb-texaphyrin. 1 / 1
| 1
reach
"The chemical structures of the target Bi- and Pb-texaphyrin complexes are shown in XREF_FIG."
20922235
CACNA1A affects PTGDS
1 |
CACNA1A binds PTGDS. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects PRRT2
| 1
CACNA1A binds PRRT2. 1 / 1
| 1
sparser
"Mutations in the CACNA1A and PRRT2 genes, which are associated with FHM, have been found in some patients with benign paroxysmal torticollis and benign paroxysmal vertigo [ xref , xref ], thus confirming their link to migraine."
25928129
CACNA1A affects PRKCA
| 1
CACNA1A binds PRKCA. 1 / 1
| 1
sparser
"Although we provide evidence for a lack of interaction between PKCα and CaV2.1 in RBCs, further studies are required to decipher the signalling relationship between LPA, PKCα and CaV2.1."
23817128
CACNA1A affects PPP1R12C
1 |
CACNA1A binds PPP1R12C. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects PPM1A
1 |
CACNA1A binds PPM1A. 1 / 1
1 |
hprd
No evidence text available
15728831
CACNA1A affects PPIG
1 |
CACNA1A binds PPIG. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects PMM1
1 |
CACNA1A binds PMM1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects PLK3
| 1
CACNA1A inhibits PLK3. 1 / 1
| 1
sparser
"BI 2536 and BI 6727 potently inhibit PLK1 as well as PLK2 and PLK3, and the inhibitor‐induced G 2 /M arrest was followed by strong induction of apoptosis. xref In contrast, GSK461364 has selectivity for PLK1 compared with PLK2 and PLK3, and the high concentration of GSK461364 induces G 2 delay rather than mitotic arrest. xref Thus, pharmacological phenotypes of GSK461364 seem to be different from those of BI 2536 and BI 6727, especially regarding apoptosis‐inducing effects at higher concentrations."
27699933
CACNA1A affects PLK2
| 1
CACNA1A inhibits PLK2. 1 / 1
| 1
sparser
"BI 2536 and BI 6727 potently inhibit PLK1 as well as PLK2 and PLK3, and the inhibitor‐induced G 2 /M arrest was followed by strong induction of apoptosis. xref In contrast, GSK461364 has selectivity for PLK1 compared with PLK2 and PLK3, and the high concentration of GSK461364 induces G 2 delay rather than mitotic arrest. xref Thus, pharmacological phenotypes of GSK461364 seem to be different from those of BI 2536 and BI 6727, especially regarding apoptosis‐inducing effects at higher concentrations."
27699933
CACNA1A affects PLK1
| 1
CACNA1A inhibits PLK1. 1 / 1
| 1
sparser
"BI 2536 and BI 6727 potently inhibit PLK1 as well as PLK2 and PLK3, and the inhibitor‐induced G 2 /M arrest was followed by strong induction of apoptosis. xref In contrast, GSK461364 has selectivity for PLK1 compared with PLK2 and PLK3, and the high concentration of GSK461364 induces G 2 delay rather than mitotic arrest. xref Thus, pharmacological phenotypes of GSK461364 seem to be different from those of BI 2536 and BI 6727, especially regarding apoptosis‐inducing effects at higher concentrations."
27699933
CACNA1A affects PF-PC
| 1
CACNA1A activates PF-PC. 1 / 1
| 1
reach
"In GC-DeltaCACNA1A mice, the cell specific deletion of the CACNA1A gene minimizes the output of cerebellar granule cells and disrupts PF-PC plasticity (both LTP and LTD)."
27805050
CACNA1A affects PCSK6
1 |
CACNA1A binds PCSK6. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects PCSK5
1 |
CACNA1A binds PCSK5. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects PC
| 1
CACNA1A binds PC. 1 / 1
| 1
sparser
"Autocatalytic attachment of PCB to apo-SLA occurred ( xref ), which is similar to the reports that autocatalytic binding of PCB to ApcA may occur. xref This antocatalytic reaction was slow and incomplete and lyase was necessary for efficient attachment of PCB to SLA."
28448741
CACNA1A affects OLIG1
1 |
CACNA1A binds OLIG1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects Nrt
| 1
CACNA1A binds Nrt. 1 / 1
| 1
sparser
"As noted above, the strength of synaptic inhibition arising from nRT neurons interacts with intrinsic voltage-dependent conductances to control the timing of post-inhibitory rebound bursts, and thus the period and synchrony of thalamus-dependent oscillations, which prevail in the unconscious brain (Huguenard & McCormick, xref )."
24773078
CACNA1A affects NaPi-IIa
| 1
CACNA1A binds NaPi-IIa. 1 / 1
| 1
sparser
"The proposed interactions of the modified sites with the voltage-dependent parts of NaPi-IIa reveal a novel structure–function relationship; functionally, they result in modified steady-state cotransport kinetics that correlate with changes to the presteady-state kinetics."
15504899
CACNA1A affects NaChBac
| 1
CACNA1A activates NaChBac. 1 / 1
| 1
sparser
"Effect of isoflurane on NaChBac voltage-dependent activation."
28416648
CACNA1A affects NR3C2
| 1
CACNA1A activates NR3C2. 1 / 1
| 1
reach
"MK performed B/I activation of T cells, flow cytometry, MLR, and BrdU proliferation assays; MG performed flow cytometry; LG performed B/I activation of T cells; KG participated in study design; HDB participated in study design and manuscript preparation; FMM participated in study design and data analysis; MHM designed the experiments, analyzed data, and prepared the manuscript."
19849846
CACNA1A affects NR1I2, and mGluR
| 1
CACNA1A binds NR1I2 and mGluR. 1 / 1
| 1
sparser
"Immature synapses (postnatal days 1–2) exhibit a form of mGluR-dependent LTD that is induced postsynaptically via co-activation of group I mGluRs and voltage-dependent calcium channels, and expressed presynaptically at SCH-CA1 synapses in the hippocampus ( xref )."
22626985
CACNA1A affects NR0B1
| 1
Mutated CACNA1A activates NR0B1. 1 / 1
| 1
reach
"We provide the first evidence that a CACNA1A mutation can cause atypical AHC, indicating an overlap of molecular mechanisms causing AHC and FHM."
18498393
CACNA1A affects NOXA1
1 |
NOXA1 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects NOTCH1
1 |
CACNA1A binds NOTCH1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects NFkappaB
| 1
CACNA1A activates NFkappaB. 1 / 1
| 1
sparser
"In our experiments using RAW264.7 cells, RANKL activated NF-κB and NFATc1, whereas MHP1 did not activate NF-κB and NFATc1, but was able to inhibit TLR4-mediated cytokine production through RANK."
27897273
CACNA1A affects NFATC1
| 1
CACNA1A activates NFATC1. 1 / 1
| 1
sparser
"In our experiments using RAW264.7 cells, RANKL activated NF-κB and NFATc1, whereas MHP1 did not activate NF-κB and NFATc1, but was able to inhibit TLR4-mediated cytokine production through RANK."
27897273
CACNA1A affects NELL2
1 |
CACNA1A binds NELL2. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects NELL1
1 |
CACNA1A binds NELL1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects NELFCD
1 |
CACNA1A binds NELFCD. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects NDUFB8
1 |
CACNA1A binds NDUFB8. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects NCIT:C48966
| 1
CACNA1A binds NCIT:C48966. 1 / 1
| 1
sparser
"Recent studies suggested that autoantibodies that bind to voltage-dependent calcium channels and activate calcium entry may play a role in the progressive degeneration of motoneurons in sporadic amyotrophic lateral sclerosis."
8957009
CACNA1A affects Machado-Joseph
| 1
CACNA1A activates Machado-Joseph. 1 / 1
| 1
reach
"XREF_BIBR SCA1, SCA2, Machado-Joseph or SCA3, SCA6, SCA7, SCA12, SCA17, and dentatorubral-pallidoluysian atrophy (DRPLA) are caused by (CAG) n repeat expansions in the ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, PPP2R2B, TBP, and ATN1 genes, respectively, and all lead to the expansion of a polyglutamine tract in the corresponding proteins."
24780882
CACNA1A affects MYF5
| 1
CACNA1A binds MYF5. 1 / 1
| 1
sparser
"Finally, the myogenic vasoconstriction of renal microvessels is mediated in part by voltage-dependent calcium channels, and the altered myogenic response may be associated with modified activity of voltage-dependent calcium channels."
8986920
CACNA1A affects MTSS1
| 1
CACNA1A activates MTSS1. 1 / 1
| 1
reach
"Mutations of KCNA1 and CACNA1A cause episodic ataxia 1 (EA1 : MIM # 160120) and episodic ataxia 2 (EA2 : MIM # 108500), respectively."
12736095
CACNA1A affects MOAP1
1 |
CACNA1A binds MOAP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects MIA3
1 |
CACNA1A binds MIA3. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects MEGF8
1 |
CACNA1A binds MEGF8. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects MEGF6
1 |
CACNA1A binds MEGF6. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects MED36A
| 1
CACNA1A inhibits MED36A. 1 / 1
| 1
reach
"Loss-of-function clones of L using the bi-Gal4 driven FLP mediated recombination of FRT cassette on 2R resulted in selective loss of ventral eye (XREF_FIG)."
23109378
CACNA1A affects MCA-105
| 1
CACNA1A activates MCA-105. 1 / 1
| 1
reach
"In an intradermal tumor model, the adoptive transfer of B/I stimulated MCA-105 DLN cells cured mice of MCA-105 intradermal (id) tumors, but did not induce regression of MCA-206 tumors."
1528028
CACNA1A affects MATN2
1 |
CACNA1A binds MATN2. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects MATK
1 |
CACNA1A binds MATK. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects MAP1B
1 |
CACNA1A binds MAP1B. 1 / 1
1 |
biogrid
No evidence text available
25483588
CACNA1A affects MANBAL
1 |
CACNA1A binds MANBAL. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects Leu-Val
| 1
CACNA1A activates Leu-Val. 1 / 1
| 1
reach
"Balloon inflation (BI) in the proximal descending aorta increased LV PES from 100.7 +/- 13.4 to 140.2 +/- 19.3 mmHg (P less than 0.002) and LVEDV from 39.1 +/- 11.3 to 43.3 +/- 12.2 ml (P less than 0.01)."
2386232
CACNA1A affects LY6E
| 1
CACNA1A activates LY6E. 1 / 1
| 1
reach
"XREF_BIBR SCA1, SCA2, Machado-Joseph or SCA3, SCA6, SCA7, SCA12, SCA17, and dentatorubral-pallidoluysian atrophy (DRPLA) are caused by (CAG) n repeat expansions in the ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, PPP2R2B, TBP, and ATN1 genes, respectively, and all lead to the expansion of a polyglutamine tract in the corresponding proteins."
24780882
CACNA1A affects LTBP4
1 |
CACNA1A binds LTBP4. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects LTBP3
1 |
CACNA1A binds LTBP3. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects LTBP1
1 |
CACNA1A binds LTBP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects LRP1
1 |
CACNA1A binds LRP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects LNPEP
| 1
CACNA1A binds LNPEP. 1 / 1
| 1
reach
"(b) Graphical analysis of the non specific I) NA binding of CAIL Complexes of CAP with 170 bI) nucleosomal I) NA were formed as described, at a CAP to DNA ratio of 17.0."
6319715
CACNA1A affects LLGL1
1 |
CACNA1A binds LLGL1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects LC
| 1
CACNA1A inhibits LC. 1 / 1
| 1
sparser
"Effects of ethanol on voltage-dependent inactivation of lc,."
7720786
CACNA1A affects Kpnb1
| 1
CACNA1A inhibits Kpnb1. 1 / 1
| 1
sparser
"In conclusion, we have confirmed that N-type calcium channel activity in neonatal rat SCG neurons undergoes voltage-dependent G-protein–mediated inhibition."
10694257
CACNA1A affects KIAA1191
1 |
CACNA1A binds KIAA1191. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects KHDRBS3
1 |
CACNA1A binds KHDRBS3. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects KDM5B
1 |
CACNA1A binds KDM5B. 1 / 1
1 |
biogrid
No evidence text available
19336002
CACNA1A affects KCN, and NRPS3
| 1
KCN binds CACNA1A and NRPS3. 1 / 1
| 1
sparser
"In addition to the potential effect of polymorphisms in drug metabolizing enzymes, genetic polymorphisms in components of the L-type calcium channel ( CANC1C , CACN1D ) and the large-conductance calcium and voltage-dependent potassium channel ß1 subunit gene ( KCNMB1 ) are associated with responsiveness and risk of cardiovascular side effects in patients taking calcium channel blockers for hypertension xref – xref ."
25282474
CACNA1A affects KCN, and KCNA1
| 1
KCN binds CACNA1A and KCNA1. 1 / 1
| 1
sparser
"This manuscript showed that mutations in the voltage-dependent delayed rectifier potassium channel gene, KCNA1, associated with episodic ataxia cause loss, alteration and dominant-negative suppression of channel function."
8791523
CACNA1A affects KALRN
1 |
CACNA1A binds KALRN. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects JAG2
1 |
CACNA1A binds JAG2. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects IhERG
| 1
CACNA1A inhibits IhERG. 1 / 1
| 1
sparser
"Increasing [K(+)]e produced a +10 mV shift in voltage-dependent inactivation of WT IhERG and slowed inactivation time course, while lowering [K(+)]e from 4 to 1 mmol/L produced little change in inactivation voltage dependence, but accelerated inactivation time course."
25318749
CACNA1A affects IP6K1
1 |
CACNA1A binds IP6K1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects IL2RA
| 1
CACNA1A increases the amount of IL2RA. 1 / 1
| 1
reach
"The B/I activation, however, induced Foxp3 and CD25 expression in CD4+ and CD8+ T cells."
19849846
CACNA1A affects IGF2
| 1
CACNA1A leads to the phosphorylation of IGF2. 1 / 1
| 1
reach
"We found that siRNA mediated depletion of CACNA1D, but not CACNA1A, completely suppressed NNK induced IGF-1R phosphorylation and IGF2 secretion (XREF_FIG)."
27666821
CACNA1A affects IGF1R
| 1
CACNA1A leads to the phosphorylation of IGF1R. 1 / 1
| 1
reach
"We found that siRNA mediated depletion of CACNA1D, but not CACNA1A, completely suppressed NNK induced IGF-1R phosphorylation and IGF2 secretion (XREF_FIG)."
27666821
CACNA1A affects IFIH1
| 1
CACNA1A binds IFIH1. 1 / 1
| 1
reach
"Immunoblotting showed that MDA-5 bound specifically to Bio-C-IU (bI), but not Bio-C (bC) or C dsRNAs (XREF_FIG; compare lane 4 with lanes 5 and 6)."
20694008
CACNA1A affects IFI44
| 1
CACNA1A binds IFI44. 1 / 1
| 1
sparser
"However, P44 was able to form voltage-dependent channels in phospholipid planar bilayers."
2422387
CACNA1A affects Histone_H4
| 1
CACNA1A inhibits Histone_H4. 1 / 1
| 1
sparser
"Voltage-dependent inactivation of H4 was only partial and developed after the current activation threshold."
7875318
CACNA1A affects His-Met
| 1
His-Met binds CACNA1A. 1 / 1
| 1
reach
"Patient We report a 16-year clinical and neuroradiological follow-up of a patient carrying a de novo p.Ser218Leu CACNA1A HM mutation who had nine severe HM attacks associated with seizures and decreased consciousness between the ages of 3 and 12 years."
28750589
CACNA1A affects Hemagglutinins
| 1
CACNA1A binds Hemagglutinins. 1 / 1
| 1
sparser
"Here, we show that HA binds to the voltage-dependent Ca 2+ channel Ca v 1.2 to trigger intracellular Ca 2+ oscillations and subsequent IAV entry and replication."
29779930
CACNA1A affects HSPG2
1 |
CACNA1A binds HSPG2. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects HIVEP1
1 |
CACNA1A binds HIVEP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects HHATL
1 |
HHATL binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects HECW1
1 |
CACNA1A binds HECW1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects GYPA
| 1
CACNA1A inhibits GYPA. 1 / 1
| 1
sparser
"Together, our analysis revealed that SMA MNs display normal voltage dependent inactivation but faster recovery of Na + channels and suggest that SMN regulates AP pattern likely by modifying Na + -current activities."
26190808
CACNA1A affects GRN
1 |
CACNA1A binds GRN. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects GRM1
| 1
CACNA1A binds GRM1. 1 / 1
| 1
sparser
"These data suggest that the assembly of mGluR1 and Cav2.1 provides the mechanism that ensures spatiotemporal regulation of [Ca2+]i in glutamatergic neurotransmission."
12704197
CACNA1A affects GRIN2A, and GRM3
| 1
CACNA1A binds GRIN2A and GRM3. 1 / 1
| 1
sparser
"Interestingly, these loci have begun to implicate pathways: in addition to at least one target of current neuropharmacology (the dopamine receptor DRD2) , for the first time, critical glutamatergic genes such as GRM3 and GRIN2A, and calcium channel subunits ( CACNA1C and CACNA1l ) have been associated with SZ."
25520658
CACNA1A affects GPM6A, GRIK1, SYT4, and TE
| 1
SYT4 binds CACNA1A, GPM6A, GRIK1, and TE. 1 / 1
| 1
sparser
"They further noted that neuron-related genes such as GPM6A , SYT4 , GRIK1 , LPP9 , and CACNA1A were significantly associated with TE; cell-signaling genes, AKAP11, PTPN2 , and NRP2 were associated with SE; and that 17 other genes, including ZFP42 , CDH22 , ALDH1A2 , OTX2 , and EN2 were associated with SY."
30376909
CACNA1A affects GOLGA6L5P
1 |
CACNA1A binds GOLGA6L5P. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects GNB2
1 |
CACNA1A binds GNB2. 1 / 1
1 |
biogrid
No evidence text available
9238069
CACNA1A affects GK
| 1
CACNA1A binds GK. 1 / 1
| 1
sparser
"YH-GKA also increased interaction between GK and voltage-dependent anion-selective channel protein."
24056026
CACNA1A affects GJB1
| 1
CACNA1A binds GJB1. 1 / 1
| 1
sparser
"In this paper we present an approach to testing for the presence of a PK motif and evaluating its potential functional role in voltage-dependent gating of gap junctions formed by Cx32 by exploring structure-function relations in a series of constructs in which the proline kink has been modified by mutations."
10354417
CACNA1A affects GJA8
| 1
CACNA1A inhibits GJA8. 1 / 1
| 1
sparser
"Voltage-dependent inhibition of Cx50 channels by BQ + ."
22200948
CACNA1A affects GJA1
| 1
CACNA1A binds GJA1. 1 / 1
| 1
sparser
"This may be partially associated with a reduction in cardiac expression of the voltage-dependent K + channel proteins (KCNA2 and KCNA5) and the gap junction protein CX43."
23791978
CACNA1A affects GET3
1 |
CACNA1A binds GET3. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects GABR
| 1
GABR binds CACNA1A. 1 / 1
| 1
sparser
"In mouse, one surprising finding is that NMDARs may be primed to open due to depolarization of the DSGC by acetylcholine receptor (AChR) activation in some stimulus conditions ( xref ). xref described a role for NMDARs in enhancing direction-selective signals: Local interactions between GABA receptors and voltage-dependent NMDARs lead to a balance between excitation and inhibition that aids DSGCs in maintaining directional tuning in noisy stimulus conditions."
28418757
CACNA1A affects Familial Hemiplegic Migraine
| 1
CACNA1A activates Familial Hemiplegic Migraine. 1 / 1
| 1
reach
"Stroke like episodes (SLE) occur in phosphomannomutase deficiency (PMM2-CDG), and may complicate the course of channelopathies related to Familial Hemiplegic Migraine (FHM) caused by mutations in CACNA1A (encoding Ca V 2.1 channel)."
29470411
CACNA1A affects FOXP3
| 1
CACNA1A increases the amount of FOXP3. 1 / 1
| 1
reach
"The B/I activation, however, induced Foxp3 and CD25 expression in CD4+ and CD8+ T cells."
19849846
CACNA1A affects FOXH1, IK, and KCN
| 1
KCN binds CACNA1A, FOXH1, and IK. 1 / 1
| 1
sparser
"In Drosophila neurons the fast component of I K has been associated with the voltage-dependent potassium channel gene Shal ( Shaker cognate I ) ( xref ) and the voltage-dependent and calcium-activated potassium channel gene slowpoke ( slo ) ( xref )."
18305244
CACNA1A affects FHM-1
| 1
CACNA1A-R192Q activates FHM-1. 1 / 1
| 1
reach
"Transgenic knock-in mice expressing the CACNA1A R192Q mutation that causes FHM-1 in patients show a greater susceptibility to cortical spreading depression, the likely underlying mechanism of typical human migraine aura."
24355314
CACNA1A affects FHM Type 1
| 1
CACNA1A activates FHM Type 1. 1 / 1
| 1
reach
"FHM Type 1, which accounts for around 50% of all FHM cases, is caused by mutations in the CACNA1A gene encoding the Ca v 2.1 P/Q voltage dependent calcium channel."
27199775
CACNA1A affects FGFR3
| 1
CACNA1A binds FGFR3. 1 / 1
| 1
sparser
"The ACh response was associated with a voltage-dependent increase in membrane resistance which had a slow time course and appeared to be due to a turning off of an M current, as described by Brown and Adams (1980) in sympathetic ganglion cells."
6140079
CACNA1A affects FBLN1
1 |
CACNA1A binds FBLN1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects FAAP20
| 1
CACNA1A binds FAAP20. 1 / 1
| 1
sparser
"This voltage-dependent interaction of mAChRs with the secretory core complex appears suitable for controlling the rapid, synchronous neurotransmitter release at nerve terminals."
9365901
CACNA1A affects Episodic familial ataxia type 2
| 1
CACNA1A activates Episodic familial ataxia type 2. 1 / 1
| 1
reach
"Episodic familial ataxia type 2 is caused by mutations in the gene CACNA1A, in chromosome 19p, that codifies part of a calcium channel."
9859670
CACNA1A affects ERVK-18
| 1
CACNA1A activates ERVK-18. 1 / 1
| 1
reach
"However, our observation of equivalent frequencies of activated NK cells, CD3+ cells and Tm cells among reprogrammed PBMCs as well as PBMCs treated with gamma-c cytokines without B/I suggest that enrichment and differentiation of these cells is supported by gamma-c cytokines alone, but that total cellular expansion and increasing the absolute number of these cells is dependent on the activity of B/I."
24197563
CACNA1A affects ERC1, and INS
| 1
CACNA1A binds ERC1 and INS. 1 / 1
| 1
sparser
"ELKS forms a potent insulin secretion complex with L-type voltage-dependent Ca 2+ channels on the vascular-facing plasma membrane of β-cells, enabling polarized Ca 2+ influx and first-phase insulin secretion from islets."
31500835
CACNA1A affects ELK1
| 1
CACNA1A activates ELK1. 1 / 1
| 1
sparser
"Extracellular acidification inhibits voltage-dependent activation of mammalian Elk channels."
23712551
CACNA1A affects EIF4A2, and EIF4G3
| 1
CACNA1A binds EIF4A2 and EIF4G3. 1 / 1
| 1
sparser
"Ago4-bound miR-3191-5p blocked the interaction of eIF4AII and eIF4GII with the CACNA1A IRES, attenuating IRES-driven α1ACT translation."
27412786
CACNA1A affects EIF3A
1 |
CACNA1A binds EIF3A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects EHMT2
1 |
CACNA1A binds EHMT2. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects EFEMP2
1 |
CACNA1A binds EFEMP2. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects EFEMP1
1 |
CACNA1A binds EFEMP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects EA5
| 1
CACNA1A activates EA5. 1 / 1
| 1
reach
"CACNA1A and CACNB4 mutations lead to EA2 (MIM 108500) and EA5 (MIM 613855), respectively [XREF_BIBR, XREF_BIBR]."
26715324
CACNA1A affects EA2 [
| 1
CACNA1A activates EA2 [. 1 / 1
| 1
reach
"CACNA1A alternative splicing in the cerebellum of selected exons harboring nonsense mutations (such as exon 37A) can also cause EA2 [XREF_BIBR]."
22379397
CACNA1A affects DPYS
| 1
CACNA1A activates DPYS. 1 / 1
| 1
reach
"Discussion Distinct Neuronal Call Channel Subunits Comprise a Novel DHP Sensitive Subtype Our results demonstrate that the a, p subunit mediates DHP- sensitive, high voltage activated, long lasting Ca 2+ channel activity."
1309651
CACNA1A affects DNAJB5
1 |
CACNA1A binds DNAJB5. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects D15
| 1
CACNA1A activates D15. 1 / 1
| 1
reach
"Cacna1a, Cacna1g, Cacna1h, Cacna1i and Cacna2d1 mRNA expression behaved differently than Cacna1b since they were responsive to repeated METH induced D1/5 stimulation but were irresponsive to repeated SCH23390 alone treatment."
25871318
CACNA1A affects CngA
| 1
CACNA1A inhibits CngA. 1 / 1
| 1
sparser
"Unlike tetracaine, which elicits a voltage-dependent inhibition of CNG channels by binding within the pore of the channel, genistein inhibits the rod channel in a voltage-independent manner (Fig. xref B)."
9874687
CACNA1A affects Calcium_channels, and LTP
| 1
Calcium_channels binds CACNA1A and LTP. 1 / 1
| 1
sparser
"Last, a voltage-dependent calcium channel-dependent form of LTP in the CA1 could also be reversibly abated by LY294002, raising the possibility that PI3-kinase could be required for the expression of multiple forms of synaptic potentiation."
11978812
CACNA1A affects Calcium_channels, GTF2B, and Myosin_complex
| 1
Calcium_channels binds Myosin_complex, CACNA1A, and GTF2B. 1 / 1
| 1
sparser
"Ablation of myosin-IIB in mice is embryonic lethal, and myosin-IIB ( MYH10 ) mutations are thought to be embryonic lethal in humans, as well; however, myosin-IIB function has been associated with the pathogenesis of spinocerebellar ataxia type 6 (SCA6) through associations of myosin-IIB and Cav2.1 calcium channel polyglutamate tracts [ xref ]."
20850431
CACNA1A affects Calcium_channels, and GADD45A
| 1
Calcium_channels binds CACNA1A and GADD45A. 1 / 1
| 1
sparser
"Focal knockdown of growth arrest and DNA-damage-inducible protein 45β expression attenuated ligation-induced allodynia (n = 7) by reducing the binding of growth arrest and DNA-damage-inducible protein 45β to the voltage-dependent T-type calcium channel 3.2 subunit promoter (n = 6) that decreased expression of and current mediated by the voltage-dependent T-type calcium channel 3.2 subunit (both n = 6)."
28346321
CACNA1A affects CYSRT1
1 |
CACNA1A binds CYSRT1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects CTLA4, and IAPP
| 1
CACNA1A binds CTLA4 and IAPP. 1 / 1
| 1
sparser
"We report here that at cytotoxic concentrations, amylin forms voltage-dependent, relatively nonselective, ion-permeable channels in planar phospholipid bilayer membranes."
8567648
CACNA1A affects CTF
| 1
CACNA1A binds CTF. 1 / 1
| 1
sparser
"We conclude that SCA6 pathogenesis may be associated with the CTF, normally found in the cytoplasm, being aggregated in the cytoplasm and additionally distributed in the nucleus."
20043227
CACNA1A affects CRMP1
1 |
CACNA1A binds CRMP1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects CRIM1
1 |
CACNA1A binds CRIM1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects COL18A1
| 1
CACNA1A binds COL18A1. 1 / 1
| 1
sparser
"One possibility is that the interaction of Endostatin with the presynaptic CaV2.1 channels enables the channels to respond to low-voltage modulation."
25066085
CACNA1A affects CNR1
| 1
CACNA1A binds CNR1. 1 / 1
| 1
sparser
"Moreover, CB 1 negatively binds certain Ca 2+ voltage dependent channels, induces G-protein-coupled modulating K + channels (GIRK), and subsequently inhibits neurotransmitter release independently of cAMP [ xref ]."
31653030
CACNA1A affects CLTB
| 1
CACNA1A phosphorylates CLTB. 1 / 1
| 1
sparser
"Brockha~, M., Magnani,J+ L., k, M., Stepl~ski, Z., K i, H, Kar~n, K. A+, l~n, G. & Gi~burg, V. (1982) Mon~lonal ami~i di~ted a~ir.st the human Lcb bI p antigen+ 07."
6751531
CACNA1A affects CLCN2, Calcium_channels, DLL1, and TUBB3
| 1
Calcium_channels binds CACNA1A, CLCN2, TUBB3, and DLL1. 1 / 1
| 1
sparser
"Mutations of gamma-aminobutyric acid receptor alpha1, gamma-aminobutyric acid receptor delta, calcium channel voltage-dependent beta4 subunit and chloride channel 2 gene are associated with juvenile myoclonic epilepsy."
19298753
CACNA1A affects CLC
| 1
CACNA1A activates CLC. 1 / 1
| 1
sparser
"Two variants are located, also close to the interface, in the cystathionine-β-synthase domains, which have a role in the voltage-dependent activation of CLC channels xref and transporters. xref The previously reported de novo missense variant in family K (p."
27550844
CACNA1A affects CKAP5
1 |
CACNA1A binds CKAP5. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects CHRN
| 1
CACNA1A inhibits CHRN. 1 / 1
| 1
sparser
"PhTX-343 showed strongly voltage-dependent inhibition of heteromeric nAChRs, but it was voltage-independent for homomeric α7 ( xref )."
27901080
CACNA1A affects CHI3L1, TAC1, and α3
| 1
TAC1 binds CACNA1A, CHI3L1, and α3. 1 / 1
| 1
sparser
"The amylospheroids, amyloid β-protein (Aβ) oligomers typically found in postmortem brains of Alzheimer’s disease patients, can interact with α3-NKA impairing its activity, in turn leading to the activation of voltage-dependent calcium channels, mitochondrial abnormalities, and neurodegeneration ( xref ) (Figure xref )."
26909067
CACNA1A affects CH
| 1
CACNA1A activates CH. 1 / 1
| 1
reach
"CH in this family is not caused by mutations in the CACNA1A gene."
11843867
CACNA1A affects CFI, and HCN4
| 1
CACNA1A binds HCN4 and CFI. 1 / 1
| 1
sparser
"In response to stress-associated β-adrenergic stimulation, cyclic AMP (cAMP) is generated which binds directly to HCN4 and increases I f by shifted voltage-dependent activation."
28573409
CACNA1A affects CD8
| 1
CACNA1A activates CD8. 1 / 1
| 1
reach
"By immunohistochemistry, we had previously seen CD4 + and CD8 + T cells infiltrating tumors in mice treated with B/I activated lymphocytes [XREF_BIBR]."
21050466
CACNA1A affects CD69, and KN
| 1
CACNA1A binds CD69 and KN. 1 / 1
| 1
sparser
"Interestingly, SNP_1217, SNP_1472, SNP_1665, SNP_1753, SNP_1835, SNP_1896, and the only InDel (InDel_8) were associated with variation in both KN and KNPR in both EA1 and EA2."
31481842
CACNA1A affects CD62L - --> CD62L + )
| 1
CACNA1A activates CD62L - --> CD62L + ). 1 / 1
| 1
reach
"Unsorted B/I activated lymphocytes, CD62L + cells that remained CD62L + after B/I and expansion (CD62L + --> CD62L +), CD62L + cells that downregulated CD62L after B/I treatment and expansion (CD62L + --> CD62L -), CD62L - cells that remained CD62L - after B/I treatment and expansion (CD62L - --> CD62L -), or CD62L - cells that upregulated CD62L expression after B/I and expansion (CD62L - --> CD62L +) were infused into CYP pre-treated tumor bearing mice."
21050466
CACNA1A affects CD4+
| 1
CACNA1A activates CD4+. 1 / 1
| 1
reach
"REFERENCES Agrewala J. N., Vinay D. S., Joshi A. and Mishra G. C. (1994) A 150 kDa molecule of macrophage membrane stimulates interleukin-2 and interferon-gamma production and proliferation of ovalbumin specific CD4+ T cells."
8604218
CACNA1A affects CD4
| 1
CACNA1A activates CD4. 1 / 1
| 1
reach
"By immunohistochemistry, we had previously seen CD4 + and CD8 + T cells infiltrating tumors in mice treated with B/I activated lymphocytes [XREF_BIBR]."
21050466
CACNA1A affects CD38
| 1
CACNA1A binds CD38. 1 / 1
| 1
sparser
"The PBMCs stored in liquid nitrogen was thawed in 37ºC before being stained with a mixture of fluorescence-labeled monoclonal antibodies for various surface makers (IgD-FITC, CD19-ECD, CD27-PC7, CD38-APCA750, IgM-PB, and CD45-KO; Beckman Coulter) to distinguish plasmablasts (IgD -IgM -CD27 + CD38 high ) and memory (IgD -IgM -CD27 + CD38 low ) B cell subpopulations."
28614803
CACNA1A affects CCL28
| 1
CACNA1A binds CCL28. 1 / 1
| 1
sparser
"We have shown that the divalent ions Ca 2+ and Mg 2+ block channels formed by the MEC-4 complex in a voltage-dependent manner."
18504316
CACNA1A affects CC2D2A, Calcium_channels, GTF2B, and Myosin_complex
| 1
Calcium_channels binds Myosin_complex, CACNA1A, CC2D2A, and GTF2B. 1 / 1
| 1
sparser
"Ablation of myosin-IIB in mice is embryonic lethal, and myosin-IIB ( MYH10 ) mutations are thought to be embryonic lethal in humans, as well; however, myosin-IIB function has been associated with the pathogenesis of spinocerebellar ataxia type 6 (SCA6) through associations of myosin-IIB and Cav2.1 calcium channel polyglutamate tracts [ xref ]."
20850431
CACNA1A affects CAV3
| 1
CACNA1A inhibits CAV3. 1 / 1
| 1
sparser
"KCa1.1 channel activation was closely aligned with Cav3 calcium conductance in that KCa1.1 current shared the same low voltage dependence of Cav3 activation, and was blocked by voltage-dependent inactivation of Cav3 channels or by coexpressing a non calcium-conducting Cav3 channel pore mutant."
23626738
CACNA1A affects CALM3
1 |
CACNA1A binds CALM3. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects CALM2
1 |
CACNA1A binds CALM2. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects CACNA1C, DBP, and SBP
| 1
CACNA1A binds CACNA1C, DBP, and SBP. 1 / 1
| 1
sparser
"In the gene-based analysis, CACNA1A and CACNA1C were significantly associated with DBP change (P = 2.0×10 -5 ) and SBP change (P = 1.4×10 -4 ) after Bonferroni correction, respectively."
27418245
CACNA1A affects CACNA1B, and Voltage_gated_ion_channels
| 1
Voltage_gated_ion_channels binds CACNA1A and CACNA1B. 1 / 1
| 1
sparser
"It is well accepted that certain hereditary forms of migraine are associated with polymorphisms of voltage-gated calcium channels Cav2.1 and Cav2.2 ( xref )."
24151455
CACNA1A affects CACNA1B, CTX, and SCEI
| 1
CACNA1A binds CACNA1B, SCEI, and CTX. 1 / 1
| 1
sparser
"These results suggested that the characteristics of the specific binding of 125I-omega-CTX GVIA and 125I-omega-CTX MVIIC to Cav2.1 and Cav2.2 channels in the NBM were very similar to those to crude membranes from chick brain, although the IC50 values for CaM and free Ca2+ of CaM were about 33- and 5000-fold higher, respectively, than those for the specific binding of 125I-omega-CTX GVIA and 125I-omega-CTX MVIIC to crude membranes."
16076016
CACNA1A affects CACNA1B, CACNA1C, and Calcium_channels
| 1
Calcium_channels binds CACNA1A, CACNA1B, and CACNA1C. 1 / 1
| 1
sparser
"For instance, association of several voltage-dependent calcium channel genes such as CACNA1C and CACNA1B was reported in large-scale GWAS for BD. xref , xref A pathway analysis of GWAS data suggests enrichment of calcium channel-related pathways among the genes empirically associated with BD. xref Studies of peripheral blood cells have consistently demonstrated altered intracellular calcium signaling in BD. xref , xref Lithium, the first-line therapeutic drug for BD, modulates inositol-mediated pathways xref and thereby regulate calcium ion release from the endoplasmic reticulum. xref When we performed a GO enrichment analysis using DAVID xref , xref by integrating the data of de novo protein-altering mutations in our study, common single-nucleotide polymorphisms associated with BD in a large-scale GWAS xref and rare CNVs implicated in BD xref (total no. of unique input genes=229, see xref for details), ‘calcium signaling pathway (hsa04020)' was the only term significantly enriched after performing correction for multiple testing ( P corrected =6.4 × 10 −3 , Bonferroni correction; note that significant enrichment of ‘calcium signaling pathway (hsa04020)' after correction was not observed when we submitted candidate genes from each study)."
27217147
CACNA1A affects CA9
| 1
CACNA1A inhibits CA9. 1 / 1
| 1
sparser
"Together, our analysis revealed that SMA MNs display normal voltage dependent inactivation but faster recovery of Na + channels and suggest that SMN regulates AP pattern likely by modifying Na + -current activities."
26190808
CACNA1A affects C1QTNF1
1 |
CACNA1A binds C1QTNF1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects BTG3
1 |
BTG3 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects BLMH
| 1
BLMH binds CACNA1A. 1 / 1
| 1
sparser
"In contrast, when bound to Mhp1, L-BH and L-IMH become locked into an extended conformation (Supplementary Fig S3A–C, I–K), even if starting from an initial U-shaped conformation (Supplementary Fig S3E–H)."
24952894
CACNA1A affects BI
| 1
CACNA1A activates BI. 1 / 1
| 1
reach
"Bayesian inference (BI) and maximum likelihood (ML) analyses using amino acid sequences deduced from the 12 mitochondrial protein encoding genes (excluding ATP8) support the view that the three juliformian members are monophyletic (BI 100%; ML 100%), that Thyropygus (Spirostreptida) and Narceus (Spirobolida) are clustered together (BI 100%; ML 83%), and that Antrokoreana (Julida) is a sister of the two."
17464195
CACNA1A affects BDNF
| 1
BDNF binds CACNA1A. 1 / 1
| 1
sparser
"We conclude that the SCA6 pathogenic mechanism associates with the BDNF mRNA expression reduction and abnormal localization of BDNF protein."
22393909
CACNA1A affects BCL6
1 |
BCL6 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
16147992
CACNA1A affects B
| 1
CACNA1A binds B. 1 / 1
| 1
reach
"Therefore, the presence of F6 enhances the binding of b ', bI and bC to F, ~ OSCP, although F6 does not appear to form a strong direct interaction with the binary complex."
8206156
CACNA1A affects ATXN7
| 1
CACNA1A activates ATXN7. 1 / 1
| 1
reach
"XREF_BIBR SCA1, SCA2, Machado-Joseph or SCA3, SCA6, SCA7, SCA12, SCA17, and dentatorubral-pallidoluysian atrophy (DRPLA) are caused by (CAG) n repeat expansions in the ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, PPP2R2B, TBP, and ATN1 genes, respectively, and all lead to the expansion of a polyglutamine tract in the corresponding proteins."
24780882
CACNA1A affects ATPase
| 1
CACNA1A inhibits ATPase. 1 / 1
| 1
reach
"One class of antibody, B-I, inhibits ATPase activity; the other class, B-II, recognizes an epitope not exposed on the surface of intact F1."
2440872
CACNA1A affects ATP2A1
| 1
CACNA1A activates ATP2A1. 1 / 1
| 1
sparser
"In mammalian cardiac muscle voltage-dependent activation of slow channels, e.g., the slow inward current channel, may be possible only when the channels are phosphorylated."
6265236
CACNA1A affects AP2M1
1 |
CACNA1A binds AP2M1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects AOX4
| 1
CACNA1A activates AOX4. 1 / 1
| 1
sparser
"The M-channel opener retigabine negatively shifted the voltage-dependent activation of IM, leading to membrane hyperpolarization, increased rheobase and suppression of both evoked and spontaneous action potential (AP) firing in nodose neurons in the M-channel inhibitor XE991-sensitive manner."
30721152
CACNA1A affects AOPEP
| 1
AOPEP binds CACNA1A. 1 / 1
| 1
sparser
"In particular, xref shows that binding of Na + to an apo-state of Mhp1 in the absence of substrate is energetically unfavorable."
24204233
CACNA1A affects ALDOA
1 |
CACNA1A binds ALDOA. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects AGRN
1 |
CACNA1A binds AGRN. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects ADRB
| 1
ADRB binds CACNA1A. 1 / 1
| 1
sparser
"In our previous studies, we demonstrated that ISO-βAR stimulation is associated with the modulation of Ca 2+ -activated K + , inward rectifier K + , and voltage-dependent K + channels in coronary arterial smooth muscle cells, which suggested functional modification of arterial smooth muscle cells during βAR stimulation xref , xref , xref ."
22916309
CACNA1A affects ADAM8
| 1
CACNA1A binds ADAM8. 1 / 1
| 1
sparser
"None of these antibodies inhibited the binding of human MAb MS2B6 to partially purified EA2B6."
1382650
CACNA1A affects ACTN1
1 |
CACNA1A binds ACTN1. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects ABCA2
1 |
CACNA1A binds ABCA2. 1 / 1
1 |
biogrid
No evidence text available
21078624
CACNA1A affects ABC transporter substrate-binding protein
| 1
CACNA1A activates ABC transporter substrate-binding protein. 1 / 1
| 1
reach
"Infantis, BINF_17219F (5 '-AGGTTACTTCGACGCCTTCT-3 ') and BINF_17219R (5 '-AGGTATTCGGTGACCAGCTT-3 '), targeting a carbohydrate ABC transporter substrate binding protein; and for E. coli, 0.1 muM of the following primers : Eco1457F (5 '-CATTGACGTTACCCGCAGAAGAAG) and Eco1652R (5 '-CTCTACGAGACTCAAGCTTGC-3 ')."
28976925
CACNA1A affects 5-bromo-2'-deoxyuridine
| 1
CACNA1A activates 5-bromo-2'-deoxyuridine. 1 / 1
| 1
reach
"MK performed B/I activation of T cells, flow cytometry, MLR, and BrdU proliferation assays; MG performed flow cytometry; LG performed B/I activation of T cells; KG participated in study design; HDB participated in study design and manuscript preparation; FMM participated in study design and data analysis; MHM designed the experiments, analyzed data, and prepared the manuscript."
19849846
CACNA1A affects 4T1 tDLN
| 1
CACNA1A activates 4T1 tDLN. 1 / 1
| 1
reach
"To test the hypothesis that T CM cells (which should be CD62L +) generated after B/I activation are responsible for the efficacy of these cells at inducing tumor regression, we separated B/I activated and expanded 4T1 tDLN into CD62L + and CD62L - fractions, using magnetic beads."
21050466
CACNA1A affects 4T1 DLN
| 1
CACNA1A activates 4T1 DLN. 1 / 1
| 1
reach
"We have previously shown and published that adoptive transfer of B/I activated 4T1 DLN was ineffective at inducing tumor regression [XREF_BIBR, XREF_BIBR]."
21050466
CACNA1A affects 3H
| 1
CACNA1A binds 3H. 1 / 1
| 1
sparser
"3H-D600 (3H-Gallopamil), a Ca(2+)-channel antagonist, binds to the voltage-dependent Ca2+ channels (VDCC) in a specific, saturable, and reversible manner."
1741494
CACNA1A affects (R)-lipoic acid
| 1
(R)-lipoic acid binds CACNA1A. 1 / 1
| 1
sparser
"Recently there has been considerable progress in understanding the mechanism of voltage-dependent binding of LA drugs."
22053156
C1QTNF1 affects CACNA1A
1 |
CACNA1A binds C1QTNF1. 1 / 1
1 |
biogrid
No evidence text available
21078624
Blood Pressure affects CACNA1A, and SNP
| 1
CACNA1A binds Blood Pressure and SNP. 1 / 1
| 1
sparser
"CACNA1A SNP rs8182538 was significantly associated with longitudinal diastolic BP (DBP) change after Bonferroni correction (P interaction = 9.90×10 -5 ), with mean DBP increases of 0.85, 1.03, and 1.19mm Hg per year for participants with genotypes C/C, C/T, and T/T, respectively."
27418245
BTG3 affects CACNA1A
1 |
BTG3 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
21078624
BRM affects CACNA1A
| 1
BRM activates CACNA1A. 1 / 1
| 1
reach
"We then compared the GABA release induced by the light activation of ChR-2 in cortical slices from SST Cre; Cacna1a c/c mutants carrying a targeted Cacna1a LOF mutation in all SST populations, versus SST Cre littermate controls."
23595603
BLMH affects CACNA1A
| 1
BLMH binds CACNA1A. 1 / 1
| 1
sparser
"In contrast, when bound to Mhp1, L-BH and L-IMH become locked into an extended conformation (Supplementary Fig S3A–C, I–K), even if starting from an initial U-shaped conformation (Supplementary Fig S3E–H)."
24952894
BI affects CACNA1A
| 1
BI activates CACNA1A. 1 / 1
| 1
reach
"BI systems provide very effectively (level 5 on the Likert scale) promote the accumulation of business intelligence (X 12)."
27376005
BDNF affects CACNA1A
| 1
BDNF binds CACNA1A. 1 / 1
| 1
sparser
"We conclude that the SCA6 pathogenic mechanism associates with the BDNF mRNA expression reduction and abnormal localization of BDNF protein."
22393909
BCL6 affects CACNA1A
1 |
BCL6 binds CACNA1A. 1 / 1
1 |
biogrid
No evidence text available
16147992
BAX affects CACNA1A
| 1
CACNA1A binds BAX. 1 / 1
| 1
sparser
"Moreover, the release of cytochrome c from the mitochondria is dependent on cyclosporin A-sensitive mitochondrial permeability transition pore opening, but not formation of the Bax-voltage dependent anion channel complex or Bax oligomeric pores."
26164288
BAK1 affects BID, and CACNA1A
| 1
BID binds CACNA1A and BAK1. 1 / 1
| 1
sparser
"We further established for the first time that the C-terminal domain of Mcl-1 became proapoptotic as a result of caspase-3 cleavage, and its physical interaction and cooperation with tBid, Bak, and voltage-dependent anion-selective channel 1 promoted mitochondrial apoptosis."
15637055
B affects CACNA1A
| 1
CACNA1A binds B. 1 / 1
| 1
reach
"Therefore, the presence of F6 enhances the binding of b ', bI and bC to F, ~ OSCP, although F6 does not appear to form a strong direct interaction with the binary complex."
8206156
AgNPs affects CACNA1A
| 1
AgNPs decreases the amount of CACNA1A. 1 / 1
| 1
reach
"In vitro experiments reveal that AgNPs treatment significantly reduces the protein and mRNA levels of CACNA1A in primary cultured cerebellum granule cells (CGCs)."
26068065
ATXN3 affects CACNA1A, Calcium_channels, and Voltage_gated_ion_channels
| 1
Calcium_channels binds Voltage_gated_ion_channels, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"Autosomal dominant mutations in the CACNA1A gene, which encodes the voltage-gated P/Q-type calcium channel alpha1 subunit, has also been associated with cerebellar ataxia, vertigo, epilepsy, and schizophrenia (see below) in addition to FHM (Lhatoo et al., xref )."
24312013
ATXN1 affects ATXN2, ATXN3, and CACNA1A
| 1
ATXN1 binds ATXN2, CACNA1A, and ATXN3. 1 / 1
| 1
sparser
"We also analyzed the possibility of genetic interactions between ATXN1 and ATXN2, ATXN2 and ATXN3, and ATXN2 and CACNA1A. Intermediate-length polyQ expansions (>24 Qs) of ATXN2 were found in 7 ADPD patients and no controls (7/299 = 2.34% and 0/329 = 0%, respectively; p = 0.0053 < 0.05/8 after Bonferroni correction)."
24534762
ATXN1 affects ATXN2, ATXN3, ATXN7, CACNA1A, PPP2R2B, and TBP
| 1
ATXN1 binds ATXN2, ATXN7, TBP, CACNA1A, ATXN3, and PPP2R2B. 1 / 1
| 1
sparser
"By contrast, only 7% (41 out of 584) of the interacting proteins recorded in for the ATXN1, ATXN2, ATXN3, ATXN7, CACNA1A, TBP and PPP2R2B interact with each other (data not shown)."
22967711
ATPase activity affects CACNA1A
| 1
ATPase activity binds CACNA1A. 1 / 1
| 1
sparser
"It; should also 520 S. Persad et aI. ~Pable 7 Modification ofoubain-sensitive (Na+-K+)-ATPase and calcium channel binding activities by deoxycholate treatment Oubain- sensitive [~HI PN200-1] 0 binding (Na +-K ~ )-ATPase ...... (#too/Pjmg/h) Kd (riM) Bma.~ (fmoI/mg) Control 7.8 0.5 0.46 0.05 170 18 DOC treatment 7.6 0.6 0.44 0.04 221 22" Crude membranes were incubated without or with deoxycho/ate (DOC/prntein ratio 0.5) at 30: for 10 rain."
7760371
ATP5MF affects CACNA1A, and ENO
| 1
ENO binds CACNA1A and ATP5MF. 1 / 1
| 1
sparser
"In Anopheles gambiae , the vacuolar ATP synthase subunit f and a voltage-dependent anion-selective channel protein interact with Plasmodium enolase mimetic peptide SM-1 [ xref ], a porin whose function in brain cells is still unclear."
27724938
ATP5F1D affects CACNA1A, and CAPZA2
| 1
CACNA1A binds CAPZA2 and ATP5F1D. 1 / 1
| 1
sparser
"Pregabalin binds to the alpha 2-delta subunit of voltage-dependent calcium channels in the central nervous system reducing presynaptic end neuronal calcium currents."
25766346
APLN affects CACNA1A
| 1
APLN inhibits CACNA1A. 1 / 1
| 1
sparser
"The effects of apelin in cerebral arteries are unknown; however, apelin inhibits voltage-dependent increases in large-conductance, calcium-activated K channel (BK Ca ) currents in cerebral artery smooth muscle cells."
29620606
AP2M1 affects CACNA1A
1 |
CACNA1A binds AP2M1. 1 / 1
1 |
biogrid
No evidence text available
21078624
AOPEP affects CACNA1A
| 1
AOPEP binds CACNA1A. 1 / 1
| 1
sparser
"In particular, xref shows that binding of Na + to an apo-state of Mhp1 in the absence of substrate is energetically unfavorable."
24204233
ANXA5 affects ANXA6, ANXA7, CACNA1A, and TA
| 1
CACNA1A binds ANXA5, ANXA6, ANXA7, and TA. 1 / 1
| 1
sparser
"TA Voltage dependent binding of annexin V, annexin VI and annexin VII-core to acidic phospholipid membranes Andreas Hofmann a,*, Jiirg Benz a, Susanne Liemann b, Robert Huber ~ Max-Planck-lnst#ut fiir Biochemie, Abt."
9408179
ALDOA affects CACNA1A
1 |
CACNA1A binds ALDOA. 1 / 1
1 |
biogrid
No evidence text available
21078624
AKBA affects CACNA1A
| 1
AKBA increases the amount of CACNA1A. 1 / 1
| 1
reach
"We found that AKBA suppressed the formation of autolysosome, and decreased the expression levels of Beclin-1, LC3A and B-I, and LC3A and B-II proteins."
32158225
AGRN affects CACNA1A
1 |
CACNA1A binds AGRN. 1 / 1
1 |
biogrid
No evidence text available
21078624
AGO4 affects CACNA1A
| 1
AGO4 bound to miR-3191-5p inhibits CACNA1A. 1 / 1
| 1
reach
"These results suggest that miR-3191-5p bound to Ago4 directly interacts with the CACNA1A IRES and selectively inhibits the CACNA1A IRES driven alpha1ACT translation."
27412786
ADRB affects CACNA1A
| 1
ADRB binds CACNA1A. 1 / 1
| 1
sparser
"In our previous studies, we demonstrated that ISO-βAR stimulation is associated with the modulation of Ca 2+ -activated K + , inward rectifier K + , and voltage-dependent K + channels in coronary arterial smooth muscle cells, which suggested functional modification of arterial smooth muscle cells during βAR stimulation xref , xref , xref ."
22916309
ADAM8 affects CACNA1A
| 1
CACNA1A binds ADAM8. 1 / 1
| 1
sparser
"None of these antibodies inhibited the binding of human MAb MS2B6 to partially purified EA2B6."
1382650
ACTN1 affects CACNA1A
1 |
CACNA1A binds ACTN1. 1 / 1
1 |
biogrid
No evidence text available
21078624
ACTA1 affects CACNA1A
| 1
ACTA1 inhibits CACNA1A. 1 / 1
| 1
reach
"BIOCHIMICA ET BIOPHYSICA ACTA 791 BBA 66539 INACTIVATION OF SERINE TRANSHYDROXYMETHYLASE AND THREONINE ALDOLASE ACTIVITIES bI."
5017703
ACKR2 affects BAG6, CACNA1A, El-G3 and BI-D6, and TBCEL
| 1
CACNA1A binds BAG6, ACKR2, TBCEL, and El-G3 and BI-D6. 1 / 1
| 1
sparser
"El-G3 and BI-D6 antibodies did not form any visible im- mune complex with the respective antigen (human yy and bovine yy enolase, respectively)."
6375733
ABCC8 affects CACNA1A, and RFX3
| 1
CACNA1A binds ABCC8 and RFX3. 1 / 1
| 1
sparser
"Binding of Rfx3 to Abcc8 or voltage-dependent Ca 2+ channel genes has not been reported, and although Rfx6 and Rfx3 might coregulate other targets genes, the extent of the functional redundancy of both transcription factors in β cell function and insulin secretion cannot be evaluated, as the phenotype of mice with a deletion of  Rfx3 in adult β cells has not been described."
25497096
ABCA2 affects CACNA1A
1 |
CACNA1A binds ABCA2. 1 / 1
1 |
biogrid
No evidence text available
21078624
AAV9 affects CACNA1A
| 1
AAV9 activates CACNA1A. 1 / 1
| 1
reach
"Mice expressing AAV9 mediated CACNA1A IRES driven alpha1ACT SCA6 exhibited early-onset ataxia, motor deficits, and Purkinje cell degeneration."
27412786
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid affects CACNA1A
| 1
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid inhibits CACNA1A. 1 / 1
| 1
sparser
"These currents had characteristics typical of I Cl, swell ( xref ): voltage-independent block by DCPIB, voltage-dependent inhibition by DIDS (4,4′ diisothio-cyanatostilbene-2,2′-disulfonic acid), largely permeable to Cl − (see Methods), and mild outwardly rectifying."
24725410
3H affects CACNA1A
| 1
CACNA1A binds 3H. 1 / 1
| 1
sparser
"3H-D600 (3H-Gallopamil), a Ca(2+)-channel antagonist, binds to the voltage-dependent Ca2+ channels (VDCC) in a specific, saturable, and reversible manner."
1741494
3',5'-cyclic AMP affects CACNA1A
| 1
3',5'-cyclic AMP activates CACNA1A. 1 / 1
| 1
sparser
"Further studies including investigations into the complex modulation of voltage-dependent channel activation by cyclic AMP will be necessary to verify this putative mechanism."
10940384
(S)-carnitine affects CACNA1A
| 1
(S)-carnitine decreases the amount of CACNA1A. 1 / 1
| 1
reach
"Only LC3A and B-I level was decreased by maternal L-Carnitine treatment (P < 0.05, Figure XREF_FIG)."
28243190
(R)-lipoic acid affects CACNA1A
| 1
(R)-lipoic acid binds CACNA1A. 1 / 1
| 1
sparser
"Recently there has been considerable progress in understanding the mechanism of voltage-dependent binding of LA drugs."
22053156
(+)-abscisic acid affects CACNA1A
| 1
(+)-abscisic acid activates CACNA1A. 1 / 1
| 1
sparser
"During strong responses (DeltaG > 5 nS), however, ABA activated voltage-dependent (rapid (R)-type) in addition to S-type anion channels."
14756768
CACNA1A affects calcium(2+), and calcium(2+)
|
CACNA1A catalyzes the conversion of calcium(2+) into calcium(2+). 7 / 7
7 |
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available